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117 results on '"Minners J"'

1. Comparison of various tools for diagnosis of an atrial cardiomyopathy for outcome prediction after pulmonary vein isolation in patients with persistent atrial fibrillation - What is the Holy Grail?

Author

Eichenlaub, M, primary, Lehrmann, H, additional, Minners, J, additional, Schoechlin, S, additional, Mueller-Edenborn, B, additional, Jander, N, additional, Allgeier, M, additional, Allgeier, J, additional, Bohnen, M, additional, Neumann, F J, additional, Trenk, D, additional, Westermann, D, additional, Arentz, T, additional, and Jadidi, A, additional

Published
2023
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3. Comparison of various late gadolinium enhancement magnetic resonance imaging methods to high-definition voltage and activation mapping for detection of atrial cardiomyopathy

Author

Eichenlaub, M, primary, Mueller-Edenborn, B, additional, Minners, J, additional, Hein, M, additional, Ruile, P, additional, Lehrmann, H, additional, Schoechlin, S, additional, Allgeier, J, additional, Bohnen, M, additional, Trenk, D, additional, Neumann, F-J, additional, Arentz, T, additional, and Jadidi, A, additional

Published
2022
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12. 94Course of contained annulus ruptures after TAVI: the ENCORE (European contained rupture)-registry

Author

Breitbart, P, primary, Minners, J, additional, Pache, G, additional, Hansson, N C, additional, Norgaard, B L, additional, De Backer, O, additional, Sondergaard, L, additional, Alsanjari, O, additional, Hildick-Smith, D, additional, Reinoehl, J, additional, Abdel-Wahab, M, additional, Loebig, S, additional, Neumann, F.-J, additional, and Ruile, P, additional

Published
2019
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16. Do atrial differences in endothelial damage, leukocyte and platelet activation, or tissue factor activity contribute to chamber-specific thrombogenic status in patients with atrial fibrillation?

Author

Jesel, L., Arentz, T., Herrera-Siklody, C., Trenk, D., Zobairi, F., Abbas, Micheline, Weber, R., Minners, J., Toti, F., Morel, O., Barthel, Ingrid, Laboratoire de Biophotonique et Pharmacologie - UMR 7213 (LBP), Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

19. Risk stratification in patients with acute chest pain using three high-sensitivity cardiac troponin assays

Author

Haaf, P., primary, Reichlin, T., additional, Twerenbold, R., additional, Hoeller, R., additional, Rubini Gimenez, M., additional, Zellweger, C., additional, Moehring, B., additional, Fischer, C., additional, Meller, B., additional, Wildi, K., additional, Freese, M., additional, Stelzig, C., additional, Mosimann, T., additional, Reiter, M., additional, Mueller, M., additional, Hochgruber, T., additional, Sou, S. M., additional, Murray, K., additional, Minners, J., additional, Freidank, H., additional, Osswald, S., additional, and Mueller, C., additional

Published
2013
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20. Poster Session 2: Thursday 8 December 2011, 14:00-18:00 * Location: Poster Area

