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128 results on '"Mingot Castellano, Maria Eva"'

1. ADAMTS13 recovery in acute thrombotic thrombocytopenic purpura after caplacizumab therapy

Author

Abio Calvete, Mariola, Albert, Albert, Alberto López García, Alberto, Alegre, Adrian, Alkorta Eizagirre, Aitziber, Alonso Escobar, María Nieves, Alonso Madrigal, Cristina, Amunarriz, Cristina, Antelo Caamaño, María Luisa, Arbona Castaño, Cristina, Ballester Ruiz, Maria Carmen, Ballina Martín, Belén, Berberana Fernández de Murias, Margarita, Berrueco Moreno, Ruben, Bueno, Jose Luis, Calderón López, María Teresa, Chica Gullón, Esther, Cid Vidal, Joan, Contreras Barbeta, Enric, Cuéllar Pérez-Ávila, Clara, de la Rubia Comos, Javier, Del Orbe Barreto, Rafael Andres, Del Río Garma, Julio, Díaz Valdés, José R., Diaz-Ricart, Maribel, Diez Gallarreta, Zuriñe, Dueñas Hernando, Virginia, Eguia, Blanca, Escoda, Lourdes, Fernández Docampo, Marta, Fernandez Fuertes, Fernando, Fernández Muñoz, Hermogenes, Fernández Sánchez de Mora, Maria Carmen, Fernandez Zarzoso, Miguel, Fidalgo, Teresa, Flores Ballester, Elena, Fonte Feal, Cristina, Galvez, Francisco Javier, Garcia Arroba Peinado, Jose, García Candel, Faustino, Garcia Erce, Jose Antonio, García Gala, José María, Gimeno, JJ, Gómez, Delia, Gómez Seguí, Inés, Gomez Vazquez, Maria Jesus, Gonzalez, Carlos, González Fernández, Fernando Ataulfo, Gonzalez Porras, Jose Ramon, Gonzalez Rodriguez, Victoria Paz, Goterris Viciedo, Rosa, Guerra Domínguez, Luisa, Guillén García, Helga, Hernandez, Adoracion, Hernández Castellet, José Carlos, Hernandez Mohedo, Francisca, Hernandez Vazquez, Laura, Hidalgo Soto, Marta, Hong Tam, Azueg Hang, Kerguelen Fuentes, Ana Lilia, Leal Bento, Marta, Lopes, Raquel, López, Olga, López Chuliá, Francisca, Maria Jose Busto, Maria Jose, Martín Hernández, María Paz, Martinez Estefano, Elvira, Martinez Nieto, Jorge, Martinez Redondo, Consuelo, Martinez Revuelta, Eva, Medina Marrero, Laura, Mingot Castellano, María Eva, Morales Sanz, María Dolores, Moreno, Gemma, Moreno Beltrán, Mª Esperanza, Moreno Chulilla, Jose Antonio, Nistal Gil, Sara, Oliva Hernandez, Ana Yurena, Pascual, Teresa, Pascual Izquierdo, Crisina, Paumard Rodríguez, Elena, Pecos, Patricia, Peña Marcos, Francisco, Pereira Coelho, Daniela Sofia, Pérez Segura, Gloria Maria, Perez-Lopez, Olga, Prieto Pareja, Elena, Ramiro, Laia, Richart López, Luis Alberto, Rodriguez Dominguez, Maria Jesus, Rodriguez Nuñez, Antonio, Ruiz Sainz, María Elena, Saez Serrano, Isabel, Salinas Argente, Ramón, Sanchez, Maria Elena, Sanchez Anton, Piva, Sánchez Fernández, Mª Soledad, Sebastian, Elena, Simona, Gabriela, Solanich Moreno, Xabier, Soledad Casado, Soledad, Tallón, Jose David, Turcu, Violeta, Valledor Méndez, Manuel, Vidan Y Estevez, Julia, Viejo Llorente, Aurora, Bienert, Álvaro, Serrano, Alfons, Llorente, Laura, Campuzano, Verónica, Tallón, Inmaculada, Pons, Verónica, Linares, Mónica, Valles, Ana, Martínez Francés, Antonio, Freiria, Carmen, González Arias, Elena, Araujo, Enmanuel, Marco de Lucas, Fernando, López, Juan Antonio, Uribe Barrientos, Marisol, Calviño, Michael, Gómez Calafat, Montse, Marco Vera, Pascual, Fariña, Sabela, Zalba, Saioa, Monsalvo, Silvia, Escamilla, Virginia, Mingot-Castellano, María-Eva, García-Candel, Faustino, Martínez-Nieto, Jorge, García-Arroba, José, de la Rubia-Comos, Javier, Gómez-Seguí, Inés, Paciello-Coronel, María-Liz, Valcárcel-Ferreiras, David, Jiménez, Moraima, Cid, Joan, Lozano, Miquel, García-Gala, José-María, Angós-Vazquez, Sonia, Vara-Pampliega, Miriam, Guerra-Domínguez, Luisa, Ávila-Idrobo, Laura-Francisca, Oliva-Hernandez, Ana, Zalba-Marcos, Saioa, Tallón-Ruiz, Inmaculada, Ortega-Sánchez, Sandra, Goterris-Viciedo, Rosa, Moreno-Jiménez, Gemma, Domínguez-Acosta, Lourdes, Araiz-Ramírez, María, Hernández-Mateos, Luis, Flores-Ballesteros, Elena, del Río-Garma, Julio, and Pascual-Izquierdo, Cristina

Published
2024
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2. Efficacy and safety of the neonatal Fc receptor inhibitor efgartigimod in adults with primary immune thrombocytopenia (ADVANCE IV): a multicentre, randomised, placebo-controlled, phase 3 trial

Author

Fillitz, Michael, Knoebl, Paul, Meers, Stef, Amine, Ismail Mohamad, Gumulec, Jaromir, Hlusi, Antonin, Mayer, Jiri, Quittet, Philippe, Viallard, Jean-Francois, Betaneli, Magdana, Datikashvili-David, Irine, Iosava, Genadi, Makhaldiani, Levan, Rejto, Laszlo, Sharashenidze, Nino, Groepper, Stefanie, Röth, Alexander, Hamed, Aryan, Illes, Arpad, Carpenedo, Monica, Artoni, Andrea, Bocchia, Monica, Gamberi, Barbara, Borchiellini, Alessandra, Oliva, Esther Natalie, Patriarca, Andrea, Tomassetti, Simona, Miyakawa, Yoshitaka, Ando, Kiyoshi, Handa, Hiroshi, Katsutani, Shinya, Nishiwaki, Kaichi, Ito, Shoko, Ito, Tomoki, de Boer, Fransien, Jansen, A.J. Gerard, Ciepluch, Hanna, Fornagiel, Szymon, Grosicki, Sebastian, Soroka-Wojtaszko, Maria, Trelinski, Jacek, Bakirov, Bulat, Borisenkova, Elena, Volodicheva, Elena, Shatokhin, Yuri, Proydakov, Andrey, Alonso, Maria Aranzazu, Mingot-Castellano, María Eva, Sanchez-Gonzalez, Blanca, Valcarcel Ferreiras, David, Ayli, Meltem, Hacibekiroglu, Tuba, Demir, Ahmet Muzaffer, Nalçaci, Meliha, Sonmez, Mehmet, Tombak, Anil, Toprak, Selami Kocak, Turgut, Burhan, Vural, Filiz, Yagci, Munci, Altuntas, Fevzi, Turgut, Mehmet, Kaya, Emin, Romanyuk, Nataliya, McDonald, Vickie, Kazmi, Syed Rashid Saeed, Broome, Catherine, Cataland, Spero, Doshi, Ketan, Lentz, Steven R., Boxer, Michael, Rosenberg, Richard, Broome, Catherine M, Kuter, David J, Al-Samkari, Hanny, Bussel, James B, Godar, Marie, Ayguasanosa, Jaume, De Beuf, Kristof, Rodeghiero, Francesco, Michel, Marc, and Newland, Adrian

