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1. Sézary syndrome originates from heavily mutated hematopoietic progenitors

Author

Harro, Carly M., Sprenger, Kimberly B., Chaurio, Ricardo A., Powers, John J., Innamarato, Patrick, Anadon, Carmen M., Zhang, Yumeng, Biswas, Subir, Mandal, Gunjan, Mine, Jessica A., Cortina, Carla, Nagy, Mate Z., Martin, Alexandra L., Handley, Katelyn F., Borjas, Gustavo J., Chen, Pei-Ling, Pinilla-Ibarz, Javier, Sokol, Lubomir, Yu, Xiaoqing, and Conejo-Garcia, Jose R.

Published
2023
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3. Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells

Author

Anadon, Carmen M., Yu, Xiaoqing, Hänggi, Kay, Biswas, Subir, Chaurio, Ricardo A., Martin, Alexandra, Payne, Kyle K., Mandal, Gunjan, Innamarato, Patrick, Harro, Carly M., Mine, Jessica A., Sprenger, Kimberly B., Cortina, Carla, Powers, John J., Costich, Tara Lee, Perez, Bradford A., Gatenbee, Chandler D., Prabhakaran, Sandhya, Marchion, Douglas, Heemskerk, Mirjam H.M., Curiel, Tyler J., Anderson, Alexander R., Wenham, Robert M., Rodriguez, Paulo C., and Conejo-Garcia, Jose R.

Published
2022
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4. TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures

Author

Chaurio, Ricardo A., Anadon, Carmen M., Lee Costich, Tara, Payne, Kyle K., Biswas, Subir, Harro, Carly M., Moran, Carlos, Ortiz, Antonio C., Cortina, Carla, Rigolizzo, Kristen E., Sprenger, Kimberly B., Mine, Jessica A., Innamarato, Patrick, Mandal, Gunjan, Powers, John J., Martin, Alexandra, Wang, Zhitao, Mehta, Sumit, Perez, Bradford A., Li, Roger, Robinson, John, Kroeger, Jodi L., Curiel, Tyler J., Yu, Xiaoqing, Rodriguez, Paulo C., and Conejo-Garcia, Jose R.

Published
2022
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5. IgA transcytosis and antigen recognition govern ovarian cancer immunity

Author

Biswas, Subir, Mandal, Gunjan, Payne, Kyle K., Anadon, Carmen M., Gatenbee, Chandler D., Chaurio, Ricardo A., Costich, Tara Lee, Moran, Carlos, Harro, Carly M., Rigolizzo, Kristen E., Mine, Jessica A., Trillo-Tinoco, Jimena, Sasamoto, Naoko, Terry, Kathryn L., Marchion, Douglas, Buras, Andrea, Wenham, Robert M., Yu, Xiaoqing, Townsend, Mary K., Tworoger, Shelley S., Rodriguez, Paulo C., Anderson, Alexander R., and Conejo-Garcia, Jose R.

Published
2021
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6. Supplementary Data from Olfactory Receptor OR2H1 Is an Effective Target for CAR T Cells in Human Epithelial Tumors

Author

Martin, Alexandra L., primary, Anadon, Carmen M., primary, Biswas, Subir, primary, Mine, Jessica A., primary, Handley, Katelyn F., primary, Payne, Kyle K., primary, Mandal, Gunjan, primary, Chaurio, Ricardo A., primary, Powers, John J., primary, Sprenger, Kimberly B., primary, Rigolizzo, Kristen E., primary, Innamarato, Patrick, primary, Harro, Carly M., primary, Mehta, Sumit, primary, Perez, Bradford A., primary, Wenham, Robert M., primary, and Conejo-Garcia, Jose R., primary

Published
2023
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7. Supplementary Figure from Olfactory Receptor OR2H1 Is an Effective Target for CAR T Cells in Human Epithelial Tumors

Author

Martin, Alexandra L., primary, Anadon, Carmen M., primary, Biswas, Subir, primary, Mine, Jessica A., primary, Handley, Katelyn F., primary, Payne, Kyle K., primary, Mandal, Gunjan, primary, Chaurio, Ricardo A., primary, Powers, John J., primary, Sprenger, Kimberly B., primary, Rigolizzo, Kristen E., primary, Innamarato, Patrick, primary, Harro, Carly M., primary, Mehta, Sumit, primary, Perez, Bradford A., primary, Wenham, Robert M., primary, and Conejo-Garcia, Jose R., primary