Author

Luo, X., primary, Fang, F., additional, Sun, J., additional, Xie, J., additional, Lee, A., additional, Zhang, Q., additional, Yu, C., additional, Breithardt, O., additional, Schiessl, S., additional, Schmid, M., additional, Seltmann, M., additional, Klinghammer, L., additional, Zeissler, C., additional, Kuechle, M., additional, Daniel, W., additional, Ege, M., additional, Guray, U., additional, Guray, Y., additional, Demirkan, B., additional, Kisacik, H., additional, Kim, S.-E., additional, Hong, J.-Y., additional, Lee, J.-H., additional, Park, D.-G., additional, Han, K.-R., additional, Oh, D.-J., additional, Tufekcioglu, O., additional, Cozma, D. C., additional, Mornos, C., additional, Ionac, A., additional, Petrescu, L., additional, Tutuianu, C., additional, Dragulescu, S. I., additional, Guimaraes, L., additional, Tavares, G., additional, Rodrigues, A., additional, Nagamatsu, C., additional, Fischer, C., additional, Vieira, M., additional, Oliveira, W., additional, Wilberg, T., additional, Cordovil, A., additional, Morhy, S., additional, Muraru, D., additional, Peluso, M., additional, Dal Bianco, L., additional, Beraldo, M., additional, Solda', E., additional, Tuveri, M., additional, Cucchini, U., additional, Al Mamary, A., additional, Badano, L., additional, Iliceto, S., additional, Pizzuti, A., additional, Mabritto, B., additional, Derosa, C., additional, Tomasello, A., additional, Rovere, M., additional, Parrini, I., additional, Conte, M., additional, Lareva, N., additional, Govorin, A., additional, Cooper, R., additional, Sharif, J., additional, Somauroo, J. D., additional, Hung, J. D., additional, Porcelli, V., additional, Skevington, R., additional, Shahzad, A., additional, Scott, S., additional, Lindqvist, P., additional, Soderberg, S., additional, Gonzalez, M., additional, Tossavainen, E., additional, Henein, M., additional, Nciri, N., additional, Saad, H., additional, Nawas, S., additional, Ali, A., additional, Youssufzay, A., additional, Safi, A., additional, Faruk, S., additional, Yurdakul, S., additional, Erdemir, V., additional, Tayyareci, Y., additional, Yildirimturk, O., additional, Memic, K., additional, Aytekin, V., additional, Gurel, M., additional, Aytekin, S., additional, Przewlocka-Kosmala, M., additional, Cielecka-Prynda, M., additional, Mysiak, A., additional, Kosmala, W., additional, Pescariu, S., additional, Cozma, D., additional, Mornos, A., additional, Dragulescu, S., additional, Maurea, N., additional, Tocchetti, C. G., additional, Coppola, C., additional, Quintavalle, C., additional, Rea, D., additional, Barbieri, A., additional, Piscopo, G., additional, Arra, C., additional, Condorelli, G., additional, Iaffaioli, R., additional, Dalen, H., additional, Thorstensen, A., additional, Moelmen, H., additional, Torp, H., additional, Stoylen, A., additional, Augustine, D., additional, Basagiannis, C., additional, Suttie, J., additional, Cox, P., additional, Aitzaz, R., additional, Lewandowski, A., additional, Lazdam, M., additional, Holloway, C., additional, Becher, H., additional, Leeson, P., additional, Radovanovic, S., additional, Djokovic, A., additional, Todic, B., additional, Zdravkovic, M., additional, Zaja-Simic, M., additional, Banicevic, S., additional, Lisulov-Popovic, D., additional, Krotin, M., additional, Grapsa, J., additional, O'regan, D., additional, Dawson, D., additional, Durighel, G., additional, Howard, L., additional, Gibbs, J., additional, Nihoyannopoulos, P., additional, Tulunay Kaya, C., additional, Kilickap, M., additional, Kurklu, H., additional, Ozbek, N., additional, Koca, C., additional, Kozluca, V., additional, Esenboga, K., additional, Erol, C., additional, Kusmierczyk-Droszcz, B., additional, Kowalik, E., additional, Niewiadomska, J., additional, Hoffman, P., additional, Satendra, M., additional, Sargento, L., additional, Lopes, S., additional, Longo, S., additional, Lousada, N., additional, Palma Reis, R., additional, Chillo, P., additional, Rieck, A., additional, Lwakatare, J., additional, Lutale, J., additional, Gerdts, E., additional, Bonapace, S., additional, Molon, G., additional, Targher, G., additional, Rossi, A., additional, Lanzoni, L., additional, Canali, G., additional, Campopiano, E., additional, Zenari, L., additional, Bertolini, L., additional, Barbieri, E., additional, Hristova, K., additional, Vladiomirova-Kitova, L., additional, Katova, T., additional, Nikolov, F., additional, Nikolov, P., additional, Georgieva, S., additional, Simova, I., additional, Kostova, V., additional, Kuznetsov, V. A., additional, Krinochkin, D. V., additional, Chandraratna, P. A., additional, Pak, Y. A., additional, Zakharova, E. H., additional, Plusnin, A. V., additional, Semukhin, M. V., additional, Gorbatenko, E. A., additional, Yaroslavskaya, E. I., additional, Bedetti, G., additional, Gargani, L., additional, Scalese, M., additional, Pizzi, C., additional, Sicari, R., additional, Picano, E., additional, Reali, M., additional, Canali, E., additional, Cimino, S., additional, Francone, M., additional, Mancone, M., additional, Scardala, R., additional, Boccalini, F., additional, Hiramoto, Y., additional, Frustaci, A., additional, Agati, L., additional, Savino, K., additional, Lilli, A., additional, Bordoni, E., additional, Riccini, C., additional, Ambrosio, G., additional, Silva, D., additional, Cortez-Dias, N., additional, Carrilho-Ferreira, P., additional, Jorge, C., additional, Silva-Marques, J., additional, Magalhaes, A., additional, Santos, L., additional, Ribeiro, S., additional, Pinto, F., additional, Nunes Diogo, A., additional, Kinova, E., additional, Zlatareva, N., additional, Goudev, A., additional, Bonanad, C., additional, Lopez-Lereu, M., additional, Monmeneu, J., additional, Bodi, V., additional, Sanchis, J., additional, Nunez, J., additional, Chaustre, F., additional, Llacer, A., additional, Ermacora, D., additional, Peluso, D., additional, Di Lazzari, M., additional, Meimoun, P., additional, Elmkies, F., additional, Benali, T., additional, Boulanger, J., additional, Zemir, H., additional, Clerc, J., additional, Luycx-Bore, A., additional, Velasco Del Castillo, M. S., additional, Cacicedo Fernandez De Bobadilla, A., additional, Onaindia Gandarias, J., additional, Telleria Arrieta, M., additional, Zugazabeitia Irazabal, G., additional, Quintana Raczka, O., additional, Rodriguez Sanchez, I., additional, Romero Pereiro, A., additional, Laraudogoitia Zaldumbide, E., additional, Lekuona Goya, I., additional, Bonello, B., additional, El Louali, E., additional, Fouilloux, V., additional, Kammache, I., additional, Ovaert, C., additional, Kreitmann, B., additional, Fraisse, A., additional, Migliore, R., additional, Adaniya, M., additional, Barranco, M., additional, Miramont, G., additional, Tamagusuku, H., additional, Alassar, A., additional, Sharma, R., additional, Marciniak, A., additional, Valencia, O., additional, Abdulkareem, N., additional, Jahangiri, M., additional, Jander, N., additional, Kienzle, R., additional, Gohlke-Baerwolf, C., additional, Gohlke, H., additional, Neumann, F.-J., additional, Minners, J., additional, Valbuena, S., additional, De Torres, F., additional, Lopez, T., additional, Gomez, J. J., additional, Guzman, G., additional, Dominguez, F., additional, Refoyo, E., additional, Moreno, M., additional, Lopez-Sendon, J. L., additional, Ancona, R., additional, Comenale Pinto, S., additional, Caso, P., additional, Di Salvo, G., additional, Severino, S., additional, Cavallaro, M., additional, Calabro, R., additional, Enache, R., additional, Piazza, R., additional, Roman-Pognuz, A., additional, Popescu, B., additional, Calin, A., additional, Beladan, C., additional, Purcarea, F., additional, Nicolosi, G., additional, Ginghina, C., additional, Savu, O., additional, Rosca, M., additional, Jurcut, R., additional, Serban, M., additional, Dorobantu, L., additional, Donal, E., additional, Mascle, S., additional, Thebault, C., additional, Veillard, D., additional, Hamonic, H., additional, Leguerrier, A., additional, Corbineau, H., additional, Popa, B. A., additional, Diena, M., additional, Bogdan, A., additional, Benea, D., additional, Lanzillo, G., additional, Casati, V., additional, Novelli, E., additional, Popa, A., additional, Cerin, G., additional, Gual Capllonch, F., additional, Teis, A., additional, Lopez Ayerbe, J., additional, Ferrer, E., additional, Vallejo, N., additional, Gomez Denia, E., additional, Bayes Genis, A., additional, Spethmann, S., additional, Schattke, S., additional, Baldenhofer, G., additional, Stangl, V., additional, Laule, M., additional, Baumann, G., additional, Stangl, K., additional, Knebel, F., additional, Labata, C., additional, Garcia Alonso, C., additional, Gual, F., additional, Nunez Aragon, R., additional, Sousa, C., additional, Vasile, A. I., additional, Dorobantu, M., additional, Iorgulescu, C., additional, Bogdan, S., additional, Constantinescu, D., additional, Caldararu, C., additional, Tautu, O., additional, Vatasescu, R., additional, Badran, H., additional, Elnoamany, M. F., additional, Ayad, M., additional, Elshereef, A., additional, Farhan, A., additional, Nassar, Y., additional, Yacoub, M., additional, Costabel, J., additional, Avegliano, G., additional, Elissamburu, P., additional, Thierer, J., additional, Castro, F., additional, Huguet, M., additional, Frangi, A., additional, Ronderos, R., additional, Prinz, C., additional, Van