Search

The research field of Information Retrieval (IR) has evolved significantly, expanding beyond traditional search to meet diverse user information needs. Recently, Large Language Models (LLMs) have demonstrated exceptional capabilities in text understanding, generation, and knowledge inference, opening up exciting avenues for IR research. LLMs not only facilitate generative retrieval but also offer improved solutions for user understanding, model evaluation, and user-system interactions. More importantly, the synergistic relationship among IR models, LLMs, and humans forms a new technical paradigm that is more powerful for information seeking. IR models provide real-time and relevant information, LLMs contribute internal knowledge, and humans play a central role of demanders and evaluators to the reliability of information services. Nevertheless, significant challenges exist, including computational costs, credibility concerns, domain-specific limitations, and ethical considerations. To thoroughly discuss the transformative impact of LLMs on IR research, the Chinese IR community conducted a strategic workshop in April 2023, yielding valuable insights. This paper provides a summary of the workshop’s outcomes, including the rethinking of IR’s core values, the mutual enhancement of LLMs and IR, the proposal of a novel IR technical paradigm, and open challenges.

The optimization of culture conditions is one of the main strategies to improve the embryo development competence in in vitro fertilization (IVF). Glucose is an important carbon source while also exists in the oviductal fluid in vivo, the effect of glucose in embryo development microenvironment is still unclear. Here we employed the LC-MS to detect and analyze the metabolites in the culture medium of different cleavage stages including 2-Cell, 4-Cell and 8-Cell mouse embryos, respectively. The effects of the external glucose were estimated by measuring the development rate at different glucose concentrations from 0 to 5 mmol/L, and the gene expression changes were detected to explore the potential mechanism after the addition of glucose in the media. Our results indicated the 2-Cell and 8-Cell stages had defined characteristic metabolites, while 4-Cell stage was the transition state. Global and contiguous metabolic characteristics showed the glycometabolism play a critical role at each early cleavage stages during the embryo development. The 8-Cell rates demonstrated the addition of glucose in culture media significantly improve the embryo competence, the highest rate was 87.33% using 3 mmol/L glucose in media, in contrast only 9.95% using the media without glucose. Meanwhile, the blocked embryos were mainly enriched at 2-Cell stage. Further transcriptome study found 3 mmol/L glucose in media remarkably upregulated the gene expression of lipid biosynthesis at 2-Cell stage, the increased lipid was confirmed by nile red staining. These data indicated the glucose may promote the development competence through increasing the lipid biosynthesis to overcoming the 2-Cell block. Our findings were helpful for the further optimization of IVF culture media, as well as the estimation of embryo quality using metabolites in the culture media.

Group A rotaviruses (RVAs) are the most common etiological agents of severe acute diarrhea among children under 5 years old worldwide. At present, two live-attenuated RVA vaccines, LLR (G10P[15]) and RotaTeq (G1–G4, G6 P[8], P[5]), have been introduced to mainland China. Although RVA vaccines can provide homotypic and partially heterotypic protection against several strains, it is necessary to explore the genetic and antigenic variations between circulating RVAs and vaccine strains. In this study, we sequenced viral protein VP7 and VP4 outer capsid proteins of 50 RVA strains circulating in China from 2016 to 2019. The VP7 and VP4 sequences of almost all strains showed high homology to those of previously reported human strains and vaccine strains of the same genotype. However, in the presumed antigenic epitopes of the VP7 and VP4, multiple amino acid variations were found, regardless of the G and P genotypes of these strains. Moreover, all circulating G3 RVA strains in China potentially possess an extra N-linked glycosylation site compared with the G3 strain of RotaTeq. The potential N-linked glycosylation site at residues 69–71 was found in all G9 strains in China but not in the G9 strain of the Rotavac or Rotasill vaccine. These variations in antigenic sites might result in the selection of strains that escape the RVA neutralizing-antibody pressure imposed by vaccines. Furthermore, the G4 and P[6] genotypes in this study showed high homology to those of porcine strains, indicating the transmission of G4 and P[6] genotypes from pigs to humans in China. More genetic surveillance with antigenic evaluation in prevalent RVAs is necessary for developing and implementing rotavirus vaccines in China.

