34 results on '"Miranda, Alexandra"'
Search Results
2. The Role of Operative Vaginal Delivery in Postpartum Sexual Dysfunction: MOODS - A Prospective Study
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de Sousa, Natacha Quintal, Borges, Ana Catarina, Sarabando, Rita, Bivar, Leonor, Viana, Johanna, Cerqueira, Margarida, Miranda, Alexandra, Reis, Isabel, and Nogueira-Silva, Cristina
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- 2021
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3. “It felt like my son had died”: Zero tolerance and the trauma of family separation
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Gil-García, Óscar F., Bové, Francesca, Velazquez, Luz, Vener, Sarah, and Miranda, Alexandra
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- 2021
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4. Association of first trimester biochemical screening markers with adverse outcomes in pregnancies resulting from assisted reproduction techniques versus spontaneous pregnancies
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Catarina Borges, Ana, primary, Sousa, Helena, additional, Almendra, Rita, additional, Rodrigues, Raquel, additional, Pereira, Elsa, additional, Trocado, Vera, additional, and Miranda, Alexandra, additional
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- 2024
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5. Characterisation of LVI-1 (WDR76) as a candidate tumour suppressor gene
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Miranda, Alexandra de Sousa Montenegro
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616.994 ,QR Microbiology ,RC0254 Neoplasms. Tumors. Oncology (including Cancer) - Abstract
The central aim of this study was to characterise the expression of the candidate tumour suppressor gene, LV/-J (lentivirus integration-I) and its products. The LVI-J gene (WDR76) was discovered as a target for disruption by proviral insertional mutagenesis in a case of pre-B cell lymphoma in a FIV infected cat {Beatty, 1998 5 lid; Beatty, 2002 7 lid}. As LV/-J is highly conserved, my work focused on the human and murine orthologues to take advantage of the superior resources available for these species. My work showed potentially important differences in expression of the human and mouse genes with respect to promoter use and length of 3' untranslated sequences. The murine gene is transcribed mainly from the distal PI promoter, which appears to be a bi-directional element shared with the adjacent MJapJ gene, while the human gene transcripts are derived exclusively from the proximal P2 promoter. Direct analysis by RT-PCR showed that the murine gene could also be expressed from the P2 promoter. These findings have significant implications for Lvi-l protein expression as the P2 transcripts are predicted to express larger proteins with a distinct N-terminal sequence. To characterise the LV/-J gene products, rabbit polyclonal antisera were raised to GST fusion proteins expressed in bacteria. Use of the murine anti-ml.vi-I antiserum in Western blotting identified a protein of the expected size (58 kDa) based on translation of the major mRNA species from the PI promoter. Immunofluorescence and confocal microscopy suggested that this protein is localised mainly in the cytoplasm. Although the function of LVI-I is unknown, its closest relative in the human genome is DDB2, a protein involved in repair of UV-induced DNA damage. Regulation of LVI-I expression was examined after UV irradiation, providing preliminary evidence of responses at transcriptional and post-transcriptional levels. Further leads were followed by analogy with the yeast orthologue of LVI-I, YDLI56W, but no evidence of a complex between LVI-I and MSH6 was found. In conclusion, while function of the LVI-I gene remains to be establishes, it provides the basis for future characterisation of this highly conserved and potentially important eukaryotic gene.
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- 2006
6. Correction to: “It felt like my son had died”: Zero tolerance and the trauma of family separation
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Gil-García, Óscar F., Bové, Francesca, Velazquez, Luz, Vener, Sarah, and Miranda, Alexandra
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- 2021
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7. Relación entre las características específicas del acompañamiento familiar con el rendimiento académico, de niñas y niños del grado transición en el Centro Educativo Mata de Caña del municipio de Lorica, Córdoba
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Maussa Miranda, Alexandra Patricia, Monterrosa Morales, Angélica María, and Pacheco Lora, Luis Carlos
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Family-school relationship ,Acompañamiento familiar ,Hábitos de estudio ,Study habits ,Family time ,Rendimiento académico ,Family accompaniment ,Relación familia-escuela ,Academic performance ,Learning processes ,Tiempo familiar ,Procesos de aprendizaje - Abstract
This document is based on the analysis of the relationship between academic performance and the specific characteristics of the family accompaniment that children of the transition grade of the Mata de Caña Educational Center of the Municipality of Lorica, Córdoba, receive in their learning process; As it is well known, family accompaniment is fundamental in the formation of the student, it is a factor in which the greatest responsibility of education lies, these must work together in a transversal way, with the school and the parents. They contribute in the formative mission, given that both, family-school, have as an objective the development of the human being's abilities. In order to identify the way in which parents participate in the processes, interviews were conducted where each of these aspects were made known; as well as the factors associated with the academic performance of the students who have accompaniment; likewise, the relationship between academic performance and the specific procedures of family accompaniment is described. With all the above mentioned, we intend to centralize the family accompaniment and give it the importance it deserves as a basis for the integral development of the children, more specifically those of the Mata de Caña Educational Institution. In the same way, if no methods of family accompaniment are observed, some workshops, activities, parents' school or any activity that helps families to commit themselves to their children's education will be recommended. Not only because of the above mentioned, since it is important to mention the lack of interest on the part of parents or guardians, making all of these related to the performance of children in the classroom. Resumen................................................................................................................................................................................................5 Introducción ........................................................................................................................................................................................1 1. Planteamiento del problema...............................................................................................................................................3 1.1. Descripción del problema.....................................................................................................................................................3 1.2. Formulación del problema...................................................................................................................................................5 1.2.1. Formulación de preguntas auxiliadoras. ............................................................................................................5 2. Justificación.................................................................................................................................................................................6 3. Objetivos......................................................................................................................................................................................8 3.1. General .........................................................................................................................................................................................8 3.2. Específicos ..................................................................................................................................................................................8 4. Marco referencial.....................................................................................................................................................................9 4.1. Estado del Arte..........................................................................................................................................................................9 4.1.1. A nivel internacional. ....................................................................................................................................................9 4.1.2. A nivel nacional............................................................................................................................................................13 4.1.3. A nivel local. ..................................................................................................................................................................17 4.2. Marco Teórico.........................................................................................................................................................................20 4.2.1. Frecuencia de las intervenciones (padres/acudientes) en el proceso educativode sus hijos. 