149 results on '"Minghui Yao"'
Search Results
2. Identification and validation of key genes associated with atrial fibrillation in the elderly
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Chuanbin Liu, Jing Zeng, Jin Wu, Jing Wang, Xin Wang, Minghui Yao, Minghua Zhang, and Jiao Fan
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atrial fibrillation ,hub genes ,weighted gene co-expression network analysis ,elderly ,biomarkers ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundAtrial fibrillation (AF) is the most common cardiac arrhythmia and significantly increases the risk of stroke and heart failure (HF), contributing to a higher mortality rate. Increasing age is a major risk factor for AF; however, the mechanisms of how aging contributes to the occurrence and progression of AF remain unclear. This study conducted weighted gene co-expression network analysis (WGCNA) to identify key modules and hub genes and determine their potential associations with aging-related AF.Materials and methodsWGCNA was performed using the AF dataset GSE2240 obtained from the Gene Expression Omnibus, which contained data from atrial myocardium in cardiac patients with permanent AF or sinus rhythm (SR). Hub genes were identified in clinical samples. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were also performed.ResultsGreen and pink were the most critical modules associated with AF, from which nine hub genes, PTGDS, COLQ, ASTN2, VASH1, RCAN1, AMIGO2, RBP1, MFAP4, and ALDH1A1, were hypothesized to play key roles in the AF pathophysiology in elderly and seven of them have high diagnostic value. Functional enrichment analysis demonstrated that the green module was associated with the calcium, cyclic adenosine monophosphate (cAMP), and peroxisome proliferator-activated receptors (PPAR) signaling pathways, and the pink module may be associated with the transforming growth factor beta (TGF-β) signaling pathway in myocardial fibrosis.ConclusionWe identified nine genes that may play crucial roles in the pathophysiological mechanism of aging-related AF, among which six genes were associated with AF for the first time. This study provided novel insights into the impact of aging on the occurrence and progression of AF, and identified biomarkers and potential therapeutic targets for AF.
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- 2023
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3. Road crack segmentation using an attention residual U-Net with generative adversarial
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Xing Hu, Minghui Yao, and Dawei Zhang
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road crack segmentation ,attention residual u-net ,adversarial learning ,Biotechnology ,TP248.13-248.65 ,Mathematics ,QA1-939 - Abstract
This paper proposed an end-to-end road crack segmentation model based on attention mechanism and deep FCN with generative adversarial learning. We create a segmentation network by introducing a visual attention mechanism and residual module to a fully convolutional network(FCN) to capture richer local features and more global semantic features and get a better segment result. Besides, we use an adversarial network consisting of convolutional layers as a discrimination network. The main contributions of this work are as follows: 1) We introduce a CNN model as a discriminate network to realize adversarial learning to guide the training of the segmentation network, which is trained in a min-max way: the discrimination network is trained by maximizing the loss function, while the segmentation network is trained with the only gradient passed by the discrimination network and aim at minimizing the loss function, and finally an optimal segmentation network is obtained; 2) We add the residual modular and the visual attention mechanism to U-Net, which makes the segmentation results more robust, refined and smooth; 3) Extensive experiments are conducted on three public road crack datasets to evaluate the performance of our proposed model. Qualitative and quantitative comparisons between the proposed method and the state-of-the-art methods show that the proposed method outperforms or is comparable to the state-of-the-art methods in both F1 score and precision. In particular, compared with U-Net, the mIoU of our proposed method is increased about 3%~17% compared with the three public datasets.
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- 2021
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4. POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function
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Minghui Yao, Meizhen Meng, Xiyu Yang, Shuo Wang, Hongsheng Zhang, Feng Zhang, Lei Shi, Yongqing Zhang, Xiaohui Zhang, and Zhiheng Xu
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CP: Neuroscience ,Biology (General) ,QH301-705.5 - Abstract
Summary: Mutation or disruption of the Shank/ProSAP family of genes is a high risk factor for autism spectrum disorders (ASDs) and intellectual disability. N-methyl-D-aspartate glutamate receptor (NMDAR) dysfunction contributes to the development of autism-like behaviors. However, the molecular mechanism of Shank-mediated NMDAR modulation is still not clear. Here, we show that the scaffold protein plenty of SH3s (POSH) directly interacts with two other scaffold proteins, PSD95 and SHANK2/3, at excitatory synapses. In POSH conditional knockout (cKO) mice, normal synaptic clustering of NMDAR/PSD-95/SHANK complex is disrupted, accompanied by abnormal dendritic spine development and glutamatergic transmission in hippocampal neurons. POSH cKO mice display profound autism-like behaviors, including impairments in social interactions, social communication, repetitive behaviors, and deficits in learning and memory. Thus, POSH clusters at the postsynaptic density (PSD) with PSD-95 and SHANK2/3 and plays important roles in the signaling mechanisms of the NMDAR/PSD-95/POSH/SHANK complex as well as in spine development and brain function.
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- 2022
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5. A Novel Aerodynamic Force and Flutter of the High-Aspect-Ratio Cantilever Plate in Subsonic Flow
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Li Ma, Minghui Yao, Wei Zhang, Kai Lou, Dongxing Cao, and Yan Niu
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Physics ,QC1-999 - Abstract
This paper focuses on the derivation of the aerodynamic force for the cantilever plate in subsonic flow. For the first time, a new analytical expression of the quasi-steady aerodynamic force related to the velocity and the deformation for the high-aspect-ratio cantilever plate in subsonic flow is derived by utilizing the subsonic thin airfoil theory and Kutta-Joukowski theory. Results show that aerodynamic force distribution obtained theoretically is consistent with that calculated by ANSYS FLUENT. Based on the first-order shear deformation and von Karman nonlinear geometric relationship, nonlinear partial differential dynamical equations of the high-aspect-ratio plate subjected to the aerodynamic force are established by using Hamilton’s principle. Galerkin approach is applied to discretize the governing equations to ordinary differential equations. Numerical simulation is utilized to investigate the relation between the critical flutter velocity and some parameters of the system. Results show that when the inflow velocity reaches the critical value, limit cycle oscillation occurs. The aspect ratio, the thickness, and the air damping have significant impact on the critical flutter velocity of the thin plate.
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- 2020
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6. Nonlinear Dynamics and Power Generation on a New Bistable Piezoelectric-Electromagnetic Energy Harvester
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Minghui Yao, Pengfei Liu, and Hongbo Wang
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Electronic computers. Computer science ,QA75.5-76.95 - Abstract
This paper focuses power generation and nonlinear dynamic behaviors on a new bistable piezoelectric-electromagnetic energy harvester. Three different kinds of piezoelectric cantilever beam structures, which include the monostable piezoelectric cantilever beam, the bistable piezoelectric cantilever beam with spring and magnet, and the bistable piezoelectric cantilever beam with spring, magnet, and coil, are designed. The power generation efficiency and dynamic behaviors for each structure are experimentally studied, respectively. Due to the spring introduced, the system easily goes through the potential barrier. Experimental results show that the power generation structure of the bistable piezoelectric-electromagnetic harvester can vibrate between two steady states in a wider range of the frequency. Therefore, the effective frequency bandwidth is broadened about 2 Hz when the spring is introduced under the condition of the suitable magnetic distance. Comparing with the power generation efficiency for three different kinds of structures, it is found that the bistable piezoelectric-electromagnetic harvester has the optimum characteristics, which include the optimal magnetic distance of 15 mm, the optimal load of 8 MΩ, and the parameters variation law of coils. For this structure, the influences of the external excitation and the magnetic distance on the output voltage and dynamic behaviors of the system are examined.
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- 2020
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7. MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis.
