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7. The Muscle Thickness Assessment Using Ultrasonography is a Useful Alternative to Skeletal Muscle Mass by Bioelectrical Impedance Analysis

Author

Isaka, Masaaki, primary, Sugimoto, Ken, additional, Akasaka, Hiroshi, additional, Yasunobe, Yukiko, additional, Takahashi, Toshimasa, additional, Xie, Keyu, additional, Onishi, Yuri, additional, Yoshida, Shino, additional, Minami, Tomohiro, additional, Yamamoto, Koichi, additional, Kamide, Kei, additional, and Rakugi, Hiromi, additional

Published
2022
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8. Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo‐controlled , double‐blind study

Author

Akasaka, Hiroshi, primary, Nakagami, Hironori, additional, Sugimoto, Ken, additional, Yasunobe, Yukiko, additional, Minami, Tomohiro, additional, Fujimoto, Taku, additional, Yamamoto, Koichi, additional, Hara, Chikako, additional, Shiraki, Akihiko, additional, Nishida, Kohji, additional, Asano, Kento, additional, Kanou, Masanobu, additional, Yamana, Kei, additional, Imai, Shin‐ichiro, additional, and Rakugi, Hiromi, additional

Published
2022
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10. The Muscle Thickness Assessment Using Ultrasonography is a Useful Alternative to Skeletal Muscle Mass by Bioelectrical Impedance Analysis

Author

Isaka,Masaaki, Sugimoto,Ken, Akasaka,Hiroshi, Yasunobe,Yukiko, Takahashi,Toshimasa, Xie,Keyu, Onishi,Yuri, Yoshida,Shino, Minami,Tomohiro, Yamamoto,Koichi, Kamide,Kei, Rakugi,Hiromi, Isaka,Masaaki, Sugimoto,Ken, Akasaka,Hiroshi, Yasunobe,Yukiko, Takahashi,Toshimasa, Xie,Keyu, Onishi,Yuri, Yoshida,Shino, Minami,Tomohiro, Yamamoto,Koichi, Kamide,Kei, and Rakugi,Hiromi

Abstract

Masaaki Isaka,1– 3 Ken Sugimoto,1,4 Hiroshi Akasaka,1 Yukiko Yasunobe,1 Toshimasa Takahashi,1 Keyu Xie,1 Yuri Onishi,1 Shino Yoshida,1 Tomohiro Minami,1 Koichi Yamamoto,1 Kei Kamide,1,2 Hiromi Rakugi1 1Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 2Department of Health Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 3Physical Therapy, Osaka Yukioka College of Health Science, Ibaraki, Osaka, Japan; 4Department of General Geriatric Medicine, Kawasaki Medical School, Okayama, Okayama, JapanCorrespondence: Ken Sugimoto, Department of General Geriatric Medicine, Kawasaki Medical School, 2-6-1, Nakasange, Kita-ku, Okayama, Okayama, 700-8505, Japan, Tel +81 86 225 2111, Fax +81 86 232 8343, Email ksugimoto@med.kawasaki-m.ac.jpPurpose: Muscle mass, a key index for the diagnosis of sarcopenia, is currently assessed using the appendicular skeletal muscle mass index (ASMI) by bioelectrical impedance analysis (BIA). Muscle thickness (MT) assessed by ultrasonography (US) may be a better determinant and/or predictor of muscle condition than ASMI. Thus, we compared it to the ASMI determined by the BIA.Patients and Methods: Our study included 165 ambulatory older adults (84 males, 81 females, mean age: 76.82 years). The ASMI by the BIA method, MT by US, and the distribution of body mass index (BMI) and body fat percentage (BFP) were examined using defined values for men and women. These were used as the basis for examining the association of MT and ASMI with handgrip strength (HGS), leg muscle strength (LMS), gait speed (GS), and echo intensity (EI). We compared HGS, LMS, GS, and EI for high and low ASMI among lower BMI or BFP. The same was also done for MT assessed by US.Results: MT, as well as ASMI, was strongly associated with HGS and LMS. There was a correlation between MT and GS and EI but not between ASMI and GS and EI. There were significant differences in the prevalence between