23 4.2.2. Rendimiento académico de los estudiantes que tienen acompañamiento......................................25 4.2.3. Relación entre el rendimiento académico y las características específicas del acompañamiento familiar................................................................................................................................................26 4.3. Marco Conceptual..................................................................................................................................................................30 4.3.1. Rendimiento académico..........................................................................................................................................30 4.3.2. Acompañamiento familiar.......................................................................................................................................31 4.3.3. Educación Inicial. ........................................................................................................................................................32 5. Metodología. ...........................................................................................................................................................................34 5.1. Diseño o estructura metodológico ................................................................................................................................34 5.2. Población y Muestra. ..........................................................................................................................................................35 5.3. Cuadro de categorización ..................................................................................................................................................37 5.4. Marco contextual...................................................................................................................................................................44 5.5. Técnicas e instrumentos de recolección de información...................................................................................45 5.5.1. Entrevistas. ...................................................................................................................................................................45 5.5.1.1. Entrevista Semiestructurada.......................................................................................................................45 5.5.2. Observación..................................................................................................................................................................46 5.6. Técnicas de análisis de información............................................................................................................................47 5.7. Procedimiento investigativo.............................................................................................................................................47 5.7.1. FASE 1: Preparación y organización....................................................................................................................47 5.7.2. FASE 2: Aplicación de instrumentos. .................................................................................................................48 5.7.3. FASE 3: Interpretación de los datos cualitativos.........................................................................................48 6. Análisis y discusión de los resultados. ........................................................................................................................49 6.1. Análisis de la categoría participación y comunicación; Familia y Procesoseducativos. ....................49 6.2. Análisis de la categoría factores asociados; Rendimiento académico yAcompañamiento familiar .......................................................................................................................................................................................................65 6.3. Análisis de la categoría relación del rendimiento académico; Característicasespecíficas familiares .......................................................................................................................................................................................................81 6.4. Análisis de interpretación Subcategorías y pregunta docente.......................................................................89 6.4.1. Participación y comunicación con las Familias y Procesos educativos............................................89 6.5. Factores asociados; Rendimiento académico yAcompañamiento familiar .............................................90 6.5.1. Relación con las familias y Características específicas del acompañamientoFamiliar...............91 7. Conclusiones...........................................................................................................................................................................93 8. Recomendaciones ................................................................................................................................................................94 9. Referencias..............................................................................................................................................................................95 10. Anexos. ................................................................................................................................................................................... 100 10.1. Entrevistas ................................................................................................................................................................. 100 10.2. Entrevista docente y acuerdo de confidencialidad .................................................................................. 191 10.3. Acuerdos de confidencialidad ............................................................................................................................ 201 10.4. Agrupaciones por preguntas entrevistas..................................................................................................... 215 El presente documento se basa en el análisis de la relación del rendimiento académico con las características específicas del acompañamiento familiar que reciben en su proceso de aprendizaje los niños y niñas del grado transición del Centro Educativo Mata de Caña, del Municipio de Lorica, Córdoba; como es bien sabido el acompañamiento familiar es fundamental en la formación del estudiante, es un factor en el cual recae la mayor responsabilidad de la educación, éstos deben trabajar conjuntamente de manera transversal con la escuela y los padres de familia. Contribuyen en la misión formadora, dado que ambos, familia-escuela, tienen como finalidad el desarrollo de las habilidades del ser humano. Para que se logre identificar la manera en que los padres de familia participan en los procesos se realizaron entrevistas donde se dio a conocer cada uno de estos aspectos, como también se describe los factores asociados del rendimiento académico de los estudiantes que tienen acompañamiento; del mismo modo, se busca caracterizar la relación entre el rendimiento académico y los procedimientos específicos del acompañamiento familiar. Con todo lo nombrado se pretende centralizar el acompañamiento familiar y darle la importancia que merece como base en el desarrollo integral de los niños y niñas más en específico a los de la Institución Educativa Mata de Caña, al igual informar si no se observan métodos de acompañamiento familiar se recomendarán algunos talleres, actividades, escuela de padres o cualquier actividad que ayuda a las familias para que se comprometan con la educación de sus hijos. Se busca realizar una investigación transversal donde la información no esté sobrecargada. No sólo por lo mencionado anteriormente, ya que es importante mencionar el poco interés por parte de los padres o tutores, haciendo que todo estos se relacionen con el rendimiento de los niños y niñas en el aula de clase. Pregrado Licenciado(a) en Educación Infantil Trabajos de Investigación y/o Extensión
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- 2023
8. Pelvic floor dysfunction after vaginal delivery: MOODS—a prospective study
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Borges, Ana Catarina, primary, Sousa, Natacha, additional, Sarabando, Rita, additional, Vieira, Catarina, additional, Ribeiro, Bárbara, additional, Barbosa, Paulina, additional, Miranda, Alexandra, additional, Reis, Isabel, additional, and Nogueira-Silva, Cristina, additional
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- 2021
- Full Text
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9. Pregnancy and COVID-19: a systematic review of maternal, obstetric and neonatal outcomes.
