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2. Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine

Author

Li, Dapeng, Martinez, David R., Schäfer, Alexandra, Chen, Haiyan, Barr, Maggie, Sutherland, Laura L., Lee, Esther, Parks, Robert, Mielke, Dieter, Edwards, Whitney, Newman, Amanda, Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Gagne, Matthew, Douek, Daniel C., DeMarco, C. Todd, Denny, Thomas N., Oguin, III, Thomas H., Brown, Alecia, Rountree, Wes, Wang, Yunfei, Mansouri, Katayoun, Edwards, Robert J., Ferrari, Guido, Sempowski, Gregory D., Eaton, Amanda, Tang, Juanjie, Cain, Derek W., Santra, Sampa, Pardi, Norbert, Weissman, Drew, Tomai, Mark A., Fox, Christopher B., Moore, Ian N., Andersen, Hanne, Lewis, Mark G., Golding, Hana, Seder, Robert, Khurana, Surender, Baric, Ralph S., Montefiori, David C., Saunders, Kevin O., and Haynes, Barton F.

Published
2022
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4. mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates

Author

Corbett, Kizzmekia S., Werner, Anne P., Connell, Sarah O’, Gagne, Matthew, Lai, Lilin, Moliva, Juan I., Flynn, Barbara, Choi, Angela, Koch, Matthew, Foulds, Kathryn E., Andrew, Shayne F., Flebbe, Dillon R., Lamb, Evan, Nurmukhambetova, Saule T., Provost, Samantha J., Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Ry, Alex Van, Flinchbaugh, Zackery, Johnston, Timothy S., Mokhtari, Elham Bayat, Mudvari, Prakriti, Henry, Amy R., Laboune, Farida, Chang, Becky, Porto, Maciel, Wear, Jaclyn, Alvarado, Gabriela S., Boyoglu-Barnum, Seyhan, Todd, John-Paul M., Bart, Bridget, Cook, Anthony, Dodson, Alan, Pessaint, Laurent, Steingrebe, Katelyn, Elbashir, Sayda, Sriparna, Manjari, Pekosz, Andrew, Andersen, Hanne, Wu, Kai, Edwards, Darin K., Kar, Swagata, Lewis, Mark G., Boritz, Eli, Moore, Ian N., Carfi, Andrea, Suthar, Mehul S., McDermott, Adrian, Roederer, Mario, Nason, Martha C., Sullivan, Nancy J., Douek, Daniel C., Graham, Barney S., and Seder, Robert A.

Published
2021
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5. Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses

Author

Saunders, Kevin O., Lee, Esther, Parks, Robert, Martinez, David R., Li, Dapeng, Chen, Haiyan, Edwards, Robert J., Gobeil, Sophie, Barr, Maggie, Mansouri, Katayoun, Alam, S. Munir, Sutherland, Laura L., Cai, Fangping, Sanzone, Aja M., Berry, Madison, Manne, Kartik, Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Kapingidza, Anyway B., Azoitei, Mihai, Tse, Longping V., Scobey, Trevor D., Spreng, Rachel L., Rountree, R. Wes, DeMarco, C. Todd, Denny, Thomas N., Woods, Christopher W., Petzold, Elizabeth W., Tang, Juanjie, Oguin, III, Thomas H., Sempowski, Gregory D., Gagne, Matthew, Douek, Daniel C., Tomai, Mark A., Fox, Christopher B., Seder, Robert, Wiehe, Kevin, Weissman, Drew, Pardi, Norbert, Golding, Hana, Khurana, Surender, Acharya, Priyamvada, Andersen, Hanne, Lewis, Mark G., Moore, Ian N., Montefiori, David C., Baric, Ralph S., and Haynes, Barton F.

Published
2021
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7. Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Author

Malewana, R. Dilshan, primary, Stalls, Victoria, additional, May, Aaron, additional, Lu, Xiaozhi, additional, Martinez, David R, additional, Schafer, Alexandra, additional, Li, Dapeng, additional, Barr, Maggie, additional, Sutherland, Laura L, additional, Lee, Esther, additional, Parks, Robert, additional, Beck, Whitney Edwards, additional, Newman, Amanda, additional, Bock, Kevin W, additional, Minai, Mahnaz, additional, Nagata, Bianca M, additional, DeMarco, C. Todd, additional, Denny, Thomas N, additional, Oguin, Thomas H, additional, Rountree, Wes, additional, Wang, Yunfei, additional, Mansouri, Katayoun, additional, Edwards, Robert J, additional, Sempowski, Gregory D, additional, Eaton, Amanda, additional, Muramatsu, Hiromi, additional, Henderson, Rory, additional, Tam, Ying, additional, Barbosa, Christopher, additional, Tang, Juanjie, additional, Cain, Derek W, additional, Santra, Sampa, additional, Moore, Ian N, additional, Andersen, Hanne, additional, Lewis, Mark G, additional, Golding, Hana, additional, Seder, Robert, additional, Khurana, Surender, additional, Montefiori, David C, additional, Pardi, Norbert, additional, Weissman, Drew, additional, Baric, Ralph S, additional, Acharya, Priyamvada, additional, Haynes, Barton F, additional, and Saunders, Kevin O, additional

Published
2023
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9. Durable immunity to SARS-CoV-2 in both lower and upper airways achieved with a gorilla adenovirus (GRAd) S-2P vaccine in non-human primates

Author

Moliva, Juan I, primary, Andrew, Shayne F, additional, Flynn, Barbara J, additional, Wagner, Danielle A, additional, Foulds, Kathryn E, additional, Gagne, Matthew, additional, Flebbe, Dillon R, additional, Lamb, Evan, additional, Provost, Samantha, additional, Marquez, Josue, additional, Mychalowych, Anna, additional, Lorag, Cynthia, additional, Honeycutt, Christopher Cole, additional, Burnett, Matthew R, additional, McCormick, Lauren, additional, Henry, Amy R, additional, Godbole, Sucheta, additional, Davis-Gardner, Meredith E, additional, Minai, Mahnaz, additional, Bok, Kevin W, additional, Nagata, Bianca M, additional, Todd, John-Paul M, additional, McCarthy, Elizabeth, additional, Dodson, Alan, additional, Kouneski, Katelyn, additional, Cook, Anthony, additional, Pessaint, Laurent, additional, Van Ry, Alex, additional, Valentin, Daniel, additional, Young, Steve, additional, Littman, Yoav, additional, Boon, Adrianus C. M., additional, Suthar, Mehul S, additional, Lewis, Mark G, additional, Andersen, Hanne, additional, Alves, Derron A, additional, Woodward, Ruth, additional, Leuzzi, Adriano, additional, Vitelli, Alessandra, additional, Colloca, Stefano, additional, Folgori, Antonella, additional, Raggiolli, Angelo, additional, Capone, Stefania, additional, Nason, Martha C, additional, Douek, Daniel, additional, Roederer, Mario, additional, Seder, Robert A, additional, and Sullivan, Nancy J, additional

Published
2023
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10. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

Author

Corbett, Kizzmekia S., Edwards, Darin K., Leist, Sarah R., Abiona, Olubukola M., Boyoglu-Barnum, Seyhan, Gillespie, Rebecca A., Himansu, Sunny, Schäfer, Alexandra, Ziwawo, Cynthia T., DiPiazza, Anthony T., Dinnon, Kenneth H., Elbashir, Sayda M., Shaw, Christine A., Woods, Angela, Fritch, Ethan J., Martinez, David R., Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Hutchinson, Geoffrey B., Wu, Kai, Henry, Carole, Bahl, Kapil, Garcia-Dominguez, Dario, Ma, LingZhi, Renzi, Isabella, Kong, Wing-Pui, Schmidt, Stephen D., Wang, Lingshu, Zhang, Yi, Phung, Emily, Chang, Lauren A., Loomis, Rebecca J., Altaras, Nedim Emil, Narayanan, Elisabeth, Metkar, Mihir, Presnyak, Vlad, Liu, Cuiping, Louder, Mark K., Shi, Wei, Leung, Kwanyee, Yang, Eun Sung, West, Ande, Gully, Kendra L., Stevens, Laura J., Wang, Nianshuang, Wrapp, Daniel, Doria-Rose, Nicole A., Stewart-Jones, Guillaume, Bennett, Hamilton, Alvarado, Gabriela S., Nason, Martha C., Ruckwardt, Tracy J., McLellan, Jason S., Denison, Mark R., Chappell, James D., Moore, Ian N., Morabito, Kaitlyn M., Mascola, John R., Baric, Ralph S., Carfi, Andrea, and Graham, Barney S.

