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Based on the stimulus - organism - response theory, this paper analyzes the influence mechanism of museum website creativity on customer citizenship behavior. Through the empirical analysis of 268 questionnaires, the results show that the three dimensions of website creativity, aesthetics, novelty and ease of use, all have significant positive effects on flow experience; Aesthetic, novelty and ease of use have significant positive effects on customer recommendation behavior and customer feedback behavior. Flow experience has significant positive influence on customer recommendation behavior and customer feedback behavior. Flow experience plays a mediating role in the influence of aesthetics, novelty and ease of use on customer recommendation behavior and customer feedback behavior.

Based on the data of Chinese A-share pharmaceutical industry companies from 2017 to 2020, this paper analyzes the impact of ESG information disclosure on financial risk. The results show that good ESG information disclosure can significantly reduce the financial risk of enterprises. The effect of ESG information disclosure on financial risk control of non-state-owned enterprises is more prominent, and the higher the degree of marketization, the more obvious the positive effect.

The role of genetic factors in the occurrence and progression of CHB (CHB) is still not fully explored. In recent years, genome-wide association studies on CHB patients have demonstrated that a large number of CHB-associated single nucleotide polymorphisms exist in the gene intron, which may regulate expression at the transcriptional level. Modification of RNA m

This paper divides the creative class into cultural and technological creative class. After calculating the development trend of these two types of creative class agglomeration scale in 30 regions of China from 2009 to 2017, this paper uses fixed effect model to empirically analyze the impact of creative class agglomeration scale on the regional economy, and finally puts forward corresponding countermeasures. The results show that: first, on the one hand, from the perspective of evolution, the agglomeration scale of cultural and creative class in 14 regions has not changed, while the other 16 regions shows a development trend of first rising and then falling to the original level, and the agglomeration scale of technological and creative class in most regions has not changed; on the other hand, from the perspective of space, the agglomeration scale of cultural and technological creative class in most regions is always at a medium or low level, and in eastern region is relatively high while that in most western regions is relatively low. Secondly, the agglomeration of cultural and technological creative class has a significant positive impact on regional economic growth, while the latter has a greater impact, but it is not statistically significant.

Background and Aims: Emitasvir is a new type of hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor, and the data of phase 2 trial has shown emitasvir-sofosbuvir to have good safety and tolerance. We conducted this phase 3 trial to further verify the efficacy and safety. Methods: We evaluated the antiviral activity and safety of a 12-week regimen of emitasvir phosphate (100 mg) combined with sofosbuvir (400 mg) once daily in non-cirrhotic patients with genotype 1 HCV infection. The primary endpoint was a sustained virological response at 12 weeks (SVR12) after the end of treatment. Results: Of the 362 patients enrolled in the trial, 39.8% were male, 99.2% had HCV genotype 1b, 0.8% had genotype 1a and 79.8% were treatment-naïve. The average age was 47.2 years. All patients completed the treatment and follow-up. All 3 patients with genotype 1a achieved SVR. Two genotype 1b treatment-naïve patients experienced virologic relapse. The rate of SVR12 was 99.7% (358/359), and SVR24 was 99.4% (357/359) in genotype 1b. Overall, 36.2% had resistance-associated substitutions (RASs) in NS5A and 98.3% had RASs in NS5B at baseline. The RASs at baseline had no effect on the rates of response. Serious adverse events were reported in 16 patients and were not related to emitasvir-sofosbuvir. Most adverse events did not require therapy. Conclusions: The 12 weeks of treatment with emitasvir-sofosbuvir was a highly efficient and safe treatment for a wide range of patients with HCV genotype 1b infection without cirrhosis, who had not been treated or who had been treated with interferon-based regimen previously.