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Trocado, Vera, Silvestre-Machado, Joana, Azevedo, Lídia, Miranda, Alexandra, and Nogueira-Silva, Cristina
- Abstract
There is limited information related to COVID-19 in pregnancy. Evaluate the impact of COVID-19 during pregnancy. Search strategy: Searches were systematically carried out in PubMed, Scopus database and WHO database. Selection criteria: Studies with information related to the effects of COVID-19 in pregnancy, concerning maternal, obstetric, and neonatal outcomes were included. Data collection and analysis: Data were extracted for systematic review following PRISMA guidelines. CARE and STROBE were used to evaluate the quality of data. Main Results: A total of 8 studies involving 95 pregnant women and 51 neonates were included. Overall, the quality was considered good in four studies, moderate in three and poor in one. Among pregnant women, 26% had a history of epidemiological exposure to SARS-CoV-2. The most common symptoms presented were fever (55%), cough (38%) and fatigue (11%). In 50 deliveries, 94% were cesarean sections and 35% were preterm births. Of the 51 neonates, 20% had low birth weight and 1 tested positive for Sars-CoV-2. There was 1 neonatal death, not related to the viral infection, and no cases of severe neonatal asphyxia. The information compiled in this systematic review may help healthcare providers administer the best possible care. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Pregnancy and COVID-19: a systematic review of maternal, obstetric and neonatal outcomes
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Trocado, Vera, primary, Silvestre-Machado, Joana, additional, Azevedo, Lídia, additional, Miranda, Alexandra, additional, and Nogueira-Silva, Cristina, additional
- Published
- 2020
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11. Avaliação da experiência das pacientes na histeroscopia de consultório versus ambulatório
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Miranda, Alexandra, Ribeiro, Bárbara, Ferreira, Sandra, Afonso, Hermínia, Rocha, Afonso, Reis, Isabel, and Nogueira-Silva, Cristina
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Office ,Ambulatory ,Satisfaction ,Pain ,Hysteroscopy - Abstract
Overview and Aims: Technology has allowed hysteroscopy to be increasingly performed in the office (HO). Yet, fear of patient pain associated with HO still prevents clinicians from choosing it instead of traditional hysteroscopy (HA). We aimed to compare pain perception and satisfaction in patients submitted to HO versus HA and to determine socio-demographic and clinical factors that influence patient experience. Methods: We performed a prospective, observational, descriptive and analytical study, comparing women submitted to HA (n=119) and HO (n=113), between September and December 2016 and January to July 2017, respectively. Three self-report questionnaires were answered by the patients before, immediately and one month after the hysteroscopy, and another questionnaire was answered by the clinician in charge of the technique. Results: Both HA and HO groups showed similar socio-demographic characteristics. Differences were found between felt and expected pain, both in HA (p
- Published
- 2019
12. Risk factors for anxiety and pain perception during levonorgestrel intrauterine system insertion
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Miranda, Alexandra, Almendra, Rita, Feliciano, Esmeralda, Ricardo, Cardoso, Nápoles, Saritta, and Cristina Nogueira-Silva
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Contraception ,LNG-IUS ,Mirena® ,Pain ,Anxiety ,Jaydess® - Abstract
Overview and Aims: Levonorgestrel Intrauterine System (LNG-IUS) is an efficacious and cost-effective long acting reversible contraceptive, with high satisfaction rates among users. Yet, evidence shows that anxiety and fear of pain associated with LNG-IUS insertion prevent women from choosing them as their contraceptive method. We aimed to determine risk factors associated with anxiety and pain perception during LNG-IUS insertion. Methods and Population: We performed a prospective, observational, descriptive and analytical study to a sample of patients of the family planning consultation submitted to insertion of LNG-IUS between may and november 2017. Pre and post insertion questionnaires were given, one directed to the patients and other to the clinicians. Results: From a total of 161 women in analysis, 125 inserted Mirena® and 36 inserted Jaydess®. The patients submitted to the insertion of Jaydess® were significantly younger (median=34) than those who chose Mirena® (median=41) and presented higher frequency of nulliparity and absence of vaginal delivery. Higher levels of anticipated pain correlated with high levels of anxiety (p
- Published
- 2018
13. The Impact of an Educational Support Program on Formal Caregivers of Elderly People with Dementia in the Institutional Context
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Miranda, Alexandra, primary, Dias, Maria Isabel, additional, and Lopes Gunes, Alexandra Cristina, additional
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- 2019
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14. Association between biochemical screening for fetal aneuploidy in the first trimester and adverse obstetric outcomes
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Miranda,Alexandra, Azevedo,Cátia, Cadilhe,Alexandra, and Reis,Isabel
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Pregnancy-associated placental protein A (PAPP-A) ,Preterm delivery ,Free b-human chorionic gonadotropin (free b-hCG) ,First trimester screening ,Pre-eclampsia - Abstract
Overview: The first trimester screening for fetal aneuploidy includes a combined evaluation of maternal age, obstetric history, ultrasound and biochemical markers. Variations in maternal serum levels of biochemical markers (free b-hCG and PAPP-A) have been associated with adverse obstetric outcomes, even in the absence of aneuploidy. This study aimed to evaluate the association of PAPP-A and free b-hCG with the occurrence of adverse obstetric outcomes, in an obstetric population with negative first trimester screening for chromosomal abnormalities. Study design: Observational, descriptive, analytic and retrospective study that included 1128 pregnancies with a negative first trimester screening, in 2013. Delivery occurred in our Hospital. Methods: The levels of both biochemical markers (free b-hCG and PAPP-A) were compared between groups with a given adverse obstetric outcome and women without any adverse event. Binary logistic regression and multiple linear regression analysis were performed to determine if free b-hCG and PAPP-A were important predictors for adverse outcomes. Results: Maternal serum levels of PAPP-A were significantly lower in women who developed pre-eclampsia compared to women without any adverse obstetric outcome (0.98±0.2 vs. 1.18±0.63 MoM; p=0.027). Maternal serum free b-hCG was significantly lower in pregnant women who had birth before 37 weeks of gestation, compared to pregnant women with a term birth (median; interquartile range: 0.78; 0.39 vs.0.94; 0.75 MoM; p=0.037). Linear regression analysis showed that PAPP-A is an independent predictor of fetal birth weight and that free b- hCG is a predictor of fetal gestational age at birth. Conclusion: Serum PAPP-A and free â-hCG in the first trimester are significantly reduced in pregnancies, with a negative first trimester combined screening for fetal aneuploidy, who developed pre-eclampsia and had a preterm delivery, respectively. In these populations, for a better risk assessment, we suggest to perform pre-eclampsia and preterm labour screening.
