79 results on '"Minna Zhang"'
Search Results
2. B3GNT7 regulates mucin O-glycosylation to alleviate colonic inflammation
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Tian Wang, Han Sun, Minna Zhang, Peng Shen, and Yan Li
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Ulcerative colitis ,B3GNT7 ,Mucin ,O-glycosylation ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background B3GNT7, a glycosyltransferase of significant importance that is highly expressed in intestinal epithelial cells, plays a pivotal role in intestinal physiological processes. This study elucidates novel insights into the potential role and underlying mechanisms of B3GNT7 in ulcerative colitis (UC). Methods An experimental colitis model was induced using DSS in mice to investigate B3GNT7 expression in the colon via transcriptomics and immunohistochemistry. Bioinformatics analysis was employed to delineate the biological functions of B3GNT7. Additionally, the correlation between the transcription levels of B3GNT7 in colonic tissues from patients with UC, sourced from the IBDMDB database, and the severity of colonic inflammation was analyzed to elucidate potential mechanisms. Results The DSS-induced colitis model was successfully established, and transcriptomic analysis identified a marked downregulation of B3GNT7 expression in the colonic tissues compared to the controls. Functional enrichment analysis indicated B3GNT7’s predominant role in mucin O-glycosylation. Protein interaction analysis revealed that B3GNT7 predominantly interacts with members of the mucin MUC family, including MUC2, MUC3, and MUC6. In patients with UC, B3GNT7 transcription levels were significantly reduced, particularly in those with moderate to severe disease activity. The expression level of B3GNT7 exhibited a negative correlation with the endoscopic severity of UC. Gene set enrichment analysis (GSEA) further demonstrated significant enrichment of B3GNT7 in the mucin O-glycosylation synthesis pathway. Conclusion The downregulation of B3GNT7 expression in the colonic tissues of UC patients may contribute to the compromised mucin barrier function and the exacerbation of colitis.
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- 2024
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3. Report on the diagnosis and treatment of 3 cases of emphysematous pyelonephritis with two different outcomes
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Minna Zhang, Hongxing Luo, Su Tan, Tao Fei, Zhimin Tang, Qiang Li, and Haixing Lin
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emphysematous pyelonephritis ,urinary system infection ,microbiological culture ,nephrectomy ,case series ,Medicine (General) ,R5-920 - Abstract
BackgroundEmphysematous pyelonephritis (EPN) is a rare acute severe necrotising infection of the kidneys in clinical practice. It is characterized by the presence of gas in the renal parenchyma, collecting system, or perirenal tissue. The prognosis is poor, with a high nephrectomy rate and a mortality rate of up to 20–40%.MethodsRetrospective analysis of 3 cases of emphysematous pyelonephritis with two different outcomes.ResultsThree patients who we described were all female with diabetes mellitus, and their blood sugar was poorly controlled. One patient with the advanced age and poor general health died due to the patient’s family choosing to terminate therapy. Two patients underwent surgical procedures achieved an excellent clinical recovery. Both of them underwent percutaneous nephrostomy and perinephric abscess puncture drainage before nephrectomy. Escherichia coli were the microorganisms implicated.ConclusionEPN is a rare and severe urinary system infection. Computed tomography (CT) and microbiological culture confirmed the diagnosis. Control of diabetes, sensitive antibiotic therapy, fluid resuscitation and prompt surgical intervention are crucial.
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- 2024
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4. Advances in fecal microbiota transplantation for the treatment of diabetes mellitus
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Juan Zhang, Honggang Wang, Ying Liu, Min Shi, Minna Zhang, Hong Zhang, and Juan Chen
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fecal microbiota transplantation ,diabetes mellitus ,diabetes complications ,gastrointestinal microbiome ,metabolite ,metabolic disease ,Microbiology ,QR1-502 - Abstract
Diabetes mellitus (DM) refers to a group of chronic diseases with global prevalence, characterized by persistent hyperglycemia resulting from various etiologies. DM can harm various organ systems and lead to acute or chronic complications, which severely endanger human well-being. Traditional treatment mainly involves controlling blood sugar levels through replacement therapy with drugs and insulin; however, some patients still find a satisfactory curative effect difficult to achieve. Extensive research has demonstrated a close correlation between enteric dysbacteriosis and the pathogenesis of various types of DM, paving the way for novel therapeutic approaches targeting the gut microbiota to manage DM. Fecal microbiota transplantation (FMT), a method for re-establishing the intestinal microbiome balance, offers new possibilities for treating diabetes. This article provides a comprehensive review of the correlation between DM and the gut microbiota, as well as the current advancements in FMT treatment for DM, using FMT as an illustrative example. This study aims to offer novel perspectives and establish a theoretical foundation for the clinical diagnosis and management of DM.
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- 2024
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5. Experimental impacts of grazing on grassland biodiversity and function are explained by aridity
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Minna Zhang, Manuel Delgado-Baquerizo, Guangyin Li, Forest Isbell, Yue Wang, Yann Hautier, Yao Wang, Yingli Xiao, Jinting Cai, Xiaobin Pan, and Ling Wang
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Science - Abstract
Abstract Grazing by domestic herbivores is the most widespread land use on the planet, and also a major global change driver in grasslands. Yet, experimental evidence on the long-term impacts of livestock grazing on biodiversity and function is largely lacking. Here, we report results from a network of 10 experimental sites from paired grazed and ungrazed grasslands across an aridity gradient, including some of the largest remaining native grasslands on the planet. We show that aridity partly explains the responses of biodiversity and multifunctionality to long-term livestock grazing. Grazing greatly reduced biodiversity and multifunctionality in steppes with higher aridity, while had no effects in steppes with relatively lower aridity. Moreover, we found that long-term grazing further changed the capacity of above- and below-ground biodiversity to explain multifunctionality. Thus, while plant diversity was positively correlated with multifunctionality across grasslands with excluded livestock, soil biodiversity was positively correlated with multifunctionality across grazed grasslands. Together, our cross-site experiment reveals that the impacts of long-term grazing on biodiversity and function depend on aridity levels, with the more arid sites experiencing more negative impacts on biodiversity and ecosystem multifunctionality. We also highlight the fundamental importance of conserving soil biodiversity for protecting multifunctionality in widespread grazed grasslands.
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- 2023
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6. Exploring the alteration of gut microbiota and brain function in gender-specific Parkinson’s disease based on metagenomic sequencing
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Minna Zhang, Zhiyuan Zhai, Bo Yang, Le He, Jingyi Wang, Weijie Dai, Liujun Xue, Xiaozhong Yang, Yun Feng, and Honggang Wang
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Parkinson’s disease ,gut microbiota ,fMRI ,gender ,metagenomic sequencing ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
BackgroundThe role of the microbiota-gut-brain axis in Parkinson’s disease (PD) has received increasing attention. Although gender differences are known to an essential role in the epidemiology and clinical course of PD, there are no studies on the sex specificity of the microbiota-gut-brain axis in the development and progression of PD.MethodsFresh fecal samples from 24 PD patients (13 males, 11 females) were collected for metagenomic sequencing. The composition and function of the gut microbiota were analyzed by resting-state functional magnetic resonance imaging (fMRI). Gender-dependent differences in brain ALFF values and their correlation with microbiota were further analyzed.ResultsThe relative abundance of Propionivibrio, Thermosediminibacter, and Flavobacteriaceae_noname was increased in male PD patients. LEfse analysis showed that Verrucomicrobial, Akkermansiaceae, and Akkermansia were dominant in the males. In female patients, the relative abundance of Propionicicella was decreased and Escherichia, Escherichia_coli, and Lachnospiraceae were predominant. The expression of the sesquiterpenoid and triterpenoid biosynthesis pathways was increased in male PD patients and was statistically different from females. Compared to the Male PD patients, female patients showed decreased ALFF values in the left inferior parietal regions, and the relative abundance of Propionivibrio was positively correlated with the regional ALFF values.ConclusionOur study provides novel clinical evidence of the gender-specific relationship between gut microbiota alterations and brain function in PD patients, highlighting the critical role of the microbiota-gut-brain axis in gender differences in PD.
