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2. Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

Author

Sheth, Anagha Inguva., primary, Althoff, Mark J., additional, Tolison, Hunter, additional, Engel, Krysta, additional, Amaya, Maria L., additional, Krug, Anna E., additional, Young, Tracy N., additional, Minhajuddin, Mohammad, additional, Pei, Shanshan, additional, Patel, Sweta B., additional, Winters, Amanda, additional, Miller, Regan, additional, Shelton, Ian T., additional, St-Germain, Jonathan, additional, Ling, Tianyi, additional, Jones, Courtney L., additional, Raught, Brian, additional, Gillen, Austin E., additional, Ransom, Monica, additional, Staggs, Sarah, additional, Smith, Clayton A., additional, Pollyea, Daniel A., additional, Stevens, Brett M., additional, and Jordan, Craig T., additional

Published
2024
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4. AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

Author

Pei, Shanshan, Minhajuddin, Mohammad, Adane, Biniam, Khan, Nabilah, Stevens, Brett M, Mack, Stephen C, Lai, Sisi, Rich, Jeremy N, Inguva, Anagha, Shannon, Kevin M, Kim, Hyunmin, Tan, Aik-Choon, Myers, Jason R, Ashton, John M, Neff, Tobias, Pollyea, Daniel A, Smith, Clayton A, and Jordan, Craig T

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cancer, Rare Diseases, Stem Cell Research - Nonembryonic - Human, Stem Cell Research, Hematology, Stem Cell Research - Nonembryonic - Non-Human, Aetiology, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, AMP-Activated Protein Kinases, Animals, Cell Self Renewal, Cells, Cultured, Female, Humans, Leukemia, Myeloid, Acute, Membrane Proteins, Mice, Mice, Inbred NOD, Mice, Transgenic, Mitochondrial Proteins, Mitophagy, Neoplastic Stem Cells, Protein Kinase Inhibitors, Signal Transduction, AMPK, FIS1, GSK3, acute myeloid leukemia, differentiation, leukemia stem cells, mitochondrial dynamics, mitophagy, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Leukemia stem cells (LSCs) are thought to drive the genesis of acute myeloid leukemia (AML) as well as relapse following chemotherapy. Because of their unique biology, developing effective methods to eradicate LSCs has been a significant challenge. In the present study, we demonstrate that intrinsic overexpression of the mitochondrial dynamics regulator FIS1 mediates mitophagy activity that is essential for primitive AML cells. Depletion of FIS1 attenuates mitophagy and leads to inactivation of GSK3, myeloid differentiation, cell cycle arrest, and a profound loss of LSC self-renewal potential. Further, we report that the central metabolic stress regulator AMPK is also intrinsically activated in LSC populations and is upstream of FIS1. Inhibition of AMPK signaling recapitulates the biological effect of FIS1 loss. These data suggest a model in which LSCs co-opt AMPK/FIS1-mediated mitophagy as a means to maintain stem cell properties that may be otherwise compromised by the stresses induced by oncogenic transformation.

Published
2018

6. Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

Author

Sheth, Anagha Inguva, primary, Engel, Krysta, additional, Tolison, Hunter, additional, Althoff, Mark J, additional, Amaya, Maria L., additional, Krug, Anna, additional, Young, Tracy, additional, Pei, Shanshan, additional, Patel, Sweta B., additional, Minhajuddin, Mohammad, additional, Winters, Amanda, additional, Miller, Regan, additional, Shelton, Ian, additional, St-Germain, Jonathan, additional, Ling, Tianyi, additional, Jones, Courtney, additional, Raught, Brian, additional, Gillen, Austin, additional, Ransom, Monica, additional, Staggs, Sarah, additional, Smith, Clayton A., additional, Pollyea, Daniel A., additional, Stevens, Brett M., additional, and Jordan, Craig T., additional

Published
2023
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7. Supplementary Table 6 from A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy

