216 results on '"Mirabelli, R."'
Search Results
2. Development of a novel neutron tracker for the characterisation of secondary neutrons emitted in Particle Therapy
- Author
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Gioscio, E., Battistoni, G., Bochetti, A., De Simoni, M., Dong, Y., Fischetti, M., Mattei, I., Mirabelli, R., Muraro, S., Patera, V., Sarti, A., Schiavi, A., Sciubba, A., Toppi, M., Traini, G., Valle, S.M., and Marafini, M.
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- 2020
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3. Tumor-non-tumor discrimination by a [formula omitted] detector for Radio Guided Surgery on ex-vivo neuroendocrine tumors samples
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Morganti, S., Bertani, E., Bocci, V., Colandrea, M., Collamati, F., Cremonesi, M., De Simoni, M., Ferrari, E., Fischetti, M., Funicelli, L., Grana, C.M., Mancini-Terracciano, C., Mirabelli, R., Papi, S., Pisa, E., Solfaroli-Camillocci, E., Traini, G., and Faccini, R.
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- 2020
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4. Charged particles and neutron trackers: Applications to particle therapy
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Mattei, I., Battistoni, G., De Simoni, M., Dong, Y., Embriaco, A., Fischetti, M., Gioscio, E., Mancini-Terracciano, C., Marafini, M., Mirabelli, R., Muraro, S., Sarti, A., Sciubba, A., Solfaroli Camillocci, E., Traini, G., Valle, S.M., and Patera, V.
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- 2020
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5. Test beam results of a fluorescence-based monitor for ultra-high dose rates
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Trigilio, A., primary, De Gregorio, A., additional, De Simoni, M., additional, Franciosini, G., additional, Garbini, M., additional, Magi, M., additional, Marafini, M., additional, Mirabelli, R., additional, Muscato, A., additional, Patera, V., additional, Schiavi, A., additional, Toppi, M., additional, Traini, G., additional, and Sarti, A., additional
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- 2024
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6. FOOT: a new experiment to measure nuclear fragmentation at intermediate energies
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Valle, S.M., Alexandrov, A., Ambrosi, G., Argirò, S., Battistoni, G., Belcari, N., Biondi, S., Bisogni, M.G., Bruni, G., Brambilla, S., Camarlinghi, N., Cerello, P., Ciarrocchi, E., Clozza, A., De Lellis, G., Di Crescenzo, A., Durante, M., Emde, M., Faccini, R., Ferrero, V., Ferroni, F., Finck, C., Francesconi, M., Franchini, M., Galli, L., Garbini, M., Giraudo, G., Hetzel, R., Iarocci, E., Ionica, M., Kanxheri, K., Lauria, A., La Tessa, C., Marafini, M., Mattei, I., Mirabelli, R., Montesi, M.C., Morone, M.C., Morrocchi, M., Muraro, S., Narici, L., Pastore, A., Pastrone, N., Patera, V., Pullia, M., Ramello, L., Rosso, V., Rovituso, M., Sanelli, C., Sarti, A., Sartorelli, G., Sato, O., Schiavi, A., Schuy, C., Scifoni, E., Sciubba, A., Selvi, M., Servoli, L., Sitta, M., Spighi, R., Spiriti, E., Sportelli, G., Stahl, A., Tommasino, F., Traini, G., Vanstalle, M., Villa, M., Weber, U., and Zoccoli, A.
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- 2019
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7. Review and performance of the Dose Profiler, a particle therapy treatments online monitor
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Traini, G., Mattei, I., Battistoni, G., Bisogni, M.G., De Simoni, M., Dong, Y., Embriaco, A., Fischetti, M., Magi, M., Mancini-Terracciano, C., Marafini, M., Mirabelli, R., Muraro, S., Patera, V., Schiavi, A., Sciubba, A., Solfaroli Camillocci, E., Valle, S.M., and Sarti, A.
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- 2019
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8. Secondary radiation measurements for particle therapy applications: Charged secondaries produced by 16O ion beams in a PMMA target at large angles
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Rucinski, A., Traini, G., Roldan, A. Baratto, Battistoni, G., De Simoni, M., Dong, Y., Fischetti, M., Frallicciardi, P.M., Gioscio, E., Mancini-Terracciano, C., Marafini, M., Mattei, I., Mirabelli, R., Muraro, S., Sarti, A., Schiavi, A., Sciubba, A., Solfaroli Camillocci, E., Valle, S.M., and Patera, V.
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- 2019
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9. The [formula omitted] radio-guided surgery: Method to estimate the minimum injectable activity from ex-vivo test
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Russomando, A., Schiariti, M., Bocci, V., Colandrea, M., Collamati, F., Cremonesi, M., Ferrari, M.E., Ferroli, P., Ghielmetti, F., Ghisini, R., Grana, C.M., Mancini Terracciano, C., Marafini, M., Mirabelli, R., Morganti, S., Papi, S., Patanè, M., Pedroli, G., Pollo, B., Solfaroli Camillocci, E., Traini, G., and Faccini, R.
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- 2019
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10. Characterisation of the MONDO detector response to neutrons by means of a FLUKA Monte Carlo simulation
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Giacometti, V., Battistoni, G., De Simoni, M., Dong, Y., Fischetti, M., Gioscio, E., Mattei, I., Mirabelli, R., Patera, V., Sarti, A., Sciubba, A., Traini, G., Valle, S.M., and Marafini, M.
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- 2018
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11. VHEE CONVENTIONAL AND FLASH TREATMENT PLANNING: THE CASE OF CHORDOMA AND MENINGIOMA LESIONS
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Muscato, A., primary, Battistoni, G., additional, Campana, L., additional, Carlotti, D., additional, De Felice, F., additional, De Gregorio, A., additional, De Simoni, M., additional, Di Felice, C., additional, Dong, Y., additional, Fischetti, M., additional, Franciosini, G., additional, Marafini, M., additional, Mattei, I., additional, Mirabelli, R., additional, Muraro, S., additional, Pacilio, M., additional, Palumbo, L., additional, Patera, V., additional, Schiavi, A., additional, Sciubba, A., additional, Schwarz, M., additional, Sorbino, S., additional, Tombolini, V., additional, Toppi, M., additional, Traini, G., additional, Trigilio, A., additional, and Sarti, A., additional
- Published
- 2023
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12. DEVELOPMENT OF A WEARABLE INDIVIDUAL DOSE MONITORING APPARATUS FOR INTERNAL DOSIMETRY IN TARGETED RADIONUCLIDE THERAPY
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Campana, L., primary, Ambrosino, A., additional, Cassano, B., additional, Collamati, F., additional, Faccini, R., additional, Iaccarino, G., additional, Terracciano, C. Mancini, additional, Mirabelli, R., additional, Morganti, S., additional, Nicolanti, F., additional, Pacilio, M., additional, Camillocci, E. Solfaroli, additional, and Soriani, A., additional
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- 2023
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13. New Advantage in Stereotactic Treatment of Lung and Pancreatic Cancer. Performance of Ultra-High Energy Electron (VHEE) Therapy Adjuvanted to the FLASH Effect: Clinical Implications and Treatment Plans Analysis
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Carlotti, D., primary, Muscato, A., additional, De Gregorio, A., additional, de Simoni, M., additional, Fiore, M., additional, Franciosini, G., additional, Insero, T., additional, Marafini, M., additional, Marè, V., additional, Mirabelli, R., additional, Palumbo, L., additional, Ramella, S., additional, Sarti, A., additional, Schiavi, A., additional, Toppi, M., additional, Traini, G., additional, Trigilio, A., additional, and Patera, V., additional
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- 2023
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14. Ion charge separation with new generation of nuclear emulsion films
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Montesi M.C., Lauria A., Alexandrov A., Solestizi L. Alunni, Giovanni Ambrosi, Argirò S., Diaz R. Arteche, Bartosik N., Battistoni G., Belcari N., Bellinzona E., Bianucci S., Biondi S., Bisogni M.G., Bruni G., Camarlinghi N., Carra P., Cerello P., Ciarrocchi E., Clozza A., Colombi S., Guerra A. Del, Simoni M. De, Crescenzo A. Di, Donetti M., Dong Y., Durante M., Embriaco A., Emde M., Faccini R., Ferrero V., Ferroni F., Fiandrini E., Finck C., Fiorina E., Fischetti M., Francesconi M., Franchini M., Galati G., Galli L., Garbini M., Gentile V., Giraudo G., Hetzel R., Iarocci E., Ionica M., Kanxheri K., Kraan A. C., Lante V., Tessa C. La, Torres E. Lopez, Marafini M., Mattei I., Mengarelli A., Mirabelli R., Moggi A., Morone M.C., Morrocchi M., Muraro S., Narici L., Pastore A., Pastrone N., Patera V., Pennazio F., Placidi P., Pullia M., Raffaelli F., Ramello L., Ridolfi R., Rosso V., Rovituso M., Sanelli C., Sarti A., Sartorelli G., Sato O., Savazzi S., Scavarda L., Schiavi A., Schuy C., Scifoni E., Sciubba A., Sécher A., Selvi M., Servoli L., Silvestre G., Sitta M., Spighi R., Spiriti E., Sportelli G., Stahl A., Tioukov V., Tomassini S., Tommasino F., Traini G., Valle S.M., Vanstalle M., Villa M., Weber U., Zoccoli A., and Lellis G. De
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charge identification ,nuclear emulsions ,charged particles therapy ,29.40.rg ,42.62.be ,Physics ,QC1-999 - Abstract
In hadron therapy, the accelerated ions, interacting with the body of the patient, cause the fragmentation of both projectile and target nuclei. The fragments interact with the human tissues depositing energy both in the entrance channel and in the volume surrounding the tumor. The knowledge of the fragments features is crucial to determine the energy amount deposited in the human body, and - hence - the damage to the organs and to the tissues around the tumor target.
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- 2019
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15. Inter-fractional monitoring of 12C ions treatments: results from a clinical trial at the CNAO facility
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Fischetti, M., Baroni, G., Battistoni, G., Bisogni, G., Cerello, P., Ciocca, M., De Maria, P., De Simoni, M., Di Lullo, B., Donetti, M., Dong, Y., Embriaco, A., Ferrero, V., Fiorina, E., Franciosini, G., Galante, F., Kraan, A., Luongo, C., Magi, M., Mancini-Terracciano, C., Marafini, M., Malekzadeh, E., Mattei, I., Mazzoni, E., Mirabelli, R., Mirandola, A., Morrocchi, M., Muraro, S., Patera, V., Pennazio, F., Schiavi, A., Sciubba, A., Solfaroli Camillocci, E., Sportelli, G., Tampellini, S., Toppi, M., Traini, G., Valle, S. M., Vischioni, B., Vitolo, V., and Sarti, A.
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- 2020
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16. Treatment planning of intracranial lesions with VHEE: comparing conventional and FLASH irradiation potential with state-of-the-art photon and proton radiotherapy
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Muscato, A., primary, Arsini, L., additional, Battistoni, G., additional, Campana, L., additional, Carlotti, D., additional, De Felice, F., additional, De Gregorio, A., additional, De Simoni, M., additional, Di Felice, C., additional, Dong, Y., additional, Franciosini, G., additional, Marafini, M., additional, Mattei, I., additional, Mirabelli, R., additional, Muraro, S., additional, Pacilio, M., additional, Palumbo, L., additional, Patera, V., additional, Schiavi, A., additional, Sciubba, A., additional, Schwarz, M., additional, Sorbino, S., additional, Tombolini, V., additional, Toppi, M., additional, Traini, G., additional, Trigilio, A., additional, and Sarti, A., additional
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- 2023
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17. Acrylates-based hydrophilic co-polymeric nanobeads as nanocarriers for imaging agents
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Cerra S., Dini V., Salamone T. A., Hajareh Haghighi F., Mercurio M., Cartoni A., Del Giudice A., Marsotto M., Venditti I., Battocchio C., Scaramuzzo F. A., Matassa R., Nottola S., Faccini R., Mirabelli R., Fratoddi I., Cerra, S., Dini, V., Salamone, T. A., Hajareh Haghighi, F., Mercurio, M., Cartoni, A., Del Giudice, A., Marsotto, M., Venditti, I., Battocchio, C., Scaramuzzo, F. A., Matassa, R., Nottola, S., Faccini, R., Mirabelli, R., and Fratoddi, I.
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Fluorescent polymeric nanoparticle, Morphostructural characterisation, Nanocarrier, Polymeric nanoparticle, Surfactant-free emulsion polymerization, Yttrium immobilisation - Published
- 2023
18. Characterization and optimization of a β detector for 18F radio-guided surgery
- Author
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Mirabelli, R., primary, Morganti, S., additional, Cartoni, A., additional, De Simoni, M., additional, Faccini, R., additional, Fischetti, M., additional, Giordano, A., additional, Scotognella, T., additional, Solfaroli-Camillocci, E., additional, and Collamati, F., additional
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- 2023
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19. MO-05.3 - DEVELOPMENT OF A WEARABLE INDIVIDUAL DOSE MONITORING APPARATUS FOR INTERNAL DOSIMETRY IN TARGETED RADIONUCLIDE THERAPY
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Campana, L., Ambrosino, A., Cassano, B., Collamati, F., Faccini, R., Iaccarino, G., Terracciano, C. Mancini, Mirabelli, R., Morganti, S., Nicolanti, F., Pacilio, M., Camillocci, E. Solfaroli, and Soriani, A.
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- 2023
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- View/download PDF
20. CO-02.2 - VHEE CONVENTIONAL AND FLASH TREATMENT PLANNING: THE CASE OF CHORDOMA AND MENINGIOMA LESIONS
- Author
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Muscato, A., Battistoni, G., Campana, L., Carlotti, D., De Felice, F., De Gregorio, A., De Simoni, M., Di Felice, C., Dong, Y., Fischetti, M., Franciosini, G., Marafini, M., Mattei, I., Mirabelli, R., Muraro, S., Pacilio, M., Palumbo, L., Patera, V., Schiavi, A., Sciubba, A., Schwarz, M., Sorbino, S., Tombolini, V., Toppi, M., Traini, G., Trigilio, A., and Sarti, A.
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- 2023
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- View/download PDF
21. Elemental fragmentation cross sections for a 16O beam of 400 MeV/u kinetic energy interacting with a graphite target using the FOOT ΔE-TOF detectors
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Toppi, M., Sarti, A., Alexandrov, A., Alpat, B., Ambrosi, G., Argirò, S., Diaz, R. A., Barbanera, M., Bartosik, N., Battistoni, G., Belcari, N., Biondi, S., Bisogni, M. G., Bon, M., Bruni, G., Carra, P., Cavanna, F., Cerello, P., Ciarrocchi, E., Clozza, A., Colombi, S., De Lellis, G., De Gregorio, A., Del Guerra, A., De Simoni, M., Di Crescenzo, A., Di Ruzza, B., Donetti, M., Dong, Y., Durante, M., Ferrero, V., Fiandrini, E., Finck, C., Fiorina, E., Fischetti, M., Francesconi, M., Franchini, M., Franciosini, G., Galati, G., Galli, L., Giraudo, G., Hetzel, Ronja Karin, Iarocci, E., Ionica, M., Iuliano, A., Kanxheri, K., Kraan, A. C., La Tessa, C., Laurenza, M., Lauria, A., Torres, E. L., Marafini, M., Massa, M., Massimi, C., Mattei, I., Meneghetti, A., Mengarelli, A., Mirabelli, R., Moggi, A., Montesi, M. C., Morone, M. C., Morrocchi, M., Muraro, S., Murtas, F., Muscato, A., Pastore, A., Pastrone, N., Patera, V., Pennazio, F., Peverini, F., Placidi, P., Pullia, M., Ramello, L., Reidel, C., Ridolfi, R., Rosso, V., Sanelli, C., Sartorelli, G., Sato, O., Savazzi, S., Scavarda, L., Schiavi, A., Schuy, C., Scifoni, E., Sciubba, A., Sécher, A., Selvi, M., Servoli, L., Silvestre, G., Sitta, M., Spighi, R., Spiriti, E., Sportelli, G., Stahl, Achim, Tomassini, S., Tommasino, F., Tioukov, V., Traini, G., Trigilio, A., Valle, S. M., Vanstalle, M., Weber, U., Zarrella, R., Zoccoli, A., Villa, M., Toppi, M, Sarti, A, Alexandrov, A, Alpat, B, Ambrosi, G, Argiro, S, Diaz, RA, Barbanera, M, Bartosik, N, Battistoni, G, Belcari, N, Biondi, S, Bisogni, MG, Bon, M, Bruni, G, Carra, P, Cavanna, F, Cerello, P, Ciarrocchi, E, Clozza, A, Colombi, S, De Lellis, G, De Gregorio, A, Del Guerra, A, De Simoni, M, Di Crescenzo, A, Di Ruzza, B, Donetti, M, Dong, Y, Durante, M, Ferrero, V, Fiandrini, E, Finck, C, Fiorina, E, Fischetti, M, Francesconi, M, Franchini, M, Franciosini, G, Galati, G, Galli, L, Giraudo, G, Hetzel, R, Iarocci, E, Ionica, M, Iuliano, A, Kanxheri, K, Kraan, AC, La Tessa, C, Laurenza, M, Lauria, A, Torres, EL, Marafini, M, Massa, M, Massimi, C, Mattei, I, Meneghetti, A, Mengarelli, A, Mirabelli, R, Moggi, A, Montesi, MC, Morone, MC, Morrocchi, M, Muraro, S, Murtas, F, Muscato, A, Pastore, A, Pastrone, N, Patera, V, Pennazio, F, Peverini, F, Placidi, P, Pullia, M, Ramello, L, Reidel, C, Ridolfi, R, Rosso, V, Sanelli, C, Sartorelli, G, Sato, O, Savazzi, S, Scavarda, L, Schiavi, A, Schuy, C, Scifoni, E, Sciubba, A, Secher, A, Selvi, M, Servoli, L, Silvestre, G, Sitta, M, Spighi, R, Spiriti, E, Sportelli, G, Stahl, A, Tomassini, S, Tommasino, F, Tioukov, V, Traini, G, Trigilio, A, Valle, SM, Vanstalle, M, Weber, U, Zarrella, R, Zoccoli, A, Villa, M, Toppi, M., Sarti, A., Alexandrov, A., Alpat, B., Ambrosi, G., Argirò, S., Diaz, R. A, Barbanera, M., Bartosik, N., Battistoni, G., Belcari, N., Biondi, S., Bisogni, M. G., Bon, M., Bruni, G., Carra, P., Cavanna, F., Cerello, P., Ciarrocchi, E., Clozza, A., Colombi, S., De Lellis, G., De Gregorio, A., Del Guerra, A., De Simoni, M., Di Crescenzo, A., Di Ruzza, B., Donetti, M., Dong, Y., Durante, M., Ferrero, V., Fiandrini, E., Finck, C., Fiorina, E., Fischetti, M., Francesconi, M., Franchini, M., Franciosini, G., Galati, G., Galli, L., Giraudo, G., Hetzel, R., Iarocci, E., Ionica, M., Iuliano, A., Kanxheri, K., Kraan, A. C., La Tessa, C., Laurenza, M., Lauria, A., Torres, E. L, Marafini, M., Massa, M., Massimi, C., Mattei, I., Meneghetti, A., Mengarelli, A., Mirabelli, R., Moggi, A., Montesi, M. C., Morone, M. C., Morrocchi, M., Muraro, S., Murtas, F., Muscato, A., Pastore, A., Pastrone, N., Patera, V., Pennazio, F., Peverini, F., Placidi, P., Pullia, M., Ramello, L., Reidel, C., Ridolfi, R., Rosso, V., Sanelli, C., Sartorelli, G., Sato, O., Savazzi, S., Scavarda, L., Schiavi, A., Schuy, C., Scifoni, E., Sciubba, A., Sécher, A., Selvi, M., Servoli, L., Silvestre, G., Sitta, M., Spighi, R., Spiriti, E., Sportelli, G., Stahl, A., Tomassini, S., Tommasino, F., Tioukov, V., Traini, G., Trigilio, A., Valle, S. M., Vanstalle, M., Weber, U., Zarrella, R., Zoccoli, A., and Villa, M.