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- 2023
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7. Gut microbiota alterations in children and their relationship with primary immune thrombocytopenia
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Xiangyu Li, Minna Zhang, Le He, Jingfang Zhou, Peng Shen, Weijie Dai, Xiaozhong Yang, Yufang Yuan, Haiyan Zhu, and Honggang Wang
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primary immune thrombocytopenia ,children ,gut microbiota ,abundance ,diversity ,antiplatelet antibodies ,Pediatrics ,RJ1-570 - Abstract
IntroductionGut microbiota reportedly play a critical role in some autoimmune diseases by maintaining immune homeostasis. Only a few studies have examined the correlation between gut microbiota and the onset of primary immune thrombocytopenia (ITP), especially in children. The purpose of this study was to investigate changes in the composition and diversity of the fecal microbiota of children with ITP, as well as the correlation between such microbiota and the onset of ITP.MethodsTwenty-five children newly diagnosed with ITP and 16 healthy volunteers (controls) were selected for the study. Fresh stool samples were collected to identify changes in the composition and diversity of gut microbiota as well as for potential correlation analysis.ResultsIn ITP patients, the phyla that were most frequently encountered were Firmicutes (54.3%), followed by Actinobacteria (19.79%), Bacteriodetes (16.06%), and Proteobacteria (8.75%). The phyla that were predominantly found in the controls were, Firmicutes (45.84%), Actinobacteria (40.15%), Bacteriodetes (3.42%), and Proteobacteria (10.23%). Compared with those of the controls, the proportions of Firmicutes and Bacteriodetes in the gut microbiota of ITP patients were increased while the proportions of Actinobacteria and Proteobacteria were decreased. Furthermore, gut microbiota in ITP patients varied by age group, showed specific changes in diversity, and were correlated with antiplatelet antibodies. IgG levels were significantly positively correlated with Bacteroides (P
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- 2023
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8. Exploration of the shared pathways and common biomarker PAN3 in ankylosing spondylitis and ulcerative colitis using integrated bioinformatics analysis
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Minna Zhang, Junyi Zhou, Honggang Wang, Le He, Jingyi Wang, Xiaozhong Yang, and Xiaomin Zhong
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ulcerative colitis ,ankylosing spondylitis ,weighted gene co-expression network analysis ,mitogen-activated protein kinase ,PAN3 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundUlcerative colitis (UC) is a chronic autoimmune-related disease that causes inflammation of the intestine. Ankylosing spondylitis (AS) is a common extraintestinal complication of UC involving the sacroiliac joint. However, the pathogenesis of AS secondary to UC has not been studied. This study aimed to investigate the shared pathways and potential common biomarkers of UC and AS.MethodsMicroarray data downloaded from the Gene Expression Omnibus (GEO) database were used to screen differentially expressed genes (DEGs) in the UC and AS datasets. Weighted gene co-expression network analysis (WGCNA) was performed to identify co-expression modules related to UC and AS. Shared genes were then further analyzed for functional pathway enrichment. Next, the optimal common biomarker was selected using SVM-RFF and further validated using two independent GEO datasets. Finally, immune infiltration analysis was used to investigate the correlation of immune cell infiltration with common biomarkers in UC and AS.ResultsA total of 4428 and 2438 DEGs in UC and AS, respectively, were screened. Four modules were identified as significant for UC and AS using WGCNA. A total of 25 genes overlapped with the strongest positive and negative modules of UC and AS. KEGG analysis showed these genes may be involved in the mitogen-activated protein kinase (MAPK) signaling pathway. GO analysis indicated that these genes were significantly enriched for RNA localization. PAN3 was selected as the optimal common biomarker for UC and AS. Immune infiltration analysis showed that the expression of PAN3 was correlated with changes in immune cells.ConclusionThis study first explored the common pathways and genetic diagnostic markers involved in UC and AS using bioinformatic analysis. Results suggest that the MAPK signaling pathway may be associated with both pathogeneses and that PAN3 may be a potential diagnostic marker for patients with UC complicated by AS.
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- 2023
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9. Corrigendum: Nanostructured carbon electrocatalysts for clean energy conversion and storage: A mini review on the structural impact
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Mengqing Yang, Mengjie Wang, Minna Zhang, Xun Sun, and Xiaoxu Xuan
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carbon nanomaterials ,electrochemical ,water splitting ,ORR ,CO2RR ,NRR ,Technology - Published
- 2023
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10. Nanostructured carbon electrocatalysts for clean energy conversion and storage: A mini review on the structural impact
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Mengqing Yang, Mengjie Wang, Minna Zhang, Xun Sun, and Xiaoxu Xuan
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carbon nanomaterials ,electrochemical ,water splitting ,ORR ,CO2RR ,NRR ,Technology - Abstract
Electrochemical conversions of carbon dioxide, water, oxygen, and nitrogen have offered effective ways to relieve the problems of carbon dioxide over-emission and fluctuated energy (such as solar, wind, tide, etc.) storage. The key factor that impacts the electrochemical system’s performance is the catalysts employed. Among all the materials, carbon nanomaterials generally exhibit high catalytic activity which is attributed to the high conductivity, large specific surface area, and exposed active sites. Recently, more and more researchers set their sights on applying the carbon nanomaterials in large-scale projects. Herein, it is of great importance to review the most recent studies on carbon nanomaterials in electrochemical applications. This paper summarizes the applications of carbon nanomaterials in electrochemical processes, and the structure impact on the performance. Further, challenges in this field are discussed, which can guide the innovative synthesis of efficient nanostructured carbon electrocatalysts for practical, large-scale energy conversion applications.
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- 2022
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11. Lung adenocarcinoma relapse with emerging EGFR mutation following complete response of small cell lung cancer warrants routine re-biopsy: A case report
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Minna Zhang, Yi Tang, Junlei Wang, Qian Liu, and Bing Xia
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non-small cell lung cancer ,small cell lung cancer ,lung adenocarcinoma ,histological transformation ,EGFR ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Transformation of small cell lung cancer (SCLC) to lung adenocarcinoma (LUAD) is rarely reported. Here, we report a case initially presented with SCLC and was diagnosed as LUAD when the lesion relapsed at the same site. A 56-year-old patient with SCLC who received etoposide and cisplatin chemotherapy combined with radiotherapy achieved a complete radiological response. After 28 months of stable disease, a computed tomography scan revealed a new lesion at the same site as the primary tumor. Pathological examination suggested a LUAD with an emerging EGFR exon 19 deletion. The patient was then treated with icotinib and achieved a near-complete radiological response. Nineteen months later, the patient developed resistance caused by EGFR T790M mutation and received treatment with osimertinib. At the last follow-up in January 2022, the patient was symptom-free. This case warrants re-biopsy and genetic testing as a routine operation when SCLC relapses at the same site as the primary tumor for an extended period, and prospective investigation is required.
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- 2022
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12. Grassland degradation with saline-alkaline reduces more soil inorganic carbon than soil organic carbon storage
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Tongtong Xu, Minna Zhang, Shiwen Ding, Bai Liu, Qing Chang, Xuan Zhao, Ying Wang, Jianyong Wang, and Ling Wang
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Degraded grasslands ,Carbon stocks ,Soil organic carbon ,Soil inorganic carbon ,Profile distributions ,Soil salinization ,Ecology ,QH540-549.5 - Abstract
Grassland is an important part of terrestrial ecosystems and contain substantial amounts of soil carbon. However, 90% of grasslands suffer from degradation in northern China, where soil inorganic carbon (SIC) is a major reservoir. Previous studies have focused primarily on soil organic carbon (SOC) stock, while the effects of grassland degradation in SIC stock remains largely unexplored. Therefore, accurate assessments of both SOC and SIC stocks and their profile distributions are necessary to fully understand the role of grassland degradation in China’s carbon budget. Here, we conducted an experiment to estimate the stocks, profile distributions, and environmental controls of both SOC and SIC in patchy saline-alkaline grasslands under three degraded degrees (non-degraded patches, ND; moderately degraded patches, MD, and heavily degraded patches, HD). Our results showed that grassland degradation destroys not only SOC but also SIC stocks in saline-alkaline grasslands. SIC is the main component of soil carbon in saline-alkaline grasslands, and their distributions changed dramatically. Compared with ND, SIC losses caused by degradation accounted for 84% and 86% of total carbon loss under MD and HD patches, respectively. SIC loss primarily occurred at the intermediate soil layers (30–70 cm), while the loss of SOC was mainly in the topsoil (0–40 cm). Moreover, the distributions of SIC from 20 to 60 cm were closely related to soil pH, while it is mainly regulated by EC from 60 to 100 cm. In addition, soil pH, EC, and above-ground biomass were important variables driving the profile distributions of SOC in the upper soil. Our work provides evidence that grassland degradation mainly damages the SIC stocks. Our findings, therefore, highlight the non-negligible role of SIC dynamics in the carbon budget of degraded grassland ecosystems and the need to consider these dynamics in terrestrial carbon cycle research.
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- 2021
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13. Carbon Aerogels as Electrocatalysts for Sustainable Energy Applications: Recent Developments and Prospects
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Minna Zhang, Xiaoxu Xuan, Xibin Yi, Jinqiang Sun, Mengjie Wang, Yihao Nie, Jing Zhang, and Xun Sun
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carbon aerogels ,electrocatalysis ,sustainable energy applications ,Chemistry ,QD1-999 - Abstract
Carbon aerogel (CA) based materials have multiple advantages, including high porosity, tunable molecular structures, and environmental compatibility. Increasing interest, which has focused on CAs as electrocatalysts for sustainable applications including oxygen reduction reaction (ORR), oxygen evolution reaction (OER), hydrogen evolution reaction (HER), and CO2 reduction reaction (CO2RR) has recently been raised. However, a systematic review covering the most recent progress to boost CA-based electrocatalysts for ORR/OER/HER/CO2RR is now absent. To eliminate the gap, this critical review provides a timely and comprehensive summarization of the applications, synthesis methods, and principles. Furthermore, prospects for emerging synthesis, screening, and construction methods are outlined.