Published
2022

11. Interleukin‐15 receptor subunit alpha regulates interleukin‐15 localization and protein expression in skeletal muscle cells

Author

Yoshida, Shino, primary, Fujimoto, Taku, additional, Takahashi, Toshimasa, additional, Sugimoto, Ken, additional, Akasaka, Hiroshi, additional, Tanaka, Minoru, additional, Huang, Yibin, additional, Yasunobe, Yukiko, additional, Xie, Keyu, additional, Ohnishi, Yuri, additional, Minami, Tomohiro, additional, Takami, Yoichi, additional, Yamamoto, Koichi, additional, and Rakugi, Hiromi, additional

Published
2022
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12. Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo‐controlled, double‐blind study.

Author

Akasaka, Hiroshi, Nakagami, Hironori, Sugimoto, Ken, Yasunobe, Yukiko, Minami, Tomohiro, Fujimoto, Taku, Yamamoto, Koichi, Hara, Chikako, Shiraki, Akihiko, Nishida, Kohji, Asano, Kento, Kanou, Masanobu, Yamana, Kei, Imai, Shin‐ichiro, and Rakugi, Hiromi

Subjects
MUSCULOSKELETAL system diseases, GRIP strength, WALKING speed, CONFIDENCE intervals, FUNCTIONAL status, ORAL drug administration, TIME, DIABETES, NUCLEOTIDES, DIETARY supplements, PLACEBOS, BODY movement, BLIND experiment, DESCRIPTIVE statistics, DATA analysis software, LONGITUDINAL method, PATIENT safety, OLD age
Abstract

Objective: Nicotinamide adenine dinucleotide regulates various biological processes. Nicotinamide mononucleotide (NMN) increases its intracellular levels and counteracts age‐associated changes in animal models. We investigated the safety and efficacy of oral nicotinamide mononucleotide supplementation in older patients with diabetes and impaired physical performance. Method: We carried out a 24‐week placebo‐controlled, double‐blinded study of male patients with diabetes aged ≥65 years with reduced grip strength (<26 kg) or walking speed (<1.0 m/s). The primary end‐points were to determine the safety of NMN oral administration (250 mg/day), and changes in grip strength and walking speed. The secondary end‐points were to determine the changes in various exploratory indicators. Results: We studied 14 participants aged 81.1 ± 6.4 years. NMN was tolerable without any severe adverse events. The changes in grip strength and walking speed showed no difference between the two groups: 1.25 kg (95% confidence interval −2.31 to 4.81) and 0.033 m/s (−0.021 to 0.087) in the NMN group, and −0.44 kg (−4.15 to 3.26) and 0.014 m/s (−0.16 to −0.13) in the placebo group, respectively. There were no significant differences in any exploratory indicators between the two groups. However, improved prevalence of frailty in the NMN group (P = 0.066) and different changes in central retinal thickness between the two groups (P = 0.051) was observed. Conclusion: In older male patients with diabetes and impaired physical performance, NMN supplementation for 24 weeks was safe, but did not improve grip strength and walking speed. Geriatr Gerontol Int 2023; 23: 38–43. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Two Cases of the MYH9 Disorder Fechtner Syndrome Diagnosed from Observation of Peripheral Blood Cells before End-Stage Renal Failure

Author

Teshirogi, Shin, primary, Muratsu, Jun, additional, Kasahara, Hidenori, additional, Terashima, Ken, additional, Miki, Sho, additional, Minami, Tomohiro, additional, Okute, Yujiro, additional, Yoneda, Suguru, additional, Morishima, Atsuyuki, additional, Kunishima, Shinji, additional, and Sakaguchi, Katsuhiko, additional

Published
2019
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16. Lenvatinib as an Initial Treatment in Patients with Intermediate-Stage Hepatocellular Carcinoma Beyond Up-To-Seven Criteria and Child–Pugh A Liver Function: A Proof-Of-Concept Study