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cross section ,Materials Science (miscellaneous) ,Settore FIS/07 ,timing detector ,Biophysics ,General Physics and Astronomy ,timing detectors ,fragmentation, cross section, timing detectors, particle therapy, space radioprotection ,particle therapy ,fragmentation ,ddc:530 ,Physical and Theoretical Chemistry ,space radioprotection ,Mathematical Physics - Abstract
Frontiers in physics 10, 979229 (2022). doi:10.3389/fphy.2022.979229 special issue: "Breakthrough in Particle Therapy: At the Edge of Physics, Biology and Medicine", Published by Frontiers Media, Lausanne
- Published
- 2022
22. GPU-accelerated Monte Carlo simulation of electron and photon interactions for radiotherapy applications
- Author
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Franciosini, G, primary, Battistoni, G, additional, Cerqua, A, additional, De Gregorio, A, additional, De Maria, P, additional, De Simoni, M, additional, Dong, Y, additional, Fischetti, M, additional, Marafini, M, additional, Mirabelli, R, additional, Muscato, A, additional, Patera, V, additional, Salvati, F, additional, Sarti, A, additional, Sciubba, A, additional, Toppi, M, additional, Traini, G, additional, Trigilio, A, additional, and Schiavi, A, additional
- Published
- 2023
- Full Text
- View/download PDF
23. Elemental fragmentation cross sections for a 16O beam of 400 MeV/u kinetic energy interacting with a graphite target using the FOOT ΔE-TOF detectors
- Author
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Toppi, M., primary, Sarti, A., additional, Alexandrov, A., additional, Alpat, B., additional, Ambrosi, G., additional, Argirò, S., additional, Diaz, R. A, additional, Barbanera, M., additional, Bartosik, N., additional, Battistoni, G., additional, Belcari, N., additional, Biondi, S., additional, Bisogni, M. G., additional, Bon, M., additional, Bruni, G., additional, Carra, P., additional, Cavanna, F., additional, Cerello, P., additional, Ciarrocchi, E., additional, Clozza, A., additional, Colombi, S., additional, De Lellis, G., additional, De Gregorio, A., additional, Del Guerra, A., additional, De Simoni, M., additional, Di Crescenzo, A., additional, Di Ruzza, B., additional, Donetti, M., additional, Dong, Y., additional, Durante, M., additional, Ferrero, V., additional, Fiandrini, E., additional, Finck, C., additional, Fiorina, E., additional, Fischetti, M., additional, Francesconi, M., additional, Franchini, M., additional, Franciosini, G., additional, Galati, G., additional, Galli, L., additional, Giraudo, G., additional, Hetzel, R., additional, Iarocci, E., additional, Ionica, M., additional, Iuliano, A., additional, Kanxheri, K., additional, Kraan, A.C., additional, La Tessa, C., additional, Laurenza, M., additional, Lauria, A., additional, Torres, E. L, additional, Marafini, M., additional, Massa, M., additional, Massimi, C., additional, Mattei, I., additional, Meneghetti, A., additional, Mengarelli, A., additional, Mirabelli, R., additional, Moggi, A., additional, Montesi, M.C., additional, Morone, M.C., additional, Morrocchi, M., additional, Muraro, S., additional, Murtas, F., additional, Muscato, A., additional, Pastore, A., additional, Pastrone, N., additional, Patera, V., additional, Pennazio, F., additional, Peverini, F., additional, Placidi, P., additional, Pullia, M., additional, Ramello, L., additional, Reidel, C., additional, Ridolfi, R., additional, Rosso, V., additional, Sanelli, C., additional, Sartorelli, G., additional, Sato, O., additional, Savazzi, S., additional, Scavarda, L., additional, Schiavi, A., additional, Schuy, C., additional, Scifoni, E., additional, Sciubba, A., additional, Sécher, A., additional, Selvi, M., additional, Servoli, L., additional, Silvestre, G., additional, Sitta, M., additional, Spighi, R., additional, Spiriti, E., additional, Sportelli, G., additional, Stahl, A., additional, Tomassini, S., additional, Tommasino, F., additional, Tioukov, V., additional, Traini, G., additional, Trigilio, A., additional, Valle, S.M., additional, Vanstalle, M., additional, Weber, U., additional, Zarrella, R., additional, Zoccoli, A., additional, and Villa, M., additional
- Published
- 2022
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- View/download PDF
24. The prognostic relevance of HER2-positivity gain in metastatic breast cancer in the ChangeHER trial
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Pizzuti, L, Barba, M, Mazzotta, M, Krasniqi, E, Maugeri-Sacca, M, Gamucci, T, Berardi, R, Livi, L, Ficorella, C, Natoli, C, Cortesi, E, Generali, D, La Verde, N, Cassano, A, Bria, E, Moscetti, L, Michelotti, A, Adamo, V, Zamagni, C, Tonini, G, Sergi, D, Marinelli, D, Paoletti, G, Tomao, S, Botticelli, A, Marchetti, P, Tinari, N, Grassadonia, A, Valerio, M, Mirabelli, R, Fabbri, M, D'Ostilio, N, Veltri, E, Corsi, D, Garrone, O, Paris, I, Sarobba, G, Meattini, I, Pistelli, M, Giotta, F, Lorusso, V, Garufi, C, Russo, A, Cazzaniga, M, Del Medico, P, Roselli, M, Vaccaro, A, Perracchio, L, di Benedetto, A, Daralioti, T, Sperduti, I, De Maria, R, Di Leo, A, Sanguineti, G, Ciliberto, G, Vici, P, Pizzuti L., Barba M., Mazzotta M., Krasniqi E., Maugeri-Sacca M., Gamucci T., Berardi R., Livi L., Ficorella C., Natoli C., Cortesi E., Generali D., La Verde N., Cassano A., Bria E., Moscetti L., Michelotti A., Adamo V., Zamagni C., Tonini G., Sergi D., Marinelli D., Paoletti G., Tomao S., Botticelli A., Marchetti P., Tinari N., Grassadonia A., Valerio M. R., Mirabelli R., Fabbri M. A., D'Ostilio N., Veltri E., Corsi D., Garrone O., Paris I., Sarobba G., Meattini I., Pistelli M., Giotta F., Lorusso V., Garufi C., Russo A., Cazzaniga M., Del Medico P., Roselli M., Vaccaro A., Perracchio L., di Benedetto A., Daralioti T., Sperduti I., De Maria R., Di Leo A., Sanguineti G., Ciliberto G., Vici P., Pizzuti, L, Barba, M, Mazzotta, M, Krasniqi, E, Maugeri-Sacca, M, Gamucci, T, Berardi, R, Livi, L, Ficorella, C, Natoli, C, Cortesi, E, Generali, D, La Verde, N, Cassano, A, Bria, E, Moscetti, L, Michelotti, A, Adamo, V, Zamagni, C, Tonini, G, Sergi, D, Marinelli, D, Paoletti, G, Tomao, S, Botticelli, A, Marchetti, P, Tinari, N, Grassadonia, A, Valerio, M, Mirabelli, R, Fabbri, M, D'Ostilio, N, Veltri, E, Corsi, D, Garrone, O, Paris, I, Sarobba, G, Meattini, I, Pistelli, M, Giotta, F, Lorusso, V, Garufi, C, Russo, A, Cazzaniga, M, Del Medico, P, Roselli, M, Vaccaro, A, Perracchio, L, di Benedetto, A, Daralioti, T, Sperduti, I, De Maria, R, Di Leo, A, Sanguineti, G, Ciliberto, G, Vici, P, Pizzuti L., Barba M., Mazzotta M., Krasniqi E., Maugeri-Sacca M., Gamucci T., Berardi R., Livi L., Ficorella C., Natoli C., Cortesi E., Generali D., La Verde N., Cassano A., Bria E., Moscetti L., Michelotti A., Adamo V., Zamagni C., Tonini G., Sergi D., Marinelli D., Paoletti G., Tomao S., Botticelli A., Marchetti P., Tinari N., Grassadonia A., Valerio M. R., Mirabelli R., Fabbri M. A., D'Ostilio N., Veltri E., Corsi D., Garrone O., Paris I., Sarobba G., Meattini I., Pistelli M., Giotta F., Lorusso V., Garufi C., Russo A., Cazzaniga M., Del Medico P., Roselli M., Vaccaro A., Perracchio L., di Benedetto A., Daralioti T., Sperduti I., De Maria R., Di Leo A., Sanguineti G., Ciliberto G., and Vici P.
- Abstract
In metastatic breast cancer (mBC), the change of human epidermal growth factor receptor 2 (HER2) status between primary and metastatic lesions is widely recognized, however clinical implications are unknown. Our study address the question if relevant differences exist between subjects who preserve the HER2 status and those who gain the HER2 positivity when relapsed. Data of patients affected by HER2-positive mBC, treated with pertuzumab and/or trastuzumab-emtansine (T-DM1) in a real-world setting at 45 Italian cancer centers were retrospectively collected and analyzed. From 2003 to 2017, 491 HER2‐positive mBC patients were included. Of these, 102 (20.7%) had been initially diagnosed as HER2-negative early BC. Estrogen and/or progesterone receptor were more expressed in patients with HER2-discordance compared to patients with HER2-concordant status (p < 0.0001 and p = 0.006, respectively). HER2-discordant tumors were characterized also by a lower rate of brain metastases (p = 0.01) and a longer disease free interval (p < 0.0001). Median overall survival was longer, although not statistically significant, in the subgroup of patients with HER2-discordant cancer with respect to patients with HER2-concordant status (140 vs 78 months, p = 0.07). Our findings suggest that patients with HER2-positive mBC with discordant HER2 status in early BC may have different clinical, biological and prognostic behavior compared to HER2-concordant patients.
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- 2021
25. Loss of HER2 and decreased T-DM1 efficacy in HER2 positive advanced breast cancer treated with dual HER2 blockade: the SePHER Study
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Bon, G, Pizzuti, L, Laquintana, V, Loria, R, Porru, M, Marchio, C, Krasniqi, E, Barba, M, Maugeri-Sacca, M, Gamucci, T, Berardi, R, Livi, L, Ficorella, C, Natoli, C, Cortesi, E, Generali, D, La Verde, N, Cassano, A, Bria, E, Moscetti, L, Michelotti, A, Adamo, V, Zamagni, C, Tonini, G, Barchiesi, G, Mazzotta, M, Marinelli, D, Tomao, S, Marchetti, P, Valerio, M, Mirabelli, R, Russo, A, Fabbri, M, D'Ostilio, N, Veltri, E, Corsi, D, Garrone, O, Paris, I, Sarobba, G, Giotta, F, Garufi, C, Cazzaniga, M, Del Medico, P, Roselli, M, Sanguineti, G, Sperduti, I, Sapino, A, De Maria, R, Leonetti, C, Di Leo, A, Ciliberto, G, Falcioni, R, Vici, P, Bon G., Pizzuti L., Laquintana V., Loria R., Porru M., Marchio C., Krasniqi E., Barba M., Maugeri-Sacca M., Gamucci T., Berardi R., Livi L., Ficorella C., Natoli C., Cortesi E., Generali D., La Verde N., Cassano A., Bria E., Moscetti L., Michelotti A., Adamo V., Zamagni C., Tonini G., Barchiesi G., Mazzotta M., Marinelli D., Tomao S., Marchetti P., Valerio M. R., Mirabelli R., Russo A., Fabbri M. A., D'Ostilio N., Veltri E., Corsi D., Garrone O., Paris I., Sarobba G., Giotta F., Garufi C., Cazzaniga M., Del Medico P., Roselli M., Sanguineti G., Sperduti I., Sapino A., De Maria R., Leonetti C., Di Leo A., Ciliberto G., Falcioni R., Vici P., Bon, G, Pizzuti, L, Laquintana, V, Loria, R, Porru, M, Marchio, C, Krasniqi, E, Barba, M, Maugeri-Sacca, M, Gamucci, T, Berardi, R, Livi, L, Ficorella, C, Natoli, C, Cortesi, E, Generali, D, La Verde, N, Cassano, A, Bria, E, Moscetti, L, Michelotti, A, Adamo, V, Zamagni, C, Tonini, G, Barchiesi, G, Mazzotta, M, Marinelli, D, Tomao, S, Marchetti, P, Valerio, M, Mirabelli, R, Russo, A, Fabbri, M, D'Ostilio, N, Veltri, E, Corsi, D, Garrone, O, Paris, I, Sarobba, G, Giotta, F, Garufi, C, Cazzaniga, M, Del Medico, P, Roselli, M, Sanguineti, G, Sperduti, I, Sapino, A, De Maria, R, Leonetti, C, Di Leo, A, Ciliberto, G, Falcioni, R, Vici, P, Bon G., Pizzuti L., Laquintana V., Loria R., Porru M., Marchio C., Krasniqi E., Barba M., Maugeri-Sacca M., Gamucci T., Berardi R., Livi L., Ficorella C., Natoli C., Cortesi E., Generali D., La Verde N., Cassano A., Bria E., Moscetti L., Michelotti A., Adamo V., Zamagni C., Tonini G., Barchiesi G., Mazzotta M., Marinelli D., Tomao S., Marchetti P., Valerio M. R., Mirabelli R., Russo A., Fabbri M. A., D'Ostilio N., Veltri E., Corsi D., Garrone O., Paris I., Sarobba G., Giotta F., Garufi C., Cazzaniga M., Del Medico P., Roselli M., Sanguineti G., Sperduti I., Sapino A., De Maria R., Leonetti C., Di Leo A., Ciliberto G., Falcioni R., and Vici P.
