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1. Connecting NeRFs, Images, and Text

Author

Ballerini, Francesco, Ramirez, Pierluigi Zama, Mirabella, Roberto, Salti, Samuele, and Di Stefano, Luigi

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Neural Radiance Fields (NeRFs) have emerged as a standard framework for representing 3D scenes and objects, introducing a novel data type for information exchange and storage. Concurrently, significant progress has been made in multimodal representation learning for text and image data. This paper explores a novel research direction that aims to connect the NeRF modality with other modalities, similar to established methodologies for images and text. To this end, we propose a simple framework that exploits pre-trained models for NeRF representations alongside multimodal models for text and image processing. Our framework learns a bidirectional mapping between NeRF embeddings and those obtained from corresponding images and text. This mapping unlocks several novel and useful applications, including NeRF zero-shot classification and NeRF retrieval from images or text., Comment: Accepted at CVPRW-INRV 2024

Published
2024

10. Geophysical downhole logging analysis within the shallow-depth ICDP STAR drilling project (central Italy)

Author

P. Montone, S. Pierdominici, M. T. Mariucci, F. Mirabella, M. Urbani, A. Akimbekova, L. Chiaraluce, W. Johnson, and M. R. Barchi

Subjects
Geology, QE1-996.5, Stratigraphy, QE640-699
Abstract

The International Continental Scientific Drilling Program (ICDP) STAR (A Strainmeter Array Along the Alto Tiberina Fault System) drilling project aims to study the seismic and aseismic fault slip behavior of the active low-angle Alto Tiberina normal fault (ATF) in the northern Apennines, central Italy, by drilling and instrumenting six shallow boreholes (maximum depth 160 m) with seismometers and strainmeters. During the STAR fieldwork, a geophysical downhole logging campaign was carried out to define the optimal target depth for instrument deployment and formation rock characterization. In particular, the main objectives of this study were to define in situ physical properties of the rocks and the tectonic discontinuity geometry along the boreholes. The downhole logging data provide new findings and knowledge, especially with regards to physical properties such as resistivity and gamma-ray and wave velocity. The collected parameters were compared to the results of literature data collected in similar lithologies, as well as with the results of logging performed in deeper wells drilled for commercial purposes. The physical properties of the Mesozoic–early Tertiary calcareous formations show low gamma-ray values and high compressional (Vp) and shear wave (Vs) velocities (up to 5.3 and 2.9 km s−1, respectively), whereas the overlying clay-rich Late Tertiary formations exhibit high gamma-ray and low resistivity values as well as relatively low Vp and Vs values (up to 3.5 and 2.0 km s−1, respectively). The results obtained from the analysis of the orientations of the tectonic structures, measured along the six boreholes, show good agreement with the orientations of the present-day extensional stress field, which is NE–SW-oriented. Our study allowed us to bridge the gap between the physical properties obtained from literature data and those obtained from the deep well measurements, representing a possible case history for future projects. These new outcomes represent an almost unexplored window of data and will contribute to the advancement of knowledge of the physical properties of the rocks at shallow depths, which are typically overlooked.

Published
2024
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11. Water Structures Reveal Local Hydrophobicity on the In2O3(111) Surface

Author

Chen, Hao, Blatnik, Matthias A., Ritterhoff, Christian L., Sokolović, Igor, Mirabella, Francesca, Franceschi, Giada, Riva, Michele, Schmid, Michael, Čechal, Jan, Meyer, Bernd, Diebold, Ulrike, and Wagner, Margareta

Subjects
Condensed Matter - Materials Science
Abstract

Clean oxide surfaces are generally hydrophilic. Water molecules anchor at undercoordinated surface metal atoms that act as Lewis-acid sites, and they are stabilized by H bonds to undercoordinated surface oxygens. The large unit cell of In2O3(111) provides surface atoms in various configurations, which leads to chemical heterogeneity and a local deviation from this general rule. Experiments (TPD, XPS, ncAFM) agree quantitatively with DFT calculations and show a series of distinct phases. The first three water molecules dissociate at one specific area of the unit cell and desorb above room temperature. The next three adsorb as molecules in the adjacent region. Three more water molecules rearrange this structure and an additional nine pile up above the OH groups. Despite offering undercoordinated In and O sites, the rest of the unit cell is unfavorable for adsorption and remains water-free. The first water layer thus shows ordering into nanoscopic 3D water clusters separated by hydrophobic pockets.

Published
2023
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17. Context matters: task relevance shapes neural responses to emotional facial expressions

Author

Giovanni Mirabella, Maria Giulia Tullo, Gabriele Sberna, and Gaspare Galati

Subjects
Emotional facial expressions, Functional magnetic resonance, Task-relevance, Go/no-go task, Goal-directed actions, Medicine, Science
Abstract

Abstract Recent research shows that emotional facial expressions impact behavioral responses only when their valence is relevant to the task. Under such conditions, threatening faces delay attentional disengagement, resulting in slower reaction times and increased omission errors compared to happy faces. To investigate the neural underpinnings of this phenomenon, we used functional magnetic resonance imaging to record the brain activity of 23 healthy participants while they completed two versions of the go/no-go task. In the emotion task (ET), participants responded to emotional expressions (fearful or happy faces) and refrained from responding to neutral faces. In the gender task (GT), the same images were displayed, but participants had to respond based on the posers’ gender. Our results confirmed previous behavioral findings and revealed a network of brain regions (including the angular gyrus, the ventral precuneus, the left posterior cingulate cortex, the right anterior superior frontal gyrus, and two face-responsive regions) displaying distinct activation patterns for the same facial emotional expressions in the ET compared to the GT. We propose that this network integrates internal representations of task rules with sensory characteristics of facial expressions to evaluate emotional stimuli and exert top-down control, guiding goal-directed actions according to the context.

