38 results on '"Minute, M"'
Search Results
2. REGULUS CubeSat Propulsion System: In-Orbit Operations
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Bellomo, Nicolas, Milza, Fabiana, Toson, Elena, Pavarin, Daniele, Duzzi, Matteo, Manente, Marco, Trezzolani, Fabio, Mantellato, Riccardo, Minute, M., and Scalzi, D.
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operation ,satellite ,propulsion ,REGULUS CubeSat ,in-orbit - Abstract
A robust, versatile, and cost-effective propulsion system to provide wide mobility to small satellite platforms and nanosatellite deployers. A Plug&Play propulsion system designed to be easily integrated into different satellite platforms and to match customer's requirements, with minimal customization efforts and costs. more...
- Published
- 2021
Catalog
3. Does EMLA cream application interfere with the success of venipuncture or venous cannulation? A prospective multicenter observational study
- Author
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Schreiber, S., Ronfani, L., Chiaffoni, G. P., Matarazzo, L., Minute, M., Panontin, E., Poropat, F., Germani, C., and Barbi, E.
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- 2013
- Full Text
- View/download PDF
4. G118(P) Are diagnostic-therapeutic pathways really effective?
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Pin, JN, primary, Moras, P, additional, Minute, M, additional, Scozzola, F, additional, Berto, E, additional, Giancaspro, R, additional, Crotti, P, additional, and Martelossi, S, additional
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- 2020
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5. Closure of birth centers Latisana and Gorizia | Chiusura dei punti nascita di Latisana e Gorizia
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Zuiani, C., Vergine, M., Dolcemascolo, V., Tubaro, M., Romano, G., Marcuzzi, E., Rosso, I., Bon, A., Cadel, I., Celestino, S., Spagnut, G., Lualdi, R., Vernuccio, D., Arigliani, M., Moretti, R., Ventura, G., Feltrino, M., Massaro, M., Vecchiato, K., Barbieri, F., Pavan, M., Magnolato, A., Pascolo, P., Bibalo, C., Matarazzo, L., Lega, S., Nider, S., Pellegrin, M. C., Benelli, E., Minute, M., Abate, M. V., Copertino, M., Pirrone, A., Naviglio, S., Patti, G., Rizzello, E., Poropat, F., Starc, M., Shardlow, A., Chinello, M., Bramuzzo, M., Panontin, E., Cozzi, G., Paloni, G., Dal Bo, S., Rossetto, E., Rabach, I., Serena Pastore, Crocco, S., Amaddeo, A., Elkina, I., Zuiani, C, Vergine, M, Dolcemascolo, V, Tubaro, M, Romano, G, Marcuzzi, E, Rosso, I, Bon, A, Cadel, I, Celestino, S, Spagnut, G, Lualdi, R, Vernuccio, D, Arigliani, M, Moretti, R, Ventura, G, Feltrino, M, Massaro, M, Vecchiato, K, Barbieri, F, Pavan, M, Magnolato, A, Pascolo, P, Bibalo, C, Matarazzo, Lorenza, Lega, S, Nider, S, Pellegrin, Mc, Benelli, Elisa, Minute, M, Abate, Mv, Copertino, M, Pirrone, A, Naviglio, Samuele, Patti, G, Rizzello, E, Poropat, F, Starc, M, Shardlow, A, Chinello, M, Bramuzzo, M, Panontin, E, Cozzi, G, Paloni, G, Dal Bo, S, Rossetto, E, Rabach, I, Pastore, S, Crocco, S, Amaddeo, A, and Elkina, I. more...
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pediatria ,punti nascita ,pediatria, punti nascita, friuli venezia giulia ,friuli venezia giulia - Abstract
n/a
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- 2013
6. La cogenitorialità nella relazione fra padre non affidatario e figlio adolescente, in contesti di separazione coniugale
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Calvo, Vincenzo, Minute, M, and Battistella, M.
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Coparenting ,adolescenza ,separations ,Family functionning - Published
- 2007
7. L'influenza della cogenitorialità nella relazione fra padre non affidatario e figlio adolescente, in contesti di separazione coniugale: un contributo di ricerca
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Minute, M and Calvo, Vincenzo
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- 2007
8. Does EMLA cream application interfere with the success of venipuncture or venous cannulation? A prospective multicenter observational study
- Author
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Schreiber, S., primary, Ronfani, L., additional, Chiaffoni, G. P., additional, Matarazzo, L., additional, Minute, M., additional, Panontin, E., additional, Poropat, F., additional, Germani, C., additional, and Barbi, E., additional more...
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- 2012
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- View/download PDF
9. Videogame playing as distraction technique in course of venipuncture
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Minute, M., primary, Badina, L., additional, Cont, G., additional, Montico, M., additional, Ronfani, L., additional, and Barbi, E., additional
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- 2012
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10. Closure of birth centers Latisana and Gorizia,Chiusura dei punti nascita di Latisana e Gorizia
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Zuiani, C., Vergine, M., Dolcemascolo, V., Tubaro, M., Romano, G., Marcuzzi, E., Rosso, I., Bon, A., Cadel, I., Celestino, S., Spagnut, G., Lualdi, R., Vernuccio, D., Arigliani, M., Moretti, R., Ventura, G., Feltrino, M., Massaro, M., Vecchiato, K., Barbieri, F., Matteo Pavan, Magnolato, A., Pascolo, P., Bibalo, C., Matarazzo, L., Lega, S., Nider, S., Pellegrin, M. C., Benelli, E., Minute, M., Abate, M. V., Copertino, M., Pirrone, A., Naviglio, S., Patti, G., Rizzello, E., Poropat, F., Starc, M., Shardlow, A., Chinello, M., Bramuzzo, M., Panontin, E., Cozzi, G., Paloni, G., Dal Bo, S., Rossetto, E., Rabach, I., Pastore, S., Crocco, S., Amaddeo, A., and Elkina, I. more...
11. Procedural sedation 2010: The drugs,La sedazione procedurale nel 2010: I farmaci
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Badina, L., Minute, M., and Egidio Barbi
12. Design and In-orbit Demonstration of REGULUS, an Iodine electric propulsion system
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Lorenzo Cappellini, Alessandro Barbato, Marco Manente, Nabil Souhair, Riccardo Mantellato, Mirko Magarotto, Marco Minute, Alessandro Schiavon, Fabio Trezzolani, Davide Scalzi, Elena Toson, Nicolas Bellomo, A. Selmo, Matteo Duzzi, Francesco Barato, Paola De Carlo, Fabiana Milza, Simone Di Fede, Devis Paulon, Daniele Pavarin, Bellomo N., Magarotto M., Manente M., Trezzolani F., Mantellato R., Cappellini L., Paulon D., Selmo A., Scalzi D., Minute M., Duzzi M., Barbato A., Schiavon A., Di Fede S., Souhair N., De Carlo P., Barato F., Milza F., Toson E., and Pavarin D. more...
