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Abstract MXene materials have emerged as promising candidates for solving sustainable energy storage solutions due to their unique properties and versatility. MXene materials can not only be used directly as electrode materials but can also be used as functional materials to solve problems such as poor conductivity of electrode materials, severe volume expansion, dendrites, and dissolution of electrode materials. This perspective paper explores the potential applications of MXene materials for sustainable energy storage solutions, emphasizing their distinct characteristics and applications across various domains.

ABSTRACT Background Observational studies have suggested that obsessive–compulsive disorder (OCD) may be associated with Alzheimer's disease (AD). However, whether OCD is a causal risk factor for AD remains unclear. This study aimed to assess the causal effect of OCD on AD risk by performing a two‐sample Mendelian randomization (MR) analysis. Methods Genome‐wide association summary statistics were obtained for OCD, comprising 2688 cases and 7037 controls, as well as for AD, including 21,982 cases and 41,944 controls from Kunkle et al.’s study, and 39,918 cases and 358,140 controls from Wightman et al.’s study. On the basis of two diverse thresholds, OCD‐associated genetic variants were screened as instrumental variables (IVs) for subsequent MR analyses. Inverse variance weighed was the primary MR method. MR‐Egger, weighted median, and weighted mode were used as supplementary MR methods. Various sensitivity tests assessed the reliability of MR results. Results On the basis of strict IV selecting thresholds, inverse‐variance weighted (IVW) identified significant causal associations between genetic liability to OCD and increased risk of AD in two different sources ((i) Kunkle et al.: odds ratio [OR] = 1.070, 95% confidence interval [CI]: 1.015–1.127, p = 0.012; (ii) Wightman et al. 0.012; (iii) Wightman et al.: OR = 1.051, 95% CI: 1.014–1.090, p = 0.007). Three other supplementary MR methods yielded similar results to IVWs (OR > 1). Furthermore, all results were replicated in MR analyses based on lenient IV selecting thresholds. The sensitivity tests indicated that MR results were stable and not affected by significant horizontal pleiotropy. Conclusions This comprehensive MR study suggests that genetic liability to OCD is a causal risk factor for AD. Early intervention in patients with OCD may be beneficial in preventing future AD progression.

To realize large device density and high complexity in future on-chip microwave photonic system, a waveguide crossing with low loss, crosstalk and reflection is designed on the silicon nitride waveguide platform, which is compatible for on-chip microwave photonic processor. Furthermore, a multi-channel microwave photonic signal processing chip is fabricated based on the proposed waveguide crossings, and the performance of the chip is evaluated. In simulation, the proposed waveguide crossing maintains an insertion loss of ∼0.08 dB per crossing in the wavelength range of 1500 nm – 1600 nm, while the experiment result is 0.086 dB per crossing. As the wavelength changes, the measured variation of insertion loss per crossing is less than 0.02 dB. The crossings on the signal processing chip induce an extra insertion loss of 1.2 dB to each channel. Meanwhile, the measured crosstalk and reflection are both below −44 dB. Furthermore, the proposed waveguide crossing shows significant robustness for fabrication. With the advantages of ultra-low loss, crosstalk and reflection, the proposed waveguide crossing may support the establishment for future complicated on-chip microwave photonic systems.

Abstract Ingenious design and fabrication of advanced carbon‐based sulfur cathodes are extremely important to the development of high‐energy lithium‐sulfur batteries, which hold promise as the next‐generation power source. Herein, for the first time, we report a novel versatile hyphae‐mediated biological assembly technology to achieve scale production of hyphae carbon fibers (HCFs) derivatives, in which different components including carbon, metal compounds, and semiconductors can be homogeneously assembled with HCFs to form composite networks. The mechanism of biological adsorption assembly is also proposed. As a representative, reduced graphene oxides (rGOs) decorated with hollow carbon spheres (HCSs) successfully co‐assemble with HCFs to form HCSs@rGOs/HCFs hosts for sulfur cathodes. In this unique architecture, not only large accommodation space for sulfur but also restrained volume expansion and fast charge transport paths are realized. Meanwhile, multiscale physical barriers plus chemisorption sites are simultaneously established to anchor soluble lithium polysulfides. Accordingly, the designed HCSs@rGOs/HCFs‐S cathodes deliver a high capacity (1189 mA h g−1 at 0.1 C) and good high‐rate capability (686 mA h g−1 at 5 C). Our work provides a new approach for the preparation of high‐performance carbon‐based electrodes for energy storage devices.

Abstract Clustering ensemble (CE), renowned for its robust and potent consensus capability, has garnered significant attention from scholars in recent years and has achieved numerous noteworthy breakthroughs. Nevertheless, three key issues persist: (1) the majority of CE selection strategies rely on preset parameters or empirical knowledge as a premise, lacking adaptive selectivity; (2) the construction of co-association matrix is excessively one-sided; (3) the CE method lacks a more macro perspective to reconcile the conflicts among different consensus results. To address these aforementioned problems, a dual-level clustering ensemble algorithm with three consensus strategies is proposed. Firstly, a backward clustering ensemble selection framework is devised, and its built-in selection strategy can adaptively eliminate redundant members. Then, at the base clustering consensus level, taking into account the interplay between actual spatial location information and the co-occurrence frequency, two modified relation matrices are reconstructed, resulting in the development of two consensus methods with different modes. Additionally, at the CE consensus level with a broader perspective, an adjustable Dempster–Shafer evidence theory is developed as the third consensus method in present algorithm to dynamically fuse multiple ensemble results. Experimental results demonstrate that compared to seven other state-of-the-art and typical CE algorithms, the proposed algorithm exhibits exceptional consensus ability and robustness.

Metal-ion (Li-, Na-, Zn-, K-, Mg-, and Al-ion) batteries (MIBs) play an important role in realizing the goals of “emission peak and carbon neutralization” because of their green production techniques, lower pollution, high voltage, and large energy density. Carbon-based materials are indispensable for developing MIBs and are widely adopted as active or auxiliary materials in the anodes and cathodes. For example, carbon-based materials, including graphite, Si/C and hard carbon, have been used as anode materials for Li- and Na-ion batteries. Carbon can also be used as a conductive coating for cathodes, such as in LiFePO4/C, to achieve better performance. In addition, as new high-valence MIBs (Zn-, Al-, and Mg-ion) have emerged, a growing number of novel carbon-based materials have been utilized to construct high-performance MIBs. Herein, we discuss the recent development trends in advanced carbon-based materials for MIBs. The impact of the structure properties of advanced carbon-based materials on energy storage is addressed, and a perspective on their development is also proposed.

