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4. Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium

Author

Nomura Tomoe, Tahara Tomomitsu, Shiroeda Hisakazu, Minato Takahiro, Matsue Yasuhiro, Hayashi Ranji, Matsunaga Kazuhiro, Otsuka Toshimi, Nakamura Masakatsu, Toshikuni Nobuyuki, Shibata Tomoyuki, and Arisawa Tomiyasu more...

Subjects
HRH2, Genetic polymorphism, Aberrant DNA methylation, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Aberrant methylation patterns in CpG island are known to be influential in gene silencing. Histamine plays important physiological roles in the upper gastrointestinal tract and acts via the H2 receptor. We report an investigation into the effect of HRH2 promoter polymorphism (rs2607474 G > A) on the methylation of DAPK and CDH1. Methods Non cancerous gastric mucosa samples were obtained from 115 subjects with gastric cancer (GC) and 412 non-cancer subjects (non-GC). Methylation status of genes was determined by MSP. The genotyping of rs2607474 was performed by PCR-SSCP. Results Methylation of DAPK and CDH1 was observed in 296 and 246 subjects, respectively. The frequency of CDH1 methylation in the subjects with GC was significantly lower in cancer lesion than in non cancerous mucosa, whereas that of DAPK methylation was not different. The allelic distribution of rs2607474 was 401GG, 119GA and 7AA. The GG homozygote was associated with a significantly increased risk for methylation of both DAPK and CDH1 (p DAPK and CDH1 methylation. However, this genotype did not show an increased risk for the development of methylation of both genes in patients with GC. In H. pylori negative subjects, GG homozygote showed an increased risk for the methylation of both DAPK and CDH1 (p = 0.0074 and p = 0.0016, respectively), whereas this genotype was associated with an increased risk for the development of DAPK methylation in H. pylori positive subjects (p = 0.0018). In addition, in subjects older than 60 years of age, atrophy and metaplasia scores were significantly higher in the GG homozygote (p = 0.011 and p = 0.039, respectively) and a significant correlation was observed between age and atrophy or metaplasia. Conclusions Our results suggest that rs2607474 GG homozygote confers a significantly increased risk for age- and inflammation-related DAPK and CDH1 methylation. more...

Published
2013
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5. The combination of fatty liver and increased gamma-glutamyl transpeptidase levels as a risk factor for atherosclerotic plaque development in apparently healthy people

Author

KINOSHITA, Kaori, primary, TOSHIKUNI, Nobuyuki, additional, SAITO, Takashi, additional, HAYASHI, Nobuhiko, additional, MINATO, Takahiro, additional, MATSUE, Yasuhiro, additional, UEDA, Yoshimichi, additional, TSUCHISHIMA, Mutsumi, additional, and TSUTSUMI, Mikihiro, additional more...

Published
2019
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9. Reduced Uterine Perfusion Pressure (RUPP) Model of Preeclampsia in Mice

Author

Fushima, Tomofumi, primary, Sekimoto, Akiyo, additional, Minato, Takahiro, additional, Ito, Takuya, additional, Oe, Yuji, additional, Kisu, Kiyomi, additional, Sato, Emiko, additional, Funamoto, Kenichi, additional, Hayase, Toshiyuki, additional, Kimura, Yoshitaka, additional, Ito, Sadayoshi, additional, Sato, Hiroshi, additional, and Takahashi, Nobuyuki, additional more...

Published
2016
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13. Su1720 Differentiation of Alcoholic Liver Disease From Nonalcoholic Fatty Liver Disease Using a Logistic Regression Model Based on Clinical Parameters

Author

Toshikuni, Nobuyuki, primary, Hayashi, Nobuhiko, additional, Fukumura, Atsushi, additional, Matsue, Yasuhiro, additional, Minato, Takahiro, additional, Nomura, Tomoe, additional, Saito, Takashi, additional, Ozaki, Kazuaki, additional, Shiroeda, Hisakazu, additional, Tsuchishima, Mutsumi, additional, Arisawa, Tomiyasu, additional, and Tsutsumi, Mikihiro, additional more...