Published
2023
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8. Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer

Author

Mandal, Gunjan, primary, Biswas, Subir, primary, Anadon, Carmen M., primary, Yu, Xiaoqing, primary, Gatenbee, Chandler D., primary, Prabhakaran, Sandhya, primary, Payne, Kyle K., primary, Chaurio, Ricardo A., primary, Martin, Alexandra, primary, Innamarato, Patrick, primary, Moran, Carlos, primary, Powers, John J., primary, Harro, Carly M., primary, Mine, Jessica A., primary, Sprenger, Kimberly B., primary, Rigolizzo, Kristen E., primary, Wang, Xuefeng, primary, Curiel, Tyler J., primary, Rodriguez, Paulo C., primary, Anderson, Alexander R., primary, Saglam, Ozlen, primary, and Conejo-Garcia, Jose R., primary

Published
2023
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9. Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice

Author

Harro, Carly M., Perez-Sanz, Jairo, Costich, Tara Lee, Payne, Kyle K., Anadon, Carmen M., Chaurio, Ricardo A., Biswas, Subir, Mandal, Gunjan, Rigolizzo, Kristen E., Sprenger, Kimberly B., Mine, Jessica A., Showe, Louise C., Yu, Xiaoqing, Liu, Kebin, Rodriguez, Paulo C., Pinilla-Ibarz, Javier, Sokol, Lubomir, and Conejo-Garcia, Jose R.

Subjects
Physiological aspects, Models, Development and progression, Genetic aspects, Health aspects, T cell lymphoma -- Models -- Genetic aspects -- Development and progression, Methyltransferases -- Physiological aspects -- Health aspects, Enzyme inhibitors -- Genetic aspects -- Health aspects, Transcription factors -- Physiological aspects -- Health aspects
Abstract

Introduction Peripheral T cell lymphomas (PTCLs) represent a collection of aggressive disorders with unfavorable outcome that account for approximately 12% of lymphoid tumors worldwide (1). Cutaneous T cell lymphoma (CTCL) [...], Cutaneous T cell lymphoma (CTCL) has a poorly understood etiology and no known cure. Using conditional knockout mice, we found that ablation of the genomic organizer special AT-rich sequence-binding protein 1 (Satb1) caused malignant transformation of mature, skin-homing, Notch-activated CD[4.sup.+] and CD[8.sup.+] T cells into progressively fatal lymphoma. Mechanistically, Satb1 restrained Stat5 phosphorylation and the expression of skin-homing chemokine receptors in mature T cells. Notably, methyltransferase-dependent epigenetic repression of SATB1 was universally found in human Sezary syndrome, but not in other peripheral T cell malignancies. H3K27 and H3K9 trimethylation occluded the SATB1 promoter in Sezary cells, while inhibition of SUV39H1/2 methyltransferases (unlike EZH2 inhibition) restored protective SATB1 expression and selectively abrogated the growth of primary Sezary cells more effectively than romidepsin. Therefore, inhibition of methyltransferases that silence SATB1 could address an unmet need for patients with mycosis fungoides/Sezary syndrome, a set of incurable diseases.

Published
2021
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10. Olfactory receptor OR5V1 is an effective target for CAR T cells in ovarian cancer (207)

Author

Martin, Alexandra, primary, Galindo, Carmen M Anadon, additional, Biswas, Subir, additional, Mine, Jessica, additional, Mandal, Gunjan, additional, Innamarato, Patrick, additional, Harro, Carly, additional, Powers, John, additional, Sprenger, Kimberly, additional, Handley, Katelyn, additional, Wenham, Robert, additional, and Conejo-Garcia, Jose, additional

Published
2022
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11. Utilization of immortalized B cells to identify SDCBP as a novel therapeutic target in ovarian carcinoma.

