5,471 results on '"Miners A"'
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2. Biographical Notes
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
3. Conclusion
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
4. Back cover
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
- Published
- 2023
5. Part 4 / Evaluation and research into Child Advocacy Centre models
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
6. Chapter 15 / Key findings from a 20-month evaluation of a co-located multidisciplinary team within an urban Canadian Child & Youth Advocacy Centre
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
7. Chapter 14 / Evaluating and monitoring the implementation of the first Child Advocacy Centre in the Quebec City region: When evaluation goes hand-in-hand with the institution's activities
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
- Published
- 2023
8. Chapter 16 / Utilization of therapy at a Child Advocacy Centre following suspected/substantiated child sexual abuse
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
9. Chapter 13 / Innovative responses to problematic sexual behaviour of youth: Children's Advocacy Centres in North America
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
10. Chapter 6 / Access, inclusion, equity: Creating a strategy for a culturally responsive Child and Youth Advocacy Centre (CYAC) through inquiry and action
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
11. List of figures
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
12. List of tables
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
13. Part 3 / Prevention and therapeutic services in the context of Child Advocacy Centre models
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
14. Chapter 1 / Children's Advocacy Centres and child forensic interview protocols
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
15. Table of contents
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
16. Part 1 / Overall state of play
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
17. Introduction
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
18. Acknowledgements
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
19. Title Page, Copyright
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
20. Chapter 11 / Increasing access and decreasing barriers to mental health services at Child Advocacy Centres through telehealth
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
21. Chapter 4 / From dissenting to conforming hybridity—Experiences from a justice sector-affiliated Barnahus model
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
22. Chapter 7 / Expanding the practice of extended forensic interviews: Addressing controversial issues with field professionals in program development
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
23. Chapter 12 / A Children's Advocacy Centre comprehensive initiative to increase engagement with children's mental health services
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
- Published
- 2023
24. Chapter 8 / Working with cases of sibling sexual abuse in the ultra-Orthodox community: The Jerusalem Child Advocacy Center model
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
- Published
- 2023
25. List of abbreviations and acronyms
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
- Published
- 2023
26. Chapter 3 / Providing support to child witnesses inside a Child Advocacy Centre setting
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
27. Chapter 9 / Reaching for the SKY: Lessons from the Safe Kids & Youth (SKY) Coordinated Response in adapting a Child and Youth Advocacy Centre model for a rural region
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
- Published
- 2023
28. Chapter 10 / Prevention education programs in Child Advocacy Centres: An examination of a program model and program development in Canada
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
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- 2023
29. Part 2 / Providing services for specific cases and social realities
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
- Published
- 2023
30. Chapter 2 / The forensic medical evaluation and the role of the medical practitioner in a Child and Youth Advocacy Centre: A Canadian perspective
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
- Published
- 2023
31. Chapter 5 / Barnahus in Ireland: Problematizing power, culture and collaboration
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Mooney Joseph, Johansson Susanna, Bakketeig Elisiv, Stefansen Kari, Murphy Janice, DeChief Lynda, Aronson Krysta, Miners Amber, Deurvorst Smith Tanya, Scott Tracy, Ornstein Amy, S. Goodman Gail, Kramer Miranda, Hardie Susan, Melinder Annika, Enriquez Rayna, Hartman Dana, Ariey-Jouglard Myriam, Walsh Wendy, Herbert James, Rimer Pearl, Nadeau Danielle, Cyr Mireille, Alain Marc, and St-Amand Annick
- Published
- 2023
32. Discrete choice experiments: An overview of experience to date in haemophilia
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Spoors John, Miners Alec, and Cairns John
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discrete choice experiment ,gene therapy ,haemophilia ,patient preference ,pharmaceutical ,review ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
The patient voice is an important consideration in the availability and choice of pharmaceuticals – however, how to capture this complex area and apply it formally within regulation, health technology assessment and reimbursement remains subject to ongoing debate. Patient preference studies such as discrete choice experiments (DCEs) are being utilised more frequently in healthcare and it is anticipated that patient preference data will be incorporated more frequently into regulatory submissions moving forward.
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- 2022
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33. A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease
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Tsartsalis, Stergios, Sleven, Hannah, Fancy, Nurun, Wessely, Frank, Smith, Amy M., Willumsen, Nanet, Cheung, To Ka Dorcas, Rokicki, Michal J., Chau, Vicky, Ifie, Eseoghene, Khozoie, Combiz, Ansorge, Olaf, Yang, Xin, Jenkyns, Marion H., Davey, Karen, McGarry, Aisling, Muirhead, Robert C. J., Debette, Stephanie, Jackson, Johanna S., Montagne, Axel, Owen, David R., Miners, J. Scott, Love, Seth, Webber, Caleb, Cader, M. Zameel, and Matthews, Paul M.