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Dan Xu, Minghui Yao, Yaqing Wang, Ling Yuan, Joerg D Hoeck, Jingwen Yu, Liang Liu, Yvonne Y C Yeap, Weiya Zhang, Feng Zhang, Yinghang Feng, Tiantian Ma, Yujie Wang, Dominic C H Ng, Xiaoyin Niu, Bing Su, Axel Behrens, and Zhiheng Xu
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Biology (General) ,QH301-705.5 - Abstract
Mutations of WD repeat domain 62 (WDR62) lead to autosomal recessive primary microcephaly (MCPH), and down-regulation of WDR62 expression causes the loss of neural progenitor cells (NPCs). However, how WDR62 is regulated and hence controls neurogenesis and brain size remains elusive. Here, we demonstrate that mitogen-activated protein kinase kinase kinase 3 (MEKK3) forms a complex with WDR62 to promote c-Jun N-terminal kinase (JNK) signaling synergistically in the control of neurogenesis. The deletion of Mekk3, Wdr62, or Jnk1 resulted in phenocopied defects, including premature NPC differentiation. We further showed that WDR62 protein is positively regulated by MEKK3 and JNK1 in the developing brain and that the defects of wdr62 deficiency can be rescued by the transgenic expression of JNK1. Meanwhile, WDR62 is also negatively regulated by T1053 phosphorylation, leading to the recruitment of F-box and WD repeat domain-containing protein 7 (FBW7) and proteasomal degradation. Our findings demonstrate that the coordinated reciprocal and bidirectional regulation among MEKK3, FBW7, WDR62, and JNK1, is required for fine-tuned JNK signaling for the control of balanced NPC self-renewal and differentiation during cortical development.
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- 2018
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8. Sh3rf2 Haploinsufficiency Leads to Unilateral Neuronal Development Deficits and Autistic-Like Behaviors in Mice
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Shuo Wang, Ningdong Tan, Xingliang Zhu, Minghui Yao, Yaqing Wang, Xiaohui Zhang, and Zhiheng Xu
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Biology (General) ,QH301-705.5 - Abstract
Summary: Autism spectrum disorders (ASDs) include a variety of developmental brain disorders with clinical findings implicating the dysfunction of the left hemisphere. Here, we generate mice lacking one copy of Sh3rf2, which was detected in ASD patients, to determine whether Sh3rf2 is involved in brain development and whether mutation of SH3RF2 is causative for ASD and the mechanisms linking it to ASD traits. We find that mice with Sh3rf2 haploinsufficiency display significant deficits in social interaction and communication, as well as stereotyped or repetitive behaviors and hyperactivity and seizures. Disturbances in hippocampal dendritic spine development, aberrant composition of glutamatergic receptor subunits, and abnormal excitatory synaptic transmission were detected in heterozygous mutants. Remarkably, these defects are selectively unilateral. Our results support a notion that Sh3rf2 haploinsufficiency is a highly penetrant risk factor for ASD, with disease pathogenesis most likely resulting from deficits in synaptic function in the left hemisphere of the brain. : Wang et al. find that Sh3rf2 is important for neuron development and that Sh3rf2 haploinsufficiency in mice results in typical ASD-like behaviors, as well as selective unilateral disturbances in hippocampal dendritic spine development, composition of glutamatergic receptor subunits, and excitatory synaptic transmission. Keywords: autism spectrum disorders, Sh3rf2/POSHER, brain development, synaptic function
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- 2018
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9. Method Bias Mechanisms and Procedural Remedies
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Minghui Yao and Yunjie Xu
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As a crucial method in organizational and social behavior research, self-report surveys must manage method bias. Method biases are distorted scores in survey response, distorted variance in variables, and distorted relational estimates between variables caused by method designs. Studies on method bias have focused on "post hoc" statistical control, but integrated analyses of the sociopsychological mechanism of method bias are lacking. This review proposes a framework for method bias and offers a relatively complete and detailed review of the sociopsychological and statistical mechanisms of four main types of method bias and their procedural remedies. This review proposes "reduce, remove, and rectify" as a guideline for researchers in survey design to address method bias. Finally, this review presents two directions for future methodology research.
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- 2024
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10. Nonlinear Dynamics of the High-Speed Rotating Plate
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Minghui Yao, Li Ma, and Wei Zhang
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Motor vehicles. Aeronautics. Astronautics ,TL1-4050 - Abstract
High speed rotating blades are crucial components of modern large aircraft engines. The rotating blades under working condition frequently suffer from the aerodynamic, elastic and inertia loads, which may lead to large amplitude nonlinear oscillations. This paper investigates nonlinear dynamic responses of the blade with varying rotating speed in supersonic airflow. The blade is simplified as a pre-twist and presetting cantilever composite plate. Warping effect of the rectangular cross-section of the plate is considered. Based on the first-order shear deformation theory and von-Karman nonlinear geometric relationship, nonlinear partial differential dynamic equations of motion for the plate are derived by using Hamilton’s principle. Galerkin approach is applied to discretize the partial differential governing equations of motion to ordinary differential equations. Asymptotic perturbation method is exploited to derive four-degree-of-freedom averaged equation for the case of 1 : 3 internal resonance-1/2 sub-harmonic resonance. Based on the averaged equation, numerical simulation is used to analyze the influence of the perturbation rotating speed on nonlinear dynamic responses of the blade. Bifurcation diagram, phase portraits, waveforms and power spectrum prove that periodic motion and chaotic motion exist in nonlinear vibration of the rotating cantilever composite plate.
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- 2018
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11. Nonlinear Dynamics of Imperfect FGM Conical Panel
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Yan Niu, Yuxin Hao, Minghui Yao, Wei Zhang, and Shaowu Yang
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Physics ,QC1-999 - Abstract
Structures composed of functionally graded materials (FGM) can satisfy many rigorous requisitions in engineering application. In this paper, the nonlinear dynamics of a simply supported FGM conical panel with different forms of initial imperfections are investigated. The conical panel is subjected to the simple harmonic excitation along the radial direction and the parametric excitation in the meridian direction. The small initial geometric imperfection of the conical panel is expressed by the form of the Cosine functions. According to a power-law distribution, the effective material properties are assumed to be graded along the thickness direction. Based on the first-order shear deformation theory and von Karman type nonlinear geometric relationship, the nonlinear equations of motion are established by using the Hamilton principle. The nonlinear partial differential governing equations are truncated by Galerkin method to obtain the ordinary differential equations along the radial displacement. The effects of imperfection types, half-wave numbers of the imperfection, amplitudes of the imperfection, and damping on the dynamic behaviors are studied by numerical simulation. Maximum Lyapunov exponents, bifurcation diagrams, time histories, phase portraits, and Poincare maps are obtained to show the dynamic responses of the system.
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- 2018
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12. Pharmacokinetics and pharmacodynamics of recombinant human EPO-Fc fusion protein in vivo.
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Xunlong Shi, Jianjun Yang, Haiyan Zhu, Li Ye, Meiqing Feng, Jiyang Li, Hai Huang, Qun Tao, Dan Ye, Lee-Hwei K Sun, Bill N C Sun, Cecily R Y Sun, Guizhen Han, Yuanyuan Liu, Minghui Yao, Pei Zhou, and Dianwen Ju
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Medicine ,Science - Abstract
In this study, the in vivo pharmacokinetics and pharmacodynamics of a novel recombinant human erythropoietin (rhEPO) Fc fusion protein, rhEPO-Fc, were studied in both rodents and rhesus monkeys. Animal models of anemia induced by irradiation, cyclophosphamide and partial renal ablation were used to evaluate therapeutic effects of rhEPO-Fc. We have demonstrated that serum half-life of rhEPO-Fc was 29.5 to 38.9 h at doses of 8, 25, 80 µg/kg in rhesus monkeys and 35.5 to 43.5 h at doses of 16, 50, 160 µg/kg in rats. In anemia animal models, rhEPO-Fc dose-dependently (7.5-30.0 µg/kg in mice, 5.4-21.4 µg/kg in rats and 5.0-10.0 µg/kg in rhesus monkeys) increased reticulocyte level, followed by an increase of RBC count, hemoglobin and hematocrit levels. At reduced intervention frequency of weekly treatments, rhEPO-Fc showed similar hematopoietic effects as compared with rhEPO given three times a week. These results indicated that rhEPO-Fc could potentially be used in treatment of anemia and warrants future clinical trials.
