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31 results on '"Minahan, Daniel"'

1. Automorphisms of the fine 1-curve graph

Author

Booth, Katherine Williams, Minahan, Daniel, and Shapiro, Roberta

Subjects
Mathematics - Geometric Topology
Abstract

The fine 1-curve graph of a surface is a graph whose vertices are simple closed curves on the surface and whose edges connect vertices that intersect in at most one point. We show that the automorphism group of the fine 1-curve graph is naturally isomorphic to the homeomorphism group of a closed, orientable surface with genus at least one., Comment: 20 pages, 14 figures

Published
2023

2. The second rational homology of the Torelli group is finitely generated

Author

Minahan, Daniel

Subjects
Mathematics - Geometric Topology
Abstract

We prove that second rational homology of the Torelli group of an orientable closed surface of genus g is finite dimensional for g at least 51. This rules out the simplest obstruction to the Torelli group being finitely presented and provides a partial answer to a question of Bestvina., Comment: 11 figures

Published
2023

3. The acyclicity of the complex of homologous curves

Author

Minahan, Daniel

Subjects
Mathematics - Geometric Topology
Abstract

We show that the complex of homologous curves of a closed, oriented surface of genus g is (g-3)--acyclic., Comment: Added citations of related work of Looijenga. Added a discussion in the introduction regarding the relationship between the results of Section 5 and work of Looijenga on the complex of separating curves

Published
2023

4. The cohomological dimension of the terms of the Johnson filtration

Author

Minahan, Daniel

Subjects
Mathematics - Geometric Topology, Mathematics - General Topology
Abstract

We prove that the $k$th term of the Johnson filtration of a closed, orientable surface of genus $g \geq 2$ has cohomological dimension $2g - 3$ for all $k \geq 3$ and $g \geq 2$. This answers a question of Farb and Bestvina--Bux--Margalit., Comment: Major revision, corrected an error in a proof in Section 2, submitted version

Published
2023

5. All lines on a smooth cubic surface in terms of three skew lines

Author

McKean, Stephen, Minahan, Daniel, and Zhang, Tianyi

Subjects
Mathematics - Algebraic Geometry, 14N15
Abstract

Jordan showed that the incidence variety of a smooth cubic surface containing 27 lines has solvable Galois group over the incidence variety of a smooth cubic surface containing 3 skew lines. As noted by Harris, it follows that for any smooth cubic surface, there exist formulas for all 27 lines in terms of any 3 skew lines. In response to a question of Farb, we compute these formulas explicitly. We also discuss how these formulas relate to Schl\"afli's count of lines on real smooth cubic surfaces., Comment: 21 pages, 5 figures, 1 table. Final version for journal

Published
2020

7. A luminal unfolding microneedle injector for oral delivery of macromolecules

Author

Abramson, Alex, Caffarel-Salvador, Ester, Soares, Vance, Minahan, Daniel, Tian, Ryan Yu, Lu, Xiaoya, and Dellal, David

Subjects
Macromolecules -- Research, Pharmacokinetics -- Research, Drug delivery devices -- Usage, Insulin -- Usage, Biological sciences, Health
Abstract

Insulin and other injectable biologic drugs have transformed the treatment of patients suffering from diabetes.sup.1,2, yet patients and healthcare providers often prefer to use and prescribe less effective orally dosed medications.sup.3-5. Compared with subcutaneously administered drugs, oral formulations create less patient discomfort.sup.4, show greater chemical stability at high temperatures.sup.6, and do not generate biohazardous needle waste.sup.7. An oral dosage form for biologic medications is ideal; however, macromolecule drugs are not readily absorbed into the bloodstream through the gastrointestinal tract.sup.8. We developed an ingestible capsule, termed the luminal unfolding microneedle injector, which allows for the oral delivery of biologic drugs by rapidly propelling dissolvable drug-loaded microneedles into intestinal tissue using a set of unfolding arms. During ex vivo human and in vivo swine studies, the device consistently delivered the microneedles to the tissue without causing complete thickness perforations. Using insulin as a model drug, we showed that, when actuated, the luminal unfolding microneedle injector provided a faster pharmacokinetic uptake profile and a systemic uptake >10% of that of a subcutaneous injection over a 4-h sampling period. With the ability to load a multitude of microneedle formulations, the device can serve as a platform to orally deliver therapeutic doses of macromolecule drugs. A luminal unfolding microneedle injector device (LUMI) is engineered as a custom capsule capable of efficient biologic macromolecular drug delivery into the bloodstream via selective deployment within the gastrointestinal tract., Author(s): Alex Abramson [sup.1] [sup.2] , Ester Caffarel-Salvador [sup.1] [sup.2] [sup.3] , Vance Soares [sup.1] [sup.2] , Daniel Minahan [sup.1] [sup.2] , Ryan Yu Tian [sup.1] [sup.2] , Xiaoya Lu [...]