Author

Pei, Shanshan, primary, Shelton, Ian T., primary, Gillen, Austin E., primary, Stevens, Brett M., primary, Gasparetto, Maura, primary, Wang, Yanan, primary, Liu, Lina, primary, Liu, Jun, primary, Brunetti, Tonya M., primary, Engel, Krysta, primary, Staggs, Sarah, primary, Showers, William, primary, Sheth, Anagha Inguva, primary, Amaya, Maria L., primary, Minhajuddin, Mohammad, primary, Winters, Amanda, primary, Patel, Sweta B., primary, Tolison, Hunter, primary, Krug, Anna E., primary, Young, Tracy N., primary, Schowinsky, Jeffrey, primary, McMahon, Christine M., primary, Smith, Clayton A., primary, Pollyea, Daniel A., primary, and Jordan, Craig T., primary

Published
2023
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8. Supplementary Table 2 from A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy

Author

Pei, Shanshan, primary, Shelton, Ian T., primary, Gillen, Austin E., primary, Stevens, Brett M., primary, Gasparetto, Maura, primary, Wang, Yanan, primary, Liu, Lina, primary, Liu, Jun, primary, Brunetti, Tonya M., primary, Engel, Krysta, primary, Staggs, Sarah, primary, Showers, William, primary, Sheth, Anagha Inguva, primary, Amaya, Maria L., primary, Minhajuddin, Mohammad, primary, Winters, Amanda, primary, Patel, Sweta B., primary, Tolison, Hunter, primary, Krug, Anna E., primary, Young, Tracy N., primary, Schowinsky, Jeffrey, primary, McMahon, Christine M., primary, Smith, Clayton A., primary, Pollyea, Daniel A., primary, and Jordan, Craig T., primary

Published
2023
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9. Supplementary Table 8 from A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy

Author

Pei, Shanshan, primary, Shelton, Ian T., primary, Gillen, Austin E., primary, Stevens, Brett M., primary, Gasparetto, Maura, primary, Wang, Yanan, primary, Liu, Lina, primary, Liu, Jun, primary, Brunetti, Tonya M., primary, Engel, Krysta, primary, Staggs, Sarah, primary, Showers, William, primary, Sheth, Anagha Inguva, primary, Amaya, Maria L., primary, Minhajuddin, Mohammad, primary, Winters, Amanda, primary, Patel, Sweta B., primary, Tolison, Hunter, primary, Krug, Anna E., primary, Young, Tracy N., primary, Schowinsky, Jeffrey, primary, McMahon, Christine M., primary, Smith, Clayton A., primary, Pollyea, Daniel A., primary, and Jordan, Craig T., primary

Published
2023
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10. Supplementary Tables 3-5 from A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy

Author

Pei, Shanshan, primary, Shelton, Ian T., primary, Gillen, Austin E., primary, Stevens, Brett M., primary, Gasparetto, Maura, primary, Wang, Yanan, primary, Liu, Lina, primary, Liu, Jun, primary, Brunetti, Tonya M., primary, Engel, Krysta, primary, Staggs, Sarah, primary, Showers, William, primary, Sheth, Anagha Inguva, primary, Amaya, Maria L., primary, Minhajuddin, Mohammad, primary, Winters, Amanda, primary, Patel, Sweta B., primary, Tolison, Hunter, primary, Krug, Anna E., primary, Young, Tracy N., primary, Schowinsky, Jeffrey, primary, McMahon, Christine M., primary, Smith, Clayton A., primary, Pollyea, Daniel A., primary, and Jordan, Craig T., primary

Published
2023
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11. Supplementary Table 7 from A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy

Author

Pei, Shanshan, primary, Shelton, Ian T., primary, Gillen, Austin E., primary, Stevens, Brett M., primary, Gasparetto, Maura, primary, Wang, Yanan, primary, Liu, Lina, primary, Liu, Jun, primary, Brunetti, Tonya M., primary, Engel, Krysta, primary, Staggs, Sarah, primary, Showers, William, primary, Sheth, Anagha Inguva, primary, Amaya, Maria L., primary, Minhajuddin, Mohammad, primary, Winters, Amanda, primary, Patel, Sweta B., primary, Tolison, Hunter, primary, Krug, Anna E., primary, Young, Tracy N., primary, Schowinsky, Jeffrey, primary, McMahon, Christine M., primary, Smith, Clayton A., primary, Pollyea, Daniel A., primary, and Jordan, Craig T., primary