Published
2024
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18. The screening accuracy of the Edinburgh Postnatal Depression Scale (EPDS) to detect perinatal depression with and without the self-harm item in pregnant and postpartum women

Author

Alberto Stefana, Fiorino Mirabella, Antonella Gigantesco, and Laura Camoni

Subjects
Edinburgh Postnatal Depression Scale, perinatal depression, self-harm, suicidal ideation, screening sensitivity, Gynecology and obstetrics, RG1-991
Abstract

Background This study aims to examine whether the Edinburgh Postnatal Depression Scale (EPDS), excluding the self-harm item (EPDS-9), performs as effectively as the full EPDS in identifying depression among perinatal women.Methods A total of 3571 pregnant women and 3850 postpartum women participated in this observational study. Participants who scored ≥ 9 on the EPDS underwent further diagnostic evaluations by a clinical psychologist and/or psychiatrist.Results The EPDS-9 and full EPDS demonstrated a near-perfect correlation in both the antepartum (r = 0.996) and postpartum (r = 0.998) cohorts. EPDS-9 showed exceptional precision in identifying depression as screened by the full EPDS at cutoff points ranging 9–14, with areas under the curve ≥0.998. The sensitivity of EPDS-9 and full EPDS to detect depression that requires psychotropic medications was poor. The highest accuracy for both versions was at a cutoff score of 9: sensitivity of 0.579 for the full EPDS and 0.526 for the EPDS-9. At the cutoff point of 9, EPDS-9 performed adequately in predicting the response of the participants to the self-harm item.Conclusion The EPDS-9 represents a solid and effective replacement for the full EPDS in clinical settings. If the presence of suicidal thoughts needs to be assessed, specialized scales should be used.

Published
2024
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24. Parametric Analysis of Ribbed Domes

Author

Mirabella Roberti, Giulio, Paris, Vittorio, Ruscica, Giuseppe, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Gabriele, Stefano, editor, Manuello Bertetto, Amedeo, editor, Marmo, Francesco, editor, and Micheletti, Andrea, editor

Published
2024
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26. ATHENA Detector Proposal -- A Totally Hermetic Electron Nucleus Apparatus proposed for IP6 at the Electron-Ion Collider

