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2 results on '"Min-xin Cao"'

1. Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma.

Author

Xiao-Lei Gao, Jia-Shun Wu, Min-Xin Cao, Shi-Yu Gao, Xiao Cen, Ya-Ping Jiang, Sha-Sha Wang, Ya-Jie Tang, Qian-Ming Chen, Xin-Hua Liang, and Yaling Tang

Subjects
Medicine, Science
Abstract

Collective invasion of cells plays a fundamental role in tissue growth, wound healing, immune response and cancer metastasis. This paper aimed to investigate cytokeratin-14 (CK14) expression and analyze its association with collective invasion in the invasive front of salivary adenoid cystic carcinoma (SACC) to uncover the role of collective invasion in SACC. Here, in the clinical data of 121 patients with SACC, the positive expression of CK14 was observed in 35/121(28.93%) of the invasive front of SACC. CK14 expression in the invasive front, local regional recurrence and distant metastasis were independent and significant prognostic factors in SACC patients. Then, we found that in an ex vivo 3D culture assay, CK14 siRNA receded the collective invasion, and in 2D monolayer culture, CK14 overexpression induced a collective SACC cell migration. These data indicated that the presence of characterized CK14+ cells in the invasive front of SACC promoted collective cell invasion of SACC and may be a biomarker of SACC with a worse prognosis.

Published
2017
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2. Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma

Author

Ya-ling Tang, Min-xin Cao, Ya-ping Jiang, Xiao Cen, Xiao-lei Gao, Ya-Jie Tang, Xin-hua Liang, Jia-Shun Wu, Qianming Chen, Sha-sha Wang, and Shi-yu Gao

Subjects
0301 basic medicine, Male, lcsh:Medicine, Biochemistry, Salivary Glands, Metastasis, Tissue Culture Techniques, 0302 clinical medicine, Basic Cancer Research, Medicine and Health Sciences, Small interfering RNAs, Organ Cultures, lcsh:Science, Multidisciplinary, Cell migration, Middle Aged, Prognosis, Salivary Gland Neoplasms, Head and Neck Tumors, Carcinoma, Adenoid Cystic, Organoids, Nucleic acids, Cell Motility, Oncology, 030220 oncology & carcinogenesis, Biomarker (medicine), Female, Biological Cultures, Anatomy, Research Article, Adenoid cystic carcinoma, Cell Migration, Biology, Research and Analysis Methods, Carcinomas, 03 medical and health sciences, Cytokeratin, Immune system, Exocrine Glands, Diagnostic Medicine, Carcinoma, medicine, Genetics, Humans, Neoplasm Invasiveness, Salivary Gland Tumors, Non-coding RNA, lcsh:R, Keratin-14, Biology and Life Sciences, Cancers and Neoplasms, Cell Biology, medicine.disease, Gene regulation, stomatognathic diseases, 030104 developmental biology, Cancer research, RNA, lcsh:Q, Gene expression, Wound healing, Digestive System, Developmental Biology
Abstract

Collective invasion of cells plays a fundamental role in tissue growth, wound healing, immune response and cancer metastasis. This paper aimed to investigate cytokeratin-14 (CK14) expression and analyze its association with collective invasion in the invasive front of salivary adenoid cystic carcinoma (SACC) to uncover the role of collective invasion in SACC. Here, in the clinical data of 121 patients with SACC, the positive expression of CK14 was observed in 35/121(28.93%) of the invasive front of SACC. CK14 expression in the invasive front, local regional recurrence and distant metastasis were independent and significant prognostic factors in SACC patients. Then, we found that in an ex vivo 3D culture assay, CK14 siRNA receded the collective invasion, and in 2D monolayer culture, CK14 overexpression induced a collective SACC cell migration. These data indicated that the presence of characterized CK14+ cells in the invasive front of SACC promoted collective cell invasion of SACC and may be a biomarker of SACC with a worse prognosis.

Published
2017

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