Published
2023
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12. Supplementary Table 1 from A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy

Author

Pei, Shanshan, primary, Shelton, Ian T., primary, Gillen, Austin E., primary, Stevens, Brett M., primary, Gasparetto, Maura, primary, Wang, Yanan, primary, Liu, Lina, primary, Liu, Jun, primary, Brunetti, Tonya M., primary, Engel, Krysta, primary, Staggs, Sarah, primary, Showers, William, primary, Sheth, Anagha Inguva, primary, Amaya, Maria L., primary, Minhajuddin, Mohammad, primary, Winters, Amanda, primary, Patel, Sweta B., primary, Tolison, Hunter, primary, Krug, Anna E., primary, Young, Tracy N., primary, Schowinsky, Jeffrey, primary, McMahon, Christine M., primary, Smith, Clayton A., primary, Pollyea, Daniel A., primary, and Jordan, Craig T., primary

Published
2023
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13. Supplementary Table 9 from A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy

Author

Pei, Shanshan, primary, Shelton, Ian T., primary, Gillen, Austin E., primary, Stevens, Brett M., primary, Gasparetto, Maura, primary, Wang, Yanan, primary, Liu, Lina, primary, Liu, Jun, primary, Brunetti, Tonya M., primary, Engel, Krysta, primary, Staggs, Sarah, primary, Showers, William, primary, Sheth, Anagha Inguva, primary, Amaya, Maria L., primary, Minhajuddin, Mohammad, primary, Winters, Amanda, primary, Patel, Sweta B., primary, Tolison, Hunter, primary, Krug, Anna E., primary, Young, Tracy N., primary, Schowinsky, Jeffrey, primary, McMahon, Christine M., primary, Smith, Clayton A., primary, Pollyea, Daniel A., primary, and Jordan, Craig T., primary

Published
2023
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14. Supplementary Figures S1-S7 from A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy

Author

Pei, Shanshan, primary, Shelton, Ian T., primary, Gillen, Austin E., primary, Stevens, Brett M., primary, Gasparetto, Maura, primary, Wang, Yanan, primary, Liu, Lina, primary, Liu, Jun, primary, Brunetti, Tonya M., primary, Engel, Krysta, primary, Staggs, Sarah, primary, Showers, William, primary, Sheth, Anagha Inguva, primary, Amaya, Maria L., primary, Minhajuddin, Mohammad, primary, Winters, Amanda, primary, Patel, Sweta B., primary, Tolison, Hunter, primary, Krug, Anna E., primary, Young, Tracy N., primary, Schowinsky, Jeffrey, primary, McMahon, Christine M., primary, Smith, Clayton A., primary, Pollyea, Daniel A., primary, and Jordan, Craig T., primary

Published
2023
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15. Data from A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy

Author

Pei, Shanshan, primary, Shelton, Ian T., primary, Gillen, Austin E., primary, Stevens, Brett M., primary, Gasparetto, Maura, primary, Wang, Yanan, primary, Liu, Lina, primary, Liu, Jun, primary, Brunetti, Tonya M., primary, Engel, Krysta, primary, Staggs, Sarah, primary, Showers, William, primary, Sheth, Anagha Inguva, primary, Amaya, Maria L., primary, Minhajuddin, Mohammad, primary, Winters, Amanda, primary, Patel, Sweta B., primary, Tolison, Hunter, primary, Krug, Anna E., primary, Young, Tracy N., primary, Schowinsky, Jeffrey, primary, McMahon, Christine M., primary, Smith, Clayton A., primary, Pollyea, Daniel A., primary, and Jordan, Craig T., primary

Published
2023
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16. Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

Author

Pollyea, Daniel A., Stevens, Brett M., Jones, Courtney L., Winters, Amanda, Pei, Shanshan, Minhajuddin, Mohammad, D’Alessandro, Angelo, Culp-Hill, Rachel, Riemondy, Kent A., Gillen, Austin E., Hesselberth, Jay R., Abbott, Diana, Schatz, Derek, Gutman, Jonathan A., Purev, Enkhtsetseg, Smith, Clayton, and Jordan, Craig T.