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- 2013
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13. Multipulse Heteroclinic Orbits and Chaotic Dynamics of the Laminated Composite Piezoelectric Rectangular Plate
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Minghui Yao and Wei Zhang
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Mathematics ,QA1-939 - Abstract
This paper investigates the multipulse global bifurcations and chaotic dynamics for the nonlinear oscillations of the laminated composite piezoelectric rectangular plate by using an energy phase method in the resonant case. Using the von Karman type equations, Reddy’s third-order shear deformation plate theory, and Hamilton’s principle, the equations of motion are derived for the laminated composite piezoelectric rectangular plate with combined parametric excitations and transverse excitation. Applying the method of multiple scales and Galerkin’s approach to the partial differential governing equation, the four-dimensional averaged equation is obtained for the case of 1 : 2 internal resonance and primary parametric resonance. The energy phase method is used for the first time to investigate the Shilnikov type multipulse heteroclinic bifurcations and chaotic dynamics of the laminated composite piezoelectric rectangular plate. The paper demonstrates how to employ the energy phase method to analyze the Shilnikov type multipulse heteroclinic bifurcations and chaotic dynamics of high-dimensional nonlinear systems in engineering applications. Numerical simulations show that for the nonlinear oscillations of the laminated composite piezoelectric rectangular plate, the Shilnikov type multipulse chaotic motions can occur. Overall, both theoretical and numerical studies suggest that chaos for the Smale horseshoe sense in motion exists.
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- 2013
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14. Node Switching Strategy For Quantum Air Communication Network Of Imitation Goose Swarm Array.
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Minghui Yao, Min Nie, Guang Yang, and Jingyu Wang
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- 2023
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15. Analysis of the Effect of Atmospheric Turbulence on the Performance of Free-space Quantum Signal Transmission.
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Yan Kang, Min Nie, Changchun Xue, and Minghui Yao
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- 2023
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16. Nonreciprocity of energy transfer in a nonlinear asymmetric oscillator system with various vibration states
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Jian’en Chen, Jianling Li, Minghui Yao, Jun Liu, Jianhua Zhang, and Min Sun
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Mechanics of Materials ,Applied Mathematics ,Mechanical Engineering - Published
- 2023
17. Community-Based Message Transmission with Energy Efficient in Opportunistic Networks.
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Sheng Zhang 0011, Xin Wang, Minghui Yao, and William Wei Song
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- 2016
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18. Stability Analysis and Nonlinear Vibrations of the Ring Truss Antenna with the Six-Dimensional System
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Jingyi Liu, Ying Sun, Minghui Yao, and Jianguang Ma
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General Engineering ,General Earth and Planetary Sciences ,General Environmental Science - Published
- 2022
19. Nonlinear vibrations of functionally graded graphene reinforced composite cylindrical panels
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Qiliang Wu, Yan Niu, and Minghui Yao
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Backward differentiation formula ,Partial differential equation ,Materials science ,Applied Mathematics ,Mathematical analysis ,Vibration ,symbols.namesake ,Nonlinear system ,Modeling and Simulation ,Ordinary differential equation ,symbols ,Hamilton's principle ,Galerkin method ,Material properties - Abstract
The present paper is concerned with nonlinear vibration of a simply supported functionally graded graphene reinforced composite (GRC) cylindrical panel subjected to the transverse excitation. Functionally graded structure is proposed to distribute more graphene platelets (GPLs) to the most needed layer for the optimal performance. The modified Halpin-Tsai model and the rule of mixture are carried out to predict the effective material properties of the GRC cylindrical panel, such as Young's modulus, Poisson's ratio and mass density. Nonlinear partial differential equations of motion are established within the framework of Hamilton principle in conjunction with first-order shear deformation theory (FSDT) and von Karman geometric nonlinearity. Navier approach is adopted to calculate natural frequencies of the GRC cylindrical panel. Then, considering the external excitation, Galerkin method is applied to realize the model reduction, which is expressed by the ordinary differential equations. Backward Differentiation Formula (BDF) is used to perform nonlinear transient responses of the system subjected to the pulse excitation (step load or triangular load). Finally, Runge-Kutta method is employed to carry out bifurcations and chaotic dynamics of the system subjected to the steady-state excitation. Results are presented in the form of natural frequencies and nonlinear responses to perform the parametric studies, such as distribution types and weight fractions of GPLs, geometry parameters and excitation parameters of the GRC cylindrical panel.
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- 2022
20. The prognostic significance of left atrial appendage peak flow velocity in the recurrence of persistent atrial fibrillation following first radiofrequency catheter ablation
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Zhaoliang Shan, Qing Zhao, Yutang Wang, Wentao Yang, Yue Zhang, Minghui Yao, Chuanbin Liu, and Xiangdong Li
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Proportional hazards model ,medicine.medical_treatment ,Hazard ratio ,Atrial fibrillation ,medicine.disease ,Ablation ,Confidence interval ,Left atrial ,Interquartile range ,Internal medicine ,Cardiology ,Medicine ,Original Article ,business ,Survival rate - Abstract
BACKGROUND: Atrial fibrillation (AF) relapse following radiofrequency catheter ablation (RFCA) for persistent atrial fibrillation (PeAF) continues to be a concern. This study establishes a connection between left atrial appendage peak flow velocity (LAAV) and recurrence of AF in individuals having PeAF following first RFCA. METHODS: We retrospectively studied 164 successive PeAF patients who had first RFCA between January 2018 and December 2019. Before the ablation, the LAAV was recorded using transesophageal echocardiography (TEE). The demographic and clinical data of the individuals were gathered. Participants were monitored at regular intervals to monitor for recurrence of AF. We employed Cox proportional hazards regression to determine if LAAV, as well as other clinical indicators, were predictive of AF recurrence in follow-up. RESULTS: In this study, AF relapse was seen in 43 patients (26.2%) following a median follow-up of 15 [interquartile range (IQR): 12–18] months. It was shown that the LAAV was decreased in individuals who had recurrences of AF (0.36±0.05 vs. 0.45±0.17 m/s, P=0.004). Using Kaplan-Meier analysis, it was discovered that the low LAAV (0.37 m/s) group had a poorer event-free survival rate compared to the high LAAV (>0.37 m/s) group (17.6 vs. 21.2 months, log-rank P=0.002) group. Based on the results of the multivariate Cox regression analysis, a LAAV of fewer than 0.37 m/s [hazard ratio (HR): 2.32; 95% confidence interval (CI): 1.177–4.227; P=0.014] was shown to be an independent predictor of AF recurrence following RFCA. CONCLUSIONS: A low LAAV is associated with AF relapse, and it is a predictor of AF relapse following the first RFCA for PeAF. This discovery may be useful in the optimization of treatment strategies and the care of patients with PeAF.
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- 2021
21. Clinical effect of total thoracoscopic mitral valve surgery combined with atrial fibrillation radiofrequency ablation in patients with different left atrium diameter-a single center prospective observational cohort study
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Minghui Yao, Lin Zhang, Lianggang Li, Tong Ren, and Shengli Jiang
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Pulmonary and Respiratory Medicine - Abstract
Mitral valve surgery combined with atrial fibrillation (AF) radiofrequency ablation (AFRA) is recommended as the first-line strategy for valvular disease-related AF. There are relatively few reports on the effect of AFRA combined with total thoracoscopic mitral valve surgery. This article aimed to analyze the clinical data and prognostic outcomes of patients with diverse left atrium diameter (LAD) (50 or ≤50 mm) who underwent total thoracoscopic mitral valve surgery combined with AFRA.We conducted a prospective analysis of patients who underwent AFRA from January 2021 to June 2022 in the Department of Cardiovascular Surgery at the Chinese PLA General Hospital. The inclusion criteria were: (I) aged 40-70 years; (II) diagnosed with valvular heart disease and concomitant long-term persistent AF (1 year); (III) patients who underwent total thoracoscopic mitral valve surgery; (IV) with a left ventricular end-diastolic diameter of ≤70 mm; (V) with a LAD ≤65 mm; and (VI) left ventricular ejection fraction (LVEF) ≥50%. The included patients were assigned to group A and B depend up on the LAD. All patients were followed up at 3 and 6 months timepoints postoperatively. The prime endpoint was the recovery rate of sinus rhythm.There were 24 cases in group A (LAD50 mm) and 16 cases in group B (LAD ≤50 mm). The two groups exhibited no statistical differences in terms of age, gender proportion, preoperative comorbidities, AF duration, preoperative heart function, and type of valve disease (P0.05). The LAD, pulmonary artery pressure, and left ventricular diameter of group A were significantly greater than those of group B (P0.05). There were no new cerebrovascular incidents during the perioperative and follow-up periods. The sinus rhythm conversion rates in group A after surgery and at 6 months were 75% and 66.7%, respectively; meanwhile, both of these values were 87.5% in group B, and the difference between the groups was statistically significant (P0.05).Total thoracoscopic mitral valve surgery with AFRA is more effective in maintaining sinus rhythm in patients with LAD ≤50 mm than in those with LAD50 mm without increased risk of adverse events. Further studies are warranted to validate our findings.