- Published
- 2017
15. Tart Cherry Reduces Inflammation in Adipose Tissue of Zucker Fatty Rats and Cultured 3T3-L1 Adipocytes
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Jayarathne, Shasika, primary, Stull, April, additional, Miranda, Alexandra, additional, Scoggin, Shane, additional, Claycombe-Larson, Kate, additional, Kim, Jung, additional, and Moustaid-Moussa, Naima, additional
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- 2018
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16. Maternal hormonal milieu influence on fetal brain development
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Miranda, Alexandra, primary and Sousa, Nuno, additional
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- 2018
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17. Trabajo de Investigaci?n previo a la obtenci?n del t?tulo de Magister en Ciencias de la Educaci?n Menci?n Educaci?n Parvularia
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L?pez Miranda, Alexandra Elizabeth and Ord??ez, Fernanda
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conducta ,Tics ,personalidad ,inform?tica ,telecomunicaciones ,control - Abstract
En el presente trabajo de investigaci?n sobre Las tic?s y los patrones de conducta de los ni?os y ni?as del centro de educaci?n inicial ?camilo torres ortega? del cant?n san Pedro de Pelileo, provincia de Tungurahua en el a?o 2012 ? 2013, se determin? el objetivo, el uso inadecuado de las tics incide en la adquisici?n de patrones de conducta incorrectos de los ni?os y ni?as de Educaci?n Inicial ?Camilo Torres Ortega? del cant?n San Pedro de Pelileo provincia de Tungurahua en el a?o 2012? Adem?s se plante? el problema para evaluar esta incidencia de las tecnolog?as inform?ticas en los patrones conductuales de los ni?os y ni?as y as? se estableci? interrogantes que llevaron a establecer las variables de investigaci?n. Se realiz? investigaci?n bibliogr?fica de estudios previos para conocer el argumento que sustente al tema en donde se hall? investigaciones que proporcionaron valiosa informaci?n a la investigaci?n. No obstante se estableci? la metodolog?a empleada en el proceso de investigaci?n, trabajando con herramientas como las encuestas dirigidas a padres de familia y a docentes y fichas de observaci?n de los ni?os, y ni?as; el resultado de esta investigaci?n revela conductas agresivas en los ni?os y ni?as y dificultades en los proceso de integraci?n y sociabilidad, y menor atenci?n a los procesos de aprendizaje lo que perjudica el rendimiento escolar, ocasionado por la escasa atenci?n de los padres de familia y la falta de una gu?a tanto por parte de los docentes como de los padres, sin embargo existe el inter?s de los padres para que sus hijos aprendan a manejar las nuevas tecnolog?as de forma adecuada y que esto les sirva como ventaja en el ?mbito educativo y mejore su rendimiento acad?mico, ya que los estudiantes pasan horas y horas en la computadora, pero ser?a muy valioso transformar esas horas de ocio en horas productivas y de beneficio en el aprendizaje de nuevos conocimientos. Consecuentemente la propuesta es una gu?a sobre el manejo de las Tic?s como recurso did?ctico que beneficia el proceso de ense?anza aprendizaje mejorando los patrones de conducta.