Author

ATHENA Collaboration, Adam, J., Adamczyk, L., Agrawal, N., Aidala, C., Akers, W., Alekseev, M., Allen, M. M., Ameli, F., Angerami, A., Antonioli, P., Apadula, N. J., Aprahamian, A., Armstrong, W., Arratia, M., Arrington, J. R., Asaturyan, A., Aschenauer, E. C., Augsten, K., Aune, S., Bailey, K., Baldanza, C., Bansal, M., Barbosa, F., Barion, L., Barish, K., Battaglieri, M., Bazilevsky, A., Behera, N. K., Berdnikov, V., Bernauer, J., Berriaud, C., Bhasin, A., Bhattacharya, D. S., Bielcik, J., Bielcikova, J., Bissolotti, C., Boeglin, W., Bondì, M., Borri, M., Bossu, F., Bouyjou, F., Brandenburg, J. D., Bressan, A., Brooks, M., Bueltmann, S. L., Byer, D., Caines, H., Sanchez, M. Calderon de la Barca, Calvelli, V., Camsonne, A., Cappelli, L., Capua, M., Castro, M., Cavazza, D., Cebra, D., Celentano, A., Chakaberia, I., Chan, B., Chang, W., Chartier, M., Chatterjee, C., Chen, D., Chen, J., Chen, K., Chen, Z., Chetri, H., Chiarusi, T., Chiosso, M., Chu, X., Chwastowski, J. J., Cicala, G., Cisbani, E., Cline, E., Cloet, I., Colella, D., Contalbrigo, M., Contin, G., Corliss, R., Corrales-Morales, Y., Crafts, J., Crawford, C., Cruz-Torres, R., D'Ago, D., D'Angelo, A., D'Hose, N., Dainton, J., Torre, S. Dalla, Dasgupta, S. S., Dash, S., Dashyan, N., Datta, J., Daugherity, M., De Vita, R., Deconinck, W., Defurne, M., Dehmelt, K., Del Dotto, A., Delcarro, F., Dellacasa, G., Demiroglu, Z. S., Deptuch, G. W., Desai, V., Deshpande, A., Devereaux, K., Dhillon, R., Di Salvo, R., Dilks, C., Dixit, D., Dobbs, S., Dong, X., Drachenberg, J., Drees, A., Dupre, R., Durham, M., Dzhygadlo, R., Fassi, L. El, Elia, D., Epple, E., Esha, R., Evdokimov, O., Eyser, O., Falchieri, D., Fan, W., Fantini, A., Fatemi, R., Fazio, S., Fegan, S., Filippi, A., Fox, H., Francisco, A., Freeze, A., Furletov, S., Furletova, Y., Gal, C., Gardner, S., Garg, P., Gaskell, D., Gates, K., Gericke, M. T. W., Geurts, F., Ghosh, C., Giacalone, M., Giacomini, F., Gilchrist, S., Glazier, D., Gnanvo, K., Gonella, L., Greiner, L. C., Guerrini, N., Guo, L., Gupta, A., Gupta, R., Guryn, W., He, X., Hemmick, T., Heppelmann, S., Higinbotham, D., Hoballah, M., Hoghmrtsyan, A., Hohlmann, M., Horn, T., Hornidge, D., Huang, H. Z., Hyde, C. E., Iapozzuto, P., Idzik, M., Jacak, B. V., Jadhav, M., Jain, S., Jena, C., Jentsch, A., Ji, Y., Ji, Z., Jia, J., Jones, P. G., Jones, R. W. I., Joosten, S., Joshi, S., Kabir, L., Kalicy, G., Karyan, G., Kashyap, V. K. S., Kawall, D., Ke, H., Kelsey, M., Kim, J., Kiryluk, J., Kiselev, A., Klein, S. R., Klest, H., Kochar, V., Korsch, W., Kosarzewski, L., Kotzinian, A., Krizek, F., Kumar, A., Kumar, K. S., Kumar, L., Kumar, R., Kumar, S., Kunnath, A., Kushawaha, N., Lacey, R., Lai, Y. S., Lalwani, K., Landgraf, J., Lanza, L., Lattuada, D., Lavinsky, M., Lee, J. H., Lee, S. H., Lemmon, R., Lestone, A., Lewis, N., Li, H., Li, S., Li, W., Li, X., Liang, X., Ligonzo, T., Lin, T., Liu, J., Liu, K., Liu, M., Livingston, K., Liyanage, N., Ljubicic, T., Long, O., Lukow, N., Ma, Y., Mammei, J., Mammoliti, F., Mamo, K., Mandjavidze, I., Maple, S., Marchand, D., Margotti, A., Markert, C., Markowitz, P., Marshall, T., Martin, A., Marukyan, H., Mastroserio, A., Mathew, S., Mayilyan, S., Mayri, C., McEneaney, M., Mei, Y., Meng, L., Meot, F., Metcalfe, J., Meziani, Z. -E., Mihir, P., Milton, R., Mirabella, A., Mirazita, M., Mkrtchyan, A., Mkrtchyan, H., Mohanty, B., Mondal, M., Morreale, A., Movsisyan, A., Muenstermann, D., Mukherjee, A., Camacho, C. Munoz, Murray, M. J., Mustafa, H., Myska, M., Nachman, B. P., Nagai, K., Naik, R., Naim, J. P., Nam, J., Nandi, B., Nappi, E., Nasim, Md., Neff, D., Neiret, D., Newman, P. R., Nguyen, M., Niccolai, S., Nie, M., Noferini, F., Norman, J., Noto, F., Nunes, A. S., O'Connor, T., Odyniec, G., Okorokov, V. A., Osipenko, M., Page, B., Palatchi, C., Palmer, D., Palni, P., Pandey, S., Panzieri, D., Park, S., Paschke, K., Pastore, C., Patra, R. N., Paul, A., Paul, S., Pecar, C., Peck, A., Pegg, I., Pellegrino, C., Peng, C., Pentchev, L., Perrino, R., Piotrzkowski, K., Polakovic, T., Ploskon, M., Posik, M., Prasad, S., Preghenella, R., Priens, S., Prifti, E., Przybycien, M., Pujahari, P., Quintero, A., Radici, M., Radhakrishnan, S. K., Rahman, S., Rathi, S., Raue, B., Reed, R., Reimer, P., Reinhold, J., Renner, E., Rignanese, L., Ripani, M., Rizzo, A., Romanov, D., Roy, A., Rubini, N., Ruspa, M., Ruan, L., Sabatie, F., Sadhukhan, S., Sahoo, N., Sahu, P., Samuel, D., Sarkar, A., Sarsour, M., Schmidke, W., Schmookler, B., Schwarz, C., Schwiening, J., Scott, M., Sedgwick, I., Segreti, M., Sekula, S., Seto, R., Shah, N., Shahinyan, A., Sharma, D., Sharma, N., Sichtermann, E. P., Signori, A., Singh, A., Singh, B. K., Singh, S. N., Smirnov, N., Sokhan, D., Soltz, R., Sondheim, W., Spinali, S., Stacchi, F., Staszewski, R., Stepanov, P., Strazzi, S., Stroe, I. R., Sun, X., Surrow, B., Sweger, Z., Symons, T. J., Tadevosyan, V., Tang, A., Tassi, E., Teodorescu, L., Tessarotto, F., Thomas, D., Thomas, J. H., Toll, T., Tomasek, L., Torales-Acosta, F., Tribedy, P., Triloki, Tripathi, V., Trotta, R., Trzebiński, M., Trzeciak, B. A., Tsai, O., Tu, Z., Turrisi, R., Tuve, C., Ullrich, T., Urciuoli, G. M., Valentini, A., Vallarino, S., Vandenbroucke, M., Vanek, J., Vino, G., Volpe, G., Voskanyan, H., Vossen, A., Voutier, E., Wang, G., Wang, Y., Watts, D., Wickramaarachchi, N., Wilson, F., Wong, C. -P., Wu, X., Wu, Y., Xie, J., Xu, Q. -H., Xu, Z., Xu, Z. W., Yang, C., Yang, Q., Yang, Y., Ye, Z., Yi, L., Yin, Z., Yurov, M., Zachariou, N., Zhang, J., Zhang, Y., Zhang, Z., Zhao, Y., Zhao, Y. X., Zhao, Z., Zheng, L., and Zurek, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract

ATHENA has been designed as a general purpose detector capable of delivering the full scientific scope of the Electron-Ion Collider. Careful technology choices provide fine tracking and momentum resolution, high performance electromagnetic and hadronic calorimetry, hadron identification over a wide kinematic range, and near-complete hermeticity. This article describes the detector design and its expected performance in the most relevant physics channels. It includes an evaluation of detector technology choices, the technical challenges to realizing the detector and the R&D required to meet those challenges.

Published
2022

29. A strainmeter array as the fulcrum of novel observatory sites along the Alto Tiberina Near Fault Observatory

Author

L. Chiaraluce, R. Bennett, D. Mencin, W. Johnson, M. R. Barchi, M. Bohnhoff, P. Baccheschi, A. Caracausi, C. Calamita, A. Cavaliere, A. Gualandi, E. Mandler, M. T. Mariucci, L. Martelli, S. Marzorati, P. Montone, D. Pantaleo, S. Pucci, E. Serpelloni, M. Supino, S. Stramondo, C. Hanagan, L. Van Boskirk, M. Gottlieb, G. Mattioli, M. Urbani, F. Mirabella, A. Akimbekova, S. Pierdominici, T. Wiersberg, C. Marone, L. Palmieri, and L. Schenato