Published
2019
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10. A microneedle platform for buccal macromolecule delivery

Author

Caffarel-Salvador, Ester, Kim, Soyoung, Soares, Vance, Tian, Ryan Yu, Stern, Sarah R., Minahan, Daniel, Yona, Raissa, Lu, Xiaoya, Zakaria, Fauziah R., Collins, Joy, Wainer, Jacob, Wong, Jessica, McManus, Rebecca, Tamang, Siddartha, McDonnell, Shane, Ishida, Keiko, Hayward, Alison, Liu, Xiewen, Hubalek, Frantisek, Fels, Johannes, Vegge, Andreas, Frederiksen, Morten Revsgaard, Rahbek, Ulrik, Yoshitake, Tadayuki, Fujimoto, James, Roxhed, Niclas, Langer, Robert, Traverso, Giovanni, Caffarel-Salvador, Ester, Kim, Soyoung, Soares, Vance, Tian, Ryan Yu, Stern, Sarah R., Minahan, Daniel, Yona, Raissa, Lu, Xiaoya, Zakaria, Fauziah R., Collins, Joy, Wainer, Jacob, Wong, Jessica, McManus, Rebecca, Tamang, Siddartha, McDonnell, Shane, Ishida, Keiko, Hayward, Alison, Liu, Xiewen, Hubalek, Frantisek, Fels, Johannes, Vegge, Andreas, Frederiksen, Morten Revsgaard, Rahbek, Ulrik, Yoshitake, Tadayuki, Fujimoto, James, Roxhed, Niclas, Langer, Robert, and Traverso, Giovanni

Abstract

Alternative means for drug delivery are needed to facilitate drug adherence and administration. Microneedles (MNs) have been previously investigated transdermally for drug delivery. To date, drug loading into MNs has been limited by drug solubility in the polymeric blend. We designed a highly drug-loaded MN patch to deliver macromolecules and applied it to the buccal area, which allows for faster delivery than the skin. We successfully delivered 1-mg payloads of human insulin and human growth hormone to the buccal cavity of swine within 30 s. In addition, we conducted a trial in 100 healthy volunteers to assess potential discomfort associated with MNs when applied in the oral cavity, identifying the hard palate as the preferred application site. We envisage that MN patches applied on buccal surfaces could increase medication adherence and facilitate the painless delivery of biologics and other drugs to many, especially for the pediatric and elderly populations., QC 20210301

Published
2021
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11. A microneedle platform for buccal macromolecule delivery

Author

Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology. Division of Comparative Medicine, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Research Laboratory of Electronics, Massachusetts Institute of Technology. Department of Mechanical Engineering, Caffarel-Salvador, Ester, Kim, Soyoung, Soares, Vance, Tian, Ryan Yu, Stern, Sarah R, Minahan, Daniel, Yona, Raissa, Lu, Xiaoya, Zakaria, Fauziah R, Collins, Joy, Wainer, Jacob, Wong, Jessica, McManus, Rebecca, Tamang, Siddartha, McDonnell, Shane, Ishida, Keiko, Hayward, Alison, Liu, Xiewen, Hubálek, František, Fels, Johannes, Vegge, Andreas, Frederiksen, Morten Revsgaard, Rahbek, Ulrik, Yoshitake, Tadayuki, Fujimoto, James, Roxhed, Niclas, Langer, Robert, Traverso, Giovanni, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology. Division of Comparative Medicine, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Research Laboratory of Electronics, Massachusetts Institute of Technology. Department of Mechanical Engineering, Caffarel-Salvador, Ester, Kim, Soyoung, Soares, Vance, Tian, Ryan Yu, Stern, Sarah R, Minahan, Daniel, Yona, Raissa, Lu, Xiaoya, Zakaria, Fauziah R, Collins, Joy, Wainer, Jacob, Wong, Jessica, McManus, Rebecca, Tamang, Siddartha, McDonnell, Shane, Ishida, Keiko, Hayward, Alison, Liu, Xiewen, Hubálek, František, Fels, Johannes, Vegge, Andreas, Frederiksen, Morten Revsgaard, Rahbek, Ulrik, Yoshitake, Tadayuki, Fujimoto, James, Roxhed, Niclas, Langer, Robert, and Traverso, Giovanni