Published
2020
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11. Pathogenesis and outcome of VA1 astrovirus infection in the human brain are defined by disruption of neural functions and imbalanced host immune responses

Author

Maximova, Olga A., primary, Weller, Melodie L., additional, Krogmann, Tammy, additional, Sturdevant, Daniel E., additional, Ricklefs, Stacy, additional, Virtaneva, Kimmo, additional, Martens, Craig, additional, Wollenberg, Kurt, additional, Minai, Mahnaz, additional, Moore, Ian N., additional, Sauter, Craig S., additional, Barker, Juliet N., additional, Lipkin, W. Ian, additional, Seilhean, Danielle, additional, Nath, Avindra, additional, and Cohen, Jeffrey I., additional

Published
2023
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12. Attenuated activation of pulmonary immune cells in mRNA-1273-vaccinated hamsters after SARS-CoV-2 infection

Author

Meyer, Michelle, Wang, Yuan, Edwards, Darin, Smith, Gregory R., Rubenstein, Aliza B., Ramanathan, Palaniappan, Mire, Chad E., Pietzsch, Colette, Chen, Xi, Ge, Yongchao, Cheng, Wan Sze, Henry, Carole, Woods, Angela, Ma, LingZhi, Stewart-Jones, Guillaume B.E., Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Periasamy, Sivakumar, Shi, Pei-Yong, Graham, Barney S., Moore, Ian N., Ramos, Irene, Troyanskaya, Olga G., Zaslavsky, Elena, Carfi, Andrea, Sealfon, Stuart C., and Bukreyev, Alexander

Subjects
Immunological research, Lung diseases -- Models -- Development and progression -- Prevention, Immune response -- Research, Messenger RNA -- Health aspects -- Physiological aspects, Leukocytes -- Health aspects -- Physiological aspects, Hamsters -- Physiological aspects, Health care industry
Abstract

The mRNA-1273 vaccine is effective against SARS-CoV-2 and was granted emergency use authorization by the FDA. Clinical studies, however, cannot provide the controlled response to infection and complex immunological insight that are only possible with preclinical studies. Hamsters are the only model that reliably exhibits severe SARS-CoV-2 disease similar to that in hospitalized patients, making them pertinent for vaccine evaluation. We demonstrate that prime or prime-boost administration of mRNA-1273 in hamsters elicited robust neutralizing antibodies, ameliorated weight loss, suppressed SARS-CoV-2 replication in the airways, and better protected against disease at the highest prime-boost dose. Unlike in mice and nonhuman primates, low-level virus replication in mRNA-1273-vaccinated hamsters coincided with an anamnestic response. Single-cell RNA sequencing of lung tissue permitted high-resolution analysis that is not possible in vaccinated humans. mRNA-1273 prevented inflammatory cell infiltration and the reduction of lymphocyte proportions, but enabled antiviral responses conducive to lung homeostasis. Surprisingly, infection triggered transcriptome programs in some types of immune cells from vaccinated hamsters that were shared, albeit attenuated, with mock- vaccinated hamsters. Our results support the use of mRNA-1273 in a 2-dose schedule and provide insight into the potential responses within the lungs of vaccinated humans who are exposed to SARS-CoV-2., Introduction When the World Health Organization declared severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a global pandemic in March 2020, phase I clinical trials on the most promising vaccine candidates [...]

Published
2021
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13. Atypical Chemokine Receptor 1 (Ackr1)-deficient Mice Resist Lethal SARS-CoV-2 Challenge

Author

Majumdar, Shamik, primary, Weaver, Joseph D., additional, Pontejo, Sergio M., additional, Minai, Mahnaz, additional, Georgia-Clark, Shalamar, additional, Gao, Ji-Liang, additional, Lu, Xinping, additional, Zhang, Hongwei, additional, Lackemeyer, Nicole, additional, Burdette, Tracey, additional, Johnson, Reed, additional, Kelsall, Brian L., additional, Farber, Joshua M., additional, Alves, Derron A., additional, and Murphy, Philip M., additional

Published
2023
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14. Anophelessalivary apyrase regulates blood meal hemostasis and drives malaria parasite transmission

Author

Pala, Zarna Rajeshkumar, primary, Alves e Silva, Thiago Luiz, additional, Minai, Mahnaz, additional, Crews, Benjamin, additional, Patino-Martinez, Eduardo, additional, Carmona-Rivera, Carmelo, additional, Valenzuela-Leon, Paola Carolina, additional, Martin-Martin, Ines, additional, Flores-Garcia, Yevel, additional, Cachau, Raul Eduardo, additional, Srivastava, Naman, additional, Moore, Ian N, additional, Alves, Derron A, additional, Kaplan, Mariana J, additional, Fischer, Elizabeth, additional, Calvo, Eric, additional, and Vega-Rodriguez, Joel, additional

Published
2023
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15. Prolonging culture of primary human keratinocytes isolated from suction blisters with the Rho kinase inhibitor Y-27632.

Author

Erik D Anderson, Inka Sastalla, Noah J Earland, Minai Mahnaz, Ian N Moore, Francisco Otaizo-Carrasquero, Timothy G Myers, Christopher A Myles, Sandip K Datta, and Ian A Myles

Subjects
Medicine, Science
Abstract

Keratinocytes are the most abundant cell type in the epidermis. They prevent desiccation and provide immunological and barrier defense against potential pathogens such as Staphylococcus aureus and Candida albicans. The study of this first line of immune defense may be hindered by invasive isolation methods and/or improper culture conditions to support stem cell maintenance and other potential mechanisms contributing to long-term subcultivation in vitro. Primary keratinocytes have been successfully isolated from blister roofs induced by negative pressure, which separates the epidermis from the dermis in vivo in human subjects. This method allows collection of pure epidermal cells without dermal contamination in a minimally invasive manner. However, the isolated keratinocytes differentiate and senesce when cultured in vitro beyond five passages. Here, we present evidence that the Rho kinase (ROCK) inhibitor Y-27632 can be used to effectively increase the proliferative capabilities of keratinocytes isolated using the suction blister method, similar to what has been previously reported for primary keratinocytes isolated using alternative methods. We show that the increase in passage number is directly correlated to delayed differentiation, and that cells passaged long term with the inhibitor retain their ability to stratify in organotypic raft cultures and respond to cytokine treatment; additionally, the late passage cells have a heterogeneous mix of differentiated and non-differentiated cells which may be predicted by a ratio of select differentiation markers. The described method presents a minimally invasive procedure for keratinocyte isolation and prolonged culture that allows analysis of keratinocyte function in both healthy volunteers and patients with dermatologic diseases.