Author

Kudo, Masatoshi, primary, Ueshima, Kazuomi, additional, Chan, Stephan, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Aoki, Tomoko, additional, Takita, Masahiro, additional, Hagiwara, Satoru, additional, Minami, Yasunori, additional, Ida, Hiroshi, additional, Takenaka, Mamoru, additional, Sakurai, Toshiharu, additional, Watanabe, Tomohiro, additional, Morita, Masahiro, additional, Ogawa, Chikara, additional, Wada, Yoshiyuki, additional, Ikeda, Masafumi, additional, Ishii, Hiroshi, additional, Izumi, Namiki, additional, and Nishida, Naoshi, additional

Published
2019
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17. Impact of Baseline ALBI Grade on the Outcomes of Hepatocellular Carcinoma Patients Treated with Lenvatinib: A Multicenter Study

Author

Ueshima, Kazuomi, primary, Nishida, Naoshi, additional, Hagiwara, Satoru, additional, Aoki, Tomoko, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Takita, Masahiro, additional, Minami, Yasunori, additional, Ida, Hiroshi, additional, Takenaka, Mamoru, additional, Sakurai, Toshiharu, additional, Watanabe, Tomohiro, additional, Morita, Masahiro, additional, Ogawa, Chikara, additional, Hiraoka, Atsushi, additional, Johnson, Philip, additional, and Kudo, Masatoshi, additional

Published
2019
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18. Radiofrequency ablation for hepatocellular carcinoma: Clinical value of ultrasound–ultrasound overlay fusion for optimal ablation and local controllability.

Author

Minami, Yasunori, Minami, Tomohiro, Takita, Masahiro, Hagiwara, Satoru, Ida, Hiroshi, Ueshima, Kazuomi, Nishida, Naoshi, and Kudo, Masatoshi

Subjects
*CATHETER ablation, *HEPATOCELLULAR carcinoma, *CONTROLLABILITY in systems engineering, *CANCER invasiveness, *LOG-rank test, *ENDORECTAL ultrasonography, *SPINAL fusion
Abstract

Aim: To retrospectively investigate the potential benefit of ultrasound–ultrasound (US‐US) overlay fusion guidance for local controllability of radiofrequency ablation (RFA) in the treatment of hepatocellular carcinoma (HCC). Methods: Patients (n = 101) with 121 HCCs (mean ± SD, 1.8 ± 0.7 cm) who underwent RFA guided by US‐US overlay fusion were included in the retrospective study. By overlaying pre/postoperative US, the tumor image could be projected onto the ablative hyperechoic zone. The ablative margin could thereby be evaluated three‐dimensionally during the RFA procedure. As a control group, all 325 patients with 453 HCCs who underwent conventional RFA during the same study period were selected. Results: The total number of RF needle insertions per tumor for ablation was significantly more in the US overlay fusion group (mean 1.9 vs. 1.2; P < 0.01). The technical success rates of ablation after a single session were 100% (101/101) and 96.6% (314/325) for the US overlay fusion group and the control group, respectively. For early assessment of RFA response, 5‐mm safety margins were achieved in 89.3% (108/121) and 47.0% (213/453) of nodules in the US overlay fusion group and the control group, respectively (P < 0.01). During the follow‐up period (median 19 months), the 2‐year local tumor progression rates were 0.8% (1/121) and 6.0% (27/453) in the US overlay fusion group and the control group, respectively (P = 0.022, log–rank test). Conclusions: US‐US overlay fusion guidance can be highly effective for safety margin achievement in RFA for HCC, providing a lower risk of local tumor progression. [ABSTRACT FROM AUTHOR]

Published
2020
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21. Computer-Aided Diagnosis Based on Convolutional Neural Network System for Colorectal Polyp Classification: Preliminary Experience

Author

Komeda, Yoriaki, primary, Handa, Hisashi, additional, Watanabe, Tomohiro, additional, Nomura, Takanobu, additional, Kitahashi, Misaki, additional, Sakurai, Toshiharu, additional, Okamoto, Ayana, additional, Minami, Tomohiro, additional, Kono, Masashi, additional, Arizumi, Tadaaki, additional, Takenaka, Mamoru, additional, Hagiwara, Satoru, additional, Matsui, Shigenaga, additional, Nishida, Naoshi, additional, Kashida, Hiroshi, additional, and Kudo, Masatoshi, additional