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010302 applied physics ,Propellant ,Physics ,Iodine propellant ,business.industry ,Plume analysis ,Aerospace Engineering ,Thrust ,Propulsion ,01 natural sciences ,010305 fluids & plasmas ,Plume analysi ,Regulus ,Electrically powered spacecraft propulsion ,Space and Planetary Science ,In-orbit Demonstration ,0103 physical sciences ,CubeSat ,Specific impulse ,Electronics ,Aerospace engineering ,CubeSat propulsion ,REGULUS ,business - Abstract
REGULUS is an Iodine-based electric propulsion system. It has been designed and manufactured at the Italian company Technology for Propulsion and Innovation SpA (T4i). REGULUS integrates the Magnetically Enhanced Plasma Thruster (MEPT) and its subsystems, namely electronics, fluidic, and thermo-structural in a volume of 1.5 U. The mass envelope is 2.5 kg, including propellant. REGULUS targets CubeSat platforms larger than 6 U and CubeSat carriers. A thrust T = 0.60 mN and a specific impulse Isp = 600 s are achieved with an input power of P = 50 W; the nominal total impulse is Itot = 3000 Ns. REGULUS has been integrated on-board of the UniSat-7 satellite and its In-orbit Demonstration (IoD) is currently ongoing. The principal topics addressed in this work are: (i) design of REGULUS, (ii) comparison of the propulsive performance obtained operating the MEPT with different propellants, namely Xenon and Iodine, (iii) qualification and acceptance tests, (iv) plume analysis, (v) the IoD. more...
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- 2022
13. Sedation and analgesia in children with cerebral palsy: a narrative review
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Francesca Peri, Marta Minute, Alberto Di Mascio, Ingrid Rabach, Emanuela Aru, Egidio Barbi, Marianna Lucafò, Giorgio Cozzi, Rabach, I., Peri, F., Minute, M., Aru, E., Lucafo, M., Di Mascio, A., Cozzi, G., and Barbi, E. more...
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medicine.medical_specialty ,Sedation ,MEDLINE ,Intellectual disability ,Conscious Sedation ,Pain ,Cochrane Library ,Cerebral palsy ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Pediatric surgery ,medicine ,Humans ,Pain Management ,030212 general & internal medicine ,Child ,Pain Measurement ,business.industry ,Cerebral Palsy ,Procedural sedation ,medicine.disease ,Analgesia ,Pediatrics, Perinatology and Child Health ,Physical therapy ,Anxiety ,Narrative review ,medicine.symptom ,business - Abstract
Background: Patients with cognitive impairment due to cerebral palsy experience pain more often than healthy peers and frequently require diagnostic and therapeutic painful procedures. Analgesia and procedural sedation outside the operating room are often required, but they may not adequately be provided because of the inability to accurately recognize and classify the state of pain and for the perceived higher risk of complications. Data sources: We reviewed the available literature to highlight the specific risk factors and area of criticism, that should be further improved. We searched the Cochrane Library, Medline, Pubmed from 1987 to September 2018 using key words such as ‘cerebral palsy and children and pain’ or ‘sedation and cerebral palsy and children’. Results: While different pain scales are useful in recognizing pain expressions, anxiety scales are not available. Moreover, studies on non-pharmacological techniques do not always have comparable results. Several risk factors, from anatomic abnormalities to liver and kidney functioning, should be kept in mind before proceeding with sedation. Conclusions: Large trials are needed to assess the impact of non-pharmacological techniques and to evaluate which pain control strategy (pharmacological and non-pharmacological) should be used in different settings. more...
- Published
- 2019
14. Galinstan Thermometer Is More Accurate Than Digital for the Measurement of Body Temperature in Children
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Marina Duranti, Silvana Schreiber, Luca Ronfani, Marta Minute, Gianluca Tornese, Egidio Barbi, Rita Giorgi, Schreiber, S, Minute, M, Tornese, Gianluca, Giorgi, R, Duranti, M, Ronfani, L, and Barbi, E. more...
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Male ,Adolescent ,Fever ,Thermometers ,chemistry.chemical_element ,Sensitivity and Specificity ,Body Temperature ,Mercury thermometers ,chemistry.chemical_compound ,Predictive Value of Tests ,Metals, Heavy ,Alloys ,Humans ,Medicine ,Prospective Studies ,Child ,Reference standards ,Digital thermometers ,business.industry ,Infant ,Mercury ,General Medicine ,Hospitals, Pediatric ,Mercury (element) ,Galinstan ,Italy ,chemistry ,Child, Preschool ,Thermometer ,Axilla ,Pediatrics, Perinatology and Child Health ,Emergency Medicine ,Female ,Emergency Service, Hospital ,business ,Nuclear medicine - Abstract
BACKGROUND: The mercury thermometer (MT) was considered the reference standard for the evaluation of body temperature; however, since April 2009, it has no longer been available in Italy. OBJECTIVE: This study aimed to evaluate the accuracy of digital thermometer (DT) and galinstan thermometer (GT) in comparison with the MT. METHODS: We prospectively recruited 284 children (age, 1 month to 17 years; mean, 8.5 years) seen in the emergency department of a tertiary pediatric hospital between November and December 2010. For each patient, body temperature was measured sequentially in the right axilla in a randomized fashion using DT, GT, and MT. Fever was defined as an axillary temperature of 37.5°C or greater. The temperature readings with DT and GT were compared statistically with those of MT (reference standard). RESULTS: No statistically significant difference in mean temperature was found between MT and GT in pairwise comparison (P = 0.06), whereas significant differences were found between MT and DT (P < 0.001) and between GT and DT (P < 0.001). Sensitivity and specificity of DT were 67.5% and 98.0%, respectively. When considering children with a temperature of 39°C or higher, the false-negative rate was 65.4% with DT and 30.8% with GT. CONCLUSIONS: Although both DT and GT had good specificity and positive predictive value compared with MT, GT had higher sensitivity and a lower rate of false-negative rates. Galinstan thermometer is more accurate in the measurement of body temperature compared with DT or MT. more...