Published
2018
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16. Imbalanced immune response and dysregulation of neural functions underline fatal opportunistic encephalitis caused by astrovirus

Author

Maximova, Olga A., primary, Weller, Melodie L., additional, Krogmann, Tammy, additional, Sturdevant, Daniel E., additional, Ricklefs, Stacy, additional, Virtaneva, Kimmo, additional, Martens, Craig, additional, Wollenberg, Kurt, additional, Minai, Mahnaz, additional, Moore, Ian N., additional, Sauter, Craig S., additional, Barker, Juliet N., additional, Lipkin, W. Ian, additional, Seilhean, Danielle, additional, Nath, Avindra, additional, and Cohen, Jeffrey I., additional

Published
2022
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17. The soft palate is an important site of adaptation for transmissible influenza viruses

Author

Lakdawala, Seema S., Jayaraman, Akila, Halpin, Rebecca A., Lamirande, Elaine W., Shih, Angela R., Stockwell, Timothy B., Lin, Xudong, Simenauer, Ari, Hanson, Christopher T., Vogel, Leatrice, Paskel, Myeisha, Minai, Mahnaz, Moore, Ian, Orandle, Marlene, Das, Suman R., Wentworth, David E., Sasisekharan, Ram, and Subbarao, Kanta

Subjects
Palate, Influenza viruses, Disease transmission, Host-virus relationships, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Influenza A viruses pose a major public health threat by causing seasonal epidemics and sporadic pandemics. Their epidemiological success relies on airborne transmission from person to person; however, the viral [...]

Published
2015

18. An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant replication in rhesus macaques

Author

Sui, Yongjun, primary, Li, Jianping, additional, Andersen, Hanne, additional, Zhang, Roushu, additional, Prabhu, Sunaina K, additional, Hoang, Tanya, additional, Venzon, David, additional, Cook, Anthony, additional, Brown, Renita, additional, Teow, Elyse, additional, Velasco, Jason, additional, Pessaint, Laurent, additional, Moore, Ian N, additional, Lagenaur, Laurel, additional, Talton, Jim, additional, Breed, Matthew W, additional, Kramer, Josh, additional, Bock, Kevin W, additional, Minai, Mahnaz, additional, Nagata, Bianca M, additional, Choo-Wosoba, Hyoyoung, additional, Lewis, Mark G, additional, Wang, Lai-Xi, additional, and Berzofsky, Jay A, additional

Published
2022
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19. mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

Author

Gagne, Matthew, primary, Moliva, Juan I., additional, Foulds, Kathryn E., additional, Andrew, Shayne F., additional, Flynn, Barbara J., additional, Werner, Anne P., additional, Wagner, Danielle A., additional, Teng, I-Ting, additional, Lin, Bob C., additional, Moore, Christopher, additional, Jean-Baptiste, Nazaire, additional, Carroll, Robin, additional, Foster, Stephanie L., additional, Patel, Mit, additional, Ellis, Madison, additional, Edara, Venkata-Viswanadh, additional, Maldonado, Nahara Vargas, additional, Minai, Mahnaz, additional, McCormick, Lauren, additional, Honeycutt, Christopher Cole, additional, Nagata, Bianca M., additional, Bock, Kevin W., additional, Dulan, Caitlyn N.M., additional, Cordon, Jamilet, additional, Flebbe, Dillon R., additional, Todd, John-Paul M., additional, McCarthy, Elizabeth, additional, Pessaint, Laurent, additional, Van Ry, Alex, additional, Narvaez, Brandon, additional, Valentin, Daniel, additional, Cook, Anthony, additional, Dodson, Alan, additional, Steingrebe, Katelyn, additional, Nurmukhambetova, Saule T., additional, Godbole, Sucheta, additional, Henry, Amy R., additional, Laboune, Farida, additional, Roberts-Torres, Jesmine, additional, Lorang, Cynthia G., additional, Amin, Shivani, additional, Trost, Jessica, additional, Naisan, Mursal, additional, Basappa, Manjula, additional, Willis, Jacquelyn, additional, Wang, Lingshu, additional, Shi, Wei, additional, Doria-Rose, Nicole A., additional, Zhang, Yi, additional, Yang, Eun Sung, additional, Leung, Kwanyee, additional, O’Dell, Sijy, additional, Schmidt, Stephen D., additional, Olia, Adam S., additional, Liu, Cuiping, additional, Harris, Darcy R., additional, Chuang, Gwo-Yu, additional, Stewart-Jones, Guillaume, additional, Renzi, Isabella, additional, Lai, Yen-Ting, additional, Malinowski, Agata, additional, Wu, Kai, additional, Mascola, John R., additional, Carfi, Andrea, additional, Kwong, Peter D., additional, Edwards, Darin K., additional, Lewis, Mark G., additional, Andersen, Hanne, additional, Corbett, Kizzmekia S., additional, Nason, Martha C., additional, McDermott, Adrian B., additional, Suthar, Mehul S., additional, Moore, Ian N., additional, Roederer, Mario, additional, Sullivan, Nancy J., additional, Douek, Daniel C., additional, and Seder, Robert A., additional

Published
2022
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20. mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron

Author

Gagne, Matthew, primary, Moliva, Juan I., additional, Foulds, Kathryn E., additional, Andrew, Shayne F., additional, Flynn, Barbara J., additional, Werner, Anne P., additional, Wagner, Danielle A., additional, Teng, I-Ting, additional, Lin, Bob C., additional, Moore, Christopher, additional, Jean-Baptiste, Nazaire, additional, Carroll, Robin, additional, Foster, Stephanie L., additional, Patel, Mit, additional, Ellis, Madison, additional, Edara, Venkata-Viswanadh, additional, Maldonado, Nahara Vargas, additional, Minai, Mahnaz, additional, McCormick, Lauren, additional, Honeycutt, Christopher Cole, additional, Nagata, Bianca M., additional, Bock, Kevin W., additional, Dulan, Caitlyn N. M., additional, Cordon, Jamilet, additional, Todd, John-Paul M., additional, McCarthy, Elizabeth, additional, Pessaint, Laurent, additional, Van Ry, Alex, additional, Narvaez, Brandon, additional, Valentin, Daniel, additional, Cook, Anthony, additional, Dodson, Alan, additional, Steingrebe, Katelyn, additional, Flebbe, Dillon R., additional, Nurmukhambetova, Saule T., additional, Godbole, Sucheta, additional, Henry, Amy R., additional, Laboune, Farida, additional, Roberts-Torres, Jesmine, additional, Lorang, Cynthia G., additional, Amin, Shivani, additional, Trost, Jessica, additional, Naisan, Mursal, additional, Basappa, Manjula, additional, Willis, Jacquelyn, additional, Wang, Lingshu, additional, Shi, Wei, additional, Doria-Rose, Nicole A., additional, Olia, Adam S., additional, Liu, Cuiping, additional, Harris, Darcy R., additional, Carfi, Andrea, additional, Mascola, John R., additional, Kwong, Peter D., additional, Edwards, Darin K., additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Corbett, Kizzmekia S., additional, Nason, Martha C., additional, McDermott, Adrian B., additional, Suthar, Mehul S., additional, Moore, Ian N., additional, Roederer, Mario, additional, Sullivan, Nancy J., additional, Douek, Daniel C., additional, and Seder, Robert A., additional

Published
2022
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21. Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

Author

Li, Dapeng, primary, Martinez, David R., additional, Schäfer, Alexandra, additional, Chen, Haiyan, additional, Barr, Maggie, additional, Sutherland, Laura L., additional, Lee, Esther, additional, Parks, Robert, additional, Mielke, Dieter, additional, Edwards, Whitney, additional, Newman, Amanda, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Gagne, Matthew, additional, Douek, Daniel C., additional, DeMarco, C. Todd, additional, Denny, Thomas N., additional, Oguin, Thomas H., additional, Brown, Alecia, additional, Rountree, Wes, additional, Wang, Yunfei, additional, Mansouri, Katayoun, additional, Edwards, Robert J., additional, Ferrari, Guido, additional, Sempowski, Gregory D., additional, Eaton, Amanda, additional, Tang, Juanjie, additional, Cain, Derek W., additional, Santra, Sampa, additional, Pardi, Norbert, additional, Weissman, Drew, additional, Tomai, Mark A., additional, Fox, Christopher B., additional, Moore, Ian N., additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Golding, Hana, additional, Seder, Robert, additional, Khurana, Surender, additional, Baric, Ralph S., additional, Montefiori, David C., additional, Saunders, Kevin O., additional, and Haynes, Barton F., additional