Published
2017
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22. The Overall Survival of Patients with Hepatocellular Carcinoma Correlates with the Newly Defined Time to Progression after Transarterial Chemoembolization

Author

Arizumi, Tadaaki, primary, Ueshima, Kazuomi, additional, Iwanishi, Mina, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Kono, Masashi, additional, Takita, Masahiro, additional, Yada, Norihisa, additional, Hagiwara, Satoru, additional, Minami, Yasunori, additional, Ida, Hiroshi, additional, Komeda, Yoriaki, additional, Takenaka, Mamoru, additional, Sakurai, Toshiharu, additional, Watanabe, Tomohiro, additional, Nishida, Naoshi, additional, and Kudo, Masatoshi, additional

Published
2017
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23. Unique Characteristics Associated with Sustained Liver Damage in Chronic Hepatitis C Patients Treated with Direct Acting Antivirals

Author

Kono, Masashi, primary, Nishida, Naoshi, additional, Hagiwara, Satoru, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Arizumi, Tadaaki, additional, Minaga, Kosuke, additional, Kamata, Ken, additional, Komeda, Yoriaki, additional, Sakurai, Toshiharu, additional, Takenaka, Mamoru, additional, Takita, Masahiro, additional, Yada, Norihisa, additional, Ida, Hiroshi, additional, Minami, Yasunori, additional, Ueshima, Kazuomi, additional, Watanabe, Tomohiro, additional, and Kudo, Masatoshi, additional

Published
2017
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24. Hepatocarcinogenesis Is Associated with Serum Albumin Levels after Sustained Virological Responses with Interferon-Based Therapy in Patients with Hepatitis C

Author

Umehara, Yasuko, primary, Hagiwara, Satoru, additional, Nishida, Naoshi, additional, Sakurai, Toshiharu, additional, Ida, Hiroshi, additional, Minami, Yasunori, additional, Takita, Masahiro, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Ueshima, Kazuomi, additional, Komeda, Yoriaki, additional, Arizumi, Tadaaki, additional, Watanabe, Tomohiro, additional, and Kudo, Masatoshi, additional

Published
2017
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26. Hepatocellular Carcinoma after Achievement of Sustained Viral Response with Daclatasvir and Asunaprevir in Patients with Chronic Hepatitis C Virus Infection

Author

Ida, Hiroshi, primary, Hagiwara, Satoru, additional, Kono, Masashi, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Arizumi, Tadaaki, additional, Takita, Masahiro, additional, Yada, Norihisa, additional, Minami, Yasunori, additional, Ueshima, Kazuomi, additional, Nishida, Naoshi, additional, and Kudo, Masatoshi, additional

Published
2017
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27. Time to Transcatheter Arterial Chemoembolization Refractoriness in Patients with Hepatocellular Carcinoma in Kinki Criteria Stages B1 and B2

Author

Arizumi, Tadaaki, primary, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Kono, Masashi, additional, Takita, Masahiro, additional, Yada, Norihisa, additional, Hagiwara, Satoru, additional, Minami, Yasunori, additional, Ida, Hiroshi, additional, Ueshima, Kazuomi, additional, Kamata, Ken, additional, Minaga, Kosuke, additional, Komeda, Yoriaki, additional, Takenaka, Mamoru, additional, Sakurai, Toshiharu, additional, Watanabe, Tomohiro, additional, Nishida, Naoshi, additional, and Kudo, Masatoshi, additional

Published
2017
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28. Impact of Tumor Factors on Survival in Patients with Hepatocellular Carcinoma Classified Based on Kinki Criteria Stage B2

Author

Arizumi, Tadaaki, primary, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Kono, Masashi, additional, Takita, Masahiro, additional, Yada, Norihisa, additional, Hagiwara, Satoru, additional, Minami, Yasunori, additional, Ida, Hiroshi, additional, Ueshima, Kazuomi, additional, Kamata, Ken, additional, Minaga, Kosuke, additional, Komeda, Yoriaki, additional, Takenaka, Mamoru, additional, Sakurai, Toshiharu, additional, Watanabe, Tomohiro, additional, Nishida, Naoshi, additional, and Kudo, Masatoshi, additional