In this work, a hybrid integrated tunable external cavity laser (ECL) with a sub-10 Hz intrinsic linewidth is demonstrated. In this hybrid ECL, two Si3N4-based subwavelength hole defect assisted microring resonators, acting as high-Q laser reflectors, are butt-coupled with a chip-scale semiconductor optical amplifier at the two edges, respectively. The experimental results show that the hybrid ECL achieves a sub-10 Hz intrinsic linewidth across a wavelength tuning range from 1525 to 1565 nm, featuring a record lowest value of 6.06 Hz. The demonstrated hybrid ECL opens up opportunities toward the applications of high-speed optical communications and high-resolution light detection and ranging.

Exploiting novel materials with high specific capacities is crucial for the progress of advanced energy storage devices. Intentionally constructing functional heterostructures based on a variety of two-dimensional (2D) substances proves to be an extremely efficient method for capitalizing on the shared benefits of these materials. By elaborately designing the structure, a greatly escalated steadiness can be achieved throughout electrochemical cycles, along with boosted electron transfer kinetics. In this study, chemical vapor deposition (CVD) was utilized to alter the surface composition of multilayer Ti3C2Tx MXene, contributing to contriving various layered heterostructure materials through a precise adjustment of the reaction temperature. The optimal composite materials at a reaction temperature of 500 °C (defined as MX500), incorporating MXene as the conductive substrate, exhibited outstanding stability and high coulombic efficiency during electrochemical cycling. Meanwhile, the reactive sites are increased by using TiS2 and TiO2 at the heterogeneous interfaces, which sustains a specific capacity of 449 mAh g−1 after 200 cycles at a current density of 0.1 A g−1 and further demonstrates their exceptional electrochemical characteristics. Additionally, the noted pseudocapacitive properties, like MXene materials, further highlight the diverse capabilities of intuitive material design. This study illuminates the complex details of surface modification in multilayer MXene and offers a crucial understanding of the strategic creation of heterostructures, significantly impacting sophisticated electrochemical applications.

Cancer stem cells (CSCs) are closely associated with tumor initiation, metastasis, chemoresistance, and recurrence, which represent some of the primary obstacles to cancer treatment. Targeting CSCs has become an important therapeutic approach to cancer care. Secoemestrin C (Sec C) is a natural compound with strong anti-tumor activity and low toxicity. Here, we report that Sec C effectively inhibited colorectal CSCs and non-CSCs concurrently, mainly by inhibiting proliferation, self-renewal, metastasis, and drug resistance. Mechanistically, RNA-seq analysis showed that the pro-inflammation pathway of the IL17 axis was enriched, and its effector S100A8 was dramatically decreased in Sec C-treated cells, whose roles in the stemness of CSCs have not been fully clarified. We found that the overexpression of S100A8 hindered the anti-CSCs effect of Sec C, and S100A8 deficiency attenuated the stemness traits of CSCs to enhance the Sec C killing activity on them. Meanwhile, the p38 signal pathway, belonging to the IL17 downstream axis, can also mediate CSCs and counter with Sec C. Notably, we found that S100A8 upregulation increased the p38 protein level, and p38, in turn, promoted S100A8 expression. This indicated that p38 may have a mutual feedback loop with S100A8. Our study discovered that Sec C was a powerful anti-colorectal CSC agent, and that the positive feedback loop of p38–S100A8 mediated Sec C activity. This showed that Sec C could act as a promising clinical candidate in colorectal cancer treatment, and S100A8 could be a prospective drug target.

Vanadium dioxide, as one of superior pseudocapacitive electrode candidates in supercapacitors, suffers from the detrimental dissolution in aqueous electrolytes and poor intrinsic electronic conductivity. Herein, an ultrathin Ni3N shell is deposited on the VO2 surfaces (VO2@Ni3N) to inhibit the inevitable dissolution during charge/discharge processes. Meanwhile, the Ni3N coating layer also provides sufficient electron transport pathways for the rapid surface faradic reactions of VO2, promoting the electrochemical reaction kinetics. The designed VO2@Ni3N anode exhibits significant energy storage ability, especially at large current density (2058 F g−1 at 1 A g−1, 711 F g−1 at 7 A g−1), and the considerable cycling lifespans (capacitance retention of 91.3% after 5000 cycles). The asymmetric supercapacitor presents an energy density of 41.73 Wh kg−1 at a power density of 1176.7 W kg−1. This study may enlighten the design of advanced pseudocapacitive materials for practical electrochemical energy storage technologies.

Abstract There are only six isolated living giant panda populations, and a comprehensive understanding of their genetic health status is crucial for the conservation of this vulnerable species. Liangshan Mountains is one of the main distribution areas of living giant pandas and is outside the newly established Giant panda national park. In this study, 971 giant panda fecal samples were collected in the heartland of Liangshan Mountains (Mabian Dafengding Nature Reserve: MB; Meigu Dafengding Nature Reserve: MG; and Heizhugou Nature Reserve: HZG). Microsatellite markers and mitochondrial D‐loop sequences were used to estimate population size and genetic diversity. We identified 92 individuals (MB: 27, MG: 22, HZG: 43) from the three reserves. Our results showed that: (1) genetic diversity of three giant panda populations was moderate; (2) several loci deviated significantly from the Hardy–Weinberg equilibrium and almost all these deviated loci showed significant heterozygote deficiencies and inbreeding; (3) three giant panda populations have substantial genetic differentiation with the most differentiation between MB and the two other populations; and (4) a large amount of giant panda feces outside the three reserves were found, implying the existence of protection gap. These results indicated that under stochastic events, the giant panda populations in Liangshan Mountains are at risk of genetic decline or extinction and urgent need of human management. This study revealed that high attention should be paid to the protection of these giant panda populations outside the Giant panda national park, to ensure their survival in their distribution areas.

To meet the requirement of radio frequency signal processing tasks among various frequency bands, here we have demonstrated a reconfigurable microwave photonic bandpass filter by flipping the optical notch spectrum of a cascaded microring resonator (MRR) filter pool chip through phase modulation. We experimentally characterize the cascaded MRR filter pool chip on the Si3N4 platform and evaluate the system performance of the established microwave photonic filter (MPF). In the demonstrated microwave photonic filter system, the center frequency can be tuned within 5.8--18.2 GHz and the bandwidth can be tuned within 2.1--3.5 GHz. In particular, the MPF system features a response with a shape factor of ∼2.2. With the advantages of reconfigurability and good shape factor, the demonstrated reconfigurable RF bandpass filter shows a potential application in future software-defined RF frontends.

