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315 results on '"Minutoli, L."'

12. Adrenal Gland Changes in Relation to the Cause of Death

Author

Mondello, C, Ventura Spagnolo, E, Minutoli, L, Puzzolo, D, Macaione, V, Malta, C, Rinaldi, M, and Micali, A

Subjects
Medicolegal Autopsy, Adrenal Gland, Adrenal Gland, Medicolegal Autopsy, Immunohistochemistry, Immunohistochemistry
Published
2018

17. Effects of polydeoxyribonucleotide on the histological damage and the altered spermatogenesis induced by testicular ischaemia and reperfusion in rats

Author

Minutoli, L., Antonuccio, P., Squadrito, F., Bitto, A., Nicotina, P. A., Fazzari, C., Polito, F., Marini, H., Bonvissuto, G., Arena, S., Morgia, G, Romeo, C., Caputi, A. P., and Altavilla, D.

Subjects
Male, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-1, Adenosine A2 Receptor Agonists, Nitric Oxide Synthase Type III, Leydig Cells, Immunohistochemistry, adenosine receptors, Rats, Rats, Sprague-Dawley, Random Allocation, Polydeoxyribonucleotides, testicular ischaemia, infertility, spermatogenesis, polydeoxyribonucleotide, Reperfusion Injury, Testis, Animals, RNA, Messenger, Spermatogenesis, Spermatic Cord Torsion
Abstract

The effects of polydeoxyribonucleotide (PDRN), an agonist of the A2A adenosine receptors which when activated positively influences sperm activity, were tested in an experimental testicular ischaemia/reperfusion injury model. Anaesthetized male Sprague-Dawley rats were subjected to testicular torsion-induced ischaemia, followed by reperfusion (TI/R). Immediately after detorsion, randomized animals, including SHAM, received intraperitoneal injections of: (i) vehicle (1 mL/kg 0.9% NaCl solution); (ii) PDRN (8 mg/kg); (iii) DMPX (3,7-dimethyl-1-propargilxanthine, 0.1 mg/kg); or (iv) PDRN (8 mg/kg) + DMPX (0.1 mg/kg). Animals were euthanized at 1, 7 and 30 days following reperfusion. Vascular endothelial growth factor (VEGF) expression is normally associated with adenosine A2A receptor stimulation. After treatment, VEGF mRNA/protein expression quantified by qPCR and Western blot, vascular endothelial growth factor receptor-1 (VEGFR1) and endothelial nitric oxide synthase (eNOS) mRNA measured by qPCR, VEGF and VEGFR1 assessed using immunohistochemical methods, histological staining and spermatogenic activity were all analysed. Testis ischaemia-reperfusion (TI/R) injury caused increases in VEGF mRNA and protein, VEGFR1 and eNOS mRNA, histological damage and reduced spermatogenic activity. Immunostaining showed a lower expression of VEGF in germinal epithelial cells and a strong expression of VEGFR1 in Leydig cells after TI/R. PDRN administration increased significantly VEGF message/protein, VEGFR1 and eNOS message, decreased histological damage and ameliorated spermatogenic activity. PDRN might be useful in the management of testicular torsion.

Published
2011

21. Relaxation processes in glass-forming systems

Author

Altavilla, Domenica, Galli, Giovanni, Fiumara, T., Migliardo, Federica, Minutoli, L., Polito, Francesca, Squadrito, Francesco, Bevacqua, F., and Arena, B.

Published
2008

35. Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia

Author

Giuliani, D, Mioni, C, Altavilla, D, Leone, S, Bazzani, C, Minutoli, L, Bitto, A, Cainazzo, MM, Marini, H, Zaffe, D, Botticelli, AR, Pizzala, R, Savio, M, Necchi, D, Schioth, HB, Bertolini, A, Squadrito, F, Guarini, S, Giuliani, D, Mioni, C, Altavilla, D, Leone, S, Bazzani, C, Minutoli, L, Bitto, A, Cainazzo, MM, Marini, H, Zaffe, D, Botticelli, AR, Pizzala, R, Savio, M, Necchi, D, Schioth, HB, Bertolini, A, Squadrito, F, and Guarini, S