Subjects
Geology, QE1-996.5
Abstract

Fault slip is a complex natural phenomenon involving multiple spatiotemporal scales from seconds to days to weeks. To understand the physical and chemical processes responsible for the full fault slip spectrum, a multidisciplinary approach is highly recommended. The Near Fault Observatories (NFOs) aim at providing high-precision and spatiotemporally dense multidisciplinary near-fault data, enabling the generation of new original observations and innovative scientific products. The Alto Tiberina Near Fault Observatory is a permanent monitoring infrastructure established around the Alto Tiberina fault (ATF), a 60 km long low-angle normal fault (mean dip 20°), located along a sector of the Northern Apennines (central Italy) undergoing an extension at a rate of about 3 mm yr−1. The presence of repeating earthquakes on the ATF and a steep gradient in crustal velocities measured across the ATF by GNSS stations suggest large and deep (5–12 km) portions of the ATF undergoing aseismic creep. Both laboratory and theoretical studies indicate that any given patch of a fault can creep, nucleate slow earthquakes, and host large earthquakes, as also documented in nature for certain ruptures (e.g., Iquique in 2014, Tōhoku in 2011, and Parkfield in 2004). Nonetheless, how a fault patch switches from one mode of slip to another, as well as the interaction between creep, slow slip, and regular earthquakes, is still poorly documented by near-field observation. With the strainmeter array along the Alto Tiberina fault system (STAR) project, we build a series of six geophysical observatory sites consisting of 80–160 m deep vertical boreholes instrumented with strainmeters and seismometers as well as meteorological and GNSS antennas and additional seismometers at the surface. By covering the portions of the ATF that exhibits repeated earthquakes at shallow depth (above 4 km) with these new observatory sites, we aim to collect unique open-access data to answer fundamental questions about the relationship between creep, slow slip, dynamic earthquake rupture, and tectonic faulting.

Published
2024
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30. Nutrition management and early rehabilitation in ICU pregnant with hyperemesis gravidarum complicated by central pontine myelinolysis: A case report

Author

Antonella Cotoia, Giuseppe Ferrara, Michela Rauseo, Michela Brattoli, Lea Pia Cantatore, Stefania Da Lima, Marcello Chinni, Chiara Ciritella, Lucia Mirabella, and Gilda Cinnella

Subjects
Multidisciplinary treatment, Hyperemesis gravidarum, Central Pontine myelinolysis, Nutrition, Nutrition. Foods and food supply, TX341-641
Abstract

Summary: Our case report aims to highlight the multidisciplinary approach adopted for the avoidance of ICU-acquired weakness and the assessment of nutritional therapy in 16 weeks young pregnant with diagnosis of hyperemesis gravidarum complicated with central pontine myelinolysis, after the development of acute respiratory failure due to pneumonia.Thiamine and electrolytes were properly supplemented to minimize the high risk of developing refeeding syndrome. Due to severe nausea and vomiting, antiemetic therapy was started and a parenteral route was chosen during the first two days of non-invasive ventilation. On day three, the patient was intubated and mechanically ventilated due to severe respiratory failure, semi-elemental formula was started by enteral route while parenteral nutrition was supplemented and early rehabilitation was started. Antiemetic therapy was continued until day 28th when the pregnant woman was shifted to oral nutrition only. On day 87th the postpartum mother was transferred to the rehabilitation center for an intensive rehabilitative program based on the motor recovery of lower limb and swallowing recovery.

Published
2024
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31. The first absolute gravity and height reference network in Sicily

Author

Filippo Greco, Giovanna Berrino, Federica Riguzzi, Augusto Mazzoni, Matteo Amendola, Daniele Carbone, Danilo Contrafatto, Gino Dardanelli, Mauro Lo Brutto, Antonino Maltese, Alfio Messina, Luca Mirabella, Giuseppe Ricciardi, and Luca Samperi

Subjects
Science
Abstract

Abstract The purpose of this work is to provide the methodological and instrumental framework for the establishment of a new absolute gravity and height reference network in Sicily. The aim of the network is to contribute to the new reference systems in the Italian area, useful for the scientific and technological activities related to the gravity field and to the proper definition of a modern height system in this region. The network is composed of 5 stations, evenly distributed to form a large mesh, which roughly covers the entire Sicily. Since four of the five selected stations were measured also in the 1990s, it was also possible to evaluate whether long-term gravity changes occurred at these sites (basic requirement for a reference network) and check the long-term ground deformation patterns, using data from the closest GPS/GNSS stations. The observed gravity changes over a time interval of about 30 years at the absolute stations and in the surrounding areas, confirm the long-term stability of the selected areas/sites.

Published
2024
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32. Multiscale modeling uncovers 7q11.23 copy number variation-dependent changes in ribosomal biogenesis and neuronal maturation and excitability

Author

Mihailovich, Marija, Germain, Pierre-Luc, Shyti, Reinald, Pozzi, Davide, Noberini, Roberta, Liu, Yansheng, Aprile, Davide, Tenderini, Erika, Troglio, Flavia, Trattaro, Sebastiano, Fabris, Sonia, Ciptasari, Ummi, Rigoli, Marco Tullio, Caporale, Nicolo, D'Agostino, Giuseppe, Mirabella, Filippo, Vitriolo, Alessandro, Capocefalo, Daniele, Skaros, Adrianos, Franchini, Agnese Virginia, Ricciardi, Sara, Biunno, Ida, Neri, Antonino, Kasri, Nael Nadif, Bonaldi, Tiziana, Aebersold, Rudolf, Matteoli, Michela, and Testa, Giuseppe

Subjects
Neurons -- Genetic aspects -- Health aspects, Gene expression -- Research, Child development deviations -- Risk factors -- Genetic aspects, Nervous system diseases -- Risk factors -- Genetic aspects, Ribosomes -- Genetic aspects -- Health aspects, Cell organelles -- Formation, Neurological research, Copy number variations -- Research, Developmental disabilities -- Risk factors -- Genetic aspects, Health care industry
Abstract