Published
2017
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29. Malignant Transformation of Hepatocellular Adenoma

Author

Kwok, Wing Yee, primary, Hagiwara, Satoru, additional, Nishida, Naoshi, additional, Watanabe, Tomohiro, additional, Sakurai, Toshiharu, additional, Ida, Hiroshi, additional, Minami, Yasunori, additional, Takita, Masahiro, additional, Minami, Tomohiro, additional, Iwanishi, Mina, additional, Chishina, Hirokazu, additional, Kono, Masashi, additional, Ueshima, Kazuomi, additional, Komeda, Yoriaki, additional, Arizumi, Tadaaki, additional, Enoki, Eisuke, additional, Nakai, Takuya, additional, Kumabe, Tsutomu, additional, Nakashima, Osamu, additional, Kondo, Fukuo, additional, and Kudo, Masatoshi, additional

Published
2016
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30. Contrast-Enhanced Tissue Harmonic Imaging versus Phase Inversion Harmonic Sonographic Imaging for the Delineation of Hepatocellular Carcinomas

Author

Kono, Masashi, primary, Minami, Yasunori, additional, Iwanishi, Mina, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Arizumi, Tadaaki, additional, Komeda, Yoriaki, additional, Sakurai, Toshiharu, additional, Takita, Masahiro, additional, Yada, Norihisa, additional, Ida, Hiroshi, additional, Hagiwara, Satoru, additional, Ueshima, Kazuomi, additional, Nishida, Naoshi, additional, and Kudo, Masatoshi, additional

Published
2016
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31. Outcome of Combination Therapy with Sofosbuvir and Ledipasvir for Chronic Type C Liver Disease

Author

Hagiwara, Satoru, primary, Nishida, Naoshi, additional, Watanabe, Tomohiro, additional, Sakurai, Toshiharu, additional, Ida, Hiroshi, additional, Minami, Yasunori, additional, Takita, Masahiro, additional, Minami, Tomohiro, additional, Iwanishi, Mina, additional, Chishina, Hirokazu, additional, Ueshima, Kazuomi, additional, Komeda, Yoriaki, additional, Arizumi, Tadaaki, additional, and Kudo, Masatoshi, additional

Published
2016
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32. Monoethanolamine Oleate Sclerotherapy for Polycystic Liver Disease

Author

Takita, Masahiro, primary, Iwanishi, Mina, additional, Minami, Tomohiro, additional, Kono, Masashi, additional, Chishina, Hirokazo, additional, Arizumi, Tadaaki, additional, Yada, Norihisa, additional, Hagiwara, Satoru, additional, Minami, Yasunori, additional, Ida, Hiroshi, additional, Ueshima, Kazuomi, additional, Naoshi, Nishida, additional, and Kudo, Masatoshi, additional

Published
2016
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33. Outcome of Asunaprevir/Daclatasvir Combination Therapy for Chronic Liver Disease Type C

Author

Hagiwara, Satoru, primary, Nishida, Naoshi, additional, Watanabe, Tomohiro, additional, Sakurai, Toshiharu, additional, Ida, Hiroshi, additional, Minami, Yasunori, additional, Takita, Masahiro, additional, Minami, Tomohiro, additional, Iwanishi, Mina, additional, Chishina, Hirokazu, additional, Ueshima, Kazuomi, additional, Komeda, Yoriaki, additional, Arizumi, Tadaaki, additional, and Kudo, Masatoshi, additional

Published
2016
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34. Validation of Kinki Criteria, a Modified Substaging System, in Patients with Intermediate Stage Hepatocellular Carcinoma

Author

Arizumi, Tadaaki, primary, Ueshima, Kazuomi, additional, Iwanishi, Mina, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Kono, Masashi, additional, Takita, Masahiro, additional, Kitai, Satoshi, additional, Inoue, Tatsuo, additional, Yada, Norihisa, additional, Hagiwara, Satoru, additional, Minami, Yasunori, additional, Ida, Hiroshi, additional, Sakurai, Toshiharu, additional, Kitano, Masayuki, additional, Nishida, Naoshi, additional, and Kudo, Masatoshi, additional