Buuren, F., additional, Faber, L., additional, Bitter, T., additional, Bogunovic, N., additional, Burchert, W., additional, Horstkotte, D., additional, Kasprzak, J. D., additional, Smialowski, A., additional, Rudzinski, T., additional, Lipiec, P., additional, Krzeminska-Pakula, M., additional, Wierzbowska-Drabik, K., additional, Trzos, E., additional, Kurpesa, M., additional, Motoki, H., additional, Hana, M., additional, Marwick, T., additional, Allan, K., additional, Vazquez-Alvarez, M., additional, Medrano Lopez, C., additional, Granja Da Silva, S., additional, Marcos, C., additional, Rodriguez-Ogando, A., additional, Alvarez, M., additional, Camino, M., additional, Centeno, M., additional, Maroto, E., additional, Feltes Guzman, G., additional, Serra Tomas, V., additional, Acevedo, O., additional, Calli, A., additional, Barba, M., additional, Pintos, G., additional, Valverde, V., additional, Zamorano Gomez, J., additional, Marchel, M., additional, Kochanowski, J., additional, Piatkowski, R., additional, Madej, A., additional, Filipiak, K., additional, Hausmanowa-Petrusewicz, I., additional, Opolski, G., additional, Malev, E., additional, Zemtsovsky, E., additional, Reeva, S., additional, Timofeev, E., additional, Pshepiy, A., additional, Mihaila, S., additional, Rimbas, R., additional, Mincu, R., additional, Dulgheru, R., additional, Mihaila, R., additional, Badiu, C., additional, Cinteza, M., additional, Vinereanu, D., additional, Lira, E., additional, Lebihan, D., additional, Monaco, C., additional, Ruiz Ortiz, M., additional, Mesa, D., additional, Delgado, M., additional, Romo, E., additional, Pena, M., additional, Puentes, M., additional, Santisteban, M., additional, Lopez Granados, A., additional, Arizon Del Prado, J., additional, Suarez De Lezo, J., additional, Tsai, W.-C., additional, Shih, J.-Y., additional, Huang, T.-S., additional, Liu, Y.-W., additional, Huang, Y.-Y., additional, Tsai, L.-M., additional, Cho, E., additional, Choi, K., additional, Kwon, B., additional, Kim, D., additional, Jang, S., additional, Park, C., additional, Jung, H., additional, Jeon, H., additional, Youn, H., additional, Kim, J., additional, Rieck, A. E., additional, Cramariuc, D., additional, Lonnebakken, M., additional, Lund, B., additional, Moceri, P., additional, Doyen, D., additional, Cerboni, P., additional, Ferrari, E., additional, Li, W., additional, Goncalves, S., additional, Vinhais De Sousa, G., additional, Almeida, A. G., additional, Hernandez Garcia, C., additional, De La Rosa Hernandez, A., additional, Arroyo Ucar, E., additional, Jorge Perez, P., additional, Barragan Acea, A., additional, Lacalzada Almeida, J., additional, Jimenez Rivera, J., additional, Duque Garcia, A., additional, Laynez Cerdena, I., additional, Arhipov, O., additional, Sumin, A. N., additional, Campens, L., additional, Renard, M., additional, Trachet, B., additional, Segers, P., additional, De Paepe, A., additional, De Backer, J., additional, Purvis, J. A., additional, Sharma, D., additional, Hughes, S. M., additional, Marek, D., additional, Vindis, D., additional, Kocianova, E., additional, Taborsky, M., additional, Yoon, H., additional, Kim, K., additional, Ahn, Y., additional, Chung, M., additional, Cho, J., additional, Kang, J., additional, Rha, W., additional, Ozcan, O., additional, Sezgin Ozcan, D., additional, Candemir, B., additional, Aras, M., additional, Dincer, I., additional, Atak, R., additional, Gianturco, L., additional, Turiel, M., additional, Atzeni, F., additional, Tomasoni, L., additional, Bruschi, E., additional, Epis, O., additional, Sarzi-Puttini, P., additional, Aggeli, C., additional, Poulidakis, E., additional, Felekos, I., additional, Sideris, S., additional, Dilaveris, P., additional, Gatzoulis, K., additional, Stefanadis, C., additional, Roszczyk, N., additional, Sobczak, M., additional, Peruga, J., additional, Krecki, R., additional, Kasprzak, J., additional, Ishii, K., additional, Suyama, T., additional, Kataoka, K., additional, Furukawa, A., additional, Nagai, T., additional, Maenaka, M., additional, Seino, Y., additional, Musca, F., additional, De Chiara, B., additional, Moreo, A., additional, Cataldo, S., additional, Parolini, M., additional, Parodi, O., additional, Bombardini, T., additional, Faita, F., additional, Park, S.-J., additional, Kil, J.-H., additional, Kim, S.-J., additional, Jang, S.-Y., additional, Chang, S.-A., additional, Choi, J.-O., additional, Lee, S.-C., additional, Park, S., additional, Park, P., additional, Oh, J., additional, Cikes, M., additional, Velagic, V., additional, Biocina, B., additional, Gasparovic, H., additional, Djuric, Z., additional, Bijnens, B., additional, Milicic, D., additional, Huqi, A., additional, Klas, B., additional, He, A., additional, Paterson, I., additional, Irween, M., additional, Ezekovitz, J., additional, Choy, J., additional, Chen, Y., additional, Cheng, L., additional, Yao, R., additional, Yao, H., additional, Chen, H., additional, Pan, C., additional, Shu, X., additional, Sobkowicz, B., additional, Kaminska, M., additional, Musial, W., additional, Buechel, R., additional, Sommer, G., additional, Leibundgut, G., additional, Rohner, A., additional, Bremerich, J., additional, Kaufmann, B., additional, Kessel-Schaefer, A., additional, Handke, M., additional, Kiotsekoglou, A., additional, Saha, S., additional, Toole, R., additional, Sharma, S., additional, Gopal, A., additional, Adhya, S., additional, Tsang, W., additional, Kenny, C., additional, Kapetanakis, S., additional, Lang, R., additional, Monaghan, M., additional, Smith, B., additional, Coulter, T., additional, Rendon, A., additional, Cheung, W.-S., additional, Gorissen, W., additional, Ejlersen, J. A., additional, May, O., additional, Van Slochteren, F. J., additional, Van Der Spoel, T., additional, Hanssen, H., additional, Doevendans, P., additional, Chamuleau, S., additional, De Korte, C., additional, Tarr, A., additional, Stoebe, S., additional, Trache, T., additional, Kluge, J.-G., additional, Varga, A., additional, Hagendorff, A., additional, Nagy, A., additional, Kovacs, A., additional, Apor, A., additional, Sax, B., additional, Becker, D., additional, Merkely, B., additional, Lindquist, R., additional, Miller, A., additional, Reece, C., additional, Eidem, B. W., additional, Choi, W.-G., additional, Kim, S., additional, Oh, S., additional, Kim, Y., additional, Iacobelli, R., additional, Chinali, M., additional, D' Asaro, M., additional, Toscano, A., additional, Del Pasqua, A., additional, Esposito, C., additional, Seghetti, G., additional, Parisi, F., additional, Pongiglione, G., additional, Rinelli, G., additional, Omaygenc, O., additional, Bakal, R., additional, Dogan, C., additional, Teber, K., additional, Akpinar, S., additional, Sahin, G., additional, Ozdemir, N., additional, Penhall, A., additional, Joseph, M., additional, Chong, F., additional, De Pasquale, C., additional, Selvanayagam, J., additional, Leong, D., additional, Nyktari, E. G., additional, Patrianakos, A. P., additional, Goudis, C., additional, Solidakis, G., additional, Parthenakis, F., additional, Vardas, P., additional, Nestaas, E., additional, Fugelseth, D., additional, Vitarelli, A., additional, Capotosto, L., additional, Bernardi, M., additional, Conde, Y., additional, Caranci, F., additional, Placanica, G., additional, Dettori, O., additional, Vitarelli, M., additional, De Chiara, S., additional, De Cicco, V., additional, Ferro', M., additional, Calabro', R., additional, Apostolakis, S., additional, Chalikias, G., additional, Tziakas, D., additional, Stakos, D., additional, Thomaidi, A., additional, Konstantinides, S., additional, Iorio, G., additional, Rucos, R., additional, Continanza, G., additional, D Ascanio, M., additional, Alessandroni, L., additional, Saponara, M., additional, Berry, M., additional, Nahum, J., additional, Zaghden, O., additional, Monin, J., additional, Couetil, J., additional, Lairez, O., additional, Macron, L., additional, Dubois Rande, J., additional, Gueret, P., additional, Lim, P., additional, Cameli, M., additional, Giacomin, E., additional, Lisi, M., additional, Benincasa, S., additional, Righini, F., additional, Menci, D., additional, Focardi, M., additional, Mondillo, S., additional, Philip, E., additional, Gorincour, G., additional, Bellsham-Revell, H., additional, Bell, A. J., additional, Miller, O. I., additional, Beerbaum, P., additional, Razavi, R., additional, Greil, G., additional, Simpson, J. M., additional, Ann, S., additional, Kim, T., additional, Lee, J., additional, Chin, J., additional, Cabeza Lainez, P., additional, Escolar Camas, V., additional, Gheorghe, L., additional, Fernandez Garcia, P., additional, Vazquez Garcia, R., additional, Caiulo, V., additional, Caiulo, S., additional, Fisicaro, A., additional, Moramarco, F., additional, Latini, G., additional, Seale, A., additional, Carvalho, J., additional, Gardiner, H., additional, Roughton, M., additional, Simpson, J., additional, Tometzki, A., additional, Uzun, O., additional, Webber, S., additional, Daubeney, P., additional, Dawood, A., additional, Dwivedi, G., additional, Mahadevan, G., additional, Jiminez, D., additional, Steeds, R., additional, Frenneaux, M., additional, Attenhofer Jost, C. H., additional, Knechtle, B., additional, Bernheim, A., additional, Pfyffer, M., additional, Linka, A., additional, Faeh-Gunz, A., additional, Seifert, B., additional, De Pasquale, G., additional, Zuber, M., additional, Tomaszewski, A., additional, Kutarski, A., additional, and Tomaszewski, M., additional