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- 2022
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14. Positive Correlation of Peripheral CD8+ T Lymphocytes with Immune-Related Adverse Events and Combinational Prognostic Value in Advanced Non-Small Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors
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Kan Wu, Bing Xia, Jing Zhang, Xin Li, Shaoyu Yang, Minna Zhang, Lucheng Zhu, Bing Wang, Xiao Xu, Shenglin Ma, and Xueqin Chen
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immune-related adverse events ,baseline peripheral CD8+ T lymphocytes ,non-small cell lung cancer ,prognostic ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Immune checkpoint inhibitors (ICIs) therapy has revolutionized the treatment patterns of non-small cell lung cancer (NSCLC). However, patients treated with ICIs may experience immune-related adverse events (irAEs). Markers that could predict the onset of irAEs are still unclear. Here, we report the possible correlation of baseline peripheral lymphocytes with irAEs and clinical outcomes in advanced NSCLC patients receiving ICIs. A total of 109 advanced NSCLC patients treated with ICIs from April 2017 to January 2021 were analyzed retrospectively. Logistic and Cox regression analyses was applied to evaluate independent risk factors for irAEs, progression-free survival (PFS), and overall survival (OS). Among these patients, 55 (50.5%) patients experienced irAEs. The level of CD8+ T lymphocytes at baseline was the independent risk factor for the onset of irAEs (p = 0.008). A higher level of CD8+ T lymphocytes was associated with longer PFS (11.0 months vs. 3.0 months, p < 0.001) and OS (27.9 months vs. 11.7 months, p = 0.014). Furthermore, patients who had higher baseline CD8+ T lymphocytes and experienced irAEs had a longer PFS (18.4 months vs. 2.2 months, p < 0.001) and OS (32.8 months vs. 9.0 months, p = 0.001) than those who had lower CD8+ T lymphocytes and no irAEs. Our study highlights the value of baseline peripheral CD8+ T lymphocytes as a predictive factor for irAEs in advanced NSCLC patients receiving ICIs. In addition, patients who have higher baseline CD8+ T lymphocytes and experience irAEs would have a superior PFS and OS.
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- 2022
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15. Identifying the active components of Baihe–Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests
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Ming Zhong, Xiaoting Tian, Shuoji Chen, Mingcang Chen, Ziqiong Guo, Minna Zhang, Gongpu Zheng, Zhixiong Li, Zhangpeng Shi, Guanghui Wang, Honggang Gao, Fang Liu, and Chenggang Huang
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Baihe–Zhimu decoction ,Antidepressant ,Timosaponin BII ,Timosaponin BIII ,Drug discovery ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Background Modern pharmacological studies have demonstrated that Baihe–Zhimu decoction (BZD) has antidepressant effects. However, the complex composition and lack of clear evaluation standards for BZD make it less likely to be understood and accepted than evidence-based active natural compounds. Methods In this study, an effective method for the identification of antidepressant components was demonstrated and applied to BZD. The first step was to evaluate the efficacy of BZD by the forced swimming test (FST) and the tail suspension test (TST), followed by successive quantitative analyses of the absorbed constituents at different stages, such as before hepatic disposition, liver distribution, after hepatic disposition and brain distribution after the oral administration of BZD. Finally, the compounds detected in the brain were confirmed by activity testing. Results Our investigation observed that timosaponin BII and timosaponin BIII were accurately determined in the brain after oral administration of BZD, and they were further confirmed to reduce the immobility time in the FST and TST. As described above, timosaponin BII and timosaponin BIII were used to scientifically and reasonably explain the effective chemical basis of the effect of BZD on depression. Conclusions This research affords an effective method to discover lead molecules for antidepressants from traditional Chinese medicine.
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- 2019
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16. Downregulation of SRPK2 promotes cell cycle arrest though E2F1 in non-small cell lung cancer
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Xin Li, Shaoyu Yang, Minna Zhang, Shuhuan Xie, and Zefeng Xie
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SRPK2 ,NSCLC ,E2F1 ,cell cycle ,Biology (General) ,QH301-705.5 - Abstract
Serine-arginine protein kinase (SRPK) belongs to a class of cell cycle regulating kinases that can phosphorylate proteins containing serine/arginine-Rich (SR) regions. SR proteins are a family of RNA binding phosphoproteins that control both constitutive and alternative pre-mRNA splicing events. However, little is known about their role in non-small cell lung cancer (NSCLC). In the present study, we found that serine-arginine protein kinase 2 (SRPK2) expression was upregulated in NSCLC tissues compared with adjacent normal tissues. Kaplan-Meier curve analyses showed that the overall survival time of NSCLC patients with high SRPK2 expression was shorter than those with low SRPK2 expression. Overexpression of SRPK2 promoted NSCLC cell proliferation and cell cycle arrest, while knockdown of SRPK2 inhibited proliferation and promoted cell cycle arrest in NSCLC cell lines. SRPK2 promoted the transcriptional regulation of E2F1 on downstream cell cycle related genes through phosphorylation of SC35. Xenograft model showed that SRPK2 promoted tumor growth in vivo. SRPK2 phosphorylated SC35 and phosphorylated SC35 activated E2F1 transcription of cyclin-related proteins, thereby promoting the cycle progression of NSCLC. Our findings demonstrated that SRPK2 may be a potential therapeutic target for NSCLC clinical therapy, which plays an important role in the progression of NSCLC.
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- 2019
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17. Correction to: Identifying the active components of Baihe–Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests
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Ming Zhong, Xiaoting Tian, Shuoji Chen, Mingcang Chen, Ziqiong Guo, Minna Zhang, Gongpu Zheng, Zhixiong Li, Zhangpeng Shi, Guanghui Wang, Honggang Gao, Fang Liu, and Chenggang Huang
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Other systems of medicine ,RZ201-999 - Abstract
In the original publication of this article [1], another affiliation (Affiliation 3: University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China.) for the author Ziqiong Guo is missing due to the carelessness during the author proof. In addition, in Affiliation 2 “Chinese Academy of Science” should be changed to “Chinese Academy of Sciences”.
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- 2020
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18. Ascorbic Acid Alleviates Damage from Heat Stress in the Photosystem II of Tall Fescue in Both the Photochemical and Thermal Phases
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Ke Chen, Minna Zhang, Huihui Zhu, Meiyu Huang, Qing Zhu, Diyong Tang, Xiaole Han, Jinlin Li, Jie Sun, and Jinmin Fu
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L-ascorbate ,heat stress ,tall fescue ,photochemical phase ,thermal phase ,Plant culture ,SB1-1110 - Abstract
L-Ascorbate (Asc) plays important roles in plant development, hormone signaling, the cell cycle and cellular redox system, etc. The higher content of Asc in plant chloroplasts indicates its important role in the photosystem. The objective of this study was to study the roles of Asc in tall fescue leaves against heat stress. After a heat stress treatment, we observed a lower value of the maximum quantum yield for primary photochemistry (φPo), which reflects the inhibited activity of the photochemical phase of photosystem II (PSII). Moreover, we observed a higher value of efficiency of electron transfer from QB to photosystem I acceptors (δR0), which reflects elevated activity of the thermal phase of the photosystem of the tall fescue. The addition of Asc facilitate the behavior of the photochemical phase of the PSII by lowering the ROS content as well as that of the alternative electron donor to provide electron to the tyrosine residue of the D1 protein. Additionally, exogenous Asc reduces the activity of the thermal phase of the photosystem, which could contribute to the limitation of energy input into the photosystem in tall fescue against heat stress. Synthesis of the Asc increased under heat stress treatment. However, under heat stress this regulation does not occur at the transcription level and requires further study.
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- 2017
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19. Preparation and Antioxidant Activity of Ethyl-Linked Anthocyanin-Flavanol Pigments from Model Wine Solutions
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Lingxi Li, Minna Zhang, Shuting Zhang, Yan Cui, and Baoshan Sun
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anthocyanin ,antioxidant activity ,ethyl-linked anthocyanin-flavanol pigment ,Organic chemistry ,QD241-441 - Abstract
Anthocyanin-flavanol pigments, formed during red wine fermentation and storage by condensation reactions between anthocyanins and flavanols (monomers, oligomers, and polymers), are one of the major groups of polyphenols in aged red wine. However, knowledge of their biological activities is lacking. This is probably due to the structural diversity and complexity of these molecules, which makes the large-scale separation and isolation of the individual compounds very difficult, thus restricting their further study. In this study, anthocyanins (i.e., malvidin-3-glucoside, cyanidin-3-glucoside, and peonidin-3-glucoside) and (–)-epicatechin were first isolated at a preparative scale by high-speed counter-current chromatography. The condensation reaction between each of the isolated anthocyanins and (–)-epicatechin, mediated by acetaldehyde, was conducted in model wine solutions to obtain ethyl-linked anthocyanin-flavanol pigments. The effects of pH, molar ratio, and temperature on the reaction rate were investigated, and the reaction conditions of pH 1.7, molar ratio 1:6:10 (anthocyanin/(–)-epicatechin/acetaldehyde), and reaction temperature of 35 °C were identified as optimal for conversion of anthocyanins to ethyl-linked anthocyanin-flavanol pigments. Six ethyl-linked anthocyanin-flavanol pigments were isolated in larger quantities and collected under optimal reaction conditions, and their chemical structures were identified by HPLC-QTOF-MS and ECD analyses. Furthermore, DPPH, ABTS, and FRAP assays indicate that ethyl-linked anthocyanin-flavanol pigments show stronger antioxidant activities than their precursor anthocyanins.