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- 2022
22. Exploring the Molecular Mechanism of Zhi Bai Di Huang Wan in the Treatment of Systemic Lupus Erythematosus Based on Network Pharmacology and Molecular Docking Techniques
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Yanping Zhuang, Xuan Zhang, Simin Luo, Fangzhi Wei, Yitian Song, Guiling Lin, Minghui Yao, and Aimin Gong
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Process Chemistry and Technology ,Chemical Engineering (miscellaneous) ,Bioengineering ,Zhibai Dihuang Pill ,systemic lupus erythematosus ,network pharmacology ,molecular docking - Abstract
Objective: To investigate the molecular mechanism and simulated validation of Zhi Bai Di Huang Pill (ZBDHP) for the treatment of systemic lupus erythematosus (SLE) using network pharmacology and molecular docking techniques. Methods: The active ingredients of ZBDHP were obtained through the TCMSP database and the Canonical SMILES of the active ingredients were queried through Pubchem. The targets of the active ingredients were predicted in the SwissTarget database based on the SMILES. The SLE-related disease targets were obtained through the GeneCards, OMIM and DisGenets databases, and the intersection targets of ZBDHP and SLE were obtained using the Venny 2.1.0 online platform. Intersection targets build a visual protein interaction network (PPI) through the STRING database, and the core targets were identified by network topology analysis. GO analysis and KEGG pathway enrichment analysis of the intersecting targets were performed using the DAVID database. Finally, the molecular docking of the first four active ingredients and the first four core target genes were verified by Pubchem, the PDB database and CB-Dock online molecular docking technology. Results: ZBDHP screened 91 potential active ingredients and 816 potential targets. Among them, 141 genes were intersected by ZBDHP and SLE. The network topology analysis showed that the main active ingredients were Hydroxygenkwanin, Alisol B, asperglaucide, Cerevisterol, etc., and the key target genes were TNF, AKT1, EGFR, STAT3, etc. GO and KEGG enrichment analysis showed that common targets interfere with biological processes or molecular functions such as signal transduction protein phosphorylation, inflammatory response, transmembrane receptor protein tyrosine kinase activity, etc., through multiple signaling pathways, such as pathways in cancer, Kaposi sarcoma-associated herpesvirus infection, the PI3K-Akt signaling pathway, lipid and atherosclerosis, hepatitis B, etc. Molecular docking results showed that the active components of ZBDHP have good binding activity to the core targets of SLE. Conclusions: This study reveals that the ZBDHP treatment of SLE is a complex mechanistic process with multi-components, multi-targets and multi-pathways, and it may play a therapeutic role in SLE by inhibiting the production, proliferation and apoptosis of inflammatory factors. In conclusion, the present study provides a theoretical basis for further research on ZBDHP.
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- 2022
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23. Credit Risk Assessment Model of Commercial Banks Based on Fuzzy Neural Network.
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Ping Yao, Chong Wu, and Minghui Yao
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- 2009
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24. New Family of Combined Iterative Methods for Solving Nonlinear Equations.
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Shuping Chen, Fabao Gao, Wei Zhang 0084, and Minghui Yao
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- 2009
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25. Nonlinear coupling vibrations of graphene composite laminated sheets impacted by particles
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Bin Bai, Qiliang Wu, Dongxing Cao, Mingyuan Li, and Minghui Yao
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Partial differential equation ,Materials science ,Graphene ,Applied Mathematics ,Composite number ,02 engineering and technology ,Mechanics ,01 natural sciences ,Viscoelasticity ,law.invention ,Vibration ,Nonlinear system ,020303 mechanical engineering & transports ,0203 mechanical engineering ,law ,Modeling and Simulation ,0103 physical sciences ,Plate theory ,Particle ,010301 acoustics - Abstract
In this work, the graphene composite sheets coated with metal were equivalent to composite laminated sheets. The nonlinear coupling vibrations of graphene composite laminated sheets (GCLSs) under particle impact were investigated. The size-dependent effect and viscoelasticity were incorporated to model GCLSs in the nonlocal continuum theory and Kelvin-Voigt model framework. Particle impact was regarded as stochastic excitation on the GCLS. According to the von Karman strain-displacement relationship for the geometric nonlinearity and Reddy's third-order shear deformation plate theory, the nonlinear governing partial differential equations were derived. To examine the validity of this model, a comparison with published results was carried out. With the purpose of ensuring the convergence and reliability of the results, a large number of mode truncations were performed. The emphasis of numerical simulations was placed on studying how the various factors, including the size-dependent effect, forcing amplitude, and viscoelasticity, influencing the nonlinear responses of GCLS. The motivation of this study is to present a novel model providing both practical and theoretical guidance for devices involving graphene composites subjected to particle impacts.
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- 2021
26. Bifurcation and dynamic behavior analysis of a rotating cantilever plate in subsonic airflow
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Wei Zhang, Minghui Yao, Dongxing Cao, and Ma Li
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Physics ,Partial differential equation ,Cantilever ,Phase portrait ,Applied Mathematics ,Mechanical Engineering ,02 engineering and technology ,Mechanics ,01 natural sciences ,Physics::Fluid Dynamics ,Aerodynamic force ,Nonlinear system ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Mechanics of Materials ,Ordinary differential equation ,0103 physical sciences ,Galerkin method ,010301 acoustics ,Equations for a falling body - Abstract
Turbo-machineries, as key components, have a wide utilization in fields of civil, aerospace, and mechanical engineering. By calculating natural frequencies and dynamical deformations, we have explained the rationality of the series form for the aerodynamic force of the blade under the subsonic flow in our earlier studies. In this paper, the subsonic aerodynamic force obtained numerically is applied to the low pressure compressor blade with a low constant rotating speed. The blade is established as a pre-twist and presetting cantilever plate with a rectangular section under combined excitations, including the centrifugal force and the aerodynamic force. In view of the first-order shear deformation theory and von-Kármán nonlinear geometric relationship, the nonlinear partial differential dynamical equations for the warping cantilever blade are derived by Hamilton’s principle. The second-order ordinary differential equations are acquired by the Galerkin approach. With consideration of 1:3 internal resonance and 1/2 sub-harmonic resonance, the averaged equation is derived by the asymptotic perturbation methodology. Bifurcation diagrams, phase portraits, waveforms, and power spectrums are numerically obtained to analyze the effects of the first harmonic of the aerodynamic force on nonlinear dynamical responses of the structure.
- Published
- 2020
27. A potential treatment for COVID-19 based on modal characteristics and dynamic responses analysis of 2019-nCoV
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Hongbo Wang and Minghui Yao
- Subjects
Original Paper ,Coronavirus disease 2019 (COVID-19) ,Computer science ,Potential treatments ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Applied Mathematics ,Mechanical Engineering ,Spike Protein ,Aerospace Engineering ,Potential method ,Ocean Engineering ,Dynamic responses ,01 natural sciences ,Resonance (particle physics) ,Finite element method ,Modal ,Harmonic response ,Control theory ,Control and Systems Engineering ,Modal characteristics ,0103 physical sciences ,2019-nCoV ,Electrical and Electronic Engineering ,010301 acoustics - Abstract
The 2019-nCoV is ravaging the world, taking lots of lives, and it is emergent to find a solution to deal with this novel pneumonia. This paper provides a potential treatment for COVID-19 utilizing resonance to destroy the infection ability of 2019-nCoV. Firstly, the geometry size of 2019-nCoV is scaled up by 10,000 times. The additional mass is used to represent the effect of the fluid around a spike protein. The finite element analysis (FEA) is used to study the modal characteristics of the tuned 2019-nCoV model and mistuned 2019-nCoV model in blood, respectively. Based on FEA, the lumped parameter mechanical model of 2019-nCoV is established. Then, the dynamic responses of mistuned 2019-nCoV are investigated through harmonic response and dynamical analysis. Finally, a potential method utilizing 360° sweep excitation to cure COVID-19 is put forward.