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- 2024
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34. Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer’s disease
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Van Hulle, Carol, Ince, Selvi, Okonkwo, Ozioma C., Bendlin, Barbara B., Johnson, Sterling C., Carlsson, Cynthia M., Asthana, Sanjay, Love, Seth, Blennow, Kaj, Zetterberg, Henrik, and Scott Miners, J.
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- 2024
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35. UDP-Glycosyltransferases
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Hulin, Julie-Ann, primary, Hu, Dong-Gui, additional, Miners, John Oliver, additional, Mackenzie, Peter Ian, additional, and Meech, Robyn, additional
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- 2024
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36. Neuroimaging in Acute Stroke (e-Stroke)
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St. Anne's University Hospital Brno, Czech Republic, Na Homolce Hospital, General University Hospital, Prague, Pardubice Hospital, University Hospital Hradec Kralove, University Hospital, Motol, University Hospital Kralovske Vinohrady, Hospital Pisek, Vitkovice Hospital, České Budějovice Hospital, Jihlava Hospital, Brno University Hospital, Karvina Miners Hospital, Regional Hospital Liberec, Vyskov Hospital, Thomayer University Hospital, Municipal Hospital Ostrava, Regional Hospital Mlada Boleslav, and Regional Hospital Pribram
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- 2023
37. Health-related quality of life among people who inject drugs in Australia
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Cheng, Qinglu, Bajis, Sahar, Cunningham, Evan, Shih, Sophy T. F., Schulz, Marcel, Marshall, Alison D., Martin, Natasha K., Miners, Alec, Hajarizadeh, Behzad, Wiseman, Virginia, Dore, Gregory J., and Grebely, Jason
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- 2023
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38. Correction to: an economic evaluation of two PCR-based respiratory panel assays for patients admitted to hospital with community-acquired pneumonia (CAP) in the UK, France and Spain
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Miners, Lisa, Huntington, Susie, Lee, Nathaniel, Turner, Katy M. E., and Adams, Elisabeth
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- 2023
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39. An economic evaluation of two PCR-based respiratory panel assays for patients admitted to hospital with community-acquired pneumonia (CAP) in the UK, France and Spain
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Miners, Lisa, Huntington, Susie, Lee, Nathaniel, Turner, Katy M. E., and Adams, Elisabeth
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- 2023
- Full Text
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40. The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells
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Shepherd, Freya R., Davies, Kate, Miners, Kelly L., Llewellyn-Lacey, Sian, Kollnberger, Simon, Redman, James E., Grant, Melissa M., Ladell, Kristin, Price, David A., and McLaren, James E.
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- 2023
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41. Angiotensin-converting enzyme 2 (ACE-2) is dysregulated in Alzheimer's disease but not Vascular dementia
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Ozge Guzel, Hannah Mary Tayler, James Scott Miners, and Patrick Gavin Kehoe
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Specialties of internal medicine ,RC581-951 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Introduction: The brain renin-angiotensin system (RAS) is dysregulated in dementia. We have previously shown that ACE-2, a central regulator of the protective counter-regulatory arm of RAS, is inversely associated with disease pathology in Alzheimer's disease (AD). We have investigated whether ACE-2 is similarly deficient in Vascular dementia (VaD) and mixed dementia (AD-VaD), in addition to AD. We also investigated whether ACE-2 is related to vascular pathology including CAA and SVD and explored whether ACE-2 varies according to gender, hypertension status, and ACE-2 genotype. Methods: We studied brain tissue (frontal cortex) from 147 dementia cases (AD (n=94), VaD (n=20) and AD-VaD (n=33)) and 104 age-matched non-demented controls from the South West Dementia Brain Bank, University of Bristol. Amyloid β (Aβ) and tau pathology and levels, had previously been measured by IHC and ELISA, respectively. ACE-2 protein levels were measured by ELISA, and ACE-2 enzyme activity was measured using a fluorometric sensolyte kit (Anaspec). ACE-1 activity was measured using a fluorogenic assay; Ang-II and Ang-(1-7) were measured by in-house direct ELISA. ACE-2 genotypes (rs2285666 and rs4240157) were obtained by PCR. Results: ACE-2 enzyme activity was significantly reduced in AD and AD-VaD cases (p
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- 2024
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42. Whole systems approaches to diet and healthy weight: A scoping review of reviews.