- Published
- 2013
- Full Text
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15. Experience from a single paediatric transplant centre with identification of some protective and risk factors concerning the development of hepatic veno-occlusive disease in children after allogeneic hematopoietic stem cell transplant
- Author
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Massimo Gregori, Antonio Pizzol, Valentina Kiren, Paolo Tamaro, Giovanna Ferrara, Marta Minute, Marcella Montico, Natalia Maximova, Maximova, N, Ferrara, G, Minute, M, Pizzol, A, Kiren, V, Montico, M, Gregori, M, and Tamaro, Paolo more...
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hepatic veno-occlusive disease ,allogeneic hematopoietic stem cell transplant ,Male ,medicine.medical_specialty ,Hepatic veno-occlusive disease ,Adolescent ,medicine.medical_treatment ,Population ,Hepatic Veno-Occlusive Disease ,Hematopoietic stem cell transplantation ,Disease ,Defibrotide ,Sepsis ,Young Adult ,Risk Factors ,Internal medicine ,medicine ,Humans ,Transplantation, Homologous ,Mortality ,education ,Child ,Retrospective Studies ,education.field_of_study ,business.industry ,Mortality rate ,Hematopoietic Stem Cell Transplantation ,Infant, Newborn ,Infant ,Hematology ,medicine.disease ,Tacrolimus ,Surgery ,surgical procedures, operative ,Child, Preschool ,Female ,business ,medicine.drug - Abstract
Hepatic veno-occlusive disease (VOD) is a frequent and severe complication of hematopoietic stem cell transplantation (HSCT) affecting 9.6–17.3 % of cases. 200 HSCT, performed between January 1995 and March 2013 in our Paediatric HSCT Centre in Trieste, were retrospectively analysed to evaluate the frequency of VOD and to identify the associated risk factors. The frequency of VOD according to the Seattle criteria was 17 %, within the range reported in literature. The mortality rate was 37.5 % (75 out of 200 transplantations) in the general population and 73.5 % (25 out of 34) in VOD patients (p more...
- Published
- 2014
16. Does EMLA cream application interfere with the success of venipuncture or venous cannulation? A prospective multicenter observational study
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Lorenza Matarazzo, Federico Poropat, E. Panontin, Silvana Schreiber, Luca Ronfani, Marta Minute, G. P. Chiaffoni, Claudio Germani, Egidio Barbi, Schreiber, S., Ronfani, L., Chiaffoni, G. P., Matarazzo, L., Minute, M., Panontin, Elisa, Poropat, F., Germani, C., and Barbi, E. more...
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Male ,medicine.medical_specialty ,Lidocaine ,Venous cannulation ,Pediatrics ,Topical anesthetic ,Prilocaine ,Ointments ,Phlebotomy ,EMLA ,Catheterization, Peripheral ,medicine ,Humans ,Prospective Studies ,Anesthetics, Local ,Prospective cohort study ,Child ,Lidocaine, Prilocaine Drug Combination ,Venipuncture ,business.industry ,Perinatology and Child Health ,Surgery ,Logistic Models ,Vasoconstriction ,Anesthesia ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Observational study ,Female ,business ,medicine.drug - Abstract
Venipuncture and intravenous cannulation are the most common painful procedures performed on children. The most widely used topical anesthetic is eutectic mixture of local anesthetics (EMLA). EMLA use is associated with a transient cutaneous vasoconstriction which can make it difficult to identify veins. We assessed with a prospective, multicenter, observational study whether EMLA interferes with venipuncture and intravenous cannulation. The primary study outcome was a success at first attempt in the course of venipuncture or venous cannulation. The study enrolled 388 children; 255 of them received EMLA and 133 did not. Eighty-six percent of procedures were successful at the first attempt in the EMLA group and 76.7 % in the no EMLA group. Conclusion: In this study, EMLA use did not interfere with the success of venipuncture or venous cannulation in children. more...
- Published
- 2013
17. Under pressure
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Irene Berti, Angela De Cunto, Giorgio Longo, Marta Minute, De Cunto, A, Berti, I, Minute, M, and Longo, Giorgio
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Male ,medicine.medical_specialty ,integumentary system ,Urticaria ,business.industry ,food and beverages ,Delayed dermographism ,medicine.disease ,Dermatology ,urticaria ,immune system diseases ,parasitic diseases ,Pediatrics, Perinatology and Child Health ,medicine ,Pressure ,Humans ,Pressure urticaria ,Physical urticaria ,skin and connective tissue diseases ,business ,Child ,Chronic urticaria - Abstract
Physical urticaria is a rare but challenging subset of chronic urticaria. Wheals of pressure urticaria are typically delayed in appearance. A pressure test can easily be done to confirm the diagnosis. more...
- Published
- 2012
18. Videogame playing as distraction technique in course of venipuncture
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Laura Badina, Alessandro Ventura, Gabriele Cont, Luca Ronfani, Marta Minute, Marcella Montico, Egidio Barbi, Minute, M, Badina, Laura, Cont, G, Montico, M, Ronfani, L, Barbi, E, and Ventura, Alessandro more...
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Male ,medicine.medical_specialty ,Videogame ,lcsh:Surgery ,Pain ,pain control ,venipuncture ,law.invention ,Phlebotomy ,children ,Randomized controlled trial ,Interquartile range ,law ,medicine ,Humans ,Prospective Studies ,Videogame playing distraction ,Anesthetics, Local ,Child ,Prospective cohort study ,Lidocaine, Prilocaine Drug Combination ,Venipuncture ,business.industry ,technique venipuncture ,lcsh:RJ1-570 ,Lidocaine ,lcsh:Pediatrics ,lcsh:RD1-811 ,Prilocaine ,Distress ,Video Games ,Child, Preschool ,Anesthesia ,Pediatrics, Perinatology and Child Health ,FLACC scale ,Physical therapy ,Anxiety ,Female ,Surgery ,Premedication ,medicine.symptom ,business - Abstract
Background: needle-related procedures (venipuncture, intravenous cannulation) are the most common source of pain and distress for children. reducing needle related pain and anxiety could be important in order to prevent further distress, especially for children needing multiple hospital admissions. the aim of the present open randomized controlled trial was to investigate the efficacy of adding an active distraction strategy (videogame) to eMlA premedication in needle-related pain in children. Methods: one-hundred and nine children (4 -10 years of age) were prospectively recruited to enter in the study. ninety-seven were randomized in two groups: CC group (conventional care: eMlA only) as control group and Ad group (active distraction: eMlA plus videogame) as intervention group. outcome measures were: selfreported pain by mean of FPS-r scale (main study outcome), observer-reported pain by FlACC scale, number of attempts for successful procedure. Results: in both groups FPS-r median rate was 0 (interquartile range: 0-2), with significant pain (FPS-r>4) reported by 9% of subjects. FlACC median rate was 1 in both groups (interquartile range 0-3 in CC group; 0-2 in Ad group). the percentage of children with major pain (FlACC>4) was 18% in CC group and 9% in Ad group (p=0.2). the median of necessary attempts to succeed in the procedures was 1 (interquartile range 1-2) in both groups.. Conclusion: Active distraction doesn’t improve eMlA analgesia for iv cannulation and venipuncture. even though, it resulted in an easily applicable strategy appreciated by children. this technique could be usefully investigated in other painful procedures. more...
