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10 results on '"Minayoshi, Yuki"'

1. Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH

Author

Maeda, Hitoshi, Ishima, Yu, Saruwatari, Junji, Mizuta, Yuki, Minayoshi, Yuki, Ichimizu, Shota, Yanagisawa, Hiroki, Nagasaki, Taisei, Yasuda, Kengo, Oshiro, Shun, Taura, Manabu, McConnell, Matthew J., Oniki, Kentaro, Sonoda, Kayoko, Wakayama, Tomohiko, Kinoshita, Manabu, Shuto, Tsuyoshi, Kai, Hirofumi, Tanaka, Motohiko, Sasaki, Yutaka, Iwakiri, Yasuko, Otagiri, Masaki, Watanabe, Hiroshi, and Maruyama, Toru

Published
2022
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5. Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticles for the Treatment of Hepatitis

Author

Yasuda, Kengo, primary, Maeda, Hitoshi, additional, Kinoshita, Ryo, additional, Minayoshi, Yuki, additional, Mizuta, Yuki, additional, Nakamura, Yuka, additional, Imoto, Shuhei, additional, Nishi, Koji, additional, Yamasaki, Keishi, additional, Sakuragi, Mina, additional, Nakamura, Teruya, additional, Ikeda-Imafuku, Mayumi, additional, Iwao, Yasunori, additional, Ishima, Yu, additional, Ishida, Tatsuhiro, additional, Iwakiri, Yasuko, additional, Otagiri, Masaki, additional, Watanabe, Hiroshi, additional, and Maruyama, Toru, additional

Published
2023
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7. A Mannosylated, PEGylated Albumin as a Drug Delivery System for the Treatment of Cancer Stroma Cells

Author

Mizuta, Yuki, primary, Maeda, Hitoshi, additional, Ishima, Yu, additional, Minayoshi, Yuki, additional, Ichimizu, Shota, additional, Kinoshita, Ryo, additional, Fujita, Issei, additional, Kai, Takuma, additional, Hirata, Kenshiro, additional, Nakamura, Teruya, additional, Saruwatari, Junji, additional, Arima, Hidetoshi, additional, Watanabe, Hiroshi, additional, Otagiri, Masaki, additional, and Maruyama, Toru, additional

Published
2021
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8. Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions

Author

Minayoshi, Yuki, Maeda, Hitoshi, Yanagisawa, Hiroki, Hamasaki, Keisuke, Mizuta, Yuki, Nishida, Kento, Kinoshita, Ryo, Enoki, Yuki, Imafuku, Tadasi, Chuang, Victor Tuan Giam, Koga, Tomoaki, Fujiwara, Yukio, Takeya, Motohiro, Sonoda, Kayoko, Wakayama, Tomohiko, Taguchi, Kazuaki, Ishima, Yu, Ishida, Tatsuhiro, Iwakiri, Yasuko, Tanaka, Motohiko, Sasaki, Yutaka, Watanabe, Hiroshi, Otagiri, Masaki, and Maruyama, Toru

Abstract

Because of its multifaceted anti-inflammatory and immunomodulatory effects, delivering type-I interferon to Kupffer cells has the potential to function as a novel type of therapy for the treatment of various types of hepatitis. We report herein on the preparation of a Kupffer cell targeting type-I interferon, an albumin-IFNα2b fusion protein that contains highly mannosylated N-linked oligosaccharide chains, Man-HSA(D494N)-IFNα2b, attached by combining albumin fusion technology and site-directed mutagenesis. The presence of this unique oligosaccharide permits the protein to be efficiently, rapidly and preferentially distributed to Kupffer cells. Likewise IFNα2b, Man-HSA(D494N)-IFNα2b caused a significant induction in the mRNA levels of IL-10, IL-1Ra, PD-L1 in RAW264.7 cells and mouse isolated Kupffer cells, and these inductions were largely inhibited by blocking the interferon receptor. These data indicate that Man-HSA(D494N)-IFNα2b retained the biological activities of type-I interferon. Man-HSA(D494N)-IFNα2b significantly inhibited liver injury in Concanavalin A (Con-A)-induced hepatitis model mice, and consequently improved their survival rate. Moreover, the post-administration of Man-HSA(D494N)-IFNα2b at 2 h after the Con-A challenge also exerted hepato-protective effects. In conclusion, this proof-of-concept study demonstrates the therapeutic effectiveness and utility of Kupffer cell targeting type-I interferon against hepatitis via its anti-inflammatory and immunomodulatory actions.

Published
2019
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9. Repeated Administration of Kupffer Cells-Targeting Nanoantioxidant Ameliorates Liver Fibrosis in an Experimental Mouse Model

Author

Maeda, Hitoshi, primary, Minayoshi, Yuki, additional, Ichimizu, Shota, additional, Mizuta, Yuki, additional, Nagasaki, Taisei, additional, Matsusaka, Kotaro, additional, Oshiro, Shun, additional, Oniki, Kentaro, additional, Saruwatari, Junji, additional, Ishima, Yu, additional, Watanabe, Hiroshi, additional, Otagiri, Masaki, additional, and Maruyama, Toru, additional

Published
2020
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10. Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions

Author

Minayoshi, Yuki, primary, Maeda, Hitoshi, additional, Yanagisawa, Hiroki, additional, Hamasaki, Keisuke, additional, Mizuta, Yuki, additional, Nishida, Kento, additional, Kinoshita, Ryo, additional, Enoki, Yuki, additional, Imafuku, Tadasi, additional, Chuang, Victor Tuan Giam, additional, Koga, Tomoaki, additional, Fujiwara, Yukio, additional, Takeya, Motohiro, additional, Sonoda, Kayoko, additional, Wakayama, Tomohiko, additional, Taguchi, Kazuaki, additional, Ishima, Yu, additional, Ishida, Tatsuhiro, additional, Iwakiri, Yasuko, additional, Tanaka, Motohiko, additional, Sasaki, Yutaka, additional, Watanabe, Hiroshi, additional, Otagiri, Masaki, additional, and Maruyama, Toru, additional

Published
2018
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