- Abstract
Background: HER2-targeting agents have dramatically changed the therapeutic landscape of HER2+ advanced breast cancer (ABC). Within a short time frame, the rapid introduction of new therapeutics has led to the approval of pertuzumab combined with trastuzumab and a taxane in first-line, and trastuzumab emtansine (T-DM1) in second-line. Thereby, evidence of T-DM1 efficacy following trastuzumab/pertuzumab combination is limited, with data from some retrospective reports suggesting lower activity. The purpose of the present study is to investigate T-DM1 efficacy in pertuzumab-pretreated and pertuzumab naïve HER2 positive ABC patients. We also aimed to provide evidence on the exposure to different drugs sequences including pertuzumab and T-DM1 in HER2 positive cell lines. Methods: The biology of HER2 was investigated in vitro through sequential exposure of resistant HER2 + breast cancer cell lines to trastuzumab, pertuzumab, and their combination. In vitro experiments were paralleled by the analysis of data from 555 HER2 + ABC patients treated with T-DM1 and evaluation of T-DM1 efficacy in the 371 patients who received it in second line. Survival estimates were graphically displayed in Kaplan Meier curves, compared by log rank test and, when possibile, confirmed in multivariate models. Results: We herein show evidence of lower activity of T-DM1 in two HER2+ breast cancer cell lines resistant to trastuzumab+pertuzumab, as compared to trastuzumab-resistant cells. Lower T-DM1 efficacy was associated with a marked reduction of HER2 expression on the cell membrane and its nuclear translocation. HER2 downregulation at the membrane level was confirmed in biopsies of four trastuzumab/pertuzumab-pretreated patients. Among the 371 patients treated with second-line T-DM1, median overall survival (mOS) from diagnosis of advanced disease and median progression-free survival to second-line treatment (mPFS2) were 52 and 6 months in 177 patients who received trastuzumab/pertuzumab in f
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- 2020
26. Distinct HR expression patterns significantly affect the clinical behavior of metastatic HER2+ breast cancer and degree of benefit from novel anti-HER2 agents in the real world setting
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Pizzuti, L, Krasniqi, E, Barchiesi, G, Della Giulia, M, Izzo, F, Sanguineti, G, Marchetti, P, Mazzotta, M, Giusti, R, Botticelli, A, Gamucci, T, Natoli, C, Grassadonia, A, Tinari, N, Iezzi, L, Tomao, S, Tomao, F, Tonini, G, Santini, D, Astone, A, Michelotti, A, De Angelis, C, Mentuccia, L, Vaccaro, A, Magnolfi, E, Gelibter, A, Magri, V, Cortesi, E, D'Onofrio, L, Cassano, A, Rossi, E, Cazzaniga, M, Moscetti, L, Omarini, C, Piacentini, F, Fabbri, M, Scinto, A, Corsi, D, Carbognin, L, Bria, E, La Verde, N, Samaritani, R, Garufi, C, Barni, S, Mirabelli, R, Sarmiento, R, Veltri, E, D'Auria, G, Paris, I, Giotta, F, Lorusso, V, Cardillo, F, Landucci, E, Mauri, M, Ficorella, C, Roselli, M, Adamo, V, Ricciardi, G, Russo, A, Berardi, R, Pistelli, M, Fiorio, E, Cannita, K, Sini, V, D'Ostilio, N, Foglietta, J, Greco, F, Zamagni, C, Garrone, O, Di Cocco, B, Baldini, E, Livi, L, Desideri, I, Meattini, I, Sarobba, G, Del Medico, P, De Tursi, M, Generali, D, De Maria, R, Risi, E, Ciliberto, G, Sperduti, I, Villa, A, Barba, M, Di Leo, A, Vici, P, Pizzuti L., Krasniqi E., Barchiesi G., Della Giulia M., Izzo F., Sanguineti G., Marchetti P., Mazzotta M., Giusti R., Botticelli A., Gamucci T., Natoli C., Grassadonia A., Tinari N., Iezzi L., Tomao S., Tomao F., Tonini G., Santini D., Astone A., Michelotti A., De Angelis C., Mentuccia L., Vaccaro A., Magnolfi E., Gelibter A., Magri V., Cortesi E., D'Onofrio L., Cassano A., Rossi E., Cazzaniga M., Moscetti L., Omarini C., Piacentini F., Fabbri M. A., Scinto A. F., Corsi D., Carbognin L., Bria E., La Verde N., Samaritani R., Garufi C., Barni S., Mirabelli R., Sarmiento R., Veltri E. M., D'Auria G., Paris I., Giotta F., Lorusso V., Cardillo F., Landucci E., Mauri M., Ficorella C., Roselli M., Adamo V., Ricciardi G. R. R., Russo A., Berardi R., Pistelli M., Fiorio E., Cannita K., Sini V., D'Ostilio N., Foglietta J., Greco F., Zamagni C., Garrone O., Di Cocco B., Baldini E., Livi L., Desideri I., Meattini I., Sarobba G., Del Medico P., De Tursi M., Generali D., De Maria R., Risi E., Ciliberto G., Sperduti I., Villa A., Barba M., Di Leo A., Vici P., Pizzuti, L, Krasniqi, E, Barchiesi, G, Della Giulia, M, Izzo, F, Sanguineti, G, Marchetti, P, Mazzotta, M, Giusti, R, Botticelli, A, Gamucci, T, Natoli, C, Grassadonia, A, Tinari, N, Iezzi, L, Tomao, S, Tomao, F, Tonini, G, Santini, D, Astone, A, Michelotti, A, De Angelis, C, Mentuccia, L, Vaccaro, A, Magnolfi, E, Gelibter, A, Magri, V, Cortesi, E, D'Onofrio, L, Cassano, A, Rossi, E, Cazzaniga, M, Moscetti, L, Omarini, C, Piacentini, F, Fabbri, M, Scinto, A, Corsi, D, Carbognin, L, Bria, E, La Verde, N, Samaritani, R, Garufi, C, Barni, S, Mirabelli, R, Sarmiento, R, Veltri, E, D'Auria, G, Paris, I, Giotta, F, Lorusso, V, Cardillo, F, Landucci, E, Mauri, M, Ficorella, C, Roselli, M, Adamo, V, Ricciardi, G, Russo, A, Berardi, R, Pistelli, M, Fiorio, E, Cannita, K, Sini, V, D'Ostilio, N, Foglietta, J, Greco, F, Zamagni, C, Garrone, O, Di Cocco, B, Baldini, E, Livi, L, Desideri, I, Meattini, I, Sarobba, G, Del Medico, P, De Tursi, M, Generali, D, De Maria, R, Risi, E, Ciliberto, G, Sperduti, I, Villa, A, Barba, M, Di Leo, A, Vici, P, Pizzuti L., Krasniqi E., Barchiesi G., Della Giulia M., Izzo F., Sanguineti G., Marchetti P., Mazzotta M., Giusti R., Botticelli A., Gamucci T., Natoli C., Grassadonia A., Tinari N., Iezzi L., Tomao S., Tomao F., Tonini G., Santini D., Astone A., Michelotti A., De Angelis C., Mentuccia L., Vaccaro A., Magnolfi E., Gelibter A., Magri V., Cortesi E., D'Onofrio L., Cassano A., Rossi E., Cazzaniga M., Moscetti L., Omarini C., Piacentini F., Fabbri M. A., Scinto A. F., Corsi D., Carbognin L., Bria E., La Verde N., Samaritani R., Garufi C., Barni S., Mirabelli R., Sarmiento R., Veltri E. M., D'Auria G., Paris I., Giotta F., Lorusso V., Cardillo F., Landucci E., Mauri M., Ficorella C., Roselli M., Adamo V., Ricciardi G. R. R., Russo A., Berardi R., Pistelli M., Fiorio E., Cannita K., Sini V., D'Ostilio N., Foglietta J., Greco F., Zamagni C., Garrone O., Di Cocco B., Baldini E., Livi L., Desideri I., Meattini I., Sarobba G., Del Medico P., De Tursi M., Generali D., De Maria R., Risi E., Ciliberto G., Sperduti I., Villa A., Barba M., Di Leo A., and Vici P.
- Abstract
We analyzed data from 738 HER2-positive metastatic breast cancer (mbc) patients treated with pertuzumab-based regimens and/or T-DM1 at 45 Italian centers. Outcomes were explored in relation to tumor subtype assessed by immunohistochemistry (IHC). The median progression-free survival at first-line (mPFS1) was 12 months. Pertuzumab as first-line conferred longer mPFS1 compared to other first-line treatments (16 vs. 9 months, p = 0.0001), regardless of IHC subtype. Median PFS in second-line (mPFS2) was 7 months, with no difference by IHC subtype, but it was more favorable with T-DM1 compared to other agents (7 vs. 6 months, p = 0.03). There was no PFS2 gain in patients with tumors expressing both hormonal receptors (HRs; p = 0.17), while a trend emerged for tumors with one HR (p = 0.05). Conversely, PFS2 gain was significant in HRs-negative tumors (p = 0.04). Median overall survival (mOS) was 74 months, with no significant differences by IHC subtypes. Survival rates at 2 and 3 years in patients treated with T-DM1 in second-line after pertuzumab were significantly lower compared to pertuzumab-naïve patients (p = 0.01). When analyzed by IHC subtype, the outcome was confirmed if both HRs or no HRs were expressed (p = 0.02 and p = 0.006, respectively). Our results confirm that HRs expression impacts the clinical behavior and novel treatment-related outcomes of HER2-positive tumors when treatment sequences are considered. Moreover, multivariate analysis showed that HRs expression had no effect on PFS and OS. Further studies are warranted to confirm our findings and clarify the interplay between HER2 and estrogen receptor pathways in HER2-positive (mbc) patients
- Published
- 2020
27. PO-1578 WIDMApp, an innovative approach for individual dose monitoring in Molecular Radiotherapy
- Author
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Mancini Terracciano, C., primary, Collamati, F., additional, Faccini, R., additional, Iaccarino, G., additional, Mirabelli, R., additional, Nicolanti, F., additional, Pacilio, M., additional, Soriani, A., additional, Campana, L., additional, and Solfaroli Camillocci, E., additional
- Published
- 2022
- Full Text
- View/download PDF
28. Hippocampal Sparing Radiotherapy in adults with Primary Brain Tumors: A comparative planning and dosimetric study using IMPT, IMRT and 3DCRT
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Aka, P, Taylor, R, Hugtenburg, R, Lambert, J, Powell, J, Bevolo, T, Gao, M, Gondi, V, Hartsell, W.H, Bolsi, A, Beer, J, Belosi, M.F, Siewert, D, Lomax, A.J, Weber, D.C, Huang, Y.J, Huang, C.C, Chao, P.J, Liu, C, Shang, H, Ding, X, Wang, Y, Mammar, H, Froelich, Sébastien, Alapetite, Claire, Bolle, Stéphanie, Calugaru, Valentin, Feuvret, Loic, Helfre, Sylvie, Champion, Laurence, Goudjil, Farid, Dendal, Remi, Engelholm, S.A, Munck Af Rosenschold, P, Kristensen, I, Smulders, B, Muhic, A, Alkner, S, Jacob, E, Engelholm, S, Aljabab, S, Lui, A, Wong, T, Liao, J, Laramore, G, Parvathaneni, U, Kharouta, M, Pidikiti, R, Jesseph, F, Smith, M, Dobbins, D, Mattson, D, Choi, S, Mansur, D, Machtay, M, Bhatt, A, Lütgendorf-Caucig, C, Dunavölgyi, R, Georg, P, Perpar, A, Fussl, C, Konstantinovic, R, Ulrike, M, Piero, F, Eugen, H, Vidal, M, Gerard, A, Barnel, C, Maneval, D, Herault, J, Claren, A, Doyen, J, Dendale, R, Toutee, A, Pasquie, I, Goudjil, F, Lumbroso Lerouic, L, Levy, C, Desjardins, L, Cassoux, N, Elisei, G, Pella, A, Calvi, G, Ricotti, R, Tagaste, B, Valvo, F, Ciocca, M, Via, R, Mastella, E, Baroni, G, Saotome, N, Yonai, S, Makishima, H, Hara, Y, Inaniwa, T, Sakama, M, Kanematsu, N, Tsuji, H, Furukawa, T, Shirai, T, Sauerwein, W, Finger, P.T, Gallie, B, Gavrylyuk, Y, Thariat, J, Salleron, J, Maschi, C, Fevrier, E, Caujolle, J.P, Hofverberg, P, Angellier, G, Peyrichon, M.L, Breneman, J, Esslinger, H, Pater, L, Vatner, R, Habrand, J.L, Stefan, D, Lesueur, P, Kao, W, Véla, A, Geffrelot, J, Tessonnier, T, Balosso, J, Mahé, M.A, Lim, P.S, Rompokos, V, Chang, Y.C, Royle, G, Gaze, M, Gains, J, Vennarini, S, Francesco, F, Rombi, B, Amichetti, M, Schwarz, M, Lorentini, S, Mee, T, Burnet, N.G, Crellin, A, Kirkby, N.F, Smith, E, Kirkby, K.J, Roggio, M, Buwenge, M, Melchionda, F, Ammendolia, I, Ronchi, L, Cammelli, S, Morganti, A.G, Youn, S.H, Kim, J.Y, Park, H.J, Shin, S.H, Lee, S.H, Hong, E.K, Czerska, K, Winczura, P, Wejs-Maternik, J, Blukis, A, Antonowicz-Szydlowska, M, Rucinski, A, Olko, P, Badzio, A, Kopec, R, Franceschini, D, Cozzi, L, De Rose, F, Meattini, I, Fogliata, A, Cozzi, S, Becherini, C, Tomatis, S, Livi, L, Scorsetti, M, Garda, A, Fattahi, S, Michel, A, Mutter, R, Yan, E, Park, S, Corbin, K, Giap, H, LAM, W.W, Geng, H, Tang, K.K, Lee, T.Y, Kong, C.W, Yang, B, Chiu, T.L, Cheung, K.Y, Yu, S.K, Ma, M, Gao, X, Zhao, Z, Zhao, B, Mullikin, T, Routman, D, Yu, J, Greco, K, Fagundes, M, Shan, J, Daniels, T, Rule, W, DeWees, T, Hu, Y, Bues, M, Sio, T, Liu, W, chenbin, L, yuehu, P, yuenan, W, Bai, Y, Gao, X.S, Zhao, Z.L, Ma, M.W, Ren, X.Y, Salem, A, Woolf, D, Aznar, M, Azadeh, A, Eccles, C, Charlwood, F, Faivre-Finn, C, Teoh, S, Fiorini, F, George, B, Vallis, K, Van den Heuvel, F, Huang, E.Y, Juang, P.J, Pan, S, Hawkins, M, Clarke, M, Lowe, M, Radhakrishna, G, Schaub, S, Bowen, S, Nyflot, M, Chapman, T, Apisarnthanarax, S, Vitek, P, Kubes, J, Vondracek, V, Vinakurau, S, Zamecnik, L, Vitolo, V, Barcellini, A, Brugnatelli, S, Cobianchi, L, Vanoli, A, 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Pike, L, Horick, N, Yeap, B, Franck, K, Wang, I, Loeffler, J, McKenna, M, Shih, H, Kountouri, M, Kole, A.J, Murray, F.R, Kliebsch, U, Combescure, C, iannalfi, A, Riva, G, Dougherty, J, Kruse, J, Iott, M, Brown, P, Olivier, K, Brodin, P, Kabarriti, R, Schechter, C, Kalnicki, S, Garg, M, Tomé, W, Lu, J.J, Chen, P.J, Dhanireddy, B, Severo, C, Lee, C.H, Lin, C.R, Rosier, L, Mathis, T, DeLaney, T, Lin, S, O’Meara, E, Powell, T, Hong, T, Hall, D, Liu, A, Ntentas, G, Dedeckova, K, Darby, S, Cutter, D, Zapletalova, S, Chen, Y.L, Miao, R, Lee, H, Hsiao-Ming, L, Choy, E, Cote, G, Eulitz, J, Lutz, B, Enghardt, W, Lühr, A, Mcmahon, S, Prise, K, Sung Hyun, L, Tansho, R, Mizushima, K, Warmenhoven, J.W, Hufnagl, A, Friedrich, T, Deycmar, S, Gruber, S, Dörr, W, Pruschy, M, Waissi, W, Burckel, H, Nicol, A, Noel, G, Yousef, I, Koizumi, M, Santa Cruz, G.A, González, S.J, Longhino, J, Provenzano, L, Oña, P, Rao, M, Cantarelli, M.D.L.Á, Leiras, A, Olivera, M.S, Alessandrini, P, Brollo, F, Boggio, E, Costa, H, Ventimiglia, R, Binia, S, Nievas, S.I, Langle, Y, Eijan, A.M, Colombo, L.L, Kawai, K, Nakamura, H, Natsuko, K, Masaki, H, Nakada, M, Furuse, M, Miyatake, S.I, Koivunoro, H, Kankaanranta, L, González, S, Joensuu, H, Sokol, O, Hild, S, Wiedemann, J, Köthe, A, Perry, D, Batie, M, Mascia, A, Sertorio, M, Luhr, A, Suckert, T, Müller, J, Beyreuther, E, Gotz, M, Haase, R, Schürer, M, Tillner, F, von Neubeck, C, Davis, A, Sishc, B, Saha, J, Ding, L, Story, M, Wagner, S, Kim, S.Y, Geary, S, Woodruff, T, Xu, T, Meng, Q, Gilchrist, S, Perentesis, J.P, Zheng, Y, Wells, S.I, Kong, Y, Liu, Y, Geng, Y, Knoll, M, Schwager, C, Schlegel, J, Schnölzer, M, Ding, L.H, Aroumougame, A, Chen, B, Saha, D, Pompos, A, Carter, R, Nickson, C, Thomson, J, Hill, M, Rodrigues, D, Snider, J, Sharma, A, Zakhary, M, Kara, L, Vujaskovic, Z, Dykstra, M, Best, T, Keane, F, Khandekar, M, Fintelmann, F, Willers, H, Singh, P, Eley, J, Malyapa, R, Mahmood, J, Hårdemark, B, Sandison, G.A, Wootton, L.S, Miyoaka, R.S, Laramore, G.E, Yang, P, van der Weide, H, Maduro, J, Heesters, M, Gawryszuk, A, Davila-Fajardo, R, Langendijk, H, Eckhard, M, Maxwell, A, VanNamen, K, Cashin, M, Jacovic, A, Dunn, M, kim, T, Jung, J, Kim, J, Swerdloff, S, Saunders, A, Thomas, J, Kidani, T, Okada, A, Tomida, K, Pennington, H, Xiaoqiang, L, Weigang, H, An, Q, Di, Y, Craig, S, Inga, G, Peyman, K, Xuanfeng, D, Cunningham, C, de Kock, M, Slabbert, J, Panaino, C.M, Phoenix, B, Regan, P.H, Shearman, R, Collins, S.M, Taylor, M.J, Grayson, M, Kato, K, Choi, H, Jang, J.W, Shin, W.G, Min, C.H, McMahon, S, Padilla Cabal, F, Fragoso, J.A, Resch, A.F, Katsis, A, Girdhani, S, Marshall, A, Jackson, I, Bentzen, S, Parry, R, Gantz, S, Schellhammer, S, Hoffmann, A, Delorme, R, Dos Santos, M, Salmon, R, Öden, J, Bullivant, K, Rucksdashal, R, Ferret, E, Covington, F, Rice, S, Decesaris, C, Siddiqui, O, Kowalski, E, Samanta, S, and Rothwell, B
- Subjects
Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0642 ,Physics: Absolute and Relative DosimetryPTC58-0180 ,Biology: Biology and Clinical InterfacePTC58-0685 ,Physics: Commissioning New FacilitiesPTC58-0385 ,Physics: 4D Treatment and DeliveryPTC58-0546 ,Clinics: EyePTC58-0714 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0528 ,Physics: Quality Assurance and VerificationPTC58-0507 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0661 ,Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0221 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0531 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0653 ,Biology: Drug and Immunotherapy CombinationsPTC58-0163 ,Clinics: Sarcoma - LymphomaPTC58-0055 ,Biology: Drug and Immunotherapy CombinationsPTC58-0166 ,Clinics: CNS / Skull BasePTC58-0198 ,Physics: Treatment PlanningPTC58-0421 ,Clinics: PediatricsPTC58-0560 ,General: New HorizonsPTC58-0709 ,Physics: Treatment PlanningPTC58-0664 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0286 ,Physics: Treatment PlanningPTC58-0666 ,Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0346 ,Physics: Treatment PlanningPTC58-0547 ,Physics: Treatment PlanningPTC58-0308 ,Physics: Treatment PlanningPTC58-0549 ,Physics: Beam Delivery and Nozzle Design Poster Discussion SessionsPTC58-0111 ,Physics: Absolute and Relative DosimetryPTC58-0050 ,Biology: Enhanced Biology in Treatment Planning Poster Discussion SessionsPTC58-0587 ,Biology: Biology and Clinical InterfacePTC58-0454 ,Physics: Absolute and Relative DosimetryPTC58-0052 ,Physics: Commissioning New FacilitiesPTC58-0395 ,Physics: 4D Treatment and DeliveryPTC58-0534 ,Physics: Dose Calculation and OptimisationPTC58-0072 ,Physics: 4D Treatment and DeliveryPTC58-0533 ,Physics: 4D Treatment and DeliveryPTC58-0538 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0113 ,Physics: Quality Assurance and VerificationPTC58-0633 ,Physics: Treatment PlanningPTC58-0431 ,Physics: Beam Delivery and Nozzle DesignPTC58-0230 ,Biology: Mathematical Modelling SimulationPTC58-0179 ,Clinics: Head and Neck / EyePTC58-0365 ,Physics: Treatment PlanningPTC58-0319 ,Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0697 ,Biology: Biology and Clinical InterfacePTC58-0663 ,Physics: Commissioning New FacilitiesPTC58-0240 ,Physics: Adaptive TherapyPTC58-0177 ,Physics: Commissioning New FacilitiesPTC58-0363 ,Physics: Commissioning New FacilitiesPTC58-0487 ,Physics: 4D Treatment and DeliveryPTC58-0209 ,Physics: 4D Treatment and DeliveryPTC58-0206 ,Clinics: CNS / Skull BasePTC58-0294 ,Physics: Commissioning New FacilitiesPTC58-0127 ,Biology: Mathematical Modelling SimulationPTC58-0068 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0062 ,Physics: 4D Treatment and DeliveryPTC58-0692 ,Physics: Quality Assurance and VerificationPTC58-0723 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0494 ,Physics: Treatment PlanningPTC58-0643 ,Physics: Treatment PlanningPTC58-0521 ,Physics: Treatment PlanningPTC58-0402 ,Physics: Treatment PlanningPTC58-0405 ,Clinics: Head and Neck / EyePTC58-0273 ,Clinics: GIPTC58-0397 ,Physics: Treatment PlanningPTC58-0648 ,Biology: Enhanced Biology in Treatment Planning Poster Discussion SessionsPTC58-0489 ,Physics: Quality Assurance and VerificationPTC58-0617 ,Physics: Quality Assurance and VerificationPTC58-0616 ,Physics: Dose Calculation and Optimisation Poster Discussion SessionsPTC58-0668 ,Clinics: CNS / Skull BasePTC58-0188 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0625 ,Physics: Treatment PlanningPTC58-0654 ,Physics: Treatment PlanningPTC58-0655 ,Biology: Drug and Immunotherapy Combinations Poster Discussion SessionsPTC58-0133 ,Clinics: PediatricsPTC58-0313 ,Physics: Treatment PlanningPTC58-0659 ,Poster AbstractsClinics: CNSPTC58-0290 ,Physics: Commissioning New FacilitiesPTC58-0064 ,Physics: Adaptive TherapyPTC58-0396 ,Physics: Dose Calculation and OptimisationPTC58-0281 ,Physics: Quality Assurance and VerificationPTC58-0427 ,Physics: Quality Assurance and VerificationPTC58-0669 ,General: New Horizons SessionPTC58-0191 ,Physics: Dose Calculation and Optimisation Poster Discussion SessionsPTC58-0217 ,Physics: Quality Assurance and VerificationPTC58-0303 ,Physics: Quality Assurance and VerificationPTC58-0665 ,Clinics: Sarcoma - LymphomaPTC58-0495 ,Physics: Dose Calculation and OptimisationPTC58-0398 ,Physics: Quality Assurance and VerificationPTC58-0667 ,Physics: Quality Assurance and VerificationPTC58-0425 ,Physics: Quality Assurance and VerificationPTC58-0541 ,Physics: Treatment PlanningPTC58-0584 ,Physics: Quality Assurance and VerificationPTC58-0540 ,Biology: Drug and Immunotherapy Combinations Poster Discussion SessionsPTC58-0163 ,Physics: Treatment PlanningPTC58-0224 ,Physics: Treatment PlanningPTC58-0229 ,Clinics: PediatricsPTC58-0249 ,Physics: Beam Delivery and Nozzle Design Poster Discussion SessionsPTC58-0555 ,Clinics: PediatricPTC58-0463 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0556 ,Physics: Absolute and Relative DosimetryPTC58-0498 ,Physics: Commissioning New FacilitiesPTC58-0078 ,Physics: Dose Calculation and OptimisationPTC58-0270 ,Physics: Dose Calculation and OptimisationPTC58-0032 ,Physics: Dose Calculation and OptimisationPTC58-0274 ,Physics: 4D Treatment and DeliveryPTC58-0614 ,Physics: Dose Calculation and OptimisationPTC58-0026 ,Clinics: Head and Neck / EyePTC58-0280 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0091 ,Physics: Treatment PlanningPTC58-0593 ,Biology: Drug and Immunotherapy CombinationsPTC58-0012 ,Physics: Dose Calculation and OptimisationPTC58-0025 ,Physics: Dose Calculation and OptimisationPTC58-0146 ,Clinics: Sarcoma - LymphomaPTC58-0261 ,Physics: Treatment PlanningPTC58-0110 ,Clinics: Lung / Sarcoma / LymphomaPTC58-0733 ,Physics: Quality Assurance and VerificationPTC58-0554 ,Physics: Treatment PlanningPTC58-0597 ,Physics: Dose Calculation and Optimisation Poster Discussion SessionsPTC58-0330 ,Physics: Treatment PlanningPTC58-0115 ,Physics: Treatment PlanningPTC58-0598 ,Physics: Absolute and Relative DosimetryPTC58-0040 ,Physics: Absolute and Relative DosimetryPTC58-0282 ,Biology: Enhanced Biology in Treatment Planning Poster Discussion SessionsPTC58-0399 ,Physics: Absolute and Relative DosimetryPTC58-0283 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0569 ,Clinics: GUPTC58-0647 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0506 ,Physics: Commissioning New FacilitiesPTC58-0047 ,Physics: Dose Calculation and OptimisationPTC58-0067 ,Clinics: GUPTC58-0409 ,Physics: Dose Calculation and OptimisationPTC58-0065 ,Biology: BNCT Poster Discussion SessionsPTC58-0586 ,Physics: Absolute and Relative Dosimetry PTC58-0393 ,Physics: Image GuidancePTC58-0712 ,Physics: Quality Assurance and VerificationPTC58-0645 ,Physics: Treatment PlanningPTC58-0683 ,Biology: BNCT Poster Discussion SessionsPTC58-0107 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0266 ,Physics: Monitoring and Modelling MotionPTC58-0530 ,Biology: BNCT Poster Discussion SessionsPTC58-0341 ,Physics: Commissioning New FacilitiesPTC58-0172 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0456 ,Physics: Dose Calculation and OptimisationPTC58-0170 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0458 ,Physics: Absolute and Relative DosimetryPTC58-0034 ,Physics: Quality Assurance and VerificationPTC58-0417 ,Physics: Quality Assurance and VerificationPTC58-0413 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0492 ,Physics: Dose Calculation and OptimisationPTC58-0168 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0724 ,Physics: Treatment PlanningPTC58-0694 ,Physics: Adaptive TherapyPTC58-0005 ,Physics: Treatment PlanningPTC58-0696 ,Physics: Treatment PlanningPTC58-0453 ,Physics: Adaptive TherapyPTC58-0366 ,Clinics: BreastPTC58-0197 ,Physics: Beam Delivery and Nozzle DesignPTC58-0652 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0017 ,Physics: Treatment PlanningPTC58-0338 ,Clinics: Head and Neck / EyePTC58-0539 ,General: New Horizons SessionPTC58-0390 ,Physics: Image Guidance Poster Discussion SessionsPTC58-0651 ,General: New HorizonsPTC58-0660 ,Physics: Dose Calculation and OptimisationPTC58-0360 ,Physics: Image GuidancePTC58-0297 ,Physics: 4D Treatment and DeliveryPTC58-0147 ,Scientific: RTTPTC58-0388 ,Physics: Dose Calculation and OptimisationPTC58-0484 ,General: New HorizonsPTC58-0301 ,Physics: Dose Calculation and OptimisationPTC58-0485 ,General: New HorizonsPTC58-0304 ,Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0532 ,Clinics: GIPTC58-0575 ,General: New HorizonsPTC58-0306 ,Physics: Quality Assurance and VerificationPTC58-0589 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0344 ,Physics: Quality Assurance and VerificationPTC58-0225 ,Physics: Treatment PlanningPTC58-0381 ,Physics: Quality Assurance and VerificationPTC58-0467 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0585 ,Physics: Commissioning New FacilitiesPTC58-0416 ,Physics: Quality Assurance and VerificationPTC58-0228 ,Physics: Quality Assurance and VerificationPTC58-0348 ,Physics: Dose Calculation and OptimisationPTC58-0234 ,Physics: Quality Assurance and VerificationPTC58-0101 ,Physics: Treatment PlanningPTC58-0386 ,Physics: Dose Calculation and OptimisationPTC58-0118 ,Physics: Treatment PlanningPTC58-0265 ,Physics: Dose Calculation and OptimisationPTC58-0119 ,Clinics: GIPTC58-0218 ,Physics: Treatment PlanningPTC58-0267 ,Physics: Treatment PlanningPTC58-0387 ,Clinics: BreastPTC58-0142 ,Physics: Treatment PlanningPTC58-0269 ,Physics: Beam Delivery and Nozzle DesignPTC58-0620 ,Clinics: PediatricsPTC58-0048 ,Physics: Quality Assurance and VerificationPTC58-0220 ,Physics: Quality Assurance and VerificationPTC58-0461 ,Physics: Treatment PlanningPTC58-0029 ,Physics: Absolute and Relative DosimetryPTC58-0571 ,Physics: Image GuidancePTC58-0046 ,Clinics: GUPTC58-0557 ,Physics: Absolute and Relative DosimetryPTC58-0211 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0131 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0373 ,General: New HorizonsPTC58-0411 ,Physics: Dose Calculation and OptimisationPTC58-0595 ,Clinics: CNS / Skull BasePTC58-0361 ,General: New HorizonsPTC58-0414 ,General: New HorizonsPTC58-0537 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0628 ,Physics: Treatment PlanningPTC58-0271 ,Physics: Commissioning New FacilitiesPTC58-0307 ,Physics: Quality Assurance and VerificationPTC58-0359 ,Physics: Quality Assurance and VerificationPTC58-0354 ,General: New HorizonsPTC58-0419 ,Physics: Treatment PlanningPTC58-0035 ,Biology: BNCTPTC58-0474 ,Clinics: GIPTC58-0460 ,Biology: BNCTPTC58-0596 ,Clinics: GIPTC58-0222 ,Physics: Image GuidancePTC58-0193 ,Clinics: PediatricPTC58-0312 ,Clinics: GUPTC58-0441 ,Clinics: LungPTC58-0701 ,Clinics: EyePTC58-0536 ,Clinics: GUPTC58-0205 ,Physics: Dose Calculation and OptimisationPTC58-0140 ,Clinics: GUPTC58-0208 ,Physics: Dose Calculation and OptimisationPTC58-0020 ,Physics: Image GuidancePTC58-0195 ,Poster AbstractsClinics: CNSPTC58-0717 ,Physics: Quality Assurance and VerificationPTC58-0325 ,Physics: Dose Calculation and OptimisationPTC58-0015 ,Physics: Commissioning New FacilitiesPTC58-0634 ,General: New HorizonsPTC58-0646 ,Physics: Quality Assurance and VerificationPTC58-0566 ,Physics: Dose Calculation and OptimisationPTC58-0134 ,Physics: Dose Calculation and OptimisationPTC58-0376 ,Biology: Mathematical Modelling SimulationPTC58-0462 ,Biology: BNCTPTC58-0567 ,General: New HorizonsPTC58-0527 ,Physics: Treatment PlanningPTC58-0482 ,Clinics: GI, GU, BreastPTC58-0693 ,Physics: Commissioning New FacilitiesPTC58-0518 ,Physics: Quality Assurance and VerificationPTC58-0686 ,Physics: Quality Assurance and VerificationPTC58-0202 ,Physics: Quality Assurance and VerificationPTC58-0322 ,Physics: Quality Assurance and VerificationPTC58-0564 ,Physics: Quality Assurance and VerificationPTC58-0680 ,Physics: Treatment PlanningPTC58-0247 ,Physics: Quality Assurance and VerificationPTC58-0682 ,Physics: Quality Assurance and VerificationPTC58-0440 ,Biology: Translational and BiomarkersPTC58-0514 ,Physics: Beam Delivery and Nozzle Design Poster Discussion SessionsPTC58-0178 ,Clinics: EyePTC58-0520 ,Physics: Absolute and Relative DosimetryPTC58-0231 ,Clinics: Head and Neck / EyePTC58-0424 ,Physics: Absolute and Relative DosimetryPTC58-0471 ,Physics: Absolute and Relative DosimetryPTC58-0356 ,Physics: Dose Calculation and OptimisationPTC58-0491 ,Physics: Dose Calculation and OptimisationPTC58-0250 ,Physics: Commissioning New FacilitiesPTC58-0650 ,Biology: Biology and Clinical InterfacePTC58-0719 ,Physics: Absolute and Relative DosimetryPTC58-0232 ,Physics: Absolute and Relative DosimetryPTC58-0353 ,General: New HorizonsPTC58-0511 ,Physics: Quality Assurance and VerificationPTC58-0219 ,Physics: Absolute and Relative DosimetryPTC58-0238 ,General: New HorizonsPTC58-0512 ,Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0401 ,Clinics: PediatricPTC58-0688 ,Physics: Quality Assurance and VerificationPTC58-0457 ,Physics: Quality Assurance and VerificationPTC58-0214 ,Physics: Quality Assurance and VerificationPTC58-0459 ,General: New HorizonsPTC58-0516 ,Physics: Treatment PlanningPTC58-0372 ,Physics: Treatment PlanningPTC58-0011 ,Physics: Treatment PlanningPTC58-0254 ,Physics: Quality Assurance and VerificationPTC58-0332 ,Clinics: CNS / Skull BasePTC58-0468 ,Biology: Mathematical Modelling SimulationPTC58-0357 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0649 ,Physics: Dose Calculation and OptimisationPTC58-0006 ,Physics: Quality Assurance and VerificationPTC58-0212 ,Physics: Image Guidance Poster Discussion SessionsPTC58-0565 ,Physics: Treatment PlanningPTC58-0018 ,Physics: Treatment PlanningPTC58-0019 ,Clinics: BreastPTC58-0576 ,Clinics: Head and Neck / EyePTC58-0335 ,Clinics: Head and Neck / EyePTC58-0577 ,General: New HorizonsPTC58-0621 ,Physics: Absolute and Relative DosimetryPTC58-0426 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0268 ,Physics: Absolute and Relative DosimetryPTC58-0423 ,Physics: Treatment PlanningPTC58-0184 ,Physics: Quality Assurance and VerificationPTC58-0149 ,Clinics: GIPTC58-0378 ,Clinics: GIPTC58-0257 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0662 ,General: New HorizonsPTC58-0627 ,Physics: Treatment PlanningPTC58-0186 ,Physics: Treatment PlanningPTC58-0185 ,Physics: Quality Assurance and VerificationPTC58-0144 ,Biology: BNCT Poster Discussion SessionsPTC58-0602 ,Physics: Treatment PlanningPTC58-0189 ,Physics: Dose Calculation and OptimisationPTC58-0315 ,Clinics: Head and neckPTC58-0300 ,General: New Horizons SessionPTC58-0347 ,Physics: Image GuidancePTC58-0082 ,Clinics: BreastPTC58-0443 ,Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0629 ,Physics: Adaptive Therapy Poster Discussion SessionsPTC58-0007 ,Physics: Commissioning New FacilitiesPTC58-0472 ,Clinics: GI, GU, BreastPTC58-0515 ,Physics: Dose Calculation and Optimisation Poster Discussion SessionsPTC58-0606 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0450 ,Physics: Absolute and Relative DosimetryPTC58-0657 ,Physics: Dose Calculation and OptimisationPTC58-0551 ,Physics: Treatment PlanningPTC58-0192 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0675 ,Physics: Treatment PlanningPTC58-0194 ,Physics: Dose Calculation and OptimisationPTC58-0544 ,Physics: Treatment PlanningPTC58-0199 ,Physics: Quality Assurance and VerificationPTC58-0037 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0207 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0434 ,Physics: Quality Assurance and