- Published
- 2012
19. Increase of pyogenic bacterial infections after relaxation of social distancing measures linked to COVID-19 pandemic.
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Rossetti V, Amaddeo A, Vanz D, Boscarelli A, Minute M, and Cozzi G
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- Humans, Retrospective Studies, Child, Male, Female, Child, Preschool, Adolescent, Physical Distancing, Italy epidemiology, Infant, Bacterial Infections epidemiology, COVID-19 epidemiology
- Abstract
Aim: After the relaxation of COVID-19 mitigation measures, we observed a dramatic increase in pyogenic infections. Based on this observation, we retrospectively analysed all cases of invasive bacterial infections of brain, lung and complicated ear-nose-throat (ENT) infections, in the period from 1 August to 31 March from the years 2018-2019 to 2022-2023., Methods: The study was conducted in two Paediatric Emergency Departments, at IRCCS 'Burlo Garofolo' of Trieste and at Treviso Hospital. Electronic medical records were searched for all cases with a definitive diagnosis at discharge of mastoiditis, suppurative cervical lymphadenitis, retropharyngeal, parapharyngeal and peritonsillar abscess (ENT group), bacterial brain abscesses, epidural empyema, subdural empyema (central nervous system group), thoracic empyema and necrotising pneumonia (lung group)., Results: In 2022-2023, we observed an increase in infections compared to the previous years. Total number of cases were 22, 29, 8, 27 and 63 in 2018-2019, 2019-2020, 2020-2021, 2021-2022 and 2022-2023, respectively. The greater increase occurred in thoracic empyema, with a peak incidence of +120% in 2022-2023 in respect of 2021-2022., Conclusion: We reported an important increase in paediatric bacterial complicated infections in two North East Italian regions, possibly correlated with the relaxation of COVID-19 social distancing measures., (© 2024 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.) more...
- Published
- 2024
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20. Implementation of the WHO standards to assess quality of care for children with acute pain in EDs: findings of a multicentre study (CHOICE) in Italy.
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Balestra E, Cozzi G, Sforzi I, Liguoro I, Felici E, Fasoli S, Bressan S, Minute M, Portale L, Dalena P, Lubrano R, Troisi A, Valentino K, Casciana ML, Ferro B, Bloise S, Marchetti F, Baltag V, Barbi E, and Lazzerini M more...
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- Humans, Italy epidemiology, Child, Male, Female, Child, Preschool, Adolescent, Infant, Quality of Health Care standards, Pain Management standards, Pain Management methods, Pain Management statistics & numerical data, Pain Measurement standards, Emergency Service, Hospital standards, Emergency Service, Hospital statistics & numerical data, World Health Organization, Acute Pain therapy, Acute Pain diagnosis
- Abstract
Background: There is little experience on the use of the WHO Standards for improving the quality of care (QOC) for children. We describe the use of four prioritised WHO Standard-based Quality Measures to assess the provision of care for children with pain in emergency departments (EDs)., Methods: In a multicentre observational study in 10 EDs with different characteristics in Italy, we collected data on 3355 children accessing the EDs between January 2019 and December 2020. The association between children and facility characteristics and quality measures was analysed through multivariate analyses., Results: The proportion of children whose pain was measured was 68.7% (n=2305), with extreme variations across different centres (from 0.0% to 99.8%, p<0.001). The proportion of children treated for pain was 28.9% (n=970) again with a wide range (5.3%-56.3%, p<0.001). The difference between the frequency of children with pain measured and pain treated varied widely between the facilities (ranging from -24.3 to 82). Children with moderate and severe pain were more frequently treated (48.9% and 62.9% of cases, respectively), although with large variations across centres (ranges: 0%-74.8% and 0%-100% respectively, p<0.001). After correction for children's characteristics, the variable more strongly associated with analysed outcomes was the facility which the child accessed for care. Being a facility in Northern Italy was associated with a higher rate of pain measurement (67.3%-95% CI: 39.9% to 94.6%, p<0.001) compared with facilities in South Italy (-22.1% lower (95% CI: -41.7% to -2.50%, p=0.03)., Conclusions: The use of few WHO Standard-based measures related to pain can help identifying priority gaps in QOC for children and in monitoring it over time. There is a need for more implementation research to establish which are the most sustainable and effective interventions to improve the QOC for acute pain in children., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.) more...
- Published
- 2024
- Full Text
- View/download PDF
21. Increased bronchiolitis burden and severity after the pandemic: a national multicentric study.
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Ghirardo S, Ullmann N, Zago A, Ghezzi M, Minute M, Madini B, D'Auria E, Basile C, Castelletti F, Chironi F, Capodiferro A, Andrenacci B, Risso FM, Aversa S, Dotta L, Coretti A, Vittucci AC, Badolato R, Amaddeo A, Barbi E, and Cutrera R more...