Published
2023
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4. P1605: IMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA IN OLDER PATIENTS: RESULTS FROM THE SPANISH TTP REGISTRY (REPTT)

Author

Inés Gómez Seguí, Eva Frances Aracil, Mingot-Castellano Maria Eva, M Vara Pampliega, Rosa Goterris, F García Candel, Cristina Pascual Izquierdo, Julio del Rio Garma, Luisa Guerra Dominguez, Isabel Vicuña Andrés, Jose Garcia-Arroba Peinado, Saioa Zalba Marcos, Julia Vidan Estevez, Elena Gonzalez, Veronica Campuzano Saavedra, Jose Maria Garcia Gala, S Ortega Sanchez, Jorge Martínez Nieto, Laura Pardo Gambarte, Maria Sole Rodríguez, Marta Fernandez Docampo, Laura F. Ávila Idrovo, Luis M. Hernández, Joan Cid, and Javier DE LA Rubia

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
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5. Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura

Author

Izquierdo, Cristina Pascual, Mingot-Castellano, María Eva, Fuentes, Ana E. Kerguelen, García-Arroba Peinado, José, Cid, Joan, Jimenez, Maria Moraima, Valcarcel, David, Gómez-Seguí, Inés, de la Rubia, Javier, Martin, Paz, Goterris, Rosa, Hernández, Luis, Tallón, Inmaculada, Varea, Sara, Fernández, Marta, García-Muñoz, Nadia, Vara, Míriam, Zarzoso, Miguel Fernández, García-Candel, Faustino, Paciello, María Liz, García-García, Irene, Zalba, Saioa, Campuzano, Verónica, Gala, José María, Estévez, Julia Vidán, Jiménez, Gemma Moreno, López Lorenzo, José Luis, Arias, Elena González, Freiría, Carmen, Solé, María, Ávila Idrovo, Laura Francisca, Hernández Castellet, José Carlos, Cruz, Naylen, Lavilla, Esperanza, Pérez-Montaña, Albert, Atucha, Jon Ander, Moreno Beltrán, María Esperanza, Moreno Macías, Juán Ramón, Salinas, Ramón, and del Rio-Garma, Julio

Published
2022
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6. The seasonal distribution of immune thrombotic thrombocytopenic purpura is influenced by geography: Epidemiologic findings from a multi‐center analysis of 719 disease episodes.

Author

Jacobs, Jeremy W., Stanek, Caroline G., Booth, Garrett S., Symeonidis, Argiris, Shih, Andrew W., Allen, Elizabeth S., Gavriilaki, Eleni, Grossman, Brenda J., Pavenski, Katerina, Moorehead, Amy, Peyvandi, Flora, Agosti, Pasquale, Mancini, Ilaria, Stephens, Laura D., Raval, Jay S., Mingot‐Castellano, Maria Eva, Crowe, Elizabeth P., Daou, Laetitia, Pai, Menaka, and Arnold, Donald M.

Published
2024
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7. Avatrombopag plus fostamatinib combination as treatment in patients with multirefractory immune thrombocytopenia.

Author

Mingot‐Castellano, Maria Eva, Bastida, Jose Maria, Ghanima, Waleed, Ruiz Sainz, Elena, Nuñez Vazquez, Ramiro, Pedrote Amador, Begoña, Abdel‐Kader Martín, Laila, Piquer‐Monsonis, Dolores, and Canaro, Mariana

Subjects
*IDIOPATHIC thrombocytopenic purpura, *AVATROMBOPAG, *DISEASE relapse, *DRUGS
Abstract

Summary: Immune thrombocytopenia (ITP) refractory to multiple therapies may require a combination of drugs targeting different mechanisms and targets. In this retrospective, multicentre, international study, we report the safety and effectiveness of avatrombopag and fostamatininb in combination administered to 18 patients with multirefractory ITP. Overall, the combination response was achieved in 15 patients (83.3%), with a median time from combination start to best response of 15 days (IQR: 8–35 days). After a median follow‐up of 256 days (IQR: 142.8–319), 5 patients relapsed (26.7%), all during tapering or stopping one drug. Adverse events were described in 6 of 18 patients (33%). [ABSTRACT FROM AUTHOR]

Published
2024
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8. Use of Eltrombopag to Improve Thrombocytopenia and Tranfusion Requirement in Anti-CD19 CAR-T Cell-Treated Patients.

Author

Mingot-Castellano, Maria-Eva, Reguera-Ortega, Juan Luis, Zafra Torres, Denis, Hernani, Rafael, Lopez-Godino, Oriana, Guerreiro, Manuel, Herrero, Blanca, López-Corral, Lucia, Luna, Alejandro, Gonzalez-Pinedo, Lesli, Chinea-Rodriguez, Anabelle, Africa-Martín, Ana, Bailen, Rebeca, Martinez-Cibrian, Nuria, Balsalobre, Pascual, Filaferro, Silvia, Alonso-Saladrigues, Anna, Barba, Pere, Perez-Martinez, Antonio, and Calbacho, María

Subjects
*RED blood cell transfusion, *THROMBOPOIETIN receptor agonists, *BLOOD platelet transfusion, *ERYTHROCYTES, *CELL transplantation
Abstract