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Gavin Breslin, Olujoke Fakoya, Wendy Wills, Nigel Lloyd, Charis Bontoft, Amander Wellings, Sian Harding, John Jackson, Katherine Barrett, Adam P Wagner, Lisa Miners, Honey-Anne Greco, and Katherine E Brown
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Medicine ,Science - Abstract
BackgroundObesity is a global epidemic affecting all age groups, populations, and income levels across continents, though is known to disproportionately affect socioeconomically disadvantaged populations. The causes of obesity are complex, informed by diet and weight practices, but shaped by social, commercial, and environmental factors and government policy. Consequently, a Whole System Approach (WSA)-which considers the many causes of obesity and shifts the focus away from individuals as points of intervention and puts an emphasis on understanding and improving the system in which people live-is required. This scoping review of reviews aims to: determine how WSAs to diet and healthy weight have been implemented and evaluated nationally and internationally; to determine what models or theories have been used to implement WSAs; describe how WSAs have been evaluated; determine if WSAs are effective; and to identify the contribution of the public and/or service users in the development of WSAs.MethodSystematic searches were carried out using CINAHL, Scopus, PsycINFO (ProQuest), the Cochrane Library, and MEDLINE. Included review papers were those that focused on the application of a whole system approach to diet and/or healthy weight, and/or reported the theory/model used to implement or simulate this approach. Databases were searched from 1995 to March 2022 using a combination of text and Medical Subject Headings (MeSH terms). In addition, reference sections of identified articles were examined for additional relevant articles. Covidence software was used to screen titles and abstracts from the electronic databases and resolve conflicts.ResultsA total of 20,308 articles were initially retrieved; after duplicate removal 7,690 unique title and abstracts were reviewed, and 110 articles were selected for full text review. On completion of full text review, 8 review articles were included for data extraction. These included: one umbrella review, four systematic reviews, a rapid review, and two literature reviews (one of which was on strategic reports written for government and public health policy). Evaluations of WSA were mainly process evaluations although health outcomes were assessed in some studies. Several conceptual frameworks or mathematical modelling approaches have been applied to WSAs for diet, healthy weight, and obesity to inform their planning or delivery, and to understand/map the associated systems. Common mathematical approaches include agent based or System Dynamic Modelling. Underlying both conceptual and mathematical models is an understanding how the elements of the complex systems impact each other to affect diet, healthy weight, and obesity. WSA implementations have reported some success in positively impacting health outcomes including reducing Body Mass Index, reducing sugary food intake, and increasing physical activity. Public and user involvement in WSA was not widely reported.ConclusionThe application of WSA to diet and healthy weight shows promise, yet the research is lagging behind their implementation. Further robust evidence for using WSA to address diet and healthy weight are required, including incorporating process and outcome evaluations (perhaps using established approaches such as Systems Dynamic Modelling). Furthermore, the analysis of epidemiological data alongside longitudinal process and outcome evaluation regarding the implementation of a WSA is required.
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- 2024