- Published
- 2016
18. Gestió d'horaris de recepció de mercaderia als magatzems reguladors d'una empresa del gran consum
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Torres Miranda, Alexandra and Abeijón Monjas, David
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Magatzems -- Direcció i administració ,Business logistics -- Management ,Warehouses -- Management ,Distribució de mercaderies -- Planificació ,Economia i organització d'empreses [Àrees temàtiques de la UPC] ,Physical distribution of goods -- Planning ,Logística (Indústria) -- Direcció i administració - Published
- 2016
19. Uterine Rupture in Early Pregnancy
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Miranda, Alexandra, primary, Castro, Luís, additional, Rocha, Maria José, additional, Cardoso, Luísa, additional, and Reis, Isabel, additional
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- 2017
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20. Non-invasive fetal RhD genotyping – economic impact on antenatal Rh isoimunization prophylaxis
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Miranda, Alexandra Sofia Lopes, Ferreira, Marta, Castro, Luís, Cadilhe, Alexandra, Pena, Domingos Jardim da, and Universidade do Minho
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Medicina Clínica [Ciências Médicas] ,Ciências Médicas::Medicina Clínica - Abstract
Overview and Aims: The introduction of antenatal RhD isoimmunization prophylaxis was of utmost importance in decreasing the prevalence of perinatal haemolytic disease. Noninvasive genotyping of fetal RhD group from mothers' plasma allows administration of anti-D immunoglobulin only to pregnant women with RhD positive fetuses. Aim: To analyse the economic impact of this technique in a population of nonisoimmunized pregnant women in comparison to the current practice of systematic RhD isoimmunization prophylaxis. Study design: Retrospective, observational and analytic study. Population: 9272 pregnant women who performed obstetric ultrasound in our Fetal Medicine and Prenatal Diagnosis Department between January 2007 to December 2012. Methods: The costs of systematic RhD isoimmunization prophylaxis were compared to fetal RhD genotyping and further RhD isoimunization of RhD negative mothers whose fetuses were RhD positive. Results:In the studied population, 16.7% of pregnant women were RhD negative and 40.3% of their offspring were also RhD negative. Concerning the economic analysis, selective administration of anti-D immunoglobulin based on fetal genotyping would have been about 62 euros more expensive per pregnancy than the current practice of antenatal immunoprophylaxis. Conclusion: Although non-invasive genotyping of fetal RhD group is undoubtly associated with innumerous benefits, in a merely economic analysis, this method is more expensive than the systematic immunoprophylaxis., info:eu-repo/semantics/publishedVersion
- Published
- 2015
21. Gestió d'horaris de recepció de mercaderia als magatzems reguladors d'una empresa del gran consum
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Abeijón Monjas, David, Torres Miranda, Alexandra, Abeijón Monjas, David, and Torres Miranda, Alexandra
- Published
- 2016
22. PERFIL EPIDEMIOLÓGICO DOS ÓBITOS E MANEJO REALIZADO PELO SERVIÇO DE FISIOTERAPIA EM PACIENTES QUE FORAM A ÓBITO POR COVID-19 INTERNADOS NA UTI DE UM HOSPITAL DE GRANDE PORTE DO DISTRITO FEDERAL.
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Alves Ribeiro, Mara Dayanne, Maia Pinto, Francisco José, Nascimento da Silva, Luan, Brito Oliveira, Sabrynna, Alves Ribeiro, Maria Dandara, Alves de Souza, Juliana, Marques de Miranda, Alexandra Mailane, and Araujo Silva, Jefferson Carlos
- Published
- 2023
23. Dermoid cyst in the previous caesarean section scar
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Maçães, Ana, primary, Rodrigues, Fedra, additional, Miranda, Alexandra, additional, and Rocha, Afonso, additional
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- 2015
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24. Adherence of older women with strength training and aerobic exercise.
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Miranda, Alexandra, Picorelli, Assumpção, Pereira, Daniele Sirineu, Felício, Diogo Carvalho, Dos Anjos, Daniela Maria, Gomes Pereira, Danielle Aparecida, Dias, Rosângela Corrêa, Assis, Marcella Guimarães, and Pereira, Leani Souza Máximo
- Subjects
OLDER women ,PATIENT compliance ,EXERCISE therapy ,MUSCLE strength testing ,AEROBIC exercises ,SCIENTIFIC observation ,REGRESSION analysis - Abstract
Background: Participation of older people in a program of regular exercise is an effective strategy to minimize the physical decline associated with age. The purpose of this study was to assess adherence rates in older women enrolled in two different exercise programs (one aerobic exercise and one strength training) and identify any associated clinical or functional factors. Methods: This was an exploratory observational study in a sample of 231 elderly women of mean age 70.5 years. We used a structured questionnaire with standardized tests to evaluate the relevant clinical and functional measures. A specific adherence questionnaire was developed by the researchers to determine motivators and barriers to exercise adherence. Results: The adherence rate was 49.70% in the aerobic exercise group and 56.20% in the strength training group. Multiple logistic regression models for motivation were significant (P=0.003) for the muscle strengthening group (R2=0.310) and also significant (P=0.008) for the aerobic exercise group (R2=0.154). A third regression model for barriers to exercise was significant (P=0.003) only for the muscle strengthening group (R2=0.236). The present study shows no direct relationship between worsening health status and poor adherence. Conclusion: Factors related to adherence with exercise in the elderly are multifactorial. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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25. Pneumotórax catamenial: uma apresentação atípica de endometriose
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Miranda, Alexandra Sofia Lopes, Cristina Nogueira-Silva, Abreu, Catia Lia, Cabrita, João Pedro Jordão Bentes, Pena, Domingos Jardim Da, and Universidade do Minho
- Subjects
Endometriosis ,Pneumothorax ,Pneumotórax ,Endometriose - Abstract