Author

Handley, Katelyn, primary, Mehta, Sumit, additional, Martin, Alexandra, additional, Biswas, Subir, additional, Maharaj, Kamira Karen, additional, Mine, Jessica A., additional, Cortina, Carla, additional, Nagy, Mate, additional, Sprenger, Kimberly, additional, Mandal, Gunjan, additional, Innamarato, Patrick, additional, Powers, John Joseph, additional, Harro, Carly M., additional, Chaurio, Ricardo A., additional, Anadon, Carmen M., additional, Pinilla-Ibarz, Javier, additional, Shahzad, Mian M., additional, Flores, Idhaliz, additional, and Conejo-Garcia, Jose, additional

Published
2022
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12. Olfactory Receptor OR2H1 Is an Effective Target for CAR T Cells in Human Epithelial Tumors

Author

Martin, Alexandra L., primary, Anadon, Carmen M., additional, Biswas, Subir, additional, Mine, Jessica A., additional, Handley, Katelyn F., additional, Payne, Kyle K., additional, Mandal, Gunjan, additional, Chaurio, Ricardo A., additional, Powers, John J., additional, Sprenger, Kimberly B., additional, Rigolizzo, Kristen E., additional, Innamarato, Patrick, additional, Harro, Carly M., additional, Mehta, Sumit, additional, Perez, Bradford A., additional, Wenham, Robert M., additional, and Conejo-Garcia, Jose R., additional

Published
2022
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13. Spontaneous class-switched antibody responses at endometrial cancer tumor bed drives superior patients’ outcome

Author

MANDAL, GUNJAN, primary, Biswas, Subir, additional, Anadon, Carmen M, additional, Yu, Xiaoqing, additional, Gatenbee, Chandler D, additional, Prabhakaran, Sandhya, additional, Payne, Kyle K, additional, Chaurio, Ricardo A, additional, Martin, Alexandra, additional, Innamarato, Patrick, additional, Moran, Carlos, additional, Powers, John J, additional, Harro, Carly M, additional, Mine, Jessica A, additional, Sprenger, Kimberly B, additional, Rigolizzo, Kristen E, additional, Wang, Xuefeng, additional, Curiel, Tyler J, additional, Rodriguez, Paulo C, additional, Anderson, Alexander R.A., additional, Saglam, Ozlen, additional, and Conejo-Garcia, Jose R, additional

Published
2022
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14. CAR T cells targeting Olfactory Receptor OR2H1 are an effective immunotherapeutic option in human epithelial tumors

Author

BISWAS, SUBIR, primary, Martin, Alexandra, additional, Galindo, Carmen Maria Anadon, additional, Mine, Jessica, additional, Payne, Kyle K, additional, Mandal, Gunjan, additional, Chaurio, Ricardo, additional, Powers, John J, additional, Sprenger, Kimberly, additional, Rigolizzo, Kristen E, additional, Innamarato, Patrick, additional, Harro, Carly, additional, Mehta, Sumit, additional, Perez, Bradford A, additional, Wenham, Robert M, additional, and Conejo-Garcia, Jose R, additional

Published
2022
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15. Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T-cells

Author

Galindo, Carmen Maria Anadon, primary, Yu, Xiaoqing, additional, Hanggi, kay, additional, Biswas, Subir, additional, Chaurio, Ricardo, additional, Mandal, Gunjan, additional, Martin, Alexandra, additional, Payne, Kyle K, additional, Innamarato, Pasquale P, additional, Harro, Carly M, additional, Mine, Jessica, additional, Sprenger, Kimberly, additional, Cortina, Carla, additional, Powers, John J, additional, Perez, Bradford A, additional, Gatenbee, Chandler D, additional, Prabhakaran, Sandhya, additional, Marchion, Douglas, additional, Heemskerk, Mirjam H, additional, Curiel, Tyler J, additional, Anderson, Alexander R.A., additional, Wenham, Robert M, additional, Rodriguez, Paulo C, additional, and Conejo-Garcia, Jose R, additional

Published
2022
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16. IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer

Author

Mandal, Gunjan, primary, Biswas, Subir, additional, Anadon, Carmen M., additional, Yu, Xiaoqing, additional, Gatenbee, Chandler D., additional, Prabhakaran, Sandhya, additional, Payne, Kyle K., additional, Chaurio, Ricardo A., additional, Martin, Alexandra, additional, Innamarato, Patrick, additional, Moran, Carlos, additional, Powers, John J., additional, Harro, Carly M., additional, Mine, Jessica A., additional, Sprenger, Kimberly B., additional, Rigolizzo, Kristen E., additional, Wang, Xuefeng, additional, Curiel, Tyler J., additional, Rodriguez, Paulo C., additional, Anderson, Alexander R., additional, Saglam, Ozlen, additional, and Conejo-Garcia, Jose R., additional