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43. Complement dysregulation is a prevalent and therapeutically amenable feature of long COVID
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Baillie, Kirsten, Davies, Helen E., Keat, Samuel B.K., Ladell, Kristin, Miners, Kelly L., Jones, Samantha A., Mellou, Ermioni, Toonen, Erik J.M., Price, David A., Morgan, B. Paul, and Zelek, Wioleta M.
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- 2024
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44. Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial
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Judge, PK, Staplin, N, Mayne, KJ, Wanner, C, Green, JB, Hauske, SJ, Emberson, JR, Preiss, D, Ng, SYA, Roddick, AJ, Sammons, E, Zhu, D, Hill, M, Stevens, W, Wallendszus, K, Brenner, S, Cheung, AK, Liu, ZH, Li, J, Hooi, LS, Liu, WJ, Kadowaki, T, Nangaku, M, Levin, A, Cherney, D, Maggioni, AP, Pontremoli, R, Deo, R, Goto, S, Rossello, X, Tuttle, KR, Steubl, D, Massey, D, Landray, MJ, Baigent, C, Haynes, R, Herrington, WG, Abat, S, Abd Rahman, R, Abdul Cader, R, Abdul Hafidz, MI, Abdul Wahab, MZ, Abdullah, NK, Abdul-Samad, T, Abe, M, Abraham, N, Acheampong, S, Achiri, P, Acosta, JA, Adeleke, A, Adell, V, Adewuyi-Dalton, R, Adnan, N, Africano, A, Agharazii, M, Aguilar, F, Aguilera, A, Ahmad, M, Ahmad, MK, Ahmad, NA, Ahmad, NH, Ahmad, NI, Ahmad Miswan, N, Ahmad Rosdi, H, Ahmed, I, Ahmed, S, Aiello, J, Aitken, A, AitSadi, R, Aker, S, Akimoto, S, Akinfolarin, A, Akram, S, Alberici, F, Albert, C, Aldrich, L, Alegata, M, Alexander, L, Alfaress, S, Alhadj Ali, M, Ali, A, Alicic, R, Aliu, A, 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45. Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the empa-kidney trial
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Staplin, N, Haynes, R, Judge, PK, Wanner, C, Green, JB, Emberson, J, Preiss, D, Mayne, KJ, Ng, SYA, Sammons, E, Zhu, D, Hill, M, Stevens, W, Wallendszus, K, Brenner, S, Cheung, AK, Liu, ZH, Li, J, Hooi, LS, Liu, WJ, Kadowaki, T, Nangaku, M, Levin, A, Cherney, D, Maggioni, AP, Pontremoli, R, Deo, R, Goto, S, Rossello, X, Tuttle, KR, Steubl, D, Petrini, M, Seidi, S, Landray, MJ, Baigent, C, Herrington, WG, Abat, S, Abd Rahman, R, Abdul Cader, R, Abdul Hafidz, MI, Abdul Wahab, MZ, Abdullah, NK, Abdul-Samad, T, Abe, M, Abraham, N, Acheampong, S, Achiri, P, Acosta, JA, Adeleke, A, Adell, V, Adewuyi-Dalton, R, Adnan, N, Africano, A, Agharazii, M, Aguilar, F, Aguilera, A, Ahmad, M, Ahmad, MK, Ahmad, NA, Ahmad, NH, Ahmad, NI, Ahmad Miswan, N, Ahmad Rosdi, H, Ahmed, I, Ahmed, S, Aiello, J, Aitken, A, AitSadi, R, Aker, S, Akimoto, S, Akinfolarin, A, Akram, S, Alberici, F, Albert, C, Aldrich, L, Alegata, M, Alexander, L, Alfaress, S, Alhadj Ali, M, Ali, A, Alicic, R, Aliu, A, Almaraz, R, 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Miyazawa, I, Mizumachi, R, Mizuno, M, Moffat, S, Mohamad Nor, FS, Mohamad Zaini, SN, Mohamed Affandi, FA, Mohandas, C, Mohd, R, Mohd Fauzi, NA, Mohd Sharif, NH, Mohd Yusoff, Y, Moist, L, Moncada, A, Montasser, M, Moon, A, Moran, C, Morgan, N, Moriarty, J, Morig, G, Morinaga, H, Morino, K, Morisaki, T, Morishita, Y, Morlok, S, Morris, A, Morris, F, Mostafa, S, Mostefai, Y, Motegi, M, Motherwell, N, Motta, D, Mottl, A, Moys, R, Mozaffari, S, Muir, J, Mulhern, J, Mulligan, S, Munakata, Y, Murakami, C, Murakoshi, M, Murawska, A, Murphy, K, Murphy, L, Murray, S, Murtagh, H, Musa, MA, Mushahar, L, Mustafa, R, Mustafar, R, Muto, M, Nadar, E, Nagano, R, Nagasawa, T, Nagashima, E, Nagasu, H, Nagelberg, S, Nair, H, Nakagawa, Y, Nakahara, M, Nakamura, J, Nakamura, R, Nakamura, T, Nakaoka, M, Nakashima, E, Nakata, J, Nakata, M, Nakatani, S, Nakatsuka, A, Nakayama, Y, Nakhoul, G, Naverrete, G, Navivala, A, Nazeer, I, Negrea, L, Nethaji, C, Newman, E, Ng, TJ, Ngu, LLS, Nimbkar, T, Nishi, H, Nishi, 