Search

Your search keyword '"Mina, Sara"' showing total 34 results
Start Over Author "Mina, Sara"
34 results on '"Mina, Sara"'

6. Correction to: Proposed nomenclature for Pseudallescheria, Scedosporium and related genera

Author

Lackner, Michaela, de Hoog, G. Sybren, Yang, Liyue, Ferreira Moreno, Leandro, Ahmed, Sarah A., Andreas, Fritz, Kaltseis, Josef, Nagl, Markus, Lass-Flörl, Cornelia, Risslegger, Brigitte, Rambach, Günter, Speth, Cornelia, Robert, Vincent, Buzina, Walter, Chen, Sharon, Bouchara, Jean-Philippe, Cano-Lira, José F., Guarro, Josep, Gené, Josepa, Fernández Silva, Fabiola, Haido, Rosa, Haase, Gerhard, Havlicek, Vladimir, Garcia-Hermoso, Dea, Meis, Jacques F., Hagen, Ferry, Kirchmair, Martin, Rainer, Johannes, Schwabenbauer, Katharina, Zoderer, Mirjam, Meyer, Wieland, Gilgado, Felix, Schwabenbauer, Katharina, Vicente, Vania A., Piecková, Elena, Regenermel, Monika, Rath, Peter-Michael, Steinmann, Joerg, de Alencar, Xisto Wellington, Symoens, Françoise, Tintelnot, Kathrin, Ulfig, Krzysztof, Velegraki, Aristea, Tortorano, Anna Maria, Giraud, Sandrine, Mina, Sara, Rigler-Hohenwarter, Kinga, Hernando, Fernando L., Ramirez-Garcia, Andoni, Pellon, Aize, Kaur, Jashanpreet, Bergter, Eliana Barreto, de Meirelles, Jardel Vieira, da Silva, Ingrid Dutra, Delhaes, Laurence, Alastruey-Izquierdo, Ana, Li, Ruo-yu, Lu, Qiaoyun, Moussa, Tarek, Almaghrabi, Omar, Al-Zahrani, Hassan, Okada, Gen, Deng, Shuwen, Liao, Wangqing, Zeng, Jingsi, Issakainen, Jouni, and Liporagi Lopes, Livia Cristina

Published
2022
Full Text
View/download PDF

9. Proposed nomenclature for Pseudallescheria, Scedosporium and related genera (vol 67, pg 1, 2014)

Author

Lackner, Michaela, de Hoog, G. Sybren, Yang, Liyue, Ferreira Moreno, Leandro, Ahmed, Sarah A., Andreas, Fritz, Kaltseis, Josef, Nagl, Markus, Lass-Floerl, Cornelia, Risslegger, Brigitte, Rambach, Guenter, Speth, Cornelia, Robert, Vincent, Buzina, Walter, Chen, Sharon, Bouchara, Jean-Philippe, Cano-Lira, Jose F., Guarro, Josep, Gene, Josepa, Fernandez Silva, Fabiola, Haido, Rosa, Haase, Gerhard, Havlicek, Vladimir, Garcia-Hermoso, Dea, Meis, Jacques F., Hagen, Ferry, Kirchmair, Martin, Rainer, Johannes, Schwabenbauer, Katharina, Zoderer, Mirjam, Meyer, Wieland, Gilgado, Felix, Vicente, Vania A., Pieckova, Elena, Regenermel, Monika, Rath, Peter-Michael, Steinmann, Joerg, de Alencar, Xisto Wellington, Symoens, Francoise, Tintelnot, Kathrin, Ulfig, Krzysztof, Velegraki, Aristea, Tortorano, Anna Maria, Giraud, Sandrine, Mina, Sara, Rigler-Hohenwarter, Kinga, Hernando, Fernando L., Ramirez-Garcia, Andoni, Pellon, Aize, Kaur, Jashanpreet, Bergter, Eliana Barreto, de Meirelles, Jardel Vieira, da Silva, Ingrid Dutra, Delhaes, Laurence, Alastruey-Izquierdo, Ana, Li, Ruo-yu, Lu, Qiaoyun, Moussa, Tarek, Almaghrabi, Omar, Al-Zahrani, Hassan, Okada, Gen, Deng, Shuwen, Liao, Wangqing, Zeng, Jingsi, Issakainen, Jouni, Liporagi Lopes, Livia Cristina, Lackner, Michaela, de Hoog, G. Sybren, Yang, Liyue, Ferreira Moreno, Leandro, Ahmed, Sarah A., Andreas, Fritz, Kaltseis, Josef, Nagl, Markus, Lass-Floerl, Cornelia, Risslegger, Brigitte, Rambach, Guenter, Speth, Cornelia, Robert, Vincent, Buzina, Walter, Chen, Sharon, Bouchara, Jean-Philippe, Cano-Lira, Jose F., Guarro, Josep, Gene, Josepa, Fernandez Silva, Fabiola, Haido, Rosa, Haase, Gerhard, Havlicek, Vladimir, Garcia-Hermoso, Dea, Meis, Jacques F., Hagen, Ferry, Kirchmair, Martin, Rainer, Johannes, Schwabenbauer, Katharina, Zoderer, Mirjam, Meyer, Wieland, Gilgado, Felix, Vicente, Vania A., Pieckova, Elena, Regenermel, Monika, Rath, Peter-Michael, Steinmann, Joerg, de Alencar, Xisto Wellington, Symoens, Francoise, Tintelnot, Kathrin, Ulfig, Krzysztof, Velegraki, Aristea, Tortorano, Anna Maria, Giraud, Sandrine, Mina, Sara, Rigler-Hohenwarter, Kinga, Hernando, Fernando L., Ramirez-Garcia, Andoni, Pellon, Aize, Kaur, Jashanpreet, Bergter, Eliana Barreto, de Meirelles, Jardel Vieira, da Silva, Ingrid Dutra, Delhaes, Laurence, Alastruey-Izquierdo, Ana, Li, Ruo-yu, Lu, Qiaoyun, Moussa, Tarek, Almaghrabi, Omar, Al-Zahrani, Hassan, Okada, Gen, Deng, Shuwen, Liao, Wangqing, Zeng, Jingsi, Issakainen, Jouni, and Liporagi Lopes, Livia Cristina