A endometriose torácica representa uma manifestação rara de endometriose, devendo ser considerada nas mulheres em idade reprodutiva que se apresentam com dor torácica, pneumotórax, hemotórax ou hemoptises coincidentes com a menstruação. Reportamos o caso clínico de uma mulher de 38 anos com dor torácica repetitiva e progressiva durante o cataménio, acompanhada de dispneia moderada e tosse não produtiva, com 4 anos de evolução. Foram confrmados imagiologicamente pneumotórax catameniais de repetição. Não obstante a ausência de evidência clínica de endometriose pélvica, estabeleceu-se como diagnóstico provável o pneumotórax catamenial associado a endometriose pleuro-pulmonar. Decidiu-se iniciar terapêutica com um agonista da hormona libertadora de gonadotrofnas, tendo-se verifcado remissão clínica dos sintomas respiratórios. A endometriose torácica é uma forma grave de apresentação da doença, requerendo o seu diagnóstico um grande índice de suspeição., info:eu-repo/semantics/publishedVersion
26. Characterisation of LVI-1 (WDR76) as a candidate tumour suppressor gene
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Miranda, Alexandra de Sousa Montenegro and Miranda, Alexandra de Sousa Montenegro
- Abstract
The central aim of this study was to characterise the expression of the candidate tumour suppressor gene, LV/-J (lentivirus integration-I] and its products. The LVI-J gene (WDR76) was discovered as a target for disruption by proviral insertional mutagenesis in a case of pre-B cell lymphoma in a FIV infected cat {Beatty, 1998 5 lid; Beatty, 2002 7 lid}. As LV/-J is highly conserved, my work focused on the human and murine orthologues to take advantage of the superior resources available for these species. My work showed potentially important differences in expression of the human and mouse genes with respect to promoter use and length of 3' untranslated sequences. The murine gene is transcribed mainly from the distal PI promoter, which appears to be a bi-directional element shared with the adjacent MJapJ gene, while the human gene transcripts are derived exclusively from the proximal P2 promoter. Direct analysis by RT-PCR showed that the murine gene could also be expressed from the P2 promoter. These findings have significant implications for Lvi-l protein expression as the P2 transcripts are predicted to express larger proteins with a distinct N-terminal sequence. To characterise the LV/-J gene products, rabbit polyclonal antisera were raised to GST fusion proteins expressed in bacteria. Use of the murine anti-ml.vi-I antiserum in Western blotting identified a protein of the expected size (58 kDa) based on translation of the major mRNA species from the PI promoter. Immunofluorescence and confocal microscopy suggested that this protein is localised mainly in the cytoplasm. Although the function of LVI-I is unknown, its closest relative in the human genome is DDB2, a protein involved in repair of UV-induced DNA damage. Regulation of LVI-I expression was examined after UV irradiation, providing preliminary evidence of responses at transcriptional and post-transcriptional levels. Further leads were followed by analogy with the yeast orthologue of LVI-I, YDLI56W, but no
27. Characterisation of LVI-1 (WDR76) as a candidate tumour suppressor gene
- Author
-
Miranda, Alexandra de Sousa Montenegro and Miranda, Alexandra de Sousa Montenegro
- Abstract
The central aim of this study was to characterise the expression of the candidate tumour suppressor gene, LV/-J (lentivirus integration-I] and its products. The LVI-J gene (WDR76) was discovered as a target for disruption by proviral insertional mutagenesis in a case of pre-B cell lymphoma in a FIV infected cat {Beatty, 1998 5 lid; Beatty, 2002 7 lid}. As LV/-J is highly conserved, my work focused on the human and murine orthologues to take advantage of the superior resources available for these species. My work showed potentially important differences in expression of the human and mouse genes with respect to promoter use and length of 3' untranslated sequences. The murine gene is transcribed mainly from the distal PI promoter, which appears to be a bi-directional element shared with the adjacent MJapJ gene, while the human gene transcripts are derived exclusively from the proximal P2 promoter. Direct analysis by RT-PCR showed that the murine gene could also be expressed from the P2 promoter. These findings have significant implications for Lvi-l protein expression as the P2 transcripts are predicted to express larger proteins with a distinct N-terminal sequence. To characterise the LV/-J gene products, rabbit polyclonal antisera were raised to GST fusion proteins expressed in bacteria. Use of the murine anti-ml.vi-I antiserum in Western blotting identified a protein of the expected size (58 kDa) based on translation of the major mRNA species from the PI promoter. Immunofluorescence and confocal microscopy suggested that this protein is localised mainly in the cytoplasm. Although the function of LVI-I is unknown, its closest relative in the human genome is DDB2, a protein involved in repair of UV-induced DNA damage. Regulation of LVI-I expression was examined after UV irradiation, providing preliminary evidence of responses at transcriptional and post-transcriptional levels. Further leads were followed by analogy with the yeast orthologue of LVI-I, YDLI56W, but no
28. Characterisation of LVI-1 (WDR76) as a candidate tumour suppressor gene
- Author
-
Miranda, Alexandra de Sousa Montenegro and Miranda, Alexandra de Sousa Montenegro
- Abstract
The central aim of this study was to characterise the expression of the candidate tumour suppressor gene, LV/-J (lentivirus integration-I] and its products. The LVI-J gene (WDR76) was discovered as a target for disruption by proviral insertional mutagenesis in a case of pre-B cell lymphoma in a FIV infected cat {Beatty, 1998 5 lid; Beatty, 2002 7 lid}. As LV/-J is highly conserved, my work focused on the human and murine orthologues to take advantage of the superior resources available for these species. My work showed potentially important differences in expression of the human and mouse genes with respect to promoter use and length of 3' untranslated sequences. The murine gene is transcribed mainly from the distal PI promoter, which appears to be a bi-directional element shared with the adjacent MJapJ gene, while the human gene transcripts are derived exclusively from the proximal P2 promoter. Direct analysis by RT-PCR showed that the murine gene could also be expressed from the P2 promoter. These findings have significant implications for Lvi-l protein expression as the P2 transcripts are predicted to express larger proteins with a distinct N-terminal sequence. To characterise the LV/-J gene products, rabbit polyclonal antisera were raised to GST fusion proteins expressed in bacteria. Use of the murine anti-ml.vi-I antiserum in Western blotting identified a protein of the expected size (58 kDa) based on translation of the major mRNA species from the PI promoter. Immunofluorescence and confocal microscopy suggested that this protein is localised mainly in the cytoplasm. Although the function of LVI-I is unknown, its closest relative in the human genome is DDB2, a protein involved in repair of UV-induced DNA damage. Regulation of LVI-I expression was examined after UV irradiation, providing preliminary evidence of responses at transcriptional and post-transcriptional levels. Further leads were followed by analogy with the yeast orthologue of LVI-I, YDLI56W, but no