- Published
- 2020
28. Design, Simulation and Experiment for a Vortex-Induced Vibration Energy Harvester for Low-Velocity Water Flow
- Author
-
Xiangying Guo, Minghui Yao, Xiangdong Ding, and Dongxing Cao
- Subjects
0209 industrial biotechnology ,Materials science ,Renewable Energy, Sustainability and the Environment ,Water flow ,Mechanical Engineering ,02 engineering and technology ,Mechanics ,021001 nanoscience & nanotechnology ,Industrial and Manufacturing Engineering ,Root mean square ,Vibration ,020901 industrial engineering & automation ,Flow velocity ,Vortex-induced vibration ,Management of Technology and Innovation ,General Materials Science ,0210 nano-technology ,Energy harvesting ,Beam (structure) ,Excitation - Abstract
Piezoelectric vibration energy harvesting has attracted considerable attention because of its prospects in self-powered electronic applications. There are a many low-velocity waters in nature, such as rivers, seas and oceans, which contain abundant hydrokinetic energy. In this paper, an optimal geometric piezoelectric beam combining magnetic excitation is identified and applied to a vortex-induced vibration energy harvester (ViVEH) for low velocity water flow, which is composed of a continuous variable-width piezoelectric beam carrying a cylindrical bluff body. The finite element simulation and experiment are first carried out to study the harvesting characteristics of the designed variable-width beam ViVEH without considering the magnetic excitation. The influence of the width-ratio and flow velocity on the harvesting voltage is studied in detail. The optimal structure, a ViVEH equipped with triangular piezoelectric beam, is then obtained by the superior energy harvesting performance for low velocity water flow. From the experimental results, at a flow velocity of 0.6 m/s, the highest root mean square (RMS) voltage and RMS voltage per unit area are 19.9 V and 0.07 V/mm2, respectively. Furthermore, magnetic excitation is introduced to improve the scavenging performance of the optimal triangular beam ViVEH, different polarity arrangements are compared, and the optimal case, the arrangement of horizontal repulsion and vertical attraction (HR-VA), is obtained. This case can scavenge the highest power of 173 μW at a flow velocity of 0.5 m/s, which is increased by 127% compared to a conventional constant-width beam ViVEH with no magnetic excitation.
- Published
- 2020
29. Effect of appeal orientation in sponsored ad forwarding on a microblog platform
- Author
-
Minghui Yao, Yunjie Calvin Xu, and Chenyan Gu
- Subjects
Economics and Econometrics ,Sociology and Political Science ,Computer science ,Random assignment ,Microblogging ,Communication ,Control (management) ,Appeal ,Advertising ,Social media ,Orientation (graph theory) ,Social commerce - Abstract
PurposeThis study identifies a new type of advertising, sponsored ad forwarding, in microblog contexts. It tests the effectiveness of designs of a message with an ad with regard to receivers who are purely online friends or offline friends.Design/methodology/approachIn the main experiment, a three-by-two experimental design was employed. By random assignment, message senders forwarded an ad with either an other-oriented or a self-oriented message to a group of offline friends or purely online friends. In the control group, there was no message accompanying the ad. The data of 218 effective sender-receiver dyads were collected and compared.FindingsThe results show that a message with an other-oriented appeal is more effective than one with a self-oriented appeal for dyads with an offline relationship, and a message with a self-oriented appeal is more effective than one with an other-oriented appeal for dyads with a purely online relationship. Overall, the use of appeals significantly boosts ad effectiveness.Originality/valueThis study identifies a new type of marketing practice in social media, namely sponsored ad forwarding. It also proposes appeal orientation as a novel type of message content design. It shows how to apply the right appeal orientation to the right receiver groups, that is, offline or purely online friends.
- Published
- 2020
30. A Novel Aerodynamic Force and Flutter of the High-Aspect-Ratio Cantilever Plate in Subsonic Flow
- Author
-
Ma Li, Minghui Yao, Dongxing Cao, Yan Niu, Wei Zhang, and Kai Lou
- Subjects
Airfoil ,Physics ,Cantilever ,Article Subject ,QC1-999 ,Mechanical Engineering ,02 engineering and technology ,Mechanics ,Geotechnical Engineering and Engineering Geology ,Condensed Matter Physics ,Critical value ,01 natural sciences ,010305 fluids & plasmas ,Physics::Fluid Dynamics ,Aerodynamic force ,Nonlinear system ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Mechanics of Materials ,0103 physical sciences ,Flutter ,Galerkin method ,Equations for a falling body ,Civil and Structural Engineering - Abstract
This paper focuses on the derivation of the aerodynamic force for the cantilever plate in subsonic flow. For the first time, a new analytical expression of the quasi-steady aerodynamic force related to the velocity and the deformation for the high-aspect-ratio cantilever plate in subsonic flow is derived by utilizing the subsonic thin airfoil theory and Kutta-Joukowski theory. Results show that aerodynamic force distribution obtained theoretically is consistent with that calculated by ANSYS FLUENT. Based on the first-order shear deformation and von Karman nonlinear geometric relationship, nonlinear partial differential dynamical equations of the high-aspect-ratio plate subjected to the aerodynamic force are established by using Hamilton’s principle. Galerkin approach is applied to discretize the governing equations to ordinary differential equations. Numerical simulation is utilized to investigate the relation between the critical flutter velocity and some parameters of the system. Results show that when the inflow velocity reaches the critical value, limit cycle oscillation occurs. The aspect ratio, the thickness, and the air damping have significant impact on the critical flutter velocity of the thin plate.
- Published
- 2020
31. Experimental study on broadband bistable energy harvester with L-shaped piezoelectric cantilever beam
- Author
-
Ma Li, Wei Zhang, Pengfei Liu, Hong-Bo Wang, and Minghui Yao
- Subjects
Materials science ,Bistability ,Phase portrait ,business.industry ,Mechanical Engineering ,Computational Mechanics ,Stiffness ,02 engineering and technology ,01 natural sciences ,Piezoelectricity ,Potential energy ,010305 fluids & plasmas ,Optics ,020401 chemical engineering ,0103 physical sciences ,medicine ,Physics::Accelerator Physics ,0204 chemical engineering ,medicine.symptom ,business ,Energy harvesting ,Beam (structure) ,Voltage - Abstract
This paper presents an experimental study of the broadband energy harvesting and dynamic responses of an L-shaped piezoelectric cantilever beam. Experimental results show that the L-shaped piezoelectric beam generates two optimal voltage peaks when the horizontal beam size is similar to the vertical beam size. Several optimized L-shaped piezoelectric cantilever beam structures are proposed. Power generation using the inverted bistable L-shaped beam is better. It is observed experimentally that the inverted bistable L-shaped beam structure shows obvious bistable characteristics and hard spring characteristics. Furthermore, the corresponding relationship between the bistable phase portrait and the potential energy curve is found in the experiment. This is the first time that a phase portrait for stiffness hardening of an L-shaped beam has been found experimentally. These results can be applied to analysis of new piezoelectric power generation structures.