Published
2022

12. A Stress Hub in Scedosporium apiospermum : The High Osmolarity Glycerol (HOG) Pathway.

Author

Yaakoub, Hajar, Mina, Sara, Marot, Agnès, Papon, Nicolas, Calenda, Alphonse, and Bouchara, Jean-Philippe

Subjects
*OSMOLAR concentration, *SORBITOL, *SWINE, *AMPHOTERICIN B, *CONGO red (Staining dye), *GLYCERIN, *VORICONAZOLE
Abstract

Scedosporium species are opportunistic filamentous fungi found in human-impacted areas. Clinically relevant species, such as S. apiospermum, rank as the second most frequent colonizers of the airways of patients with cystic fibrosis (CF), which are characterized by persistent oxidative stress. This raises the question of how Scedosporium species abate conditions imposed in hostile environments. Since the High Osmolarity Glycerol (HOG) pathway plays a central role in fungal adaptation to stress, we aimed to pheno-profile the involvement of the pathway in response to stress in S. apiospermum using Western blot. We show for the first time that a wide range of stress distinctively activates the HOG pathway in S. apiospermum, including oxidants (H2O2, menadione, cumene hydroperoxide, diamide, paraquat, and honokiol), osmotic agents (sorbitol and KCl), cell-wall stress agents (caffeine, calcofluor white, and Congo Red), heavy metals (cadmium and arsenite), fungicides (fludioxonil and iprodione), antifungals (voriconazole and amphotericin B), and acid stress (pH 4). We suggest that the function of the HOG pathway as a general stress regulator is also conserved in S. apiospermum. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

13. Proposed nomenclature for Pseudallescheria, Scedosporium and related genera

Author

Lackner, Michaela, de Hoog, G. Sybren, Yang, Liyue, Ferreira Moreno, Leandro, Ahmed, Sarah A., Andreas, Fritz, Kaltseis, Josef, Nagl, Markus, Lass-Flörl, Cornelia, Risslegger, Brigitte, Rambach, Günter, Speth, Cornelia, Robert, Vincent, Buzina, Walter, Chen, Sharon, Bouchara, Jean-Philippe, Cano-Lira, José F., Guarro, Josep, Gené, Josepa, Fernández Silva, Fabiola, Haido, Rosa, Haase, Gerhard, Havlicek, Vladimir, Garcia-Hermoso, Dea, Meis, Jacques F., Hagen, Ferry, Kirchmair, Martin, Rainer, Johannes, Schwabenbauer, Katharina, Zoderer, Mirjam, Meyer, Wieland, Gilgado, Felix, Schwabenbauer, Katharina, Vicente, Vania A., Piecková, Elena, Regenermel, Monika, Rath, Peter-Michael, Steinmann, Joerg, de Alencar, Xisto Wellington, Symoens, Françoise, Tintelnot, Kathrin, Ulfig, Krzysztof, Velegraki, Aristea, Tortorano, Anna Maria, Giraud, Sandrine, Mina, Sara, Rigler-Hohenwarter, Kinga, Hernando, Fernando L., Ramirez-Garcia, Andoni, Pellon, Aize, Kaur, Jashanpreet, Bergter, Eliana Barreto, de Meirelles, Jardel Vieira, da Silva, Ingrid Dutra, Delhaes, Laurence, Alastruey-Izquerdo, Ana, Li, Ruo-yu, Lu, Qiaoyun, Moussa, Tarek, Almaghrabi, Omar, Al-Zahrani, Hassan, Okada, Gen, Deng, Shuwen, Liao, Wangqing, Zeng, Jingsi, Issakainen, Jouni, and Liporagi Lopes, Livia Cristina