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- 2018
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20. Directional porous polyimide/polyethylene glycol composite aerogel with enhanced CO2 uptake performance
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Yihao Nie, Xibin Yi, Xinfu Zhao, Shimo Yu, Jing Zhang, Xiaochan Liu, Sijia Liu, Zhipeng Yuan, and Minna Zhang
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Polymers and Plastics ,Organic Chemistry ,Materials Chemistry - Abstract
The cost of CO2 separation and energy consumption can be decreased through the use of CO2 adsorption. Due to the electron-rich heteroatoms in its network, polyimide (PI) has a remarkable affinity for CO2. Polyethylene glycol (PEG) can increase the layer spacing of polymers, so as to change the mass transfer of CO2 in it. Furthermore, the ether bond (-O-) in PEG has good affinity for CO2. In this study, PEG-1000 was introduced into PI aerogel by mild sol-gel method at low temperature, and freeze-drying was used to produce PI/PEG composite aerogels with directional pore structure. The effect of PEG-1000 content and directional pore structure of the PI/PEG composite aerogels on CO2 adsorption performance were further studied. The L-PI/PEG-4 composite aerogel, which contains 4 g PEG and is directionally frozen in liquid nitrogen, has a CO2 adsorption capacity of 16.76 cm3/g at 25°C and 1 bar. L-PI/PEG-4 aerogel also exhibits high CO2/N2 selectivity and adsorption cycle stability.
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- 2022
21. Changes in plant community assembly from patchy degradation of grasslands and grazing by different‐sized herbivores
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Yueqing, Song, Man, Xu, Tongtong, Xu, Xuan, Zhao, Yonghuan, Yue, Haoran, Yu, Minna, Zhang, and Ling, Wang
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Ecology - Abstract
Grassland degradation caused by increases in livestock grazing threatens a variety of ecosystem services. Understanding changes in plant community assembly during the process of grassland degradation in the presence of grazing is important to help restore degraded grasslands worldwide but has received little attention thus far. The grassland degradation process is typified by heterogeneous degradation, i.e., gradual formation of degraded patches (hereafter "patchy degradation"). Here, we experimentally examined the effects of herbivore grazing and patchy degradation on plant community assembly using nine pairs of non-degraded (intact) and patch-degraded (fragmented) grasslands subject to grazing by different-sized herbivores (i.e., NG, no grazing; SG, sheep grazing; CG, cattle grazing) over four years. Using a null-model approach, we estimated the relative magnitude of deterministic processes of community assembly by comparing the observed and expected β-diversity. We found that in the absence of herbivore grazing, deterministic processes played a greater role in community assembly, regardless of whether patchy degradation had occurred. However, the deterministic processes resulted in plant communities being more spatially similar in non-degraded grasslands while being more dissimilar in patchy degraded grasslands. Compared with non-degraded grasslands, species with strong competitive abilities (i.e., Leymus chinensis) were less dominant in patchy degraded grasslands, indicating relaxed competition and a reduced role of species interactions over plant communities. Instead, patchy degradation added the role of environmental variables over plant communities. Sheep grazing consistently promoted more stochastic plant community assembly in both non-degraded and patch-degraded grasslands, while cattle grazing promoted more stochastic plant community assembly only in the non-degraded state, having no effect in the patch-degraded state. Our study offers important insights into changes in plant community assembly during ongoing patch-degradation of grasslands, indicating the role of increased environmental filtering of soil and reduced species interactions in driving plant community dynamics with increasing grassland patchy degradation. We also uncovered an herbivore species-specific effect on plant community assembly during the process of grassland degradation, which will better inform and improve future grassland restoration planning efforts. This article is protected by copyright. All rights reserved.
- Published
- 2023
22. Herbivore grazing mitigates the negative effects of nitrogen deposition on soil organic carbon in low‐diversity grassland
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Shicheng Jiang, Xiaobin Pan, Jinting Cai, Minna Zhang, Xuxin Song, Jinyan Sun, Guangyin Li, Ling Wang, and Duofeng Pan
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Nitrogen deposition ,Herbivore ,geography ,geography.geographical_feature_category ,Ecology ,Agronomy ,Grazing ,Grassland management ,Environmental science ,Soil carbon ,Grassland ,Diversity (business) ,Carbon cycle - Published
- 2021
23. The relative and combined effects of herbivore assemblage and soil nitrogen on plant diversity
- Author
-
Ling Wang, Yingying Kuang, Guangyin Li, Bai Liu, Minna Zhang, Shicheng Jiang, Xiuquan Yue, and Jushan Liu
- Subjects
Cattle grazing ,geography ,Herbivore ,Sheep ,geography.geographical_feature_category ,Nitrogen ,Soil nitrogen ,Plants ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Grassland ,Soil ,Soil resources ,Agronomy ,Grazing ,Animals ,Assemblage (archaeology) ,Cattle ,Herbivory ,General Agricultural and Biological Sciences ,Ecosystem ,General Environmental Science ,Plant diversity - Abstract
Plant diversity can be affected by both herbivore grazing and soil resources. However, it is unclear if the joint effects of herbivores and soil resources might vary with components of plant diversity. Here, we evaluated the relative and combined effects of herbivore assemblage and soil nitrogen (N) quantity and heterogeneity on the α and β components of plant diversity in a grassland that was subjected to four years of grazing under differing herbivore assemblages (no grazing, cattle grazing, sheep grazing, and mixed grazing). We found that herbivore assemblage combined with soil N quantity explained 41% of the variation in plant α-diversity, while herbivore assemblage combined with soil N heterogeneity explained 15% of the variation in plant β-diversity. The independent effects of herbivore assemblage explained more than those of soil N for both α- and β-diversity (α-diversity: 12% vs. 4%; β-diversity: 18% vs. 16%). We concluded that the effects of herbivores are stronger than those of soil N, and that grazing-induced changes in soil resources are important drivers of plant diversity change, especially α-diversity. Therefore, we suggest that managing herbivore species by accounting for the effects that their grazing can have on soil resources may be significant for plant diversity maintenance.
- Published
- 2021
24. The S40 family members delay leaf senescence by promoting cytokinin synthesis
- Author
-
Tianrui Yang, Minna Zhang, Qi Yang, Kun Liu, Jiaming Cui, Jia Chen, Yufan Ren, Yunjie Shao, Ruigang Wang, and Guojing Li
- Subjects
Plant Leaves ,Cytokinins ,Physiology ,Arabidopsis Proteins ,Gene Expression Regulation, Plant ,Genetics ,Arabidopsis ,Plant Science ,Plants, Genetically Modified ,Hormones ,Phylogeny ,Plant Senescence - Abstract
Leaf senescence is regulated by both endogenous hormones and environmental stimuli in a programmed and concerted way. The members of the S40 family have been reported to play roles in leaf senescence. Here we identified an S40 family member, CiS40-11, from Caragana intermedia. Phylogenetic analysis revealed that the CiS40-11 protein had the highest identity with AtS40-5 (AT1G11700) and AtS40-6 (AT1G61930) of Arabidopsis thaliana. CiS40-11 was highly expressed in leaves and was down-regulated after dark treatment. The subcellular localization analysis showed that CiS40-11 was a cytoplasm-nucleus dual-localized protein. Leaf senescence was delayed in both the CiS40-11 overexpressed A. thaliana and its transiently expressed C. intermedia. Transcriptomic analysis and endogenous hormones assay revealed that CiS40-11 inhibited leaf senescence via promoting the biosynthesis of cytokinins by blocking AtMYB2 expression in the CiS40-11 overexpression lines. Furthermore, overexpression of either AtS40-5 or AtS40-6 showed similar phenotype as the CiS40-11 overexpressing lines, while in the ats40-5a or ats40-6a mutants, the AtMYB2 expression was increased and their leaves exhibited a premature senescence phenotype. These results provide a new molecular mechanism of the S40 family in leaf senescence regulation of plants.