Integrating diffractive optical neural networks (DONN) would reduce errors due to bulky components and calibration. Here, the authors exploit integrated 1D dielectric metasurfaces to realise an on-chip DONN device with 90% classification accuracy, computing at 10^16 flops/mm^2 and consuming 10E-17 J/Flop.

Abstract Background Increasing evidence has suggested an association between carotid atherosclerosis (CAS) and periodontitis (PD); however, the mechanisms have not been fully understood. This study aims to investigate the shared genes and molecular mechanisms underlying the co-pathogenesis of CAS and PD. Methods Gene Expression Omnibus (GEO) datasets GSE100927 and GSE10334 were downloaded, and differentially expressed genes (DEGs) shared by both datasets were identified. The functional enrichment analysis of these overlapping DEGs was then conducted. A protein-protein interaction (PPI) network was created using the STRING database and Cytoscape software, and PPI key genes were identified using the cytoHubba plugin. Then, weighted gene co-expression network analysis (WGCNA) was performed on GSE100927 and GSE10334, and the gene modules most correlated with CAS and PD were identified as key modules. The genes in key modules overlapping with PPI key genes were determined to be the key crosstalk genes. Subsequently, the key crosstalk genes were validated in three independent external datasets (GSE43292 [CAS microarray dataset], GSE16134 [PD microarray dataset], and GSE28829 [CAS microarray dataset]). In addition, the immune cell patterns of PD and CAS were evaluated by single-sample gene set enrichment analysis (ssGSEA), and the correlation of key crosstalk genes with each immune cell was calculated. Finally, we investigated the transcription factors (TFs) that regulate key crosstalk genes using NetworkAnalyst 3.0 platform. Results 355 overlapping DEGs of CAS and PD were identified. Functional enrichment analysis highlighted the vital role of immune and inflammatory pathways in CAS and PD. The PPI network was constructed, and eight PPI key genes were identified by cytoHubba, including CD4, FCGR2A, IL1B, ITGAM, ITGAX, LCK, PTPRC, and TNF. By WGCNA, the turquoise module was identified as the most correlated module with CAS, and the blue module was identified as the most correlated module with PD. Ultimately, ITGAM and LCK were identified as key crosstalk genes as they appeared both in key modules and PPI key genes. Expression levels of ITGAM and LCK were significantly elevated in the case groups of the test datasets (GSE100927 and GSE10334) and validation datasets (GSE43292, GSE16134, and GSE28829). In addition, the expression of multiple immune cells was significantly elevated in PD and CAS compared to controls, and the two key crosstalk genes were both significantly associated with CD4 T cells. Finally, SPI1 was identified as a potential key TF, which regulates the two key crosstalk genes. Conclusion This study identified the key crosstalk genes and TF in PD and CAS, which provides new insights for further studies on the co-morbidity mechanisms of CAS and PD from an immune and inflammatory perspective.

This work highly decreases the size, power, and computation for machine vision with novel joint-optimized opto-electronic neural networks.

Abstract Lithium‐sulfur batteries (Li‐S batteries) have been regarded as one of the most promising technologies to change the status quo of lithium‐ion battery and realize large‐scale energy storage applications. Nevertheless, the process of launching Li‐S batteries from lab to market is seriously hindered by their inherent shortages (for example, shuttled lithium polysulfides (LiPSs), and sluggish redox kinetics), which greatly restrict sulfur utilization and the battery cycle life. In this regard, Co‐based materials are effective to suppress the shuttle effect through anchoring soluble LiPSs and enhancing reaction kinetics. It is of great significance for the development of advanced catalytic materials to clarify the research progress of Co‐based materials in design strategy, modification mechanism and electrochemical properties. Considering this, we conduct a comprehensive review of recent progress with Co‐based materials utilized in Li‐S batteries. Specifically, the state‐of‐the‐art principles, challenges, and build strategies of Li‐S batteries are systematically summarized. Meanwhile, the chemical and catalytic interactions between the Co‐based materials and LiPSs, as well as energy storage performance of Co‐based materials are thoroughly discussed. Finally, we prospect the future opportunities and challenges for the practical application for advanced Li‐S batteries.

Pancreatic adenocarcinoma (PAAD) is one of the most lethal malignancies. Although gemcitabine (GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C (Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect (80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-l-cysteine (NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum (ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation (ERAD) ubiquitinates and downregulates YAP to enhance ER stress via destruction complex (YAP–Axin–GSK–βTrCP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate.

A hybrid integrated gain-switched (GS) optical frequency comb (OFC) source with eight pure continuous comb lines within 3-dB of the spectral envelope peak and a narrow linewidth of 615 kHz is proposed and demonstrated by coupling a silicon nitride microring reflector (MRR) to a commercially available distributed feedback (DFB) laser. Due to the self-injection locking effect induced by the MRR, the carrier-to-noise ratio (CNR) and phase correlation between comb lines are greatly enhanced. In addition, benefiting from the unique merit of gain switching, the resultant comb can also achieve a large frequency spacing adjustment range from 5.55 GHz to 8.7 GHz. This work explores a cost-efficient and robust OFC source for numerous applications, such as radio over fiber (RoF) and coherent optical communication.