Published
2022
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18. SATB1 Expression Governs Follicular Helper T-cell-Triggered Tertiary Lymphoid Structure Assembly

Author

Chaurio, Ricardo A., primary, Anadon, Carmen M., additional, Costich, Tara L., additional, Payne, Kyle K., additional, Biswas, Subir, additional, Harro, Carly M., additional, Rigolizzo, Kristen E., additional, Moran, Carlos, additional, Ortiz, Antonio C., additional, Sprenger, Kimberly B., additional, Mine, Jessica A., additional, Mandal, Gunjan, additional, Powers, John J., additional, Innamarato, Pasquale P., additional, Martin, Alexandra, additional, Wang, Zhitao, additional, Mehta, Sumit, additional, Perez, Bradford A., additional, Li, Roger, additional, Robinson, John, additional, Kroeger, Jodi L., additional, Curiel, Tyler J., additional, Yu, Xiaoqing, additional, Rodriguez, Paulo C., additional, Conejo-Garcia, Jose R., additional, and Administrator, Sneak Peek, additional

Published
2021
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19. Ovarian Cancer Immunogenicity is Governed by a Narrow Subset of Progenitor Tissue-Resident Memory T-Cells

Author

Anadon, Carmen M., primary, Yu, Xiaoqing, additional, Biswas, Subir, additional, Chaurio, Ricardo A., additional, Hanggi, Kay, additional, Martin, Alexandra, additional, Payne, Kyle K., additional, Mandal, Gunjan, additional, Innamarato, Pasquale P., additional, Harro, Carly M., additional, Mine, Jessica A., additional, Sprenger, Kimberly B., additional, Powers, John J., additional, Costich, Tara L., additional, Perez, Bradford A., additional, Gatenbee, Chandler D., additional, Prabhakaran, Sandhya, additional, Marchion, Douglas, additional, Heemskerk, Mirjam HM, additional, Curiel, Tyler J., additional, Anderson, Alexander R.A., additional, Wenham, Robert M., additional, Rodriguez, Paulo C., additional, and Conejo-Garcia, Jose R., additional

Published
2021
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20. BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells

Author

Payne, Kyle K., primary, Mine, Jessica A., additional, Biswas, Subir, additional, Chaurio, Ricardo A., additional, Perales-Puchalt, Alfredo, additional, Anadon, Carmen M., additional, Costich, Tara Lee, additional, Harro, Carly M., additional, Walrath, Jennifer, additional, Ming, Qianqian, additional, Tcyganov, Evgenii, additional, Buras, Andrea L., additional, Rigolizzo, Kristen E., additional, Mandal, Gunjan, additional, Lajoie, Jason, additional, Ophir, Michael, additional, Tchou, Julia, additional, Marchion, Douglas, additional, Luca, Vincent C., additional, Bobrowicz, Piotr, additional, McLaughlin, Brooke, additional, Eskiocak, Ugur, additional, Schmidt, Michael, additional, Cubillos-Ruiz, Juan R., additional, Rodriguez, Paulo C., additional, Gabrilovich, Dmitry I., additional, and Conejo-Garcia, Jose R., additional

Published
2020
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21. Immune pressure against ovarian cancer depends on antigen-specific CD69+CD103+TRM T cells

Author

Galindo, Carmen Maria Anadon, primary, Yu, Xiaoqing, additional, Gonzalez, Ricardo A Chaurio, additional, Payne, Kyle K, additional, Biswas, Subir, additional, Costich, Tara Lee, additional, Perez-Sanz, Jairo, additional, Mandal, Gunjan, additional, Martin, Alexandra L, additional, Harro, Carly, additional, Powell, Chase, additional, Mine, Jessica A, additional, Wang, Zhitao, additional, and Conejo-Garcia, Jose, additional

Published
2020
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22. SATB1 as a novel therapeutic target for methyltransferase inhibitors against Cutaneous T Cell Lymphoma