Background/Objectives: Immune effector cell-associated hematotoxicity (ICAHT) is a frequent adverse event after chimeric antigen receptor (CAR)-T cell therapy. Grade ≥ 3 thrombocytopenia occurs in around one-third of patients, and many of them become platelet transfusion-dependent. Eltrombopag is a thrombopoietin receptor agonist (TPO-RA) able to accelerate megakaryopoiesis, which has been used successfully in patients with bone marrow failure and immune thrombocytopenia (ITP). Its role in managing thrombocytopenia and other cytopenias in CAR-T cell-treated patients has been scarcely addressed. Our aim was to report the safety and efficacy of this approach in patients included in the Spanish Group for Hematopoietic Transplantation and Cellular Therapy (GETH-TC) registry. Methods: This is a retrospective, multicenter, observational study. Patients who developed platelet transfusion dependence subsequently to CAR-T cells and received eltrombopag to improve platelet counts were recruited in 10 Spanish hospitals. Results: Thirty-eight patients were enrolled and followed up for a median (interquartile range [IQR]) of 175 (99, 489) days since CAR-T cell infusion. At the moment eltrombopag was indicated, 18 patients had thrombocytopenia and another severe cytopenia, while 8 patients had severe pancytopenia. After 32 (14, 38) days on eltrombopag, 29 (76.3%) patients recovered platelet transfusion independence. The number of platelet units transfused correlated with the time needed to restore platelet counts higher than 20 × 109/L (Rho = 0.639, p < 0.001). Non-responders to eltrombopag required more platelet units (58 [29, 69] vs. 12 [6, 26] in responders, p = 0.002). Nineteen out of twenty-three (82.6%) patients recovered from severe neutropenia after 22 (11, 31) days on eltrombopag. Twenty-nine out of thirty-five (82.9%) patients recovered red blood cell (RBC) transfusion independence after 29 (17, 44) days. Seven patients recovered all cell lineages while on treatment. No thromboembolic events were reported. Only two transient toxicities (cholestasis, hyperbilirubinemia) were reported during eltrombopag treatment, none of which compelled permanent drug withdrawal. Conclusions: Eltrombopag could be safely used to manage thrombocytopenia and accelerate transfusion independence in CAR-T cell-treated patients. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Evans syndrome in adults: an observational multicenter study

Author

Fattizzo, Bruno, Michel, Marc, Giannotta, Juri Alessandro, Hansen, Dennis Lund, Arguello, Maria, Sutto, Emanuele, Bianchetti, Nicola, Patriarca, Andrea, Cantoni, Silvia, Mingot-Castellano, María Eva, McDonald, Vickie, Capecchi, Marco, Zaninoni, Anna, Consonni, Dario, Vos, Josephine Mathilde, Vianelli, Nicola, Chen, Frederick, Glenthøj, Andreas, Frederiksen, Henrik, González-López, Tomás José, and Barcellini, Wilma

Published
2021
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10. Management of acquired hemophilia A: results from the Spanish registry

Author

Mingot-Castellano, María-Eva, Pardos-Gea, Josep, Haya, Saturnino, Bastida-Bermejo, José-María, Tàssies, Dolors, Marco-Rico, Ana, Núñez, Ramiro, García-Candel, Faustino, de Mora, María-Carmen Fernández-Sanchez, Soto, Inmaculada, Álvarez-Román, María-Teresa, Asenjo, Susana, Carrasco, Marina, Lluch-García, Rafael, Martín-Antorán, José-Manuel, Rodríguez-Alén, Agustín, Roselló, Elena, Torres-Miñana, Laura, Marcellini-Antonio, Shally, Moretó-Quinana, Ana, Rodríguez-García, José-Antonio, Aguinaco-Culebras, Reyes, Alonso-Escobar, Nieves, Cervero-Santiago, Carlos, Fernández-Mosteirín, Núria, Martínez-Badás, María-Paz, Pérez-Sánchez, Montserrat, Pérez-Montes, Rocío, Rodríguez-González, Ramón, Uribe-Barrientos, Marisol, Caparrós-Miranda, Isabel Socorro, Iglesias-Fernández, Miriam, Baena, Ángela, Rodríguez-López, Manuel, Sebrango-Sandia, Ana, Vázquez-Fernández, Irene, and Marco, Pascual

Published
2021
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11. Thrombotic thrombocytopenic purpura: 100 years of research on Moschcowitz syndrome

Author

Cataland, Spero R., Coppo, Paul, Scully, Marie, Lämmle, Bernhard, Alberio, Lorenzo, Antun, Ana, Ay, Cihan, Agosti, Pasquale, Azoulay, Elie, Baker, Ross, Benhamou, Ygal, Boechat, Tiago, Brinkkötter, Paul, Chaturvedi, Shruti, Crawley, James, De Cristofaro, Raimondo, Garma, Julio del Río, Dutt, Tina, De Groot, Rens, Rubia, Javier de la, Falter, Tanja, Farias, João, Friedman, Kenneth, Fujimura, Yoshihiro, Gavriilaki, Eleni, George, James N., Graça, Nuno A. G., Hassenpflug, Wolf-Achim, Izquierdo, Cristina Pascual, Joly-Laffargue, Bérangère, Kentouche, Karim, Knoebl, Paul, Kokame, Koichi, Hovinga, Johanna Kremer, Kühne, Lucas, Kyrle, Paul, Lester, Will, Mancini, Ilaria, Masias, Camila, Matsumoto, Masanori, Mazepa, Marshall, Miesbach, Wolfgang, Metjian, Ara, Mingot-Castellano, Maria-Eva, Miyata, Toshiyuki, Moake, Joel, Muia, Joshua, Patriquin, Chris, Pavenski, Katerina, Prohaszka, Zoltan, Peyvandi, Flora, Reti, Marienn, Rossmann, Heidi, Sakai, Kazuya, Sarode, Ravi, Schneppenheim, Reinhard, Schraner, Marissa, Singh, Deepak, Sinkovits, György, Stubbs, Matthew, Studt, Jan-Dirk, Sukumar, Senthil, Thomas, Mari, Tóth, Andor, Vanhoorelbeke, Karen, Veyradier, Agnes, Völker, Linus, Sophie von Krogh, Anne, Voorberg, Jan, Waage, Anders, Westwood, JP, Wood, Erica, Yagi, Hideo, and Zheng, X. Long

Abstract

[Display omitted]

Published
2024
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12. ADAMTS13 RECOVERY IN ACUTE THROMBOTIC THROMBOCYTOPENIC PURPURA AFTER CAPLACIZUMAB THERAPY. THE SPANISH REGISTRY

Author

Mingot-Castellano, Maria Eva, primary, García-Candel, Faustino, additional, Nieto, Jorge Martinez, additional, García-Arroba Peinado, José, additional, de la Rubia Comos, Javier, additional, Gomez-Segui, Ines, additional, Paciello-Coronel, María-Liz, additional, Valcarcel, David, additional, Jiménez, Moraima, additional, Cid, Joan, additional, Lozano, Miquel, additional, García-Gala, José-María, additional, Angós-Vazquez, Sonia, additional, Vara Pampliega, Miriam, additional, Guerra Dominguez, Luisa, additional, Ávila-Idrovo, Laura-Francisca, additional, Oliva Hernandez, Ana, additional, Zalba, Saioa, additional, Tallón Ruiz, Inmaculada, additional, Ortega Sánchez, Sandra, additional, Goterris, Rosa, additional, Moreno Jimenez, Maria Gemma, additional, Domínguez-Acosta, Lourdes, additional, Araiz-Ramírez, María, additional, Hernández-Mateo, Luis M, additional, Flores Ballester, Elena, additional, del Rio-Garma, Julio, additional, and Pascual Izquierdo, Cristina, additional