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- Infant, Humans, Pandemics, Retrospective Studies, Hospitalization, Coinfection epidemiology, Bronchiolitis epidemiology, Bronchiolitis therapy, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus Infections therapy
- Abstract
Background: The coronavirus 2019 (COVID-19) related containment measures led to the disruption of all virus distribution. Bronchiolitis-related hospitalizations shrank during 2020-2021, rebounding to pre-pandemic numbers the following year. This study aims to describe the trend in bronchiolitis-related hospitalization this year, focusing on severity and viral epidemiology., Methods: We conducted a retrospective investigation collecting clinical records data from all infants hospitalized for bronchiolitis during winter (1st September-31th March) from September 2018 to March 2023 in six Italian hospitals. No trial registration was necessary according to authorization no.9/2014 of the Italian law., Results: Nine hundred fifty-three infants were hospitalized for bronchiolitis this last winter, 563 in 2021-2022, 34 in 2020-2021, 395 in 2019-2020 and 483 in 2018-2019. The mean length of stay was significantly longer this year compared to all previous years (mean 7.2 ± 6 days in 2022-2023), compared to 5.7 ± 4 in 2021-2022, 5.3 ± 4 in 2020-2021, 6.4 ± 5 in 2019-2020 and 5.5 ± 4 in 2018-2019 (p < 0.001), respectively. More patients required mechanical ventilation this winter 38 (4%), compared to 6 (1%) in 2021-2022, 0 in 2020-2021, 11 (2%) in 2019-2020 and 6 (1%) in 2018-2019 (p < 0.05), respectively. High-flow nasal cannula and non-invasive respiratory supports were statistically more common last winter (p = 0.001 or less). RSV prevalence and distribution did not differ this winter, but coinfections were more prevalent 307 (42%), 138 (31%) in 2021-2022, 1 (33%) in 2020-2021, 68 (23%) in 2019-2020, 61 (28%) in 2018-2019 (p = 0.001)., Conclusions: This study shows a growth of nearly 70% in hospitalisations for bronchiolitis, and an increase in invasive respiratory support and coinfections, suggesting a more severe disease course this winter compared to the last five years., (© 2024. The Author(s).) more...
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- 2024
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22. SARS-CoV-2-related bronchiolitis: a multicentre international study.
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Cozzi G, Sovtic A, Garelli D, Krivec U, Silvagni D, Corsini I, Colombo M, Giangreco M, Giannattasio A, Milani GP, Minute M, Marchetti F, Gatto A, Debbia C, Gortan AJ, Massaro M, Hatziagorou E, Ravidà D, Diamand R, Jones E, Visekruna J, Zago A, Barbi E, Amaddeo A, and Cortellazzo Wiel L more...
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- Infant, Child, Humans, SARS-CoV-2, Retrospective Studies, Hospitalization, COVID-19 complications, COVID-19 epidemiology, Bronchiolitis diagnosis, Bronchiolitis epidemiology, Bronchiolitis therapy
- Abstract
Background: Bronchiolitis is the main acute lower respiratory tract infection in infants. Data regarding SARS-CoV-2-related bronchiolitis are limited., Objective: To describe the main clinical characteristics of infants with SARS-CoV-2-related bronchiolitis in comparison with infants with bronchiolitis associated with other viruses., Setting, Patients, Interventions: A multicentre retrospective study was conducted in 22 paediatric emergency departments (PED) in Europe and Israel. Infants diagnosed with bronchiolitis, who had a test for SARS-CoV-2 and were kept in clinical observation in the PED or admitted to hospital from 1 May 2021 to 28 February 2022 were considered eligible for participation. Demographic and clinical data, diagnostic tests, treatments and outcomes were collected., Main Outcome Measures: The main outcome was the need for respiratory support in infants testing positive for SARS-CoV-2 compared with infants testing negative., Results: 2004 infants with bronchiolitis were enrolled. Of these, 95 (4.7%) tested positive for SARS-CoV-2. Median age, gender, weight, history of prematurity and presence of comorbidities did not differ between the SARS-CoV-2-positive and SARS-CoV-2-negative infants. Human metapneumovirus and respiratory syncytial virus were the viruses most frequently detected in the group of infants negative for SARS-CoV-2.Infants testing positive for SARS-CoV-2 received oxygen supplementation less frequently compared with SARS-CoV-2-negative patients, 37 (39%) vs 1076 (56.4%), p=0.001, OR 0.49 (95% CI 0.32 to 0.75). They received less ventilatory support: 12 (12.6%) high flow nasal cannulae vs 468 (24.5%), p=0.01; 1 (1.0%) continuous positive airway pressure vs 125 (6.6%), p=0.03, OR 0.48 (95% CI 0.27 to 0.85)., Conclusions: SARS-CoV-2 rarely causes bronchiolitis in infants. SARS-CoV-2-related bronchiolitis mostly has a mild clinical course., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.) more...
- Published
- 2023
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23. Prevalence of SARS-CoV-2 positivity in infants with bronchiolitis: a multicentre international study.
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Cozzi G, Cortellazzo Wiel L, Amaddeo A, Gatto A, Giangreco M, Klein-Kremer A, Bosis S, Silvagni D, Debbia C, Nanni L, Chiappa S, Minute M, Corsini I, Morabito G, Gortan AJ, Colombo M, Marchetti F, Garelli D, Piffer A, Cardinale F, Levy N, Curatola A, Gojsina B, Basu S, Barbi E, and Sovtic A more...
- Abstract
Background: Bronchiolitis is the leading acute respiratory tract infection in infants during the winter season. Since the beginning of the SARS-CoV-2 pandemic, a reduction in the number of bronchiolitis diagnoses has been registered., Objective: The present study aimed to describe the incidence and clinical features of bronchiolitis during the 2020-2021 winter season in a large cohort of children in Europe and Israel, and to clarify the role of SARS-CoV-2., Setting, Patients, Interventions: We conducted a multicentre observational cross-sectional study in 23 paediatric emergency departments in Europe and Israel. Clinical and demographic data about all the cases of infants diagnosed with bronchiolitis from 1 October 2020 to 30 April 2021 were collected. For each enrolled patient, diagnostic tests, treatments and outcomes were reported., Main Outcome Measures: The main outcome was the prevalence of SARS-CoV-2-positive bronchiolitis., Results: Three hundred and fourteen infants received a diagnosis of bronchiolitis during the study period. Among 535 infants who tested positive for SARS-CoV-2, 16 (3%) had bronchiolitis. Median age, male sex predominance, weight, history of prematurity and presence of comorbidities did not differ between the SARS-CoV-2-positive and SARS-CoV-2-negative groups. Rhinovirus was the most common involved pathogen, while respiratory syncytial virus (RSV) was detected in one case. SARS-CoV-2 bronchiolitis had a mild clinical course, with one patient receiving oxygen supplementation and none requiring paediatric or neonatal intensive care unit admission., Conclusions: During the SARS-CoV-2 pandemic, a marked decrease in the number of bronchiolitis diagnoses and the disappearance of the RSV winter epidemic were observed. SARS-CoV-2-related bronchiolitis was rare and mostly displayed a mild clinical course., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.) more...
- Published
- 2022
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24. Distraction Using Buzzy or Handheld Computers During Venipuncture.