Author

Harro, Carly, primary, Perez-Sanz, Jairo, additional, Costich, Tara Lee, additional, Payne, Kyle K, additional, Galindo, Carmen Maria Anadon, additional, Gonzalez, Ricardo A Chaurio, additional, Biswas, Subir, additional, Mandal, Gunjan, additional, Rigolizzo, Kristen E, additional, Mine, Jessica A, additional, Showe, Louise C, additional, Liu, Kebin, additional, Rodriguez, Paulo C, additional, Pinilla-Ibarz, Javier Lee, additional, Sokol, Lubomir, additional, and Conejo-Garcia, Jose R, additional

Published
2020
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23. Satb1 deficiency licenses TFH-differentiation and Tertiary Lymphoid Structure formation in cancer

Author

Gonzalez, Ricardo A Chaurio, primary, Payne, Kyle K, additional, Galindo, Carmen Maria Anadon, additional, Costich, Tara Lee, additional, Harro, Carly, additional, Birwas, Subir, additional, Rigolizzo, Kristen, additional, Mine, Jessica A, additional, Mandal, Gunjan, additional, Powell, Chase, additional, Martin, Alexandra L, additional, Wang, Zhitao, additional, Kroeger, Jodi, additional, Robinson, John, additional, Melendez, Johana, additional, Rodriguez, Paulo C, additional, and Conejo-Garcia, Jose R, additional

Published
2020
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24. Butyrophilin 3A1 is a Dynamic T Cell Regulator in Ovarian Cancer

Author

Payne, Kyle K, primary, Gonzalez, Ricardo Chaurio, additional, Sanz, Jairo Perez, additional, Galindo, Carmen Maria Anadon, additional, Biswas, Subir, additional, Mine, Jessica A, additional, Perales-Puchalt, Alfredo, additional, Tsiganov, Evgenii, additional, Costich, Tara Lee, additional, Harro, Carly M, additional, Marrs, Aubrey K, additional, Lajoie, Jason, additional, Li, Kun-Po, additional, Ophir, Michael, additional, Eskiocak, Ugur, additional, Schmidt, Michael, additional, Gabrilovich, Dmitry I, additional, and Conejo-Garcia, Jose R, additional

Published
2019
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25. Satb1 deficiency licenses TFH-differentiation

Author

Chaurio Gonzalez, Ricardo A, primary, Biswas, Subir, additional, Payne, Kyle K., additional, Galindo, Carmen Maria Anadon, additional, Costich, Tara Lee, additional, Perales-Puchalt, Alfredo, additional, Perez-Sanz, Jairo, additional, Harro, Carly M, additional, Mine, Jessica A, additional, Allegrezza, Michael J, additional, Svoronos, Nikolaos, additional, Kroeger, Jodi, additional, Robinson, John, additional, and Conejo-Garcia, Jose R, additional

Published
2019
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27. Genomes of ubiquitous marine and hypersaline Hydrogenovibrio, Thiomicrorhabdus and Thiomicrospira spp. encode a diversity of mechanisms to sustain chemolithoautotrophy in heterogeneous environments

Author

Scott, Kathleen M., primary, Williams, John, additional, Porter, Cody M. B., additional, Russel, Sydney, additional, Harmer, Tara L., additional, Paul, John H., additional, Antonen, Kirsten M., additional, Bridges, Megan K., additional, Camper, Gary J., additional, Campla, Christie K., additional, Casella, Leila G., additional, Chase, Eva, additional, Conrad, James W., additional, Cruz, Mercedez C., additional, Dunlap, Darren S., additional, Duran, Laura, additional, Fahsbender, Elizabeth M., additional, Goldsmith, Dawn B., additional, Keeley, Ryan F., additional, Kondoff, Matthew R., additional, Kussy, Breanna I., additional, Lane, Marannda K., additional, Lawler, Stephanie, additional, Leigh, Brittany A., additional, Lewis, Courtney, additional, Lostal, Lygia M., additional, Marking, Devon, additional, Mancera, Paola A., additional, McClenthan, Evan C., additional, McIntyre, Emily A., additional, Mine, Jessica A., additional, Modi, Swapnil, additional, Moore, Brittney D., additional, Morgan, William A., additional, Nelson, Kaleigh M., additional, Nguyen, Kimmy N., additional, Ogburn, Nicholas, additional, Parrino, David G., additional, Pedapudi, Anangamanjari D., additional, Pelham, Rebecca P., additional, Preece, Amanda M., additional, Rampersad, Elizabeth A., additional, Richardson, Jason C., additional, Rodgers, Christina M., additional, Schaffer, Brent L., additional, Sheridan, Nancy E., additional, Solone, Michael R., additional, Staley, Zachery R., additional, Tabuchi, Maki, additional, Waide, Ramond J., additional, Wanjugi, Pauline W., additional, Young, Suzanne, additional, Clum, Alicia, additional, Daum, Chris, additional, Huntemann, Marcel, additional, Ivanova, Natalia, additional, Kyrpides, Nikos, additional, Mikhailova, Natalia, additional, Palaniappan, Krishnaveni, additional, Pillay, Manoj, additional, Reddy, T.B.K., additional, Shapiro, Nicole, additional, Stamatis, Dimitrios, additional, Varghese, Neha, additional, Woyke, Tanja, additional, Boden, Rich, additional, Freyermuth, Sharyn K., additional, and Kerfeld, Cheryl A., additional