Background: Previous studies have suggested that dexmedetomidine may have a protective effect on renal function. However, it is currently unclear whether perioperative dexmedetomidine administration is associated with postoperative acute kidney injury (AKI) incidence risk in hypertensive patients undergoing non-cardiac surgery.Methods: This investigation was a retrospective cohort study. Hypertensive patients undergoing non-cardiac surgery in Third Xiangya Hospital of Central South University from June 2018 to December 2019 were included. The relevant data were extracted through electronic cases. The univariable analysis identified demographic, preoperative laboratory, and intraoperative factors associated with acute kidney injury. Multivariable stepwise logistic regression was used to assess the association between perioperative dexmedetomidine administration and postoperative acute kidney injury after adjusting for interference factors. In addition, we further performed sensitivity analyses in four subgroups to further validate the robustness of the results.Results: A total of 5769 patients were included in this study, with a 7.66% incidence of postoperative acute kidney injury. The incidence of postoperative acute kidney injury was lower in the dexmedetomidine-administered group than in the control group (4.12% vs. 8.06%, p < 0.001). In the multivariable stepwise logistic regression analysis, perioperative dexmedetomidine administration significantly reduced the risk of postoperative acute kidney injury after adjusting for interference factors [odds ratio (OR) = 0.56, 95% confidence interval (CI): 0.36–0.87, p = 0.010]. In addition, sensitivity analysis in four subgroups indicated parallel findings: i) eGRF

Three new hexadepsipeptides (1–3), along with beauvericin (4), beauvericin D (5), and four 4-hydroxy-2-pyridone derivatives (6–9) were isolated from the endophytic fungus Fusarium sp. CPCC 400857 that derived from the stem of tea plant. Their structures were determined by extensive 1D and 2D NMR, and HRESIMS analyses. The absolute configuration of hexadepsipeptides were elucidated by the advanced Marfey’s method and chiral HPLC analysis. Compounds 4, and 7–9 displayed the cytotoxicity against human pancreatic cancer cell line, AsPC-1 with IC50 values ranging from 3.45 to 29.69 μM, and 7 and 8 also showed the antiviral activity against the coronavirus (HCoV-OC43) with IC50 values of 13.33 and 6.65 μM, respectively.

The framework provides a novel pipeline for action recognition. The action recognition task classifies the action label of the scene. High-speed cameras are commonly used to generate high frame-rate videos for capturing sufficient motion information. However, the data volume would be the bottleneck of the system. With the insight that the discrete cosine transform (DCT) of video signals reveals the motion information remarkably, instead of obtaining video data as with traditional cameras, the proposed method directly captures a DCT spectrum of video in a single shot through optical pixel-wise encoding. Considering that video signals are sparsely distributed in the DCT domain, a learning-based frequency selector is designed for pruning the trivial frequency channels of the spectrum. An opto-electronic neural network is designed for action recognition from a single coded spectrum. The optical encoder generates the DCT spectrum, and the rest of the network jointly optimizes the frequency selector and classification model simultaneously. Compared to conventional video-based action recognition methods, the proposed method achieves higher accuracy with less data, less communication bandwidth, and less computational burden. Both simulations and experiments demonstrate that the proposed method has superior action recognition performance. To the best of our knowledge, this is the first work investigating action recognition in the DCT domain.

An important tool for conserving species and their habitats and achieving sustainable development is the establishment of national parks. The population ecology of the species to be conserved, including their population size and suitable habitat, needs to be assessed prior to integrating protected areas into national parks. The Liangshan Mountains are currently the southernmost habitat of giant pandas and lie outside the newly established Giant Panda National Park (GPNP). The population is threatened with extinction due to severe isolation and human disturbance. However, there has been a ten-year gap in the census of giant pandas in this critical area. This means that conservation managers are unable to keep up to date with population and habitat dynamics. The Meigu Dafengding National Nature Reserve is the core area of the giant panda population in Liangshan and the link for gene exchange. The focus of this study is to assess the spatial distribution pattern of suitable habitat, habitat fragmentation and the habitat selection characteristics of giant pandas in the Meigu Dafengding Nature Reserve in Liangshan in order to lay the foundation for the future inclusion of Liangshan into the national park. A total of 151 giant panda fecal samples were collected in 2023. Using the distance–bamboo stem fragments method, this indicated that nearly 28 to 29 giant pandas exist within the reserve. Based on MaxEnt and FRAGSTATS, the giant panda population is concentrated in Wahei–Yiziyakou. They tend to choose gentle slopes of 10–30°, at altitudes between 2500 m and 3500 m, with average annual temperatures between 8.5 °C and 10 °C. They also select the areas close to roads and settlements for their frequent activities. Unsuitable habitat is widespread and surrounds low-, medium- and high-suitability habitats with poor habitat connectivity. In situ conservation measures are urgently needed due to the restricted distribution of populations and poor habitat suitability. This lays the foundation for the future inclusion of Liangshan into the national park, providing greater protection for the giant panda and other species in the region, and for other national parks to integrate all habitats into a single management unit. This will address conservation gaps and overlapping management, and promote the conservation of rare or endangered species.

The giant panda (Ailuropoda melanoleuca) is a special rare and endangered species in China and is the flagship species for global biodiversity conservation. This study used different methods including Kernel density, statistical analysis, and logistic regression analysis to investigated the spatial distribution, migration in different seasons and different distribution areas, as well as the foraging patch selection strategies of wild giant pandas in Meigu Dafengding National Nature Reserve in the Liangshan Mountains. The results demonstrated that, in the study area, giant pandas were mainly distributed in the Wahei-Yizi Yakou Habitat Corridor with an activity area of 144.93 km2, which accounted for 28.59% of the whole reserve. The core distribution area of the species was 92.07 km2 and the population density was 0.24 pcs km–2. There were two significant seasonal domains for the activities of giant pandas: the low-altitude winter habitat of Yushania maculata Yi and Yushania ailuropodina Yi bamboo species, as well as the high-altitude summer habitat of Bashania fangiana species. With seasonal changes, giant pandas migrated among different bamboo distribution regions. Giant pandas were mainly distributed in high-altitude areas that had secondary forest, tall trees with a large diameter at breast height (DBH) and bamboo forest. The spatial distribution pattern and microhabitat selection of giant pandas in Meigu Dafengding National Nature Reserve were determined. The findings of this study provide scientific implications for the local conservation and management of the habitat of wild giant pandas.