Published
2016
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35. US-US Fusion Imaging in Radiofrequency Ablation for Liver Metastases

Author

Minami, Yasunori, primary, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Kono, Masashi, additional, Arizumi, Tadaaki, additional, Takita, Masahiro, additional, Yada, Norihisa, additional, Hagiwara, Satoru, additional, Ida, Hiroshi, additional, Ueshima, Kazuomi, additional, Nishida, Naoshi, additional, and Kudo, Masatoshi, additional

Published
2016
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37. Safety, Tolerability, and Efficacy of Sofosbuvir Plus Ribavirin in Elderly Patients Infected with Hepatitis C Virus Genotype 2

Author

Nishida, Naoshi, primary, Kono, Masashi, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Arizumi, Tadaaki, additional, Takita, Masahiro, additional, Yada, Norihisa, additional, Ida, Hiroshi, additional, Hagiwara, Satoru, additional, Minami, Yasunori, additional, Ueshima, Kazuomi, additional, Sakurai, Tashiharu, additional, and Kudo, Masatoshi, additional

Published
2016
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39. Clinical Factors Predicting the Effect of Tolvaptan for Refractory Ascites in Patients with Decompensated Liver Cirrhosis

Author

Chishina, Hirokazu, primary, Hagiwara, Satoru, additional, Nishida, Naoshi, additional, Ueshima, Kazuomi, additional, Sakurai, Toshiharu, additional, Ida, Hiroshi, additional, Minami, Yasunori, additional, Takita, Masahiro, additional, Kono, Masashi, additional, Minami, Tomohiro, additional, Iwanishi, Mina, additional, Umehara, Yasuko, additional, Watanabe, Tomohiro, additional, Komeda, Yoriaki, additional, Arizumi, Tadaaki, additional, and Kudo, Masotoshi, additional

Published
2016
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41. Validation of a Modified Substaging System (Kinki Criteria) for Patients with Intermediate-Stage Hepatocellular Carcinoma

Author

Arizumi, Tadaaki, primary, Ueshima, Kazuomi, additional, Iwanishi, Mina, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Kono, Masashi, additional, Takita, Masahiro, additional, Kitai, Satoshi, additional, Inoue, Tatsuo, additional, Yada, Norihisa, additional, Hagiwara, Satoru, additional, Ida, Hiroshi, additional, Minami, Yasunori, additional, Sakurai, Toshiharu, additional, Kitano, Masayuki, additional, Nishida, Naoshi, additional, and Kudo, Masatoshi, additional

Published
2015
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43. Hepatic DNA Methylation Is Affected by Hepatocellular Carcinoma Risk in Patients with and without Hepatitis Virus

Author

Nishida, Naoshi, primary, Iwanishi, Mina, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Arizumi, Tadaaki, additional, Takita, Masahiro, additional, Kitai, Satoshi, additional, Yada, Norihisa, additional, Ida, Hiroshi, additional, Hagiwara, Satoru, additional, Minami, Yasunori, additional, Ueshima, Kazuomi, additional, Sakurai, Toshiharu, additional, Kitano, Masayuki, additional, and Kudo, Masatoshi, additional

Published
2015
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44. Evaluation of ART Scores for Repeated Transarterial Chemoembolization in Japanese Patients with Hepatocellular Carcinoma

Author

Arizumi, Tadaaki, primary, Ueshima, Kazuomi, additional, Iwanishi, Mina, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Kono, Masashi, additional, Takita, Masahiro, additional, Kitai, Satoshi, additional, Inoue, Tatsuo, additional, Yada, Norihisa, additional, Hagiwara, Satoru, additional, Ida, Hiroshi, additional, Minami, Yasunori, additional, Sakurai, Toshiharu, additional, Nishida, Naoshi, additional, Kitano, Masayuki, additional, and Kudo, Masatoshi, additional

Published
2015
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46. Effectiveness of Sorafenib in Patients with Transcatheter Arterial Chemoembolization (TACE) Refractory and Intermediate-Stage Hepatocellular Carcinoma