- Published
- 2022
25. Spatial effects of nitrogen deposition on soil organic carbon stocks in patchy degraded saline-alkaline grassland
- Author
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Tongtong Xu, Man Xu, Minna Zhang, Mike Letnic, Jianyong Wang, and Ling Wang
- Subjects
Soil Science - Published
- 2023
26. Qualitative and quantitative analysis of phenolic compounds in blueberries and protective effects on hydrogen peroxide‐induced cell injury
- Author
-
Baoshan Sun, Lingxi Li, Limin Wu, Shuting Zhang, Fang Wang, Chen Wang, and Minna Zhang
- Subjects
Flavonols ,030309 nutrition & dietetics ,Blueberry Plants ,Liquid-Liquid Extraction ,Filtration and Separation ,Mass spectrometry ,Orbitrap ,PC12 Cells ,01 natural sciences ,Analytical Chemistry ,law.invention ,Anthocyanins ,03 medical and health sciences ,chemistry.chemical_compound ,Phenols ,Tandem Mass Spectrometry ,law ,Hydroxybenzoates ,Animals ,Hydrogen peroxide ,Chromatography, High Pressure Liquid ,Flavonoids ,chemistry.chemical_classification ,0303 health sciences ,Chromatography ,Ethanol ,Plant Extracts ,Chemistry ,Glutathione peroxidase ,010401 analytical chemistry ,Rats ,0104 chemical sciences ,Oxidative Stress ,Proanthocyanidin ,Fruit ,Solvents ,Quantitative analysis (chemistry) - Abstract
This work was conducted to optimize an accelerated solvent extraction for ultra high performance liquid chromatography-mass spectrometry/mass spectrometry analysis of blueberry phenolic compounds. The conditions for accelerated solvent extraction were verified using response surface methodology to obtain the following optimized conditions: ethanol concentration (pH = 3), 48%; temperature, 50℃, and static cycle times, 3. Further, ultra high performance liquid chromatography with quadrupole Exactive Orbitrap mass spectrometry and ultra high performance liquid chromatography with triple-quadrupole tandem mass methods for determination of the detailed phenolic composition were developed and validated. Total of 81 phenolic compounds were identified by ultra high performance liquid chromatography with quadrupole Exactive Orbitrap mass spectrometry including 23 anthocyanins, 32 flavonols, 11 proanthocyanidins, 2 other flavonoids, and 13 phenolic acids. Fifty-one of these compounds have been simultaneously quantified by ultra high performance liquid chromatography with triple-quadrupole tandem mass including 31 anthocyanins, 8 flavonols, 6 proanthocyanidins, 2 other flavonoids, and 8 phenolic acids. Malvidin-dinhexoside has, for the first time, been detected in wild. Moreover, by verifying the protection on PC12 cells against oxidative damage, it was showed that the phenolic extracts (500 µg/mL) can improve significantly the viability (9.26-24.78%) of hydrogen peroxide-induced PC12 cells, activities of superoxide dismutase (34.59-37.90 U/mg) and glutathione peroxidase (6.87-14.42 mU/mg) and decrease the content of malonic dialdehyde (13.27-24.62 nmol/mg). Correlation analysis suggested that anthocyanins might contribute most to these activities.
- Published
- 2021
27. A scientific basis for promoting grassland ecosystemmultifunctionality by diversifying grazing livestock: A review
- Author
-
Deli Wang, Minna Zhang, Man Xu, and Ling Wang
- Subjects
Herbivore ,geography ,Multidisciplinary ,geography.geographical_feature_category ,business.industry ,Ecology ,Biodiversity ,Biology ,Grassland ,Grazing ,Biological dispersal ,Livestock ,Ecosystem ,Terrestrial ecosystem ,business - Abstract
The grassland is the largest terrestrial ecosystem in the world. How to manage and maintain grassland ecosystem functionality is becoming a critical issue as grasslands face serious degradation under the increasing pressures of global change. Livestock grazing is one such pressure, and it is the most widespread land use on Earth. Here, we explore theories and empirical evidence regarding how diversifying grazing livestock species and breeds could potentially improve grassland ecosystem multifunctionality. First, livestock grazing has been known to affect grassland multitrophic biodiversity, and thereby ecosystem multifunctionality. Different livestock species, such as cattle and sheep, vary in their foraging mode, diet, trampling effect and movement as well as in the quantity, distribution, and chemical composition of their excreta deposited in grasslands. As a result, diversity in livestock grazers leads to a variety of disturbances, higher landscape heterogeneity and more varied niches for plants, insects and soil organisms to inhabit. Therefore, diversity in grazers promotes higher overall ecosystem biodiversity. Second, livestock is an important dispersal agent for plants because they reduce intraspecific competition, minimize loss of genetic diversity and mitigate inbreeding. This leads to a more viable and diverse plant population. Third, diverse livestock species in natural grassland ecosystems may ecologically replace large-bodied and extinct native herbivores, and they certainly directly increase herbivore diversity, in grassland ecosystems. Finally, when a variety of livestock species or breeds grazes in the same grassland, it can lead to complex multi-species interactions. These interactions can be attributed to different nutritional demands and selections, and they thus greatly enhance trophic complexity and ecosystem functioning. At its core, the theory of diversifying livestock grazing aims to choose herbivores with different morphological, physiological or behavioral characteristics to thereby exert diverse disturbance on grasslands, rather than a single stressor. These diversified groups of livestock could comprise animal species of different functional groups, such as grazers and browsers, different species of the same functional group, or even different breeds of the same species. The greater the morphological, physiological and behavioral differences among livestock, the more sustainable is the grazing. Further, this diversity can also be created by adjusting the relative abundance of each species or variety, or by adopting one of two grazing modes; where all livestock graze in the same grassland at the same time (i.e., mixed grazing), or at different times (i.e., alternate grazing). In conclusion, altering livestock species composition and grazing intensity may improve grassland ecosystem functioning. We suggest that the ecological effects of grazing by diversifying livestock species and breeds should be empirically tested across different grassland types worldwide, and each specific mode of diversifying livestock grazing should be explored in turn. Future studies should test the following key questions: (1) Can altering the proportion or grazing sequence of different livestock species help achieve optimal grazing by multiple livestock species? (2) How do introduced diverse livestock interact with native herbivores? (3) Can diverse livestock be used as a long-term ecological substitute for large wild herbivores to maintain grassland ecosystem functioning?
- Published
- 2021
28. Land use intensification alters the relative contributions of plant functional diversity and soil properties on grassland productivity
- Author
-
Minna Zhang, Guangyin Li, Yue Wang, Duofeng Pan, Jinyan Sun, and Ling Wang
- Subjects
Ecology, Evolution, Behavior and Systematics - Abstract
Understanding the mechanisms of grassland productivity variation is critical for global carbon cycling and climate change mitigation. Heretofore, it is unknown how different environmental factors drive small-scale spatial variation in productivity, and whether land use intensification, one of the most important global changes, can regulate the processes that drive productivity change. Here we performed an 18-year exclosure experiment across six sites with high-intensity mowing/grazing history in northern China to examine the effects of land use intensification on plant functional diversity, soil properties, and their relative contributions to above-ground net primary productivity (ANPP). We found that plant functional diversity and soil properties contributed to the variation in ANPP both independently and equally in enclosed grasslands (plant diversity: 20.6%; soil properties: 19.5%). Intensive land use significantly decreased the Rao's quadratic entropy (RaoQ) and community-weighted mean value (CWM) of plant height, and further suppressed the contributions of plant functional diversity to ANPP. In contrast, intensive land use increased soil available N, P, pH, electrical conductivity, and homogeneity of soil available P, and strengthened their contributions to ANPP (31.5%). Our results indicate that high-intensity land use practices in grasslands decrease the role of plant functional diversity, but strengthen the effects of soil properties on productivity. We, therefore, suggest that plant functional diversity can be used effectively to boost productivity in undisturbed grasslands, while soil properties might be a more critical consideration for grassland management in an areas with increased land use.
- Published
- 2022
29. The senescence regulator S40 family members from Caragana intermedia and Arabidopsis thaliana inhibit leaf senescence via promoting cytokinins synthesis
- Author
-
Tianrui Yang, Minna Zhang, Qi Yang, Kun Liu, Jiaming Cui, Jia Chen, Yufan Ren, Yunjie Shao, Ruigang Wang, and Guojing Li
- Abstract
Leaf senescence is regulated by both endogenous hormones and environmental stimuli in a programmed and concerted way. The members of the S40 family have been reported to play roles in leaf senescence. Here we report that overexpression of an S40 family member from Caragana intermedia, CiS40-11, delayed the leaf senescence. Phylogenetic analysis revealed that the CiS40-11 protein had the highest identity with AtS40-5 and AtS40-6 of A. thaliana. CiS40-11 was highly expressed in leaves and was down-regulated after dark treatment. The subcellular localization analysis showed that CiS40-11 was a cytoplasm-nucleus dual-localized protein. Leaf senescence was delayed in CiS40-11 transgenic A. thaliana or by its transient expression in C. intermedia. Transcriptomic analysis and endogenous hormones assay revealed that CiS40-11 inhibited leaf senescence via promoting the biosynthesis of cytokinins, through blocking AtMYB2 expression in CiS40-11 overexpression lines. Furthermore, in the ats40-5a and ats40-6a mutants, AtMYB2 expression was increased and their leaves exhibited a premature senescence phenotype. Our results show that CiS40-11 (and its orthologs, AtS40-5 and AtS40-6) promoted cytokinin synthesis by inhibiting the expression of MYB2 and releasing its negative regulation on the expression of IPTs to inhabit leaf senescence.HighlightThe senescence regulator S40 family members CiS40-11, AtS40-5 and AtS40-6 are induced by light and inhibition leaf senescence by promoting cytokinin synthesis.