Abstract

© 2021 American Association for the Advancement of Science. All rights reserved. Alternative means for drug delivery are needed to facilitate drug adherence and administration. Microneedles (MNs) have been previously investigated transdermally for drug delivery. To date, drug loading into MNs has been limited by drug solubility in the polymeric blend. We designed a highly drug-loaded MN patch to deliver macromolecules and applied it to the buccal area, which allows for faster delivery than the skin. We successfully delivered 1-mg payloads of human insulin and human growth hormone to the buccal cavity of swine within 30 s. In addition, we conducted a trial in 100 healthy volunteers to assess potential discomfort associated with MNs when applied in the oral cavity, identifying the hard palate as the preferred application site. We envisage that MN patches applied on buccal surfaces could increase medication adherence and facilitate the painless delivery of biologics and other drugs to many, especially r the pediatric and elderly populations.

Published
2021

12. 3D‐Printed Gastric Resident Electronics

Author

Kong, Yong Lin, Zou, Xingyu, McCandler, Caitlin A, Kirtane, Ameya R, Ning, Shen, Zhou, Jianlin, Abid, Abubakar, Jafari, Mousa, Rogner, Jaimie, Minahan, Daniel, Collins, Joy E, McDonnell, Shane, Cleveland, Cody, Bensel, Taylor, Tamang, Siid, Arrick, Graham, Gimbel, Alla, Hua, Tiffany, Ghosh, Udayan, Soares, Vance, Wang, Nancy, Wahane, Aniket, Hayward, Alison, Zhang, Shiyi, Smith, Brian R, Langer, Robert, Traverso, Giovanni, Kong, Yong Lin, Zou, Xingyu, McCandler, Caitlin A, Kirtane, Ameya R, Ning, Shen, Zhou, Jianlin, Abid, Abubakar, Jafari, Mousa, Rogner, Jaimie, Minahan, Daniel, Collins, Joy E, McDonnell, Shane, Cleveland, Cody, Bensel, Taylor, Tamang, Siid, Arrick, Graham, Gimbel, Alla, Hua, Tiffany, Ghosh, Udayan, Soares, Vance, Wang, Nancy, Wahane, Aniket, Hayward, Alison, Zhang, Shiyi, Smith, Brian R, Langer, Robert, and Traverso, Giovanni

Abstract

© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Long-term implantation of biomedical electronics into the human body enables advanced diagnostic and therapeutic functionalities. However, most long-term resident electronics devices require invasive procedures for implantation as well as a specialized receiver for communication. Here, a gastric resident electronic (GRE) system that leverages the anatomical space offered by the gastric environment to enable residence of an orally delivered platform of such devices within the human body is presented. The GRE is capable of directly interfacing with portable consumer personal electronics through Bluetooth, a widely adopted wireless protocol. In contrast to the passive day-long gastric residence achieved with prior ingestible electronics, advancement in multimaterial prototyping enables the GRE to reside in the hostile gastric environment for a maximum of 36 d and maintain ≈15 d of wireless electronics communications as evidenced by the studies in a porcine model. Indeed, the synergistic integration of reconfigurable gastric-residence structure, drug release modules, and wireless electronics could ultimately enable the next-generation remote diagnostic and automated therapeutic strategies.