Published
2006

40. Efficacy of genistein aglycone on some cardiovascular risk factors and homocysteine levels: A follow-up study

Author

Marini, H., primary, Bitto, A., additional, Altavilla, D., additional, Burnett, B.P., additional, Polito, F., additional, Di Stefano, V., additional, Minutoli, L., additional, Atteritano, M., additional, Levy, R.M., additional, Frisina, N., additional, Mazzaferro, S., additional, Frisina, A., additional, D'Anna, R., additional, Cancellieri, F., additional, Cannata, M.L., additional, Corrado, F., additional, Lubrano, C., additional, Marini, R., additional, Adamo, E.B., additional, and Squadrito, F., additional

Published
2010
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41. 632 EFFECTS OF SERENOA REPENS, LYOCOPENE AND SELENIUM, ON PRO-INFLAMMATORY PHENOTYPE ACTIVATION: AN “IN VITRO” AND “IN VIVO” COMPARISON STUDY

Author

Bonvissuto, G., primary, Madonia, M., additional, Minutoli, L., additional, Bitto, A., additional, Polito, F., additional, Irrera, N., additional, Altavilla, D., additional, Squadrito, F., additional, Cimino, S., additional, Lazzara, A., additional, Castelli, T., additional, Favilla, V., additional, Collura, Z., additional, Russo, M., additional, and Morgia, G., additional

Published
2010
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42. Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial

Author

Marini, H., Minutoli, L., and Polito, F.

Subjects
Osteoporosis -- Prevention, Postmenopausal women -- Health aspects, Isoflavones -- Health aspects, Health, Prevention, Health aspects
Abstract

BACKGROUND: Observational studies and small trials of short duration suggest that the isoflavone phytoestrogen genistein reduces bone loss, but the evidence is not definitive. OBJECTIVE: To assess the effects of [...]

Published
2007

49. Early metabolic, functional and histological changes in a rat ileal--augmented bladder model.

Author

Arena, S., Fazzari, C., Minutoli, L., Borruto, F. A., Russo, T., and Arena, F.

Abstract

The article discusses the results of a study that evaluated the early effects of systemic metabolic changes, renal histologic morphology and histological changes of rats' ileal patch after experimental ileocystoplasty. The study developed an animal model of female Wistar species of rats in which bladder augmentation using ileum and a sham operation were performed. It showed that the augmented group's urinary pH was higher in treated rats than in shams while the bladder calculi was formed in 28.6 percent of ileocystoplasty. It concludes that treated rats showed significant improvement of serum creatine, sign of glomerular overload and depletion.

Published
2011

50. Genistein aglycone effect on bone loss is not enhanced by supplemental calcium and vitamin D3: A dose ranging experimental study.

Author

Bitto, A., Marini, H., Burnett, B.P., Polito, F., Levy, R.M., Irrera, N., Minutoli, L., Adamo, E.B., Squadrito, F., and Altavilla, D.

Abstract

Abstract: Genistein aglycone (GEN) has a favorable effect on bone loss. We investigated the effects of GEN alone or in combination with supplemental calcium and vitamin D3 in an animal model of bone loss to evaluate if there was additional benefit. Ovariectomized (OVX) and SHAM-OVX rats were used. OVX were divided into 12 groups and randomized to receive: GEN at 27, 54, 200, 500 or 1000mg (human equivalent dose (HED)/day/ip injection alone or with calcium carbonate (Ca) (360mg/kg/day/gavages) and vitamin D3 (D3) (50IU/kg/day/gavages) or Ca/D3 without GEN or untreated for 6 weeks. SHAM-OVX were randomized into 7 groups and treated with: Ca and D3 alone or in combination with GEN (same doses as OVX), or left untreated. Bone mineral density (BMD), bone-alkaline phosphatase (b-ALP), collagen C-telopeptides (CTX), osteoprotegerin (OPG) and soluble receptor activator of NFκB ligand (sRANKL) were assessed. Femurs were excised and tested for breaking strength and histology. Uterine weight was analyzed to assess GEN''s estrogenic effects on the SHAM-OVX. The most effective dose of GEN, independent of Ca/D3 supplementation, was 54mg/day. Higher doses yielded no further improvement in bone biomarkers, histology or strength. Only 1000mg/day HED of genistein produced statistically significant changes in uterine weight of the SHAM-OVX. This study suggests that 54mg/day of GEN is the threshold dose for efficacy. In addition, supplemental calcium and vitamin D3, beyond normal dietary intake do not enhance the effects of genistein on improving measures of bone loss. This observation has implications regarding the use of calcium and vitamin D3 supplementation. [Copyright &y& Elsevier]

Published
2011
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