Published
2014
Full Text
View/download PDF

16. Assessment of Drug-Induced Toxicity Biomarkers in the Brain Microphysiological System (MPS) Using Targeted and Untargeted Molecular Profiling

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Mina, Sara G., Alaybeyoglu, Begum, Murphy, William L., Thomson, James A., Stokes, Cynthia L., Cirit, Murat, Massachusetts Institute of Technology. Department of Biological Engineering, Mina, Sara G., Alaybeyoglu, Begum, Murphy, William L., Thomson, James A., Stokes, Cynthia L., and Cirit, Murat

Abstract

Early assessment of adverse drug effects in humans is critical to avoid long-lasting harm. However, current approaches for early detection of adverse effects still lack predictive and organ-specific biomarkers to evaluate undesired responses in humans. Microphysiological systems (MPSs) are in vitro representations of human tissues and provide organ-specific translational insights for physiological processes. In this study, a brain MPS was utilized to assess molecular signatures of neurotoxic and non-neurotoxic compounds using targeted and untargeted molecular approaches. The brain MPS comprising of human embryonic stem (ES) cell-derived neural progenitor cells seeded on three-dimensional (3D), chemically defined, polyethylene glycol hydrogels was treated with the neurotoxic drug, bortezomib and the non-neurotoxic drug, tamoxifen over 14-days. Possible toxic effects were monitored with human N-acetylaspartic acid (NAA) kinetics, which correlates the neuronal function/health and DJ-1/PARK7, an oxidative stress biomarker. Changes in NAA levels were observed as early as 2-days post-bortezomib treatment, while onset detection of oxidative stress (DJ-1) was delayed until 4-days post-treatment. Separately, the untargeted extracellular metabolomics approach revealed distinct fingerprints 2-days post-bortezomib treatment as perturbations in cysteine and glycerophospholipid metabolic pathways. These results suggest accumulation of reactive oxygen species associated with oxidative stress, and disruption of membrane structure and integrity. The NAA response was strongly correlated with changes in a subset of the detected metabolites at the same time point 2-days post-treatment. Moreover, these metabolite changes correlated strongly with DJ-1 levels measured at the later time point (4-days post-treatment). This suggests that early cellular metabolic dysfunction leads to later DJ-1 leakage and cell death, and that early measurement of this subset of metabolites could predict the, National Center for Advancing Translational Sciences (Award NIH-U24TR001951), National Center for Advancing Translational Sciences (Award NIH-UH3TR000506-03)

Published
2020

18. Repurposing of auranofin and honokiol as antifungals against Scedosporiumspecies and the related fungus Lomentospora prolificans

Author

Yaakoub, Hajar, Staerck, Cindy, Mina, Sara, Godon, Charlotte, Fleury, Maxime, Bouchara, Jean-Philippe, and Calenda, Alphonse

Abstract

ABSTRACTThe slowing-down de novodrug-discovery emphasized the importance of repurposing old drugs. This is particularly true when combating infections caused by therapy-refractory microorganisms, such as Scedosporiumspecies and Lomentospora prolificans. Recent studies on Scedosporiumresponses to oxidative stress underscored the importance of targeting the underlying mechanisms. Auranofin, ebselen, PX-12, honokiol, and to a lesser extent, conoidin A are known to disturb redox-homeostasis systems in many organisms. Their antifungal activity was assessed against 27 isolates belonging to the major Scedosporiumspecies: S. apiospermum, S. aurantiacum, S. boydii, S. dehoogii, S. minutisporum, and Lomentospora prolificans. Auranofin and honokiol were the most active against all Scedosporiumspecies (mean MIC50values of 2.875 and 6.143 μg/ml, respectively) and against L. prolificansisolates (mean MIC50values of 4.0 and 3.563 μg/ml respectively). Combinations of auranofin with voriconazole or honokiol revealed additive effects against 9/27 and 18/27 isolates, respectively. Synergistic interaction between auranofin and honokiol was only found against one isolate of L. prolificans. The effects of auranofin upon exposure to oxidative stress were also investigated. For all species except S. dehoogii, the maximal growth in the presence of auranofin significantly decreased when adding a sublethal dose of menadione. The analysis of the expression of genes encoding oxidoreductase enzymes upon exposure of S. apiospermumto honokiol unveiled the upregulation of many genes, especially those coding peroxiredoxins, thioredoxin reductases, and glutaredoxins. Altogether, these data suggest that auranofin and honokiol act via dampening the redox balance and support their repurposing as antifungals against Scedosporiumspecies and L. prolificans.