Published
2013
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14. Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1in the gastric epithelium

Author

Nomura, Tomoe, primary, Tahara, Tomomitsu, additional, Shiroeda, Hisakazu, additional, Minato, Takahiro, additional, Matsue, Yasuhiro, additional, Hayashi, Ranji, additional, Matsunaga, Kazuhiro, additional, Otsuka, Toshimi, additional, Nakamura, Masakatsu, additional, Toshikuni, Nobuyuki, additional, Shibata, Tomoyuki, additional, and Arisawa, Tomiyasu, additional more...

Published
2013
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15. Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese subjects

Author

Arisawa, Tomiyasu, primary, Tahara, Tomomitsu, additional, Shiroeda, Hisakazu, additional, Minato, Takahiro, additional, Matsue, Yasuhiro, additional, Saito, Takashi, additional, Fukuyama, Tomoki, additional, Otsuka, Toshimi, additional, Fukumura, Atsushi, additional, Nakamura, Masakatsu, additional, and Shibata, Tomoyuki, additional more...

Published
2012
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16. Association between common genetic variant of HRH2 and gastric cancer risk

Author

ARISAWA, TOMIYASU, primary, TAHARA, TOMOMITSU, additional, OZAKI, KAZUAKI, additional, MATSUE, YASUHIRO, additional, MINATO, TAKAHIRO, additional, YAMADA, HIDETO, additional, NOMURA, TOMOE, additional, HAYASHI, RANJI, additional, MATSUNAGA, KAZUHIRO, additional, FUKUMURA, ATSUSHI, additional, NAKAMURA, MASAKATSU, additional, TOSHIKUNI, NOBUYUKI, additional, SHIROEDA, HISAKAZU, additional, and SHIBATA, TOMOYUKI, additional more...

Published
2012
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17. Su1848 The −449c>G Polymorphism of NFKB1 Gene, Coding Nuclear Factor-Kappa-B, is Associated With the Susceptibility to Ulcerative Colitis

Author

Arisawa, Tomiyasu, primary, Tahara, Tomomitsu, additional, Shiroeda, Hisakazu, additional, Minato, Takahiro, additional, Matsue, Yasuhiro, additional, Hayashi, Ranji, additional, Saito, Takashi, additional, Fukuyama, Tomoki, additional, Hayashi, Nobuhiko, additional, Matsunaga, Kazuhiro, additional, Otsuka, Toshimi, additional, Fukumura, Atsushi, additional, Ozaki, Kazuaki, additional, Nakamura, Masakatsu, additional, Toshikuni, Nobuyuki, additional, Tsuchishima, Mutsumi, additional, and Tsutsumi, Mikihiro, additional more...

Published
2012
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18. Su1845 Effects of −1018 G>a Polymorphism of HRH2 Gene, Coding Histamine H2 Receptor, on Hypermethylation of CDH1 Gene in Human Gastric Mucosa

Author

Shiroeda, Hisakazu, primary, Tahara, Tomomitsu, additional, Hayashi, Ranji, additional, Minato, Takahiro, additional, Matsue, Yasuhiro, additional, Yamada, Hideto, additional, Nomura, Tomoe, additional, Saito, Takashi, additional, Matsunaga, Kazuhiro, additional, Hayashi, Nobuhiko, additional, Otsuka, Toshimi, additional, Fukumura, Atsushi, additional, Ozaki, Kazuaki, additional, Toshikuni, Nobuyuki, additional, Tsuchishima, Mutsumi, additional, Tsutsumi, Mikihiro, additional, and Arisawa, Tomiyasu, additional more...

Published
2012
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19. Su1844 The *910t>C Polymorphism of Mafk Gene is Closely Associated With the Progression of Chronic Gastritis

Author

Hayashi, Ranji, primary, Tahara, Tomomitsu, additional, Shiroeda, Hisakazu, additional, Minato, Takahiro, additional, Matsue, Yasuhiro, additional, Yamada, Hideto, additional, Nomura, Tomoe, additional, Saito, Takashi, additional, Matsunaga, Kazuhiro, additional, Hayashi, Nobuhiko, additional, Otsuka, Toshimi, additional, Fukumura, Atsushi, additional, Ozaki, Kazuaki, additional, Toshikuni, Nobuyuki, additional, Tsuchishima, Mutsumi, additional, Tsutsumi, Mikihiro, additional, and Arisawa, Tomiyasu, additional more...