Copy number variation (CNV) at 7q11.23 causes Williams-Beuren syndrome (WBS) and 7q microduplication syndrome (7Dup), neurodevelopmental disorders (NDDs) featuring intellectual disability accompanied by symmetrically opposite neurocognitive features. Although significant progress has been made in understanding the molecular mechanisms underlying 7q11.23- related pathophysiology, the propagation of CNV dosage across gene expression layers and their interplay remains elusive. Here we uncovered 7q11.23 dosage-dependent symmetrically opposite dynamics in neuronal differentiation and intrinsic excitability. By integrating transcriptomics, translatomics, and proteomics of patient-derived and isogenic induced neurons, we found that genes related to neuronal transmission follow 7q11.23 dosage and are transcriptionally controlled, while translational factors and ribosomal genes are posttranscriptionally buffered. Consistently, we found phosphorylated RPS6 (p-RPS6) downregulated in WBS and upregulated in 7Dup. Surprisingly, p-4EBP was changed in the opposite direction, reflecting dosage- specific changes in total 4EBP levels. This highlights different dosage-sensitive dyregulations of the mTOR pathway as well as distinct roles of p-RPS6 and p-4EBP during neurogenesis. Our work demonstrates the importance of multiscale disease modeling across molecular and functional layers, uncovers the pathophysiological relevance of ribosomal biogenesis in a paradigmatic pair of NDDs, and uncouples the roles of p-RPS6 and p-4EBP as mechanistically actionable relays in NDDs., Introduction With over a thousand associated genes and an increasing number of polygenic risk variants, neurodevelopmental disorders (NDDs), in particular autism spectrum disorder (ASD) and intellectual disability (ID), continue to [...]

Published
2024
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33. Cladribine effects on patient-reported outcomes and their clinical and biometric correlates in highly active relapsing multiple sclerosis at first switch: the observational, multicenter, prospective, phase IV CLADFIT-MS study

Author

Giovanna Borriello, Clara Grazia Chisari, Davide Maimone, Massimiliano Mirabella, Damiano Paolicelli, Francesco Assogna, Sandro Caradonna, and Francesco Patti

Subjects
relapsing–remitting multiple sclerosis, disease-modifying treatment, cladribine tablets, observational study, patient-reported outcomes, wearable devices, Neurology. Diseases of the nervous system, RC346-429
Abstract

Patient-reported outcomes (PROs) are essential for understanding the effects of MS and its treatments on patients’ lives; they play an important role in multiple sclerosis (MS) research and practice. We present the protocol for an observational study to prospectively assess the effect of cladribine tablets on PROs and their correlation to disability and physical activity in adults with highly active relapsing MS switching from a first disease modifying drug (DMD) to cladribine tablets in routine clinical practice at study sites in Italy. The primary objective will be to evaluate changes from baseline in the impact of highly active MS on self-assessed physical functioning 52 weeks after the switch to cladribine tablets using the Multiple Sclerosis Impact Scale-29 (MSIS-29). Secondary objectives will include self-assessed psychological impact of highly active MS in daily life and general health after the switch to cladribine tablets as well as changes in cognitive function, anxiety, and depression symptoms. Additional PRO measures will include the Hospital Anxiety and Depression Scale (HADS), the EuroQoL 5-Dimension 5-Level (EQ-5D-5L), the Work Productivity and Activity Impairment Questionnaire: Multiple Sclerosis (WPAI:MS), and the Patient-Reported Outcomes Measurement Information System (PROMIS). Wearable devices will acquire activity data (step counts, walking speed, time asleep, and energy expenditure). Additional clinical, radiological, and laboratory data will be collected when available during routine management. The findings will complement data from controlled trials by providing insight from daily clinical practice into the effect of cladribine tablets on the patient’s experience and self-assessed impact of treatment on daily life.

Published
2024
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36. Water Structures Reveal Local Hydrophobicity on the In2O3(111) Surface.

Author

Chen, Hao, Blatnik, Matthias, Ritterhoff, Christian, Sokolović, Igor, Mirabella, Francesca, Franceschi, Giada, Riva, Michele, Schmid, Michael, Čechal, Jan, Meyer, Bernd, Diebold, Ulrike, and Wagner, Margareta

Subjects
ab initio molecular dynamics simulations, atomic force microscopy, density functional theory, indium oxide, temperature-programmed desorption, water adsorption, water on oxides
Abstract

Clean oxide surfaces are generally hydrophilic. Water molecules anchor at undercoordinated surface metal atoms that act as Lewis acid sites, and they are stabilized by H bonds to undercoordinated surface oxygens. The large unit cell of In2O3(111) provides surface atoms in various configurations, which leads to chemical heterogeneity and a local deviation from this general rule. Experiments (TPD, XPS, nc-AFM) agree quantitatively with DFT calculations and show a series of distinct phases. The first three water molecules dissociate at one specific area of the unit cell and desorb above room temperature. The next three adsorb as molecules in the adjacent region. Three more water molecules rearrange this structure and an additional nine pile up above the OH groups. Despite offering undercoordinated In and O sites, the rest of the unit cell is unfavorable for adsorption and remains water-free. The first water layer thus shows ordering into nanoscopic 3D water clusters separated by hydrophobic pockets.

