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5 results on '"Mirabelle S.H. Ho"'

2. Contributors

Author

K.I. Agladze, Ibrahim Akin, Michail A. Alterman, Abdolreza Ardeshirylajimi, Alessia Bertero, Rahulkumar Bhoi, Natacha Breuls, Anne Bush, Francesca Caloni, Ivan Carcamo-Orive, Zhifen Chen, Teresa Coccini, Massimo Conese, Chad A. Cowan, Nathan James Cunningham, Ibrahim El-Battrawy, Benjamin S. Freedman, Andrée Gauthier-Fisher, Melkamu Getie-Kebtie, Nefele Giarratana, Madelyn A. Gillentine, Christopher Grunseich, Mirabelle S.H. Ho, Miriel S.H. Ho, Deborah A. Hursh, Gentaro Ikeda, Ji Hye Jung, Martin H. Kang, Yong Kyun Kim, Jacqueline Kowitz, Siegfried Lang, Onofrio Laselva, Jennifer Lei, Sandra L. Leibel, Clifford L. Librach, Geoffrey P. Lomax, Maryam Mahmoodinia Maymand, Rachael N. McVicar, Andrew R. Mendelsohn, Anna R. Mendelsohn, Sadegh lotfalah Moradi, Yasuhiro Murakawa, Dan Nir, Connor G. O'Brien, A.D. Podgurskaya, Natalia S. Pripuzova, Maurilio Sampaolesi, M.M. Slotvitsky, Evan Y. Snyder, Shi Su, Colin Sweeney, Bernard Thébaud, V.A. Tsvelaya, Haritha Vallabhaneni, Evgeniya A. Vaskova, Huaxiao Yang, Phillip C. Yang, Laura Yedigaryan, Masahito Yoshihara, and Xiaobo Zhou

Published
2022

4. Contributors

Author

Rohan Bhattacharya, Dandan Cao, Wai-Yee Chan, Julia Deinsberger, Andreas M. Grabrucker, Suyu Hao, Miriel S.H. Ho, Mirabelle S.H. Ho, K.A. Kilian, Clifford L. Librach, Savitri Maddileti, Shin-Ichi Mae, Siobhan Malany, Sigita Malijauskaite, Indumathi Mariappan, Kieran McGourty, Guo-li Ming, Kenji Mishima, Kai-Kei Miu, John J.E. Mulvihill, Samira Musah, Phuong T.T. Nguyen, Arinze Emmanuel Okafor, Kenji Osafune, Maddalena Parafati, Vinay Kumar Pulimamidi, Samantha Robertson, S. Romanazzo, I. Roohani, Makoto Ryosaka, Yasuo Saijo, Hongjun Song, Masatoshi Suzuki, Junichi Tanaka, Sin-Ruow Tey, Zhangting Wang, Benedikt Weber, and Qiliang Zhou

Published
2021

5. Looking back, moving forward

Author

Mirabelle S.H. Ho, Miriel S.H. Ho, and Clifford L. Librach

Subjects
Totemism, medicine.anatomical_structure, medicine, Organoid, The Renaissance, Biology, Stem cell, Induced pluripotent stem cell, Neuroscience, Regenerative medicine, Human lung
Abstract

Since the totemic achievement of human-induced pluripotent stem cells (iPSCs) in the stem cell field, we have witnessed a remarkable expansion in publications related to this discovery that could have central relevance to health and disease. One example of an offshoot from this achievement was the differentiation of iPSCs utilizing 3D in vitro models that resulted in the formation of organoids, such as lung organoids. These fascinating miniature organs are robustly generated through the process of self-assembly in response to morphogenetic cues. Organoids beautifully resemble the architecture and function of their in vivo counterparts. The marriage of this system and genome-editing techniques has powerfully advanced our knowledge of human lung biology, disease modeling, and drug discoveries, particularly where animal models are limited. Presently, human iPSC–derived lung organoids are developmentally nascent compared to their adult tissues. A deeper comprehension of the principles governing lung organogenesis combined with “lung-on-a-chip” technology could reconcile diverse cellular, vascular, and matrix strategies to reconstruct a complete niche in vitro. Ultimately, future progress is dependent on the convergence of multiple disciplines of biomedical science. The epochal impact of iPSC-lung organoid studies heralds their coming-of-age in creating novel, personalized therapeutics for regenerative medicine.

Published
2021

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