Published
2022
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22. Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung

Author

Gagne, Matthew, primary, Corbett, Kizzmekia S., additional, Flynn, Barbara J., additional, Foulds, Kathryn E., additional, Wagner, Danielle A., additional, Andrew, Shayne F., additional, Todd, John-Paul M., additional, Honeycutt, Christopher Cole, additional, McCormick, Lauren, additional, Nurmukhambetova, Saule T., additional, Davis-Gardner, Meredith E., additional, Pessaint, Laurent, additional, Bock, Kevin W., additional, Nagata, Bianca M., additional, Minai, Mahnaz, additional, Werner, Anne P., additional, Moliva, Juan I., additional, Tucker, Courtney, additional, Lorang, Cynthia G., additional, Zhao, Bingchun, additional, McCarthy, Elizabeth, additional, Cook, Anthony, additional, Dodson, Alan, additional, Teng, I-Ting, additional, Mudvari, Prakriti, additional, Roberts-Torres, Jesmine, additional, Laboune, Farida, additional, Wang, Lingshu, additional, Goode, Adrienne, additional, Kar, Swagata, additional, Boyoglu-Barnum, Seyhan, additional, Yang, Eun Sung, additional, Shi, Wei, additional, Ploquin, Aurélie, additional, Doria-Rose, Nicole, additional, Carfi, Andrea, additional, Mascola, John R., additional, Boritz, Eli A., additional, Edwards, Darin K., additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Suthar, Mehul S., additional, Graham, Barney S., additional, Roederer, Mario, additional, Moore, Ian N., additional, Nason, Martha C., additional, Sullivan, Nancy J., additional, Douek, Daniel C., additional, and Seder, Robert A., additional

Published
2022
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23. Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine–boosted nonhuman primates

Author

Corbett, Kizzmekia S., primary, Gagne, Matthew, additional, Wagner, Danielle A., additional, O’ Connell, Sarah, additional, Narpala, Sandeep R., additional, Flebbe, Dillon R., additional, Andrew, Shayne F., additional, Davis, Rachel L., additional, Flynn, Barbara, additional, Johnston, Timothy S., additional, Stringham, Christopher D., additional, Lai, Lilin, additional, Valentin, Daniel, additional, Van Ry, Alex, additional, Flinchbaugh, Zackery, additional, Werner, Anne P., additional, Moliva, Juan I., additional, Sriparna, Manjari, additional, O’Dell, Sijy, additional, Schmidt, Stephen D., additional, Tucker, Courtney, additional, Choi, Angela, additional, Koch, Matthew, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Alvarado, Gabriela S., additional, Henry, Amy R., additional, Laboune, Farida, additional, Schramm, Chaim A., additional, Zhang, Yi, additional, Yang, Eun Sung, additional, Wang, Lingshu, additional, Choe, Misook, additional, Boyoglu-Barnum, Seyhan, additional, Wei, Shi, additional, Lamb, Evan, additional, Nurmukhambetova, Saule T., additional, Provost, Samantha J., additional, Donaldson, Mitzi M., additional, Marquez, Josue, additional, Todd, John-Paul M., additional, Cook, Anthony, additional, Dodson, Alan, additional, Pekosz, Andrew, additional, Boritz, Eli, additional, Ploquin, Aurélie, additional, Doria-Rose, Nicole, additional, Pessaint, Laurent, additional, Andersen, Hanne, additional, Foulds, Kathryn E., additional, Misasi, John, additional, Wu, Kai, additional, Carfi, Andrea, additional, Nason, Martha C., additional, Mascola, John, additional, Moore, Ian N., additional, Edwards, Darin K., additional, Lewis, Mark G., additional, Suthar, Mehul S., additional, Roederer, Mario, additional, McDermott, Adrian, additional, Douek, Daniel C., additional, Sullivan, Nancy J., additional, Graham, Barney S., additional, and Seder, Robert A., additional

Published
2021
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24. Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in nonhuman primates is coincident with an anamnestic antibody response in the lower airway

Author

Gagne, Matthew, primary, Corbett, Kizzmekia S., additional, Flynn, Barbara J., additional, Foulds, Kathryn E., additional, Wagner, Danielle A., additional, Andrew, Shayne F., additional, Todd, John-Paul M., additional, Honeycutt, Christopher Cole, additional, McCormick, Lauren, additional, Nurmukhambetova, Saule T., additional, Davis-Gardner, Meredith E., additional, Pessaint, Laurent, additional, Bock, Kevin W., additional, Nagata, Bianca M., additional, Minai, Mahnaz, additional, Werner, Anne P., additional, Moliva, Juan I., additional, Tucker, Courtney, additional, Lorang, Cynthia G., additional, Zhao, Bingchun, additional, McCarthy, Elizabeth, additional, Cook, Anthony, additional, Dodson, Alan, additional, Mudvari, Prakriti, additional, Roberts-Torres, Jesmine, additional, Laboune, Farida, additional, Wang, Lingshu, additional, Goode, Adrienne, additional, Kar, Swagata, additional, Boyoglu-Barnum, Seyhan, additional, Yang, Eun Sung, additional, Shi, Wei, additional, Ploquin, Aurélie, additional, Doria-Rose, Nicole, additional, Carfi, Andrea, additional, Mascola, John R., additional, Boritz, Eli A., additional, Edwards, Darin K., additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Suthar, Mehul S., additional, Graham, Barney S., additional, Roederer, Mario, additional, Moore, Ian N., additional, Nason, Martha C., additional, Sullivan, Nancy J., additional, Douek, Daniel C., additional, and Seder, Robert A., additional

Published
2021
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25. An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant viral replication in rhesus macaques

Author

Sui, Yongjun, primary, Li, Jianping, additional, Andersen, Hanne, additional, Zhang, Roushu, additional, Prabhu, Sunaina Kiran, additional, Hoang, Tanya, additional, Venzon, David, additional, Cook, Anthony, additional, Brown, Renita, additional, Teow, Elyse, additional, Velasco, Jason, additional, Pessaint, Laurent, additional, Moore, Ian N., additional, Lagenaur, Laurel, additional, Talton, Jim, additional, Breed, Matthew W., additional, Kramer, Josh, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Choo-Wosoba, Hyoyoung, additional, Lewis, Mark G., additional, Wang, Lai-Xi, additional, and Berzofsky, Jay A., additional

Published
2021
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26. Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

Author

Corbett, Kizzmekia S., primary, Nason, Martha C., additional, Flach, Britta, additional, Gagne, Matthew, additional, O’Connell, Sarah, additional, Johnston, Timothy S., additional, Shah, Shruti N., additional, Edara, Venkata Viswanadh, additional, Floyd, Katharine, additional, Lai, Lilin, additional, McDanal, Charlene, additional, Francica, Joseph R., additional, Flynn, Barbara, additional, Wu, Kai, additional, Choi, Angela, additional, Koch, Matthew, additional, Abiona, Olubukola M., additional, Werner, Anne P., additional, Moliva, Juan I., additional, Andrew, Shayne F., additional, Donaldson, Mitzi M., additional, Fintzi, Jonathan, additional, Flebbe, Dillon R., additional, Lamb, Evan, additional, Noe, Amy T., additional, Nurmukhambetova, Saule T., additional, Provost, Samantha J., additional, Cook, Anthony, additional, Dodson, Alan, additional, Faudree, Andrew, additional, Greenhouse, Jack, additional, Kar, Swagata, additional, Pessaint, Laurent, additional, Porto, Maciel, additional, Steingrebe, Katelyn, additional, Valentin, Daniel, additional, Zouantcha, Serge, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, van de Wetering, Renee, additional, Boyoglu-Barnum, Seyhan, additional, Leung, Kwanyee, additional, Shi, Wei, additional, Yang, Eun Sung, additional, Zhang, Yi, additional, Todd, John-Paul M., additional, Wang, Lingshu, additional, Alvarado, Gabriela S., additional, Andersen, Hanne, additional, Foulds, Kathryn E., additional, Edwards, Darin K., additional, Mascola, John R., additional, Moore, Ian N., additional, Lewis, Mark G., additional, Carfi, Andrea, additional, Montefiori, David, additional, Suthar, Mehul S., additional, McDermott, Adrian, additional, Roederer, Mario, additional, Sullivan, Nancy J., additional, Douek, Daniel C., additional, Graham, Barney S., additional, and Seder, Robert A., additional