Published
2022

38. Sex dependence of postoperative pulmonary complications – A post hoc unmatched and matched analysis of LAS VEGAS

Author

Kroell, Wolfgang, Metzler, Helfried, Struber, Gerd, Wegscheider, Thomas, Gombotz, Hans, Hiesmayr, Michael, Schmid, Werner, Urbanek, Bernhard, Kahn, David, Momeni, Mona, Pospiech, Audrey, Lois, Fernande, Forget, Patrice, Grosu, Irina, Poelaert, Jan, van Mossevelde, Veerle, van Malderen, Marie-Claire, Dylst, Dimitri, van Melkebeek, Jeroen, Beran, Maud, de Hert, Stefan, De Baerdemaeker, Luc, Heyse, Bjorn, Van Limmen, Jurgen, Wyffels, Piet, Jacobs, Tom, Roels, Nathalie, De Bruyne, Ann, van de Velde, Stijn, Leva, Brigitte, Damster, Sandrine, Plichon, Benoit, Juros-Zovko, Marina, Djonoviċ-Omanoviċ, Dejana, Pernar, Selma, Zunic, Josip, Miskovic, Petar, Zilic, Antonio, Kvolik, Slavica, Ivic, Dubravka, Azenic-Venzera, Darija, Skiljic, Sonja, Vinkovic, Hrvoje, Oputric, Ivana, Juricic, Kazimir, Frkovic, Vedran, Kopic, Jasminka, Mirkovic, Ivan, Karanovic, Nenad, Carev, Mladen, Dropulic, Natasa, Saric, Jadranka Pavicic, Erceg, Gorjana, Dvorscak, Matea Bogdanovic, Mazul-Sunko, Branka, Pavicic, Anna Marija, Goranovic, Tanja, Maldini, Branka, Radocaj, Tomislav, Gavranovic, Zeljka, Mladic-Batinica, Inga, Sehovic, Mirna, Stourac, Petr, Harazim, Hana, Smekalova, Olga, Kosinova, Martina, Kolacek, Tomas, Hudacek, Kamil, Drab, Michal, Brujevic, Jan, Vitkova, Katerina, Jirmanova, Katerina, Volfova, Ivana, Dzurnakova, Paula, Liskova, Katarina, Dudas, Radovan, Filipsky, Radek, el Kafrawy, Samir, Abdelwahab, Hisham Hosny, Metwally, Tarek, Abdel-Razek, Ahmed, El-Shaarawy, Ahmed Mostafa, Hasan, Wael Fathy, Ahmed, Ahmed Gouda, Yassin, Hany, Magdy, Mohamed, Abdelhady, Mahdy, Mahran, Mohamed, Herodes, Eiko, Kivik, Peeter, Oganjan, Juri, Aun, Annika, Sormus, Alar, Sarapuu, Kaili, Mall, Merilin, Karjagin, Juri, Futier, Emmanuel, Petit, Antoine, Gerard, Adeline, Marret, Emmanuel, Solier, Marc, Jaber, Samir, Prades, Albert, Krassler, Jens, Merzky, Simone, de Abreu, Marcel Gama, Uhlig, Christopher, Kiss, Thomas, Bundy, Anette, Bluth, Thomas, Gueldner, Andreas, Spieth, Peter, Scharffenberg, Martin, Thiem, Denny Tran, Koch, Thea, Treschan, Tanja, Schaefer, Maximilian, Bastin, Bea, Geib, Johann, Weiss, Martin, Kienbaum, Peter, Pannen, Benedikt, Gottschalk, Andre, Konrad, Mirja, Westerheide, Diana, Schwerdtfeger, Ben, Wrigge, Hermann, Simon, Philipp, Reske, Andreas, Nestler, Christian, Valsamidis, Dimitrios, Stroumpoulis, Konstantinos, Antholopoulos, Georgios, Andreou, Antonis, Karapanos, Dimitris, Theodoraki, Kassiani, Gkiokas, Georgios, Tasoulis, Marios-Konstantinos, Sidiropoulou, Tatiana, Zafeiropoulou, Foteini, Florou, Panagiota, Pandazi, Aggeliki, Tsaousi, Georgia, Nouris, Christos, Pourzitaki, Chryssa, Bystritski, Dmitri, Pizov, Reuven, Eden, Arieh, Pesce, Caterina Valeria, Campanile, Annamaria, Marrella, Antonella, Grasso, Salvatore, De Michele, Michele, Bona, Francesco, Giacoletto, Gianmarco, Sardo, Elena, Sottosanti, Luigi Giancarlo Vicari, Solca, Maurizio, Volta, Carlo Alberto, Spadaro, Savino, Verri, Marco, Ragazzi, Riccardo, Zoppellari, Roberto, Cinnella, Gilda, Raimondo, Pasquale, La Bella, Daniela, Mirabella, Lucia, D'antini, Davide, Pelosi, Paolo, Molin, Alexandre, Brunetti, Iole, Gratarola, Angelo, Pellerano, Giulia, Sileo, Rosanna, Pezzatto, Stefano, Montagnani, Luca, Pasin, Laura, Landoni, Giovanni, Zangrillo, Alberto, Beretta, Luigi, Di Parma, Ambra Licia, Tarzia, Valentina, Dossi, Roberto, Sassone, Marta Eugenia, Sances, Daniele, Tredici, Stefano, Spano, Gianluca, Castellani, Gianluca, Delunas, Luigi, Peradze, Sopio, Venturino, Marco, Arpino, Ines, Sher, Sara, Tommasino, Concezione, Rapido, Francesca, Morelli, Paola, Vargas, Maria, Servillo, Giuseppe, Cortegiani, Andrea, Raineri, Santi Maurizio, Montalto, Francesca, Russotto, Vincenzo, Giarratano, Antonino, Baciarello, Marco, Generali, Michela, Cerati, Giorgia, Leykin, Yigal, Bressan, Filippo, Bartolini, Vittoria, Zamidei, Lucia, Brazzi, Luca, Liperi, Corrado, Sales, Gabriele, Pistidda, Laura, Severgnini, Paolo, Brugnoni, Elisa, Musella, Giuseppe, Bacuzzi, Alessandro, Muhardri, Dalip, Gecaj-Gashi, Agreta, Sada, Fatos, Bytyqi, Adem, Karbonskiene, Aurika, Aukstakalniene, Ruta, Teberaite, Zivile, Salciute, Erika, Tikuisis, Renatas, Miliauskas, Povilas, Jurate, Sipylaite, Kontrimaviciute, Egle, Tomkute, Gabija, Xuereb, John, Bezzina, Maureen, Borg, Francis Joseph, Hemmes, Sabrine, Schultz, Marcus, Hollmann, Markus, Wiersma, Irene, Binnekade, Jan, Bos, Lieuwe, Nijbroek, Sunny, Boer, Christa, Duvekot, Anne, ’t Veld, Bas