Published
2018
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17. A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy

Author

Pei, Shanshan, primary, Shelton, Ian T., additional, Gillen, Austin E., additional, Stevens, Brett M., additional, Gasparetto, Maura, additional, Wang, Yanan, additional, Liu, Lina, additional, Liu, Jun, additional, Brunetti, Tonya M., additional, Engel, Krysta, additional, Staggs, Sarah, additional, Showers, William, additional, Sheth, Anagha Inguva, additional, Amaya, Maria L., additional, Minhajuddin, Mohammad, additional, Winters, Amanda, additional, Patel, Sweta B., additional, Tolison, Hunter, additional, Krug, Anna E., additional, Young, Tracy N., additional, Schowinsky, Jeffrey, additional, McMahon, Christine M., additional, Smith, Clayton A., additional, Pollyea, Daniel A., additional, and Jordan, Craig T., additional

Published
2023
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18. In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia

Author

Sahasrabudhe, Deepak M., primary, Liesveld, Jane L., additional, Minhajuddin, Mohammad, additional, Singh, Niloy A., additional, Nath, Subhangi, additional, Kumar, Vishuwes M., additional, Balys, Marlene, additional, Evans, Andrew G., additional, Azadniv, Mitra, additional, Hansen, Jeanne N., additional, Becker, Michael W., additional, Sharon, Ashoke, additional, Thomas, V Kaye, additional, Moore, Richard G., additional, Khera, Manoj K., additional, Jordan, Craig T., additional, and Singh, Rakesh K., additional

Published
2023
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19. Higher-dose venetoclax with measurable residual disease-guided azacitidine discontinuation in newly diagnosed acute myeloid leukemia

Author

Gutman, Jonathan A., primary, Winters, Amanda, additional, Kent, Andrew, additional, Amaya, Maria, additional, McMahon, Christine, additional, Smith, Clayton, additional, Jordan, Craig T., additional, Stevens, Brett, additional, Minhajuddin, Mohammad, additional, Pei, Shanshan, additional, Schowinsky, Jeffrey, additional, Tobin, Jennifer, additional, O’Brien, Kelly, additional, Falco, Angela, additional, Taylor, Elizabeth, additional, Brecl, Constance, additional, Zhou, Katie, additional, Ho, Phuong, additional, Sohalski, Connor, additional, Dell-Martin, Jessica, additional, Ondracek, Olivia, additional, Abbott, Diana, additional, and Pollyea, Daniel A., additional

Published
2023
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20. Supplementary Figures S1-S5 from Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia

Author

Pei, Shanshan, primary, Pollyea, Daniel A., primary, Gustafson, Annika, primary, Stevens, Brett M., primary, Minhajuddin, Mohammad, primary, Fu, Rui, primary, Riemondy, Kent A., primary, Gillen, Austin E., primary, Sheridan, Ryan M., primary, Kim, Jihye, primary, Costello, James C., primary, Amaya, Maria L., primary, Inguva, Anagha, primary, Winters, Amanda, primary, Ye, Haobin, primary, Krug, Anna, primary, Jones, Courtney L., primary, Adane, Biniam, primary, Khan, Nabilah, primary, Ponder, Jessica, primary, Schowinsky, Jeffrey, primary, Abbott, Diana, primary, Hammes, Andrew, primary, Myers, Jason R., primary, Ashton, John M., primary, Nemkov, Travis, primary, D'Alessandro, Angelo, primary, Gutman, Jonathan A., primary, Ramsey, Haley E., primary, Savona, Michael R., primary, Smith, Clayton A., primary, and Jordan, Craig T., primary

Published
2023
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21. Data from The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG

Author

Ye, Haobin, primary, Minhajuddin, Mohammad, primary, Krug, Anna, primary, Pei, Shanshan, primary, Chou, Chih-Hsing, primary, Culp-Hill, Rachel, primary, Ponder, Jessica, primary, De Bloois, Erik, primary, Schniedewind, Björn, primary, Amaya, Maria L., primary, Inguva, Anagha, primary, Stevens, Brett M., primary, Pollyea, Daniel A., primary, Christians, Uwe, primary, Grimes, H. Leighton, primary, D'Alessandro, Angelo, primary, and Jordan, Craig T., primary

Published
2023
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22. Supplementary Tables S1-S6 from Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia

Author

Pei, Shanshan, primary, Pollyea, Daniel A., primary, Gustafson, Annika, primary, Stevens, Brett M., primary, Minhajuddin, Mohammad, primary, Fu, Rui, primary, Riemondy, Kent A., primary, Gillen, Austin E., primary, Sheridan, Ryan M., primary, Kim, Jihye, primary, Costello, James C., primary, Amaya, Maria L., primary, Inguva, Anagha, primary, Winters, Amanda, primary, Ye, Haobin, primary, Krug, Anna, primary, Jones, Courtney L., primary, Adane, Biniam, primary, Khan, Nabilah, primary, Ponder, Jessica, primary, Schowinsky, Jeffrey, primary, Abbott, Diana, primary, Hammes, Andrew, primary, Myers, Jason R., primary, Ashton, John M., primary, Nemkov, Travis, primary, D'Alessandro, Angelo, primary, Gutman, Jonathan A., primary, Ramsey, Haley E., primary, Savona, Michael R., primary, Smith, Clayton A., primary, and Jordan, Craig T., primary

Published
2023
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23. Supplementary Data from The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG

Author

Ye, Haobin, primary, Minhajuddin, Mohammad, primary, Krug, Anna, primary, Pei, Shanshan, primary, Chou, Chih-Hsing, primary, Culp-Hill, Rachel, primary, Ponder, Jessica, primary, De Bloois, Erik, primary, Schniedewind, Björn, primary, Amaya, Maria L., primary, Inguva, Anagha, primary, Stevens, Brett M., primary, Pollyea, Daniel A., primary, Christians, Uwe, primary, Grimes, H. Leighton, primary, D'Alessandro, Angelo, primary, and Jordan, Craig T., primary

Published
2023
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24. Data from Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia

Author

Pei, Shanshan, primary, Pollyea, Daniel A., primary, Gustafson, Annika, primary, Stevens, Brett M., primary, Minhajuddin, Mohammad, primary, Fu, Rui, primary, Riemondy, Kent A., primary, Gillen, Austin E., primary, Sheridan, Ryan M., primary, Kim, Jihye, primary, Costello, James C., primary, Amaya, Maria L., primary, Inguva, Anagha, primary, Winters, Amanda, primary, Ye, Haobin, primary, Krug, Anna, primary, Jones, Courtney L., primary, Adane, Biniam, primary, Khan, Nabilah, primary, Ponder, Jessica, primary, Schowinsky, Jeffrey, primary, Abbott, Diana, primary, Hammes, Andrew, primary, Myers, Jason R., primary, Ashton, John M., primary, Nemkov, Travis, primary, D'Alessandro, Angelo, primary, Gutman, Jonathan A., primary, Ramsey, Haley E., primary, Savona, Michael R., primary, Smith, Clayton A., primary, and Jordan, Craig T., primary

Published
2023
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25. A novel type of monocytic leukemia stem cell revealed by the clinical use of venetoclax-based therapy

Author

Pei, Shanshan, primary, Gillen, Austin E, additional, Shelton, Ian T, additional, Stevens, Brett M, additional, Gasparetto, Maura, additional, Engel, Krysta, additional, Staggs, Sarah, additional, Wang, Yanan, additional, Showers, William, additional, Inguva, Anagha, additional, Amaya, Maria L, additional, Minhajuddin, Mohammad, additional, Winters, Amanda, additional, Patel, Sweta B, additional, Tolison, Hunter, additional, Krug, Anna, additional, Young, Tracy N, additional, Schowinsky, Jeffrey, additional, McMahon, Christine, additional, Smith, Clayton A, additional, Pollyea, Daniel A, additional, and Jordan, Craig T, additional