Published
2021
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27. Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates

Author

Corbett, Kizzmekia S., primary, Gagne, Matthew, additional, Wagner, Danielle A., additional, Connell, Sarah O’, additional, Narpala, Sandeep R., additional, Flebbe, Dillon R., additional, Andrew, Shayne F., additional, Davis, Rachel L., additional, Flynn, Barbara, additional, Johnston, Timothy S., additional, Stringham, Christopher, additional, Lai, Lilin, additional, Valentin, Daniel, additional, Van Ry, Alex, additional, Flinchbaugh, Zackery, additional, Werner, Anne P., additional, Moliva, Juan I., additional, Sriparna, Manjari, additional, O’Dell, Sijy, additional, Schmidt, Stephen D., additional, Tucker, Courtney, additional, Choi, Angela, additional, Koch, Matthew, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Alvarado, Gabriela S., additional, Henry, Amy R., additional, Laboune, Farida, additional, Schramm, Chaim A., additional, Zhang, Yi, additional, Wang, Lingshu, additional, Choe, Misook, additional, Boyoglu-Barnum, Seyhan, additional, Shi, Wei, additional, Lamb, Evan, additional, Nurmukhambetova, Saule T., additional, Provost, Samantha J., additional, Donaldson, Mitzi M., additional, Marquez, Josue, additional, Todd, John-Paul M., additional, Cook, Anthony, additional, Dodson, Alan, additional, Pekosz, Andrew, additional, Boritz, Eli, additional, Ploquin, Aurélie, additional, Doria-Rose, Nicole, additional, Pessaint, Laurent, additional, Andersen, Hanne, additional, Foulds, Kathryn E., additional, Misasi, John, additional, Wu, Kai, additional, Carfi, Andrea, additional, Nason, Martha C., additional, Mascola, John, additional, Moore, Ian N., additional, Edwards, Darin K., additional, Lewis, Mark G., additional, Suthar, Mehul S., additional, Roederer, Mario, additional, McDermott, Adrian, additional, Douek, Daniel C., additional, Sullivan, Nancy J., additional, Graham, Barney S., additional, and Seder, Robert A., additional

Published
2021
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28. In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies

Author

Li, Dapeng, primary, Edwards, Robert J., additional, Manne, Kartik, additional, Martinez, David R., additional, Schäfer, Alexandra, additional, Alam, S. Munir, additional, Wiehe, Kevin, additional, Lu, Xiaozhi, additional, Parks, Robert, additional, Sutherland, Laura L., additional, Oguin, Thomas H., additional, McDanal, Charlene, additional, Perez, Lautaro G., additional, Mansouri, Katayoun, additional, Gobeil, Sophie M.C., additional, Janowska, Katarzyna, additional, Stalls, Victoria, additional, Kopp, Megan, additional, Cai, Fangping, additional, Lee, Esther, additional, Foulger, Andrew, additional, Hernandez, Giovanna E., additional, Sanzone, Aja, additional, Tilahun, Kedamawit, additional, Jiang, Chuancang, additional, Tse, Longping V., additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Cronin, Kenneth, additional, Gee-Lai, Victoria, additional, Deyton, Margaret, additional, Barr, Maggie, additional, Von Holle, Tarra, additional, Macintyre, Andrew N., additional, Stover, Erica, additional, Feldman, Jared, additional, Hauser, Blake M., additional, Caradonna, Timothy M., additional, Scobey, Trevor D., additional, Rountree, Wes, additional, Wang, Yunfei, additional, Moody, M. Anthony, additional, Cain, Derek W., additional, DeMarco, C. Todd, additional, Denny, Thomas N., additional, Woods, Christopher W., additional, Petzold, Elizabeth W., additional, Schmidt, Aaron G., additional, Teng, I-Ting, additional, Zhou, Tongqing, additional, Kwong, Peter D., additional, Mascola, John R., additional, Graham, Barney S., additional, Moore, Ian N., additional, Seder, Robert, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Montefiori, David C., additional, Sempowski, Gregory D., additional, Baric, Ralph S., additional, Acharya, Priyamvada, additional, Haynes, Barton F., additional, and Saunders, Kevin O., additional

Published
2021
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29. COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge

Author

DiPiazza, Anthony T., primary, Leist, Sarah R., additional, Abiona, Olubukola M., additional, Moliva, Juan I., additional, Werner, Anne, additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Bock, Kevin W., additional, Phung, Emily, additional, Schäfer, Alexandra, additional, Dinnon, Kenneth H., additional, Chang, Lauren A., additional, Loomis, Rebecca J., additional, Boyoglu-Barnum, Seyhan, additional, Alvarado, Gabriela S., additional, Sullivan, Nancy J., additional, Edwards, Darin K., additional, Morabito, Kaitlyn M., additional, Mascola, John R., additional, Carfi, Andrea, additional, Corbett, Kizzmekia S., additional, Moore, Ian N., additional, Baric, Ralph S., additional, Graham, Barney S., additional, and Ruckwardt, Tracy J., additional

Published
2021
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30. mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

Author

Stuart C. Sealfon, Yongchao Ge, Guillaume Stewart-Jones, Xi Chen, Chad E. Mire, Gregory R. Smith, Alexander Bukreyev, Barney S. Graham, Andrea Carfi, Colette Pietzsch, Carole Henry, Darin K. Edwards, Yuan Wang, Palaniappan Ramanathan, Bianca M. Nagata, Angela Woods, Sivakumar Periasamy, Pei Yong Shi, Michelle Meyer, LingZhi Ma, Aliza B. Rubenstein, Irene Ramos, Elena Zaslavsky, Minai Mahnaz, Ian N. Moore, Wan Sze Cheng, Kevin W. Bock, and Olga G. Troyanskaya

Subjects
Lung, Vaccine evaluation, biology, business.industry, Lymphocyte, Article, Transcriptome, Immune system, medicine.anatomical_structure, Immunity, Immunology, biology.protein, Medicine, Antibody, business, Homeostasis
Abstract

The mRNA-1273 vaccine was recently determined to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from interim Phase 3 results. Human studies, however, cannot provide the controlled response to infection and complex immunological insight that are only possible with preclinical studies. Hamsters are the only model that reliably exhibit more severe SARS-CoV-2 disease similar to hospitalized patients, making them pertinent for vaccine evaluation. We demonstrate that prime or prime-boost administration of mRNA-1273 in hamsters elicited robust neutralizing antibodies, ameliorated weight loss, suppressed SARS-CoV-2 replication in the airways, and better protected against disease at the highest prime-boost dose. Unlike in mice and non-human primates, mRNA-1273- mediated immunity was non-sterilizing and coincided with an anamnestic response. Single-cell RNA sequencing of lung tissue permitted high resolution analysis which is not possible in vaccinated humans. mRNA-1273 prevented inflammatory cell infiltration and the reduction of lymphocyte proportions, but enabled antiviral responses conducive to lung homeostasis. Surprisingly, infection triggered transcriptome programs in some types of immune cells from vaccinated hamsters that were shared, albeit attenuated, with mock-vaccinated hamsters. Our results support the use of mRNA-1273 in a two-dose schedule and provides insight into the potential responses within the lungs of vaccinated humans who are exposed to SARS-CoV-2.