Background: Dexmedetomidine is a commonly used clinical sedative; however, the drug response varies among individuals. Thus, the purpose of this study was to explore the association between dexmedetomidine response and gene polymorphisms related to drug-metabolizing enzymes and drug response (CYP2A6, UGT2B10, UGT1A4, ADRA2A, ADRA2B, ADRA2C, GABRA1, GABRB2, and GLRA1).Methods: This study was a prospective cohort study. A total of 194 female patients aged 18–60 years, American Society of Anesthesiologists (ASA) score I-II, who underwent laparoscopy at the Third Xiangya Hospital of Central South University, were included. The sedative effect was assessed every 2 min using the Ramsay score, and the patient’s heart rate decrease within 20 min was recorded. Peripheral blood was collected from each participant to identify genetic variants in the candidate genes of metabolic and drug effects using the Sequenom MassARRAY® platform. Furthermore, additional peripheral blood samples were collected from the first 99 participants at multiple time points after dexmedetomidine infusion to perform dexmedetomidine pharmacokinetic analysis by Phoenix® WinNonlin 7.0 software.Results: Carriers of the minor allele (C) of CYP2A6 rs28399433 had lower metabolic enzyme efficiency and higher plasma concentrations of dexmedetomidine. In addition, the participants were divided into dexmedetomidine sensitive or dexmedetomidine tolerant groups based on whether they had a Ramsay score of at least four within 20 min, and CYP2A6 rs28399433 was identified to have a significant influence on the dexmedetomidine sedation sensitivity by logistic regression with Plink software [p = 0.003, OR (95% CI): 0.27 (0.11–0.65)]. C allele carriers were more sensitive to the sedative effects of dexmedetomidine than A allele carriers. GABRA2 rs279847 polymorphism was significantly associated with the degree of the heart rate decrease. In particular, individuals with the GG genotype had a 4-fold higher risk of heart rate abnormality than carriers of the T allele (OR = 4.32, 95% CI: 1.96–9.50, p = 0.00027).Conclusion:CYP2A6 rs28399433 polymorphism affects the metabolic rate of dexmedetomidine and is associated with susceptibility to the sedative effects of dexmedetomidine; GABRA2 rs279847 polymorphism is significantly associated with the degree of the heart rate decrease.

Gel polymer-ceramic hybrid electrolytes (GHEs) have emerged as desirable candidates for preparing high energy density and excellent practicability gel batteries. However, the agglomeration of ceramic particles in polymer matrix leads to a decrease in cycling stability and low mechanical properties of GHEs. Here, we present a feasible method for improving the dispersity of Li0.24La0.59TiO3 (LLTO) nanorods in the polyvinylidenefluoride (PVDF)/poly(propylene carbonate) (PPC) co-blended matrix (K–LLTO/PVDF/PPC) by γ-(2,3-epoxypropoxy)propytrimethoxysilane (KH560) surface treatment. The as-prepared GHE with 10% K–LLTO filler (10% GHE) exhibits a high ionic conductivity (3.01 mS cm−1) and an appropriate lithium-ion transference number (0.55). The Li|10% GHE|Li symmetric cell shows an exceptional lithium stripping-plating lifetime of > 2000 h at 0.1 mA cm−2. The assembled LiFePO4 (LFP)|10% GHE|Li full cells show satisfactory cycling stability in the 2.5–4.2 V electrochemical window by recovering 84% of the initial capacity at 2 C over 500 cycles. The uniformly dispersed K–LLTO within the polymer matrix is ascribed to the formation of a bridge-linked network via Si–O–Ti bonds between KH560 and LLTO, and plenty of hydrogen bonds within the polymer matrix. This modification method provides a feasible strategy for fabricating GHEs with good repeatability, which may easily adapt to the high requirements of commercial production.

BackgroundStroke is the leading cause of death and disability worldwide, with ischemic stroke (IS) being the most prevalent type. Circular RNAs (circRNAs) are involved in the pathological process of IS and are promising biomarkers for the diagnosis of IS. However, studies focusing on circRNAs acting as microRNAs (miRNAs) sponges in regulating mRNA expression are currently scarce.MethodsIn this study, expression profiles of circRNAs (GSE195442), miRNAs (GSE117064), and mRNAs (GSE58294) from the Gene Expression Omnibus (GEO) database were analyzed. Differentially expressed circRNAs (DEcircRNAs), differentially expressed miRNAs (DEmiRNAs), and differentially expressed mRNAs (DEmRNAs) were identified by R software. The target miRNAs and target genes were predicted by several bioinformatics methods. Then, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the DEmRNAs. Subsequently, the protein-protein interaction (PPI) network and the competing endogenous RNA (ceRNA) regulatory network were visualized by Cytoscape software. Finally, we further constructed an immune-related circRNA-miRNA-mRNA regulatory sub-network in IS.ResultsA total of 35 DEcircRNAs, 141 DEmiRNAs, and 356 DEmRNAs were identified. By comprehensive analysis of bioinformatics methods, we constructed a circRNA-miRNA-mRNA regulatory network, including 15 DEcircRNAs, eight DEmiRNAs, and 39 DEmRNAs. FGF9 was identified as an immune-related hub gene. Immune cell analysis indicated a significantly higher level of neutrophils in IS, and the expression of FGF9 was significantly negatively correlated with the level of neutrophils. Eventually, miR-767-5p was predicted as the upstream molecules of FGF9, and circ_0127785 and circ_0075008 were predicted as the upstream circRNAs of miR-767-5p.ConclusionOur study provides novel insights into the molecular mechanisms governing the progression of IS from the perspective of immune-related ceRNA networks.

Optical phased array (OPA) can achieve beam steering by controlling the phase distribution of each channel. In traditional OPA, 2π phase tuning range is required to achieve beam steering. However, large phase tuning range can lead to large size, high power consumption, high operating voltage and low speed. Moreover, the performance of OPA with small phase tuning range, such as metasurface OPA, degrades greatly in traditional method. Here, we propose a design method of OPA with insufficient phase tuning range (10 dB side-mode suppression ratio (SMSR) can be achieved with any phase tuning range.

We propose and demonstrate a rectangular optical lattice filter with reconfigurable bandwidth and wavelength. The proposed reconfigurable rectangular lattice filter consists of three-stage cascaded ring-assisted Mach-Zehnder interferometers (RAMZIs), and each RAMZI unit serves as an approximate optical elliptical filter with optimized shape factor. The scheme and design principle are presented with the method of zero-pole theory. As a proof of concept, the proposed structure is fabricated on the Si3 N4 waveguide platform. In the experiment, the 3-dB bandwidth of the proposed filter can be continuously tuned from 14.1 GHz to 4.1 GHz, maintaining a rectangular transmission response, and the wavelength can also be continuously tuned. This reconfigurable rectangular optical lattice filter shows the potential in many practical applications for reconfigurable optical signal processing due to flexibility and reconfigurability.

Higher dimensional optical imaging has seen remarkable growth in the past decade. As a representative method, multiplexed structured illumination (MSI) has been widely introduced for its ultra-high resolution of high-dimensional information. In this letter, an imaging framework for recovering higher dimensional image data, which terms quadrature multiplexed structured illumination (QMSI), is proposed and demonstrated. QMSI incorporates the illumination pattern spatial phase information as a new parameter into the encoding process. This strategy can double the frequency spectrum utilization without any overhead compared to MSI, which means it can double the image sequence depth or image spatial resolution. As a proof of concept, we demonstrate the performance of QMSI by experiments on multispectral imaging.