- Published
- 2022
30. N, O co-doped carbon aerogel derived from sodium alginate/melamine composite for all-solid-state supercapacitor
- Author
-
Jinqiang Sun, Jing Zhang, Mengge Shang, Minna Zhang, Xinfu Zhao, Sijia Liu, Xiaochan Liu, Shuo Liu, and Xibin Yi
- Subjects
General Physics and Astronomy ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films - Published
- 2023
31. Konjac glucomannan/cellulose nanofibers composite aerogel supported HKUST-1 for CO
- Author
-
Jinqiang, Sun, Mengge, Shang, Minna, Zhang, Shimo, Yu, Zhipeng, Yuan, Xibin, Yi, Serguei, Filatov, and Jing, Zhang
- Subjects
Mannans ,Nanofibers ,Adsorption ,Carbon Dioxide ,Cellulose ,Metal-Organic Frameworks - Abstract
Biomass aerogels are attractive in various applications owing to their inherent advantages of renewability, biodegradability and eco-friendly. Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials. The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO
- Published
- 2022
32. Nitrogen Deposition Does Not Mitigate Soil Carbon Loss in Patchy Degraded Saline-Alkaline Grassland
- Author
-
Tongtong Xu, Man Xu, Minna Zhang, Mike Letnic, Jianyong Wang, and Ling Wang
- Published
- 2022
33. Polybrominated diphenyl ethers in soils from Tianjin, North China: distribution, health risk, and temporal trends
- Author
-
Shan Ren, Yu Han, Zhenwu Tang, Minna Zhang, Xiangyang Xing, Jiazheng Sun, Jiali Cheng, and Lei He
- Subjects
Pollution ,endocrine system ,Environmental Engineering ,010504 meteorology & atmospheric sciences ,media_common.quotation_subject ,North china ,Distribution (economics) ,010501 environmental sciences ,01 natural sciences ,Polybrominated diphenyl ethers ,Geochemistry and Petrology ,Environmental Chemistry ,Health risk ,reproductive and urinary physiology ,0105 earth and related environmental sciences ,General Environmental Science ,Water Science and Technology ,media_common ,business.industry ,General Medicine ,humanities ,Congener ,Global distribution ,Environmental chemistry ,Soil water ,Environmental science ,business - Abstract
Available information is still insufficient for a comprehensive understanding of the global distribution of polybrominated diphenyl ethers (PBDEs) in the environment. In particular, little is known about the changing trend of their distribution in urban soils. We conducted a survey of 21 PBDEs in urban soils from Tianjin, China. The chemicals were widely present in the area and summed concentrations ranged from 0.65 to 108 ng/g in soil, indicating low to moderate levels of pollution relative to other areas. BDE-209 was the predominant congener, contributing 88.9% of the concentrations of total soil PBDEs. Source assessment indicated that soil PBDEs in the area were mainly derived from the release of commercial deca-BDE from local industrial production processes and consumer products. We found that the soil concentrations of PBDEs appear to have declined in recent years, compared with other previous reports in this region. However, more studies are needed on this possible change trend of PBDE pollution, especially its impact on human health, although their calculated non-carcinogenic health risks in this study were low.
- Published
- 2020
34. Effects of herbivore assemblage on the spatial heterogeneity of soil nitrogen in eastern Eurasian steppe
- Author
-
Jushan Liu, Minna Zhang, Deli Wang, Bai Liu, Guangyin Li, and Ling Wang
- Subjects
Cattle grazing ,Herbivore ,geography ,geography.geographical_feature_category ,Ecology ,Steppe ,Soil nitrogen ,Assemblage (archaeology) ,Precipitation ,Biology ,Spatial heterogeneity - Published
- 2020
35. Livestock overgrazing disrupts the positive associations between soil biodiversity and nitrogen availability
- Author
-
Cunzhu Liang, Guodong Han, Qing Chang, Jinting Cai, Zhiqiang Li, Jushan Liu, Yueqing Song, Ling Wang, Manuel Delgado-Baquerizo, Hui Zhu, Minna Zhang, Chengjie Wang, Deli Wang, Ying Chen, Xuan Zhao, and Xiaoping Xin
- Subjects
Soil biodiversity ,business.industry ,Agroforestry ,Livestock ,Biology ,Overgrazing ,business ,Ecology, Evolution, Behavior and Systematics - Published
- 2020
36. [Advances in fecal microbiota transplantation for treatment of Parkinson's disease]
- Author
-
Minna, Zhang, Honggang, Wang, Liujun, Xue, and Xiaozhong, Yang
- Subjects
Humans ,Neurodegenerative Diseases ,Parkinson Disease ,Fecal Microbiota Transplantation ,Middle Aged ,Aged ,Gastrointestinal Microbiome - Abstract
Parkinson's disease (PD) is a common neurodegenerative disease in middle-aged and elderly people. Patients with PD often suffer from gastrointestinal symptoms in the early stage of the disease. Several studies have confirmed that gut microbiota is involved in the progress of PD. As one of the most effective ways to reconstruct the gut microbiota, fecal microbiota transplantation (FMT) has shown potential therapeutic effects on PD. This review summarizes the basic and clinical studies of FMT in the treatment of PD.
- Published
- 2021
37. Glabridin attenuates atopic dermatitis progression through downregulating the TLR4/MyD88/NF-κB signaling pathway
- Author
-
Zengjiao Lai, Jing Chang, Lin Wang, and Minna Zhang
- Subjects
Lipopolysaccharides ,0106 biological sciences ,0301 basic medicine ,Interleukin-1beta ,Cell ,Biology ,01 natural sciences ,Biochemistry ,Dermatitis, Atopic ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,Phenols ,Western blot ,Genetics ,medicine ,Animals ,Humans ,Viability assay ,Molecular Biology ,medicine.diagnostic_test ,Interleukin-6 ,Cell growth ,NF-kappa B ,Transcription Factor RelA ,Isoflavones ,Toll-Like Receptor 4 ,Disease Models, Animal ,HaCaT ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Myeloid Differentiation Factor 88 ,Cancer research ,TLR4 ,Signal transduction ,Glabridin ,Signal Transduction ,010606 plant biology & botany - Abstract
Glabridin (GB), a bio-available phytoestrogen, displays various biological properties such as anti-inflammatory, antibacterial, and antiviral. To explore the role of GB in the process of atopic dermatitis (AD). CCK8 was used to detect the therapeutic effect of Glabridin in HaCat and NHEK cell inflammatory models. And evaluated the effect on cell proliferation and cell viability. The expression of TLR4, MyD88, P65 and P50 in HaCat and NHEK cell tissues was detected by qRT-PCR and PCR. At the same time, an AD animal model was constructed, and the cell experiment results were verified by hematoxylin–eosin (HE) and Immunohistochemistry staining (IHC). Enzyme-linked immunosorbent assay (ELISA) demonstrated that IL-1β, IL-6, and TNF-α upregulated by lipopolysaccharide (LPS) was decreased by treatment with GB. AD progression was further confirmed to be regulated by GB by inhibiting the TLR4/MyD88/NF-κB signaling pathway through real-time PCR and Western blot analyses. An AD-like mouse model demonstrated that GB considerably alleviated epidermal injury, relieve edema, and reduced inflammatory cell infiltration by H&E staining. Concurrently, IHC staining exhibited GB to reduce AD progression by impeding TLR4 expression. GB was observed to decrease the AD progression by suppressing the TLR4/MyD88/NF-κB signaling pathway, which may likely serve as a novel therapeutic drug for AD management.
- Published
- 2021
38. Heavy metals in soil contaminated through e-waste processing activities in a recycling area: Implications for risk management
- Author
-
Minna Zhang, Jiali Cheng, Zhenwu Tang, Xiangyang Xing, Yu Han, and Jiazheng Sun
- Subjects
Pollution ,021110 strategic, defence & security studies ,Environmental Engineering ,business.industry ,General Chemical Engineering ,media_common.quotation_subject ,0211 other engineering and technologies ,Background concentrations ,Heavy metals ,02 engineering and technology ,010501 environmental sciences ,Contamination ,Metal pollution ,01 natural sciences ,Environmental protection ,Environmental Chemistry ,Environmental science ,Safety, Risk, Reliability and Quality ,business ,Risk management ,0105 earth and related environmental sciences ,Waste processing ,Abandoned site ,media_common - Abstract
Heavy metal pollution of the environment caused by e-waste recycling is of increasing concern, but little information is available on metal emissions during e-waste processing activities. Here, the concentrations of nine metals in soil at four contaminated sites in Qingyuan (an e-waste recycling area in China) and the risks posed were investigated. Soil at the sites was polluted with metals, particularly Cd, Cu, Pb, and Sb, the concentrations of which were 2.83–2306, 2.17–1880, 0.96–1971, and 9.28–5607 times higher, respectively, than local background concentrations. The Cd, Cr, Hg, Pb, and Sb concentrations were significantly lower in soil at an abandoned site than at acid-leaching, dismantling, and burning sites. The risks posed by metals in soil to human and environmental health were much higher at the acid-leaching and burning sites than the dismantling and abandoned sites. Source assessments indicated the differences in metal concentrations at the different sites were caused by different e-waste recycling activities at the sites. The results indicated crude e-waste processing is an important source of heavy metals to soil and should be of great concern. Pollution control measures and risk management strategies specific to soil contaminated through e-waste processing activities should be developed.