Published
2011
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21. Poster session V * Saturday 11 December 2010, 08:30-12:30

Author

Pham, Q. H., primary, Von Lueder, T. G., additional, Namtvedt, S. K., additional, Rosjo, H., additional, Omland, T., additional, Steine, K., additional, Timoteo, A. T., additional, Mota Carmo, M., additional, Simoes, M., additional, Branco, L. M., additional, Ferreira, R. C., additional, Kato, R., additional, Ito, J., additional, Tahara, T., additional, Yokoyama, Y., additional, Ashikaga, T., additional, Satoh, Y., additional, Na, J. O., additional, Hong, H. E., additional, Kim, M. N., additional, Shin, S. Y., additional, Choi, C. U., additional, Kim, E. J., additional, Rha, S. W., additional, Park, C. G., additional, Seo, H. S., additional, Oh, D. J., additional, Ticulescu, R., additional, Brigido, S., additional, Vriz, O., additional, Sparacino, L., additional, Popescu, B. A., additional, Ginghina, C., additional, Carerj, S., additional, Nicolosi, G. L., additional, Antonini-Canterin, F., additional, Onaindia Gandarias, J. J., additional, Romero, A., additional, Laraudogoitia, E., additional, Velasco, S., additional, Quintana, O., additional, Cacicedo, A., additional, Rodriguez, I., additional, Alarcon, J. A., additional, Gonzalez, J., additional, Lekuona, I., additional, Subinas, A., additional, Abdula, G., additional, Lund, L. H., additional, Winter, R., additional, Brodin, L., additional, Sahlen, A., additional, Masaki, M., additional, Cha, Y. M., additional, Yuasa, T., additional, Dong, K., additional, Dong, Y. X., additional, Mankad, S. V., additional, Oh, J. K., additional, Vallet, F., additional, Lequeux, B., additional, Diakov, C., additional, Sosner, P., additional, Christiaens, L., additional, Coisne, D., additional, Kihara, C., additional, Murata, K., additional, Wada, Y., additional, Uchida, K., additional, Ueyama, T., additional, Okuda, S., additional, Susa, T., additional, Matsuzaki, M., additional, Cho, E. J., additional, Choi, K. Y., additional, Kwon, B. J., additional, Kim, D. B., additional, Jang, S. W., additional, Cho, J. S., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, J. H., additional, Cikes, M., additional, Bijnens, B., additional, Velagic, V., additional, Kopjar, T., additional, Milicic, D., additional, Biocina, B., additional, Gasparovic, H., additional, Almuntaser, I., additional, Brown, A., additional, Foley, B., additional, Mulvihill, N., additional, Crean, P., additional, King, G., additional, Murphy, R., additional, Takata, Y., additional, Taniguchi, M., additional, Nobusada, S., additional, Sugawara, M., additional, Toh, N., additional, Kusano, K., additional, Itoh, H., additional, Wellnhofer, E., additional, Kriatselis, C., additional, Nedios, S., additional, Gerds-Li, J. H., additional, Fleck, E., additional, Poulsen, M. K., additional, Henriksen, J. E., additional, Dahl, J., additional, Johansen, A., additional, Haghfelt, T., additional, Hoilund-Carlsen, P. 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C., additional, Attanasio, M., additional, Abbate, R., additional, Gensini, G. F., additional, Pepe, G., additional, Duncan, R. F., additional, Piantadosi, C., additional, Nelson, A. J., additional, Wittert, G., additional, Dundon, B., additional, Worthley, M. I., additional, Worthley, S. G., additional, Jung, P., additional, Berlinger, K., additional, Rieber, J., additional, Sohn, H. Z., additional, Schneider, P., additional, Leibig, M., additional, Koenig, A., additional, Klauss, V., additional, Tomkiewicz-Pajak, L., additional, Kolcz, J., additional, Olszowska, M., additional, Pieculewicz, M., additional, Podolec, P., additional, Przewlocki, T., additional, Suchon, E., additional, Sobien, B., additional, Wilkolek, P., additional, Ziembicka, A., additional, Hlawaty, M., additional, Van De Bruaene, A., additional, Hermans, H., additional, Buys, R., additional, Vanhees, L., additional, Delcroix, M., additional, Voigt, J.-U., additional, Budts, W., additional, De Cillis, E., additional, Acquaviva, T., additional, Basile, D., additional, Bortone, A. S., additional, Kalimanovska-Ostric, D., additional, Nastasovic, T., additional, Vujisic-Tesic, B., additional, Jovanovic, I., additional, Milakovic, B., additional, Dostanic, M., additional, Stosic, M., additional, Frogoudaki, A., additional, Andreou, K., additional, Parisis, J., additional, Triantafyllidi, E., additional, Gaitani, S., additional, Paraskevaidis, J., additional, Anastasiou-Nana, M., additional, De Pasquale, G., additional, Kuehn, A., additional, Petzuch, K., additional, Mueller, J., additional, Meierhofer, C., additional, Fratz, S., additional, Hager, A., additional, Hess, J., additional, Vogt, M., additional, Attenhofer Jost, C. H., additional, Dearani, J. A., additional, Scott, C. G., additional, Burkhart, H. M., additional, Connolly, H. M., additional, Vitarelli, A., additional, Battaglia, D., additional, Caranci, F., additional, Padella, V., additional, Continanza, G., additional, Dettori, O., additional, Capotosto, L., additional, Vitarelli, M., additional, De Cicco, V., additional, Cortez Morichetti, M., additional, Mohanan Nair, K. K., additional, Sasidaharan, B., additional, Thajudeen, A., additional, Tharakan, J. M., additional, Mertens, L., additional, Ahmad, N., additional, Kantor, P. K., additional, Grosse-Wortmann, L., additional, Friedberg, M. K., additional, Bernard, Y. F., additional, Morel, M. A., additional, Descotes-Genon, V., additional, Jehl, J., additional, Meneveau, N., additional, Schiele, F., additional, Kaldararova, M., additional, Simkova, I., additional, Tittel, P., additional, Masura, J., additional, Trojnarska, O., additional, Szczepaniak, L., additional, Mizia -Stec, K., additional, Cieplucha, A., additional, Bartczak, A., additional, Grajek, S., additional, Tykarski, A., additional, Gasior, Z., additional, Babovicvuksanovic, D., additional, Bonnichsen, C. R., additional, Morgan, G. J., additional, Slorach, C., additional, Hui, W., additional, Sarkola, T., additional, Lee, K. J., additional, Chaturvedi, R., additional, Benson, L., additional, Bradley, T., additional, Iancu, M. E., additional, Ghiorghiu, I., additional, Serban, M., additional, Craciunescu, I., additional, Hodo, A., additional, Morgan, J., additional, Roche, L., additional, Lee, K., additional, Milanesi, O., additional, Favero, V., additional, Padalino, M., additional, Biffanti, R., additional, Cerutti, A., additional, Maschietto, N., additional, Reffo, E., additional, Vida, V., additional, Stellin, G., additional, Irtyuga, O., additional, Gamazin, D., additional, Voronkina, I., additional, Tsoyi, N., additional, Gudkova, E., additional, Moiseeva, O., additional, Aggeli, C., additional, Kazazaki, C., additional, Felekos, I., additional, Lagoudakou, S., additional, Roussakis, G., additional, Skoumas, J., additional, Pitsavos, C., additional, Stefanadis, C., additional, Cueff, C., additional, Keenan, N., additional, Steg, P. G., additional, Cimadevilla, C., additional, Ducrocq, G., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Petrella, L., additional, Mazzola, A. M., additional, Villani, C. V., additional, Giancola, R. G., additional, Ciocca, M. C., additional, Di Eusanio, D. E. M., additional, Nolan, S., additional, Ionescu, A., additional, Skaug, T. R., additional, Amundsen, B. H., additional, Hergum, T., additional, Torp, H., additional, Haugen, B. O., additional, Lopez Aguilera, J., additional, Mesa Rubio, D., additional, Ruiz Ortiz, M., additional, Delgado Ortega, M., additional, Villanueva Fernandez, E., additional, Cejudo Diaz Del Campo, L., additional, Toledano Delgado, F., additional, Leon Del Pino, M., additional, Romo Pena, E., additional, Suarez De Lezo Cruz-Conde, J., additional, De Marco, E., additional, Colucci, A., additional, Comerci, G., additional, Gabrielli, F. A., additional, Natali, R., additional, Garramone, B., additional, Savino, M., additional, Lotrionte, M., additional, Sonaglioni, A., additional, Loperfido, F., additional, Zdravkovic, M., additional, Perunicic, J., additional, Krotin, M., additional, Ristic, M., additional, Vukomanovic, V., additional, Zaja, M., additional, Radovanovic, S., additional, Saric, J., additional, Zdravkovic, D., additional, Cotrim, C., additional, Almeida, A. R., additional, Miranda, R., additional, Almeida, A. G., additional, Picano, E., additional, Carrageta, M., additional, D'andrea, A., additional, Cocchia, R., additional, Riegler, L., additional, Golia, E., additional, Scarafile, R., additional, Caso, P., additional, Russo, M. G., additional, Bossone, E., additional, Calabro', R., additional, Noman, H., additional, Adel, A., additional, Elfaramawy, A. M. R., additional, Abdelraouf, M., additional, Elnaggar, W. A. E. L., additional, Baligh, E., additional, Sargento, L., additional, Silva, D., additional, Goncalves, S., additional, Ribeiro, S., additional, Vinhas Sousa, G., additional, Almeida, A., additional, Lopes, M., additional, Rodriguez-Manero, M., additional, Aguado Gil, L., additional, Azcarate, P., additional, Lloret Luna, P., additional, Macias Gallego, A., additional, Castano, S. A. R. A., additional, Garcia, M., additional, Pujol Salvador, C., additional, Barba, J., additional, Redondo, P., additional, Tomasoni, L., additional, Sitia, S., additional, Atzeni, F., additional, Gianturco, L., additional, Ricci, C., additional, Sarzi-Puttini, P., additional, Turiel, M., additional, De Gennaro Colonna, V., additional, Uejima, T., additional, Jaroch, J., additional, Polombo, C., additional, Hughes, A., additional, Vinereanu, D., additional, Evanvelista, A., additional, Leftheriotis, G., additional, Fraser, A. G., additional, Lewczuk, A., additional, Sobkowicz, B., additional, Tomaszuk-Kazberuk, A., additional, Sawicki, R., additional, Hirnle, T., additional, Michalski, B. W., additional, Filipiak, D., additional, Kasprzak, J. D., additional, Lipiec, P., additional, Dalen, H., additional, Mjolstad, O. C., additional, Klykken, B. E., additional, Graven, T., additional, Martensson, M., additional, Olsson, M., additional, Brodin, L.-A., additional, Enache, R., additional, Leiballi, E., additional, Penhall, A., additional, Perry, R., additional, Altman, M., additional, Sinhal, A., additional, Bennetts, J., additional, Chew, D. P., additional, Joseph, M. X., additional, Larsen, L. H., additional, Kristensen, T., additional, Kober, L. V., additional, Kofoed, K. F., additional, Moscoso Costa, F., additional, Ribeiras, R., additional, Brito, J., additional, Boshoff, S., additional, Neves, J., additional, Teles, R., additional, Canada, M., additional, Andrade, M. J., additional, Gouveia, R., additional, Silva, A., additional, Miskovic, A., additional, Poerner, T. P., additional, Stiller, C. S., additional, Goebel, B. G., additional, Moritz, A. M., additional, Stefani, L., additional, Galanti, G. G., additional, Moraldo, M., additional, Bergamini, C., additional, Pabari, P. A., additional, Dhutia, N. M., additional, Malaweera, A. S. N., additional, Willson, K., additional, Davies, J., additional, Hughes, A. D., additional, Xu, X. Y., additional, Francis, D. P., additional, Jasaityte, R., additional, Amundsen, B., additional, Barbosa, D., additional, Loeckx, D., additional, Kiss, G., additional, Orderud, F., additional, Robesyn, V., additional, Claus, P., additional, D'hooge, J., additional, Nao, T., additional, Miura, T., additional, Shams, K., additional, Samir, S., additional, Samir, R., additional, El-Sayed, M., additional, Anwar, A. M., additional, Nosir, Y., additional, Galal, A., additional, Chamsi-Pasha, H., additional, Ciobanu, A., additional, Dulgheru, R., additional, Bennett, S., additional, De Luca, A., additional, Toncelli, L., additional, Cappelli, F., additional, Cappelli, B., additional, Vono, M. C. R., additional, Galanti, G., additional, Zorman, Y., additional, Yilmazer, M. S., additional, Akyildiz, M., additional, Gurol, T., additional, Aydin, A., additional, Dagdeviren, B., additional, and Kalangos, A., additional

Published
2010
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31. Transesophageal Echocardiography in Comparison with Magnetic Resonance Imaging in the Diagnosis of Pulmonary Vein Stenosis after Radiofrequency Ablation Therapy

Author

Jander, N., Minners, J., Arentz, T., Gornandt, L., Furmaier, R., Kalusche, D., and Neumann, F.J.