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Cozzi G, Crevatin F, Dri V, Bertossa G, Rizzitelli P, Matassi D, Minute M, Ronfani L, and Barbi E
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- Child, Computers, Handheld, Humans, Pain etiology, Pain prevention & control, Prospective Studies, Pain Management, Phlebotomy adverse effects
- Abstract
Objectives: Venipuncture is one of the most frequently performed painful procedures in children. The aim of this study was to investigate the effectiveness of 2 analgesic strategies for venipuncture in children in a specific setting like a blood-drawing center., Methods: This was a prospective randomized controlled trial. It was conducted in the blood-drawing center of a tertiary level children's hospital in Italy, between November 2014 and February 2015. Eligible patients were children aged from 4 to 12 years referred to the blood-drawing center for venipuncture. Enrolled children were randomized to be distracted by Buzzy device or by playing with a handheld computer. The procedural pain was measured with the faces pain scale-revised by children aged from 4 to 7 years and with a numerical rating scale by children aged from 8 to 12 years., Results: Two hundred children with a median age of 8 years were enrolled in the study. The self-reported procedural pain was not statistically different between the Buzzy group and the handheld computer group: median (interquartile range) = 3.0 (1.0-4.8) and 2.0 (1.0-4.8), respectively (P = 0.72). Children reported significant pain in 25% of cases with both distraction strategies. The procedural success rate at the first attempt was not significantly different in the 2 groups., Conclusions: Analgesia provided by Buzzy or by a handheld computer was not significantly different in children undergoing venipuncture in a blood-drawing center, with the great proportion of them reporting no or mild pain during procedure., Competing Interests: Disclosure: The authors declare no conflict of interest., (Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.) more...
- Published
- 2021
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25. Impact and Sustainability of Antibiotic Stewardship in Pediatric Emergency Departments: Why Persistence Is the Key to Success.
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Barbieri E, De Luca M, Minute M, D'Amore C, Ciofi Degli Atti ML, Martelossi S, Giaquinto C, Da Dalt L, Zaoutis T, and Dona D
- Abstract
Antibiotic stewardship programs proved to be effective in improving prescribing appropriateness. This multicenter quasi-experimental study, aimed to assesses the stewardship impact on antibiotics prescribing in different semesters from 2014 to 2019 in three pediatric emergency departments (Center A, B, and C) in Italy. All consecutive patients diagnosed with acute otitis media or pharyngitis were evaluated for inclusion. Two different stewardship were adopted: for Center A and B, clinical pathways were implemented and disseminated, and yearly lectures were held, for Center C, only pathways were implemented. Broad-spectrum prescription rates decreased significantly by 80% for pharyngitis and 29.5 to 55.2% for otitis after the implementation. In Center C, rates gradually increased from the year after the implementation. Amoxicillin dosage adjusted to pharyngitis recommendations in Center C (53.7 vs. 51.6 mg/kg/die; p = 0.011) and otitis recommendations in Center A increasing from 50.0 to 75.0 mg/kg/die ( p < 0.001). Days of therapy in children < 24 months with otitis increased from 8.0 to 10.0 in Center A, while in older children decreased in Center A (8.0 vs. 7.0; p < 0.001) and Center B (10.0 vs. 8.0; p < 0.001). Clinical pathways combined with educational lectures is a feasible and sustainable program in reducing broad-spectrum antibiotic prescribing with stable rates over time. more...
- Published
- 2020
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26. Sedation and analgesia in children with cerebral palsy: a narrative review.
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Rabach I, Peri F, Minute M, Aru E, Lucafò M, Di Mascio A, Cozzi G, and Barbi E
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- Child, Humans, Pain Measurement, Analgesia methods, Cerebral Palsy, Conscious Sedation methods, Pain Management methods
- Abstract
Background: Patients with cognitive impairment due to cerebral palsy experience pain more often than healthy peers and frequently require diagnostic and therapeutic painful procedures. Analgesia and procedural sedation outside the operating room are often required, but they may not adequately be provided because of the inability to accurately recognize and classify the state of pain and for the perceived higher risk of complications., Data Sources: We reviewed the available literature to highlight the specific risk factors and area of criticism, that should be further improved. We searched the Cochrane Library, Medline, Pubmed from 1987 to September 2018 using key words such as 'cerebral palsy and children and pain' or 'sedation and cerebral palsy and children'., Results: While different pain scales are useful in recognizing pain expressions, anxiety scales are not available. Moreover, studies on non-pharmacological techniques do not always have comparable results. Several risk factors, from anatomic abnormalities to liver and kidney functioning, should be kept in mind before proceeding with sedation., Conclusions: Large trials are needed to assess the impact of non-pharmacological techniques and to evaluate which pain control strategy (pharmacological and non-pharmacological) should be used in different settings. more...
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- 2019
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27. Impact of near infrared light in pediatric blood drawing Centre on rate of first attempt success and time of procedure.
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Conversano E, Cozzi G, Pavan M, Minute M, Gortan E, Montico M, Vecchi Brumatti L, Ronfani L, and Barbi E
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- Adolescent, Age Factors, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Time Factors, Infrared Rays, Lighting, Phlebotomy methods
- Abstract
Background: Peripheral blood access and venipuncture are a stressful and painful experience in pediatric patients; moreover, it is estimated that more than one attempt is required to achieve the procedure in about one third of children. For this reason, we investigated if Near-infrared light technology routinely used, could give an advantage to venipuncture in a pediatric blood center setting., Methods: We conducted an open, pseudo-randomized controlled trial with two parallel arms, in the blood-drawing center, with enrolment of 115 patients between 0 and 18 years, in 14 consecutive working days. Fifty-three subjects were enrolled in group 1 (VeinViewer®) and 62 in group 2 (control group). We divided patients into three subgroups considering their age (< 5 years, 6-10 years, > 10 years). The primary study outcome was to assess if the use of VeinViewer® was associated with a reduction of time to perform blood sampling. The secondary outcome was to analyze VienViewer®'s impact on first attempt success rate in blood sampling., Results: No difference was found regarding the duration of blood sampling between the two groups, even after stratifying the patients into the three age subgroups. There was no difference between the two groups in the success at the first attempt in blood sampling., Conclusions: Routine use of VeinViewer® is not useful to reduce time of the procedure during venipuncture., Trial Registration: The study was registered with ClinicalTrials.gov, with number NCT03277092 , on September 8, 2017. more...
- Published
- 2018
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28. Afebrile seizures in infants: Never forget magnesium!
