Search

Your search keyword '"Miot, Helio Amante"' showing total 178 results
Start Over Author "Miot, Helio Amante"
178 results on '"Miot, Helio Amante"'

15. Zoonotic Sporotrichosis outbreak: Emerging public health threat in the Amazon State, Brazil.

Author

Mesquita, Viviany Araujo, Talhari, Sinesio, Leturiondo, André Luiz, de Souza, Guilherme Caldas, de Brito, Euzenio Moreira, de Andrade, Suanni Lemos, Fernandes, Débora Cristina de Lima, Frota, Maria Zeli Moreira, Cruz, Rossilene Conceição da Silva, Guimarães, Juliana de Andrade Rebouças, Miot, Helio Amante, Talhari, Carolina, and Pedrosa, Valderiza Lourenço

Subjects
SPOROTRICHOSIS, CAT diseases, PARACOCCIDIOIDOMYCOSIS, CENTRAL business districts, MEDICAL personnel, PUBLIC health, SYMPTOMS
Abstract

Background: Sporotrichosis is the most common subcutaneous mycosis caused by Sporothrix spp. Traditionally, it is transmitted through injuries involving plant debris. However, over the past few decades, there has been an epidemic increase in human cases resulting from contact with infected animals, particularly cats, in various regions of Brazil. In this report, we report a notable increase in both human and animal cases within the Brazilian Amazon state. Methodology/Principal findings: An ecological study was conducted by analyzing official records of human and animal sporotrichosis diagnosed in the state of Amazon from 2020 to 2023. Data including patient demographics, clinical manifestations, mycological examination results, and species identification through PCR confirmation were evaluated. During this period, a total of 950 human cases and 2,823 animal cases of sporotrichosis were reported at an exponential rate, since no human cases were registered in 2020. The spatial and temporal dispersion of human sporotrichosis followed that of animal cases, moving from downtown areas to the periphery. Contact with infected animals was reported in 77.7% of cases, with cats being the most commonly implicated (73.5%). Only 66.7% of individuals underwent mycological examination. Among the positive cultures for Sporothrix spp., 65.4% were identified as S. brasiliensis. All patients were treated with systemic antifungals. Conclusions/Significance: This study highlights a rising incidence of sporotrichosis among animals and humans in the Brazilian Amazon region over the past four years, with S. brasiliensis being the predominant agent. Collaborative efforts involving healthcare professionals, veterinarians, and public health authorities are crucial to implement effective control measures, educate populations at risk, and promote responsible guidance for pet guardians. These measures are essential to mitigate the burden of epidemic sporotrichosis in Brazil. Author summary: Sporotrichosis is the leading subcutaneous mycosis worldwide. In the last decades, Brazil has faced an epidemic of zoonotic cases. The Brazilian Amazon region had no human cases reported in 2020, nevertheless, a striking rise in both human and animal cases was observed from 2020 to 2023, totalizing 950 human and 2,823 animal sporotrichosis. The majority of cases were reported in Manaus, the largest city in the Amazon, but cases were also documented in other populous municipalities. The study emphasizes the correlation between animal and human cases, as well as the spatial and temporal progression of the disease, moving from downtown areas to the periphery. Cats were identified as the primary reservoirs, with contact with infected animals being a significant risk factor for transmission. Urban areas, particularly domestic environments, were identified as common sites of infection. The predominant species identified was Sporothrix brasiliensis, which exhibits distinct characteristics favoring zoonotic transmission. This study emphasizes the urgent need for collaborative efforts among healthcare professionals, veterinarians, and public health authorities to implement effective control measures and mitigate the impact of the epidemic sporotrichosis in Brazil. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

29. Leg Ulcers and Lymphedema

Author

Abbade, Luciana Patrícia Fernandes, Miot, Hélio Amante, Bonamigo, Renan Rangel, editor, and Dornelles, Sergio Ivan Torres, editor

Published
2018
Full Text
View/download PDF

33. Cosmetic Approach for Melasma

Author

Handel, Ana Carolina, Miot, Luciane Donida Bartoli, Miot, Hélio Amante, Issa, Maria Claudia Almeida, Series editor, and Tamura, Bhertha, Series editor

Published
2017
Full Text
View/download PDF

36. Refractory pyoderma gangrenosum associated with rheumatoid arthritis successfully treated with upadacitinib. Comments on: "JAK inhibitors: a novel, safe, and efficacious therapy for pyoderma gangrenosum".

Author

dos Santos, Mayra Rabelo, Ianhez, Mayra, Ribeiro, Bruno Nazeozeno, de Queiroz, Boaventura Braz, and Miot, Helio Amante

Subjects
RHEUMATOID arthritis, TREATMENT effectiveness, INFLAMMATORY bowel diseases, PYODERMA gangrenosum, REFRACTORY materials
Abstract

Refractory pyoderma gangrenosum associated with rheumatoid arthritis successfully treated with upadacitinib. A significant number of cytokines rely on JAK1 and JAK2, while the dependency of cytokines on JAK3 is more limited.[6] IL-6 activates intracellular signaling pathways primarily involving JAK1 and STAT3. The successful treatment of these patients with JAK inhibitors suggests the interference on the inflammatory signaling mediated by IL-6. [Extracted from the article]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results