Ghost imaging is a fascinating framework which constructs the image of an object by correlating measurements between received beams and reference beams, none of which carries the structure information of the object independently. Recently, by taking into account spacetime duality in optics, computational temporal ghost imaging has attracted attention. Here, we propose a novel Fourier temporal ghost imaging (FTGI) scheme to achieve single-shot nonreproducible temporal signals. By sinusoidal coded modulation, ghost images are obtained and recovered by applying Fourier transformation. For demonstration, non-repeating events are detected with single-shot exposure architecture. It is shown in experimental results that the peak signal-to-noise ratio (PSNR) of FTGI is significantly better (13 dB increase) than traditional temporal ghost imaging in the same condition. In addition, by using the obvious physical meaning of the Fourier spectrum, we show some potential applications of FTGI, such as frequency division multiplexing demodulation in the visible light communications.

Abstract Background Cancer cachexia as a metabolic syndrome can lead to at least 25% of cancer deaths. The inhibition of muscle atrophy is a main strategy to treat cancer cachexia. In this process, myostatin (MSTN) can exert a dual effect on protein metabolism, including inhibition of protein biosynthesis and enhancement of protein degradation. In this study, we will test the effect on muscle atrophy induced by cancer cachexia of IMB0901, a MSTN inhibitor. Methods Two high-throughput screening models against MSTN were developed. By screening, IMB0901, 2-((1-(3,4-dichlorophenyl)-1H-pyrazolo [3,4-d] pyrimidin-4-yl) amino) butan-1-ol, was picked out from the compound library. The in vitro cell model and the C26 animal model of muscle atrophy induced by cancer cachexia were used to determine the pharmacological activity of IMB0901. Whether IMB0901 could inhibit the aggravating effect of doxorubicin on muscle wasting was examined in vitro and in vivo. Results IMB0901 inhibited the MSTN promoter activity, the MSTN signaling pathway, and the MSTN positive feedback regulation. In atrophied C2C12 myotubes, IMB0901 had a potent efficiency of decreasing MSTN expression and modulating MSTN signaling pathway which was activated by C26-conditioned medium (CM). In C2C12 myotubes, the expressions of three common myotube markers, myosin heavy chain (MyHC), myogenic differentiation 1 (MyoD), and myogenin (MyoG), were downregulated by CM, which could be efficiently reversed by IMB0901 via reduction of ubiquitin-mediated proteolysis and enhancement of AKT/mTOR-mediated protein synthesis. In the C26 animal model, IMB0901 mitigated the weight loss of body, quadricep and liver, and protected the quadriceps cell morphology. Furthermore, IMB0901 decreased the expression of two E3 ligases Atrogin-1 and MuRF-1 in the quadriceps in vivo. At the cellular level, IMB0901 had no influence on anti-tumor effect of three chemotherapeutic agents (cisplatin, doxorubicin, and gemcitabine) and lowered doxorubicin-induced upregulation of MSTN in C2C12 myotubes. IMB0901 did not affect the inhibitory effect of doxorubicin on C26 tumor and delayed the weight loss of muscle and adipose tissue caused by C26 tumor and doxorubicin. Conclusions IMB0901 inhibits muscle atrophy induced by cancer cachexia by suppressing ubiquitin-mediated proteolysis and promoting protein synthesis. These findings collectively suggest that IMB0901 is a promising leading compound for the management of muscle atrophy induced by cancer cachexia.

A novel integrated on-chip wavelength-based beam emitter is proposed and fabricated to realize two-dimensional optical scanning. By combining both wavelength division filters and emission array, 80 × 8 far-field optical beam spots are achieved with a field of view of 6° × 4°. Both collimation and projection modes are tested and 64 wavelength channels are realized in 10 nm bandwidth from 1550 to 1560 nm. This device can be used for LIDAR, optical wireless communication, and high-speed infrared imaging applications.

The artificial intelligence (AI) techniques have been widely used in the transient stability analysis of a power system. They are recognized as the most promising approaches for predicting the post-fault transient stability status with the use of phasor measurement units data. However, the popular AI methods used for power systems are often “black boxes,” which result in the poor interpretation of the model. In this paper, a transient stability prediction method based on extreme gradient boosting is proposed. In this model, a decision graph and feature importance scores are provided to discover the relationship between the features of the power system and transient stability. Meanwhile, the key features are selected according to the feature importance scores to remove redundant variables. The simulation results on the New England 39-bus system have demonstrated the superiority of the proposed model over the prior methods in the computation speed and prediction accuracy. Finally, an algorithm is proposed to interpret the prediction results for a specific fault of the power system, which further improves the interpretability of the model and makes it attractive for real-time transient stability prediction.

A TiC2 solution was prepared by using an ultrasonic decomposition and nonlinear saturable absorption characteristics at about 2 μm were evaluated. A passively Q-switched (PQS) Tm:YAP laser was developed using the TiC2 material as a saturable absorber, and a 2220-mW average output power with a 579-ns pulse duration at 255 kHz was achieved in PQS mode, corresponding to 8.4% optical conversion efficiency. Also, an 8.7-μJ per pulse energy and a 15.0-W peak power were achieved from this PQS Tm:YAP laser. Furthermore, quality factors of vertical and horizontal beams from the Tm:YAP laser were less than 1.2 under two different modes of operation.

As an emerging paradigm in distributed power systems, microgrids provide promising solutions to local renewable energy generation and load demand satisfaction. However, the intermittency of renewables and temporal uncertainty in electrical load create great challenges to energy scheduling, especially for small-scale microgrids. Instead of deploying stochastic models to cope with such challenges, this paper presents a retroactive approach to real-time energy scheduling, which is prediction-independent and computationally efficient. Extensive case studies were conducted using 3-year-long real-life system data, and the results of simulations show that the cost difference between the proposed retroactive approach and perfect dispatch is less than 11% on average, which suggests better performance than model predictive control with the cost difference at 30% compared to the perfect dispatch.