Published
2012
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21. Su1848 The -449c>G Polymorphism of NFKB1 Gene, Coding Nuclear Factor-Kappa-B, is Associated With the Susceptibility to Ulcerative Colitis.

Author

Arisawa, Tomiyasu, Tahara, Tomomitsu, Shiroeda, Hisakazu, Minato, Takahiro, Matsue, Yasuhiro, Hayashi, Ranji, Saito, Takashi, Fukuyama, Tomoki, Hayashi, Nobuhiko, Matsunaga, Kazuhiro, Otsuka, Toshimi, Fukumura, Atsushi, Ozaki, Kazuaki, Nakamura, Masakatsu, Toshikuni, Nobuyuki, Tsuchishima, Mutsumi, and Tsutsumi, Mikihiro more...

Published
2012
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22. Su1845 Effects of -1018 G>a Polymorphism of HRH2 Gene, Coding Histamine H2 Receptor, on Hypermethylation of CDH1 Gene in Human Gastric Mucosa.

Author

Shiroeda, Hisakazu, Tahara, Tomomitsu, Hayashi, Ranji, Minato, Takahiro, Matsue, Yasuhiro, Yamada, Hideto, Nomura, Tomoe, Saito, Takashi, Matsunaga, Kazuhiro, Hayashi, Nobuhiko, Otsuka, Toshimi, Fukumura, Atsushi, Ozaki, Kazuaki, Toshikuni, Nobuyuki, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro, and Arisawa, Tomiyasu more...

Published
2012
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23. Association of Genetic Polymorphisms in IL17A and IL17F with Gastro-Duodenal Diseases.

Author

Hayashi, Ranji, Tahara, Tomomitsu, Shiroeda, Hisakazu, Matsue, Yasuhiro, Minato, Takahiro, Nomura, Tomoe, Yaniada, Hideto, Saito, Takashi, Matsunaga, Kazuhiro, Fukuyama, Tomoki, Hayashi, Nobuhiko, Otsuka, Toshinii, Fukumura, Atsushi, Nakamura, Masakastu, Tsutsumi, Mikihiro, Shibata, Tonioyuki, and Arisawa, Tomiyasu more...

Subjects
*GENETIC polymorphisms, *HELICOBACTER pylori, *DUODENAL diseases, *PEPTIC ulcer, *ATROPHY, *ASPIRIN
Abstract

Background & Aim: The important role of IL-17 in inflammatory response to Helicobacter pylori (H. pylori) colonization has been indicated. We investigated the associations between gastro-duodenal diseases and polymorphisms of IL17A (rs2275913 G>A) and IL17F (rs763780 T>C). Methods: The study was performed in 548 subjects (363 controls and 185 peptic ulcer cases). The multiplex PCR-SSCP method was used to detect gene polymorphisms. Results: Overall, number of rs2275913 A allele was significantly associated with an increased risk for peptic ulcer (OR, 1.50; 95%CI, 1.11-2.01; p=0.0082). The frequency of rs2275913 GA+AA genotype was also significantly higher in ulcer cases than controls (OR, 1.72; 95%CI, 1.09-2.72; p=0.020). The rs2275913 GA+AA genotype conferred an increased risk for the severity of gastric mucosal atrophy in subjects younger than 60 years (OR, 2.83; 95%CI, 1.14-7.04; p=0.025). Both atrophy and metaplasia were increased with age in rs2275913 GA+AA genotype. In NSAIDs/aspirin users, number of rs2275913 A allele was associated with an increased risk for a peptic ulcer (OR, 3.98; 95%CI, 1.48-10.7; p=0.0061). There was no association of rs763780 with the development of peptic ulcer. Conclusions: Our results provide the evidence that rs2275913 is associated with an increased risk for peptic ulcer and the severity of the gastric mucosal atrophy in comparatively younger subjects. In addition, this allele is also associated with the increased risk for peptic ulcer in NSAIDs/aspirin users. [ABSTRACT FROM AUTHOR] more...

Published
2012