Published
2024
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14. Thrombotic thrombocytopenic purpura: 100 years of research on Moschcowitz syndrome

Author

Alberio, Lorenzo, Antun, Ana, Ay, Cihan, Agosti, Pasquale, Azoulay, Elie, Baker, Ross, Benhamou, Ygal, Boechat, Tiago, Brinkkötter, Paul, Chaturvedi, Shruti, Crawley, James, De Cristofaro, Raimondo, Garma, Julio del Río, Dutt, Tina, De Groot, Rens, Rubia, Javier de la, Falter, Tanja, Farias, João, Friedman, Kenneth, Fujimura, Yoshihiro, Gavriilaki, Eleni, George, James N., Graça, Nuno A. G., Hassenpflug, Wolf-Achim, Izquierdo, Cristina Pascual, Joly-Laffargue, Bérangère, Kentouche, Karim, Knoebl, Paul, Kokame, Koichi, Hovinga, Johanna Kremer, Kühne, Lucas, Kyrle, Paul, Lester, Will, Mancini, Ilaria, Masias, Camila, Matsumoto, Masanori, Mazepa, Marshall, Miesbach, Wolfgang, Metjian, Ara, Mingot-Castellano, Maria-Eva, Miyata, Toshiyuki, Moake, Joel, Muia, Joshua, Patriquin, Chris, Pavenski, Katerina, Prohaszka, Zoltan, Peyvandi, Flora, Reti, Marienn, Rossmann, Heidi, Sakai, Kazuya, Sarode, Ravi, Schneppenheim, Reinhard, Schraner, Marissa, Singh, Deepak, Sinkovits, György, Stubbs, Matthew, Studt, Jan-Dirk, Sukumar, Senthil, Thomas, Mari, Tóth, Andor, Vanhoorelbeke, Karen, Veyradier, Agnes, Völker, Linus, Sophie von Krogh, Anne, Voorberg, Jan, Waage, Anders, Westwood, JP, Wood, Erica, Yagi, Hideo, Zheng, X. Long, Cataland, Spero R., Coppo, Paul, Scully, Marie, and Lämmle, Bernhard

Published
2024
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15. Recommendations for the Clinical Approach to Primary Immune Thrombocytopenia

Author

Mingot-Castellano, Maria Eva, primary, Canaro Hirnyk, Mariana, additional, Sánchez-González, Blanca, additional, Alvarez-Roman, Maria Teresa, additional, Bárez-García, Abelardo, additional, Bernardo-Gutiérrez, Ángel, additional, Bernat-Pablo, Silvia, additional, Bolaños-Calderón, Estefanía, additional, Butta-Coll, Nora, additional, Caballero-Navarro, Gonzalo, additional, Caparrós-Miranda, Isabel Socorro, additional, Entrena Ureña, Laura, additional, Fernández-Fuertes, Luis Fernando, additional, García-Frade, Luis Javier, additional, Gómez del Castillo Solano, María del Carmen, additional, González-López, Tomás José, additional, Grande-García, Carlos, additional, Guinea de Castro, José María, additional, Jarque-Ramos, Isidro, additional, Jiménez-Bárcenas, Reyes, additional, López-Ansoar, Elsa, additional, Martínez-Carballeira, Daniel, additional, Martínez-Robles, Violeta, additional, Monteagudo-Montesinos, Emilio, additional, Páramo-Fernández, José Antonio, additional, Perera-Álvarez, María del Mar, additional, Soto-Ortega, Inmaculada, additional, Valcárcel-Ferreiras, David, additional, and Pascual-Izquierdo, Cristina, additional

Published
2023
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16. Autoimmune hemolytic anemia during pregnancy and puerperium:an international multicenter experience

Author

Fattizzo, Bruno, Bortolotti, Marta, Fantini, Norma N., Glenthøj, Andreas, Michel, Marc, Napolitano, Mariasanta, Raso, Simona, Chen, Frederick, McDonald, Vickie, Murakhovskaya, Irina, Vos, Josephine Mathilde Iris, Patriarca, Andrea, Mingot-Castellano, Maria Eva, Giordano, Giulio, Scarrone, Margherita, González-López, Tomás José, Trespidi, Laura, Prati, Daniele, Barcellini, Wilma, Fattizzo, Bruno, Bortolotti, Marta, Fantini, Norma N., Glenthøj, Andreas, Michel, Marc, Napolitano, Mariasanta, Raso, Simona, Chen, Frederick, McDonald, Vickie, Murakhovskaya, Irina, Vos, Josephine Mathilde Iris, Patriarca, Andrea, Mingot-Castellano, Maria Eva, Giordano, Giulio, Scarrone, Margherita, González-López, Tomás José, Trespidi, Laura, Prati, Daniele, and Barcellini, Wilma

Abstract

Relapsing or occurring de novo autoimmune hemolytic anemia (AIHA) during pregnancy or puerperium is a poorly described condition. Here, we report 45 pregnancies in 33 women evaluated at 12 centers from 1997 to 2022. Among the 20 women diagnosed with AIHA before pregnancy, 10 had a relapse. An additional 13 patients developed de novo AIHA during gestation/puerperium (2 patients had AIHA relapse during a second pregnancy). Among 24 hemolytic events, anemia was uniformly severe (median Hb, 6.4 g/dL; range, 3.1-8.7) and required treatment in all cases (96% steroids ± intravenous immunoglobulin, IVIG, 58% transfusions). Response was achieved in all patients and was complete in 65% of the cases. Antithrombotic prophylaxis was administered to 8 patients (33%). After delivery, rituximab was administered to 4 patients, and cyclosporine was added to 1 patient. The rate of maternal complications, including premature rupture of membranes, placental detachment, and preeclampsia, was 15%. Early miscarriages occurred in 13% of the pregnancies. Fetal adverse events (22% of cases) included respiratory distress, fetal growth restriction, preterm birth, AIHA of the newborn, and 2 perinatal deaths. In conclusion, the occurrence of AIHA does not preclude the ability to carry out a healthy pregnancy, provided close monitoring, prompt therapy, and awareness of potential maternal and fetal complications.