An opto-electronic neural network is designed for video object detection from a long-exposure blurred image. This network combines an optical encoder, convolutional neural network decoder, and object detection module, which are jointly optimized end-to-end. The joint loss is adopted for updating the network according to the physical constraints of hardware via back-propagation. A high-speed refreshed spatial light modulator is used as the encoder part of the network to generate coded sub-images, and then, a single blurred image is obtained after a common camera. The rest of the network is used for video object detection. Both simulations and experiments demonstrate that our framework can successfully retrieve object labels and bounding boxes at different moments in the long exposure. To the best of our knowledge, this is the first work investigating video object detection from a single motion-degraded image.

Sichuan, China, has abundant genetic resources of sheep (Ovis aries). However, their genetic diversity and population structure have been less studied, especially at the genome-wide level. In the present study, we employed the specific-locus amplified fragment sequencing for identifying genome-wide single nucleotide polymorphisms (SNPs) among five breeds of sheep distributed in Sichuan, including three local pure breeds, one composite breed, and one exotic breed of White Suffolk. From 494 million clean paired-end reads, we obtained a total of 327,845 high-quality SNPs that were evenly distributed among all 27 chromosomes, with a transition/transversion ratio of 2.56. Based on this SNP panel, we found that the overall nucleotide diversity was 0.2284 for all five breeds, with the highest and lowest diversity observed in Mage sheep (0.2125) and Butuo Black (0.1963) sheep, respectively. Both Wright's fixation index and Identity-by-State distance revealed that all individuals of Liangshan Semifine-wool, White Suffolk, and Butuo Black sheep were respectively clustered together, and the breeds could be separated from each other, whereas Jialuo and Mage sheep had the closest genetic relationship and could not be distinguished from each other. In conclusion, we provide a reference panel of genome-wide and high-quality SNPs in five sheep breeds in Sichuan, by which their genetic diversity and population structures were investigated.

The fermentation processes of algicidal bacteria offer an eco-friendly and promising approach for controlling harmful algae blooms (HABs). The strain Ba3, previously isolated and identified as Bacillus sp., displays robust algicidal activity against HABs dinoflagellate in particular. Microbial fermentation products have also been found to provide metabolites with multiple bioactivities, which has been shown to reduce harmful algae species’ vegetative cells and thus reduce red tide outbreaks. In this study, the microbial fermentation of algicidal bacterium Ba3 was analyzed for its potential ability of algicidal compounds. A treatment time increased the algicidal efficiency of the fermentation products against Prorocentrum donghaiense (91%) and Alexandrium tamarense (82%). Among the treatment groups, the changing trend for the 2% treatment group was faster than that for the other treatments, showing that the inhibition rate could reach 99.1% in two days. Active components were separated by organic solvent extraction and macroporous resin, and the molecular weight of the active components was analyzed by LC-MS. The result shows that the microbial fermentation products offer a potential, not practical use for controlling the outbreaks of dinoflagellate blooms. As a result of its potential application for inhibiting HABs, these findings provide an encouraging basis for promoting large-scale fermentation production and the controlling the outbreaks of red tide.

As one of the most important optical filtering devices, Bragg gratings have been extensively used in various systems. A long Bragg grating is desired for many applications including frequency selection in semiconductor lasers and dispersion control for ultra-short pulses. As a prominent example, integrated spiral Bragg grating waveguides (SBGWs) have drawn much attention in the years. However, until now, the length of an integrated grating is still limited to a few milli-meters due to total waveguide loss. In this work, we propose and demonstrate a novel long chirped SBGW with waveguide loss as low as 0.05 dB/cm on a silicon nitride (Si3N4) platform. A 13.8 cm SBGW is fabricated, which is the longest on-chip waveguide grating reported so far. The SBGW’s reflection bandwidth is 9.2 nm from 1556.3 nm to 1565.5 nm, and it provides a total of 1440 ps group delay, that is, −156.5 ps/nm of dispersion. The group delay response shows great linearity and temperature stability. This integrated device holds great potential for various applications including in-line dispersion compensation, optical true delay phase array, and microwave photonics.

The demand for novel antibiotics is imperative for drug-resistant Gram-negative bacteria which causes diverse intractable infection disease in clinic. Here, a comprehensive screening was implemented to identify potential agents that disrupt the assembly of β-barrel outer-membrane proteins (OMPs) in the outer membrane (OM) of Gram-negative bacteria. The assembly of OMPs requires ubiquitous β-barrel assembly machinery (BAM). Among the five protein subunits in BAM, the interaction between BamA and BamD is essential for the function of this complex. We first established a yeast two-hybrid (Y2H) system to confirm the interaction between BamA and BamD, and then screened agents that specifically disrupt this interaction. From this screen, we identified a compound IMB-H4 that specially blocks BamA–BamD interaction and selectively inhibits the growth of Escherichia coli and other Gram-negative bacteria. Moreover, our results suggest that IMB-H4 disrupts BamA–BamD interaction by binding to BamA. Strikingly, E. coli cells having been treated with IMB-H4 showed impaired OM integrity and decreased the abundance of OMPs. Therefore, an antibacterial agent was identified successfully using Y2H system, and this compound likely blocks the assembly of OMPs by targeting BamA–BamD interaction in Gram-negative bacteria.

Five new sulfur-enriched alkaloids isatithioetherins A–E (1–5), and two pairs of scalemic enantiomers (+)- and (−)-isatithiopyrin B (6a and 6b) and isoepigoitrin and isogoitrin (7a and 7b), along with the known scalemic enantiomers epigoitrin and goitrin (8a and 8b), were isolated and characterized from an aqueous extract of the Isatis indigotica roots. Their structures were determined by extensive spectroscopic data analysis, including 2D NMR and theoretical calculations of electronic circular dichroism (ECD) spectra based on the quantum-mechanical time-dependent density functional theory (TDDFT). Compounds 1–5 represent a novel group of sulfur-enriched alkaloids, biogenetically originating from stereoselective assemblies of epigoitrin-derived units. Isolation and structure characterization of 6a and 6b support the postulated biosynthetic pathways for the diastereomers 9a and 9b via a rare thio-Diels–Alder reaction. Compounds 2 and 4 showed antiviral activity against the influenza virus A/Hanfang/359/95 (H3N2, IC50 0.60 and 1.92 μmol/L) and the herpes simplex virus 1 (HSV-1, IC50 3.70 and 2.87 μmol/L), and 2 also inhibited Coxsackie virus B3 (IC50 0.71 μmol/L). KEY WORDS: Cruciferae, Isatis indigotica, Sulfur-containing alkaloids, Isatithioetherins A–E, Isatithiopyrins A and B, Isoepigoitrin, Isogoitrin, Antiviral activity

The structural parameters for the cyclobutanoQ[5–8] family were determined through single crystal X-ray diffraction. It was found that the electropositive cyclobutano methylene protons (CH2) are important in forming interlinking crystal packing arrangements driven by the dipole–dipole interactions between these protons and the portal carbonyl O of a near neighbor. This type of interaction was observed across the whole family. Electrostatic potential maps also confirmed the electropositive nature of the cyclobutano CH2 but, more importantly, it was established that the cavities are electronegative in contrast to classical Q[5–8], which are near neutral.