VerificationPTC58-0036 ,Physics: Quality Assurance and VerificationPTC58-0278 ,Physics: Quality Assurance and VerificationPTC58-0394 ,Physics: Quality Assurance and VerificationPTC58-0151 ,Physics: Quality Assurance and VerificationPTC58-0154 ,Physics: Dose Calculation and OptimisationPTC58-0428 ,Clinics: BreastPTC58-0116 ,Biology: Enhanced Biology in Treatment Planning Poster Discussion SessionsPTC58-0435 ,Physics: Commissioning New FacilitiesPTC58-0681 ,Physics: Absolute and Relative DosimetryPTC58-0323 ,Physics: Dose Calculation and OptimisationPTC58-0583 ,Physics: Absolute and Relative DosimetryPTC58-0448 ,Clinics: CNS / Skull BasePTC58-0251 ,General: New HorizonsPTC58-0721 ,Physics: Absolute and Relative DosimetryPTC58-0203 ,Physics: Dose Calculation and OptimisationPTC58-0455 ,Physics: 4D Treatment and DeliveryPTC58-0130 ,Physics: Commissioning New FacilitiesPTC58-0679 ,Physics: Absolute and Relative DosimetryPTC58-0329 ,General: New HorizonsPTC58-0604 ,Physics: Absolute and Relative DosimetryPTC58-0449 ,Clinics: CNS / Skull BasePTC58-0132 ,General: New HorizonsPTC58-0607 ,Physics: Quality Assurance and VerificationPTC58-0122 ,Physics: Quality Assurance and VerificationPTC58-0243 ,Physics: Treatment PlanningPTC58-0165 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0437 ,Physics: 4D Treatment and DeliveryPTC58-0377 ,Physics: Quality Assurance and VerificationPTC58-0125 ,Physics: Quality Assurance and VerificationPTC58-0245 ,Physics: Dose Calculation and OptimisationPTC58-0337 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0334 ,Physics: Quality Assurance and VerificationPTC58-0121 ,General: New Horizons SessionPTC58-0563 ,General: New Horizons SessionPTC58-0321 ,Clinics: Head and Neck / EyePTC58-0477 ,Physics: Quality Assurance and VerificationPTC58-0480 ,Clinics: GUPTC58-0010 ,Clinics: EyePTC58-0684 ,Clinics: GUPTC58-0496 ,Clinics: Head and neckPTC58-0676 ,Clinics: GUPTC58-0137 ,Physics: Beam Delivery and Nozzle Design Poster Discussion SessionsPTC58-0256 ,Physics: 4D Treatment and DeliveryPTC58-0117 ,Physics: Absolute and Relative DosimetryPTC58-0552 ,Physics: Absolute and Relative DosimetryPTC58-0310 ,Physics: Absolute and Relative DosimetryPTC58-0672 ,Physics: Absolute and Relative DosimetryPTC58-0436 ,Physics: Dose Calculation and OptimisationPTC58-0452 ,Physics: Dose Calculation and OptimisationPTC58-0331 ,Physics: Commissioning New FacilitiesPTC58-0213 ,Biology: Mathematical Modelling SimulationPTC58-0272 ,Clinics: EyePTC58-0326 ,Physics: Commissioning New FacilitiesPTC58-0568 ,Physics: Dose Calculation and OptimisationPTC58-0444 ,Physics: Quality Assurance and VerificationPTC58-0379 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0095 ,Physics: Treatment PlanningPTC58-0053 ,Physics: Absolute and Relative DosimetryPTC58-0438 ,Physics: Absolute and Relative DosimetryPTC58-0317 ,Physics: Quality Assurance and VerificationPTC58-0497 ,Physics: Quality Assurance and VerificationPTC58-0375 ,Physics: Treatment PlanningPTC58-0056 ,Physics: 4D Treatment and DeliveryPTC58-0124 ,Clinics: GIPTC58-0009 ,Physics: Quality Assurance and VerificationPTC58-0014 ,Physics: Quality Assurance and VerificationPTC58-0374 ,Clinics: LungPTC58-0727 ,General: New Horizons SessionPTC58-0578 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0470 ,Clinics: LungPTC58-0204 ,Clinics: Head and neckPTC58-0227 ,Clinics: LungPTC58-0446 ,Physics: Quality Assurance and VerificationPTC58-0190 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0609 ,Clinics: LungPTC58-0689 ,General: New HorizonsPTC58-0021 ,General: New HorizonsPTC58-0262 ,Biology: BNCT Poster Discussion SessionsPTC58-0081 ,Clinics: GIPTC58-0726 ,General: New HorizonsPTC58-0145 ,Physics: Image GuidancePTC58-0573 ,General: New HorizonsPTC58-0027 ,General: New HorizonsPTC58-0028 ,Biology: Mathematical Modelling and SimulationPTC58-0148 ,Physics: Dose Calculation and OptimisationPTC58-0635 ,Physics: Image GuidancePTC58-0215 ,Physics: Image GuidancePTC58-0336 ,Poster AbstractsClinics: CNSPTC58-0535 ,Physics: Quality Assurance and VerificationPTC58-0187 ,Biology: BNCT Poster Discussion SessionsPTC58-0084 ,General: New Investigator SessionPTC58-0339 ,General: New Horizons SessionPTC58-0420 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0523 ,Biology: BNCT Poster Discussion SessionsPTC58-0088 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0112 ,Physics: Quality Assurance and VerificationPTC58-0182 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0615 ,Physics: Quality Assurance and VerificationPTC58-0080 ,Biology: BNCTPTC58-0085 ,Physics: Adaptive Therapy Poster Discussion SessionsPTC58-0722 ,General: New HorizonsPTC58-0253 ,General: New HorizonsPTC58-0255 ,Clinics: PediatricPTC58-0703 ,General: New HorizonsPTC58-0499 ,Physics: Image Guidance Poster Discussion SessionsPTC58-0380 ,General: New HorizonsPTC58-0259 ,Clinics: GI, GU, BreastPTC58-0288 ,Clinics: GI, GU, BreastPTC58-0045 ,Physics: Absolute and Relative DosimetryPTC58-0619 ,Clinics: PediatricPTC58-0707 ,Physics: Quality Assurance and VerificationPTC58-0196 ,Physics: Quality Assurance and VerificationPTC58-0074 ,Physics: Quality Assurance and VerificationPTC58-0077 ,Biology: BNCT Poster Discussion SessionsPTC58-0073 ,Biology: BNCTPTC58-0075 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0093 ,Clinics: GUPTC58-0161 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0371 ,Physics: Monitoring and Modelling MotionPTC58-0181 ,General: New HorizonsPTC58-0120 ,General: New HorizonsPTC58-0362 ,General: New HorizonsPTC58-0364 ,Physics: Image GuidancePTC58-0473 ,Scientific: RTTPTC58-0641 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0296 ,General: New HorizonsPTC58-0004 ,General: New HorizonsPTC58-0128 ,Clinics: BreastPTC58-0316 ,Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0236 ,General: New HorizonsPTC58-0008 ,General: New Investigator SessionPTC58-0673 ,Physics: Quality Assurance and VerificationPTC58-0167 ,Physics: Quality Assurance and VerificationPTC58-0289 ,Physics: Quality Assurance and VerificationPTC58-0284 ,General: New Horizons SessionPTC58-0522 ,Physics: Quality Assurance and VerificationPTC58-0164 ,Physics: Quality Assurance and VerificationPTC58-0285 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0623 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0502 ,Clinics: GUPTC58-0293 ,Biology: Translational and BiomarkersPTC58-0599 ,Biology: BNCTPTC58-0063 ,Clinics: LungPTC58-0656 ,General: New HorizonsPTC58-0592 ,Biology: BNCT Poster Discussion SessionsPTC58-0092 ,Poster AbstractsClinics: CNSPTC58-0302 ,Physics: Image GuidancePTC58-0464 ,General: New HorizonsPTC58-0352 ,Physics: Image GuidancePTC58-0465 ,General: New HorizonsPTC58-0476 ,Physics: Image GuidancePTC58-0100 ,General: New HorizonsPTC58-0235 ,Biology: Mathematical Modelling and SimulationPTC58-0349 ,Physics: Treatment PlanningPTC58-0094 ,Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0367 ,Physics: Dose Calculation and OptimisationPTC58-0400 ,Biology: Translational and BiomarkersPTC58-0244 ,Physics: Dose Calculation and OptimisationPTC58-0640 ,Biology: Mathematical Modelling and SimulationPTC58-0355 ,General: New Investigator SessionPTC58-0320 ,Physics: Quality Assurance and VerificationPTC58-0057 ,Physics: Quality Assurance and VerificationPTC58-0174 ,Physics: Quality Assurance and VerificationPTC58-0295 ,Physics: Dose Calculation and OptimisationPTC58-0529 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0123 ,Physics: Quality Assurance and VerificationPTC58-0171 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0049 ,Clinics: BreastPTC58-0731 ,General: New HorizonsPTC58-0223 ,General: New HorizonsPTC58-0102 ,General: New HorizonsPTC58-0466 ,Scientific: RTTPTC58-0503 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0389 ,General: New HorizonsPTC58-0108 ,General: New HorizonsPTC58-0109 ,Physics: Commissioning New FacilitiesPTC58-0736 ,Biology: Mathematical Modelling and SimulationPTC58-0343 ,Biology: Mathematical Modelling and SimulationPTC58-0342 ,Clinics: GI, GU, BreastPTC58-0237 ,Physics: Dose Calculation and OptimisationPTC58-0711 ,Biology: Mathematical Modelling and SimulationPTC58-0581 ,Clinics: GI, GU, BreastPTC58-0114 ,Clinics: Base of SkullPTC58-0730 ,Clinics: Head and neckPTC58-0383 ,Clinics: CNS / Skull BasePTC58-0559 ,Clinics: Base of SkullPTC58-0613 ,General: New HorizonsPTC58-0691 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0054 ,General: New HorizonsPTC58-0210 ,Clinics: BreastPTC58-0729 ,General: New HorizonsPTC58-0574 ,Clinics: GI, GU, BreastPTC58-0239 ,Scientific: RTTPTC58-0637 ,General: New HorizonsPTC58-0579 ,Clinics: Lung / Sarcoma / LymphomaPTC58-0176 ,General: New HorizonsPTC58-0699 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0156 ,Biology: Mathematical Modelling and SimulationPTC58-0333 ,Biology: Translational and BiomarkersPTC58-0345 ,Physics: Image GuidancePTC58-0369 ,Physics: Commissioning New FacilitiesPTC58-0509 ,Biology: Mathematical Modelling SimulationPTC58-0658 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0051 ,General: New Investigator SessionPTC58-0548 ,Clinics: GI, GU, BreastPTC58-0241 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0412 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0024 ,Clinics: LungPTC58-0226 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0069 ,General: New HorizonsPTC58-0562 ,General: New HorizonsPTC58-0561 ,General: New HorizonsPTC58-0201 ,Biology: Mathematical Modelling and SimulationPTC58-0439 ,General: New HorizonsPTC58-0445 ,General: New HorizonsPTC58-0324 ,Physics: Image GuidancePTC58-0031 ,Biology: Mathematical Modelling and SimulationPTC58-0558 ,Physics: Image GuidancePTC58-0392 ,Biology: Mathematical Modelling and SimulationPTC58-0678 ,Physics: Beam Delivery and Nozzle DesignPTC58-0090 ,General: New Investigator SessionPTC58-0630 ,Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0524 ,Physics: Commissioning New FacilitiesPTC58-0713 ,Clinics: GI, GU, BreastPTC58-0139 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0248 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0368 ,Biology: Enhanced Biology in Treatment PlanningPTC58-0519 ,General: New Horizons SessionPTC58-0720 ,Physics: Quality Assurance and VerificationPTC58-0083 ,General: New HorizonsPTC58-0311 ,General: New HorizonsPTC58-0674 ,General: New HorizonsPTC58-0553 ,Physics: Image GuidancePTC58-0023 ,Scientific: RTTPTC58-0612 ,General: New HorizonsPTC58-0677 ,Biology: Mathematical Modelling and SimulationPTC58-0545 ,Physics: Dose Calculation and OptimisationPTC58-0601 ,Physics: Dose Calculation and OptimisationPTC58-0725 ,Physics: Quality Assurance and VerificationPTC58-0098 ,Physics: Dose Calculation and OptimisationPTC58-0605 ,Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0517 ,Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0618 ,Physics: Monitoring and Modelling MotionPTC58-0481 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0071 ,Physics: Adaptive TherapyPTC58-0351 ,Physics: 4D Treatment and DeliveryPTC58-0702 ,Physics: Image GuidancePTC58-0734 ,Physics: Image GuidancePTC58-0611 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0486 ,Physics: Absolute and Relative Dosimetry Poster Discussion SessionsPTC58-0442 ,Biology: Drug and Immunotherapy CombinationsPTC58-0327 ,Clinics: Head and Neck / EyePTC58-0096 ,Clinics: LungPTC58-0159 ,Physics: Treatment PlanningPTC58-0708 ,General: New HorizonsPTC58-0097 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0350 ,Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0016 ,Physics: Adaptive TherapyPTC58-0104 ,Physics: Absolute and Relative Dosimetry Poster Discussion SessionsPTC58-0433 ,Physics: Image GuidancePTC58-0608 ,Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0610 ,Clinics: Head and neckPTC58-0058 ,Physics: Treatment PlanningPTC58-0715 ,Clinics: Head and neckPTC58-0298 ,Clinics: EyePTC58-0099 ,General: New HorizonsPTC58-0086 ,General: New HorizonsPTC58-0089 ,Clinics: Lung / Sarcoma / LymphomaPTC58-0200 ,Poster AbstractsClinics: CNSPTC58-0157 ,Clinics: LungPTC58-0141 ,Clinics: LungPTC58-0260 ,Clinics: LungPTC58-0264 ,Physics: Image GuidancePTC58-0513 ,Physics: Image GuidancePTC58-0631 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0469 ,Biology: BNCT Poster Discussion SessionsPTC58-0384 ,Physics: Image GuidancePTC58-0639 ,Clinics: PediatricsPTC58-0700 ,Clinics: LungPTC58-0136 ,Clinics: BreastPTC58-0706 ,General: New HorizonsPTC58-0079 ,Biology: Drug and Immunotherapy Combinations Poster Discussion SessionsPTC58-0406 ,Clinics: Base of SkullPTC58-0382 ,Physics: Image GuidancePTC58-0624 ,Physics: Beam Delivery and Nozzle DesignPTC58-0173 ,Biology: Drug and Immunotherapy CombinationsPTC58-0358 ,Poster AbstractsClinics: CNSPTC58-0690 ,General: New HorizonsPTC58-0061 ,Clinics: Lung / Sarcoma / LymphomaPTC58-0580 ,Physics: Monitoring and Modelling MotionPTC58-0162 ,Physics: Adaptive TherapyPTC58-0550 ,Physics: Adaptive TherapyPTC58-0430 ,Clinics: Lung / Sarcoma / LymphomaPTC58-0103 ,General: New Investigator SessionPTC58-0252 ,Physics: Quality Assurance and VerificationPTC58-0704 ,Physics: Image GuidancePTC58-0418 ,Clinics: Base of SkullPTC58-0572 ,Clinics: Lung / Sarcoma / LymphomaPTC58-0106 ,Physics: Beam Delivery and Nozzle DesignPTC58-0022 ,Physics: Monitoring and Modelling MotionPTC58-0279 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0447 ,Physics: Treatment PlanningPTC58-0622 ,Clinics: PediatricsPTC58-0644 ,Biology: Biology and Clinical InterfacePTC58-0490 ,Clinics: CNS / Skull BasePTC58-0716 ,General: New HorizonsPTC58-0292 ,Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0570 ,General: New HorizonsPTC58-0059 ,Physics: Quality Assurance and VerificationPTC58-0710 ,Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0216 ,Physics: Image GuidancePTC58-0404 ,Physics: Image GuidancePTC58-0525 ,Physics: Image GuidancePTC58-0526 ,Poster AbstractsClinics: CNSPTC58-0328 ,Clinics: LungPTC58-0070 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0135 ,Biology: BNCT Poster Discussion SessionsPTC58-0391 ,Physics: Treatment PlanningPTC58-0510 ,Physics: Treatment PlanningPTC58-0636 ,Physics: Treatment PlanningPTC58-0638 ,Physics: Image GuidancePTC58-0408 ,Physics: Absolute and Relative Dosimetry Poster Discussion SessionsPTC58-0632 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0318 ,Biology: Enhanced Biology in Treatment PlanningPTC58-0246 ,Clinics: PediatricsPTC58-0504 ,General: New HorizonsPTC58-0160 ,Physics: Image Guidance Poster Discussion SessionsPTC58-0076 ,Physics: Monitoring and Modelling MotionPTC58-0143 ,Biology: Mathematical Modelling and SimulationPTC58-0718 ,Physics: Image GuidancePTC58-0671 ,Clinics: LungPTC58-0183 ,Physics: Image GuidancePTC58-0670 ,Report ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0422 ,Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0129 ,Physics: Adaptive Therapy Poster Discussion SessionsPTC58-0705 ,Biology: Enhanced Biology in Treatment PlanningPTC58-0258 ,General: New HorizonsPTC58-0030 ,General: New HorizonsPTC58-0150 ,Biology: Biology and Clinical InterfacePTC58-0479 ,General: New HorizonsPTC58-0153 ,Clinics: PediatricPTC58-0087 ,General: New HorizonsPTC58-0152 ,General: New HorizonsPTC58-0155 ,General: New HorizonsPTC58-0033 ,General: New HorizonsPTC58-0158 ,Physics: Image GuidancePTC58-0429 ,Biology: Translational and BiomarkersPTC58-0287 ,Physics: Adaptive TherapyPTC58-0403 ,Physics: Image GuidancePTC58-0309 - Published
