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Background: Flow altering angiographic procedures suffer from ill‐defined, qualitative endpoints. Quantitative digital subtraction angiography (qDSA) is an emerging technology that aims to address this issue by providing intra‐procedural blood velocity measurements from time‐resolved, 2D angiograms. To date, qDSA has used 30 frame/s DSA imaging, which is associated with high radiation dose rate compared to clinical diagnostic DSA (up to 4 frame/s). Purpose: The purpose of this study is to demonstrate an interleaved x‐ray imaging method which decreases the radiation dose rate associated with high frame rate qDSA while simultaneously providing low frame rate diagnostic DSA images, enabling the acquisition of both datasets in a single image sequence with a single injection of contrast agent. Methods: Interleaved x‐ray imaging combines low radiation dose image frames acquired at a high rate with high radiation dose image frames acquired at a low rate. The feasibility of this approach was evaluated on an x‐ray system equipped with research prototype software for x‐ray tube control. qDSA blood velocity quantification was evaluated in a flow phantom study for two lower dose interleaving protocols (LD1: 3.7±0.02mGy/s$3.7 \pm 0.02\ {\mathrm{mGy}}/{\mathrm{s}}$ and LD2: 1.7±0.04mGy/s$1.7 \pm 0.04{\mathrm{\ mGy}}/{\mathrm{s}}$) and one conventional (full dose) protocol (11.4±0.04mGy/s)$11.4 \pm 0.04{\mathrm{\ mGy}}/{\mathrm{s}})$. Dose was measured at the interventional reference point. Fluid velocities ranging from 24 to 45 cm/s were investigated. Gold standard velocities were measured using an ultrasound flow probe. Linear regression and Bland‐Altman analysis were used to compare ultrasound and qDSA. Results: The LD1 and LD2 interleaved protocols resulted in dose rate reductions of −67.7% and −85.5%, compared to the full dose qDSA scan. For the full dose protocol, the Bland‐Altman limits of agreement (LOA) between qDSA and ultrasound velocities were [0.7, 6.7] cm/s with a mean difference of 3.7 cm/s. The LD1 interleaved protocol results were similar (LOA: [0.3, 6.9] cm/s, bias: 3.6 cm/s). The LD2 interleaved protocol resulted in slightly larger LOA: [−2.5, 5.5] cm/s with a decrease in the bias: 1.5 cm/s. Linear regression analysis showed a strong correlation between ultrasound and qDSA derived velocities using the LD1 protocol, with a R2${R}^2$ of 0.96$0.96$, a slope of 1.05$1.05$ and an offset of 1.9$1.9$ cm/s. Similar values were also found for the LD2 protocol, with a R2${R}^2$ of 0.93$0.93$, a slope of 0.98$0.98$ and an offset of 2.0$2.0$ cm/s. Conclusions: The interleaved method enables simultaneous acquisition of low‐dose high‐rate images for intra‐procedural blood velocity quantification (qDSA) and high‐dose low‐rate images for vessel morphology evaluation (diagnostic DSA). [ABSTRACT FROM AUTHOR]