Six new indole alkaloid sulfonic acids (1–6), together with two analogues (7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95 (H3N2), respectively.

A pair of new diphenyl glycerol ether enantiomers (−)-1 and (+)-1 and two new methyl benzamidobenzoates 2 and 3, named (−)-(R)- and (+)-(S)-isatindigotrioic acid [(−)-1 and (+)-1] and isatindigoticamides A (2) and B (3), respectively, were isolated from an aqueous decoction of the roots of Isatis indigotica (ban lan gen). Their structures were elucidated by spectroscopic data analysis including 2D NMR experiments. The absolute configurations of (−)-1 and (+)-1 were assigned based on the CD exciton chirality method. Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC50 values of 4.87 and 25.87 μmol/L, respectively. Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production.

Single-pixel imaging (SPI) exploits the sparsity structure of natural images and enables image acquisition with far fewer measurements than the number of pixels. However, current SPI devices suffer from low imaging speed and an extremely time-consuming image reconstruction operation. Photonic time-stretch (PTS) technique is demonstrated to enable high-speed structured-illumination pattern generation, which significantly accelerates the imaging speed of conventional SPI devices. Meanwhile, to achieve fast image reconstruction, phase-shifted sinusoidal illumination patterns are used to acquire the Fourier spectrum of images and then a simple inverse fast Fourier transform (IFFT) operation is required for image reconstruction, which is quite computationally efficient. This paper presents a high-speed real-time compressive imaging system and its applications to imaging flow cytometry. Not only is a 625-kHz frame rate demonstrated, which is three orders of magnitude higher than that of a conventional SPI device, but the reconstruction process is remarkably accelerated as well, which enables our prototype system to operate in real time.

Abstract Exploration of high‐performance cathode materials for rechargeable aqueous Zn ion batteries (ZIBs) is highly desirable. The potential of molybdenum trioxide (MoO3) in other electrochemical energy storage devices has been revealed but held understudied in ZIBs. Herein, a demonstration of orthorhombic MoO3 as an ultrahigh‐capacity cathode material in ZIBs is presented. The energy storage mechanism of the MoO3 nanowires based on Zn2+ intercalation/deintercalation and its electrochemical instability mechanism are particularly investigated and elucidated. The severe capacity decay of the MoO3 nanowires during charging/discharging cycles arises from the dissolution and the structural collapse of MoO3 in aqueous electrolyte. To this end, an effective strategy to stabilize MoO3 nanowires by using a quasi‐solid‐state poly(vinyl alcohol)(PVA)/ZnCl2 gel electrolyte to replace the aqueous electrolyte is developed. The capacity retention of the assembled ZIBs after 400 charge/discharge cycles at 6.0 A g−1 is significantly boosted, from 27.1% (in aqueous electrolyte) to 70.4% (in gel electrolyte). More remarkably, the stabilized quasi‐solid‐state ZIBs achieve an attracting areal capacity of 2.65 mAh cm−2 and a gravimetric capacity of 241.3 mAh g−1 at 0.4 A g−1, outperforming most of recently reported ZIBs.

Three pairs of enantiomerically pure alkaloids with diverse structure features, named isatindigoticoic acid A and epiisatindigoticoic acid A [(−)-1 and (+)-1], phaitanthrin A and epiphaitanthrin A [(−)-2 and (+)-2], and isatindopyrromizol A and epiisatindopyrromizol A [(−)-3 and (+)-3], respectively, were isolated from an aqueous extract of the roots of Isatis indigotica. Racemic and scalemic mixtures of these enantiomers were separated by HPLC on a chiral semi-preparative column. Their structures including absolute configurations were determined by extensive spectroscopic analysis in conjunction with the calculation of electronic circular dichroism (ECD) spectra. The enantiomer pairs possess parent structures of 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid, indolo[2,1-b]quinazolinone, and 3-thioxohexahydro-1H-pyrrolo[1,2-c]imidazol-1-one, respectively. Except for phaitanthrin A [(−)-2] which the configuration was previously undetermined, these compounds are new enantiomeric natural products.

An all-optical orthogonal frequency-division multiplexing (OFDM) demultiplexer based on silicon-on-insulator (SOI) waveguide technology is proposed and experimentally demonstrated. Such an integrated structure performing a discrete Fourier transform (DFT) not only has the advantages of a smaller volume and better stability but can also handle more optical subcarriers by increasing the number of the cascaded Mach-Zehnder interferometer (MZI) stages. An SOI-based eight-channel OFDM demultiplexer has been successfully fabricated with a free spectrum range (FSR) of approximately 64 GHz. Eight-subcarrier optical OFDM signals with non-return-to-zero (NRZ) formats are successfully detected by the proposed demultiplexer after a 30-km fiber-link transmission. The total modulation speed is 64 Gbaud, and the bit error rate (BER) performance of each subcarrier is also measured.

We propose and demonstrate a versatile, low-loss, polarization-insensitive, and wideband mode converter that can be utilized for mode conversion as a basic component in various photonic integrated circuits. The proposed converter is comprised of two reverse wedge-shaped waveguides and can be easily fabricated by a standard fabrication process. To verify its good performance and universality, we present two applications, including power coupling between a laser diode and a waveguide on the TriPleX platform and mode conversion between a strip waveguide and a slot waveguide on a silicon-on-insulator platform. For both examples, the insertion loss is less than -0.12 dB and -0.5 dB at around 1550 nm for the transverse electric (TE) mode and the transverse magnetic (TM) mode, respectively, by numerically study. Moreover, it maintains very low loss across a wavelength range of 300 nm for both polarization modes.

Signal processors are one of the significant elements in microwave photonic frontends，which determines the working ability of the entire system in many aspects.The silicon-photonics-based signal processors are especially attractive for their compact size and wonderful performance.The development of silicon-photonics-based signal processing for microwave photonic frontends was reviewed.