in, Werger, Alice, Dennesen, Paul, Severijns, Charlotte, De Jong, Jasper, Hering, Jens, van Beek, Rienk, Ivars, Stefan, Jammer, Ib, Breidablik, Alena, Hodt, Katharina Skirstad, Fjellanger, Frode, Avalos, Manuel Vico, Mellin-Olsen, Jannicke, Andersson, Elisabeth, Shafi-Kabiri, Amir, Molina, Ruby, Wutai, Stanley, Morais, Erick, Tareco, Glória, Ferreira, Daniel, Amaral, Joana, de Lurdes Goncalves Castro, Maria, Cadilha, Susana, Appleton, Sofia, Parente, Suzana, Correia, Mariana, Martins, Diogo, Monteirosa, Angela, Ricardo, Ana, Rodrigues, Sara, Horhota, Lucian, Grintescu, Ioana Marina, Mirea, Liliana, Grintescu, Ioana Cristina, Corneci, Dan, Negoita, Silvius, Dutu, Madalina, Garotescu, Ioana Popescu, Filipescu, Daniela, Prodan, Alexandru Bogdan, Droc, Gabriela, Fota, Ruxandra, Popescu, Mihai, Tomescu, Dana, Petcu, Ana Maria, Tudoroiu, Marian Irinel, Moise, Alida, Guran, Catalin-Traian, Gherghina, Iorel, Costea, Dan, Cindea, Iulia, Copotoiu, Sanda-Maria, Copotoiu, Ruxandra, Barsan, Victoria, Tolcser, Zsolt, Riciu, Magda, Moldovan, Septimiu Gheorghe, Veres, Mihaly, Gritsan, Alexey, Kapkan, Tatyana, Gritsan, Galina, Korolkov, Oleg, Kulikov, Alexander, Lubnin, Andrey, Ovezov, Alexey, Prokoshev, Pavel, Lugovoy, Alexander, Anipchenko, Natalia, Babayants, Andrey, Komissarova, Irina, Zalina, Karginova, Likhvantsev, Valery, Fedorov, Sergei, Lazukic, Aleksandra, Pejakovic, Jasmina, Mihajlovic, Dunja, Kusnierikova, Zuzana, Zelinkova, Maria, Bruncakova, Katarina, Polakovicova, Lenka, Sobona, Villiam, Novak-Supe, Barbka, Pekle-Golez, Ana, Jovanov, Miroljub, Strazisar, Branka, Markovic-Bozic, Jasmina, Novak-Jankovic, Vesna, Voje, Minca, Grynyuk, Andriy, Kostadinov, Ivan, Spindler-Vesel, Alenka, Moral, Victoria, Unzueta, Mari Carmen, Puigbo, Carlos, Fava, Josep, Canet, Jaume, Moret, Enrique, Nunez, Mónica Rodriguez, Sendra, Mar, Brunelli, Andrea, Rodenas, Frederic, Monedero, Pablo, Martinezv, Francisco Hidalgo, Temino, Maria Jose Yepes, Simon, Antonio Martínez, de Abajo Larriba, Ana, Lisi, Alberto, Perez, Gisela, Martinez, Raquel, Granell, Manuel, Vivo, Jose Tatay, Ruiz, Cristina Saiz, de Andrés Ibañez, Jose Antonio, Pastor, Ernesto, Soro, Marina, Ferrando, Carlos, Defez, Mario, Alvares-Santullano, Cesar Aldecoa, Perez, Rocio, Rico, Jesus, Jawad, Monir, Saeed, Yousif, Gillberg, Lars, Hedenstierma, Göran, Bengisun, Zuleyha Kazak, Kazbek, Baturay Kansu, Coskunfirat, Nesil, Boztug, Neval, Sanli, Suat, Yilmaz, Murat, Hadimioglu, Necmiye, Senturk, Nuzhet Mert, Camci, Emre, Kucukgoncu, Semra, Sungur, Zerrin, Sivrikoz, Nukhet, Ozgen, Serpil Ustalar, Toraman, Fevzi, Selvi, Onur, Senturk, Ozgur, Yildiz, Mine, Kuvaki, Bahar, Gunenc, Ferim, Kucukguclu, Semih, Ozbilgin, Şule, Maral, Jale, Canli, Seyda, Arun, Oguzhan, Saltali, Ali, Aydogan, Eyup, Akgun, Fatma Nur, Sanlikarip, Ceren, Karaman, Fatma Mine, Mazur, Andriy, Vorotyntsev, Sergiy, Rousseau, Guy, Barrett, Colin, Stancombe, Lucia, Shelley, Ben, Scholes, Helen, Limb, James, Rafi, Amir, Wayman, Lisa, Deane, Jill, Rogerson, David, Williams, John, Yates, Susan, Rogers, Elaine, Pulletz, Mark, Moreton, Sarah, Jones, Stephanie, Venkatesh, Suresh, Burton, Maudrian, Brown, Lucy, Goodall, Cait, Rucklidge, Matthew, Fuller, Debbie, Nadolski, Maria, Kusre, Sandeep, Lundberg, Michael, Everett, Lynn, Nutt, Helen, Zuleika, Maka, Carvalho, Peter, Clements, Deborah, Creagh-Brown, Ben, Watt, Philip, Raymode, Parizade, Pearse, Rupert, Mohr, Otto, Raj, Ashok, Creary, Thais, Chishti, Ahmed, Bell, Andrea, Higham, Charley, Cain, Alistair, Gibb, Sarah, Mowat, Stephen, Franklin, Danielle, West, Claire, Minto, Gary, Boyd, Nicholas, Mills, Gary, Calton, Emily, Walker, Rachel, Mackenzie, Felicity, Ellison, Branwen, Roberts, Helen, Chikungwa, Moses, Jackson, Clare, Donovan, Andrew, Foot, Jayne, Homan, Elizabeth, Montgomery, Jane, Portch, David, Mercer, Pauline, Palmer, Janet, Paddle, Jonathan, Fouracres, Anna, Datson, Amanda, Andrew, Alyson, Welch, Leanne, Rose, Alastair, Varma, Sandeep, Simeson, Karen, Rambhatla, Mrutyunjaya, Susarla, Jaysimha, Marri, Sudhakar, Kodaganallur, Krishnan, Das, Ashok, Algarsamy, Shivarajan, Colley, Julie, Davies, Simon, Szewczyk, Margaret, Smith, Thomas, Fernandez-Bustamante, Ana, Luzier, Elizabeth, Almagro, Angela, Melo, Marcos Vidal, Fernando, Luiz, Sulemanji, Demet, Sprung, Juraj, Weingarten, Toby, Kor, Daryl, Scavonetto, Federica, Tze, Yeo, Vermeulen, Tom D., Hol, Liselotte, Swart, Pien, Mills, Gary H., Putensen, Christian, Serpa Neto, Ary, Vidal Melo, Marcos F., Hollmann, Markus W., Gama de Abreu, Marcelo, Schultz, Marcus J., Hemmes, Sabrine N., and van Meenen, David M.