- Published
- 2020
32. Nonlinear transient responses of rotating twisted FGM cylindrical panels
- Author
-
Minghui Yao, Yan Niu, and Wei Zhang
- Subjects
Backward differentiation formula ,Physics ,General Engineering ,Infinitesimal strain theory ,Equations of motion ,02 engineering and technology ,Mechanics ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Functionally graded material ,Mathematics::Numerical Analysis ,0104 chemical sciences ,Nonlinear system ,symbols.namesake ,symbols ,General Materials Science ,Hamilton's principle ,Transient (oscillation) ,0210 nano-technology ,Galerkin method - Abstract
This paper develops a new structure dynamic model to investigate nonlinear transient responses of the rotating blade made of functionally graded material (FGM). The rotating blade is simplified as a rotating FGM cylindrical panel with a presetting angle and a twist angle. The geometric nonlinearity effects are taken into account in the strain-displacement relationships, which are derived by Green strain tensor. Based on the first-order piston theory and the first-order shear deformation theory, the equations of motion for the rotating twisted FGM cylindrical panel are acquired by means of Hamilton principle and Galerkin method. Backward Differentiation Formula (BDF) and Runge-Kutta Algorithm are used to solve the nonlinear equations of motion for the system. The effects of four pulse load conditions on the system subjected to the internal pulse load or the external pulse load are fully discussed. A detailed parametric analysis is performed by considering the effects of the rotating speed, volume fraction index and temperature.
- Published
- 2020
33. Improved Flow-Induced Vibration Energy Harvester by Using Magnetic Force: An Experimental Study
- Author
-
Minghui Yao, Xiangdong Ding, Dongxing Cao, and Xiangying Guo
- Subjects
0209 industrial biotechnology ,Materials science ,Renewable Energy, Sustainability and the Environment ,Water flow ,Mechanical Engineering ,Acoustics ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Industrial and Manufacturing Engineering ,Sweep frequency response analysis ,Magnetic field ,Physics::Fluid Dynamics ,Vibration ,020901 industrial engineering & automation ,Flow velocity ,Vortex-induced vibration ,Management of Technology and Innovation ,Magnet ,General Materials Science ,0210 nano-technology ,Energy harvesting - Abstract
Vibration energy harvesting has attracted considerable attention because of its application prospects for charging or powering micro-electro-mechanical system. Abundant hydrokinetic energy of water at low velocity is contained in the fluid environment, such as rivers and oceans, which are widely existing in nature. In this paper, a flow-induced piezoelectric vibration energy harvester (PVEH) with magnetic force enhancement, which is integrated by piezoelectric beam, circular cylinder bluff body and magnets, is proposed and experimental investigated. It could transfer the hydrokinetic energy, both the vortex-induced vibration and magnetic force excitation underwater, into electricity. First, the frequency sweep experiment of the piezoelectric cantilever beam is carried out to determine the resonance frequency where the effect of magnetic force on the vibration characteristic is obtained. Furthermore, the flow-induced vibration experiment platform is setup and the energy harvesting performance of the PVEH is investigated in detail. The effects of the magnet property, flow velocity and the magnetic poles distance on the vibration frequency and the acquisition voltage are demonstrated and discussed. The results show that it could improve the harvesting performance by introducing magnetic force. It has advantages in higher output voltage for the flow-induced PVEH, especially in low velocity water flow, when the flow velocity is 0.35 m/s, the PVEH under attractive magnetic force with magnetic distance of 20 mm scavenges the higher acquisition voltage of 5.2 V, which is increased by 225% than the PVEH with non-magnetic. The results can be applied to guide further fabrication process and optimized design of the proposed flow-induced PVEH underwater with low flow velocity.
- Published
- 2020
34. Grand Challenges of Machine-Vision Technology in Civil Structural Health Monitoring
- Author
-
Lin Yunfan, Minghui Yao, Zou Xiangjun, Xueyu Huang, Tang Yunchao, and Huang Zhaofeng
- Subjects
Engineering management ,Engineering ,Machine vision ,business.industry ,Deep learning ,General Medicine ,Artificial intelligence ,Structural health monitoring ,business ,Civil infrastructure ,Condition assessment ,Grand Challenges ,Computer technology - Abstract
Machine-vision technology has progressed remarkably in both accuracy and speed owing to advances in computer technology and artificial intelligence. In this paper, state-of-the-art research on vision-based techniques is reviewed for civil infrastructure condition assessment. The major challenges of machine vision technique in civil structural health monitoring are presented.
- Published
- 2020
35. Integrated investigation on the nucleation and growing process of hydrate in W/O emulsion containing asphaltene
- Author
-
Yuanxing Ning, Minghui Yao, Yuxing Li, Guangchun Song, Zhiming Liu, Qingping Li, Haiyuan Yao, and Wuchang Wang
- Subjects
General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2023
36. Dynamic instability and internal resonance of rotating pretwisted composite airfoil blades
- Author
-
Yan Niu, Meiqi Wu, Minghui Yao, and Qiliang Wu
- Subjects
General Mathematics ,Applied Mathematics ,General Physics and Astronomy ,Statistical and Nonlinear Physics - Published
- 2022
37. Nonplanar free and forced vibrations of an imperfect nanobeam employing nonlocal strain gradient theory
- Author
-
Qiliang Wu, Minghui Yao, and Yan Niu
- Subjects
Numerical Analysis ,Applied Mathematics ,Modeling and Simulation - Published
- 2022
38. The Predictive Value of left atrial appendage peak flow velocity in Recurrence after initial radiofrequency catheter ablation of persistent atrial fibrillation: A single-center prospective study
- Author
-
Zhaoliang Shan, Wentao Yang, Qing Zhao, Yutang Wang, Yue Zhang, Xiangdong Li, Minghui Yao, and Chuanbin Liu
- Subjects
medicine.medical_specialty ,Proportional hazards model ,business.industry ,medicine.medical_treatment ,Atrial fibrillation ,medicine.disease ,Ablation ,Single Center ,Log-rank test ,Catheter ,Internal medicine ,Cardiology ,medicine ,business ,Prospective cohort study ,Survival rate - Abstract
Background: Recurrence after Radiofrequency catheter ablation(RFCA) of persistent atrial fibrillation (PeAF) is still elusive. The present study aimed to evaluate the relationship between the left atrial appendage peak flow velocity(LAAV) and atrial fibrillation(AF) recurrences in PeAF patients after their initial RFCA. Method: This study included 164 consecutive PeAF patients who performed initial RFCA from January 2018 to December 2019. Transesophageal echocardiography was used to collect the LAAV before ablation. Patients’ demographic and clinical information was gathered. To detect the recurrences of AF, patients were checked up at routine intervals. A Cox proportional hazards regression analysis was adopted to evaluate the LAAV and other clinical variables as predictors of AF recurrences throughout follow-up. Results: AF recurrence resulted in 43 (26.2%) patients after a median follow-up of 15 months (IQR: 12-18 months). LAAV reduced in patients with AF recurrences (0.36±0.15m/s vs. 0.45±0.17m/s, P = 0.004). A Kaplan-Meier study revealed that the low LAAV(≤0.37m/s) group had a lower event-free survival rate than the high LAAV (>0.37m/s) group (17.6 months vs. 21.2 months, Log Rank P = 0.002). LAAV≤0.37m/s (HR 2.32, 95%CI 1.177-4.227, P = 0.014) was found to be independent predictors of AF recurrence after RFCA in the multivariate Cox regression. Conclusion: A low LAAV is linked to AF recurrence and acts as a predictor of AF recurrence after the initial RFCA of peAF. This would aid in treatment strategy optimization and management of patients with peAF.
- Published
- 2021
39. Stability analysis for geometric nonlinear functionally graded sandwich shallow shell using a new developed displacement field
- Author
-
J. Chen, Minghui Yao, Z. Cao, Wen Zhang, and Y. X. Hao
- Subjects
Materials science ,Plane (geometry) ,Mathematical analysis ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Structural dynamics ,Displacement (vector) ,Transverse plane ,Nonlinear system ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Displacement field ,Ceramics and Composites ,0210 nano-technology ,Galerkin method ,Bifurcation ,Civil and Structural Engineering - Abstract
Although the stability of the sandwich structures under in-plane excitation has been reported, few of them focus on the functionally graded materials (FGM) sandwich doubly curved shallow shells. Moreover, for the study of static bifurcation, stability and dynamic stability analysis, it is common to ignore the effect of thickness tension or compression. The purpose of this paper is to explore the bifurcation and stability of the FGM sandwich doubly curved shallow shell which is subjected to the in-plane excitation in thermal environment . By introducing the secant function to the transverse displacement, a new displacement field based on the Reddy’s third order shear deformation theory is derived. It is assumed that the material properties of sandwich doubly curved shallow shell are temperature dependent. The distribution of component materials in FGM layer obeys the rule of power law in the radial direction . Considering the geometric nonlinear, using an energy approach and the Galerkin’s method, a two-degree-of-freedom non-autonomous nonlinear dynamic equation with parametric excitation is derived. The threshold of the bifurcation and the stability of the structure are investigated. The instability regions are plotted by dynamic load factor against excitation frequency in α 1 - Ω plane.