Published
2021

13. Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy

Author

Kirtane, Ameya R., Abouzid, Omar, Minahan, Daniel, Bensel, Taylor, Hill, Alison L., Selinger, Christian, Bershteyn, Anna, Craig, Morgan, Mo, Shirley S., Mazdiyasni, Hormoz, Cleveland, Cody, Rogner, Jaimie, Lee, Young-Ah Lucy, Booth, Lucas, Javid, Farhad, Wu, Sarah J., Grant, Tyler, Bellinger, Andrew M., Nikolic, Boris, Hayward, Alison, Wood, Lowell, Eckhoff, Philip A., Nowak, Martin A., Langer, Robert, and Traverso, Giovanni

Subjects
Anti-HIV Agents, Pyridones, Swine, Science, Rilpivirine, Drug Evaluation, Preclinical, Administration, Oral, Models, Theoretical, Proof of Concept Study, Article, Piperazines, Drug Delivery Systems, Oxazines, Animals, Humans, Patient Compliance, lcsh:Q, lcsh:Science, Heterocyclic Compounds, 3-Ring
Abstract

The efficacy of antiretroviral therapy is significantly compromised by medication non-adherence. Long-acting enteral systems that can ease the burden of daily adherence have not yet been developed. Here we describe an oral dosage form composed of distinct drug–polymer matrices which achieved week-long systemic drug levels of the antiretrovirals dolutegravir, rilpivirine and cabotegravir in a pig. Simulations of viral dynamics and patient adherence patterns indicate that such systems would significantly reduce therapeutic failures and epidemiological modelling suggests that using such an intervention prophylactically could avert hundreds of thousands of new HIV cases. In sum, weekly administration of long-acting antiretrovirals via a novel oral dosage form is a promising intervention to help control the HIV epidemic worldwide., Poor adherence to daily antiretrovirals can significantly affect treatment efficacy, but oral long-acting antiretrovirals are currently lacking. Here, the authors develop a once-weekly oral dosage form for anti-HIV drugs, assess its pharmacokinetics in pigs, and model its impact on viral resistance and disease epidemics.

Published
2018
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14. A microneedle platform for buccal macromolecule delivery

Author

Caffarel-Salvador, Ester, primary, Kim, Soyoung, additional, Soares, Vance, additional, Tian, Ryan Yu, additional, Stern, Sarah R., additional, Minahan, Daniel, additional, Yona, Raissa, additional, Lu, Xiaoya, additional, Zakaria, Fauziah R., additional, Collins, Joy, additional, Wainer, Jacob, additional, Wong, Jessica, additional, McManus, Rebecca, additional, Tamang, Siddartha, additional, McDonnell, Shane, additional, Ishida, Keiko, additional, Hayward, Alison, additional, Liu, Xiewen, additional, Hubálek, František, additional, Fels, Johannes, additional, Vegge, Andreas, additional, Frederiksen, Morten Revsgaard, additional, Rahbek, Ulrik, additional, Yoshitake, Tadayuki, additional, Fujimoto, James, additional, Roxhed, Niclas, additional, Langer, Robert, additional, and Traverso, Giovanni, additional

Published
2021
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15. Mask Reuse in the COVID-19 Pandemic: Creating an Inexpensive and Scalable Ultraviolet System for Filtering Facepiece Respirator Decontamination

Author

Gilbert, Rachel M., primary, Donzanti, Michael J., additional, Minahan, Daniel J., additional, Shirazi, Jasmine, additional, Hatem, Christine L., additional, Hayward-Piatkovskyi, Brielle, additional, Dang, Allyson M., additional, Nelson, Katherine M., additional, Bothi, Kimberly L., additional, and Gleghorn, Jason P., additional

Published
2020
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17. Healthcare worker mask reuse in a global pandemic: Using idle resources to create an inexpensive, scalable, and accessible UV system for N95 sterilization

Author

Gilbert, Rachel M., primary, Donzanti, Michael J., additional, Minahan, Daniel J., additional, Shirazi, Jasmine, additional, Hatem, Christine L., additional, Hayward-Piatkovskyi, Brielle, additional, Dang, Allyson M., additional, Nelson, Katherine M., additional, Bothi, Kimberly L., additional, and Gleghorn, Jason P., additional

Published
2020
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18. A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment

Author

Verma, Malvika, Vishwanath, Karan, Eweje, Feyisope, Roxhed, Niclas, Grant, Tyler, Castaneda, Macy, Steiger, Christoph, Mazdiyasni, Hormoz, Bensel, Taylor, Minahan, Daniel, Soares, Vance, Salama, John A. F., Lopes, Aaron, Hess, Kaitlyn, Cleveland, Cody, Fulop, Daniel J., Hayward, Alison, Collins, Joy, Tamang, Siddartha M., Hua, Tiffany, Ikeanyi, Chinonyelum, Zeidman, Gal, Mule, Elizabeth, Boominathan, Sooraj, Popova, Ellena, Miller, Jonathan B., Bellinger, Andrew M., Collins, David, Leibowitz, Dalia, Batra, Shelly, Ahuja, Sandeep, Bajiya, Manju, Batra, Sonali, Sarin, Rohit, Agarwal, Upasna, Khaparde, Sunil D., Gupta, Neeraj K., Gupta, Deepak, Bhatnagar, Anuj K., Chopra, Kamal K., Sharma, Nandini, Khanna, Ashwani, Chowdhury, Jayeeta, Stoner, Robert, Slocum, Alexander H., Cima, Michael J., Furin, Jennifer, Langer, Robert, Traverso, Giovanni, Verma, Malvika, Vishwanath, Karan, Eweje, Feyisope, Roxhed, Niclas, Grant, Tyler, Castaneda, Macy, Steiger, Christoph, Mazdiyasni, Hormoz, Bensel, Taylor, Minahan, Daniel, Soares, Vance, Salama, John A. F., Lopes, Aaron, Hess, Kaitlyn, Cleveland, Cody, Fulop, Daniel J., Hayward, Alison, Collins, Joy, Tamang, Siddartha M., Hua, Tiffany, Ikeanyi, Chinonyelum, Zeidman, Gal, Mule, Elizabeth, Boominathan, Sooraj, Popova, Ellena, Miller, Jonathan B., Bellinger, Andrew M., Collins, David, Leibowitz, Dalia, Batra, Shelly, Ahuja, Sandeep, Bajiya, Manju, Batra, Sonali, Sarin, Rohit, Agarwal, Upasna, Khaparde, Sunil D., Gupta, Neeraj K., Gupta, Deepak, Bhatnagar, Anuj K., Chopra, Kamal K., Sharma, Nandini, Khanna, Ashwani, Chowdhury, Jayeeta, Stoner, Robert, Slocum, Alexander H., Cima, Michael J., Furin, Jennifer, Langer, Robert, and Traverso, Giovanni

Abstract

Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication., QC 20190509

Published
2019
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19. 3D-Printed Gastric Resident Electronics

Author

Kong, Yong Lin, Zou, Xingyu, McCandler, Caitlin A., Kirtane, Ameya R., Ning, Shen, Zhou, Jianlin, Abid, Abubakar, Jafari, Mousa, Rogner, Jaimie, Minahan, Daniel, Collins, Joy E., McDonnell, Shane, Cleveland, Cody, Bensel, Taylor, Tamang, Siid, Arrick, Graham, Gimbel, Alla, Hua, Tiffany, Ghosh, Udayan, Soares, Vance, Wang, Nancy, Wahane, Aniket, Hayward, Alison, Zhang, Shiyi, Smith, Brian R., Langer, Robert, and Traverso, Giovanni

Subjects
Communication, biomedical devices, ingestible electronics, 3D printing, gastric resident devices, gastric resident electronics
Abstract

Long-term implantation of biomedical electronics into the human body enables advanced diagnostic and therapeutic functionalities. However, most long-term resident electronics devices require invasive procedures for implantation as well as a specialized receiver for communication. Here, a gastric resident electronic (GRE) system that leverages the anatomical space offered by the gastric environment to enable residence of an orally delivered platform of such devices within the human body is presented. The GRE is capable of directly interfacing with portable consumer personal electronics through Bluetooth, a widely adopted wireless protocol. In contrast to the passive day-long gastric residence achieved with prior ingestible electronics, advancement in multimaterial prototyping enables the GRE to reside in the hostile gastric environment for a maximum of 36 d and maintain ≈15 d of wireless electronics communications as evidenced by the studies in a porcine model. Indeed, the synergistic integration of reconfigurable gastric-residence structure, drug release modules, and wireless electronics could ultimately enable the next-generation remote diagnostic and automated therapeutic strategies.