Published
2023

18. AUTOIMMUNE HEMOLYTIC ANEMIA DURING PREGNANCY AND PUERPERIUM: AN INTERNATIONAL MULTI-CENTER EXPERIENCE

Author

Fattizzo, Bruno, primary, Bortolotti, Marta, additional, Fantini, Norma Nadia, additional, Glenthøj, Andreas, additional, Michel, Marc, additional, Napolitano, Mariasanta, additional, Raso, Simona, additional, Chen, Frederick, additional, McDonald, Vickie, additional, Murakhovskaya, Irina, additional, Vos, Josephine M.I., additional, Patriarca, Andrea, additional, Mingot-Castellano, Maria Eva, additional, Giordano, Giulio, additional, Scarrone, Margherita, additional, Gonzalez-Lopez, Tomas Jose, additional, Trespidi, Laura, additional, Prati, Daniele, additional, and Barcellini, Wilma, additional

Published
2023
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19. Autoimmune hemolytic anemia during pregnancy and puerperium: an international multicenter experience

Author

Fattizzo, Bruno, Bortolotti, Marta, Fantini, Norma N., Glenthøj, Andreas, Michel, Marc, Napolitano, Mariasanta, Raso, Simona, Chen, Frederick, McDonald, Vickie, Murakhovskaya, Irina, Vos, Josephine Mathilde Iris, Patriarca, Andrea, Mingot-Castellano, Maria Eva, Giordano, Giulio, Scarrone, Margherita, González-López, Tomás José, Trespidi, Laura, Prati, Daniele, and Barcellini, Wilma

Published
2023
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20. Pttapp: An Application Developed By the Spanish Society of Hematology and Hemotherapy to Show Practical Recommendations on the Management of Immune TTP

Author

Mingot-Castellano, Maria Eva, primary, Goterris, Rosa, additional, Jiménez, Moraima, additional, Recasens, Valle, additional, Zalba, Saioa, additional, Fernandez-Docampo, Marta, additional, Fuentes, Ana Kerguelen, additional, Garcia-Arroba, Jose, additional, Gómez-Seguí, Inés, additional, Valcárcel, David, additional, and Pascual Izquierdo, Cristina, additional

Published
2022
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21. Thrombopoietin receptor agonists in adult Evans syndrome: an international multicenter experience

Author

Fattizzo, Bruno, primary, Cecchi, Nicola, additional, Bortolotti, Marta, additional, Giordano, Giulio, additional, Patriarca, Andrea, additional, Glenthøj, Andreas, additional, Cantoni, Silvia, additional, Capecchi, Marco, additional, Chen, Frederick, additional, Mingot-Castellano, Maria Eva, additional, Napolitano, Mariasanta, additional, Frederiksen, Henrik, additional, Gonzaléz-Lopez, Tomàs José, additional, and Barcellini, Wilma, additional

Published
2022
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23. Thrombopoietin receptor agonists in adult Evans syndrome:an international multicenter experience

Author

Fattizzo, Bruno, Cecchi, Nicola, Bortolotti, Marta, Giordano, Giulio, Patriarca, Andrea, Glenthøj, Andreas, Cantoni, Silvia, Capecchi, Marco, Chen, Frederick, Mingot-Castellano, Maria Eva, Napolitano, Mariasanta, Frederiksen, Henrik, Gonzaléz-Lopez, Tomàs José, Barcellini, Wilma, Fattizzo, Bruno, Cecchi, Nicola, Bortolotti, Marta, Giordano, Giulio, Patriarca, Andrea, Glenthøj, Andreas, Cantoni, Silvia, Capecchi, Marco, Chen, Frederick, Mingot-Castellano, Maria Eva, Napolitano, Mariasanta, Frederiksen, Henrik, Gonzaléz-Lopez, Tomàs José, and Barcellini, Wilma

Published
2022

24. Real-World Rates of Bleeding, Factor VIII Use, and Quality of Life in Individuals with Severe Haemophilia A Receiving Prophylaxis in a Prospective, Noninterventional Study

Author

Kenet, Gili, primary, Chen, Yeu-Chin, additional, Lowe, Gillian, additional, Percy, Charles, additional, Tran, Huyen, additional, von Drygalski, Annette, additional, Trossaërt, Marc, additional, Reding, Mark, additional, Oldenburg, Johannes, additional, Mingot-Castellano, Maria Eva, additional, Park, Young-Shil, additional, Peyvandi, Flora, additional, Ozelo, Margareth C., additional, Mahlangu, Johnny, additional, Quinn, Jennifer, additional, Huang, Mei, additional, Reddy, Divya B., additional, and Kim, Benjamin, additional

Published
2021
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25. FVIII inhibitor development according to concentrate: data from the EUHASS registry excluding overlap with other studies

Author

Fischer, K., Iorio, A., Hollingsworth, R., Makris, M., Watson, Henry, Rae, Joan, Platokouki, Helen, Pergantou, Helen, Katsarou, Olga, Theodossiades, George, Nomikou, Efrosyni, Parra, Rafael, Alonso, Sofia, Klamroth, Robert, Kubicek, Cornelia, Wilde, Jonathan, Dunkley, Tracey, Oldenburg, Johannes, Schmickler, Daniela, Ackroyd, Sam, Mirza, Lubena, Batorova, Angelika, Jankovicova, Denisa, Auerswald, Günter, Buehrlen, Martina, Penka, Miroslav, Smejkal, Petr, Blatny, Jan, Zapletal, Ondrej, Hermans, Cedric, Lambert, Catherine, Tagariello, Giuseppe, Radossi, Paolo, Nolan, Beatrice, Brady, Bridin, O'Donnell, James, Singleton, Evelyn, Shea, Irma, Morfini, Massimo, Linari, Silvia, de Moerloose, Philippe, Boehlen, Francoise, Campbell Tait, R., Brodie, Nancy, Chalmers, Elizabeth, Gibson, Aileen, Meijer, Karina, Tamminga, Rienk, Lassila, Riitta, Armstrong, Elina, Zulfikar, Bulent, Ozdemir, Nihal, Kavakli, Kaan, Balkan, Can, Jurgutis, Romualdas, Gailiute, Neringa, Peerlinck, Kathelijne, Van Geet, Chris, Goudemand, Jenny, Wibaut, Bénédicte, Joao Diniz, Maria, Antunes, Margarida, Liesner, Ri, Khair, Kate, Laffan, Mike, Patel, Sanjay, Thynn Yee, Thynn, Harrington, Christine, Pasi, John, Bowles, Louise, Bevan, David, Madan, Bella, Negrier, Claude, Ringenbach, Stéphanie, Mingot Castellano, Maria Eva, Astermark, Jan, Lindvall, Karin, Gatt, Alexander, Hay, Charles RM, Grey, Paula, Will, Andrew, Hague, Allyson, Peyvandi, Flora, Mancuso, Maria Elisa, Schved, Jean Francois, Rousseau, Florence, Kurnik, Karin, Bidlingmaier, Christoph, Rocino, Angiola, Hanley, John, Talks, Kate, Antoniades, Marios, Zanon, Ezio, De Bon, Emiliano, Lambert, Thierry, Rothschild, Chantal, Matingou, Marcelline, Tagliaferri, Annarita, Rivolta, Gianna Franca, Marchesini, Emanuela, Fraga, Cristina, Cunha-Ribeiro, Luís, Carvalho, Manuela, Komrska, Vladimir, Pindurova, Ester, Lejniece, Sandra, Kluce, Gunta, Leebeek, Frank, Cnossen, Marjon, Lockley, Caryl, Payne, Jeanette, Vidler, Vicky, Lissitchkov, Toshko, Raia, Petrova, Holmström, Margareta, Garipidou, Vassileia, Vakalopoulou, Sofia, Serban, Margit, Mihailov, Maria-Delia, Schinco, Piercarla, Valeri, Federica, Schutgens, Roger, Bonanad, Santiago, Cid, Ana Rosa, Castaman, Giancarlo, Pabinger, Ingrid, Reitter, Sylvia-Elisabeth, Male, Christoph, Thom, Katharina, Windyga, Jerzy, Piorowski, Michal, Schmugge, Markus, and Albisetti, Manuela