- Published
- 2019
40. Resonance in dangerous mode and chaotic dynamics of a rotating pre-twisted graphene reinforced composite blade with variable thickness
- Author
-
Yan Niu, Minghui Yao, and Qiliang Wu
- Subjects
Ceramics and Composites ,Civil and Structural Engineering - Published
- 2022
41. Dynamic analysis and design of power management circuit of the nonlinear electromagnetic energy harvesting device for the automobile suspension
- Author
-
Minghui Yao, Xinfang Wang, Qiliang Wu, Yan Niu, and Shaohong Wang
- Subjects
Control and Systems Engineering ,Mechanical Engineering ,Signal Processing ,Aerospace Engineering ,Computer Science Applications ,Civil and Structural Engineering - Published
- 2022
42. Free vibration of axially functionally graded beams using the asymptotic development method
- Author
-
Minghui Yao, Dongxing Cao, Yanhui Gao, and Wei Zhang
- Subjects
Physics ,Mathematical analysis ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Finite element method ,Vibration ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Boundary value problem ,Perturbation theory ,Invariant (mathematics) ,0210 nano-technology ,Axial symmetry ,Material properties ,Beam (structure) ,Civil and Structural Engineering - Abstract
Axially functionally graded (AFG) beams, with variable coefficients in the governing equation, are a novel class of composites structures that have continuous variations in material properties from one component to another. In this paper, the asymptotic development method (ADM) is utilized to investigate the free vibration of uniform AFG beams with different boundary conditions. By decomposing the variable flexural stiffness and mass per unit length into reference invariant parts and variant parts, perturbation theory is introduced to obtain an approximate formula of the natural frequencies of the uniform AFG beams. The numerical results of the proposed method are confirmed by comparing the obtained results with those obtained via finite element analysis and the published literature results, the comparison reveals the proposed method yields an accurate estimate of the first three order natural frequencies of the AFG beam. Moreover, the influences of the gradient parameter and support conditions on the first three natural frequencies are discussed. The proposed analytical method is simple and efficient and can be used to conveniently analyze uniform AFG beams with arbitrary changes in the material properties along the axial direction.
- Published
- 2018
43. Vibration reduction in truss core sandwich plate with internal nonlinear energy sink
- Author
-
J. Liu, Wei Zhang, M. Sun, Minghui Yao, and Jian-en Chen
- Subjects
Computer Science::Computer Science and Game Theory ,Frequency response ,Materials science ,Physics::Instrumentation and Detectors ,Computer Science::Neural and Evolutionary Computation ,Truss ,02 engineering and technology ,Mechanics ,Dissipation ,01 natural sciences ,Vibration ,Nonlinear system ,020303 mechanical engineering & transports ,Amplitude ,0203 mechanical engineering ,Excited state ,0103 physical sciences ,Ceramics and Composites ,010301 acoustics ,Excitation ,Civil and Structural Engineering - Abstract
The effects of an internal nonlinear energy sink (NES) on a truss core sandwich plate in dynamics are investigated. The energy dissipation of the NES is studied with the sandwich plate excited by a half-wave shock. It is found that exceptional vibration absorption is achieved by the NES. Moreover, the relative motion between the sandwich plate and the NES remains in the acceptable range of the hollow truss core until the shock amplitude becomes too large. The slow flow equation and the frequency response of the system are obtained by employing the complexification-averaging method. Although the NES exhibits excellent performance when the sandwich plate is under an excitation with a relatively small amplitude, the efficiency is gradually diminished with the emergence of a stable higher branch and the merging of higher and lower branches. During the entire process, the NES does not collide with the face sheet of the sandwich plate. Further, the variation of vibration absorption performance of the NES with the increase of strut radius is investigated. It is demonstrated that the variation of the strut radius has a greater influence on the vibration absorption with a harmonic load in comparison to absorption with a shock load .
- Published
- 2018
44. Analysis on global and chaotic dynamics of nonlinear wave equations for truss core sandwich plate
- Author
-
Wei Zhang, Earl H. Dowell, Minghui Yao, and Q. L. Wu
- Subjects
Physics ,Partial differential equation ,Applied Mathematics ,Mechanical Engineering ,Mathematical analysis ,Aerospace Engineering ,Ocean Engineering ,Torus ,Singular point of a curve ,01 natural sciences ,Stable manifold ,010305 fluids & plasmas ,Nonlinear system ,Control and Systems Engineering ,Slow manifold ,0103 physical sciences ,Heteroclinic orbit ,Homoclinic orbit ,Electrical and Electronic Engineering ,010301 acoustics - Abstract
This paper presents the study on the chaotic wave and chaotic dynamics of the nonlinear wave equations for a simply supported truss core sandwich plate combined with the transverse and in-plane excitations. Based on the governing equation of motion for the simply supported sandwich plate with truss core, the reductive perturbation method is used to simplify the partial differential equation. According to the exact solution of the unperturbed equation, two different kinds of the topological structures are derived, which one structure is the resonant torus and another structure is the heteroclinic orbit. The characteristic of the singular points in the neighborhood of the resonant torus for the nonlinear wave equation is investigated. It is found that there exists the homoclinic orbit on the unperturbed slow manifold. The saddle-focus type of the singular point appears when the homoclinic orbit is broken under the perturbation. Additionally, the saddle-focus type of the singular point occurs when the resonant torus on the fast manifold is broken under the perturbation. It is known that the dynamic characteristics are well consistent on the fast and slow manifolds under the condition of the perturbation. The Melnikov method, which is called the first measure, is applied to study the persistence of the heteroclinic orbit in the perturbed equation. The geometric analysis, which is named the second measure, is used to guarantee that the heteroclinic orbit on the fast manifold comes back to the stable manifold of the saddle on the slow manifold under the perturbation. The theoretical analysis suggests that there is the chaos for the Smale horseshoe sense in the truss core sandwich plate. Numerical simulations are performed to further verify the existence of the chaotic wave and chaotic motions in the nonlinear wave equation. The damping coefficient is considered as the controlling parameter to study the effect on the propagation property of the nonlinear wave in the sandwich plate with truss core. The numerical results confirm the validity of the theoretical study.
- Published
- 2018
45. Study on power generations and dynamic responses of the bistable straight beam and the bistable L-shaped beam
- Author
-
Minghui Yao, Wei Zhang, and Ma Li
- Subjects
Physics ,Bistability ,business.industry ,Quantitative Biology::Molecular Networks ,General Engineering ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Piezoelectricity ,Potential energy ,Power (physics) ,020303 mechanical engineering & transports ,Optics ,0203 mechanical engineering ,Magnet ,Physics::Accelerator Physics ,General Materials Science ,0210 nano-technology ,business ,Energy harvesting ,Beam (structure) ,Excitation - Abstract
In this paper, a simplified model of the bistable piezoelectric cantilever beam with magnets is established, and the potential energy of the bistable system is analyzed. We have proposed the bistable L-shaped beam structure, which has the same geometry dimensions of the bistable straight beam in the first time. The comparative study on power generations and dynamic responses of the bistable straight beam and the bistable L-shaped beam plays an important role in exploring excellent piezoelectric generator. The experiment structure includes the base layer and the piezoelectric layer. The harmonic excitation is given to the system. Theoretical analysis results show that the potential energy function of the system has two obvious steady potential wells. In addition, the depth of the upper potential well is different from that of the lower potential well when the gravity potential energy is considered. Experimental results demonstrate that the power generation for the straight beam is better than that of the horizontally placed L-shaped beam when the excitation amplitude is 450 mV. There is the existence that the energy harvesting capacity of the bistable L-shaped beam is better than that of the bistable straight beam when the excitation amplitude is 400 mV. Furthermore, the power generation of the bistable L-shaped beam with the upper potential well is obviously better than that of the bistable L-shaped beam with the lower potential well. In addition, comparing with the straight beam, the dynamic response of the bistable L-shaped beam is more complex when the external excitation frequency is changed. It is also observed that the distance between the magnets has the obvious influence on the dynamic response of the bistable system. It is very effective to select the appropriate distance between the magnets to improve the power generation of the bistable energy harvester under the fixed excitation conditions.