Published
2018

20. A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment

Author

Verma, Malvika, primary, Vishwanath, Karan, additional, Eweje, Feyisope, additional, Roxhed, Niclas, additional, Grant, Tyler, additional, Castaneda, Macy, additional, Steiger, Christoph, additional, Mazdiyasni, Hormoz, additional, Bensel, Taylor, additional, Minahan, Daniel, additional, Soares, Vance, additional, Salama, John A. F., additional, Lopes, Aaron, additional, Hess, Kaitlyn, additional, Cleveland, Cody, additional, Fulop, Daniel J., additional, Hayward, Alison, additional, Collins, Joy, additional, Tamang, Siddartha M., additional, Hua, Tiffany, additional, Ikeanyi, Chinonyelum, additional, Zeidman, Gal, additional, Mule, Elizabeth, additional, Boominathan, Sooraj, additional, Popova, Ellena, additional, Miller, Jonathan B., additional, Bellinger, Andrew M., additional, Collins, David, additional, Leibowitz, Dalia, additional, Batra, Shelly, additional, Ahuja, Sandeep, additional, Bajiya, Manju, additional, Batra, Sonali, additional, Sarin, Rohit, additional, Agarwal, Upasna, additional, Khaparde, Sunil D., additional, Gupta, Neeraj K., additional, Gupta, Deepak, additional, Bhatnagar, Anuj K., additional, Chopra, Kamal K., additional, Sharma, Nandini, additional, Khanna, Ashwani, additional, Chowdhury, Jayeeta, additional, Stoner, Robert, additional, Slocum, Alexander H., additional, Cima, Michael J., additional, Furin, Jennifer, additional, Langer, Robert, additional, and Traverso, Giovanni, additional

Published
2019
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21. All lines on a smooth cubic surface in terms of three skew lines.

Author

McKean, Stephen, Minahan, Daniel, and Tianyi Zhang

Subjects
*SOLVABLE groups
Abstract

Jordan showed that the incidence variety of a smooth cubic surface containing 27 lines has solvable Galois group over the incidence variety of a smooth cubic surface containing 3 skew lines. As noted by Harris, it follows that for any smooth cubic surface, there exist formulas for all 27 lines in terms of any 3 skew lines. In response to a question of Farb, we compute these formulas explicitly. We also discuss how these formulas relate to Schläfii’s count of lines on real smooth cubic surfaces. [ABSTRACT FROM AUTHOR]

Published
2021

23. Complete Derandomization of Identity Testing and Reconstruction of Read-Once Formulas

Author

Minahan, Daniel, Volkovich, Ilya, Minahan, Daniel, and Volkovich, Ilya

Abstract

In this paper we study the identity testing problem of arithmetic read-once formulas (ROF) and some related models. A read-once formula is formula (a circuit whose underlying graph is a tree) in which the operations are {+,x} and such that every input variable labels at most one leaf. We obtain the first polynomial-time deterministic identity testing algorithm that operates in the black-box setting for read-once formulas, as well as some other related models. As an application, we obtain the first polynomial-time deterministic reconstruction algorithm for such formulas. Our results are obtained by improving and extending the analysis of the algorithm of [Shpilka-Volkovich, 2015]

Published
2017
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24. Complete Derandomization of Identity Testing and Reconstruction of Read-Once Formulas

Author

Daniel Minahan and Ilya Volkovich, Minahan, Daniel, Volkovich, Ilya, Daniel Minahan and Ilya Volkovich, Minahan, Daniel, and Volkovich, Ilya

Abstract

In this paper we study the identity testing problem of arithmetic read-once formulas (ROF) and some related models. A read-once formula is formula (a circuit whose underlying graph is a tree) in which the operations are {+,x} and such that every input variable labels at most one leaf. We obtain the first polynomial-time deterministic identity testing algorithm that operates in the black-box setting for read-once formulas, as well as some other related models. As an application, we obtain the first polynomial-time deterministic reconstruction algorithm for such formulas. Our results are obtained by improving and extending the analysis of the algorithm of [Shpilka-Volkovich, 2015]