Abstract

Objective: Doppler-derived flow velocity measured by transesophageal echocardiography (TEE) may overestimate pulmonary vein stenosis. We hypothesized that combining peak velocity with a stenotic flow pattern improves diagnosis compared with magnetic resonance imaging (MRI). Methods: TEE and MRI were performed in 44 patients 19 +/- 11 months after radiofrequency catheter ablation. Pulmonary vein stenosis was defined by a peak velocity of 110 cm/s or more plus a stenotic flow pattern (turbulence and reduced flow variation) on TEE and a lumen reduction of more than 50% on MRI. Results: In all, 175 pulmonary veins were studied. MRI showed 7 cases of pulmonary vein stenosis that were correctly identified by TEE. In addition, TEE criteria for pulmonary vein stenosis were met in 4 pulmonary veins that did not show obstruction on MRI. In all, 5 pulmonary veins with normal appearance on MRI had peak velocity of 110 cm/s or more with normal flow pattern. Conclusions: TEE Doppler measurements can be reliably used to detect or exclude significant pulmonary vein stenosis if the diagnosis is restricted to a combination of elevated peak velocity (>= 110 cm/s) with turbulence and little flow variation.

Published
2005
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36. Quantification of Aortic Valve Calcification in Contrast-Enhanced Computed Tomography.

Author

Laohachewin D, Ruile P, Breitbart P, Minners J, Jander N, Soschynski M, Schlett CL, Neumann FJ, Westermann D, and Hein M

Abstract

Background : The goal of our study is to evaluate a method to quantify aortic valve calcification (AVC) in contrast-enhanced computed tomography for patients with suspected severe aortic stenosis pre-interventionally. Methods : A total of sixty-five patients with aortic stenosis underwent both a native and a contrast-enhanced computed tomography (CECT) scan of the aortic valve (45 in the training cohort and 20 in the validation cohort) using a standardized protocol. Aortic valve calcification was semi-automatically quantified via the Agatston score method for the native scans and was used as a reference. For contrast-enhanced computed tomography, a calcium threshold of the Hounsfield units of the aorta plus four times the standard deviation was used. Results : For the quantification of aortic valve calcification in contrast-enhanced computed tomography, a conversion formula (691 + 1.83 x AVCCECT) was derived via a linear regression model in the training cohort. The validation in the second cohort showed high agreement for this conversion formula with no significant proportional bias (Bland-Altman, p = 0.055) and with an intraclass correlation coefficient in the validation cohort of 0.915 (confidence interval 95% 0.786-0.966) p < 0.001. Conclusions : Calcium scoring in patients with aortic valve stenosis can be performed using contrast-enhanced computed tomography with high validity. Using a conversion factor led to an excellent agreement, thereby obviating an additional native computed tomography scan. This might contribute to a decrease in radiation exposure.

Published
2024
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38. In-Hospital Outcomes Following Surgical Revascularization of Chronic Total Coronary Occlusions.

Author

Fagu A, Berger T, Pingpoh C, Kondov S, Kreibich M, Minners J, Czerny M, and Siepe M

Subjects
Humans, Aged, Retrospective Studies, Treatment Outcome, Hospitals, Risk Factors, Coronary Occlusion surgery, Percutaneous Coronary Intervention methods, Coronary Artery Disease surgery, Peripheral Arterial Disease etiology
Abstract

Background and Objectives : Patients with chronic total occlusions of the coronary arteries are either treated with PCI or referred for surgical revascularization. We analyzed the patients with chronic occluded coronary arteries that were surgically treated and aimed to describe the anatomical characteristics, revascularization rates, and in-hospital outcomes achieved with coronary artery bypass grafting. Methods : Angiographic data of 2005 patients with coronary artery disease treated in our institution between January 2005 and December 2014 were retrospectively analyzed. A total of 1111 patients with at least one coronary total occlusion were identified. We reviewed the preoperative coronary angiograms and surgical protocols to determine the presence, localization, and revascularization of coronary occlusions. We also evaluated the perioperative data and in-hospital outcomes. Results : The median age of the study population was 68 years (25th-75th percentiles, 61.0-74.0). Three-vessel disease was present in 94.8% of patients and the rest (5.8%) had a two-vessel disease. The localizations of the occlusions were as follows: 68.4% in the RCA system, 26.4% in the LAD, and 28.5% in the LCX system. Multiple occlusions were present in 22.6% of the patients. Complete coronary total occlusion revascularization was achieved in 86.1% of the patients. The overall in-hospital mortality was 2.3%. The median in-hospital stay was 14.0 days. After logistic regression analysis, age (odds ratio 3.44 [95% confidence interval, 1.81-6.53], p < 0.001, for a 10-year increase) and the presence of peripheral artery disease (odds ratio 3.32 [1.39-7.93], p = 0.007) were the only statistically significant independent predictors of in-hospital mortality. Conclusions : A high revascularization rate and favorable in-hospital outcomes are achieved with coronary artery bypass surgery in patients with multi-vessel diseases and coronary total occlusions. Older age and the presence of peripheral artery disease are independent predictors of in-hospital mortality. A long-term follow-up and the type of graft (arterial vs. venous) used would bring more useful data for this type of revascularization.

Published
2023
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39. Feasibility and safety of a three-dimensional anatomic map-guided transseptal puncture for left-sided catheter ablation procedures.

Author

Bohnen M, Minners J, Eichenlaub M, Weber R, Allgeier HJ, Jadidi A, Neumann FJ, Westermann D, Arentz T, and Lehrmann H

Subjects
Humans, Feasibility Studies, Cardiac Catheterization methods, Heart Atria, Punctures, Treatment Outcome, Catheter Ablation adverse effects, Catheter Ablation methods, Atrial Fibrillation diagnostic imaging, Atrial Fibrillation surgery
Abstract

Aims: Transseptal puncture (TP) for left-sided catheter ablation procedures is routinely performed under fluoroscopic or echocardiographic guidance [transoesophageal echocardiography (TEE) or intracardiac echocardiography (ICE)], although three-dimensional (3D) mapping systems are readily available in most electrophysiology laboratories. Here, we sought to assess the feasibility and safety of a right atrial (RA) 3D map-guided TP., Methods and Results: In 104 patients, 3D RA mapping was performed to identify the fossa ovalis (FO) using the protrusion technique. The radiofrequency transseptal needle was visualized and navigated to the desired potential FO-TP site. Thereafter, the interventionalist was unblinded to TEE and the potential FO-TP site was reassessed regarding its convenience and safety. After TP, the exact TP site was documented using a 17-segment-FO model. Reliable identification of the FO was feasible in 102 patients (98%). In these, 114 3D map-guided TP attempts were performed, of which 96 (84%) patients demonstrated a good position and 18 (16%) an adequate position after TEE unblinding. An out-of-FO or dangerous position did not occur. A successful 3D map-guided TP was performed in 110 attempts (97%). Four attempts (3%) with adequate positions were aborted in order to seek a more convenient TP site. The median time from RA mapping until the end of the TP process was 13 (12-17) min. No TP-related complications occurred. Ninety-eight TP sites (85.1%) were in the central portion or in the inner loop of the FO., Conclusion: A 3D map-guided TP is feasible and safe. It may assist to decrease radiation exposure and the need for TEE/ICE during left-sided catheter ablation procedures., Competing Interests: Conflict of interest: D.W. reports lecture fees paid from Abiomed, AstraZeneca, Bayer Healthcare, Boehringer Ingelheim, Edwards LiveScience, Novartis, and Medtronic. F.-J.N. reports lecture fees paid to his institution from Amgen, Bayer Healthcare, Boehringer Ingelheim, Boston Scientific, Daiichi Sankyo, Edwards Lifesciences, Ferrer, Pfizer, and Novartis; consultancy fees paid to his institution from Boehringer Ingelheim and Novartis; and grant support from Bayer Healthcare, Boston Scientific, Biotronik, Edwards Lifesciences, GlaxoSmithKline, Medtronic, Pfizer, and Abbot Vascular. All remaining authors have no conflicts to disclose., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2023
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40. Characterization of circumferential antral pulmonary vein isolation areas resulting from pulsed-field catheter ablation.