Published
2021

31. In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies

Author

Schäfer, Alexandra, Tilahun, Kedamawit, Seder, Robert, Li, Dapeng, Nagata, Bianca M., Feldman, Jared, Janowska, Katarzyna J., Baric, Ralph S., Manne, Kartik, Caradonna, Timothy M., Cronin, Kenneth, Denny, Thomas N., Moore, Ian N., Cain, Derek W., Zhou, Tongqing, Wang, Yunfei, Stover, Erica, Alam1, S. Munir, Minai, Mahnaz, Macintyre, Andrew N., Schmidt, Aaron G., Scobey, Trevor D., Bock, Kevin W., Tse, Longping V., Deyton, Margaret, Moody, M. Anthony, Barr, Maggie, Von Holle, Tarra, Perez, Lautaro G., Lee, Esther, Sutherland, Laura L., Montefiori, David C., Edwards, Robert J., Saunders, Kevin O., McDanal, Charlene, Hernandez, Giovanna E., Mansouri, Katayoun, Parks, Robert, Lu, Xiaozhi, Hauser, Blake M., DeMarco, C. Todd, Cai, Fangping, Graham, Barney S., Wiehe, Kevin, Mascola, John R., Sempowski, Gregory D., Andersen, Hanne, Petzold, Elizabeth W., Martinez, David R., Kwong, Peter D., Gee-Lai, Victoria, Kopp, Megan, Gobeil, Sophie M. C., Stalls, Victoria, Sanzone, Aja, Rountree, Wes, Haynes, Barton F., Lewis, Mark G., Acharya1, Priyamvada, Oguin III, Thomas H., Jiang, Chuancang, Teng, I-Ting, Foulger, Andrew, and Woods, Christopher W.

Subjects
viruses, fungi, respiratory system, skin and connective tissue diseases, respiratory tract diseases
Abstract

SARS-CoV-2 neutralizing antibodies (NAbs) protect against COVID-19. A concern regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we isolated NAbs against the receptor-binding domain (RBD) and the N-terminal domain (NTD) of SARS-CoV-2 spike from individuals with acute or convalescent SARS-CoV-2 or a history of SARS-CoV infection. Cryo-electron microscopy of RBD and NTD antibodies demonstrated function-specific modes of binding. Select RBD NAbs also demonstrated Fc receptor-g (FcgR)-mediated enhancement of virus infection in vitro, while five non-neutralizing NTD antibodies mediated FcgR-independent in vitro infection enhancement. However, both types of infection-enhancing antibodies protected from SARS-CoV-2 replication in monkeys and mice. Three of 46 monkeys infused with enhancing antibodies had higher lung inflammation scores compared to controls. One monkey had alveolar edema and elevated bronchoalveolar lavage inflammatory cytokines. Thus, while in vitro antibody-enhanced infection does not necessarily herald enhanced infection in vivo, increased lung inflammation can rarely occur in SARS-CoV-2 antibody-infused macaques.

Published
2021
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32. Evaluation of mRNA-1273 against SARS-CoV-2 B.1.351 Infection in Nonhuman Primates

Author

Corbett, Kizzmekia S., primary, Werner, Anne P., additional, O’ Connell, Sarah, additional, Gagne, Matthew, additional, Lai, Lilin, additional, Moliva, Juan I., additional, Flynn, Barbara, additional, Choi, Angela, additional, Koch, Matthew, additional, Foulds, Kathryn E., additional, Andrew, Shayne F., additional, Flebbe, Dillon R., additional, Lamb, Evan, additional, Nurmukhambetova, Saule T., additional, Provost, Samantha J., additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Van Ry, Alex, additional, Flinchbaugh, Zackery, additional, Johnston, Timothy S., additional, Mokhtari, Elham Bayat, additional, Mudvari, Prakriti, additional, Henry, Amy R., additional, Laboune, Farida, additional, Chang, Becky, additional, Porto, Maciel, additional, Wear, Jaclyn, additional, Alvarado, Gabriela S., additional, Boyoglu-Barnum, Seyhan, additional, Todd, John-Paul M., additional, Bart, Bridget, additional, Cook, Anthony, additional, Dodson, Alan, additional, Pessaint, Laurent, additional, Steingrebe, Katelyn, additional, Elbashir, Sayda, additional, Andersen, Hanne, additional, Wu, Kai, additional, Edwards, Darin K., additional, Kar, Swagata, additional, Lewis, Mark G., additional, Bortiz, Eli, additional, Moore, Ian N., additional, Carfi, Andrea, additional, Suthar, Mehul S., additional, McDermott, Adrian, additional, Roederer, Mario, additional, Nason, Martha C., additional, Sullivan, Nancy J., additional, Douek, Daniel C., additional, Graham, Barney S., additional, and Seder, Robert A., additional

Published
2021
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33. A single immunization with CAF08 provides newborns with Th1-mediated protection against Respiratory Syncytial Virus infection

Author

van Haren, Simon D., primary, Pedersen, Gabriel, additional, Kumar, Azad, additional, Ruckwardt, Tracy, additional, Moin, Syed, additional, Moore, Ian, additional, Minai, Mahnaz, additional, Liu, Mark, additional, Pak, Jensen, additional, Borriello, Francesco, additional, Ahmed, Saima, additional, Helmel, Michaela, additional, Andersen, Peter, additional, Graham, Barney S, additional, Steen, Hanno, additional, Christensen, Dennis, additional, and Levy, Ofer, additional

Published
2021
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34. Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques

Author

Sui, Yongjun, primary, Li, Jianping, additional, Zhang, Roushu, additional, Prabhu, Sunaina Kiran, additional, Andersen, Hanne, additional, Venzon, David, additional, Cook, Anthony, additional, Brown, Renita, additional, Teow, Elyse, additional, Velasco, Jason, additional, Greenhouse, Jack, additional, Putman-Taylor, Tammy, additional, Campbell, Tracey-Ann, additional, Pessaint, Laurent, additional, Moore, Ian N., additional, Lagenaur, Laurel, additional, Talton, Jim, additional, Breed, Matthew W., additional, Kramer, Josh, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Lewis, Mark G., additional, Wang, Lai-Xi, additional, and Berzofsky, Jay A., additional

Published
2021
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35. Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates

Author

Corbett, Kizzmekia S., primary, Nason, Martha C., additional, Flach, Britta, additional, Gagne, Matthew, additional, O’ Connell, Sarah, additional, Johnston, Timothy S., additional, Shah, Shruti N., additional, Edara, Venkata Viswanadh, additional, Floyd, Katharine, additional, Lai, Lilin, additional, McDanal, Charlene, additional, Francica, Joseph R., additional, Flynn, Barbara, additional, Wu, Kai, additional, Choi, Angela, additional, Koch, Matthew, additional, Abiona, Olubukola M., additional, Werner, Anne P., additional, Alvarado, Gabriela S., additional, Andrew, Shayne F., additional, Donaldson, Mitzi M., additional, Fintzi, Jonathan, additional, Flebbe, Dillon R., additional, Lamb, Evan, additional, Noe, Amy T., additional, Nurmukhambetova, Saule T., additional, Provost, Samantha J., additional, Cook, Anthony, additional, Dodson, Alan, additional, Faudree, Andrew, additional, Greenhouse, Jack, additional, Kar, Swagata, additional, Pessaint, Laurent, additional, Porto, Maciel, additional, Steingrebe, Katelyn, additional, Valentin, Daniel, additional, Zouantcha, Serge, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Moliva, Juan I., additional, van de Wetering, Renee, additional, Boyoglu-Barnum, Seyhan, additional, Leung, Kwanyee, additional, Shi, Wei, additional, Yang, Eun Sung, additional, Zhang, Yi, additional, Todd, John-Paul M., additional, Wang, Lingshu, additional, Andersen, Hanne, additional, Foulds, Kathryn E., additional, Edwards, Darin K., additional, Mascola, John R., additional, Moore, Ian N., additional, Lewis, Mark G., additional, Carfi, Andrea, additional, Montefiori, David, additional, Suthar, Mehul S., additional, McDermott, Adrian, additional, Sullivan, Nancy J., additional, Roederer, Mario, additional, Douek, Daniel C., additional, Graham, Barney S., additional, and Seder, Robert A., additional