29. Characterisation of LVI-1 (WDR76) as a candidate tumour suppressor gene
- Author
-
Miranda, Alexandra de Sousa Montenegro and Miranda, Alexandra de Sousa Montenegro
- Abstract
The central aim of this study was to characterise the expression of the candidate tumour suppressor gene, LV/-J (lentivirus integration-I] and its products. The LVI-J gene (WDR76) was discovered as a target for disruption by proviral insertional mutagenesis in a case of pre-B cell lymphoma in a FIV infected cat {Beatty, 1998 5 lid; Beatty, 2002 7 lid}. As LV/-J is highly conserved, my work focused on the human and murine orthologues to take advantage of the superior resources available for these species. My work showed potentially important differences in expression of the human and mouse genes with respect to promoter use and length of 3' untranslated sequences. The murine gene is transcribed mainly from the distal PI promoter, which appears to be a bi-directional element shared with the adjacent MJapJ gene, while the human gene transcripts are derived exclusively from the proximal P2 promoter. Direct analysis by RT-PCR showed that the murine gene could also be expressed from the P2 promoter. These findings have significant implications for Lvi-l protein expression as the P2 transcripts are predicted to express larger proteins with a distinct N-terminal sequence. To characterise the LV/-J gene products, rabbit polyclonal antisera were raised to GST fusion proteins expressed in bacteria. Use of the murine anti-ml.vi-I antiserum in Western blotting identified a protein of the expected size (58 kDa) based on translation of the major mRNA species from the PI promoter. Immunofluorescence and confocal microscopy suggested that this protein is localised mainly in the cytoplasm. Although the function of LVI-I is unknown, its closest relative in the human genome is DDB2, a protein involved in repair of UV-induced DNA damage. Regulation of LVI-I expression was examined after UV irradiation, providing preliminary evidence of responses at transcriptional and post-transcriptional levels. Further leads were followed by analogy with the yeast orthologue of LVI-I, YDLI56W, but no
30. Characterisation of LVI-1 (WDR76) as a candidate tumour suppressor gene
- Author
-
Miranda, Alexandra de Sousa Montenegro and Miranda, Alexandra de Sousa Montenegro
- Abstract
The central aim of this study was to characterise the expression of the candidate tumour suppressor gene, LV/-J (lentivirus integration-I] and its products. The LVI-J gene (WDR76) was discovered as a target for disruption by proviral insertional mutagenesis in a case of pre-B cell lymphoma in a FIV infected cat {Beatty, 1998 5 lid; Beatty, 2002 7 lid}. As LV/-J is highly conserved, my work focused on the human and murine orthologues to take advantage of the superior resources available for these species. My work showed potentially important differences in expression of the human and mouse genes with respect to promoter use and length of 3' untranslated sequences. The murine gene is transcribed mainly from the distal PI promoter, which appears to be a bi-directional element shared with the adjacent MJapJ gene, while the human gene transcripts are derived exclusively from the proximal P2 promoter. Direct analysis by RT-PCR showed that the murine gene could also be expressed from the P2 promoter. These findings have significant implications for Lvi-l protein expression as the P2 transcripts are predicted to express larger proteins with a distinct N-terminal sequence. To characterise the LV/-J gene products, rabbit polyclonal antisera were raised to GST fusion proteins expressed in bacteria. Use of the murine anti-ml.vi-I antiserum in Western blotting identified a protein of the expected size (58 kDa) based on translation of the major mRNA species from the PI promoter. Immunofluorescence and confocal microscopy suggested that this protein is localised mainly in the cytoplasm. Although the function of LVI-I is unknown, its closest relative in the human genome is DDB2, a protein involved in repair of UV-induced DNA damage. Regulation of LVI-I expression was examined after UV irradiation, providing preliminary evidence of responses at transcriptional and post-transcriptional levels. Further leads were followed by analogy with the yeast orthologue of LVI-I, YDLI56W, but no
31. Characterisation of LVI-1 (WDR76) as a candidate tumour suppressor gene
- Author
-
Miranda, Alexandra de Sousa Montenegro and Miranda, Alexandra de Sousa Montenegro
- Abstract
The central aim of this study was to characterise the expression of the candidate tumour suppressor gene, LV/-J (lentivirus integration-I] and its products. The LVI-J gene (WDR76) was discovered as a target for disruption by proviral insertional mutagenesis in a case of pre-B cell lymphoma in a FIV infected cat {Beatty, 1998 5 lid; Beatty, 2002 7 lid}. As LV/-J is highly conserved, my work focused on the human and murine orthologues to take advantage of the superior resources available for these species. My work showed potentially important differences in expression of the human and mouse genes with respect to promoter use and length of 3' untranslated sequences. The murine gene is transcribed mainly from the distal PI promoter, which appears to be a bi-directional element shared with the adjacent MJapJ gene, while the human gene transcripts are derived exclusively from the proximal P2 promoter. Direct analysis by RT-PCR showed that the murine gene could also be expressed from the P2 promoter. These findings have significant implications for Lvi-l protein expression as the P2 transcripts are predicted to express larger proteins with a distinct N-terminal sequence. To characterise the LV/-J gene products, rabbit polyclonal antisera were raised to GST fusion proteins expressed in bacteria. Use of the murine anti-ml.vi-I antiserum in Western blotting identified a protein of the expected size (58 kDa) based on translation of the major mRNA species from the PI promoter. Immunofluorescence and confocal microscopy suggested that this protein is localised mainly in the cytoplasm. Although the function of LVI-I is unknown, its closest relative in the human genome is DDB2, a protein involved in repair of UV-induced DNA damage. Regulation of LVI-I expression was examined after UV irradiation, providing preliminary evidence of responses at transcriptional and post-transcriptional levels. Further leads were followed by analogy with the yeast orthologue of LVI-I, YDLI56W, but no