- Published
- 2019
39. P42.04 Prognosis Factors in Advanced Lung Cancer Patients Treated With Checkpoint Inhibitor-Based Immunotherapy
- Author
-
Bing Xia, Kan Wu, Shenglin Ma, X. Chen, Lucheng Zhu, Bo Wang, and Minna Zhang
- Subjects
Pulmonary and Respiratory Medicine ,Oncology ,business.industry ,Immune checkpoint inhibitors ,medicine.medical_treatment ,medicine ,Cancer research ,Immunotherapy ,Lung cancer ,medicine.disease ,business - Published
- 2021
40. Radiation pneumonitis in lung cancer treated with volumetric modulated arc therapy
- Author
-
Kan Wu, Jiahao Wang, Minna Zhang, Lucheng Zhu, Bing Wang, Xiao Xu, Shenglin Ma, Xiadong Li, Bing Xia, and Xueqin Chen
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Multivariate analysis ,Lung ,business.industry ,Incidence (epidemiology) ,Urology ,Common Terminology Criteria for Adverse Events ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cohort ,medicine ,Original Article ,Lung volumes ,Esophagus ,Lung cancer ,business - Abstract
Background: Few studies to date have assessed the incidence of radiation pneumonitis (RP) in lung cancer patients who have been treated with volumetric modulated arc therapy (VMAT). This study is aimed at reporting the RP incidence rate and the risk factors associated with a symptomatic RP in patients with lung cancer treated with VMAT. Methods: A total of 77 consecutive lung cancer patients treated with VMAT from 2013 through 2015 were reviewed. RP severity was graded according to the Common Terminology Criteria for Adverse Events (CTCEA) v.4. Univariate and multivariate analyses were performed to identify the significant factors associated with RP. Results: VMAT allowed us to achieve most planning objectives on the target volumes and organs at risk, for PTV V 95% =96.8%±3.1%, for lung V 5 =41.3%±8.7%, V 10 =30.0%±7.1%, V 20 =20.9%±5.7%, for heart V 5 =43.2%±29.9%, for esophagus V 60 =8.1%±12.9%. The maximum dose of spinal cord was 34.4±9.5 Gy. The overall incidence of symptomatic RP (grade ≥2 by CTCAE) was 28.6% in the entire cohort, and the rate of grade ≥3 RP was 11.7%. Based on the multivariate analysis, factors predictive of symptomatic RP included lung volume receiving ≥10 Gy (V 10 ) (P=0.019) and C-reactive protein changing level (P=0.013). Conclusions: Our data showed that the incidence rate of RP was acceptable in lung cancer patients treated with VMAT. Additionally, we found that V10 might be an important factor for predicting the development of RP when VMAT was used; but this observation needs to be validated in future studies.
- Published
- 2018
41. Concentrations, distribution and risk of polycyclic aromatic hydrocarbons in sediments from seven major river basins in China over the past 20 years
- Author
-
Minna Zhang, Hongmin Yin, Zhenwu Tang, and Tong Meng
- Subjects
Pollution ,China ,Geologic Sediments ,Environmental Engineering ,media_common.quotation_subject ,0208 environmental biotechnology ,Drainage basin ,Distribution (economics) ,02 engineering and technology ,010501 environmental sciences ,Management, Monitoring, Policy and Law ,01 natural sciences ,Aquatic organisms ,Rivers ,Coal ,Polycyclic Aromatic Hydrocarbons ,Waste Management and Disposal ,0105 earth and related environmental sciences ,media_common ,geography ,geography.geographical_feature_category ,business.industry ,Fossil fuel ,Sediment ,General Medicine ,020801 environmental engineering ,Environmental chemistry ,Environmental science ,business ,Water Pollutants, Chemical ,Environmental Monitoring - Abstract
Polycyclic aromatic hydrocarbons (PAHs) in river sediments in China have been extensively investigated. However, most previous studies only reported information about specific locations. As a result, the distribution and changes of these chemicals in sediments nationwide remain unknown. Based on published data during 1997–2020, we conducted a systematic meta-analysis to understand the concentration, risk and the spatiotemporal variation of PAHs in river sediments from the seven major river systems in China. The report provides a national picture of PAHs in river sediments of China. Among the seven river systems, higher concentrations of sediment PAHs are found in the basins of Liaohe River and Haihe River. In the study sediments, high-molecular-mass (4–6-ring) PAHs were predominated, reflecting the widespread combustion of coal and fossil fuels across China. In addition, PAH source assessment also suggests that raw coal and crude oil are important contributors to PAH concentrations in the rivers in northeastern China. Over the past 20 years, there is no downward trend in the concentrations of Σ16PAHs in sediments in the seven river basins; but the contribution of high-temperature combustion to the pollution has declined. In addition, our calculated risks from sediment PAHs seem to decline between 1997–2006 and 2007–2017 periods, although the differences were not statistically significant (p > 0.05). Of note, the data collection and the risk assessment methods used in this preliminary survey may result in some uncertainty. Our results suggest that the PAHs in river sediments in China still need to be paid attention to due to the complexity of their sources and harms to aquatic organisms.
- Published
- 2020
42. Global distribution and trends of polybrominated diphenyl ethers in human blood and breast milk: A quantitative meta-analysis of studies published in the period 2000-2019
- Author
-
Jiali Cheng, Hongmin Yin, Zhenwu Tang, Minna Zhang, and Tong Meng
- Subjects
endocrine system ,Environmental Engineering ,Asia ,0208 environmental biotechnology ,Population ,02 engineering and technology ,010501 environmental sciences ,Management, Monitoring, Policy and Law ,Breast milk ,Biology ,01 natural sciences ,Polybrominated diphenyl ethers ,Environmental health ,Halogenated Diphenyl Ethers ,Humans ,education ,Waste Management and Disposal ,reproductive and urinary physiology ,0105 earth and related environmental sciences ,Flame Retardants ,education.field_of_study ,Human blood ,Milk, Human ,General Medicine ,humanities ,020801 environmental engineering ,Europe ,Global distribution ,Meta-analysis ,Brominated flame retardant ,North american population ,North America ,Female ,Environmental Monitoring - Abstract
Polybrominated diphenyl ethers (PBDEs) are a class of flame-retardants that are found throughout the human body. However, global trends and diversity of the concentrations in human body and the potential risks remain largely unresolved. Based on published data during 2000-2019, we conducted a systematic meta-analysis to understand the burden and risks of PBDEs in humans and their spatiotemporal variations. The report provides a global picture of PBDE concentrations in human blood and breast milk. We found the levels of body PBDE burden in the North American population were higher than those from Asia and Europe. However, high concentrations of blood PBDEs in occupational population from Asia were observed, largely because of poorly controlled e-waste recycling operations. Penta- and deca-BDE were the main contributors in North America and Asia, respectively, reflecting the difference in the production and use of these chemicals. On a global scale, no substantial decreases in the concentrations of PBDEs in the blood and breast milk were observed, although most of the chemicals have been phased out. The results suggested that humans will be exposed to PBDEs with relatively high concentrations in a certain period because of the legacy in products and the environmental media. And the potential health risks necessitate careful study in the future. Our results also remind that the uses of degradation-resistant chemicals should be attached great importance to their safety.
- Published
- 2020
43. Risk Assessment on Diabetic Peripheral Neuropathy from a Cohort of Patients in China
- Author
-
Pei Li, Qingling Chen, Xiaoyu Chen, Peiru Zhou, Jiaying Li, Xueyan Liu, Minna Zhang, Jiao Du, Junlan Yan, Jiewei Huang, and Fangting Ma
- Subjects
medicine.medical_specialty ,Cerebral infarction ,business.industry ,General Medicine ,medicine.disease ,chemistry.chemical_compound ,Peripheral neuropathy ,chemistry ,Lymphangitis ,Internal medicine ,Diabetes mellitus ,Cohort ,medicine ,Glycated hemoglobin ,Risk assessment ,business ,Venous Embolism - Abstract
Human living styles and life has been troubled by diabetes for many decades that arises from 451 million patients (ages from 18-99 years) worldwide in 2017
- Published
- 2020
44. Erratum to 'Timing in combination with radiotherapy and patterns of disease progression in non-small cell lung cancer treated with EGFR-TKI' [Lung Cancer, 140 (February) (2020) 65-70]
- Author
-
Shenglin Ma, Bing Wang, Yi Tang, Ruifei Xie, Bing Xia, Minna Zhang, Kan Wu, and Xiao Xu
- Subjects
Pulmonary and Respiratory Medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Disease progression ,MEDLINE ,medicine.disease ,Radiation therapy ,Egfr tki ,Internal medicine ,medicine ,Non small cell ,Lung cancer ,business - Published
- 2020
45. Polybrominated diphenyl ethers in soils from Tianjin, North China: distribution, health risk, and temporal trends
- Author
-
Yu, Han, Jiali, Cheng, Lei, He, Minna, Zhang, Shan, Ren, Jiazheng, Sun, Xiangyang, Xing, and Zhenwu, Tang
- Subjects
China ,Halogenated Diphenyl Ethers ,Humans ,Soil Pollutants ,Risk Assessment ,Gas Chromatography-Mass Spectrometry ,Environmental Monitoring - Abstract
Available information is still insufficient for a comprehensive understanding of the global distribution of polybrominated diphenyl ethers (PBDEs) in the environment. In particular, little is known about the changing trend of their distribution in urban soils. We conducted a survey of 21 PBDEs in urban soils from Tianjin, China. The chemicals were widely present in the area and summed concentrations ranged from 0.65 to 108 ng/g in soil, indicating low to moderate levels of pollution relative to other areas. BDE-209 was the predominant congener, contributing 88.9% of the concentrations of total soil PBDEs. Source assessment indicated that soil PBDEs in the area were mainly derived from the release of commercial deca-BDE from local industrial production processes and consumer products. We found that the soil concentrations of PBDEs appear to have declined in recent years, compared with other previous reports in this region. However, more studies are needed on this possible change trend of PBDE pollution, especially its impact on human health, although their calculated non-carcinogenic health risks in this study were low.