Published
2016
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26. The factor VIII treatment history of non‐severe hemophilia A: COMMENT. Joint damage in adult patients with mild or moderate hemophilia A evaluated with the HEAD‐US system

Author

Álvarez Román, María Teresa, de la Corte Rodríguez, Hortensia, Bonanad Boix, Santiago, Mingot‐Castellano, María Eva, Fernández Mosteirín, Nuria, Martín Salces, Mónica, Querol, Felipe, Canaro, Mariana, Santamaría, Amparo, Núñez, Ramiro, Frade, Luis Javier García, Martinoli, Carlo, Kim, Hae Kyung, and Jiménez‐Yuste, Víctor

Published
2021
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28. Caplacizumab As New Paradigm-Changing Therapy for Patients with Autoimmune Thrombotic Thrombocytopenic Purpura (aTTP): Real-World Data from TTP Spanish Registry

Author

Garcia-Garcia, Irene, primary, Jiménez, Moraima, additional, Valcárcel, David, additional, Mingot-Castellano, Maria Eva, additional, Pascual Izquierdo, Maria Cristina, additional, Viejo, Aurora, additional, Lozano, Miquel, additional, Goterris, Rosa, additional, Martínez Nieto, Jorge, additional, Oliva, Ana, additional, Gómez-Seguí, Inés, additional, Hernandez, Luis, additional, Zalba, Saioa, additional, Campuzano, Verónica, additional, Martínez, Yolanda, additional, González, Helena, additional, Tallon, Inmaculada, additional, Fernández Zarzoso, Miguel, additional, Moreno Jiménez, Gemma, additional, Lakhwani Lakhwani, Sunil, additional, Ortega, Sandra, additional, Solé, María, additional, Atucha Fernández, Jon Ander, additional, Del Rio-Garma, Julio, additional, and Cid, Joan, additional

Published
2020
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29. Evans' Syndrome in Adults: An Observational Multicentre Study

Author

Fattizzo, Bruno, primary, Michel, Marc, additional, Giannotta, Juri Alessandro, additional, Lund Hansen, Dennis, additional, Lopez Rubio, Montserrat, additional, Sutto, Emanuele, additional, Bianchetti, Nicola, additional, Patriarca, Andrea, additional, Cantoni, Silvia, additional, Mingot-Castellano, Maria Eva, additional, McDonald, Vickie, additional, Capecchi, Marco, additional, Vos, Josephine M.I, additional, Bianchi, Paola, additional, Vianelli, Nicola, additional, Chen, Frederick, additional, Frederiksen, Henrik, additional, Gonzalez-Lopez, Tomas Jose, additional, and Barcellini, Wilma, additional

Published
2020
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30. Incidence, Diagnosis, and Outcome of Acquired Thrombotic Thrombocytopenic Purpura (aTTP): A Nationwide Survey By the Spanish Apheresis Group

Author

Pascual Izquierdo, Maria Cristina, primary, Del Rio-Garma, Julio, additional, De La Rubia, Javier, additional, Viejo, Aurora, additional, Fernandez-Sojo, Jesus, additional, Martin, Jesus, additional, Solanich, Xavier, additional, García-Candel, Faustino, additional, Hernandez, Luis, additional, Fernandez, Marta, additional, Oliva, Ana, additional, Garcia-Gala, Jose Maria, additional, Mingot-Castellano, Maria Eva, additional, Gomez-Seguí, Ines, additional, Goterris, Rosa, additional, Calviño, Michael, additional, Antelo, María Luisa, additional, Sanchez, Sol, additional, Moreno, Jose Antonio, additional, Amunarriz, Cristina, additional, Garcia-Arroba, Jose, additional, Fernandez, Carmen, additional, Alonso, Nieves, additional, Gonzalez, Victoria, additional, Guerra, Luisa, additional, Moreno, M. Elena, additional, M. Dolores, Moreno, additional, Moreno, Gemma, additional, Daorta, Melisa, additional, Chica, Esther, additional, Del Orbe, Rafael, additional, Cid, Joan, additional, Berberana, Margarita, additional, Ballester, Carmen, additional, Nistal Gil, Sara, additional, Vidan, Julia, additional, Calderon, Maite, additional, Martinez Redondo, Consuelo, additional, Hernandez, Jose Carlos, additional, Gordillo, Marina, additional, Salgado, Angel, additional, and Salinas, Ramon, additional

Published
2019
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31. Predictive Factors for Thrombopoietin Receptor Agonist Free Responses in Chronic ITP Patients: A Multicenter Retrospective Study with Long-Term Follow-up

Author

Lozano, Maria Luisa, primary, Mingot-Castellano, Maria Eva, additional, Perera, María, additional, Jarque, Isidro, additional, Campos, Rosa Maria, additional, González-López, Tomás José, additional, Carreño Gomez-Tarragona, Gonzalo, additional, Bermejo, Nuria, additional, Lopez Fernandez, Maria Fernanda, additional, de Andrés, Aurora, additional, Valcarcel, David, additional, Casado, Felipe, additional, Álvarez Roman, Teresa, additional, Orts, María Isabel, additional, Novelli, Silvana, additional, Revilla, Nuria, additional, González-Porras, Jose Ramon, additional, Bolaños, Estefanía, additional, Rodríguez López, Manuel, additional, Orna, Elisa, additional, and Garcia, Vicente Vicente, additional

Published
2019
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32. Do Guidelines Influence Diagnostic and Therapeutic Practice in Immune Thrombocytopenia? Results of a Multicenter Retrospective Study

Author

Lozano, Maria Luisa, primary, Mingot-Castellano, Maria Eva, additional, Perera, María, additional, Jarque, Isidro, additional, Campos, Rosa Maria, additional, González-López, Tomás José, additional, Carreño Gomez-Tarragona, Gonzalo, additional, Bermejo, Nuria, additional, Lopez Fernandez, Maria Fernanda, additional, de Andrés, Aurora, additional, Valcarcel, David, additional, Casado, Felipe, additional, Álvarez Roman, Teresa, additional, Orts, María Isabel, additional, Novelli, Silvana, additional, González-Porras, Jose Ramon, additional, Bolaños, Estefanía, additional, Rodríguez López, Manuel, additional, Orna, Elisa, additional, and Garcia, Vicente Vicente, additional

Published
2019
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33. Cross-Sectional Comparative Study of PK-Guided Switch between Standard Half-Life and Extended Half-Life Factor VIII Products