- Published
- 2018
46. Vibration of functionally graded sandwich doubly curved shells using improved shear deformation theory
- Author
-
S. B. Li, Minghui Yao, ZhenNi Li, Wei Zhang, and Y. X. Hao
- Subjects
Partial differential equation ,Materials science ,Computer simulation ,General Engineering ,Shell (structure) ,Harmonic (mathematics) ,Natural frequency ,02 engineering and technology ,Mechanics ,021001 nanoscience & nanotechnology ,Functionally graded material ,Vibration ,Nonlinear system ,020303 mechanical engineering & transports ,0203 mechanical engineering ,General Materials Science ,0210 nano-technology - Abstract
Nonlinear forced vibrations and natural frequency of sandwich functionally graded material doubly curved shallow shell with a rectangular base are investigated. The sandwich functionally graded material (FGM) doubly curved shell is subjected to a harmonic point load at centre. The sandwich doubly curved shell with homogeneous face sheets and FGM face sheets is considered respectively when the natural frequencies are studied. Reddy’s third order shear deformation theory is expanded in which stretching effects in thickness are considered by introducing the secant function. Hamilton’s principle and von-Karman type nonlinear geometric equation are applied to obtain partial differential equation of the FGM sandwich doubly curved shell. Comparative studies with other shear deformation theories are carried out to validate the present formulation. Navier method is used to discuss the natural vibration frequencies of the FGM sandwich doubly curved shell. Numerical simulation is applied to demonstrate the nonlinear dynamic responses of the FGM sandwich doubly curved shell. Multiple periods, quasi-period and chaos are detected for the dynamic system for different core thickness.
- Published
- 2018
47. Nonlinear Dynamics of the High-Speed Rotating Plate
- Author
-
Ma Li, Wei Zhang, and Minghui Yao
- Subjects
Physics ,Article Subject ,lcsh:Motor vehicles. Aeronautics. Astronautics ,media_common.quotation_subject ,Aerospace Engineering ,Equations of motion ,02 engineering and technology ,Mechanics ,Inertia ,01 natural sciences ,Physics::Fluid Dynamics ,Nonlinear system ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Composite plate ,Ordinary differential equation ,0103 physical sciences ,Supersonic speed ,lcsh:TL1-4050 ,Nonlinear Oscillations ,Galerkin method ,010301 acoustics ,media_common - Abstract
High speed rotating blades are crucial components of modern large aircraft engines. The rotating blades under working condition frequently suffer from the aerodynamic, elastic and inertia loads, which may lead to large amplitude nonlinear oscillations. This paper investigates nonlinear dynamic responses of the blade with varying rotating speed in supersonic airflow. The blade is simplified as a pre-twist and presetting cantilever composite plate. Warping effect of the rectangular cross-section of the plate is considered. Based on the first-order shear deformation theory and von-Karman nonlinear geometric relationship, nonlinear partial differential dynamic equations of motion for the plate are derived by using Hamilton’s principle. Galerkin approach is applied to discretize the partial differential governing equations of motion to ordinary differential equations. Asymptotic perturbation method is exploited to derive four-degree-of-freedom averaged equation for the case of 1 : 3 internal resonance-1/2 sub-harmonic resonance. Based on the averaged equation, numerical simulation is used to analyze the influence of the perturbation rotating speed on nonlinear dynamic responses of the blade. Bifurcation diagram, phase portraits, waveforms and power spectrum prove that periodic motion and chaotic motion exist in nonlinear vibration of the rotating cantilever composite plate.
- Published
- 2018
48. Method Bias Mechanisms and Procedural Remedies
- Author
-
Yunjie (Calvin) Xu and Minghui Yao
- Subjects
Survey methodology ,Sociology and Political Science ,Statistics ,Variance (accounting) ,Common-method variance ,Psychology ,Social Sciences (miscellaneous) - Abstract
As a crucial method in organizational and social behavior research, self-report surveys must manage method bias. Method biases are distorted scores in survey response, distorted variance in variables, and distorted relational estimates between variables caused by method designs. Studies on method bias have focused on post hoc statistical control, but integrated analyses of the sociopsychological mechanism of method bias are lacking. This review proposes a framework for method bias and offers a relatively complete and detailed review of the sociopsychological and statistical mechanisms of four main types of method bias and their procedural remedies. This review proposes “reduce, remove, and rectify” as a guideline for researchers in survey design to address method bias. Finally, this review presents two directions for future methodology research.
- Published
- 2021
49. Adaptive impedance matching for power management circuit for a piezoelectric energy harvester on the bridge
- Author
-
Yan Niu, Jia Li, and Minghui Yao
- Subjects
Cantilever ,Materials science ,business.industry ,Energy management ,Metals and Alloys ,Electrical engineering ,Impedance matching ,Condensed Matter Physics ,Equivalent impedance transforms ,Piezoelectricity ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Vibration ,Equivalent circuit ,Electrical and Electronic Engineering ,business ,Instrumentation ,Voltage - Abstract
A piezoelectric impact cantilever in the bridge and a self-powered low power management circuit with stable output voltage matched with a mechanical model are presented in this paper. Based on the piezoelectric effect, the low-frequency mechanical vibration is converted into high-frequency electrical signal oscillation. The generated voltage preserves into the low-power constant-voltage power management circuit, which can effectively store electric energy. The equivalent circuit model of vibration for a piezoelectric impact cantilever is obtained. The key of energy management circuit is to improve energy storage efficiency. When impedance matching is achieved, the efficiency is maximum. Since the equivalent impedance of piezoelectric material is different in the impact process and natural vibration process, this paper uses the delay link and D-trigger to form the peak detection circuit, which can distinguish two vibration processes. So different duty cycles are generated to control the buck-boost circuit to achieve adaptive impedance matching. It can be found that the efficiency reached more than 80 %. Compared with the traditional energy management circuit, the efficiency is increased by 18 %.
- Published
- 2021
50. Free vibration analysis of a pre-twisted sandwich blade with thermal barrier coatings layers
- Author
-
Dongxing Cao, Wei Zhang, Minghui Yao, and BingYi Liu
- Subjects
Engineering ,Cantilever ,Turbine blade ,business.industry ,Modal analysis ,General Engineering ,02 engineering and technology ,Structural engineering ,01 natural sciences ,law.invention ,Physics::Fluid Dynamics ,Vibration ,Thermal barrier coating ,020303 mechanical engineering & transports ,0203 mechanical engineering ,law ,0103 physical sciences ,Plate theory ,General Materials Science ,Composite material ,business ,Material properties ,010301 acoustics ,Campbell diagram - Abstract
A rotating cantilever sandwich-plate model with a pre-twisted and pre-set angle has been developed to investigate the vibrational behavior of an aero-engine turbine blade with thermal barrier coating (TBC) layers. The classic von Karman plate theory and the first-order shear deformation theory are applied to derive the energy equations of the rotating TBC blade, in which the geometric shapes, the work ambient temperature, and the TBC material properties are considered. The Chebyshev-Ritz method is used to obtain the nature frequency of the rotating TBC blade. For static frequency and modal analysis, the finite-element method (FEM) is also applied to compare and validate the results from the Chebyshev-Ritz method. A good agreement is found among these kinds of methods. For dynamic frequency, the results are analyzed in detail concerning the influence of system parameters such as the thickness of the TBC layer, the working temperature, and the pre-twisted and pre-set angle. Finally, the Campbell diagram is demonstrated to analyze the resonance property of the cantilever sandwich TBC blade model.
- Published
- 2017
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