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- 2020
46. Heteropoly Acid Supported on Cu-Doped Three-Dimensionally Ordered Macroporous SiO2 as Efficient Catalyst for the Selective Oxidation of Methacrolein
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Minna Zhang, Tingting Wang, Xinxin Ma, Zhaoshun Zhang, Wancheng Zhu, and Heng Zhang
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010405 organic chemistry ,Doping ,Methacrolein ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Colloid ,chemistry.chemical_compound ,Methacrylic acid ,chemistry ,Specific surface area ,Selectivity ,Organometallic chemistry ,Nuclear chemistry - Abstract
Cu-doped three-dimensionally ordered macroporous (3DOM) SiO2 was prepared by a colloidal templating method and used as the support of heteropoly acid for the selective oxidation of methacrolein (MAL) to methacrylic acid (MAA). The doping effects of Cu on the structures, physico-chemical properties and catalytic performances of the catalysts were investigated. Results showed that Cu was well distributed in the SiO2 framework with the mole ratio of Cu/Si = 5%, and the specific surface area was much higher than that of the pure 3DOM SiO2. After supported with H4PMo11VO40 (HPVA), the specific surface areas of the as-synthesized catalysts significantly decreased, from 239 to 64 m2 g−1 for HPVA/3DOM (5%Cu)–SiO2 and from 141 to 32 m2 g−1 for HPVA/3DOM SiO2, respectively, because of the blockage of the micropores. The supported HPVA retained Keggin-type primary structure and its reducibility was obviously improved due to the existence of Cu in the supports, which thereby resulted in the great enhancement of the catalytic property. The conversion of MAL and the selectivity to MAA were respectively 36 and 47% on HPVA/3DOM SiO2. Comparatively, the conversion of MAL reached 63% with 82% MAA selectivity on HPVA/3DOM (5%Cu)–SiO2.
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- 2018
47. Grassland degradation with saline-alkaline reduces more soil inorganic carbon than soil organic carbon storage
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Qing Chang, Tongtong Xu, Shiwen Ding, Ying Wang, Minna Zhang, Xuan Zhao, Ling Wang, Bai Liu, and Jianyong Wang
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Topsoil ,Ecology ,Soil organic carbon ,Grassland degradation ,food and beverages ,General Decision Sciences ,chemistry.chemical_element ,Degraded grasslands ,Profile distributions ,Soil carbon ,complex mixtures ,Carbon cycle ,Carbon stocks ,stomatognathic system ,Total inorganic carbon ,chemistry ,Soil inorganic carbon ,Environmental chemistry ,Soil pH ,Environmental science ,Soil horizon ,Soil salinization ,Carbon ,QH540-549.5 ,Ecology, Evolution, Behavior and Systematics - Abstract
Grassland is an important part of terrestrial ecosystems and contain substantial amounts of soil carbon. However, 90% of grasslands suffer from degradation in northern China, where soil inorganic carbon (SIC) is a major reservoir. Previous studies have focused primarily on soil organic carbon (SOC) stock, while the effects of grassland degradation in SIC stock remains largely unexplored. Therefore, accurate assessments of both SOC and SIC stocks and their profile distributions are necessary to fully understand the role of grassland degradation in China’s carbon budget. Here, we conducted an experiment to estimate the stocks, profile distributions, and environmental controls of both SOC and SIC in patchy saline-alkaline grasslands under three degraded degrees (non-degraded patches, ND; moderately degraded patches, MD, and heavily degraded patches, HD). Our results showed that grassland degradation destroys not only SOC but also SIC stocks in saline-alkaline grasslands. SIC is the main component of soil carbon in saline-alkaline grasslands, and their distributions changed dramatically. Compared with ND, SIC losses caused by degradation accounted for 84% and 86% of total carbon loss under MD and HD patches, respectively. SIC loss primarily occurred at the intermediate soil layers (30–70 cm), while the loss of SOC was mainly in the topsoil (0–40 cm). Moreover, the distributions of SIC from 20 to 60 cm were closely related to soil pH, while it is mainly regulated by EC from 60 to 100 cm. In addition, soil pH, EC, and above-ground biomass were important variables driving the profile distributions of SOC in the upper soil. Our work provides evidence that grassland degradation mainly damages the SIC stocks. Our findings, therefore, highlight the non-negligible role of SIC dynamics in the carbon budget of degraded grassland ecosystems and the need to consider these dynamics in terrestrial carbon cycle research.
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- 2021
48. Optimized extraction of astaxanthin from shrimp shells treated by biological enzyme and its separation and purification using macroporous resin
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Minna Zhang, Dong Pei, Yuanmeng Lv, Wenjing Wang, Mei Lv, Lu Weihang, Litao Wang, Jinxia Hu, Wenjing Lv, and Ruifang Ding
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Protease ,Chromatography ,Chemistry ,Hydrolysis ,medicine.medical_treatment ,Extraction (chemistry) ,General Medicine ,Xanthophylls ,Raw material ,Analytical Chemistry ,Shrimp ,Resins, Synthetic ,chemistry.chemical_compound ,Adsorption ,Astaxanthin ,Yield (chemistry) ,Enzymatic hydrolysis ,medicine ,Resins, Plant ,Food Science - Abstract
The best enzymatic protease treatment of shrimp shells was identified by comparing the enzymatic hydrolysis effects of many different types of biological enzymes using fresh Arctic sweet shrimp as raw materials. The optimal enzymolysis conditions were determined using neutral protease as the best enzymatic protease. Among multiple macroporous adsorption resins, XDA-8 macroporous adsorption resin was preferable due to its static adsorption rate and desorption rate. The yield of astaxanthin (134.20 μg/g) after treatment with neutral protease was 3.7 times higher than that of the control group (36.03 μg/g). The yield of astaxanthin was obviously improved after enzymolysis of the shrimp shells. The purity of the astaxanthin was up to 87.34%, approximately 6508 times higher than that of the raw material. The production cost of astaxanthin would be greatly reduced by use of XDA-8 resin to obtain high-purity astaxanthin. This technique offers a high value-added utilization of shrimp shells.
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- 2021
49. Prevalence and related factors of peripheral arterial disease in diabetes mellitus inpatients: a cross-sectional study in China.
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Minna Zhang, Junlan Yan, Jiewei Huang, Kaiming Ye, Peiru Zhou, and Xueyan Liu
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- 2022
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50. The effect and safety of anlotinib combined with irinotecan or docetaxel in small-cell lung cancer (SCLC) relapsed within six months: A single-arm phase I study
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Minna Zhang, Jian Ye, Shenglin Ma, Hong Jiang, Jiaoli Wang, Bing Xia, and Xueqin Chen
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Oncology ,Cancer Research ,medicine.medical_specialty ,Chemotherapy ,Standard of care ,business.industry ,medicine.medical_treatment ,Phase i study ,Irinotecan ,Docetaxel ,Internal medicine ,medicine ,Non small cell ,business ,neoplasms ,medicine.drug - Abstract
e20583 Background: Current standard of care for SCLC relapsed within six months after first-line treatment was mainly chemotherapy alone, such as irinotecan or docetaxel, of which the clinical benefit is unsatisfactory. Anlotinib, a novel oral multi-target tyrosine kinase inhibitor primarily targeting VEGFR2/3, FGFR1-4, PDGFRα/β and c-Kit, significantly improved progression-free survival (PFS) and overall survival (OS) for SCLC in third-line setting and beyond treatment (ALTER1202 trial). Here, we conducted a single-arm phase II trial to evaluate the efficacy and safety of anlotinib combined with irinotecan or docetaxel in SCLC relapsed within six months after first-line treatment. Methods: Eligible patients with cytologically or histologically confirmed SCLC, aged 18-75 years, ECOG PS 0-1, relapsed within six months after first-line platinum-based treatment, received anlotinib (12mg, QD, from day 1 to 14 of a 21-day cycle) combined with irinotecan (65mg/m2, day1,8, q3w, up to 4 cycles) or docetaxel (60mg/m2, q3w, up to 4 cycles) until disease progression or intolerable toxicity. The primary endpoint was the objective response rate (ORR). Secondary endpoints included PFS, the disease control rate (DCR), OS and safety. Results: Between March 2020 and February 2021, 21 patients with a median age of 61.7 years, male (76.2%), ECOG PS 1 (81.0%), brain metastasis (42.9%), liver metastasis (38.1%), were enrolled in this trial. At data cut-off (February 8, 2021), 15 patients were evaluable, among which 5 patients reached partial response (PR) and 8 had stable disease (SD). The ORR was 33.3% (5/15) and the DCR was 86.7% (13/15), respectively. The median PFS was 4.0 months (95%Cl: 3.18-4.83). The most common grade 1-2 treatment-related adverse events (TRAEs) were weakness (64.7%), anorexia (41.2%), anemia (29.4%), hypertension (23.5%), leukopenia (17.6%), oral mucositis (17.6%). Grade 3 TRAEs mainly included leukopenia (11.8%), thrombocytopenia (11.8%) and anemia (5.9%). There were no grade 4 or higher toxicities. Conclusions: Anlotinib combined with irinotecan or docetaxel showed promising ORR, DCR and PFS in SCLC relapsed within six months after first-line platinum-based treatment and was well-tolerated. No unexpected toxicities were observed. Further exploration and longer follow-up are ongoing. Clinical trial information: NCT04757779.
- Published
- 2021
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