32. Characterisation of LVI-1 (WDR76) as a candidate tumour suppressor gene
- Author
-
Miranda, Alexandra de Sousa Montenegro and Miranda, Alexandra de Sousa Montenegro
- Abstract
The central aim of this study was to characterise the expression of the candidate tumour suppressor gene, LV/-J (lentivirus integration-I] and its products. The LVI-J gene (WDR76) was discovered as a target for disruption by proviral insertional mutagenesis in a case of pre-B cell lymphoma in a FIV infected cat {Beatty, 1998 5 lid; Beatty, 2002 7 lid}. As LV/-J is highly conserved, my work focused on the human and murine orthologues to take advantage of the superior resources available for these species. My work showed potentially important differences in expression of the human and mouse genes with respect to promoter use and length of 3' untranslated sequences. The murine gene is transcribed mainly from the distal PI promoter, which appears to be a bi-directional element shared with the adjacent MJapJ gene, while the human gene transcripts are derived exclusively from the proximal P2 promoter. Direct analysis by RT-PCR showed that the murine gene could also be expressed from the P2 promoter. These findings have significant implications for Lvi-l protein expression as the P2 transcripts are predicted to express larger proteins with a distinct N-terminal sequence. To characterise the LV/-J gene products, rabbit polyclonal antisera were raised to GST fusion proteins expressed in bacteria. Use of the murine anti-ml.vi-I antiserum in Western blotting identified a protein of the expected size (58 kDa) based on translation of the major mRNA species from the PI promoter. Immunofluorescence and confocal microscopy suggested that this protein is localised mainly in the cytoplasm. Although the function of LVI-I is unknown, its closest relative in the human genome is DDB2, a protein involved in repair of UV-induced DNA damage. Regulation of LVI-I expression was examined after UV irradiation, providing preliminary evidence of responses at transcriptional and post-transcriptional levels. Further leads were followed by analogy with the yeast orthologue of LVI-I, YDLI56W, but no
33. Culture Shock steals the stage.
- Author
-
Miranda, Alexandra
- Published
- 2018
34. Sofrologia caycediana®: contributo para o tratamento da dor no doente oncológico
- Author
-
Campos, Marina, Rebelo, Pedro, and Miranda, Alexandra
- Subjects
Terapia da dor ,Relaxation ,Caycedian sophrology ,Pain therapy ,Medicina de reabilitação ,Relaxamento ,Rehabilitation ,Doente oncológico ,Cancer patient ,Sofrologia caycediana - Abstract
Mestrado em Fisioterapia O objetivo deste trabalho é apresentar a Sofrologia Caycediana® como um instrumento complementar para diminuição da dor oncológica em pacientes que sofrem de dor crónica. A Sofrologia Caycediana® é uma ciência com técnicas e métodos específicos. Estas técnicas podem ser adaptadas por cada profissional e para cada paciente. Permite também que o doente mantenha a força e a amplitude de movimento, pois o método inclui exercícios estáticos e dinâmicos; a Sofrologia dá ao doente a responsabilidade de trabalhar sozinho, definindo metas para a vida diária, tornando-o consciente do seu bem-estar e da capacidade para se ajudar a si mesmo e a ser parte de uma equipa. Esta ciência contém técnicas de relaxamento, uma forma holística para tratar e cuidar, fornecendo recursos para diminuir a dor, suportar a medicação e atenuar efeitos adversos da doença. Esta técnica pode ser aprendida por qualquer membro do pessoal de saúde envolvido no tratamento destes doentes. Família e cuidadores podem e devem estar envolvidos nas sessões. Ao longo da investigação realizada tomámos como dois campos fundamentais as intervenções farmacológicas e as não-farmacológicas (ou complementares) da dor. Em relação a dados demonstrando a evidência da Sofrologia, apenas foram encontrados quatro artigos, de médicos dentistas, que relatavam os resultados benéficos desta, em relação com outros métodos como a hipnose. A falta de achados não corresponde ao número de fisioterapeutas, formados e em formação, na Europa. Pode dever-se à exigência de evidência científica e à dificuldade em realizar protocolos nesse sentido que as Comissões de Ética aceitem, por se tratar de uma nova intervenção a que somente alguns grupos tenham acesso. No entanto, todos os colegas presentes nas sucessivas formações de atualização de carteira profissional em Sofrologia referem, unanimemente, a sua utilização diária, quer para fins individuais e de treino, quer com os doentes que seguem, obtendo excelentes resultados. Tem ficado evidente nos trabalhos apresentados, nomeadamente em 2014, para o evitar da queda no idoso, no tratamento do stress em ambiente de ensino-aprendizagem, entre outros. Este trabalho veio dar conta do vazio existente quer em relação ao tratamento multidisciplinar, sendo necessário a realização de trabalhos de investigação nas áreas de oncologia e da dor. ABSTRACT - The objective of this work is to introduce Caycedian Sophrology® as a complementary instrument for pain release in oncologic patients suffering from chronic pain. Caycedian Sophrology® is a relaxation technique, a holistic way to treat and care, providing resources to diminish pain and support the medication and adverse events of the illness. Is a science with specific methods and techniques. These techniques can be adapted to each professional and patient. It also allows the patient to maintain the strength and range of movement, as the method includes static and dynamic exercises; the method gives the patient the responsibility to work by himself, defining goals for daily life, conscious of his well-being and capacities to help himself and being part of a team. Caycedian Sophrology can be learned by any member of the health staff involved in the treatment of these patients. Family and caretakers can and should be involved in the sessions. Throughout the investigation we touch on two fundamental areas, the pharmacological and non-pharmacological (or complementary) interventions of pain. In this investigation we concluded that a void exists in relation to multidisciplinary treatment of pain, finding the necessity to carry out more research in the areas of Oncology and pain.
- Published
- 2015
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