Published
2021
Full Text
View/download PDF

20. Etude de l’implication des gènes codant la catalase A1 et la Cu,Zn-superoxyde dismutase de Scedosporium apiospermum dans sa défence contre le stress oxydant

Author

Staerck, Cindy, Mina, Sara, d'Almeida, Sènan, Marot, Agnès, Delneste, Yves, Bouchara, Jean-Philippe, Tabiasco, Julie, Fleury, Maxime, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Innate Immunity and Immunotherapy (CRCINA-ÉQUIPE 7), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2015

23. Etude de la réponse de Scedosporium apiospermum au stress oxydatif

Author

Staerck, Cindy, Mina, Sara, d'Almeida, Sènan, Marot, Agnès, Bouchara, Jean-Philippe, Tabiasco, Julie, Fleury, Maxime, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Innate Immunity and Immunotherapy (CRCINA-ÉQUIPE 7), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2015

24. Scedosporium apiospermum defense systems against oxidative stress

Author

Staerck, Cindy, Mina, Sara, d'Almeida, Sènan, Marot, Agnès, Giraud, Sandrine, Delneste, Yves, Bouchara, Jean-Philippe, Tabiasco, Julie, Fleury, Maxime, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Innate Immunity and Immunotherapy (CRCINA-ÉQUIPE 7), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

26. Production de protéines recombinantes de Scedosporium apiospermum, Cu,Zn superoxide dismutase et catalase, pour l’amélioration et la standardisation du sérodiagnostic des infections à Scedosporium apiospermum chez les patients atteints de mucoviscidose

Author

Mina, Sara, Staerck, Cindy, Marot, Agnès, Godon, Charlotte, Robert, Raymond, Bouchara, Jean-Philippe, Fleury, Maxime, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), and Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2014

27. Catalase de Pseudallescheria boydii : un facteur de pathogénicité

Author

Mina, Sara, Marot, Agnès, Fleury, Maxime, Cimon, Bernard, Bouchara, Jean-Philippe, Robert, Raymond, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), and Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2014

28. Identification et caractérisation d’une catalase de Pseudallescheria boydii, évaluation de son intérêt pour le sérodiagnostic des infections à Pseudallescheria/Scedosporium chez les patients atteints de mucoviscidose

Author

Mina, Sara, Marot, Agnès, Fleury, Maxime, Bouchara, Jean-Philippe, Robert, Raymond, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), and Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2014

34. Purification and characterization of a mycelial catalase from Scedosporium boydii, a useful tool for specific antibody detection in patients with cystic fibrosis.

Author

Mina S, Marot-Leblond A, Cimon B, Fleury MJ, Larcher G, Bouchara JP, and Robert R

Subjects
Chromatography, Liquid methods, Enzyme-Linked Immunosorbent Assay methods, Humans, Molecular Weight, Mycelium enzymology, Protein Multimerization, Serologic Tests methods, Antibodies, Fungal blood, Antigens, Fungal chemistry, Antigens, Fungal isolation & purification, Catalase chemistry, Catalase isolation & purification, Cystic Fibrosis complications, Mycoses diagnosis, Scedosporium enzymology
Abstract

Scedosporium boydii is an opportunistic filamentous fungus which may be responsible for a wide variety of infections in immunocompetent and immunocompromised individuals. This fungus belongs to the Scedosporium apiospermum species complex, which usually ranks second among the filamentous fungi colonizing the airways of patients with cystic fibrosis (CF) and may lead to allergic bronchopulmonary mycoses, sensitization, or respiratory infections. Upon microbial infection, host phagocytic cells release reactive oxygen species (ROS), such as hydrogen peroxide, as part of the antimicrobial response. Catalases are known to protect pathogens against ROS by detoxification of the hydrogen peroxide. Here, we investigated the catalase equipment of Scedosporium boydii, one of the major pathogenic species in the S. apiospermum species complex. Three catalases were identified, and the mycelial catalase A1 was purified to homogeneity by a three-step chromatographic process. This enzyme is a monofunctional tetrameric protein of 460 kDa, consisting of four 82-kDa glycosylated subunits. The potential usefulness of this enzyme in serodiagnosis of S. apiospermum infections was then investigated by an enzyme-linked immunosorbent assay (ELISA), using 64 serum samples from CF patients. Whatever the species involved in the S. apiospermum complex, sera from infected patients were clearly differentiated from sera from patients with an Aspergillus fumigatus infection or those from CF patients without clinical and biological signs of a fungal infection and without any fungus recovered from sputum samples. These results suggest that catalase A1 is a good candidate for the development of an immunoassay for serodiagnosis of infections caused by the S. apiospermum complex in patients with CF., (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results