- 2020
29. Clinical relevance and treatment of nonautoimmune anemia in chronic lymphocytic leukemia
- Author
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Molica S, Mirabelli R, Molica M, Levato L, Mauro F, and Foà R
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Stefano Molica1, Rosanna Mirabelli1, Matteo Molica1, Luciano Levato1, Francesca R Mauro2, Robin Foà21Department of Hematology and Oncology, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro; 2Department of Cellular Biotechnologies and Hematology, Division of Hematology, Sapienza University, Rome, ItalyAbstract: Anemia has an unfavorable impact on quality of life in chronic lymphocytic leukemia (CLL), increases the likelihood of receiving blood transfusions, and eventually has a negative impact on overall survival. Although discrepancies in perception of health-related quality of life between doctors and patients lead to the undertreatment of anemia, CLL patients undergoing chemotherapy who have a hemoglobin level
- Published
- 2011
30. In-vivo inter-fractional monitoring in particle therapy with the INSIDE in-beam PET
- Author
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Ferrero, V., primary, Battistoni, G., additional, Belcari, N., additional, Berti, A., additional, Bisogni, G., additional, Cerello, P., additional, Ciocca, M., additional, De Simoni, M., additional, Donetti, M., additional, Dong, Y., additional, Egidi, I., additional, Embriaco, A., additional, Fiorina, E., additional, Fischetti, M., additional, Franciosini, G., additional, Kraan, A., additional, Giraudo, G., additional, Laruina, F., additional, Luongo, C., additional, Magi, M., additional, Malekzadeh, E., additional, Mancini-Terracciano, C., additional, Marafini, M., additional, Mattei, I., additional, Mazzoni, E., additional, Mirabelli, R., additional, Morrocchi, M., additional, Muraro, S., additional, Patera, A., additional, Patera, V., additional, Pennazio, F., additional, Retico, A., additional, Rivetti, A., additional, Rolo, M.D., additional, Rosso, V., additional, Sarti, A., additional, Schiavi, A., additional, Sciubba, A., additional, Camillocci, E. Solfaroli, additional, Sportelli, G., additional, Tampellini, S., additional, Toppi, M., additional, Traini, G., additional, Trigilio, A., additional, Valle, S.M., additional, Valvo, F., additional, Vitolo, V., additional, and Wheadon, R., additional
- Published
- 2021
- Full Text
- View/download PDF
31. Inter-fractional monitoring in particle therapy treatments with 12C exploiting the detection of secondary particles: preliminary clinical trial results at the CNAO facility
- Author
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Fischetti, M., primary, Battistoni, G., additional, Bisogni, G., additional, Cerello, P., additional, Ciocca, M., additional, De Simoni, M., additional, Di Lullo, B., additional, Donetti, M., additional, Dong, Y., additional, Embriaco, A., additional, Ferrero, V., additional, Fiorina, E., additional, Franciosini, G., additional, Kraan, A.C., additional, Luongo, C., additional, Magi, M., additional, Mancini-Terracciano, C., additional, Marafini, M., additional, Mattei, I., additional, Mirabelli, R., additional, Muraro, S., additional, Patera, V., additional, Pennazio, F., additional, Schiavi, A., additional, Sciubba, A., additional, Camillocci, E. Solfaroli, additional, Sportelli, G., additional, Tampellini, S., additional, Toppi, M., additional, Traini, G., additional, Valle, S.M., additional, Vitolo, V., additional, and Sarti, A., additional
- Published
- 2021
- Full Text
- View/download PDF
32. FRED: a fast Monte Carlo code on GPU for treatment planning software
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De Simoni, M., primary, De Maria, P., additional, Fischetti, M., additional, Franciosini, G., additional, Marafini, M., additional, Mirabelli, R., additional, Patera, V., additional, Salvati, F., additional, Sarti, A., additional, Schiavi, A., additional, Sciubba, A., additional, and Traini, G., additional
- Published
- 2021
- Full Text
- View/download PDF
33. Feasibility study of a Wearable Individual Dose Monitoring Apparatus: an innovative approach for molecular radiotherapy
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Camillocci, E. Solfaroli, primary, Collamati, F., additional, Faccini, R., additional, Iaccarino, G., additional, Terracciano, C. Mancini, additional, Mirabelli, R., additional, Nicolanti, F., additional, Pacilio, M., additional, Soriani, A., additional, and Morganti, S., additional
- Published
- 2021
- Full Text
- View/download PDF
34. Performance of the ToF detectors in the FOOT experiment
- Author
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Traini, G., Alexandrov, A., Alpat, B., Ambrosi, G., Argiro, S., Arteche, D. R., Bartosik, N., Battistoni, G., Belcari, N., Bellinzona, E., Biondi, S., Bisogni, M. G., Bruni, G., Camarlinghi, N., Carra, P., Cerello, P., Ciarrocchi, E., Clozza, A., Colombi, S., de Lellis, G., Del Guerra, A., de Simoni, M., Di Crescenzo, A., Donetti, M., Dong, Y., Durante, M., Emde, M., Faccini, R., Ferrero, V., Ferroni, F., Fiandrini, E., Finck, C., Fiorina, E., Fischetti, M., Francesconi, M., Franchini, M., Franciosini, G., Galati, G., Galli, L., Gentile, V., Giraudo, G., Hetzel, R., Iarocci, E., Ionica, M., Kanxheri, K., Kraan, A. C., Lante, V., Lauria, A., la Tessa, C., Lopez Torres, E., Massimi, C., Mattei, I., Marafini, M., Mengarelli, A., Mirabelli, R., Montesi, M. C., Morone, M. C., Morrocchi, M., Moggi, A., Muraro, S., Narici, L., Pastore, A., Pastrone, N., Patera, V., Pennazio, F., Placidi, P., Pullia, M., Raffaelli, F., Ramello, L., Ridolfi, R., Rosso, V., Rovituso, M., Sanelli, C., Sarti, A., Sartorelli, G., Sato, O., Scavarda, L., Savazzi, A., Schiavi, A., Schuy, C., Scifoni, E., Sciubba, A., Selvi, M., Servoli, L., Secher, A., Silvestre, G., Sitta, M., Spighi, R., Spiriti, E., Sportelli, G., Stahl, A., Tomassini, S., Tommasino, F., Valeri, T., Valle, S. M., Vanstalle, M., Villa, M., Weber, U., Zoccoli, A., Traini G., Alexandrov A., Alpat B., Ambrosi G., Argiro S., Arteche D.R., Bartosik N., Battistoni G., Belcari N., Bellinzona E., Biondi S., Bisogni M.G., Bruni G., Camarlinghi N., Carra P., Cerello P., Ciarrocchi E., Clozza A., Colombi S., de Lellis G., Del Guerra A., de Simoni M., Di Crescenzo A., Donetti M., Dong Y., Durante M., Emde M., Faccini R., Ferrero V., Ferroni F., Fiandrini E., Finck C., Fiorina E., Fischetti M., Francesconi M., Franchini M., Franciosini G., Galati G., Galli L., Gentile V., Giraudo G., Hetzel R., Iarocci E., Ionica M., Kanxheri K., Kraan A.C., Lante V., Lauria A., la Tessa C., Lopez Torres E., Massimi C., Mattei I., Marafini M., Mengarelli A., Mirabelli R., Montesi M.C., Morone M.C., Morrocchi M., Moggi A., Muraro S., Narici L., Pastore A., Pastrone N., Patera V., Pennazio F., Placidi P., Pullia M., Raffaelli F., Ramello L., Ridolfi R., Rosso V., Rovituso M., Sanelli C., Sarti A., Sartorelli G., Sato O., Scavarda L., Savazzi A., Schiavi A., Schuy C., Scifoni E., Sciubba A., Selvi M., Servoli L., Secher A., Silvestre G., Sitta M., Spighi R., Spiriti E., Sportelli G., Stahl A., Tomassini S., Tommasino F., Valeri T., Valle S.M., Vanstalle M., Villa M., Weber U., and Zoccoli A.
- Subjects
Particle Therapy ,Radio Protection Space ,Gantry Cranes ,Pencil Beams ,Fragmentation cross section, Particle Therapy, Radio Protection Space ,Fragmentation cross section ,Proton Therapy ,ddc:530 - Abstract
Fast Timing Applications for nuclear physics and medical imaging, FATA2019, Acireale, Italy, 3 Sep 2019 - 5 Sep 2019; Il nuovo cimento / C 43(1), 1-7 (2020). doi:10.1393/ncc/i2020-20016-5 special issue: "[FATA2019: FAst Timing Applications for nuclear physics and medical imaging, FATA2019, 2019-09-03 - 2019-09-05, Acireale, Italy]", Published by Italian Physical Soc., [S.l.]
- Published
- 2020
- Full Text
- View/download PDF
35. The prognostic relevance of HER2-positivity gain in metastatic breast cancer in the ChangeHER trial
- Author
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Pizzuti, L., Barba, M., Mazzotta, M., Krasniqi, E., Maugeri-Sacca, M., Gamucci, T., Berardi, R., Livi, L., Ficorella, C., Natoli, C., Cortesi, E., Generali, D., La Verde, N., Cassano, A., Bria, Emilio, Moscetti, L., Michelotti, A., Adamo, V., Zamagni, C., Tonini, G., Sergi, D., Marinelli, D., Paoletti, G., Tomao, S., Botticelli, A., Marchetti, P., Tinari, N., Grassadonia, A., Valerio, M. R., Mirabelli, R., Fabbri, M. A., D'Ostilio, N., Veltri, E., Corsi, Domenico Cristiano, Garrone, O., Paris, Ida, Sarobba, G., Meattini, I., Pistelli, M., Giotta, F., Lorusso, V., Garufi, C., Russo, A., Cazzaniga, M., Del Medico, P., Roselli, M., Vaccaro, A., Perracchio, L., di Benedetto, A., Daralioti, T., Sperduti, I., De Maria Marchiano, Ruggero, Di Leo, A., Sanguineti, G., Ciliberto, G., Vici, P., Bria E. (ORCID:0000-0002-2333-704X), Corsi D., Paris I., De Maria R. (ORCID:0000-0003-2255-0583), Pizzuti, L., Barba, M., Mazzotta, M., Krasniqi, E., Maugeri-Sacca, M., Gamucci, T., Berardi, R., Livi, L., Ficorella, C., Natoli, C., Cortesi, E., Generali, D., La Verde, N., Cassano, A., Bria, Emilio, Moscetti, L., Michelotti, A., Adamo, V., Zamagni, C., Tonini, G., Sergi, D., Marinelli, D., Paoletti, G., Tomao, S., Botticelli, A., Marchetti, P., Tinari, N., Grassadonia, A., Valerio, M. R., Mirabelli, R., Fabbri, M. A., D'Ostilio, N., Veltri, E., Corsi, Domenico Cristiano, Garrone, O., Paris, Ida, Sarobba, G., Meattini, I., Pistelli, M., Giotta, F., Lorusso, V., Garufi, C., Russo, A., Cazzaniga, M., Del Medico, P., Roselli, M., Vaccaro, A., Perracchio, L., di Benedetto, A., Daralioti, T., Sperduti, I., De Maria Marchiano, Ruggero, Di Leo, A., Sanguineti, G., Ciliberto, G., Vici, P., Bria E. (ORCID:0000-0002-2333-704X), Corsi D., Paris I., and De Maria R. (ORCID:0000-0003-2255-0583)
- Abstract
In metastatic breast cancer (mBC), the change of human epidermal growth factor receptor 2 (HER2) status between primary and metastatic lesions is widely recognized, however clinical implications are unknown. Our study address the question if relevant differences exist between subjects who preserve the HER2 status and those who gain the HER2 positivity when relapsed. Data of patients affected by HER2-positive mBC, treated with pertuzumab and/or trastuzumab-emtansine (T-DM1) in a real-world setting at 45 Italian cancer centers were retrospectively collected and analyzed. From 2003 to 2017, 491 HER2‐positive mBC patients were included. Of these, 102 (20.7%) had been initially diagnosed as HER2-negative early BC. Estrogen and/or progesterone receptor were more expressed in patients with HER2-discordance compared to patients with HER2-concordant status (p < 0.0001 and p = 0.006, respectively). HER2-discordant tumors were characterized also by a lower rate of brain metastases (p = 0.01) and a longer disease free interval (p < 0.0001). Median overall survival was longer, although not statistically significant, in the subgroup of patients with HER2-discordant cancer with respect to patients with HER2-concordant status (140 vs 78 months, p = 0.07). Our findings suggest that patients with HER2-positive mBC with discordant HER2 status in early BC may have different clinical, biological and prognostic behavior compared to HER2-concordant patients.
- Published
- 2021
36. Track reconstruction in the FOOT experiment
- Author
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Franchini, M., Ambrosi, G., Argirò, S., Battistoni, G., Belcari, N., Biondi, S., Bisogni, M.G., Bruni, G., Camarlinghi, N., Carra, P., Ciarrocchi, E., Cerello, P., Clozza, A., Colombi, S., De Lellis, G., Del Guerra, A., De Simoni, M., Di Crescenzo, A., Donetti, M., Dong, Y., Durante, M., Embriaco, A., Emde, M., Faccini, R., Ferrero, V., Ferroni, F., Fiandrini, E., Finck, C., Fiorina, E., Fischetti, M., Francesconi, M., Galli, L., Garbini, M., Gentile, V., Giraudo, G., Hetzel, R., Hild, S., Iarocci, E., Ionica, M., Kanxheri, K., Kraan, A.C., Lante, V., Lauria, A., Le Tessa, C., Lopez Torres, E., Marafini, M., Mattei, I., Mengarelli, A., Mirabelli, R., Montesi, M.C., Morone, M.C., Morrocchi, M., Muraro, S., Narici, L., Pastore, A., Pastrone, N., Patera, V., Pennazio, F., Placidi, P., Pullia, M., Ramello, L., Ridolfi, R., Rosso, V., Rovituso, M., Sanelli, C., Sarti, A., Sartorelli, G., Sato, O., Savazzi, S., Schiavi, A., Schuy, C., Scifoni, E., Sciubba, A., Selvi, M., Servoli, L., Silvestre, G., Sitta, M., Spighi, R., Spiriti, E., Sportelli, G., Stahl, A., Tomassini, S., Tommasino, F., Traini, G., Valeri, T., Valle, S.M., Vanstalle, M., Villa, M., Weber, U., Zoccoli, A., Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Franchini, M, Ambrosi, G, Argiro, S, Battistoni, G, Belcari, N, Biondi, S, Bisogni, MG, Bruni, G, Camarlinghi, N, Carra, P, Ciarrocchi, E, Cerello, P, Clozza, A, Colombi, S, De Lellis, G, Del Guerra, A, De Simoni, M, Di Crescenzo, A, Donetti, M, Dong, Y, Durante, M, Embriaco, A, Emde, M, Faccini, R, Ferrero, V, Ferroni, F, Fiandrini, E, Finck, C, Fiorina, E, Fischetti, M, Francesconi, M, Galli, L, Garbini, M, Gentile, V, Giraudo, G, Hetzel, R, Hild, S, Iarocci, E, Ionica, M, Kanxheri, K, Kraan, AC, Lante, V, Lauria, A, La Tessa, C, Torres, EL, Marafini, M, Mattel, I, Mengarelli, A, Mirabelli, R, Montesi, MC, Morone, MC, Morrocchi, M, Muraro, S, Narici, L, Pastore, A, Pastrone, N, Patera, V, Pennazio, F, Placidi, P, Pullia, M, Ramello, L, Ridolfi, R, Rosso, V, Rovituso, M, Sanelli, C, Sarti, A, Sartorelli, G, Sato, O, Savazzi, S, Schiavi, A, Schuy, C, Scifoni, E, Sciubba, A, Selvi, M, Servoli, L, Silvestre, G, Sitta, M, Spighi, R, Spiriti, E, Sportelli, G, Stahl, A, Tomassini, S, Tommasino, F, Traini, G, Valeri, T, Valle, SM, Vanstalle, M, Villa, M, Weber, U, Zoccoli, A, and Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,Nuclear Experiment ,fragmentation, hadrotherapy, cross section - Abstract
International audience; The FOOT experiment is a fixed target experiment aiming for high precision (better than 5%) measurement of fragmentation cross section for hadrontherapy and space radioprotection purposes. Both target and projectile fragmentation are studied by using mainly proton, Carbon and Oxygen ion beams in both direct and inverse kinematic regime, alternatively. A good track reconstruction and momentum measurement is of fundamental importance for precise fragment identification and cross section measurement.
- Published
- 2019
- Full Text
- View/download PDF
37. Tumor-non-tumor discrimination by a β- detector for Radio Guided Surgery on ex-vivo neuroendocrine tumors samples
- Author
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Morganti, S., Bertani, E., Bocci, V., Colandrea, M., Collamati, F., Cremonesi, M., De Simoni, M., Ferrari, E., Fischetti, M., Funicelli, L., Grana, C. M., Mancini-Terracciano, C., Mirabelli, R., Papi, S., Pisa, E., Solfaroli-Camillocci, E., Traini, G., and Faccini, R.