Author

Megias, Juan Eduardo, primary, Bonanad Boix, Santiago, additional, Martínez García, María Fernanda, additional, Berrueco, Rubén, additional, Mingot-Castellano, Maria Eva, additional, Rodríguez López, Manuel, additional, Canaro, Mariana, additional, Mateo Arranz, José, additional, Larrodé Leciñena, Itziar, additional, Haya, Saturnino, additional, Ortiz, Amparo Santamaria, additional, Albo, Carmen, additional, Mesegué Medea, Montserrat, additional, Palomero-Massanet, Antonio, additional, Vilalta Seto, Noelia, additional, Calvo Villas, José Manuel, additional, Cid, Ana R, additional, Robayo, Gustavo, additional, Poveda Andrés, José Luis, additional, Sanz, Guillermo F., additional, and Iorio, Alfonso, additional

Published
2019
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34. Influence of Age on Treatment with Thrombopoietin Receptor Agonists in Patients with Immune Thrombocytopenia; A Retrospective Multicenter Study

Author

Lozano, Maria Luisa, primary, Mingot-Castellano, Maria Eva, additional, Perera, María, additional, Jarque, Isidro, additional, Campos, Rosa Maria, additional, González-López, Tomás José, additional, Carreño Gomez-Tarragona, Gonzalo, additional, Bermejo, Nuria, additional, Lopez Fernandez, Maria Fernanda, additional, de Andrés, Aurora, additional, Valcarcel, David, additional, Casado, Felipe, additional, Álvarez Roman, Teresa, additional, Orts, María Isabel, additional, Novelli, Silvana, additional, González-Porras, Jose Ramon, additional, Bolaños, Estefanía, additional, Rodríguez López, Manuel, additional, Orna, Elisa, additional, and Garcia, Vicente Vicente, additional

Published
2019
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35. Fenotipo hemostático en mujeres portadoras de hemofilia A: Características del perfil hemorrágico y el riesgo cardiovascular. Repercusión en la calidad de vida relacionada con la salud

Author

Mingot-Castellano, Maria Eva, Medicina y Dermatología, Sánchez Chaparro, Miguel Ángel, Valdivielso Felices, Pedro, Sanchez-Chaparro, Miguel Angel, and Valdivielso-Felices, Pedro

Subjects
ISTH-BAT, Calidad de vida, Hemofilia - Tesis doctorales, Factores de riesgo vascular, Portadoras
Abstract

La hemofilia A congénita es una coagulopatía hemorrágica secundaria al déficit cuantitativo del factor VIII (FVIII) de la coagulación. Su transmisión está ligada al cromosoma X, expresándose clínicamente en los varones, en mayor o menor intensidad según la gravedad de la hemofilia. Las mujeres portadoras han sido valoradas tradicionalmente como transmisoras de una enfermedad crónica y cuidadoras de los sujetos afectos. Sin embargo, existen portadoras de hemofilia A con niveles de FVIII descendido y expresión hemorrágica. El colectivo de mujeres portadoras de hemofilia A es reducido. Tenemos escasa información sobre un posible fenotipo hemorrágico propio o cuales son los niveles de factor VIII (FVIII) que lo condicionan. Desconocemos el riesgo vascular (RCV) de estas mujeres y el grado de calidad de vida como individuos, no como cuidadoras de sujetos con una patología crónica. OBJETIVOS: • Identificar el posible perfil hemorrágico de las portadoras de hemofilia A estudiadas. • Valorar las variaciones del perfil hemorrágico de las portadoras según los niveles de FVIII que presenten. • Evaluar la prevalencia de factores de riesgo vascular y calcular el riesgo vascular de las mujeres portadoras de hemofilia A en nuestro medio. • Comparar la prevalencia de factores de riesgo vascular y el riesgo vascular de las portadoras de hemofilia A y un grupo de controles sin coagulopatía. • Analizar la calidad de vida y estado de ansiedad/depresión de las portadoras estudiadas, comparándolo con el de la población general. MÉTODO: Estudio observacional, transversal y descriptivo de un solo centro (Hospital Regional Universitario de Málaga). Ha sido aprobado por el Comité Ético del Centro y todas las pacientes y los controles han dado su consentimiento por escrito para la inclusión. Hemos analizado antecedentes de eventos cardiovasculares y trombóticos familiares y personales, perfil hemorrágico (International Society of Thrombosis and Hemostasis Bleeding Assessment, ISTH BAT, y el Pictorial Blood Assessment Chart, PBAC), alteración genética responsable de la hemofilia, hemograma, bioquímica básica, estudio de hemostasia básica y primaria, y trombofilia. En relación al RCV, hemos analizado los parámetros de riesgo, la prevalencia de factores de riesgo (FRV), estimado el RCV global (Framingham, SCORE europeo) y la edad vascular (Framingham; SCORE europeo). La calidad de vida ha sido evaluada usando el cuestionario SF-36 (versión española 1,4 1999). Para la valoración del estado de ansiedad y depresión, hemos utilizado el Cuestionario Goldberg y cols., 1998 (versión española Gzempp, 1993). Los controles, procedentes del Centro de Prevención de Riesgos Laborales de Málaga, han sido evaluados del mismo modo, con la excepción de los estudios de laboratorio de hemostasia. Sólo en los controles con ISTH BAT patológico (superior a 5) se han realizado estudios de hemostasia básica y primaria. RESULTADOS: Sobre un total de 81 portadoras de hemofilia A identificadas, entre agosto de 2012 y diciembre de 2013 hemos evaluado a 69 de ellas. Las 138 controles fueron incluidas entre septiembre de 2013 y junio de 2014. Solo 7 de las portadoras, y ningún control, presentaron un ISTH-BAT patológico. De estas 7 portadoras sintomáticas, una tiene una enfermedad de von Willebränd asociada y otra una trombopatía aspirin-like que no eran conocidas. En las 5 restantes no hay justificación para el sangrado desde el punto de vista de las pruebas de laboratorio realizadas. El grupo de portadoras presentó una mayor incidencia de sangrado anormal en heridas, extracciones dentarias, cirugías y menorragia. Encontramos un perfil de sangrado diferente entre las portadoras en base a los niveles de FVIII que presentaban (menor o mayor de 60%). Existe una mayor prevalencia de FRV en las portadoras de hemofilia A respecto a las controles, y un mayor RCV en todas las escalas evaluadas. Estas diferencias se hacen estadísticamente significativa en el escore de Framingham y SCORE 2003. Una posible justificación para ello podría ser la mayor prevalencia de diabetes entre las portadoras de hemofilia A analizadas. Las portadoras con FVIII menor o igual al 60%, presentaron menor RCV respecto a aquellas con niveles superiores de FVIII. En lo referente a calidad de vida, la población de portadoras presenta menor puntuación en los dominios de actividad social y salud mental. La prevalencia de ansiedad y depresión fue mayor en el grupo de controles. CONCLUSIONES: En nuestra experiencia, el conjunto de mujeres portadoras de hemofilia A presentan un perfil hemorrágico característico y una prevalencia de sangrado mayor a la población normal. En la población de portadoras de hemofilia A analizada, encontramos mayor prevalencia de FRV (especialmente los relacionados con la resistencia insulínica), mayor prevalencia de estratos de RCV elevados (moderado-alto) y mayor edad vascular que las controles. Existen matices diferenciales en los parámetros de calidad de vida; así como en la prevalencia de ansiedad-depresión, en las portadoras de hemofilia respecto a las controles.