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Poehler, D, Polese, L, Poma, V, Postal, A, Pötz, C, Power, A, Pradhan, N, Pradhan, R, Preiss, E, Preston, K, Prib, N, Price, L, Provenzano, C, Pugay, C, Pulido, R, Putz, F, Qiao, Y, Quartagno, R, Quashie-Akponeware, M, Rabara, R, Rabasa-Lhoret, R, Radhakrishnan, D, Radley, M, Raff, R, Raguwaran, S, Rahbari-Oskoui, F, Rahman, M, Rahmat, K, Ramadoss, S, Ramanaidu, S, Ramasamy, S, Ramli, R, Ramli, S, Ramsey, T, Rankin, A, Rashidi, A, Raymond, L, Razali, WAFA, Read, K, Reiner, H, Reisler, A, Reith, C, Renner, J, Rettenmaier, B, Richmond, L, Rijos, D, Rivera, R, Rivers, V, Robinson, H, Rocco, M, Rodriguez-Bachiller, I, Rodriquez, R, Roesch, C, Roesch, J, Rogers, J, Rohnstock, M, Rolfsmeier, S, Roman, M, Romo, A, Rosati, A, Rosenberg, S, Ross, T, Roura, M, Roussel, M, Rovner, S, Roy, S, Rucker, S, Rump, L, Ruocco, M, Ruse, S, Russo, F, Russo, M, Ryder, M, Sabarai, A, Saccà, C, Sachson, R, Sadler, E, Safiee, NS, Sahani, M, Saillant, A, Saini, J, Saito, C, Saito, S, Sakaguchi, K, Sakai, M, Salim, H, Salviani, C, Sampson, A, Samson, F, Sandercock, P, Sanguila, S, Santorelli, G, Santoro, D, Sarabu, N, Saram, T, Sardell, R, Sasajima, H, Sasaki, T, Satko, S, Sato, A, Sato, D, Sato, H, Sato, J, Sato, T, Sato, Y, Satoh, M, Sawada, K, Schanz, M, Scheidemantel, F, Schemmelmann, M, Schettler, E, Schettler, V, Schlieper, GR, Schmidt, C, Schmidt, G, Schmidt, U, Schmidt-Gurtler, H, Schmude, M, Schneider, A, Schneider, I, Schneider-Danwitz, C, Schomig, M, Schramm, T, Schreiber, A, Schricker, S, Schroppel, B, Schulte-Kemna, L, Schulz, E, Schumacher, B, Schuster, A, Schwab, A, Scolari, F, Scott, A, Seeger, W, Segal, M, Seifert, L, Seifert, M, Sekiya, M, Sellars, R, Seman, MR, Shah, S, Shainberg, L, Shanmuganathan, M, Shao, F, Sharma, K, Sharpe, C, Sheikh-Ali, M, Sheldon, J, Shenton, C, Shepherd, A, Shepperd, M, Sheridan, R, Sheriff, Z, Shibata, Y, Shigehara, T, Shikata, K, Shimamura, K, Shimano, H, Shimizu, Y, Shimoda, H, Shin, K, Shivashankar, G, Shojima, N, Silva, R, Sim, CSB, Simmons, K, Sinha, S, Sitter, T, Sivanandam, S, Skipper, M, Sloan, K, Sloan, L, Smith, R, Smyth, J, Sobande, T, Sobata, M, Somalanka, S, Song, X, Sonntag, F, Sood, B, Sor, SY, Soufer, J, Sparks, H, Spatoliatore, G, Spinola, T, Squyres, S, Srivastava, A, Stanfield, J, Staylor, K, Steele, A, Steen, O, Steffl, D, Stegbauer, J, Stellbrink, C, Stellbrink, E, Stevenson, A, Stewart-Ray, V, Stickley, J, Stoffler, D, Stratmann, B, Streitenberger, S, Strutz, F, Stubbs, J, Stumpf, J, Suazo, N, Suchinda, P, Suckling, R, Sudin, A, Sugamori, K, Sugawara, H, Sugawara, K, Sugimoto, D, Sugiyama, H, Sugiyama, T, Sullivan, M, Sumi, M, Suresh, N, Sutton, D, Suzuki, H, Suzuki, R, Suzuki, Y, Swanson, E, Swift, P, Syed, S, Szerlip, H, Taal, M, Taddeo, M, Tailor, C, Tajima, K, Takagi, M, Takahashi, K, Takahashi, M, Takahashi, T, Takahira, E, Takai, T, Takaoka, M, Takeoka, J, Takesada, A, Takezawa, M, Talbot, M, Taliercio, J, Talsania, T, Tamori, Y, Tamura, R, Tamura, Y, Tan, CHH, Tan, EZZ, Tanabe, A, Tanabe, K, Tanaka, A, Tanaka, N, Tang, S, Tang, Z, Tanigaki, K, Tarlac, M, Tatsuzawa, A, Tay, JF, Tay, LL, Taylor, J, Taylor, K, Te, A, Tenbusch, L, Teng, KS, Terakawa, A, Terry, J, Tham, ZD, Tholl, S, Thomas, G, Thong, KM, Tietjen, D, Timadjer, A, Tindall, H, Tipper, S, Tobin, K, Toda, N, Tokuyama, A, Tolibas, M, Tomita, A, Tomita, T, Tomlinson, J, Tonks, L, Topf, J, Topping, S, Torp, A, Torres, A, Totaro, F, Toth, P, Toyonaga, Y, Tripodi, F, Trivedi, K, Tropman, E, Tschope, D, Tse, J, Tsuji, K, Tsunekawa, S, Tsunoda, R, Tucky, B, Tufail, S, Tuffaha, A, Turan, E, Turner, H, Turner, J, Turner, M, Tye, YL, Tyler, A, Tyler, J, Uchi, H, Uchida, H, Uchida, T, Udagawa, T, Ueda, S, Ueda, Y, Ueki, K, Ugni, S, Ugwu, E, Umeno, R, Unekawa, C, Uozumi, K, Urquia, K, Valleteau, A, Valletta, C, van