Author

Bohnen M, Weber R, Minners J, Jadidi A, Eichenlaub M, Neumann FJ, Arentz T, and Lehrmann H

Subjects
Humans, Middle Aged, Aged, Heart Atria, Catheters, Treatment Outcome, Pulmonary Veins diagnostic imaging, Pulmonary Veins surgery, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Catheter Ablation methods
Abstract

Aims: The cornerstone of pulmonary vein (PV) isolation (PVI) is a wide-area circumferential ablation (WACA) resulting in an antral PVI area. Pulsed-field ablation (PFA) is a new nonthermal 'single-shot' PVI technique resulting in well-characterized posterior isolation areas. However, information on circumferential PVI area is lacking. Thus, we sought to characterize the circumferential antral PVI areas after PFA-PVI., Methods and Results: Atrial fibrillation (AF) patients underwent fluoroscopy-guided PVI with a pentaspline PFA catheter. Ultra-high-density voltage maps using a 20-polar circular mapping catheter were created before and immediately after PVI to identify and quantify (i) insufficient isolation areas per antral PV segment (10-segment model) and (ii) enlarged left atrial (LA) isolation areas (beyond the antral PV segments) per LA region (8-region model). The PFA-PVI with pre- (5469 ± 1822 points) and post-mapping (6809 ± 2769 points) was performed in 40 consecutive patients [age 62 ± 6 years, 25/40 (62.5%) paroxysmal AF]. Insufficient isolation areas were located most frequently in the anterior antral PV segments of the left PVs (62.5-77.5% of patients) with the largest extent (median ≥0.4 cm2) located in the same segments (segments 2/5/8). Enlarged LA isolation areas were located most frequently and most extensively on the posterior wall and roof region (89.5-100% of patients; median 1.1-2.7 cm2 per region)., Conclusion: Fluoroscopy-guided PFA-PVI frequently results in insufficient isolation areas in the left anterior antral PV segments and enlarged LA isolation areas on the posterior wall/roof, which both may be extensive. To optimize the procedure, full integration of PFA catheter visualization into three-dimensional-mapping systems is needed., Competing Interests: Conflict of interest: M.B. reports educational grant support from Boston Scientific (Fellowship ‘Herzrhythmus’). F.J.N. reports lecture fees paid to his institution from Amgen, Bayer Healthcare, Boehringer Ingelheim, Boston Scientific, Daiichi Sankyo, Edwards Lifesciences, Ferrer, Pfizer, Novartis; consultancy fees paid to his institution from Boehringer Ingelheim, Novartis, and grant support from Bayer Healthcare, Boston Scientific, Biotronik, Edwards Lifesciences, GlaxoSmithKline, Medtronic, Pfizer, Abbot Vascular. All the remaining authors have declared no conflicts of interest., (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2023
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41. 3D mapping of phrenic nerve course for radiofrequency pulmonary vein isolation.

Author

Bohnen M, Weber R, Minners J, Eichenlaub M, Jadidi A, Müller-Edenborn B, Neumann FJ, Arentz T, and Lehrmann H

Subjects
Male, Humans, Female, Phrenic Nerve injuries, Vena Cava, Superior surgery, Heart Atria surgery, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Atrial Fibrillation complications, Pulmonary Veins surgery, Catheter Ablation adverse effects, Catheter Ablation methods, Peripheral Nerve Injuries diagnosis, Peripheral Nerve Injuries etiology, Peripheral Nerve Injuries prevention & control
Abstract

Introduction: Phrenic nerve (PN) injury is a rare but severe complication of radiofrequency (RF) pulmonary vein isolation (PVI). The objective of this study was to characterize the typical intracardiac course of the PN with a three-dimensional electroanatomic mapping system, to quantify the need for modification of the ablation trajectory to avoid delivering an ablation lesion on sites with PN capture, and to identify very circumscribed areas of common PNC on the routine ablation trajectory of a RF-PVI, allowing fast and effective PN screening for everyday usage., Methods: We enrolled 137 consecutive patients (63 ± 9 years, 64% men) undergoing PVI. A detailed high output (20 mA) pace-mapping protocol was performed in the right (RA) and left atrium (LA) and adjacent vasculature., Results: The right PN was most commonly captured in the superior vena cava at a lateral (50%) or posterolateral (23%) position before descending along the RA either straight (29%) or with a posterolateral bend (20%). In the LA, beginning deep within the right superior pulmonary vein (RSPV), the right PN is most frequently detectable anterolateral (31%), then descends to the lateral proximal RSPV (23%), and further towards the lateral antral region (15%) onto the medial LA wall (12%). To avoid delivering an ablation lesion on sites with PN capture, modification of ablation trajectory was necessary in 23% of cases, most commonly in the lateral RSPV antrum (81%). No PN injury occurred., Conclusion: PN mapping frequently reveals the close proximity of the PN to the ablation trajectory during PVI, particularly in the lateral RSPV antrum. Routine PN pacing should be considered during RF PVI procedures., (© 2022 The Authors. Journal of Cardiovascular Electrophysiology published by Wiley Periodicals LLC.)

Published
2023
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42. Pulmonary Capillary Wedge Pressure during Exercise Is Prognostic for Long-Term Survival in Patients with Symptomatic Heart Failure.

Author

Ahlgrim C, Kocher S, Minners J, Jander N, Savarese G, Neumann FJ, Arentz T, Jadidi A, and Mueller-Edenborn B

Abstract

Aims: Exercise stress testing can stratify specific populations of heart failure patients for mortality risk, but is not universally applied. The aim of the present study was to investigate the prognostic capabilities of invasive exercise testing in a real-world cohort of suspected heart failure patients in whom non-cardiac causes of dyspnea were excluded. Methods: We retrospectively analyzed the survival of 682 patients who underwent right heart catheterization at rest and during exercise between 2007 and 2017 for dyspnea and expected heart failure. Pulmonary capillary wedge pressure (PCWP) at rest and the PCWP response to exercise, expressed as the ratio of PCWP at peak exercise to workload normalized to body weight (PCWL (mmHg/W/kg)), were determined. Mortality data were retrieved from the official German death registry. Results: Over a median follow-up period of 8.5 years, PCWL is a stronger predictor of all-cause mortality than PCWP. Patients featuring a reduced left ventricular ejection fraction (LVEF; <50%), but favorable response to exercise (PCWL <34.7 mmHg/W/kg), have a similar mortality risk to patients with a normal LVEF and low PCWL (hazard ratio (HR) 1.180, 95% CI 0.48−2.91, p = 0.719). Irrespective of LVEF, an increased PCWL during exercise was associated with a significantly increased mortality (HR 1.950 with preserved LVEF, 95% CI 1.12−3.34, p = 0.018; and HR 3.212 with impaired LVEF, 95% CI 1.75−5.70, p < 0.001). Conclusions: In patients with clinical heart failure, invasive exercise testing improves the prediction of mortality. Subjects with a favorable response to exercise have a relatively low mortality irrespective of left ventricular systolic function.

Published
2022
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43. Comparison of various late gadolinium enhancement magnetic resonance imaging methods with high-definition voltage and activation mapping for detection of atrial cardiomyopathy.