Published
2022
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26. Higher-Dose Venetoclax with Measurable Residual Disease-Guided Azacitidine Discontinuation in Newly Diagnosed Patients with Acute Myeloid Leukemia: Phase 2 Hiddav Study

Author

Gutman, Jonathan A., primary, Winters, Amanda C., additional, Kent, Andrew, additional, Amaya, Maria L., additional, McMahon, Christine M., additional, Smith, Clayton, additional, Jordan, Craig T, additional, Stevens, Brett M., additional, Minhajuddin, Mohammad, additional, Pei, Shanshan, additional, Schowinsky, Jeffrey, additional, Tobin, Jennifer, additional, O'Brien, Kelly, additional, Falco, Angela, additional, Taylor, Elizabeth, additional, Brecl, Constance, additional, Ho, Phuong, additional, Sohalski, Connor, additional, Dell-Martin, Jessica, additional, Ondracek, Olivia, additional, Abbott, Diana, additional, and Pollyea, Daniel A., additional

Published
2022
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27. Intracellular Calcium Localization Mediates the Activity of Venetoclax in Targeting Acute Myeloid Leukemia Stem Cells

Author

Inguva, Anagha, primary, Engel, Krysta L., additional, Tolison, Hunter, additional, Althoff, Mark J, additional, Pei, Shanshan, additional, Amaya, Maria L., additional, Krug, Anna, additional, Minhajuddin, Mohammad, additional, Jones, Courtney L, additional, Gillen, Austin E., additional, Ransom, Monica, additional, Staggs, Sarah, additional, Pollyea, Daniel A., additional, Smith, Clayton, additional, Stevens, Brett M., additional, and Jordan, Craig T., additional

Published
2022
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28. Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2.

Author

Culp-Hill, Rachel, Stevens, Brett M., Jones, Courtney L., Pei, Shanshan, Dzieciatkowska, Monika, Minhajuddin, Mohammad, Jordan, Craig T., and D'Alessandro, Angelo

Subjects
FATTY acid desaturase, ACUTE myeloid leukemia, VENETOCLAX, STEM cells, AZACITIDINE, NAD (Coenzyme)
Abstract

Recent advances in targeting leukemic stem cells (LSCs) using venetoclax with azacitidine (ven + aza) has significantly improved outcomes for de novo acute myeloid leukemia (AML) patients. However, patients who relapse after traditional chemotherapy are often venetoclax-resistant and exhibit poor clinical outcomes. We previously described that fatty acid metabolism drives oxidative phosphorylation (OXPHOS) and acts as a mechanism of LSC survival in relapsed/refractory AML. Here, we report that chemotherapy-relapsed primary AML displays aberrant fatty acid and lipid metabolism, as well as increased fatty acid desaturation through the activity of fatty acid desaturases 1 and 2, and that fatty acid desaturases function as a mechanism of recycling NAD+ to drive relapsed LSC survival. When combined with ven + aza, the genetic and pharmacologic inhibition of fatty acid desaturation results in decreased primary AML viability in relapsed AML. This study includes the largest lipidomic profile of LSC-enriched primary AML patient cells to date and indicates that inhibition of fatty acid desaturation is a promising therapeutic target for relapsed AML. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Targeting MDS Stem Cells with Omacetaxine and Azacitidine for Newly Diagnosed High Grade Patients: Phase 1 Trial Results and Preliminary Mechanistic Studies

Author

Stevens, Brett M., primary, Winters, Amanda C., additional, Minhajuddin, Mohammad, additional, Amaya, Maria L., additional, McMahon, Christine M., additional, Gutman, Jonathan A., additional, Smith, Clayton, additional, Wang, Deng, additional, Adkins, Connor, additional, Ondracek, Olivia, additional, Jordan, Craig T., additional, and Pollyea, Daniel A., additional

Published
2021
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31. The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG

Author

Ye, Haobin, primary, Minhajuddin, Mohammad, additional, Krug, Anna, additional, Pei, Shanshan, additional, Chou, Chih-Hsing, additional, Culp-Hill, Rachel, additional, Ponder, Jessica, additional, De Bloois, Erik, additional, Schniedewind, Björn, additional, Amaya, Maria L., additional, Inguva, Anagha, additional, Stevens, Brett M., additional, Pollyea, Daniel A., additional, Christians, Uwe, additional, Grimes, H. Leighton, additional, D'Alessandro, Angelo, additional, and Jordan, Craig T., additional

Published
2021
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32. Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells

Author

Jones, Courtney L., primary, Stevens, Brett M., additional, Pollyea, Daniel A., additional, Culp-Hill, Rachel, additional, Reisz, Julie A., additional, Nemkov, Travis, additional, Gehrke, Sarah, additional, Gamboni, Fabia, additional, Krug, Anna, additional, Winters, Amanda, additional, Pei, Shanshan, additional, Gustafson, Annika, additional, Ye, Haobin, additional, Inguva, Anagha, additional, Amaya, Maria, additional, Minhajuddin, Mohammad, additional, Abbott, Diana, additional, Becker, Michael W., additional, DeGregori, James, additional, Smith, Clayton A., additional, D’Alessandro, Angelo, additional, and Jordan, Craig T., additional

Published
2020
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34. Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia

Author

Pei, Shanshan, primary, Pollyea, Daniel A., additional, Gustafson, Annika, additional, Stevens, Brett M., additional, Minhajuddin, Mohammad, additional, Fu, Rui, additional, Riemondy, Kent A., additional, Gillen, Austin E., additional, Sheridan, Ryan M., additional, Kim, Jihye, additional, Costello, James C., additional, Amaya, Maria L., additional, Inguva, Anagha, additional, Winters, Amanda, additional, Ye, Haobin, additional, Krug, Anna, additional, Jones, Courtney L., additional, Adane, Biniam, additional, Khan, Nabilah, additional, Ponder, Jessica, additional, Schowinsky, Jeffrey, additional, Abbott, Diana, additional, Hammes, Andrew, additional, Myers, Jason R., additional, Ashton, John M., additional, Nemkov, Travis, additional, D'Alessandro, Angelo, additional, Gutman, Jonathan A., additional, Ramsey, Haley E., additional, Savona, Michael R., additional, Smith, Clayton A., additional, and Jordan, Craig T., additional

Published
2020
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35. Developmental Plasticity of Acute Myeloid Leukemia Mediates Resistance to Venetoclax-Based Therapy

Author

Pei, Shanshan, primary, Pollyea, Daniel A, primary, Gustafson, Annika, primary, Minhajuddin, Mohammad, primary, Stevens, Brett M., primary, Ye, Haobin, primary, Inguva, Anagha, primary, Amaya, Maria L, primary, Krug, Anna, primary, Jones, Courtney L, primary, Adane, Biniam, primary, Winters, Amanda, primary, Khan, Nabilah, primary, Ponder, Jessica, primary, Schowinsky, Jeffrey, primary, Hammes, Andrew, primary, Abbott, Diana, primary, Myers, Jason R, primary, Ashton, John M, primary, Gutman, Jonathan A, primary, Purev, Enkhtsetseg, primary, Ramsey, Haley E., primary, Savona, Michael R., primary, Fesik, Stephen W., primary, Smith, Clayton, primary, and Jordan, Craig T, primary

Published
2019
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37. The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells

Author

Adane, Biniam, primary, Ye, Haobin, additional, Khan, Nabilah, additional, Pei, Shanshan, additional, Minhajuddin, Mohammad, additional, Stevens, Brett M., additional, Jones, Courtney L., additional, D’Alessandro, Angelo, additional, Reisz, Julie A., additional, Zaberezhnyy, Vadym, additional, Gasparetto, Maura, additional, Ho, Tzu-Chieh, additional, Kelly, Kathleen K., additional, Myers, Jason R., additional, Ashton, John M., additional, Siegenthaler, Julie, additional, Kume, Tsutomu, additional, Campbell, Eric L., additional, Pollyea, Daniel A., additional, Becker, Michael W., additional, and Jordan, Craig T., additional

