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Objective: The aim of this study was to qualitatively and semi-quantitatively analyze mast cells in periapical lesions., Materials and Methods: Biopsy specimens of 96 periapical lesions were stained with hematoxylin-eosin, histochemical Giemsa and immunohistochemical CD 117 (C kit) antibody. Mast cell count below 100 mast cells on 1000 fields of high power magnification was noted as 'negative', 101-400 as 'mild', 401-800 cells as 'moderate', and over 800 cells as 'severe'., Results: Mast cells are found in 68 (70.8%) lesions. The presence of mast cells was greater in cysts than in granulomas (P < 0.0028). There was no difference in semi-quantitative expression of CD 117 in granulomas and cysts (P > 0.05). Mast cells were placed in both: inflammatory infiltrate and in fibroblastic areas of periapical lesions, and their presence was most frequently mild to moderate., Conclusions: The findings of present study could suggest a role of mast cells in regulation of cellular immune mechanisms in periapical lesions, balancing between alterative and reparatory processes in inflamed periapical tissue.

A case of focal cemento-osseous dysplasia of the maxilla in a 19-year-old man is reported. Clinically, the lesion resembled periapical pathosis of odontogenic origin. The clinical and histopathologic features of cemento-osseous dysplasia are reviewed.

A case of periosteal osteosarcoma of the mandibular premolar region in a 20-year-old woman is described. The tumor was excised, and 5 years later the patient shows no evidence of disease. This is probably the second documented case of periosteal osteosarcoma of the mandible reported.

Liposarcomas of the oral tissues are rare. There have been 28 previously reported in the literature. A clinicopathologic study of 4 patients with liposarcoma involving the oral tissues is presented--one in the tongue, one in the palate, and two in the submandibular space. Two of the tumors were myxoid, one was of well-differentiated type and one was of pleomorphic type. Three of the lesions were diagnosed clinically as benign. The most important lesson to be learned from the histopathology is the positive identification of atypical lipoblasts. Follow-up data indicate that prognosis generally corresponds to the tumor type. The patients with myxoid and well-differentiated liposarcoma remain alive and with no evidence of disease. The patient who died of tumor had a pleomorphic liposarcoma. Treatment of these lesions should consist of wide surgical excision and consideration of adjunctive or palliative radiotherapy.

The case of a 37-year-old woman with primary acinic cell carcinoma arising in an intraparotid lymph node is presented. The patient is free of disease 20 months after superficial parotidectomy. This is probably the first histologically documented case of acinic cell carcinoma arising from intranodal salivary gland tissue. Awareness of possible malignant alteration of ectopic salivary gland tissue in lymph nodes is essential.

A 61-year-old man with a malignant mixed tumor of the parotid gland with metastasis to two lymph nodes of the digastric triangle is presented. This represents the first case of carcinoma ex-pleomorphic adenoma in which the metastases simultaneously contain elements that have both benign- and malignant-appearing histologic patterns.

A case of well-differentiated liposarcoma with floret-like multinucleated giant cells in a 59-year-old woman who presented with supraclavicular mass is described. On the biopsy section, the mass had an appearance consistent with a pleomorphic lipoma. Multiple microscopic sections revealed the pathognomic features of a well-differentiated liposarcoma.

50 cases of squamous cell carcinoma of the lower lip were analyzed histologically. Surgical specimens were examined for presence tumor-infiltrating leukocytes and pattern of stromal invasion. The estimation of the characteristics of local immune reaction was performed at the interface of the tumor and underlying tissues at the site of deepest penetration. As a result, there was a significant inverse correlation between degree of tumor-infiltrating leukocytes and pattern of invasion. Marked of tumor-infiltrating leukocytes is a manifestation of efficiently host immune response to the tumor.

A case of schwannoma in the maxilla associated with the nasopalatine nerve of a 9-year-old boy is reported. The diagnosis is supported by an immunohistochemical demonstration of S-100 protein within the tumor cells. The patient is free of disease 6 years after tumor removal.

A 40-year-old woman with a hibernoma, of unusual location in the submental space is described. The patient presented with a submental space mass, without other associated symptoms. There was no recurrence after a 4 year follow-up.

Twelve cases of verrucous carcinoma of the orofacial region were reviewed for their clinical and pathological characteristics. Verrucous carcinoma made 3.5% of all primary epidermoid carcinoma observed during the period of investigation. The tumour occurred chiefly in older patients (from 25 to 81 years, mean age 57.5) and more often in males than in females (9 males: 3 females). The most common site of occurrence was the vermilion surface of the lower lip (seven cases). Macroscopic appearance of lesions was reported as exophytic, warty, and white. Microscopically, the thickened epithelium was well differentiated and stratification was preserved. Rete pegs of carcinoma were broad and blunt; they also appeared to "puch" into underlying tissues. Basement membrane appeared to be intact. Cells of tumours were displayed, and histologic features of the spectrum were generally associated with viral modification. The prognosis in verrucous carcinoma is very good, because of the absence of metastases. Radiotherapy should not be used, since not only local recurrence is common, but also anaplastic changes may occur with corresponding aggressive behaviour and metastasis.

Primary intraosseous carcinoma (P1OC) of the jaws is rare. They either arise de novo or as a consequence of malignant transformation of a benign cyst or tumor. A 56-year-old patient with a P1OC of the mandible arising from an odontogenic keratocyst is described.

Twenty surgically treated patients (aged 14-67) were subject of analysis aiming to found localisation, intensity and cellular structure of gingival inflammatory infiltrate. Results of our research showed following characteristics of inflammatory infiltrate: location--30% superficial, 85% deep (focal) and 30% diffused infiltrate; intensity--15% weak, 40% moderate and 45% strong infiltrate; structure--60% mainly plasmocits, 20% plasmocitis and 20% mixed inflammatory infiltrate. In sulcular epithelium were very often found large amounts of granulocits and lymphocits. It can be concluded that periodotal type of gingival inflammation had local immunologic reaction. This process was mainly located in deep parts of gingival tissue and was also predominantly alterative.