- Subjects
RGS ,electrons ,tumor-non-tumor discrimination ,GEP NET - Published
- 2020
38. Impact of BMI on HER2+ metastatic breast cancer patients treated with pertuzumab and/or trastuzumab emtansine. Real-world evidence
- Author
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Krasniqi, E, Pizzuti, L, Barchiesi, G, Sergi, D, Carpano, S, Botti, C, Kayal, R, Sanguineti, G, Marchetti, P, Botticelli, A, Marinelli, D, Gamucci, T, Natoli, C, Grassadonia, A, Tinari, N, Tomao, S, Tonini, G, Santini, D, Michelotti, A, Mentuccia, L, Vaccaro, A, Magnolfi, E, Gelibter, A, Magri, V, Cortesi, E, D'Onofrio, L, Cassano, A, Cazzaniga, M, Moscetti, L, Fabbri, A, Scinto, A, Corsi, D, Carbognin, L, Bria, E, La Verde, N, Garufi, C, Di Stefano, P, Mirabelli, R, Veltri, E, Paris, I, Giotta, F, Lorusso, V, Landucci, E, Ficorella, C, Roselli, M, Adamo, V, Ricciardi, G, Russo, A, Valerio, M, Berardi, R, Pistelli, M, Cannita, K, Zamagni, C, Garrone, O, Baldini, E, Livi, L, Meattini, I, Del Medico, P, Generali, D, De Maria, R, Risi, E, Ciliberto, G, Villa, A, Sperduti, I, Mazzotta, M, Barba, M, Giordano, A, Vici, P, Krasniqi, Eriseld, Pizzuti, Laura, Barchiesi, Giacomo, Sergi, Domenico, Carpano, Silvia, Botti, Claudio, Kayal, Ramy, Sanguineti, Giuseppe, Marchetti, Paolo, Botticelli, Andrea, Marinelli, Daniele, Gamucci, Teresa, Natoli, Clara, Grassadonia, Antonino, Tinari, Nicola, Tomao, Silverio, Tonini, Giuseppe, Santini, Daniele, Michelotti, Aandrea, Mentuccia, Lucia, Vaccaro, Aangela, Magnolfi, Emanuela, Gelibter, Alain, Magri, Valentina, Cortesi, Enrico, D'Onofrio, Loretta, Cassano, Alessandra, Cazzaniga, Marina, Moscetti, Luca, Fabbri, Agnese, Scinto, Angelo Fedele, Corsi, Domenico, Carbognin, Luisa, Bria, Emilio, La Verde, Nicla, Garufi, Carlo, Di Stefano, Pia, Mirabelli, Rossana, Veltri, Enzo, Paris, Ida, Giotta, Francesco, Lorusso, Vito, Landucci, Elisa, Ficorella, Corrado, Roselli, Mario, Adamo, Vincenzo, Ricciardi, Giuseppina, Russo, Antonio, Valerio, Maria Rosaria, Berardi, Rossana, Pistelli, Mirco, Cannita, Katia, Zamagni, Claudio, Garrone, Ornella, Baldini, Editta, Livi, Lorenzo, Meattini, Icro, Del Medico, Pietro, Generali, Daniele, De Maria, Ruggero, Risi, Emanuela, Ciliberto, Gennaro, Villa, Alice, Sperduti, Isabella, Mazzotta, Marco, Barba, Maddalena, Giordano, Antonio, Vici, Patrizia, Krasniqi, E, Pizzuti, L, Barchiesi, G, Sergi, D, Carpano, S, Botti, C, Kayal, R, Sanguineti, G, Marchetti, P, Botticelli, A, Marinelli, D, Gamucci, T, Natoli, C, Grassadonia, A, Tinari, N, Tomao, S, Tonini, G, Santini, D, Michelotti, A, Mentuccia, L, Vaccaro, A, Magnolfi, E, Gelibter, A, Magri, V, Cortesi, E, D'Onofrio, L, Cassano, A, Cazzaniga, M, Moscetti, L, Fabbri, A, Scinto, A, Corsi, D, Carbognin, L, Bria, E, La Verde, N, Garufi, C, Di Stefano, P, Mirabelli, R, Veltri, E, Paris, I, Giotta, F, Lorusso, V, Landucci, E, Ficorella, C, Roselli, M, Adamo, V, Ricciardi, G, Russo, A, Valerio, M, Berardi, R, Pistelli, M, Cannita, K, Zamagni, C, Garrone, O, Baldini, E, Livi, L, Meattini, I, Del Medico, P, Generali, D, De Maria, R, Risi, E, Ciliberto, G, Villa, A, Sperduti, I, Mazzotta, M, Barba, M, Giordano, A, Vici, P, Krasniqi, Eriseld, Pizzuti, Laura, Barchiesi, Giacomo, Sergi, Domenico, Carpano, Silvia, Botti, Claudio, Kayal, Ramy, Sanguineti, Giuseppe, Marchetti, Paolo, Botticelli, Andrea, Marinelli, Daniele, Gamucci, Teresa, Natoli, Clara, Grassadonia, Antonino, Tinari, Nicola, Tomao, Silverio, Tonini, Giuseppe, Santini, Daniele, Michelotti, Aandrea, Mentuccia, Lucia, Vaccaro, Aangela, Magnolfi, Emanuela, Gelibter, Alain, Magri, Valentina, Cortesi, Enrico, D'Onofrio, Loretta, Cassano, Alessandra, Cazzaniga, Marina, Moscetti, Luca, Fabbri, Agnese, Scinto, Angelo Fedele, Corsi, Domenico, Carbognin, Luisa, Bria, Emilio, La Verde, Nicla, Garufi, Carlo, Di Stefano, Pia, Mirabelli, Rossana, Veltri, Enzo, Paris, Ida, Giotta, Francesco, Lorusso, Vito, Landucci, Elisa, Ficorella, Corrado, Roselli, Mario, Adamo, Vincenzo, Ricciardi, Giuseppina, Russo, Antonio, Valerio, Maria Rosaria, Berardi, Rossana, Pistelli, Mirco, Cannita, Katia, Zamagni, Claudio, Garrone, Ornella, Baldini, Editta, Livi, Lorenzo, Meattini, Icro, Del Medico, Pietro, Generali, Daniele, De Maria, Ruggero, Risi, Emanuela, Ciliberto, Gennaro, Villa, Alice, Sperduti, Isabella, Mazzotta, Marco, Barba, Maddalena, Giordano, Antonio, and Vici, Patrizia
- Abstract
Body mass index (BMI) is a main indicator of obesity and its association with breast cancer is well established. However, little is known in the metastatic setting, especially in HER2-positive patients. We assessed the influence of BMI on clinical outcomes of patients treated with pertuzumab and/or trastuzumab emtansine (T-DM1) for HER2+ metastatic breast cancer (mBC). BMI was addressed as a categorical variable, being classified on the basis of the following ranges, that is, 18.5–24.9, 25–29.9, and 30.0–34.9, namely, normal weight, overweight, and Class I obesity. The outcomes chosen were progression-free survival to first-line chemotherapy (PFS1) and overall survival (OS). Overall (N = 709), no impact of BMI was observed on PFS1 (p =.15), while BMI ≥ 30 was associated with worse OS (p =.003). In subjects who progressed to first line (N = 575), analyzing data across PFS1 quartiles and strata of disease burden, BMI predicted lower PFS1 in patients within the I PFS1 quartile and with the lowest disease burden (p =.001). Univariate analysis showed a detrimental effect of BMI ≥ 30 on OS for women within the I PFS1 quartile (p =.03). Results were confirmed in multivariate analysis. According to PFS1 quartiles a higher percentage of patients with high BMI and low disease burden progressed within 6 months of therapy. The effect of BMI on prognosis was also confirmed in multivariate analysis of OS for overall population. In our cohort, a BMI ≥ 30 correlated with worse OS in patients with HER2+ mBC who received pertuzumab and/or T-DM1 but had no impact on PFS to first line. BMI predicted worse I PFS1 quartile.
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- 2020
39. Loss of HER2 and decreased T-DM1 efficacy in HER2 positive advanced breast cancer treated with dual HER2 blockade: the SePHER Study
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Bon, G., Pizzuti, L., Laquintana, V., Loria, R., Porru, M., Marchio, C., Krasniqi, E., Barba, M., Maugeri-Sacca, M., Gamucci, T., Berardi, R., Livi, L., Ficorella, C., Natoli, C., Cortesi, E., Generali, D., La Verde, N., Cassano, Alessandra, Bria, Emilio, Moscetti, L., Michelotti, A., Adamo, V., Zamagni, C., Tonini, G., Barchiesi, G., Mazzotta, M., Marinelli, D., Tomao, S., Marchetti, P., Valerio, M. R., Mirabelli, R., Russo, A., Fabbri, M. A., D'Ostilio, N., Veltri, E., Corsi, D., Garrone, O., Paris, I., Sarobba, G., Giotta, F., Garufi, C., Cazzaniga, M., Del Medico, P., Roselli, M., Sanguineti, G., Sperduti, I., Sapino, A., De Maria Marchiano, Ruggero, Leonetti, C., Di Leo, A., Ciliberto, G., Falcioni, R., Vici, P., Cassano A. (ORCID:0000-0002-3311-7163), Bria E. (ORCID:0000-0002-2333-704X), De Maria R. (ORCID:0000-0003-2255-0583), Bon, G., Pizzuti, L., Laquintana, V., Loria, R., Porru, M., Marchio, C., Krasniqi, E., Barba, M., Maugeri-Sacca, M., Gamucci, T., Berardi, R., Livi, L., Ficorella, C., Natoli, C., Cortesi, E., Generali, D., La Verde, N., Cassano, Alessandra, Bria, Emilio, Moscetti, L., Michelotti, A., Adamo, V., Zamagni, C., Tonini, G., Barchiesi, G., Mazzotta, M., Marinelli, D., Tomao, S., Marchetti, P., Valerio, M. R., Mirabelli, R., Russo, A., Fabbri, M. A., D'Ostilio, N., Veltri, E., Corsi, D., Garrone, O., Paris, I., Sarobba, G., Giotta, F., Garufi, C., Cazzaniga, M., Del Medico, P., Roselli, M., Sanguineti, G., Sperduti, I., Sapino, A., De Maria Marchiano, Ruggero, Leonetti, C., Di Leo, A., Ciliberto, G., Falcioni, R., Vici, P., Cassano A. (ORCID:0000-0002-3311-7163), Bria E. (ORCID:0000-0002-2333-704X), and De Maria R. (ORCID:0000-0003-2255-0583)
- Abstract
Background: HER2-targeting agents have dramatically changed the therapeutic landscape of HER2+ advanced breast cancer (ABC). Within a short time frame, the rapid introduction of new therapeutics has led to the approval of pertuzumab combined with trastuzumab and a taxane in first-line, and trastuzumab emtansine (T-DM1) in second-line. Thereby, evidence of T-DM1 efficacy following trastuzumab/pertuzumab combination is limited, with data from some retrospective reports suggesting lower activity. The purpose of the present study is to investigate T-DM1 efficacy in pertuzumab-pretreated and pertuzumab naïve HER2 positive ABC patients. We also aimed to provide evidence on the exposure to different drugs sequences including pertuzumab and T-DM1 in HER2 positive cell lines. Methods: The biology of HER2 was investigated in vitro through sequential exposure of resistant HER2 + breast cancer cell lines to trastuzumab, pertuzumab, and their combination. In vitro experiments were paralleled by the analysis of data from 555 HER2 + ABC patients treated with T-DM1 and evaluation of T-DM1 efficacy in the 371 patients who received it in second line. Survival estimates were graphically displayed in Kaplan Meier curves, compared by log rank test and, when possibile, confirmed in multivariate models. Results: We herein show evidence of lower activity of T-DM1 in two HER2+ breast cancer cell lines resistant to trastuzumab+pertuzumab, as compared to trastuzumab-resistant cells. Lower T-DM1 efficacy was associated with a marked reduction of HER2 expression on the cell membrane and its nuclear translocation. HER2 downregulation at the membrane level was confirmed in biopsies of four trastuzumab/pertuzumab-pretreated patients. Among the 371 patients treated with second-line T-DM1, median overall survival (mOS) from diagnosis of advanced disease and median progression-free survival to second-line treatment (mPFS2) were 52 and 6 months in 177 patients who received trastuzumab/pertuzumab in f
- Published
- 2020
40. Impact of BMI on HER2+ metastatic breast cancer patients treated with pertuzumab and/or trastuzumab emtansine. Real-world evidence
- Author
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Krasniqi, E., Pizzuti, L., Barchiesi, G., Sergi, D., Carpano, S., Botti, C., Kayal, R., Sanguineti, G., Marchetti, P., Botticelli, A., Marinelli, D., Gamucci, T., Natoli, C., Grassadonia, A., Tinari, N., Tomao, S., Tonini, Gerolamo, Santini, D., Michelotti, A., Mentuccia, L., Vaccaro, Ascanio Giuseppe, Magnolfi, E., Gelibter, A., Magri, V., Cortesi, E., D'Onofrio, L., Cassano, A., Cazzaniga, M., Moscetti, L., Fabbri, A., Scinto, A. F., Corsi, Domenico Cristiano, Carbognin, L., Bria, Emilio, La Verde, N., Garufi, C., Di Stefano, P., Mirabelli, R., Veltri, E., Paris, Ida, Giotta, F., Lorusso, V., Landucci, E., Ficorella, C., Roselli, M., Adamo, V., Ricciardi, Walter, Russo, A., Valerio, M. R., Berardi, R., Pistelli, M., Cannita, K., Zamagni, C., Garrone, O., Baldini, E., Livi, L., Meattini, I., Del Medico, P., Generali, Daniele, De Maria Marchiano, Ruggero, Risi, E., Ciliberto, G., Villa, Angela Ida, Sperduti, I., Mazzotta, M., Barba, M., Giordano, Alessandro, Vici, P., Tonini G., Vaccaro A., Corsi D., Bria E. (ORCID:0000-0002-2333-704X), Paris I., Ricciardi G. (ORCID:0000-0002-5655-688X), Generali D. (ORCID:0000-0003-2480-3855), De Maria R. (ORCID:0000-0003-2255-0583), Villa A. (ORCID:0000-0003-0679-334X), Giordano A. (ORCID:0000-0002-6978-0880), Krasniqi, E., Pizzuti, L., Barchiesi, G., Sergi, D., Carpano, S., Botti, C., Kayal, R., Sanguineti, G., Marchetti, P., Botticelli, A., Marinelli, D., Gamucci, T., Natoli, C., Grassadonia, A., Tinari, N., Tomao, S., Tonini, Gerolamo, Santini, D., Michelotti, A., Mentuccia, L., Vaccaro, Ascanio Giuseppe, Magnolfi, E., Gelibter, A., Magri, V., Cortesi, E., D'Onofrio, L., Cassano, A., Cazzaniga, M., Moscetti, L., Fabbri, A., Scinto, A. F., Corsi, Domenico Cristiano, Carbognin, L., Bria, Emilio, La Verde, N., Garufi, C., Di Stefano, P., Mirabelli, R., Veltri, E., Paris, Ida, Giotta, F., Lorusso, V., Landucci, E., Ficorella, C., Roselli, M., Adamo, V., Ricciardi, Walter, Russo, A., Valerio, M. R., Berardi, R., Pistelli, M., Cannita, K., Zamagni, C., Garrone, O., Baldini, E., Livi, L., Meattini, I., Del Medico, P., Generali, Daniele, De Maria Marchiano, Ruggero, Risi, E., Ciliberto, G., Villa, Angela Ida, Sperduti, I., Mazzotta, M., Barba, M., Giordano, Alessandro, Vici, P., Tonini G., Vaccaro A., Corsi D., Bria E. (ORCID:0000-0002-2333-704X), Paris I., Ricciardi G. (ORCID:0000-0002-5655-688X), Generali D. (ORCID:0000-0003-2480-3855), De Maria R. (ORCID:0000-0003-2255-0583), Villa A. (ORCID:0000-0003-0679-334X), and Giordano A. (ORCID:0000-0002-6978-0880)
- Abstract
Body mass index (BMI) is a main indicator of obesity and its association with breast cancer is well established. However, little is known in the metastatic setting, especially in HER2-positive patients. We assessed the influence of BMI on clinical outcomes of patients treated with pertuzumab and/or trastuzumab emtansine (T-DM1) for HER2+ metastatic breast cancer (mBC). BMI was addressed as a categorical variable, being classified on the basis of the following ranges, that is, 18.5–24.9, 25–29.9, and 30.0–34.9, namely, normal weight, overweight, and Class I obesity. The outcomes chosen were progression-free survival to first-line chemotherapy (PFS1) and overall survival (OS). Overall (N = 709), no impact of BMI was observed on PFS1 (p =.15), while BMI ≥ 30 was associated with worse OS (p =.003). In subjects who progressed to first line (N = 575), analyzing data across PFS1 quartiles and strata of disease burden, BMI predicted lower PFS1 in patients within the I PFS1 quartile and with the lowest disease burden (p =.001). Univariate analysis showed a detrimental effect of BMI ≥ 30 on OS for women within the I PFS1 quartile (p =.03). Results were confirmed in multivariate analysis. According to PFS1 quartiles a higher percentage of patients with high BMI and low disease burden progressed within 6 months of therapy. The effect of BMI on prognosis was also confirmed in multivariate analysis of OS for overall population. In our cohort, a BMI ≥ 30 correlated with worse OS in patients with HER2+ mBC who received pertuzumab and/or T-DM1 but had no impact on PFS to first line. BMI predicted worse I PFS1 quartile.