Only a few relaxors can be grown into crystals, which show high piezoelectricity, but their operable temperature range is limited by the low phase transition temperature. Here, the authors develop an approach to fabricate textured relaxor ceramics with elevated phase transition temperatures.

We simulated the stress changes around a salt basin using a static salt structure model under compressive stress background to investigate the stress perturbation caused by different salt body shapes and amplitudes. We designed a two-layer salt model with three bulges and sags using finite element methods to calculate the stress perturbation around the salt. The results show that salt shape is closely related to the stress perturbation in the sediments around the salt, and the fluctuations of the bulge and sag (smooth or steep) can also affect the stress perturbation magnitude. Extrusion horizontal stress, normal stress, and out-of-plane stress on the plane would occur near the salt uplift in a compressive tectonic stress environment. In contrast, tensile horizontal stress, out-of-plane stress, and vertical stress would occur near the salt sag. In addition, smoother bulges are associated with smaller produced stress perturbations, and steeper sags are associated with a greater reduction of stress perturbation in the sediment. The stress of a salt structure in western Kelasu of the Kuqa depression was simulated and the applicability of previous conclusions regarding this structure was verified. These conclusions provide scientific basis for the prediction of stress perturbations around salt basin systems. Key words: numerical simulation, salt structure, stress perturbation, Kuqa depression, oil drilling

In order to alleviate adverse impacts of haze on high-level vision tasks, image dehazing attracts great attention from computer vision research field in recent years. Most of existing methods are grouped into physical prior based and non-physical data-driven based categories. However, image dehazing is a challenging ill-conditioned and inherently ambiguous problem. Due to random distribution and concentration of haze, color distortion and excessive brightness often happen in physical prior based methods. Defects on high-frequency details' recovery are not solved well in non-physical data-driven methods. Therefore, to overcome these obstacles, in this paper, we have proposed an effective progressive back-traced dehazing network based on multi-resolution recurrent reconstruction strategies. A kind of irregular multi-scale convolution module is proposed to extract fine-grain local structures. And a kind of multi-resolution residual fusion module is proposed to progressively reconstruct intermediate haze-free images. We have compared our method with several popular state-of-the-art methods on public RESIDE and 2018 NTIRE Dehazing datasets. The experiment results demonstrate that our method could restore satisfactory high-frequency textures and high-fidelity colors. Related source code and parameters will be distributed on Github for further study.

Although sperm preservation is a common means of personal fertility preservation, its effects on embryonic development potential need further investigation. The purpose of this study was to identify key microRNA (miRNA) in cryopreserved sperm and determine the changes of these miRNAs and their target genes during embryonic development using cryopreserved sperm. Moreover, the embryonic development potential of cryopreserved sperm was estimated in assisted reproductive technology (ART), where key miRNAs and target genes were validated in sperm and subsequent embryos. Clinical data of embryonic development from cryopreserved sperm indicated a significant decrease in fertilization rate in both in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cases, as well as a reduction in blastocyst formation rate in ICSI cases. Meanwhile there was a significant increase in blocked embryo ratio of Day1, Day2, and Day3.5 embryos when frozen-thawed mouse sperm was used, compared with fresh mouse sperm, suggesting a potential negative effect of sperm cryopreservation on embryonic development. From frozen-thawed and fresh sperm in humans and mice, respectively, 21 and 95 differentially expressed miRNAs (DEmiRs) were detected. miR-148b-3p were downregulated in both human and mouse frozen-thawed sperm and were also decreased in embryos after fertilization using cryopreserved sperm. Target genes of miR-148b-3p, Pten, was identified in mouse embryos using quantitative real-time PCR (qRT-PCR) and Western blot (WB). In addition, common characters of cryopreservation of mouse oocytes compared with sperm were also detected; downregulation of miR-148b-3p was also confirmed in cryopreserved oocytes. In summary, our study suggested that cryopreservation of sperm could change the expression of miRNAs, especially the miR-148b-3p across humans and mice, and may further affect fertilization and embryo development by increasing the expression of Pten. Moreover, downregulation of miR-148b-3p induced by cryopreservation was conserved in mouse gametes.