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Minute M, Ventura G, Giorgi R, Faletra F, Costa P, and Cozzi G
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- Female, Humans, Hypocalcemia diagnosis, Hypocalcemia etiology, Infant, Metal Metabolism, Inborn Errors complications, Metal Metabolism, Inborn Errors genetics, Mutation, Magnesium blood, Metal Metabolism, Inborn Errors diagnosis, Seizures etiology
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- 2018
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29. Risk of hospitalisation after early-revisit in the emergency department.
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Cozzi G, Ghirardo S, Fiorese I, Proietti I, Monasta L, Minute M, Barbi E, and Calligaris L
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- Adolescent, Child, Child, Preschool, Female, Humans, Infant, Italy, Male, Retrospective Studies, Risk Assessment, Tertiary Care Centers, Time Factors, Emergency Service, Hospital, Hospitalization
- Abstract
Aim: Early-revisits are frequent in the paediatric emergency department (ED) setting, but few data are available about early-revisited patients. The aim of this study was to investigate the hospitalisation rate of a population of early-revisited patients and to detect if an early-revisited patient was at risk of a more severe disease., Methods: Between June 2014 and January 2015, we conducted a retrospective cohort study, considering all patients presented to the ED of a tertiary level children's hospital in Italy. We selected all patients who were revisited within 72 h from the initial visit (study cohort), while all other patients accessed in the same period were considered the control cohort. The two cohorts were compared for age, gender, triage category, hospitalisation rate, diagnosis at admission and hospital length of stay., Results: In the study period, we reviewed 10 750 visits, of which 430 (4%) were unplanned revisits for the same chief complaint within 72 h from the initial visit. Hospitalisation rate of early-revisited patients was significantly higher compared to control patients (8.4 vs. 2.9%). Hospitalisation rate increases in parallel with the number of revisits, but in many cases, it was not directly related to a worst triage category, neither to a longer hospital length of stay., Conclusion: Early revisited patients in the ED had a significantly higher risk of hospitalisation, but this risk was only partially related to their clinical conditions., (© 2017 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).) more...
- Published
- 2017
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30. Mental Health Problems in Children and Adolescents in the Emergency Department: "The Times They Are A-Changin'".
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Cozzi G, Minute M, Ventura G, and Barbi E
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- Adolescent, Child, Humans, Mental Health Services statistics & numerical data, Emergency Service, Hospital statistics & numerical data, Mental Disorders epidemiology, Patient Admission statistics & numerical data
- Published
- 2017
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31. Children with cancer: a survey on the experience of Italian primary care pediatricians.
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Minute M, Cozzi G, Plotti C, Montanari G, Pecile P, Zanazzo GA, Ventura A, and Barbi E
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- Child, Child, Preschool, Cross-Sectional Studies, Disease-Free Survival, Female, Humans, Italy epidemiology, Male, Needs Assessment, Neoplasms pathology, Outcome Assessment, Health Care, Practice Patterns, Physicians', Prevalence, Retrospective Studies, Risk Assessment, Survival Analysis, Neoplasms epidemiology, Neoplasms therapy, Pediatricians statistics & numerical data, Primary Health Care methods
- Abstract
Background: Cancer is the second cause of death in children and its diagnosis can be difficult, due to the presence of vague and non-specific symptoms. The primary care pediatrician is often involved in the diagnostic process, but no longer in child care once the treatment started. Care models involving both primary care pediatricians and oncologic referral centre highlighted a higher family satisfaction when they worked together. We conducted a survey on primary care pediatricians involved in childhood cancer in order to describe the actual situation., Methods: We conducted a retrospective survey enrolling primary care pediatricians from a north-eastern area of Italy. They received a questionnaire that consisted in two parts: the first one aimed to assess the physician's seniority and experience and the second one pertained to each case of cancer and explored the relationship between the pediatrician, the family and the referral centre, and pediatricians degree of satisfaction and emotional impact., Results: We obtained data from 79 pediatricians who described 150 cancer cases. In 99 cases the primary care pediatrician had visited the child at the onset of symptoms and had referred him to the hospital. In 89 cases, he understood the severity of the disease. In 53.3% of cases the pediatrician was informed by the referral centre. The relationship between the pediatrician and child's family improved in 38% of cases and this was related with their participation to the multidisciplinary meetings on child health., Conclusions: Primary pediatricians' sharing in the management of their patients with cancer was not satisfactory. Development of specific protocols targeted to an integrated care is needed to increase primary pediatricians' involvement and families' satisfactions. more...
- Published
- 2017
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32. Somatic symptom disorder was common in children and adolescents attending an emergency department complaining of pain.
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Cozzi G, Minute M, Skabar A, Pirrone A, Jaber M, Neri E, Montico M, Ventura A, and Barbi E
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- Adolescent, Child, Female, Humans, Italy epidemiology, Male, Prospective Studies, Emergency Service, Hospital statistics & numerical data, Medically Unexplained Symptoms, Pain epidemiology
- Abstract
Aim: The aim of this study was to quantify the prevalence of somatic pain in a paediatric emergency department (ED)., Methods: We conducted a prospective observational study using patients admitted to the ED of an Italian children's hospital between December 2014 and February 2015. We enrolled children aged 7-17 who turned up at the ED complaining of pain. Patients and parents were asked to fill in a questionnaire to allow the analysis of the patients' medical history and provide contact details for follow-up. We divided the enrolled patients into four groups: post-traumatic pain, organic pain, functional pain and somatic pain. The questionnaire was used to define pain characteristics and to generate an impairment score., Results: Of the 713 patients who met inclusion criteria, 306 (42.9%) were enrolled in the study. Of these, 135 (44.0%) suffered from post-traumatic pain, 104 (34.0%) from organic pain, 41 (13.4%) from functional pain and 26 (8.6%) from somatic pain. Somatic pain patients had endured pain longer, had missed more school days and had suffered severe functional impairment., Conclusion: This study highlighted that somatic pain was a significant contributor to paediatric emergency room visits and should be suspected and diagnosed in children reporting pain., (©2017 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.) more...
- Published
- 2017
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33. An adolescent with disabling abdominal pain.
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Minute M, Cozzi G, and Barbi E
- Subjects
- Adolescent, Female, Humans, Pain Measurement, Severity of Illness Index, Abdominal Pain psychology, Absenteeism, Fatigue psychology, Medically Unexplained Symptoms, Nausea psychology, Social Participation, Stress, Psychological psychology
- Published
- 2016
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34. A quasi randomized-controlled trial to evaluate the effectiveness of clowntherapy on children's anxiety and pain levels in emergency department.
