1. Practice patterns for chronic hypoparathyroidism: data from patients and physicians in France
- Author
-
Bertocchio, Jean-Philippe, Grosset, Natalie, Groussin, Lionel, Kamenicky, Peter, Larceneux, Fabrice, Lienhardt-Roussie, Anne, Linglart, Agnès, Maruani, Gérard, Miralli, Eric, Pattou, François, Seervai, Riyad N.H., Sido, Coralie, Silve, Caroline, Vilfaillot, Aurélie, Tabarin, Antoine, Vantyghem, Marie-Christine, Houillier, Pascal, Beaume, Julie, Figueres, Lucile, Bobot, Mickaël, Laforcade, Louis, ayari, hamza, Dolley‐Hitze, Thibault, Gueutin, Victor, Braconnier, Antoine, Golbin, Léonard, Citarda, Salvatore, Seret, Guillaume, Belaïd, Lisa, Cohen, Raphaël, Luque, Yosu, Seervai, Riyad, Overs, Camille, Bertocchio, Jean‐Philippe, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre de Référence des Maladies Rares du Métabolisme du Phosphore et du Calcium and Filière de Santé Maladies Rares (OSCAR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Hypoparathyroïdisme France, Hôpital Cochin [AP-HP], Physiologie et physiopathologie endocriniennes (PHYSENDO), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Dauphine Recherches en Management (DRM), Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Service de Pédiatrie médicale [CHU Limoges], CHU Limoges, Hôpital Dupuytren [CHU Limoges], Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut des Maladies de l'Appareil Digestif, Université de Nantes (UN), Recherche translationnelle sur le diabète - U 1190 (RTD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Baylor College of Medicine (BCM), Baylor University, Thérapie génique, Génomique et Epigénomique (U 1169), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, CHU Bordeaux [Bordeaux], École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Physiologie et physiopathologie endocriniennes, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL), and HAL-SU, Gestionnaire
- Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,physicians ,Endocrinology, Diabetes and Metabolism ,hypoparathyroidism ,practice patterns ,030209 endocrinology & metabolism ,hypocalcemia ,RC648-665 ,Diseases of the endocrine glands. Clinical endocrinology ,3. Good health ,[SHS]Humanities and Social Sciences ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,[SHS.ENVIR]Humanities and Social Sciences/Environmental studies ,epidemiological studies ,Internal Medicine ,[SHS.GESTION]Humanities and Social Sciences/Business administration ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Context Recent guidelines have provided recommendations for the care of patients with chronic hypoparathyroidism. Very little is known about actual physicians’ practices or their adherence to such guidelines. Objective To describe the physicians’ practice patterns and their compliance with international guidelines. Design The cohort studies included were Épi-Hypo (118 physicians and 107 patients, from September 2016 to December 2019) and ePatients (110 patients, November 2019). Methods Internet-based cohorts involving all settings at a nationwide level (France). Participants were (i) physicians treating patients with chronic hypoparathyroidism and patients with chronic hypoparathyroidism either participating in the (ii) Épi-Hypo study (Épi-Hypo 2019 patients), or (iii) Hypoparathyroidism France, the national representative association (ePatients). Results The physicians’ specialties were mainly endocrinology (61%), nephrology (28%), family medicine (2.5%), pediatrics (2.5%), rheumatology (2%), or miscellaneous (4%) and 45% were practicing in public universities. The median number of pharmaceutical drug classes prescribed was three per patient. The combination of active vitamin D and calcium salt was given to 59 and 58% of ePatients and Épi-Hypo 2019 patients, respectively. Eighty-five percent of ePatients and 87% of physicians reported monitoring plasma calcium concentrations at a steady state at least twice a year. In 32 and 26% of cases, respectively, ePatients and physicians reported being fully in accordance with international guidelines that recommend targeting symptoms, plasma calcium and phosphate values, and urine calcium excretion. Conclusions The care of patients with chronic hypoparathyroidism involves physicians with very different practices, so guidelines should include and target other specialists as well as endocrinologists. Full adherence to the guidelines is low in France.
- Published
- 2021