Finger vein recognition has drawn increasing attention as one of the most popular and promising biometrics due to its high distinguishing ability, security, and non-invasive procedure. The main idea of traditional schemes is to directly extract features from finger vein images and then compare features to find the best match. However, the features extracted from images contain much redundant data, while the features extracted from patterns are greatly influenced by image segmentation methods. To tackle these problems, this paper proposes a new finger vein recognition algorithm by generating code. The proposed method does not require an image segmentation algorithm, is simple to calculate, and has a small amount of data. Firstly, the finger vein images were divided into blocks to calculate the mean value. Then, the centrosymmetric coding was performed using the matrix generated by blocking and averaging. The obtained codewords were concatenated as the feature codewords of the image. The similarity between vein codes is measured by the ratio of minimum Hamming distance to codeword length. Extensive experiments on two public finger vein databases verify the effectiveness of the proposed method. The results indicate that our method outperforms the state-of-the-art methods and has competitive potential in performing the matching task.

Nowadays, the state-of-the-art mobile visual sensors technology makes it easy to collect a great number of clothing images. Accordingly, there is an increasing demand for a new efficient method to retrieve clothing images by using mobile visual sensors. Different from traditional keyword-based and content-based image retrieval techniques, sketch-based image retrieval provides a more intuitive and natural way for users to clarify their search need. However, this is a challenging problem due to the large discrepancy between sketches and images. To tackle this problem, we present a new sketch-based clothing image retrieval algorithm based on sketch component segmentation. The proposed strategy is to first collect a large scale of clothing sketches and images and tag with semantic component labels for training dataset, and then, we employ conditional random field model to train a classifier which is used to segment query sketch into different components. After that, several feature descriptors are fused to describe each component and capture the topological information. Finally, a dynamic component-weighting strategy is established to boost the effect of important components when measuring similarities. The approach is evaluated on a large, real-world clothing image dataset, and experimental results demonstrate the effectiveness and good performance of the proposed method.

Group A rotaviruses (RVAs) are the most common etiological agents of severe acute diarrhea among children under 5 years old worldwide. At present, two live-attenuated RVA vaccines, LLR (G10P[15]) and RotaTeq (G1–G4, G6 P[8], P [5]), have been introduced to mainland China. Although RVA vaccines can provide homotypic and partially heterotypic protection against several strains, it is necessary to explore the genetic and antigenic variations between circulating RVAs and vaccine strains. In this study, we sequenced viral protein VP7 and VP4 outer capsid proteins of 50 RVA strains circulating in China from 2016 to 2019. The VP7 and VP4 sequences of almost all strains showed high homology to those of previously reported human strains and vaccine strains of the same genotype. However, in the presumed antigenic epitopes of the VP7 and VP4, multiple amino acid variations were found, regardless of the G and P genotypes of these strains. Moreover, all circulating G3 RVA strains in China potentially possess an extra N-linked glycosylation site compared with the G3 strain of RotaTeq. The potential N-linked glycosylation site at residues 69–71 was found in all G9 strains in China but not in the G9 strain of the Rotavac or Rotasill vaccine. These variations in antigenic sites might result in the selection of strains that escape the RVA neutralizing-antibody pressure imposed by vaccines. Furthermore, the G4 and P[6] genotypes in this study showed high homology to those of porcine strains, indicating the transmission of G4 and P [6] genotypes from pigs to humans in China. More genetic surveillance with antigenic evaluation in prevalent RVAs is necessary for developing and implementing rotavirus vaccines in China. [ABSTRACT FROM AUTHOR]