In plasma, miR-34a could be one of potential biomarkers for frailty and is involved in the physiology processes which are benefit from exercise. One of its targets, Smad4 play important role in TGF-β1 pathway which is a dominant factor for balancing collagen production and degradation in hepatic stellate cells. TGF-β1/Smad4 regulated collagen deposition is a hallmark of hepatic fibrosis. Thus, miR-34a could be a link between exercise and hepatic disease. The potential regulation on miR-34a by LncRNAs in hepatic stellate cells (HSCs) is still reserved to be revealed. In current study, it was hypothesized that a miR-34a interactor, lncRNA CCAT2 may regulate TGF-β1 pathway in liver fibrotic remodeling. Dual luciferase activity showed CCAT2 and Smad4 are targets of miR-34a-5p. Sh-CCAT2 transfection prohibit HSCs proliferation and induce HSCs apoptosis, also inhibited ECM protein synthesis in HSCs. Decreased miR-34a-5p enhanced HSCs proliferation, blocked HSCs apoptosis and promoted ECM protein production. miR-34a-5p inhibitor undo protective regulation of sh-CCAT2 in liver fibrosis. Furthermore, clinical investigation showed that CCAT2 and Smad4 expression level were significantly induced, while miR-34a-5p was significantly decreased in HBV related liver fibrosis serum. In conclusion, activated HSCs via TGF-β1/Smad4 signaling pathway was successfully alleviated by CCAT2 inhibition through miR-34a-5p elevation.

With the deterioration of our environment, it is imperative to develop high-performance photocatalysts for ‘green’ environmental protection. In this work, a novel TiO2/α′-AgVO3 heterostructure has been successfully synthesized by a straightforward hydrothermal method for the photodegradation of Rhodamine B (RhB). Specifically, TiO2/α′-AgVO3 with a molar ratio of 4:1 displays excellent stability and outstanding photodegradation efficiency, which can remove 94% RhB within 120 min visible light irradiation. The free radical capture experiments demonstrate that h+ and ·OH act as pivotal parts in the photodegradation of RhB. Additionally, the enhanced photocatalytic performance of TiO2/α′-AgVO3 heterostructure is mainly attributed to the appropriate surface areas, broadened range of light adsorption, more photocarrier generation, and effective charge separation. This research reveals that TiO2/α′-AgVO3 heterostructure is an efficient visible light photocatalyst and is expected to be applied in organic sewage degradation.

Based on the perspective of corporate culture,this study takes 464 A-share listed companies in China’s heavy pollution industries from 2015 to 2019 as samples.The panel regression model is used to explore the impact of green culture on corporate financial risk and the mediating role of environmental information disclosure.The results show that green culture can significantly reduce corporate financial risk,and environmental information disclosure has a partial mediation effect on the relationship between green culture and corporate financial risk.

Osteosarcoma is the second leading cause of cancer-associated mortality worldwide in children and adolescents. ZC3H12D has been shown to negatively regulate Toll-like receptor signaling and serves as a possible tumor suppressor gene. MicroRNAs (miRNAs/miRs) are known to play an important role in the proliferation of human osteosarcoma cells. However, whether miRNAs can affect tumor development by regulating the expression of ZC3H12D has not yet been investigated. The aim of the present study was to investigate the role of miR128-3p in regulating ZC3H12D expression, as well as its function in tumor cell proliferation, apoptosis, and metastasis. Reverse transcription-quantitative PCR, western blotting and dual luciferase reporter assays were performed to analyze the regulation of ZC3H12D expression by miR-128-3p. MTT, colony formation and flow cytometry assays were also used to analyze the effect of miR-128-3p on cell proliferation and apoptosis. A wound healing assay was performed to investigate the cell migration ability. The results demonstrated that miR-128-3p directly targeted ZC3H12D and downregulated its expression, thereby promoting cell proliferation and migration. miR-128-3p overexpression also improved resistance to cisplatin in MG-63 and 143B cell lines, supporting the hypothesis that miR-128-3p may function as an oncogene in osteosarcoma cells. The potential clinical significance of miR-128-3p as a biomarker and therapeutic target provides rationale for further investigation into the miR-128-3p-mediated molecular pathway and how it is associated with osteosarcoma development.