Published
2021
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36. A single immunization with CAF08 provides newborns with Th1-mediated protection against Respiratory Syncytial Virus infection

Author

Haren, Simon van, primary, Pedersen, Gabriel Kristian, additional, Kumar, Azad, additional, Ruckwardt, Tracy, additional, Moin, Syed, additional, Moore, Ian, additional, Minai, Mahnaz, additional, Liu, Mark, additional, Pak, Jensen, additional, Borriello, Francesco, additional, Ahmed, Saima, additional, Helmel, Michaela, additional, Andersen, Peter, additional, Graham, Barney, additional, Steen, Hanno, additional, Christensen, Dennis, additional, and Levy, Ofer, additional

Published
2021
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37. Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses

Author

Maximova, Olga A, primary, Sturdevant, Daniel E, additional, Kash, John C, additional, Kanakabandi, Kishore, additional, Xiao, Yongli, additional, Minai, Mahnaz, additional, Moore, Ian N, additional, Taubenberger, Jeff, additional, Martens, Craig, additional, Cohen, Jeffrey I, additional, and Pletnev, Alexander G, additional

Published
2021
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38. mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

Author

Meyer, Michelle, primary, Wang, Yuan, additional, Edwards, Darin, additional, Smith, Gregory R., additional, Rubenstein, Aliza B., additional, Ramanathan, Palaniappan, additional, Mire, Chad E., additional, Pietzsch, Colette, additional, Chen, Xi, additional, Ge, Yongchao, additional, Cheng, Wan Sze, additional, Henry, Carole, additional, Woods, Angela, additional, Ma, LingZhi, additional, Stewart-Jones, Guillaume B. E., additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Periasamy, Sivakumar, additional, Shi, Pei-Yong, additional, Graham, Barney S., additional, Moore, Ian N., additional, Ramos, Irene, additional, Troyanskaya, Olga G., additional, Zaslavsky, Elena, additional, Carfi, Andrea, additional, Sealfon, Stuart C., additional, and Bukreyev, Alexander, additional

Published
2021
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39. Author response: Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses

Author

Maximova, Olga A, primary, Sturdevant, Daniel E, additional, Kash, John C, additional, Kanakabandi, Kishore, additional, Xiao, Yongli, additional, Minai, Mahnaz, additional, Moore, Ian N, additional, Taubenberger, Jeff, additional, Martens, Craig, additional, Cohen, Jeffrey I, additional, and Pletnev, Alexander G, additional

Published
2021
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40. The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

Author

Li, Dapeng, primary, Edwards, Robert J, additional, Manne, Kartik, additional, Martinez, David R., additional, Schäfer, Alexandra, additional, Alam, S. Munir, additional, Wiehe, Kevin, additional, Lu, Xiaozhi, additional, Parks, Robert, additional, Sutherland, Laura L., additional, Oguin, Thomas H., additional, McDanal, Charlene, additional, Perez, Lautaro G., additional, Mansouri, Katayoun, additional, Gobeil, Sophie M. C., additional, Janowska, Katarzyna, additional, Stalls, Victoria, additional, Kopp, Megan, additional, Cai, Fangping, additional, Lee, Esther, additional, Foulger, Andrew, additional, Hernandez, Giovanna E., additional, Sanzone, Aja, additional, Tilahun, Kedamawit, additional, Jiang, Chuancang, additional, Tse, Longping V., additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Cronin, Kenneth, additional, Gee-Lai, Victoria, additional, Deyton, Margaret, additional, Barr, Maggie, additional, Holle, Tarra Von, additional, Macintyre, Andrew N., additional, Stover, Erica, additional, Feldman, Jared, additional, Hauser, Blake M., additional, Caradonna, Timothy M., additional, Scobey, Trevor D., additional, Rountree, Wes, additional, Wang, Yunfei, additional, Moody, M. Anthony, additional, Cain, Derek W., additional, DeMarco, C. Todd, additional, Denny, ThomasN., additional, Woods, Christopher W., additional, Petzold, Elizabeth W., additional, Schmidt, Aaron G., additional, Teng, I-Ting, additional, Zhou, Tongqing, additional, Kwong, Peter D., additional, Mascola, John R., additional, Graham, Barney S., additional, Moore, Ian N., additional, Seder, Robert, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Montefiori, David C., additional, Sempowski, Gregory D., additional, Baric, Ralph S., additional, Acharya, Priyamvada, additional, Haynes, Barton F., additional, and Saunders, Kevin O., additional

Published
2021
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41. Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Author

Corbett, Kizzmekia S., primary, Flynn, Barbara, additional, Foulds, Kathryn E., additional, Francica, Joseph R., additional, Boyoglu-Barnum, Seyhan, additional, Werner, Anne P., additional, Flach, Britta, additional, O’Connell, Sarah, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Andersen, Hanne, additional, Martinez, David R., additional, Noe, Amy T., additional, Douek, Naomi, additional, Donaldson, Mitzi M., additional, Nji, Nadesh N., additional, Alvarado, Gabriela S., additional, Edwards, Darin K., additional, Flebbe, Dillon R., additional, Lamb, Evan, additional, Doria-Rose, Nicole A., additional, Lin, Bob C., additional, Louder, Mark K., additional, O’Dell, Sijy, additional, Schmidt, Stephen D., additional, Phung, Emily, additional, Chang, Lauren A., additional, Yap, Christina, additional, Todd, John-Paul M., additional, Pessaint, Laurent, additional, Van Ry, Alex, additional, Browne, Shanai, additional, Greenhouse, Jack, additional, Putman-Taylor, Tammy, additional, Strasbaugh, Amanda, additional, Campbell, Tracey-Ann, additional, Cook, Anthony, additional, Dodson, Alan, additional, Steingrebe, Katelyn, additional, Shi, Wei, additional, Zhang, Yi, additional, Abiona, Olubukola M., additional, Wang, Lingshu, additional, Pegu, Amarendra, additional, Yang, Eun Sung, additional, Leung, Kwanyee, additional, Zhou, Tongqing, additional, Teng, I-Ting, additional, Widge, Alicia, additional, Gordon, Ingelise, additional, Novik, Laura, additional, Gillespie, Rebecca A., additional, Loomis, Rebecca J., additional, Moliva, Juan I., additional, Stewart-Jones, Guillaume, additional, Himansu, Sunny, additional, Kong, Wing-Pui, additional, Nason, Martha C., additional, Morabito, Kaitlyn M., additional, Ruckwardt, Tracy J., additional, Ledgerwood, Julie E., additional, Gaudinski, Martin R., additional, Kwong, Peter D., additional, Mascola, John R., additional, Carfi, Andrea, additional, Lewis, Mark G., additional, Baric, Ralph S., additional, McDermott, Adrian, additional, Moore, Ian N., additional, Sullivan, Nancy J., additional, Roederer, Mario, additional, Seder, Robert A., additional, and Graham, Barney S., additional

Published
2020
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43. SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