Erp, R, Vanhoy, C, Varad, V, Varma, R, Varughese, A, Vasquez, P, Vasseur, A, Veelken, R, Velagapudi, C, Verdel, K, Vettoretti, S, Vezzoli, G, Vielhauer, V, Viera, R, Vilar, E, Villaruel, S, Vinall, L, Vinathan, J, Visnjic, M, Voigt, E, von-Eynatten, M, Vourvou, M, Wada, J, Wada, T, Wada, Y, Wakayama, K, Wakita, Y, Walters, T, Wan Mohamad, WH, Wang, L, Wang, W, Wang, X, Wang, Y, Wanninayake, S, Watada, H, Watanabe, K, Watanabe, M, Waterfall, H, Watkins, D, Watson, S, Weaving, L, Weber, B, Webley, Y, Webster, A, Webster, M, Weetman, M, Wei, W, Weihprecht, H, Weiland, L, Weinmann-Menke, J, Weinreich, T, Wendt, R, Weng, Y, Whalen, M, Whalley, G, Wheatley, R, Wheeler, A, Wheeler, J, Whelton, P, White, K, Whitmore, B, Whittaker, S, Wiebel, J, Wiley, J, Wilkinson, L, Willett, M, Williams, A, Williams, E, Williams, K, Williams, T, Wilson, A, Wilson, P, Wincott, L, Wines, E, Winkelmann, B, Winkler, M, Winter-Goodwin, B, Witczak, J, Wittes, J, Wittmann, M, Wolf, G, Wolf, L, Wolfling, R, Wong, C, Wong, E, Wong, HS, Wong, LW, Wong, YH, Wonnacott, A, Wood, A, Wood, L, Woodhouse, H, Wooding, N, Woodman, A, Wren, K, Wu, J, Wu, P, Xia, S, Xiao, H, Xiao, X, Xie, Y, Xu, C, Xu, Y, Xue, H, Yahaya, H, Yalamanchili, H, Yamada, A, Yamada, N, Yamagata, K, Yamaguchi, M, Yamaji, Y, Yamamoto, A, Yamamoto, S, Yamamoto, T, Yamanaka, A, Yamano, T, Yamanouchi, Y, Yamasaki, N, Yamasaki, Y, Yamashita, C, Yamauchi, T, Yan, Q, Yanagisawa, E, Yang, F, Yang, L, Yano, S, Yao, S, Yao, Y, Yarlagadda, S, Yasuda, Y, Yiu, V, Yokoyama, T, Yoshida, S, Yoshidome, E, Yoshikawa, H, Young, A, Young, T, Yousif, V, Yu, H, Yu, Y, Yuasa, K, Yusof, N, Zalunardo, N, Zander, B, Zani, R, Zappulo, F, Zayed, M, Zemann, B, Zettergren, P, Zhang, H, Zhang, L, Zhang, N, Zhang, X, Zhao, J, Zhao, L, Zhao, S, Zhao, Z, Zhong, H, Zhou, N, Zhou, S, Zhu, L, Zhu, S, Zietz, M, Zippo, M, Zirino, F, and Zulkipli, FH
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- 2024
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46. The molecular basis of dapsone activation of CYP2C9-catalyzed nonsteroidal anti-inflammatory drug oxidation
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Nair, Pramod C., Burns, Kushari, Chau, Nuy, McKinnon, Ross A., and Miners, John O.
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- 2023
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47. The effect of combination prevention strategies on HIV incidence among gay and bisexual men who have sex with men in the UK: a model-based analysis
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Cambiano, Valentina, Miners, Alec, Lampe, Fiona C, McCormack, Sheena, Gill, O Noel, Hart, Graham, Fenton, Kevin A, Cairns, Gus, Thompson, Marc, Delpech, Valerie, Rodger, Alison J, and Phillips, Andrew N
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- 2023
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48. A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study
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Jackson, Heather Ruth, Zandstra, Judith, Menikou, Stephanie, Hamilton, Shea, McArdle, Andrew J, De, Tisham, Agyeman, Philipp K A, Von Both, Ulrich, Carrol, Enitan D, Emonts, Marieke, Eleftheriou, Irini, Van der Flier, Michiel, Fink, Colin, De Groot, Ronald, Moll, Henriette A, Pokorn, Marko, Pollard, Andrew, Schlapbach, Luregn J, Tsolia, Maria, Usuf, Effua, Wright, Victoria, Yeung, Shunmay, Zavadska, Dace, Zenz, Werner, Coin, Lachlan JM, Cunnington, Aubrey J, Martinon-Torres, Federico, Herberg, Jethro, De Jonge, Marien I, Levin, Michael, Kuijpers, Taco, Kaforou, Myrsini, Abdulla, Amina, Aebi, Christoph, Agbeko, Rachel, Ali, Ladan, Alkema, Wynand, Allen, Karen, Anderson, Suzanne, Ansari, Imran, Arif, Tasnim, Avramoska, Tanja, Baas, Bryan, Bahovec, Natalija, Balode, Anda, Bãrdzdina, Arta, Barendregt, A M, Barral-Arca, Ruth, Bath, David, Bauchinger, Sebastian, Baumard, Lucas, Baumgart, Hinrich, Baxter, Frances, Bell, Kathryn, Bell, Ashley, Bello, Xabier, Bellos, Evangelos, Benesch, Martin, Bennet, Joshua, Berger, Christoph, Bernhard-Stirnemann, Sara, Bibi, Sagida, Bidlingmaier, Christoph, Binder, Alexander, Binder, Vera, Blackmore, Jennifer, Bojang, Kalifa, Borensztajn, Dorine