Hepatitis B virus-related liver cirrhosis (HBV-LC) is susceptible to bacterial infections, which could lead to adverse prognosis in patients. MicroRNAs (miRs/miRNAs) are easily detected in peripheral blood and are involved in multiple liver diseases. The present pilot study aimed to investigate differentially expressed (DE) miRNAs in the serum of patients with HBV-LC and bacterial infection, and to identify potential biomarkers. The first batch of clinical samples was collected, including four patients with HBV-LC and infection, four patients with HBV-LC without infection, four patients with chronic hepatitis B (CHB) and four healthy controls. miRNA expression was analyzed by Affymetrix GeneChip miRNA 4.0 Array. A total of 385 DE miRNAs (upregulated, 160; downregulated, 225) were detected in patients with HBV-LC and infection compared with patients with HBV-LC without infection. miR-4793-3p was significantly upregulated in patients with HBV-LC and infection compared with its levels in the other three groups: HBV-LC without infection [log-transformed fold change (logFC)=7.96; P=0.0458), CHB (logFC=34.53; P=0.0003) and healthy controls (logFC=3.34; P=0.0219)]. Reverse transcription-quantitative PCR (RT-qPCR) was performed to validate miR-4793-3p expression in another batch of clinical samples. RT-qPCR showed that miR-4793-3p was highly expressed in patients with HBV-LC and infection compared with its levels in patients with HBV-LC without infection (P

The transcription factor AP-2 β (TFAP2B) serves an important role in kidney development. MicroRNAs (miRNAs) regulate carcinogenic pathways and have gained increasing attention owing to their association with human clear cell renal cell carcinoma (ccRCC) tumorigenesis. However, whether miRNAs could affect renal cell tumorigenesis by regulating TFAP2B expression has not been identified. The aim of this study was to investigate the effects of miRNA on TFAP2B and its potential role in cell growth, invasion and migration. PCR, western blot and dual luciferase reporter assays were performed to analyze the effects of miR-142-5p on TFAP2B. Furthermore, MTT, flow cytometry, wound healing and Transwell migration assays were used to analyze the effect of miR-142-5p on cell proliferation and migration. The results demonstrated that miR-142-5p targeted TFAP2B and downregulated the expression of TFAP2B at the mRNA and protein levels, promoting cell proliferation and migration in two ccRCC cell lines, 786-O and A-498. This phenomenon supported the theory that miR-142-5p may function as an oncogene in ccRCC. The potential clinical significance of miR-142-5p as a biomarker and a therapeutic target provides rationale for further investigation into miR-142-5p-mediated molecular pathways and how these may be associated with ccRCC development.

Integrins are transmembrane glycoproteins expressed on the surface of various cells. They can conduct bidirectional signal transduction across cell membranes, exchange information between extracellular matrix proteins and intracellular molecules, and regulate cell adhesion and activation. During cancer development, integrins mediate crucial regulatory functions in anti-tumor response including tumor antigen uptake, activation of tumor-specific T cells, leukocyte trafficking into the tumor site and tumor cell killing. We provided a comprehensive overview of the structure of integrins, immune regulation, effects of integrins on tumor immunity and covered in vivo and in vitro studies of tissue culture, animal models of human diseases and gene knockout animals as well as the progress in clinical diagnosis and therapy of tumors.

There is growing concern about mitochondrial DNA (mtDNA) mutations with long-term NRTI exposure in HIV-1 infected children.Twenty-four HIV-1 infected children who started ART more than 2 years earlier who had an excellent virological response and had not changed their regimen were enrolled retrospectively. Their corresponding PBMCs in 2009 (T1), 2010 (T2) and 2013 (T3) were included. Sequencing of the entire mtDNA using next-generation sequencing revealed the spectrum of mtDNA variants.The trend showed that the number of mtDNA mutations during ART occurred as T1 T2 T3 (P = 0.086). Interestingly, the numbers of whole mtDNA mutations at T3 (median 41, range 24-62) were significantly greater than at T1 (34, 25-46, P = 0.029). A positive correlation was found between total mtDNA mutations and treatment time (r = 0.352, P = 0.002). During the observation period, mtDNA mutations more frequently occurred in the D-loop, cytochrome b (CYTB) and 12S rRNA regions. The heteroplasmic ratio of T3 was higher than that of T1 in CYTB and 12S rRNA (P = 0.034 and P = 0.042, respectively). High heteroplasmic population levels were found at nt 263 (A263G, D-loop) and nt 8860 (A8860G, ATPase6). A significant difference in heteroplasmy between T1, T2 and T3 occurred at nt 14783 (T14783C, CYTB, P = 0.048, T3 T2 T1).Our findings reveal the spectrum of mtDNA variants in HIV-1-infected children who had an excellent virological response. mtDNA mutations accumulated during ART may play an important role in facilitating the occurrence of mitochondrial dysfunction.