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- 2020
41. Distinct HR expression patterns significantly affect the clinical behavior of metastatic HER2+ breast cancer and degree of benefit from novel anti-HER2 agents in the real world setting
- Author
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Pizzuti, L., Krasniqi, E., Barchiesi, G., Della Giulia, M., Izzo, F., Sanguineti, G., Marchetti, P., Mazzotta, M., Giusti, R., Botticelli, A., Gamucci, T., Natoli, C., Grassadonia, A., Tinari, N., Iezzi, L., Tomao, S., Tomao, F., Tonini, G., Santini, D., Astone, Antonio, Michelotti, A., De Angelis, C., Mentuccia, L., Vaccaro, A., Magnolfi, E., Gelibter, A., Magri, V., Cortesi, E., D'Onofrio, L., Cassano, A., Rossi, E., Cazzaniga, M., Moscetti, L., Omarini, C., Piacentini, F., Fabbri, M. A., Scinto, A. F., Corsi, D., Carbognin, L., Bria, Emilio, La Verde, N., Samaritani, R., Garufi, C., Barni, S., Mirabelli, R., Sarmiento, R., Veltri, E. M., D'Auria, G., Paris, I., Giotta, F., Lorusso, V., Cardillo, F., Landucci, E., Mauri, M., Ficorella, C., Roselli, M., Adamo, V., Ricciardi, G. R. R., Russo, A., Berardi, R., Pistelli, M., Fiorio, E., Cannita, K., Sini, V., D'Ostilio, N., Foglietta, J., Greco, F., Zamagni, C., Garrone, O., Di Cocco, B., Baldini, E., Livi, L., Desideri, I., Meattini, I., Sarobba, G., Del Medico, P., De Tursi, M., Generali, D., De Maria Marchiano, Ruggero, Risi, E., Ciliberto, G., Sperduti, I., Villa, A., Barba, M., Di Leo, A., Vici, P., Astone A. (ORCID:0000-0001-9572-309X), Bria E. (ORCID:0000-0002-2333-704X), De Maria R. (ORCID:0000-0003-2255-0583), Pizzuti, L., Krasniqi, E., Barchiesi, G., Della Giulia, M., Izzo, F., Sanguineti, G., Marchetti, P., Mazzotta, M., Giusti, R., Botticelli, A., Gamucci, T., Natoli, C., Grassadonia, A., Tinari, N., Iezzi, L., Tomao, S., Tomao, F., Tonini, G., Santini, D., Astone, Antonio, Michelotti, A., De Angelis, C., Mentuccia, L., Vaccaro, A., Magnolfi, E., Gelibter, A., Magri, V., Cortesi, E., D'Onofrio, L., Cassano, A., Rossi, E., Cazzaniga, M., Moscetti, L., Omarini, C., Piacentini, F., Fabbri, M. A., Scinto, A. F., Corsi, D., Carbognin, L., Bria, Emilio, La Verde, N., Samaritani, R., Garufi, C., Barni, S., Mirabelli, R., Sarmiento, R., Veltri, E. M., D'Auria, G., Paris, I., Giotta, F., Lorusso, V., Cardillo, F., Landucci, E., Mauri, M., Ficorella, C., Roselli, M., Adamo, V., Ricciardi, G. R. R., Russo, A., Berardi, R., Pistelli, M., Fiorio, E., Cannita, K., Sini, V., D'Ostilio, N., Foglietta, J., Greco, F., Zamagni, C., Garrone, O., Di Cocco, B., Baldini, E., Livi, L., Desideri, I., Meattini, I., Sarobba, G., Del Medico, P., De Tursi, M., Generali, D., De Maria Marchiano, Ruggero, Risi, E., Ciliberto, G., Sperduti, I., Villa, A., Barba, M., Di Leo, A., Vici, P., Astone A. (ORCID:0000-0001-9572-309X), Bria E. (ORCID:0000-0002-2333-704X), and De Maria R. (ORCID:0000-0003-2255-0583)
- Abstract
We analyzed data from 738 HER2-positive metastatic breast cancer (mbc) patients treated with pertuzumab-based regimens and/or T-DM1 at 45 Italian centers. Outcomes were explored in relation to tumor subtype assessed by immunohistochemistry (IHC). The median progression-free survival at first-line (mPFS1) was 12 months. Pertuzumab as first-line conferred longer mPFS1 compared to other first-line treatments (16 vs. 9 months, p = 0.0001), regardless of IHC subtype. Median PFS in second-line (mPFS2) was 7 months, with no difference by IHC subtype, but it was more favorable with T-DM1 compared to other agents (7 vs. 6 months, p = 0.03). There was no PFS2 gain in patients with tumors expressing both hormonal receptors (HRs; p = 0.17), while a trend emerged for tumors with one HR (p = 0.05). Conversely, PFS2 gain was significant in HRs-negative tumors (p = 0.04). Median overall survival (mOS) was 74 months, with no significant differences by IHC subtypes. Survival rates at 2 and 3 years in patients treated with T-DM1 in second-line after pertuzumab were significantly lower compared to pertuzumab-naïve patients (p = 0.01). When analyzed by IHC subtype, the outcome was confirmed if both HRs or no HRs were expressed (p = 0.02 and p = 0.006, respectively). Our results confirm that HRs expression impacts the clinical behavior and novel treatment-related outcomes of HER2-positive tumors when treatment sequences are considered. Moreover, multivariate analysis showed that HRs expression had no effect on PFS and OS. Further studies are warranted to confirm our findings and clarify the interplay between HER2 and estrogen receptor pathways in HER2-positive (mbc) patients.
- Published
- 2020
42. Characterisation of a [formula omitted] detector on positron emitters for medical applications
- Author
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Collamati, F., Moretti, R., Alunni-Solestizi, L., Bocci, V., Cartoni, A., Collarino, A., De Simoni, M., Faccini, R., Fischetti, M., Giordano, A., Maccora, D., Mancini-Terracciano, C., Mirabelli, R., Scotognella, T., Solfaroli-Camillocci, E., Traini, G., and Morganti, S.
- Published
- 2019
- Full Text
- View/download PDF
43. Inter-fractional monitoring of $$^{12}$$C ions treatments: results from a clinical trial at the CNAO facility
- Author
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Fischetti, M., primary, Baroni, G., additional, Battistoni, G., additional, Bisogni, G., additional, Cerello, P., additional, Ciocca, M., additional, De Maria, P., additional, De Simoni, M., additional, Di Lullo, B., additional, Donetti, M., additional, Dong, Y., additional, Embriaco, A., additional, Ferrero, V., additional, Fiorina, E., additional, Franciosini, G., additional, Galante, F., additional, Kraan, A., additional, Luongo, C., additional, Magi, M., additional, Mancini-Terracciano, C., additional, Marafini, M., additional, Malekzadeh, E., additional, Mattei, I., additional, Mazzoni, E., additional, Mirabelli, R., additional, Mirandola, A., additional, Morrocchi, M., additional, Muraro, S., additional, Patera, V., additional, Pennazio, F., additional, Schiavi, A., additional, Sciubba, A., additional, Solfaroli Camillocci, E., additional, Sportelli, G., additional, Tampellini, S., additional, Toppi, M., additional, Traini, G., additional, Valle, S. M., additional, Vischioni, B., additional, Vitolo, V., additional, and Sarti, A., additional
- Published
- 2020
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44. Stability and efficiency of a CMOS sensor as detector of low energy β and γ particles
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Collamati, F., primary, Amoruso, R., additional, Servoli, L., additional, Solestizi, L. Alunni, additional, Biasini, M., additional, Bocci, V., additional, Campeggi, C., additional, Maria, P. De, additional, Simoni, M. De, additional, Fischetti, M., additional, Franciosini, G., additional, Kanxheri, K., additional, Terracciano, C. Mancini, additional, Meddi, F., additional, Ionica, M. Movileanu, additional, Morganti, S., additional, Mirabelli, R., additional, Camillocci, E. Solfaroli, additional, Tóth, Á., additional, and Faccini, R., additional
- Published
- 2020
- Full Text
- View/download PDF
45. Feasibility study on the use of CMOS sensors as detectors in radioguided surgery withβ−- emitters
- Author
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Alunni Solestizi, L., primary, Amoruso, R., additional, Biasini, M., additional, Bocci, V., additional, Campeggi, C., additional, Capotosti, A., additional, Collamati, F., additional, Faccini, R., additional, Kanxheri, K., additional, Mancini Terracciano, C., additional, Mantini, S., additional, Marafini, M., additional, Meddi, F., additional, Movileanu Ionica, M., additional, Morganti, S., additional, Mirabelli, R., additional, Placidi, P., additional, Scorzoni, A., additional, Camillocci, E. Solfaroli, additional, and Servoli, L., additional
- Published
- 2020
- Full Text
- View/download PDF
46. FRED: a fast Monte Carlo code on GPU for quality control in Particle Therapy
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Simoni, M De, primary, Fischetti, M, additional, Gioscio, E, additional, Marafini, M, additional, Mirabelli, R, additional, Patera, V, additional, Sarti, A, additional, Schiavi, A, additional, Sciubba, A, additional, and Traini, G, additional
- Published
- 2020
- Full Text
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47. Tumor-non-tumor discrimination by aβ-detector for Radio Guided Surgery on ex-vivo neuroendocrine tumors samples
- Author
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Morganti, S., primary, Bertani, E., additional, Bocci, V., additional, Colandrea, M., additional, Collamati, F., additional, Cremonesi, M., additional, De Simoni, M., additional, Ferrari, E., additional, Fischetti, M., additional, Funicelli, L., additional, Grana, C.M., additional, Mancini-Terracciano, C., additional, Mirabelli, R., additional, Papi, S., additional, Pisa, E., additional, Solfaroli-Camillocci, E., additional, Traini, G., additional, and Faccini, R., additional
- Published
- 2020
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48. Measurement of 12C Fragmentation Cross Sections on C, O, and H in the Energy Range of Interest for Particle Therapy Applications
- Author
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Mattei, I., primary, Alexandrov, A., additional, Alunni Solestizi, L., additional, Ambrosi, G., additional, Argiro, S., additional, Bartosik, N., additional, Battistoni, G., additional, Belcari, N., additional, Biondi, S., additional, Bisogni, M. G., additional, Bruni, G., additional, Camarlinghi, N., additional, Carra, P., additional, Catanzani, E., additional, Ciarrocchi, E., additional, Cerello, P., additional, Clozza, A., additional, Colombi, S., additional, De Lellis, G., additional, Del Guerra, A., additional, De Simoni, M., additional, Di Crescenzo, A., additional, Donetti, M., additional, Dong, Y., additional, Durante, M., additional, Embriaco, A., additional, Emde, M., additional, Faccini, R., additional, Ferrero, V., additional, Ferroni, F., additional, Fiandrini, E., additional, Finck, C., additional, Fiorina, E., additional, Fischetti, M., additional, Francesconi, M., additional, Franchini, M., additional, Galli, L., additional, Gentile, V., additional, Hetzel, R., additional, Hild, S., additional, Iarocci, E., additional, Ionica, M., additional, Kanxheri, K., additional, Kraan, A. C., additional, Lante, V., additional, Lauria, A., additional, La Tessa, C., additional, Lopez Torres, E., additional, Massimi, C., additional, Marafini, M., additional, Mengarelli, A., additional, Mirabelli, R., additional, Montesi, M. C., additional, Morone, M. C., additional, Morrocchi, M., additional, Muraro, S., additional, Narici, L., additional, Pastore, A., additional, Pastrone, N., additional, Patera, V., additional, Pennazio, F., additional, Placidi, P., additional, Pullia, M., additional, Ramello, L., additional, Ridolfi, R., additional, Rosso, V., additional, Rovituso, M., additional, Sanelli, C., additional, Sartorelli, G., additional, Sato, O., additional, Savazzi, S., additional, Scavarda, L., additional, Schiavi, A., additional, Schuy, C., additional, Scifoni, E., additional, Sciubba, A., additional, Secher, A., additional, Selvi, M., additional, Servoli, L., additional, Silvestre, G., additional, Sitta, M., additional, Spighi, R., additional, Spiriti, E., additional, Sportelli, G., additional, Stahl, A., additional, Tomassini, S., additional, Tommasino, F., additional, Traini, G., additional, Toppi, M., additional, Valeri, T., additional, Valle, S. M., additional, Vanstalle, M., additional, Villa, M., additional, Weber, U., additional, Zoccoli, A., additional, and Sarti, A., additional
- Published
- 2020
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49. FOOT: FragmentatiOn Of Target Experiment
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Spighi, R., Alexandrov, A., Alpat, B., Ambrosi, G., Argirò, S., Battistoni, G., Belcari, N., Biondi, S., Bisogni, M.G., Bruni, G., Camarlinghi, N., Carra, P., Ciarrocchi, E., Cerello, P., Clozza, A., Colombi, S., Lellis, G.De, Guerra, A.Del, Simoni, M.De, Crescenzo, A.Di, Donetti, M., Dong, Y., Durante, M., Embriaco, A., Emde, M., Faccini, R., Ferrero, V., Ferroni, F., Fiandrini, E., Finck, C., Fiorina, E., Fischetti, M., Francesconi, M., Franchini, M., Galli, L., Garbini, M., Gentile, V., Giraudo, G., Hetzel, R., Hild, S., Iarocci, E., Ionica, M., Kanxheri, K., Kraan, A.C., Lante, V., Lauria, A., Tessa, C.La, Torres, E.Lopez, Marafini, M., Mattei, I., Mengarelli, A., Mirabelli, R., Montesi, M.C., Morone, M.C., Morrocchi, M., Muraro, S., Narici, L., Pastore, A., Pastrone, N., Patera, V., Pennazio, F., Placidi, P., Pullia, M., Ramello, L., Ridolfi, R., Rosso, V., Rovituso, M., Sanelli, C., Sarti, A., Sartorelli, G., Sato, O., Savazzi, S., Schiavi, A., Schuy, C., Scifoni, E., Sciubba, A., Selvi, M., Servoli, L., Silvestre, G., Sitta, M., Spiriti, E., Sportelli, G., Stahl, A., Tomassini, S., Tommasino, F., Traini, G., Valeri, T., Valle, S.M., Vanstalle, M., Villa, M., Weber, U., Zoccoli, A., Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Spighi, R, Alexandrov, A, Alpat, B, Ambrosi, G, Argiro, S, Battistoni, G, Belcari, N, Biondi, S, Bisogni, MG, Bruni, G, Camarlinghi, N, Carra, P, Ciarrocchi, E, Cerello, P, Clozza, A, Colombi, S, De Lellis, G, Del Guerra, A, De Simoni, M, Di Crescenzo, A, Donetti, M, Dong, Y, Durante, M, Embriaco, A, Emde, M, Faccini, R, Ferrero, V, Ferroni, F, Fiandrini, E, Finck, C, Fiorina, E, Fischetti, M, Francesconi, M, Franchini, M, Galli, L, Garbini, M, Gentile, V, Giraudo, G, Hetzel, R, Hild, S, Iarocci, E, Ionica, M, Kanxheri, K, Kraan, AC, Lante, V, Lauria, A, La Tessa, C, Torres, EL, Marafini, M, Mattei, I, Mengarelli, A, Mirabelli, R, Montesi, MC, Morone, MC, Morrocchi, M, Muraro, S, Narici, L, Pastore, A, Pastrone, N, Patera, V, Pennazio, F, Placidi, P, Pullia, M, Ramello, L, Ridolfi, R, Rosso, V, Rovituso, M, Sanelli, C, Sarti, A, Sartorelli, G, Sato, O, Savazzi, S, Schiavi, A, Schuy, C, Scifoni, E, Sciubba, A, Selvi, M, Servoli, L, Silvestre, G, Sitta, M, Spiriti, E, Sportelli, G, Stahl, A, Tomassini, S, Tommasino, F, Traini, G, Valeri, T, Valle, SM, Vanstalle, M, Villa, M, Weber, U, Zoccoli, A, and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Physics::Accelerator Physics ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,Nuclear Experiment ,fragmentation, foot, hadrontherapy, cross section - Abstract
International audience; The main goal of the FOOT (FragmentatiOn Of Target) experiment is the measurement of the differential cross sections as a function of energy and direction of the produced fragments in the nuclear interaction between a ion beam (proton, helium, carbon, ...) and different targets (proton, carbon, oxygen, ...). Depending on the beam energy, the purpose of the measurements is twofold: in the [150-400] MeV/u range, the data will be used to evaluate the side effects of the nuclear fragmentation in the hadrontherapy treatment, while in the [700-1000] MeV/u range it will be used to optimize the shielding of spaceships for long term space missions. The experiment has been funded by the INFN since September 2017 and it is currently in the construction phase. An overview of the detector, of the results obtained in several beam tests and of the expected performances will be presented.
- Published
- 2018
50. The β - radio-guided surgery: Method to estimate the minimum injectable activity from ex-vivo test
- Author
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Russomando, A., Schiariti, M., Bocci, V., Colandrea, M., Collamati, F., Cremonesi, M., Ferrari, M. E., Ferroli, P., Ghielmetti, F., Ghisini, R., Grana, C. M., Mancini Terracciano, C., Marafini, M., Mirabelli, R., Morganti, S., Papi, S., Patanè, M., Pedroli, G., Pollo, B., Solfaroli Camillocci, E., Traini, G., and Faccini, R.
- Subjects
Brain tumours ,Biophysics ,Radio-guided-surgery ,Octreotide ,Radiation Dosage ,β - decays ,Injections ,Beta Particles ,Physics and Astronomy (all) ,Computer-Assisted ,Occupational Exposure ,Positron-Emission Tomography ,Nuclear Medicine and Imaging ,Humans ,Surgery ,Yttrium Radioisotopes ,Intraoperative imaging ,Meningioma ,Radiology ,Surgery, Computer-Assisted ,Radiology, Nuclear Medicine and Imaging - Published
- 2019
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