M, Brengel-Pesce, Karen, Broderick, Claire, Buschbeck, Judith, Calvo-Bado, Leonides, Carnota, Sandra, Carter, Michael J, Castro, María Barreiro, Cebey-López, Miriam, Ceesay, Samba, Ceolotto, Astrid, Chan, Adora, Cocklin, Elizabeth, Collings, Kalvin, Crulley, Stephen, Curras-Tuala, María José, D'alessandro, Umberto, D'Souza, Giselle, Danhauser, Katharina, Darboe, Saffiatou, Darnell, Sarah, De Haan, L, De Vries, Gabriella, Deksne, Dãrta, Devine, Kirsty, Dewez, Juan Emmanuel, Dik, W, Dudley, Julia, Eber, Ernst, Fabian, Daniel, Farto, Cristina Balo, Fernández, Sonia Serén, Fidler, Katy, Fitchett, Elizabeth, Galassini, Rachel, Gallisti, Siegfried, García, Mirian Ben, Gardovska, Dace, Geissler, J, Gerrits, G P J M, Giannoni, Eric, Gloerich, Jolein, Gómez-Carballa, Alberto, González, Fernando Álves, Gores, Gunther, Grãvele, Dagne, Griese, Matthias, Grope, Ilze, Gurung, Meeru, Haas, Nikolaus, Habgood-Coote, Dominic, Hagedoorn, Nienke N, Haidl, Harald, Harrison, Rebekah, Hauer, Almuthe, Heidema, J, Heininger, Ulrich, Henriet, Stefanie, Hibberd, Martin, Hoggart, Cllive, Hösele, Susanne, Hourmat, Sara, Hude, Christa, Huijnen, Martijn, Iglesias, Pilar Leboráns, Iglesias, Marisol Vilas, Jennings, Rebecca, Johnson, Joanne, Jongerius, Ilse, Jorgensen, Rikke, Kahlert, Christian, Kandasamy, Rama, Kappler, Matthias, Keldorfer, Markus, Kelly, Dominic F, Khanijau, Aakash, Kim, Nayoung, Kim, Eunjung, King, Sharon, Kolberg, Laura, Kolnik, Mojca, Kloosterhuis, Lieke, Kohlfürst, Daniela S, Kohlmaier, Benno, Krenn, Larissa, Leigh, Simon, Leitner, Manuel, Leurent, Baptiste, Lim, Emma, Lin, Naomi, Liu, Ching-Chuan, Löffler, Sabine, Lurz, Eberhard, Mackerness, Christine, Maconochie, Ian, Mallet, Francois, Marmarinos, Antonis, Martin, Alex, Martin, Mike, Martinón Sánchez, José María, Martinón-Torres, Nazareth, McAlinden, Paul, McDonald, Sam, McDonell, Anne, Meiere, Anija, Meierford, Anne, Miedema, C J, Miners, Alec, Mistry, Ravi, Mommert, Marine, Morris, Sophie, Muench, Georg, Murdoch, David R, Mustafa, Sobia, Natalucci, Giancarlo, Neeleman, C, Newall, Karen, Nichols, Samuel, Niederer-Loher, Anita, Niedrist, Tobias, Nijman, Ruud, Nokalna, Ieve, Nordberg, Gudrun, O'Connor, Daniel, Obihara, C C, Oliver, Zoe, Oosthoek, Wilma, Ora, Miguel Sadiki, Osterman, Veronika, Pachot, Alexandre, Pajkrt, D, Pardo-Seco, Jacobo, Pavãre, Jana, Paz, Ivonne Pena, Paulus, Stéphane, Pérez, Belén Mosquera, Persand, Salina, Pfleger, Andreas, Pfurtscheller, Klaus, Philipsen, Ria, Pickering, Alisa, Pierce, Benjamin, Pilch, Heidemarie, Pischedda, Sara, Pölz, Lena, Posfay-Barbe, Klara M, Powell, Oliver, Prunk, Petra, Pučuka, Zanda, Rajic, Glorija, Rashid, Aqeela, Redondo-Collazo, Lorenzo, Reiter, Karl, Relly, Christa, Rhodes, Mathew, Rial, Jose Gómez, Richmond, Vivien, Riedel, Thomas, Rivero Calle, Irene, Roca, Anna, Rödl, Siegfried, Rodríguez, Lidia Piñeiro, Rodríguez-Tenreiro, Carmen, Romaine, Sam, Rowlands, Emily, Rudzate, Aleksandra, Sagmeister, Manfred, Saidykhan, Momodou, Sallas, Antonio, Sarr, Isatou, Schoen, Carola, Schonenberg, D, Schweintzger, Nina, Secka, Fatou, Selecka, Katrīna, Shah, Priyen, Shen, Ching-Fen, Shrestha, Shrijana, Skrabl-Baumgartner, Andrea, Soon, Joshua, Sperl, Matthias, Sprenkeler, Evelien, Spyridis, Nikos, Srovin, Tina Plankar, Stampfer, Laura, Stevens, Molly, Stocker, Martin, Strenger, Volker, Suárez, Carlos Durán, Svile, Dace, Syggelou, Kelly, Tal, Chantal, Tambouratzi, Maria, Tavliavini, Emma, Thakker, Clare, Thomson, Evelyn, Throson, Stephen, Till, Holger, Tramper-Stranders, G A, Trasorras, Cristina Serén, Trobisch, Andreas, Urbãne, Urzula Nora, Usman, Mariama, Valentine, Lucille, Van Aerde, Koen, Van den Berg, J M, Van den Broek, Bryan, Van der Giessen, Ilona, Van der Kuip, M, Van