Published
2019
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38. Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells

Author

Ye, Haobin, primary, Adane, Biniam, additional, Khan, Nabilah, additional, Alexeev, Erica, additional, Nusbacher, Nichole, additional, Minhajuddin, Mohammad, additional, Stevens, Brett M., additional, Winters, Amanda C., additional, Lin, Xi, additional, Ashton, John M., additional, Purev, Enkhtsetseg, additional, Xing, Lianping, additional, Pollyea, Daniel A., additional, Lozupone, Catherine A., additional, Serkova, Natalie J., additional, Colgan, Sean P., additional, and Jordan, Craig T., additional

Published
2018
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39. Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1

Author

Gasparetto, Maura, primary, Pei, Shanshan, additional, Minhajuddin, Mohammad, additional, Khan, Nabilah, additional, Pollyea, Daniel A., additional, Myers, Jason R., additional, Ashton, John M., additional, Becker, Michael W., additional, Vasiliou, Vasilis, additional, Humphries, Keith R., additional, Jordan, Craig T., additional, and Smith, Clayton A., additional

Published
2017
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43. Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells.

Author

Pei, Shanshan, primary, Minhajuddin, Mohammad, additional, D'Alessandro, Angelo, additional, Nemkov, Travis, additional, Stevens, Brett M., additional, Adane, Biniam, additional, Khan, Nabilah, additional, Hagen, Fred K., additional, Yadav, Vinod K., additional, De, Subhajyoti, additional, Ashton, John M., additional, Hansen, Kirk C., additional, Gutman, Jonathan A., additional, Pollyea, Daniel A., additional, Crooks, Peter A., additional, Smith, Clayton, additional, and Jordan, Craig T., additional

Published
2016
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44. Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

Author

Ye, Haobin, primary, Adane, Biniam, additional, Khan, Nabilah, additional, Sullivan, Timothy, additional, Minhajuddin, Mohammad, additional, Gasparetto, Maura, additional, Stevens, Brett, additional, Pei, Shanshan, additional, Balys, Marlene, additional, Ashton, John M., additional, Klemm, Dwight J., additional, Woolthuis, Carolien M., additional, Stranahan, Alec W., additional, Park, Christopher Y., additional, and Jordan, Craig T., additional

Published
2016
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50. Rotational Rheometry of Liquid Metal Systems: A Study with Al-Si Hypoeutectic Alloys

Author

Malik, Minhajuddin Mohammad, Hamed, Mohamed, Shankar, Sumanth, and Mechanical Engineering

Subjects
Condensed Matter::Soft Condensed Matter, Physics::Fluid Dynamics, Mechanical Engineering
Abstract

[blank pages: 18, 38, 54 & 70] Rheological property such as shear viscosity and flow curve for metallic liquid systems has been evaluated. Pure Al, pure Zn, Sn based solder alloy and various compositions of Al-Si hypoeutectic binary alloys were the metallic systems included in the study. The effect of 0.023 wt % Sr edition to various compositions of Al-Si composition and shear rate experience by the liquid. A rotational rheometer was developed with a high temperature environmental furnace for this study. Three types of measurement geometry were evaluated: cone and plate, Din Coaxial and Double Concentric Cylinder (DCC). The DCC geometry has been proposed as the most practical geometry for liquid metal viscosity measurement in rotational rheometer. Analytical solution to evaluate viscosity with the rotational rheometer equipped with DCC measurement has been proposed. Further, the critical maximum allowable angular velocity for reliable viscosity evaluation has also been proposed for this system. It has been concluded that contrary to popular belief, liquid metal systems are non-Newtonian and shear thinning fluids. The effect of Si on the viscosity of Al-Si hypoeutectic alloys have been quantified as a function of shear rate and melt super heat temperatures. Further, it has been concluded that Sr additional to Al-Si alloys significantly alters the viscosity and the melt at low melt super heat temperatures. Master of Applied Science (MASc)

Published
2007

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