Author

Eichenlaub M, Mueller-Edenborn B, Minners J, Figueras I Ventura RM, Forcada BR, Colomer AV, Hein M, Ruile P, Lehrmann H, Schoechlin S, Allgeier J, Bohnen M, Trenk D, Neumann FJ, Arentz T, and Jadidi A

Subjects
Contrast Media, Female, Gadolinium, Heart Atria diagnostic imaging, Heart Atria pathology, Heart Atria surgery, Humans, Magnetic Resonance Imaging methods, Male, Atrial Fibrillation diagnostic imaging, Atrial Fibrillation surgery, Cardiomyopathies, Catheter Ablation methods
Abstract

Aims: Atrial cardiomyopathy (ACM) is associated with increased arrhythmia recurrence rates after pulmonary vein isolation (PVI). We compare the most common left atrial (LA) late gadolinium enhancement magnetic resonance imaging (LGE-MRI)-methods [Utah-method and image intensity ratio (IIR)-methods] and endocardial voltage mapping for ACM-detection and outcome prediction after PVI for atrial fibrillation (AF)., Methods and Results: In this prospective observational study, 37 ablation-naive patients (66 ± 9 years, 84% male) with persistent AF underwent LA-LGE-MRI and high-definition voltage and activation mapping (2129 ± 484 sites) in sinus rhythm prior to PVI. The MRI-post-processing-analyses were performed by two independent expert laboratories. Arrhythmia recurrence was recorded within 12 months following PVI. The global ACM-extent was highly variable: median LA low-voltage substrate (LA-LVS) was 12.9% at <1.0 mV and 2.7% at <0.5 mV; median LA-LGE-extent using the Utah-method was 18.3% and 0.03-93.1% using the IIR-methods. The LA activation time was significantly correlated with LA-LVS (r = 0.76 at <0.5 mV and r = 0.82 at <1.0 mV, both P < 0.0001), but not with LA-LGE-extent. The highest regional matching between LA-LVS <0.5 mV and LA-LGE was found for the anterior wall in 57% of patients using the Utah-method and in 59% using IIR 1.20. The corresponding values for the posterior wall were 19% and 38%, respectively. Arrhythmia recurrence occurred in 15(41%) patients. Freedom from arrhythmia was significantly lower in those with LA-LVS ≥2 cm2 at 0.5 mV but not in those with LGE ≥20% (Utah-stages III and IV): 43% vs. 81%, P = 0.009 and 50% vs. 67%, P = 0.338, respectively., Conclusion: Comparison of the most common LA-LGE-MRI methods and endocardial voltage mapping revealed large discrepancies in global and regional ACM-extent., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2022. For permissions, please email: journals.permissions@oup.com.)

Published
2022
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44. Long-Term Follow-Up of Hypoattenuated Leaflet Thickening After Transcatheter Aortic Valve Replacement.

Author

Hein M, Schoechlin S, Schulz U, Minners J, Breitbart P, Lehane C, Neumann FJ, and Ruile P

Subjects
Aortic Valve diagnostic imaging, Aortic Valve surgery, Follow-Up Studies, Humans, Risk Factors, Treatment Outcome, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Heart Valve Prosthesis, Transcatheter Aortic Valve Replacement adverse effects
Abstract

Background: Early hypoattenuated leaflet thickening (HALT) occurs in at least 10% of all transcatheter aortic valve replacement (TAVR) patients. The long-term prognostic impact of HALT is uncertain., Objectives: The aim of this study was to assess the long-term risk of early HALT post-TAVR., Methods: We report outcome data from our prospective observational registry with post-TAVR computed tomography angiography performed between May 2012 and December 2017. The outcomes were survival, cardiovascular mortality, ischemic cerebrovascular events, and symptomatic hemodynamic valve deterioration., Results: Early HALT was diagnosed in 115 (16.0%) of 804 patients. During a median follow-up of 3.25 years, survival rates did not differ significantly between patients with and without HALT (Kaplan-Meier 3-year estimates for survival 70.1% vs 74.0%, P = 0.597). The 3-year cardiovascular mortality rate was 13.2% versus 11.3% (with vs without HALT, P = 0.733). The 3-year event rate for cerebrovascular events was 2.0% versus 4.4% (with vs without HALT, P = 0.246), and the 3-year event rate of symptomatic hemodynamic valve deterioration was 9.4% versus 1.5% (with vs without HALT, P < 0.001). Multivariable analysis revealed the following predictors of symptomatic hemodynamic valve deterioration: HALT (HR: 6.10; 95% CI: 2.59-14.29; P < 0.001), the mixed valve-type group (HR: 6.51; 95% CI: 2.38-17.81; P < 0.001), and prosthesis diameter (HR valve size per 3 mm [HR: 0.37; 95% CI: 0.17-0.79]; P = 0.011)., Conclusions: During a median follow-up of more than 3 years, HALT was not associated with mortality or cerebrovascular events. However, we observed an association of HALT with symptomatic hemodynamic valve deterioration., Competing Interests: Funding Support and Author Disclosures Prof Neumann reports that his institution has received research grants, consultancy fees, and speaker honoraria to form Daiichi-Sankyo, AstraZeneca, Sanofi, Bayer, The Medicines Company, Bristol Myers Squibb, Novartis, Roche, Boston Scientific, Biotronik, Medtronic, Edwards, and Ferrer. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)

Published
2022
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45. Impact of the Aortic Geometry on TAVI Prosthesis Positioning Using Self-Expanding Valves.

Author

Breitbart P, Czerny M, Minners J, Schröfel H, Neumann FJ, and Ruile P

Abstract

Background: The impact of transcatheter heart valve (THV) position on the occurrence of paravalvular leakage and permanent pacemaker implantation caused by new-onset conduction disturbances is well described. The purpose of this study was to investigate the influence of the geometry of the thoracic aorta on the implantation depth after TAVI (transcatheter heart valve implantation) using self-expanding valve (SEV) types., Methods: We evaluated three-dimensional geometry of the thoracic aorta based on computed tomography angiography (CTA) in 104 subsequently patients receiving TAVI with SEV devices (Evolut R). Prosthesis position was determined using the fusion imaging method of pre- and post-procedural CTA. An implantation depth of ≥4 mm was defined as the cut-off value for low prosthesis position., Results: The mean implantation depth of the THV in the whole cohort was 4.3 ± 3.0 mm below annulus plane. THV position was low in 66 (63.5%) patients and high in 38 (36.5%) patients. After multivariate adjustment none of the aortic geometry characteristics showed an independent influence on the prosthesis position-neither the Sinus of Valsalva area ( p = 0.335) nor the proximal aortic arch diameter ( p = 0.754) or the distance from annulus to descending aorta ( p = 0.309)., Conclusion: The geometry of the thoracic aorta showed no influence on the positioning of self-expanding TAVI valve types.

Published
2022
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46. Performance of Computed Tomography Angiography (CTA) for the Diagnosis of Hypo-Attenuated Leaflet Thickening (HALT).

Author

Hein M, Breitbart P, Minners J, Blanke P, Schoechlin S, Schlett C, Krauss T, Soschynski M, Neumann FJ, and Ruile P

Abstract

(1) Background: Early hypo-attenuated leaflet thickening (HALT) is diagnosed by computed tomography angiography (CTA) in approximately 15% of patients undergoing transcatheter aortic valve replacement (TAVR). We sought to investigate the diagnostic performance of CTA for the diagnosis of HALT, focusing on timing data assessment within the cardiac cycle. (2) Methods: The study enrolled 50 patients with and 50 without HALT with available post-TAVR-CTA. The primary objective was to compare the diagnostic performance of CTA readings at specific intervals and time points during the cardiac cycle (entire systole, entire diastole, end-systole, and mid-diastole) versus gold standard (consensus reading by two observers based on multiphase full cardiac cycle data sets). (3) Results: 100 CTAs were independently analysed by two observers blinded to clinical characteristics of the study population and the results from the gold standard reading. Sensitivity and specificity for the diagnosis of HALT were 84%/94% in systole, 87%/92% in diastole, 78%/95% at end-systole, and 80%/94% at mid-diastole. End-systole had the highest positive predictive value (0.88) and positive likelihood ratio (36). Cohen's kappa for interobserver reliability was 0.715 in systole, 0.578 in diastole, 0.650 at end-systole, and 0.517 at mid-diastole. (4) Conclusion: Limiting CTA reading to distinct intervals or time points during the cardiac cycle has good specificity but lowers sensitivity. For a reliable diagnosis of HALT, data sets from a multiphase CTA covering the entire cardiac cycle should be analysed. A double reader approach would be desirable in further studies investigating HALT.

Published
2022
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47. Prognostic impact of invasive exercise haemodynamics in patients with severe mitral regurgitation.