der Velden, Fabian, Van Furth, A M, Van Gool, Alain J, Van Leur, M, van Mierlo, G, Vázquez, Sara Ray, Vermont, Clementien, Vicente, Luisa García, Vincek, Katarina, Vito, Ortensia, Voice, Marie, Wallia, Diane, Walsh, Ben, Wang, Shih-Min, Wedderburn, Catherine, Willems, Esther, Wilson, Clare, Wood, Amanda, Woodsford, Phil, Wyss, Verena, Xagorari, Marietta, Zachariasse, Joany, Zaman, Syed M A, Zurl, Christoph, Zwerenz, Manuela, Jackson, Heather R, Hamilton, Melissa Shea, Fischer, Roman, Thorne, Adam M, Huang, Honglei, Tanck, Michael W, Jansen, Machiel H, Pollard, Andrew J, Tsolia, Maria N, Wright, Victoria J, Coin, Lachlan J M, Casals-Pascual, Climent, Herberg, Jethro A, de Jonge, Marien I, and Kuijpers, Taco W
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- 2023
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49. The Evolving Nature of Health Technology Assessment: A Critical Appraisal of NICE’s New Methods Manual
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Angelis, Aris, Harker, Martin, Cairns, John, Seo, Mikyung Kelly, Legood, Rosa, Miners, Alec, Wiseman, Virginia, Chalkidou, Kalipso, Grieve, Richard, and Briggs, Andrew
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- 2023
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50. An economic evaluation of adaptive e-learning devices to promote weight loss via dietary change for people with obesity
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Miners Alec, Harris Jody, Felix Lambert, Murray Elizabeth, Michie Susan, and Edwards Phil
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Economic evaluation ,e-learning ,cost-utility analysis ,obesity and weight management. ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The prevalence of obesity is over 25 % in many developed countries. Obesity is strongly associated with an increased risk of fatal and chronic conditions such as cardiovascular disease and type 2 diabetes. Therefore it has become a major public health concern for many economies. E-learning devices are a relatively novel approach to promoting dietary change. The new generation of devices are ‘adaptive’ and use interactive electronic media to facilitate teaching and learning. E-Learning has grown out of recent developments in information and communication technology, such as the Internet, interactive computer programmes, interactive television and mobile phones. The aim of this study is to assess the cost-effectiveness of e-learning devices as a method of promoting weight loss via dietary change. Methods An economic evaluation was performed using decision modelling techniques. Outcomes were expressed in terms of Quality-Adjusted Life-Years (QALYs) and costs were estimated from a health services perspective. All parameter estimates were derived from the literature. A systematic review was undertaken to derive the estimate of relative treatment effect. Results The base case results from the e-Learning Economic Evaluation Model (e-LEEM) suggested that the incremental cost-effectiveness ratio was approximately £102,000 per Quality-Adjusted Life-Year (QALY) compared to conventional care. This finding was robust to most alternative assumptions, except a much lower fixed cost of providing e-learning devices. Expected value of perfect information (EVPI) analysis showed that while the individual level EVPI was arguably negligible, the population level value was between £37 M and £170 M at a willingness to pay between £20,000 to £30,000 per additional QALY. Conclusion The current economic evidence base suggests that e-learning devices for managing the weight of obese individuals are unlikely to be cost-effective unless their fixed costs are much lower than estimated or future devices prove to be much more effective.
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- 2012
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