Published
2017
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25. Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice

Author

Schoellhammer, Carl M., primary, Lauwers, Gregory Y., additional, Goettel, Jeremy A., additional, Oberli, Matthias A., additional, Cleveland, Cody, additional, Park, June Y., additional, Minahan, Daniel, additional, Chen, Yiyun, additional, Anderson, Daniel G., additional, Jaklenec, Ana, additional, Snapper, Scott B., additional, Langer, Robert, additional, and Traverso, Giovanni, additional

Published
2017
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26. Oral, ultra–long-lasting drug delivery: Application toward malaria elimination goals

Author

Bellinger, Andrew M., primary, Jafari, Mousa, additional, Grant, Tyler M., additional, Zhang, Shiyi, additional, Slater, Hannah C., additional, Wenger, Edward A., additional, Mo, Stacy, additional, Lee, Young-Ah Lucy, additional, Mazdiyasni, Hormoz, additional, Kogan, Lawrence, additional, Barman, Ross, additional, Cleveland, Cody, additional, Booth, Lucas, additional, Bensel, Taylor, additional, Minahan, Daniel, additional, Hurowitz, Haley M., additional, Tai, Tammy, additional, Daily, Johanna, additional, Nikolic, Boris, additional, Wood, Lowell, additional, Eckhoff, Philip A., additional, Langer, Robert, additional, and Traverso, Giovanni, additional

Published
2016
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27. BROOKE SMITH

Author

MINAHAN, DANIEL

Subjects
Actresses -- Interviews
Published
2001

29. Director's cut

Author

Minahan, Daniel

Subjects
Camcorders -- Product/service Evaluations, Travel, recreation and leisure
Published
2006

30. 3D‐Printed Gastric Resident Electronics.

Author

Kong, Yong Lin, Zou, Xingyu, McCandler, Caitlin A., Kirtane, Ameya R., Ning, Shen, Zhou, Jianlin, Abid, Abubakar, Jafari, Mousa, Rogner, Jaimie, Minahan, Daniel, Collins, Joy E., McDonnell, Shane, Cleveland, Cody, Bensel, Taylor, Tamang, Siid, Arrick, Graham, Gimbel, Alla, Hua, Tiffany, Ghosh, Udayan, and Soares, Vance

Subjects
MEDICAL electronics
Abstract

Long‐term implantation of biomedical electronics into the human body enables advanced diagnostic and therapeutic functionalities. However, most long‐term resident electronics devices require invasive procedures for implantation as well as a specialized receiver for communication. Here, a gastric resident electronic (GRE) system that leverages the anatomical space offered by the gastric environment to enable residence of an orally delivered platform of such devices within the human body is presented. The GRE is capable of directly interfacing with portable consumer personal electronics through Bluetooth, a widely adopted wireless protocol. In contrast to the passive day‐long gastric residence achieved with prior ingestible electronics, advancement in multimaterial prototyping enables the GRE to reside in the hostile gastric environment for a maximum of 36 d and maintain ≈15 d of wireless electronics communications as evidenced by the studies in a porcine model. Indeed, the synergistic integration of reconfigurable gastric‐residence structure, drug release modules, and wireless electronics could ultimately enable the next‐generation remote diagnostic and automated therapeutic strategies. 3D‐printed orally delivered gastric resident electronic devices allow a needle and surgical‐free synergistic integration of biomedical electronics, the human body, and the digital domain. A maximum gastric residence of 36 and 15.3 d of wireless Bluetooth communication is demonstrated in a hostile gastric environment, enabling the next‐generation remote diagnostic and automated therapeutic strategies. [ABSTRACT FROM AUTHOR]

Published
2019
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31. Boland vs. self-preservation

Author

Dornan, Robert K., Minahan, Daniel F., and MacMillin, Frederick N.

Subjects
Iran-Contra Affair, 1985-1990 -- Laws, regulations and rules, Presidents -- Powers and duties, Separation of powers -- Interpretation and construction, Business, Business, general, Department of Defense Authorization Act of 1975
Published
1987

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