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effects of high dietary phosphate on dental caries,’0 a group of children became available who presumably had been receiving diets high in calcium and phosphorus for periods of from one to two years. The present report is concerned with the effects of these diets on metabolic balances of minerals and nitrogen in eighteen children from this study. EXPERIMENTAL METHODS

SummaryCarbutamide, a sulfonylurea compound capable of lowering blood sugar, did not have an insulin-like action in increasing glycogen deposition of isolated rat hemi-diaphragm. Furthermore, this drug did not produce any enhancement of the insulin effect. In fact, when higher concentrations were used there was a significant inhibition of the insulin effect. This inhibition is somewhat non-specific since it was also observed when sulfadiazine was substituted for Carbutamide. It is suggested that this inhibition, the inhibition of insulinase, and the in vitro reduction of the epinephrine and glucagon response which have been attributed to the sulfonylurea compounds might all be due to a non-specific protein poisoning action of these drugs in higher concentrations.

Excerpt In vivo studies have shown bile salts influence not only intestinal absorption of sterols but also intestinal synthesis of sterols. We assayed scrapings of guinea pig small-intestine mucosa...