Published
2024
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45. Effect of alemtuzumab on fatigue, quality of life, and patient/caregiver-reported outcomes in relapsing-remitting multiple sclerosis—A real-world evidence study

Author

Frederiksen, Jette Lautrup, Massacesi, Luca, Nielsen, Helle Hvilsted, Rini, Augusto, Baldi, Eleonora, Mirabella, Massimiliano, Antonella, Falzone Francesca Maria, Lus, Giacomo, Paolicelli, Damiano, Kant, Matthias, Salemi, Giuseppe, Aguglia, Umberto, Comi, Cristoforo, De Riz, Milena, Barcella, Valeria, Flemmen, Heidi Ø., Protti, Alessandra, Farbu, Elisabeth, van Exel, Job, and Torkildsen, Øivind

Published
2025
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48. Effectiveness of Ocrelizumab in Primary Progressive Multiple Sclerosis: a Multicenter, Retrospective, Real-world Study (OPPORTUNITY)

Author

Chisari, Clara G., Bianco, Assunta, Brescia Morra, Vincenzo, Calabrese, Massimiliano, Capone, Fioravante, Cavalla, Paola, Chiavazza, Carlotta, Comi, Cristoforo, Danni, Maura, Filippi, Massimo, Iaffaldano, Pietro, Lanzillo, Roberta, Lo Fermo, Salvatore, Lucisano, Alessandra, Lugaresi, Alessandra, Lus, Giacomo, Marfia, Gerolama Alessandra, Marinelli, Fabiana, Mirabella, Massimiliano, Moiola, Lucia, Perin, Chiara, Realmuto, Sabrina, Toscano, Simona, Trojano, Maria, Vecchio, Domizia, and Patti, Francesco

Published
2023
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49. Effectiveness of teriflunomide on No Evidence of Disease Activity and cognition in relapsing remitting multiple sclerosis: results of the NEDA3PLUS study

Author

Amato, Maria Pia, Bergamaschi, Roberto, Centonze, Diego, Mirabella, Massimiliano, Marfia, Girolama Alessandra, Totaro, Rocco, Lus, Giacomo, Brescia Morra, Vincenzo, Aguglia, Umberto, Comi, Cristoforo, Cavalla, Paola, Zaffaroni, Mauro, Rovaris, Marco, Grimaldi, Luigi Maria, Leoni, Stefania, Malucchi, Simona, Baldi, Eleonora, Romano, Marcello, Falcini, Mario, Perini, Paola, Assetta, Maurizio, Portaccio, Emilio, Sommacal, Sergio, Olivieri, Nunzio, Parodi, Franco, Todaro, Daniele Santo, Grassivaro, Nicoletta, Farina, Alberto, Mondino, Margaret Mary, Filippi, Massimo, and Trojano, Maria

Published
2023
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50. Hydroxyurea Pharmacokinetic Evaluation in Patients with Sickle Cell Disease

Author

Daniela Di Grazia, Cristina Mirabella, Francesco Chiara, Maura Caudana, Francesco Maximillian Anthony Shelton Agar, Marina Zanatta, Sarah Allegra, Jenni Bertello, Vincenzo Voi, Giovanni Battista Ferrero, Giuliana Abbadessa, and Silvia De Francia

Subjects
therapeutic drug monitoring, variability, maximum tolerated dose, area under the curve, high-pressure liquid chromatography, sex, Medicine, Pharmacy and materia medica, RS1-441
Abstract

Background: Hydroxyurea (HU), also known as hydroxycarbamide, is an oral ribonucleotide reductase inhibitor. In 1999, the United States Food and Drug Administration (FDA) approved HU for the treatment of sickle cell disease (SCD). Since then, it has become the cornerstone in the management of SCD patients, helping to reduce vaso-occlusive crises, acute chest syndrome, the need for blood transfusions, hospitalizations and mortality. There is considerable variability among individuals in HU pharmacokinetic (Pk) parameters that can influence treatment efficacy and toxicity. The objective of this work is part of a clinical study aimed at investigating HU Pk and determining the optimal sampling time to estimate the Area Under the Curve (AUC) in SCD patients. Methods: HU plasma concentration in 80 patients at various time points (2, 4, 6, 24 h) following a 48-h drug washout was quantified using High-Pressure Liquid Chromatography (HPLC) coupled with an ultraviolet (UV) detection method previously described in the literature and adapted to new conditions with partial modifications. Results: The mean HU administered dose was 19.5 ± 5.1 mg/kg (range: 7.7–37.5 mg/kg). The median AUC quantified in plasma patients was 101.3 mg/L/h (Interquartile Range (IQR): 72.5–355.9) and it was not influenced by the weight-based dose. However, there was a strong positive correlation between AUC and Body Mass Index (BMI) as well as dose per Body Surface Area (BSA). Along with a three-point approach for AUC determination present in the literature, we show results obtained from a four-point sampling strategy, which is more useful and effective for better optimizing dose escalation to the maximum tolerated dose (MTD). Moreover, we observed that most patients achieved the maximum HU plasma concentration two hours after drug administration, regardless of age differences. Conclusions: HU treatment, which represents a milestone in the treatment of SCD due to its ability to reduce disease complications and improve patients’ quality of life, requires careful monitoring to optimize the individual dose for saving potential side effects and/or adverse events.

Published
2024
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