Published
2017

37. Straightforward Transition to Bay 81-8973 Prophylaxis in Patients with Hemophilia A: Prospective Real-World Data from the Taurus Non-Interventional Study Show That Number of Infusions per Week Is Maintained or Reduced

Author

Wang, Michael, primary, Fuh, Beng, additional, Maes, Philip, additional, Mingot-Castellano, Maria Eva, additional, Berrueco, Rubén, additional, Le, Phu-Quoc, additional, Rauchensteiner, Stephan, additional, and Santoro, Cristina, additional

Published
2018
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38. Multirefractory primary immune thrombocytopenia; targeting the decreased sialic acid content

Author

Revilla, Nuria, primary, Corral, Javier, additional, Miñano, Antonia, additional, Mingot-Castellano, Maria Eva, additional, Campos, Rosa Maria, additional, Velasco, Francisco, additional, Gonzalez, Nicolas, additional, Galvez, Eva, additional, Berrueco, Ruben, additional, Fuentes, Inmaculada, additional, Gonzalez-Lopez, Tomas Jose, additional, de la Morena-Barrio, Maria Eugenia, additional, Gonzalez-Porras, Jose Ramon, additional, Vicente, Vicente, additional, and Lozano, Maria Luisa, additional

Published
2018
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39. The predictive value of factor VIII/factor IX levels to define the severity of hemophilia: communication from the SSC of ISTH

Author

Mancuso, M.E., primary, Bidlingmaier, C., additional, Mahlangu, J.N., additional, Carcao, M., additional, Tosetto, A., additional, Kurnik, Karin, additional, Blatny, Jan, additional, Castaman, Giancarlo, additional, Linari, Silvia, additional, Cid, Ana Rosa, additional, Dargaud, Yesim, additional, Grabell, Julie, additional, James, Paula, additional, Holzhauer, Suzanne, additional, Kavakli, Kaan, additional, Kenet, Gili, additional, Key, Nigel, additional, Abajas, Yasmina, additional, Ming, Lim, additional, Mingot‐Castellano, Maria Eva, additional, Ozelo, Margaret, additional, Pabinger, Ingrid, additional, Santoro, Cristina, additional, Tagliaferri, Annarita, additional, and Klukowska, Anna, additional

Published
2018
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43. Characterization of Bleeding in Hemophilia Carriers and Comparison to Women with Type 1 Von Willebrand Disease, Type 3 Von Willebrand Disease Obligate Carriers and Controls

Author

Satkunam, Natasha Amrita, primary, Mahlangu, Johnny, additional, Bidlingmaier, Christoph, additional, Mingot-Castellano, Maria Eva, additional, Chitlur, Meera B., additional, Fogarty, Patrick F., additional, Cuker, Adam, additional, Mancuso, Maria Elisa, additional, Holme, Pal André, additional, Grabell, Julie, additional, Hopman, Wilma, additional, Mathew, Prasad, additional, and James, Paula D., additional

Published
2016
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44. Multirefractory primary immune thrombocytopenia; targeting the decreased sialic acid content.

Author

Revilla, Nuria, Corral, Javier, Miñano, Antonia, Mingot-Castellano, Maria Eva, Campos, Rosa Maria, Velasco, Francisco, Gonzalez, Nicolas, Galvez, Eva, Berrueco, Ruben, Fuentes, Inmaculada, Gonzalez-Lopez, Tomas Jose, de la Morena-Barrio, Maria Eugenia, Gonzalez-Porras, Jose Ramon, Vicente, Vicente, and Lozano, Maria Luisa

Subjects
THROMBOPOIETIN receptors, SIALIC acids, IDIOPATHIC thrombocytopenic purpura, BLOOD proteins, BLOOD platelet activation, ANTIVIRAL agents
Abstract

Patients with multirefractory immune thrombocytopenia (ITP) have limited treatment options. Recent data suggest that specific anti-platelet antibodies may cause destruction of platelets by favoring platelet loss of sialic acid. In this multicenter study 35 patients with ITP, including 16 with multirefractory disease, were analyzed for antiplatelet-antibodies, thrombopoietin (TPO) levels, and platelet desialylation. In selected cases, responses to a novel treatment strategy using oseltamivir were tested. We found that antibodies against GPIbα were overrepresented in multirefractory patients compared to responders (n = 19). In contrast to conventional ITP patients, multirefractory patients exhibited a significant increased platelet activation state (granule secretion) and desialylation (RCA-1 binding) (p < 0.05), and a trend toward higher plasma TPO concentrations. The decreased sialic acid content seemed to be restricted to platelet glycoproteins, since other plasma proteins were not hypoglycosylated. A total of 10 patients with multirefractory ITP having remarkable loss of platelet terminal sialic acids were given oseltamivir phosphate. When the antiviral drug was combined with TPO receptor agonists (TPO-RAs) or with immunosuppressant drugs, platelet responses were observed in 66.7% of patients. All responding patients presented with antibodies reactive only against GPIbα. These findings suggest that desialylation may play a key pathogenic role in some multirefractory ITP patients, and provide diagnostic tools for the identification of such patients. Furthermore, we show that sialidase inhibitor treatment in combination with therapies that help to increase platelet production can induce sustained platelet responses in some patients with anti-GPIbα -mediated thrombocytopenia that have failed previous therapies. [ABSTRACT FROM AUTHOR]

Published
2019
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46. Caplacizumab Treatment in Elderly Patients with iTTP: Updated Experience from the Spanish TTP Registry

Author

Gómez Seguí, Inés, Sopeña Pell-Ilderton, Clara, Cid, Joan, Lozano, Miquel, Mingot Castellano, Maria Eva, Pascual Izquierdo, Maria Cristina, Gonzalez del Castillo, Luz Maria, Vidan Estevez, Julia Maria, Garcia-Candel, Faustino, Jiménez Balarezo, Moraima, Valcarcel, David, Cuellar Perez-Avila, Clara, Aguirre Arrizabalaga, Maria Aranzazu, Avila Idrovo, Laura Francisca, Moreno Jimenez, Maria Gemma, Oliva Hernandez, Ana Yurena, Garcia Gala, Jose Maria, Martínez Nieto, Jorge, Goterris, Rosa, Fernández Docampo, Marta, and De La Rubia, Javier

Abstract

Introduction

Published
2023
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49. Safety Of Splenectomy In Hematological Diseases

Author

Moragues Martinez, Maria Cristina, primary, Hurst, Kati, additional, Mingot Castellano, Maria Eva, additional, Ruiz, Jose Coin, additional, Prieto Sanchez, Maria Elisa, additional, Mancha, Isabel Vidales, additional, Pareja, Macarena Ortiz, additional, Espeso de Haro, Manuel, additional, Bautista Ojeda, Maria Dolores, additional, and Heiniger Mazo, Ana Isabel, additional

Published
2013
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