Author

Arizumi, Tadaaki, primary, Ueshima, Kazuomi, additional, Minami, Tomohiro, additional, Kono, Masashi, additional, Chishina, Hirokazu, additional, Takita, Masahiro, additional, Kitai, Satoshi, additional, Inoue, Tatsuo, additional, Yada, Norihisa, additional, Hagiwara, Satoru, additional, Minami, Yasunori, additional, Sakurai, Toshiharu, additional, Nishida, Naoshi, additional, and Kudo, Masatoshi, additional

Published
2015
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48. Early Viral Response Predicts the Efficacy of Antiviral Triple Therapy with Simeprevir, Peg-Interferon and Ribavirin in Patients Infected with Hepatitis C Virus Genotype 1

Author

Nishida, Naoshi, primary, Iwanishi, Mina, additional, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Arizumi, Tadaaki, additional, Takita, Masahiro, additional, Kitai, Satoshi, additional, Yada, Norihisa, additional, Ida, Hiroshi, additional, Hagiwara, Satoru, additional, Minami, Yasunori, additional, Ueshima, Kazuomi, additional, Sakurai, Toshiharu, additional, Kitano, Masayuki, additional, and Kudo, Masatoshi, additional

Published
2015
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49. Balloon-Occluded Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Single-Center Experience

Author

Minami, Yasunori, primary, Minami, Tomohiro, additional, Chishina, Hirokazu, additional, Arizumi, Tadaaki, additional, Takita, Masahiro, additional, Kitai, Satoshi, additional, Yada, Norihisa, additional, Hagiwara, Satoru, additional, Tsurusaki, Masakatsu, additional, Yagyu, Yukinobu, additional, Ueshima, Kazuomi, additional, Nishida, Naoshi, additional, Murakami, Takamichi, additional, and Kudo, Masatoshi, additional

Published
2015
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50. Contrast-Enhanced Tissue Harmonic Imaging versus Phase Inversion Harmonic Sonographic Imaging for the Delineation of Hepatocellular Carcinomas.

Author

Kono, Masashi, Minami, Yasunori, Iwanishi, Mina, Minami, Tomohiro, Chishina, Hirokazu, Arizumi, Tadaaki, Komeda, Yoriaki, Sakurai, Toshiharu, Takita, Masahiro, Yada, Norihisa, Ida, Hiroshi, Hagiwara, Satoru, Ueshima, Kazuomi, Nishida, Naoshi, and Kudo, Masatoshi

Subjects
COMPARATIVE studies, HEPATOCELLULAR carcinoma, CIRRHOSIS of the liver, COMPUTERS in medicine, PROBABILITY theory, THERAPEUTICS, ULTRASONIC imaging, CONTRAST media, ABLATION techniques, DESCRIPTIVE statistics
Abstract

Objective: To compare contrast tissue harmonic imaging (THI) with low mechanical index (MI) and conventional contrast harmonic imaging (CHI) with respect to lesion visibility of hepatocellular carcinoma (HCC). Methods: One hundred and twenty-five patients (84 men and 41 women, age range 39-94 years, mean age 74 years) with 100 naïve HCCs and 30 lesions after radiofrequency ablation (RFA) for HCC were evaluated. One hundred and four patients had liver cirrhosis of Child-Pugh class A, and the remaining 21 had Child-Pugh class B cirrhosis. The lesion conspicuity and intratumoral echogenicity during the postvascular phase were compared using conventional CHI and contrast THI with low MI. Results: The MI values ranged from 0.20 to 0.30 on convention-al CHI and from 0.30 to 0.35 on contrast THI. Regarding HCC lesion conspicuity, contrast THI with low MI was clearer in 79 lesions (60.8%), equal in 34 lesions (26.2%), and less clear in 17 lesions (13.1%) when compared with conventional CHI. The lesion conspicuity with contrast THI was significantly better than that with conventional CHI (p < 0.01). All of the postablative lesions were well delineated in patients who received RFA. Conclusion: Low-MI contrast THI was superior to conventional CHI with respect to lesion visibility of HCCs and might offer good imaging for the guiding of RFA. [ABSTRACT FROM AUTHOR]

Published
2017
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