In Kushel and Tyaglov (2016) [10] , by making use of a connection between critical points and circulant matrices, the authors reproved, in an elegant manner, Schoenberg's conjecture, de Bruin and Sharma's conjecture. Some further questions and open problems are proposed in their paper. In this article, we provide answers to them.

Background Apoptosis-stimulating protein of p53-2 (ASPP2) is a damage-inducible P53-binding protein that enhances damage-induced apoptosis. Fibrosis is a wound-healing response, and hepatic stellate cells (HSCs) are key players in liver fibrogenesis. However, little is known about the relationship between ASPP2 and hepatic fibrosis. Aims We investigated the effects of ASPP2 overexpression in HSCs and the role of ASPP2 in mouse liver fibrogenesis. Methods Human HSCs (LX-2 cells) were pre-incubated with GFP adenovirus (Ad) or ASPP2 adenovirus (AdASPP2) for 24 h and then treated with or without TGF-β1. ASPP2+/− and ASPP2+/+ Balb/c mice were used to examine the effects of ASPP2 on liver fibrosis in vivo. ASPP2+/+ Balb/c mice were generated by injecting AdASPP2 into the tail vein of ASPP2 WT Balb/c mice; all mice received intraperitoneal injections of carbon tetrachloride. Results In this study, ASPP2 was found to markedly inhibit TGF-β1-induced fibrogenic activation of LX-2 cells. Further experiments using an autophagic flux assay confirmed that ASPP2 reduced the fibrogenic activation of LX-2 cells by inhibiting autophagy. Moreover, we found that ASPP2 overexpression attenuated the anti-apoptotic effects of TGF-β1 in LX-2 cells. The extent of liver fibrosis was markedly reduced in ASPP2+/+ mouse liver tissue compared with control mice; however, in ASPP2+/− mice, hepatic collagen deposition was significantly increased. Conclusion These results suggest that TGF-β1-induced autophagy is required for the fibrogenic response in LX-2 cells and that ASPP2 may both inhibit TGF-β1-induced autophagy and decrease liver fibrosis. Electronic supplementary material The online version of this article (doi:10.1007/s10620-017-4816-3) contains supplementary material, which is available to authorized users.

We prove a determinant inequality for block positive definite matrices which unifies a result of Thompson (1961) and a result of Fiedler and Markham (1994).

If a 2 × 2 block matrix [ A B B ⁎ C ] is positive semidefinite, where each block is square, then the following trace inequality holds | tr A C − tr B ⁎ B | ≤ tr A tr C − | tr B | 2 . This improves a result of Besenyei [2] . Moreover, we show that | tr B m | ≤ tr A m / 2 C m / 2 , m = 2 , 3 , … .

Im Zuge der Beschleunigung des Aufbaus und der Vervollstandigung des Sozialkreditsystems in China fuhren immer mehr Regionen innovative Mechanismen mit lokalen Besonderheiten zum Personal Credit Scoring ein. Mit Belohnungs- oder Bestrafungsmasnahmen gemas Credit Scores ist es ein Mittel der Sozialgovernance geworden. Als ein neues Governanceinstrument spielt Personal Credit Scoring eine wichtige Rolle in der Verbesserung von Zielgerichtetheit und Effektivitat der Sozialgovernance. In der Praxis entstehen allerdings Probleme wie eine zu breit angelegte Datenerfassung, eingeschrankte Transparenz der Bewertungsregeln sowie unklare Festlegung der Anwendungsbereiche. Vollstandige Umsetzung der Verfahrensanforderungen wahrend Etablierung und Durchfuhrung der Regeln zur Ermittlung der Credit Scores, Optimierung der Bewertungsdimensionen sowie Einschrankung des Verwendungsumfangs etc. sind einerseits unumganglich fur die Gewahrleistung der Rechtmasigkeit und Wirksamkeit des Personal Credit Scorings als neues Governanceinstrument und sind andererseits erforderlich zur Forderung der Rechtsstaatlichkeit sowie dem Aufbau einer Kreditgesellschaft.

