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Digital Business Transformation, Digitalisation, Business Strategy, Business Process, Business Analysis, Business Architecture, Business Models Digitale Transformation, Digitalisierung, Geschäftsstrategie, Geschäftsprozess, Businessanalyse, Businessarchitektur This book serves practitioners as a guide to digital business engineering. It was consciously conceived and prepared from a methodological perspective, thereby avoiding a strongly "technological" approach, rather focusing on the presentation of methods and instruments. Its basis is a tried and tested framework model that can be understood as the ideal management cycle of digital business engineering. The control loop consists of goal-setting (Chapter 1: Setting a Business Strategy), implementation (Chapters 2–5), and success assessment (Chapter 6: Validating the Success of Business Transformation) and is located in an outer circuit. The operational implementation phases of digital business engineering are part of the inner cycle: Defining a Business Case (Chapter 2), Eliciting the Business Processes (Chapter 3), Deriving the Business Requirements (Chapter 4), and Transforming the Business Architecture (Chapter 5). The book follows a didactic structure: Each chapter includes learning objectives, summaries, and repetition questions with solutions that can help the reader to reassure themselves and strengthen their knowledge. Users who want to familiarise themselves with the field of digital business engineering thus have material at their disposal that is ideal for self-study. But these modules can also help experienced digital business engineers to deepen their knowledge in their organisation and to strengthen their overall methodological competence.

Tumor biopsy is still the gold standard for diagnosing and prognosis renal cell carcinoma (RCC). However, its invasiveness, costs, and inability to accurately picture tumor heterogeneity represent major limitations to this procedure. Analysis of circulating cell-free DNA (cfDNA) is a non-invasive cost-effective technique that has the potential to ease cancer detection and prognosis. In particular, a growing body of evidence suggests that cfDNA could be a complementary tool to identify and prognosticate RCC while providing contemporary mutational profiling of the tumor. Further, recent research highlighted the role of cfDNA methylation profiling as a novel method for cancer detection and tissue-origin identification. This review synthesizes current knowledge on the diagnostic, prognostic, and predictive applications of cfDNA in RCC, with a specific focus on the potential role of cell-free methylated DNA (cfMeDNA).

In this article, building on the work of Freud, Lacan, Judith Butler, and other researchers on the relationship between subjectivity and language, Hatem confronts us with the challenges and opportu...

In this article Thamy Ayouch discusses a psychoanalysis who aspires to sustain the voices of subaltern minorities in postcolonial society. Addressing the issue of Moroccan “homosexualities”, the au...

When a patient with chronic renal failure is told he must undergo hemodialysis, he/she lives an emotional shock, followed by a phase of anxiety. If this shock can’t be overcome, the patient can face some anxious-depressive pathologies that will complicate the already complex clinical picture. The aim of this work is to demonstrate how the communicative/educational measures are the clinical instruments, applied especially by nurses, that lead the patient to the acquisition of different skills (such as self-reliance and psycho-social abilities). In conclusion, an efficient communication, mainly based on active and participative listening, represents the most effective instrument for the patient with chronic-degenerative pathologies to promote the awareness of his own capacities of self-management, and to make him play a leading role in his own health. (narrative nephrology)

The construction industry implies significant resource demands in two contexts: The supply of primary materials, as well as the conditioning and/or disposing of the materials resulting from excavation and demolition processes. Primary materials are limited and resource intensive in procurement, as well as in distribution. Landfill on the other hand requires brownfield sites and implies the risk of inert contamination of the soil. Manufacturing, re-use and recycling of these materials are thus an important step towards a circular economy and government agencies are interested in steering these material flows. From an economic point of view, these systems can be very volatile: Prices, availabilities and process capacities are fluctuating, while the locations of the construction sites change on a monthly basis. This paper presents a new approach using a digital twin of such a system to identify effective steering inputs and assist government agencies to understand the system and predict the influence of any potential measures. Based on a reduced graph representing the transportation network of the region, statistical information about the price structure of materials and services in the region as well as the decisions of different players within the systems are modelled. Using the Monte Carlo method, different material flows are quantified based on a set of statistical location parameters. The application of this model in the identification of steering inputs, as well as in the evaluation of potential scenarios is successfully demonstrated on two practical examples., + ID der Publikation: hslu_83698 + Art des Beitrages: Wissenschaftliche Medien + Sprache: Englisch + Letzte Aktualisierung: 2021-06-07 16:26:20

This article deals with the topic of the «Business to Business (B2B) Sharing Economy». The concept of «sharing» has become increasingly popular in recent years and the aspect of environmental protection, in particular, is often mentioned as a reason for this, as well as lower prices for consumers. It is, therefore, understandable that start-ups with new business models in this aream are becoming increasingly more prevalent. Their business is mainly concentrated in the consumer goods industry. But what about the so-called B2B context? This is associated with sharing resources, such as machinery, personnel or infrastructure between companies. An essential component of this change is industrial digital sharing platforms, which provide the services necessary to make the networking of the various actors in the business ecosystem, more effective and efficient., + ID der Publikation: hslu_82837 + Art des Beitrages: Wissenschaftliche Medien + Jahrgang: 01/20 + Sprache: Englisch + Letzte Aktualisierung: 2021-03-23 14:46:19

Cutaneotrichosporon oleaginosus is an oleaginous yeast with several favourable qualities: It is fast growing, accumulates high amounts of lipids and has a very broad substrate spectrum. Its resistance to hydrolysis by-products makes it a promising biocatalyst for custom tailored microbial oils. C. oleaginosus can accumulate up to 60 wt.% of its biomass as lipids. This species is able to grow by using several compounds as a substrate, such as acetic acid, biodiesel-derived glycerol, N-acetylglucosamine, lignocellulosic hydrolysates, wastepaper and other agro-industrial wastes. This review is focused on state-of-the-art innovative and sustainable biorefinery schemes involving this promising yeast and second- and third-generation biomasses. Moreover, this review offers a comprehensive and updated summary of process strategies, biomass pretreatments and fermentation conditions for enhancing lipid production by C. oleaginosus as a whole-cell biocatalyst. Finally, an overview of the main industrial applications of single-cell oil is reported together with future perspectives.