Author

Hein M, Neu J, Doerken S, Schoechlin S, Dorfs S, Zeh W, Pingpoh C, Neumann FJ, Minners J, and Jander N

Subjects
Female, Hemodynamics, Humans, Male, Middle Aged, Prognosis, Pulmonary Wedge Pressure, Retrospective Studies, Mitral Valve Insufficiency
Abstract

Objectives: Abnormal invasive exercise haemodynamics in asymptomatic patients with severe mitral regurgitation were associated with higher regurgitation burden. We analysed the association between parameters of invasive exercise testing with mortality and valve surgery compared to guideline defined non-invasive criteria., Methods: This single centre, retrospective cohort study assesses the association of invasive exercise haemodynamics and mortality with and without surgery in patients with severe mitral regurgitation and normal ejection fraction (≥55%) as primary outcome. The secondary outcome was the need for mitral valve surgery in 113 asymptomatic patients primarily managed conservatively., Results: We identified 314 patients [age 59 years (standard deviation 13), 27% female] with available exercise haemodynamics with a median follow-up of 8.2 (interquartile range 5.2-11.2) years. Five-year survival rate was 93.0%. Pulmonary capillary wedge pressure at maximum exercise >30 mmHg was the only parameter independently associated with mortality after adjustment for age and guideline criteria [hazard ratio (HR) 2.7 (1.3-5.6), P = 0.007]. In the 113 patients primarily managed conservatively, maximum pulmonary capillary wedge pressure was independently associated with mitral valve surgery during follow-up in multivariable analysis (HR 2.10 (1.32-3.34), P = 0.002; after adjustment for workload and weight: HR 1.31 (1.14-1.52), P < 0.001], whereas systolic pulmonary artery pressure and current guideline criteria were not. Adding maximum pulmonary capillary wedge pressure >25 mmHg improved the predictive power of current guideline criteria for surgery (area under the curve 0.61-0.68, P = 0.02)., Conclusions: Invasive exercise haemodynamics predict mortality and improve prognostic information about surgery during follow-up derived from current guideline criteria in asymptomatic patients with severe mitral regurgitation., (© The Author(s) 2021. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)

Published
2022
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48. Electrocardiographic diagnosis of atrial cardiomyopathy to predict atrial contractile dysfunction, thrombogenesis and adverse cardiovascular outcomes.

Author

Müller-Edenborn B, Minners J, Keyl C, Eichenlaub M, Jander N, Abdelrazek S, Ahlgrim C, Allgeier J, Lehrmann H, Neumann FJ, Arentz T, and Jadidi A

Subjects
Aged, Aged, 80 and over, Atrial Appendage, Atrial Function, Left, Case-Control Studies, Female, Humans, Male, Middle Aged, Severity of Illness Index, Thrombosis complications, Atrial Fibrillation complications, Cardiomyopathies diagnosis, Electrocardiography methods, Thrombosis diagnosis
Abstract

Thromboembolism and stroke are dreaded complications in atrial fibrillation (AF). Established risk stratification models identify susceptible patients, but their discriminative properties are poor. Atrial cardiomyopathy (ACM) is associated to thromboembolism and stroke in smaller studies, but the modalities used for ACM-diagnosis (MRI and endocardial mapping) are unsuitable for widespread population screening. We aimed to investigate an ECG-based diagnosis of ACM using amplified p-wave analysis (APWA) for stratification of thromboembolic risk and cardiovascular outcome. In this case-control study, ACM-staging was performed using APWA on digital 12-lead sinus rhythm-ECGs in patients with LAA-thrombus and a propensity-score-matched control-cohort. Left atrial contractile function and thrombi were evaluated by transesophageal echocardiography (TEE). Outcome for MACCE including death was assessed using official registries and structured phone interviews. Left-atrial appendage [LAA]-thrombi and appropriate sinus rhythm-ECGs for ACM-staging were found in 109 of 4086 patients that were matched 1:1 to control patients without thrombus (218 patients in total). Both cohorts were comparable regarding cardiovascular risk factors, anticoagulants and CHA2DS2-VASC-score. ACM-stages 1 to 3 (equivalent to no, moderate and extensive ACM) were found in 63 (57.8%), 36 (33.0%) and 10 (9.2%) of patients without and 3 (2.8%), 23 (21.1%) and 83 (76.1%) of patients with LAA-thrombi. Atrial contractile function decreased from ACM-stages 1 to 3 (LAA-flow velocities 38 ± 16 cm/s, 31 ± 15 cm/s and 21 ± 12 cm/s; p < 0.0001), while the likelihood for LAA-thrombus increased (2.8%, 21.1% and 76.1%, p < 0.001). Multivariable analysis confirmed an independent odds ratio for LAA-thrombus of 24.6 (p < 0.001) per ACM-stage. Two-year survival free of stroke/TIA, hospitalization for heart failure, myocardial infarction or all-cause death was strongly reduced in ACM-stage 3 (53.8%) compared to no or moderate ACM (82.8% and 84.7%, respectively; p < 0.0001). Electrocardiographic diagnosis of ACM identifies patients with atrial contractile dysfunction and atrial thrombi at risk for adverse cardiovascular outcomes and death., (© 2022. The Author(s).)

Published
2022
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49. Non-invasive body surface electrocardiographic imaging for diagnosis of atrial cardiomyopathy.

Author

Eichenlaub M, Mueller-Edenborn B, Lehrmann H, Minners J, Nairn D, Loewe A, Allgeier J, Jander N, Allgeier M, Ruile P, Hein M, Rees F, Trenk D, Weber R, Neumann FJ, Arentz T, and Jadidi A

Subjects
Female, Humans, Male, Recurrence, Treatment Outcome, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Cardiomyopathies, Catheter Ablation adverse effects, Pulmonary Veins surgery
Abstract

Aims: Atrial cardiomyopathy (ACM) is associated with new-onset atrial fibrillation, arrhythmia recurrence after pulmonary vein isolation (PVI) and increased risk for stroke. At present, diagnosis of ACM is feasible by endocardial contact mapping of left atrial (LA) low-voltage substrate (LVS) or late gadolinium-enhanced magnetic resonance imaging, but their complexity limits a widespread use. The aim of this study was to assess non-invasive body surface electrocardiographic imaging (ECGI) as a novel clinical tool for diagnosis of ACM compared with endocardial mapping., Methods and Results: Thirty-nine consecutive patients (66 ± 9 years, 85% male) presenting for their first PVI for persistent atrial fibrillation underwent ECGI in sinus rhythm using a 252-electrode-array mapping system. Subsequently, high-density LA voltage and biatrial activation maps (mean 2090 ± 488 sites) were acquired in sinus rhythm prior to PVI. Freedom from arrhythmia recurrence was assessed within 12 months follow-up. Increased duration of total atrial conduction time (TACT) in ECGI was associated with both increased atrial activation time and extent of LA-LVS in endocardial contact mapping (r = 0.77 and r = 0.66, P < 0.0001 respectively). Atrial cardiomyopathy was found in 23 (59%) patients. A TACT value of 148 ms identified ACM with 91.3% sensitivity and 93.7% specificity. Arrhythmia recurrence occurred in 15 (38%) patients during a follow-up of 389 ± 55 days. Freedom from arrhythmia was significantly higher in patients with a TACT <148 ms compared with patients with a TACT ≥148 ms (82.4% vs. 45.5%, P = 0.019)., Conclusion: Analysis of TACT in non-invasive ECGI allows diagnosis of patients with ACM, which is associated with a significantly increased risk for arrhythmia recurrence following PVI., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.)

Published
2021
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50. Three-year outcome after transcatheter aortic valve implantation: Comparison of a restrictive versus a liberal strategy for pacemaker implantation.

Author

Schoechlin S, Minners J, Schulz U, Eichenlaub M, Ruile P, Neumann FJ, and Arentz T

Subjects
Aged, 80 and over, Arrhythmias, Cardiac epidemiology, Arrhythmias, Cardiac therapy, Female, Follow-Up Studies, Germany epidemiology, Humans, Incidence, Male, Retrospective Studies, Time Factors, Aortic Valve Stenosis surgery, Arrhythmias, Cardiac etiology, Pacemaker, Artificial, Quality of Life, Transcatheter Aortic Valve Replacement adverse effects
Abstract

Background: Conduction disturbances after transcatheter aortic valve implantation (TAVI) are common, heterogeneous, and frequently result in permanent pacemaker implantation (PPI). Pacemaker therapy with a high rate of right ventricular pacing is associated with heart failure, hospitalizations, and reduced quality of life., Objective: The purpose of this study was to compare medium-term outcomes between PPI implantation strategies, as choosing the right indication for PPI is still an area of uncertainty and information on outcomes of PPI regimens beyond 1 year is rare., Methods: We compared outcomes after 3 years between a restrictive PPI strategy, in which the lowest threshold for PPI was left bundle branch block (LBBB) (QRS >120 ms) with the presence of new atrioventricular block (PQ >200 ms), and a liberal PPI regimen, in which PPI already was performed in patients with new-onset LBBB., Results: Between January 2014 and December 2016, TAVI was performed in 884 patients at our center. Of these, 383 consecutive, pacemaker-naive patients underwent TAVI with the liberal PPI strategy and subsequently 384 with the restrictive strategy. The restrictive strategy significantly reduced the percentage of patients undergoing PPI before discharge (17.2% vs 38.1%; P <.001). The incidence of the primary endpoint (all-cause-mortality and hospitalization for heart failure) after 3 years was similar in both groups (30.7% vs 35.2%; P = .242), as was all-cause-mortality (26.6% vs 29.2%; P = .718). Overall, patients who required PPI post-TAVI had significantly more hospitalizations due to heart failure (14.8% vs 7.8%; P = .004)., Conclusion: A restrictive PPI strategy after TAVI reduces PPI significantly and is safe in medium-term follow-up over 3 years., (Copyright © 2021 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)

Published
2021
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