Background and Aims: Ravidasvir (RDV) is a new generation pangenotypic hepatitis C virus (HCV) NS5A inhibitor, with high barrier to baseline resistance-associated species. This is the first phase 2/3 study conducted in Mainland China confirming the efficacy and safety of RDV + ritonavir-boosted danoprevir + ribavirin for 12 weeks in treatment-naïve noncirrhotic patients with genotype 1 infection in a large population. Methods: In this multicenter, randomized, double-blinded, placebo-controlled phase 2/3 trial (NCT03362814), we enrolled 424 treatment-naïve, noncirrhotic adult HCV genotype 1 patients. All patients were randomized at 3:1 ratio to receive a combination of RDV 200mg once daily plus ritonavir-boosted danoprevir 100mg/100mg twice daily and oral ribavirin 1000/1200mg/day (body weight

Let A, B be n × n positive definite matrices. Then for 0 ≤ t ≤ 1 ∏ i = k n λ i ( A ∘ B ) ≥ ∏ i = k n λ i ( ( A ♯ t B ) ( A ♯ 1 − t B ) ) ≥ ∏ i = k n λ i ( A B ) , k = 1 , … , n . This gives a weighted extension of a result of Ando [1] . The case where the eigenvalues λ i are replaced with the singular values σ i is also considered.

We first deny a conjecture raised in Xu et al. (2011) [14] and then we present some eigenvalue or singular value inequalities related to contractive matrices.

Fiedler and Markham (1994) proved $${\left( {\frac{{\det \hat H}}{k}} \right)^k} \geqslant \det H,$$ where H = (Hij)i,j=1n is a positive semidefinite matrix partitioned into n × n blocks with each block k × k and \(\hat H = \left( {tr{H_{ij}}} \right)_{i,j = 1}^n\) . We revisit this inequality mainly using some terminology from quantum information theory. Analogous results are included. For example, under the same condition, we prove $$\det \left( {{I_n} + \hat H} \right) \geqslant \det {\left( {{I_{nk}} + kH} \right)^{{1 \mathord{\left/ {\vphantom {1 k}} \right. \kern-\nulldelimiterspace} k}}}.$$

Let A be a density matrix in . Audenaert [J. Math. Phys. 48(2007) 083507] proved an inequality for Schatten p-norms:where Tr1 and Tr2 stand for the first and second partial trace, respectively. As an analogue of his result, we prove a determinantal inequality

We prove an inequality for the geometric mean of accretive operators,where the geometric mean was brought in by Drury [Linear Multilinear Algebra. 2015;63:296–301]. The proof makes use of a result of Mathias [SIAM J. Matrix Anal. Appl. 1992;13:640–654]. This inequality is then used to clarify several plausible assertions.

If $\begin{bmatrix}A & X \\ X^* & B\end{bmatrix}$ is positive semidefinite with each block $n\times n$, we prove that $$2s_j\Big(\Phi(X)\Big)\le s_j\Big(\Phi(A+B)\Big), \qquad j=1, \ldots, n,$$ where $\Phi: X\mapsto X+(\tr X)I$ and $s_j(\cdot)$ means the $j$-th largest singular value. This confirms a conjecture of the author in [Linear Algebra Appl. 459 (2014) 404-410].

Audenaert recently obtained some new matrix norm inequalities in Audenaert (2015) [2] , [3] . In this note, we provide alternative proofs for these results.

We confirm a conjecture in Wocjan and Elphick (2013) [4] about a lower bound of the chromatic number of a graph.

We point out several implications of a result of Djokovic (1971) [8] concerning orthogonality of normal matrices that satisfy a certain condition on the eigenvalues of their sum. We obtain an analogous result in the setting of conjugate-normal matrices.