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Felluga M, Rabach I, Minute M, Montico M, Giorgi R, Lonciari I, Taddio A, and Barbi E
- Subjects
- Anxiety etiology, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Male, Pain diagnosis, Pain Measurement, Prospective Studies, Surveys and Questionnaires, Treatment Outcome, Anxiety therapy, Emergency Service, Hospital, Laughter Therapy methods, Pain complications, Pain Management methods
- Abstract
Unlabelled: The aim of the study is to investigate if the presence of medical clowns during painful procedures in the emergency department (ED) affects children's anxiety and pain. Forty children (4-11 years) admitted to the ED with the need of painful procedures were prospectively enrolled. They were randomly assigned to the clown group, where children interacted with clowns or to the control group in which they were entertained by parents and ED nurses. The children's anxiety was assessed by the Children's Anxiety and Pain Scales; pain was evaluated with the Numerical Rating Scale and Wong-Backer Scale, according to the children's age. Staff and clown's opinions were evaluated by means of dedicated questionnaires. Children's anxiety levels in the clown group were significantly lower than those compared with the control group, while children's pain levels did not change between the two groups., Conclusion: The presence of clowns in the ED before and during painful procedures was effective in reducing children's anxiety., What Is Known: • Anxiety and fear caused by medical procedures exacerbate children's pain and may interfere with the procedure. • To reduce anxiety, fear, and pain and to facilitate patient's evaluation, different non-pharmacological approaches have been proposed and positive effects of laughter and humor have been reported. What is New: • The presence of clowns in the waiting room and in the ED during medical evaluation and painful procedures helps to reduce children's anxiety. more...
- Published
- 2016
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35. Sirolimus Therapy in Congenital Hyperinsulinism: A Successful Experience Beyond Infancy.
- Author
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Minute M, Patti G, Tornese G, Faleschini E, Zuiani C, and Ventura A
- Subjects
- Child, Humans, Male, Remission Induction, Congenital Hyperinsulinism drug therapy, Sirolimus therapeutic use
- Abstract
Congenital hyperinsulinism (CHI) due to diffuse involvement of the pancreas is a challenging and severe illness in children. Its treatment is based on chronic therapy with diazoxide and/or octreotide, followed by partial pancreatectomy, which is often not resolutive. Sirolimus, a mammalian target of rapamycin inhibitor, was reported to be effective in treating CHI in infants. We report here the case of an 8-year-old boy affected by a severe form of CHI due to a biallelic heterozygous ABCC8 mutation who responded to sirolimus with a dramatic improvement in his glucose blood level regulation and quality of life, with no serious adverse events after 6 months of follow-up. To the best of our knowledge, this is the first report of a successful intervention in an older child. It provides a promising basis for further studies comparing sirolimus with other treatments, particularly in older children., (Copyright © 2015 by the American Academy of Pediatrics.) more...
- Published
- 2015
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36. Under pressure.
- Author
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De Cunto A, Berti I, Minute M, and Longo G
- Subjects
- Child, Humans, Male, Urticaria diagnosis, Pressure adverse effects, Urticaria etiology
- Abstract
Physical urticaria is a rare but challenging subset of chronic urticaria. Wheals of pressure urticaria are typically delayed in appearance. A pressure test can easily be done to confirm the diagnosis. more...
- Published
- 2013
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37. Successful treatment of acne with isotretinoin in chronic granulomatous disease.
- Author
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Barbi E, Berti I, Minute M, and Zennaro F
- Subjects
- Acne Vulgaris epidemiology, Adult, Anti-Infective Agents administration & dosage, Comorbidity, Granulomatous Disease, Chronic epidemiology, Humans, Male, Trimethoprim, Sulfamethoxazole Drug Combination administration & dosage, Acne Vulgaris drug therapy, Dermatologic Agents therapeutic use, Granulomatous Disease, Chronic drug therapy, Isotretinoin therapeutic use
- Published
- 2011
- Full Text
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38. Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines.
- Author
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Lee Y, Gotoh A, Kwon HJ, You M, Kohli L, Mantel C, Cooper S, Hangoc G, Miyazawa K, Ohyashiki K, and Broxmeyer HE
- Subjects
- Bone Marrow Cells cytology, Cell Survival drug effects, Chemokine CXCL12, Chemokines, CXC physiology, Cytokines pharmacology, Cytokines physiology, Drug Synergism, Fetal Blood cytology, Hematopoietic Stem Cells drug effects, Humans, MAP Kinase Signaling System drug effects, Mitogen-Activated Protein Kinases drug effects, Myeloid Progenitor Cells cytology, Myeloid Progenitor Cells drug effects, Proto-Oncogene Proteins drug effects, Proto-Oncogene Proteins c-akt, Ribosomal Protein S6 Kinases drug effects, Tumor Cells, Cultured, Chemokines, CXC pharmacology, Hematopoietic Stem Cells cytology, Protein Serine-Threonine Kinases, Signal Transduction drug effects
- Abstract
Stromal cell-derived factor 1 (SDF-1/CXCL12) is a multifunctional cytokine. We previously reported that myelopoiesis was enhanced in SDF-1 alpha transgenic mice, probably due in part to SDF-1 alpha enhancement of myeloid progenitor cell (MPC) survival. To understand signaling pathways involved in this activity, we studied the effects on factor-dependent cell line MO7e cells incubated with SDF-1 alpha alone or in combination with other cytokines. SDF-1 alpha induced transient activation of extracellular stress-regulated kinase (ERK1/2), ribosomal S6 kinase (p90RSK) and Akt, molecules implicated in cell survival. Moreover, ERK1/2, p90RSK, and Akt were synergistically activated by SDF-1 alpha in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), Steel factor (SLF), or thrombopoietin (TPO). Similar effects were seen after pretreatment of MO7e cells with SDF-1 alpha followed by stimulation with the other cytokines, suggesting a priming effect of SDF-1 alpha. Nuclear factor-kappa B (NF-kappa B) did not appear to be involved in SDF-1 alpha actions, alone or in combination with other cytokines. These intracellular effects were consistent with enhanced myeloid progenitor cell survival by SDF-1 alpha after delayed addition of growth factors. SDF-1 alpha alone supported survival of highly purified human cord blood CD34(+++) cells, less purified human cord blood, and MO7e cells; this effect was synergistically enhanced when SDF-1 alpha was combined with low amounts of other survival-promoting cytokines (GM-CSF, SLF, TPO, and FL). SDF-1 may contribute to maintenance of MPCs in bone marrow by enhancing cell survival alone and in combination with other cytokines. more...
- Published
- 2002
- Full Text
- View/download PDF
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