Author

Corbett, Kizzmekia S., primary, Edwards, Darin, additional, Leist, Sarah R., additional, Abiona, Olubukola M., additional, Boyoglu-Barnum, Seyhan, additional, Gillespie, Rebecca A., additional, Himansu, Sunny, additional, Schäfer, Alexandra, additional, Ziwawo, Cynthia T., additional, DiPiazza, Anthony T., additional, Dinnon, Kenneth H., additional, Elbashir, Sayda M., additional, Shaw, Christine A., additional, Woods, Angela, additional, Fritch, Ethan J., additional, Martinez, David R., additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Hutchinson, Geoffrey B., additional, Bahl, Kapil, additional, Garcia-Dominguez, Dario, additional, Ma, LingZhi, additional, Renzi, Isabella, additional, Kong, Wing-Pui, additional, Schmidt, Stephen D., additional, Wang, Lingshu, additional, Zhang, Yi, additional, Stevens, Laura J., additional, Phung, Emily, additional, Chang, Lauren A., additional, Loomis, Rebecca J., additional, Altaras, Nedim Emil, additional, Narayanan, Elisabeth, additional, Metkar, Mihir, additional, Presnyak, Vlad, additional, Liu, Catherine, additional, Louder, Mark K., additional, Shi, Wei, additional, Leung, Kwanyee, additional, Yang, Eun Sung, additional, West, Ande, additional, Gully, Kendra L., additional, Wang, Nianshuang, additional, Wrapp, Daniel, additional, Doria-Rose, Nicole A., additional, Stewart-Jones, Guillaume, additional, Bennett, Hamilton, additional, Nason, Martha C., additional, Ruckwardt, Tracy J., additional, McLellan, Jason S., additional, Denison, Mark R., additional, Chappell, James D., additional, Moore, Ian N., additional, Morabito, Kaitlyn M., additional, Mascola, John R., additional, Baric, Ralph S., additional, Carfi, Andrea, additional, and Graham, Barney S., additional

Published
2020
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44. Prolonged culture of primary human keratinocytes isolated from suction blisters

Author

Ian N. Moore, Sandip K. Datta, Christopher A. Myles, Francisco Otaizo-Carrasquero, Minai Mahnaz, Ian A. Myles, Noah J. Earland, Erik D. Anderson, Inka Sastalla, and Timothy G. Myers

Subjects
Cell type, medicine.anatomical_structure, Cytokine, Epidermis (botany), Dermis, In vivo, medicine.medical_treatment, medicine, Biology, Keratinocyte, In vitro, Cell biology, Suction blister
Abstract

Keratinocytes are the most abundant cell type in the epidermis. They prevent desiccation and provide immunological and barrier defense against potential pathogens such as Staphylococcus aureus and Candida albicans. The study of this first line of immune defense is hindered by invasive isolation methods and insufficient techniques for long-term passage of primary keratinocytes in vitro. Primary keratinocytes have been successfully isolated from blister roofs induced by negative pressure, which separates the epidermis from the dermis in vivo in human subjects. This method allows collection of pure epidermal cells without dermal contamination in a minimally invasive manner. However, the isolated keratinocytes differentiate and senesce when cultured in vitro beyond five passages. Here, we present evidence that the Rho kinase (ROCK) inhibitor Y-27632 can be used to effectively increase the proliferative capabilities of keratinocytes isolated using the suction blister method, similar to what has been previously reported for primary keratinocytes isolated using alternative methods. We show that the increase in passage number is directly correlated to delayed differentiation, and that cells passaged long term with the inhibitor retain their ability to stratify in organotypic raft cultures and respond to cytokine treatment; additionally, the late passage cells have a heterogeneous mix of differentiated and non-differentiated cells which may be predicted by a ratio of select differentiation markers. The described method presents a minimally invasive procedure for keratinocyte isolation and prolonged culture that allows analysis of keratinocyte function in both healthy volunteers and patients with dermatologic diseases.

Published
2018
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45. Prolonging culture of primary human keratinocytes isolated from suction blisters with the Rho kinase inhibitor Y-27632

Author

Christopher A. Myles, Francisco Otaizo-Carrasquero, Ian N. Moore, Erik D. Anderson, Sandip K. Datta, Noah J. Earland, Ian A. Myles, Minai Mahnaz, Inka Sastalla, and Timothy G. Myers

Subjects
0301 basic medicine, Keratinocytes, Cell type, Pyridines, Cell Culture Techniques, lcsh:Medicine, Biology, 03 medical and health sciences, 0302 clinical medicine, Blister, Dermis, medicine, Humans, lcsh:Science, Cells, Cultured, Cell Proliferation, rho-Associated Kinases, Multidisciplinary, Epidermis (botany), lcsh:R, Amides, In vitro, Suction blister, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Rho kinase inhibitor, lcsh:Q, Stem cell, Epidermis, Keratinocyte, 030217 neurology & neurosurgery
Abstract

Keratinocytes are the most abundant cell type in the epidermis. They prevent desiccation and provide immunological and barrier defense against potential pathogens such as Staphylococcus aureus and Candida albicans. The study of this first line of immune defense may be hindered by invasive isolation methods and/or improper culture conditions to support stem cell maintenance and other potential mechanisms contributing to long-term subcultivation in vitro. Primary keratinocytes have been successfully isolated from blister roofs induced by negative pressure, which separates the epidermis from the dermis in vivo in human subjects. This method allows collection of pure epidermal cells without dermal contamination in a minimally invasive manner. However, the isolated keratinocytes differentiate and senesce when cultured in vitro beyond five passages. Here, we present evidence that the Rho kinase (ROCK) inhibitor Y-27632 can be used to effectively increase the proliferative capabilities of keratinocytes isolated using the suction blister method, similar to what has been previously reported for primary keratinocytes isolated using alternative methods. We show that the increase in passage number is directly correlated to delayed differentiation, and that cells passaged long term with the inhibitor retain their ability to stratify in organotypic raft cultures and respond to cytokine treatment; additionally, the late passage cells have a heterogeneous mix of differentiated and non-differentiated cells which may be predicted by a ratio of select differentiation markers. The described method presents a minimally invasive procedure for keratinocyte isolation and prolonged culture that allows analysis of keratinocyte function in both healthy volunteers and patients with dermatologic diseases.

Published
2018

47. Clinical Characterization of Host Response to Simian Hemorrhagic Fever Virus Infection in Permissive and Refractory Hosts: A Model for Determining Mechanisms of VHF Pathogenesis

Author

Cornish, Joseph, primary, Moore, Ian, additional, Perry, Donna, additional, Lara, Abigail, additional, Minai, Mahnaz, additional, Promeneur, Dominique, additional, Hagen, Katie, additional, Virtaneva, Kimmo, additional, Paneru, Monica, additional, Buechler, Connor, additional, O’Connor, David, additional, Bailey, Adam, additional, Cooper, Kurt, additional, Mazur, Steven, additional, Bernbaum, John, additional, Pettitt, James, additional, Jahrling, Peter, additional, Kuhn, Jens, additional, and Johnson, Reed, additional

Published
2019
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48. Clinical Characterization of Host Response to Simian Hemorrhagic Fever Virus Infection in Permissive and Refractory Hosts: A Model for Determining Mechanisms of VHF Pathogenesis

Author

Cornish, Joseph P., primary, Moore, Ian N., additional, Perry, Donna L., additional, Lara, Abigail, additional, Minai, Mahnaz, additional, Promeneur, Dominique, additional, Hagen, Katie R., additional, Virtaneva, Kimmo, additional, Paneru, Monica, additional, Buechler, Connor, additional, O’Connor, David H., additional, Bailey, Adam L., additional, Cooper, Kurt, additional, Mazur, Steven, additional, Bernbaum, John G., additional, Pettitt, James, additional, Jahrling, Peter B., additional, Kuhn, Jens H., additional, and Johnson, Reed F., additional

Published
2018
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49. Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody

Author

Houser, Katherine V., primary, Broadbent, Andrew J., additional, Gretebeck, Lisa, additional, Vogel, Leatrice, additional, Lamirande, Elaine W., additional, Sutton, Troy, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Orandle, Marlene, additional, Moore, Ian N., additional, and Subbarao, Kanta, additional

Published
2017
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