1. Cobalt-Catalyzed Defluorosilylation of Aryl Fluorides via Grignard Reagent Formation
- Author
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Eunsung Lee, Hyungdo Cho, Soobin Lim, Minjae Jang, Jongheon Jeong, Hyunseok Kim, and Seung Hwan Cho
- Subjects
010405 organic chemistry ,Aryl ,Organic Chemistry ,chemistry.chemical_element ,Grignard reagent ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,chemistry ,Physical and Theoretical Chemistry ,Cobalt - Abstract
Transition-metal-catalyzed transformations of the carbon-fluorine bond not only tackle an interesting problem of challenging bond activation but also offer new synthetic strategies where the relatively inert C-F bond is converted to versatile functional groups. Herein we report a practical cobalt-catalyzed silylation of aryl fluorides that uses a cheap electrophilic silicon source with magnesium. This method is compatible with various silicon sources and can be operated under aerobic conditions. Mechanistic studies support the in situ formation of a Grignard reagent, which is captured by the electrophilic silicon source.
- Published
- 2020