Published
2018
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28. Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy

Author

Perales-Puchalt, Alfredo, primary, Perez-Sanz, Jairo, additional, Payne, Kyle K, additional, Svoronos, Nikolaos, additional, Allegrezza, Michael J, additional, Chaurio, Ricardo A, additional, Anadon, Carmen, additional, Calmette, Joseph, additional, Biswas, Subir, additional, Mine, Jessica A, additional, Costich, Tara Lee, additional, Nickels, Logan, additional, Wickramasinghe, Jayamanna, additional, Rutkowski, Melanie R, additional, and Conejo-Garcia, Jose R, additional

Published
2018
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29. Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers.

Author

Biswas, Subir, Mandal, Gunjan, Anadon, Carmen M., Chaurio, Ricardo A., Lopez-Bailon, Luis U., Nagy, Mate Z., Mine, Jessica A., Hänggi, Kay, Sprenger, Kimberly B., Innamarato, Patrick, Harro, Carly M., Powers, John J., Johnson, Joseph, Fang, Bin, Eysha, Mostafa, Nan, Xiaolin, Li, Roger, Perez, Bradford A., Curiel, Tyler J., and Yu, Xiaoqing

Subjects
*IMMUNOGLOBULIN A, *IMMUNOGLOBULIN M, *IMMUNOGLOBULIN receptors, *EPITHELIAL cells, *CYTOPLASM, *CANCER cells
Abstract

Dimeric IgA (dIgA) can move through cells via the IgA/IgM polymeric immunoglobulin receptor (PIGR), which is expressed mainly on mucosal epithelia. Here, we studied the ability of dIgA to target commonly mutated cytoplasmic oncodrivers. Mutation-specific dIgA, but not IgG, neutralized KRASG12D within ovarian carcinoma cells and expelled this oncodriver from tumor cells. dIgA binding changed endosomal trafficking of KRASG12D from accumulation in recycling endosomes to aggregation in the early/late endosomes through which dIgA transcytoses. dIgA targeting of KRASG12D abrogated tumor cell proliferation in cell culture assays. In vivo , KRASG12D-specific dIgA1 limited the growth of KRASG12D-mutated ovarian and lung carcinomas in a manner dependent on CD8+ T cells. dIgA specific for IDH1R132H reduced colon cancer growth, demonstrating effective targeting of a cytoplasmic oncodriver not associated with surface receptors. dIgA targeting of KRASG12D restricted tumor growth more effectively than small-molecule KRASG12D inhibitors, supporting the potential of this approach for the treatment of human cancers. [Display omitted] • Dimeric IgA undergoes bona fide transcytosis through PIGR+ carcinoma cells • Dimeric IgA specifically neutralizes mutated oncogenes inside tumor cells • Oncodrivers are expelled outside tumor cells through altered endosomal trafficking • Mutation-specific dimeric IgA specifically abrogates tumor growth in vivo Despite their long half-life, therapeutic antibodies are considered ineffective against intracellular antigens. Biswas et al. demonstrate that dimeric IgA undergoes transcytosis through PIGR+ epithelial cancer cells and can be engineered for the specific targeting of intracellular mutated oncodrivers. Binding of mutation-specific IgA expels oncodrivers from the cytoplasm and promotes anti-tumor immunity. [ABSTRACT FROM AUTHOR]

Published
2023
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