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Objective Vaginal morphology and pelvic floor muscle (PFM) strength may influence sexual stimulation, sensation, and orgasmic response. This study aimed to determine the relationship between female sexual function and PFM strength and vaginal morphology (represented by vaginal resting tone and vaginal volume) in women with stress urinary incontinence (SUI). Methods Forty-two subjects with SUI were recruited for the study. Female sexual function was measured using the female sexual function index (FSFI) questionnaire. PFM strength was measured by digital palpation. Vaginal resting tone (mmHg) and vaginal volume (mL) were measured using a perineometer. The significance of the correlations between female sexual function and PFM function and hip muscle strength was assessed using Pearson’s correlation coefficients. If a significant correlation between vaginal morphology and FSFI score was confirmed using Pearson’s correlation, the cutoff value was confirmed through a decision tree. Results PFM strength was significantly correlated with desire (r=0.397), arousal (r=0.388), satisfaction (r=0.326), and total (r=0.315) FSFI scores. Vaginal resting tone (r=-0.432) and vaginal volume (r=0.332) were significantly correlated with the FSFI pain score. The cutoff point of vaginal resting tone for the presence of pain-related sexual dysfunction was >15.2 mmHg. Conclusion PFM strength training should be the first strategy to improve female sexual function. Additionally, because of the relationship between vaginal morphology and pain-related sexual dysfunction, surgical procedures to achieve vaginal rejuvenation should be carefully considered.

Abstract Background Previous investigations of transcriptomic signatures of cancer patient survival and post-therapy relapse have focused on tumor tissue. In contrast, here we show that in colorectal cancer (CRC) transcriptomes derived from normal tissues adjacent to tumors (NATs) are better predictors of relapse. Results Using the transcriptomes of paired tumor and NAT specimens from 80 Korean CRC patients retrospectively determined to be in recurrence or nonrecurrence states, we found that, when comparing recurrent with nonrecurrent samples, NATs exhibit a greater number of differentially expressed genes (DEGs) than tumors. Training two prognostic elastic net-based machine learning models—NAT-based and tumor-based in our Samsung Medical Center (SMC) cohort, we found that NAT-based model performed better in predicting the survival when the model was applied to the tumor-derived transcriptomes of an independent cohort of 450 COAD patients in TCGA. Furthermore, compositions of tumor-infiltrating immune cells in NATs were found to have better prognostic capability than in tumors. We also confirmed through Cox regression analysis that in both SMC-CRC as well as in TCGA-COAD cohorts, a greater proportion of genes exhibited significant hazard ratio when NAT-derived transcriptome was used compared to when tumor-derived transcriptome was used. Conclusions Taken together, our results strongly suggest that NAT-derived transcriptomes and immune cell composition of CRC are better predictors of patient survival and tumor recurrence than the primary tumor.

Bioaerosols are small airborne particles composed of microbiological fragments, including bacteria, viruses, fungi, pollens, and/or by-products of cells, which may be viable or non-viable wherever applicable. Exposure to these agents can cause a variety of health issues, such as allergic and infectious diseases, neurological disorders, and cancer. Therefore, detecting and identifying bioaerosols is crucial, and bioaerosol sampling is a key step in any bioaerosol investigation. This review provides an overview of the current bioaerosol sampling methods, both passive and active, as well as their applications and limitations for rapid on-site monitoring. The challenges and trends for detecting airborne microorganisms using molecular and immunological methods are also discussed, along with a summary and outlook for the development of prompt monitoring technologies.

To provide information for 360-degree visual space exploration, we design experiments to measure and analyze object-centric visual preference. After defining the static and dynamic properties of the objects of interest, we collect real-shot 360-degree videos and synthesize computer-generated 360-degree videos so that the objects have different combinations of static and dynamic properties. From head movement trajectories of subjects wearing head-mounted displays and watching 360-degree videos, we compare visual preference between objects with different static and dynamic properties. The experimental results indicate that subjects have visual preference for certain static and dynamic properties of objects over others; with this knowledge we can construct visually salient viewports by detecting and comparing static and dynamic properties of objects in a 360-degree video.

ObjectiveDysfunction of the pelvic floor muscles (PFM) is associated with sexual dysfunction in women with stress urinary incontinence (SUI). The EasyK7 device was developed to stimulate the PFM by surface electrical stimulation during sitting (SESdS). We investigated the effects of SESdS on PFM function and sexual function in women with SUI.MethodsWomen with SUI were randomized into the SESdS and control groups. PFM function and sexual function were assessed using a perineometer and the pelvic organ prolapse–urinary incontinence sexual function questionnaire (PISQ), respectively. After 8 weeks, the groups were compared using either analysis of covariance with the baseline values as covariates or the paired Student's t-test.ResultsThe final analysis included 16 subjects from each group. There were significant differences between the SESdS and control groups after the intervention, as well as within the SESdS group between the pre- and post-intervention measurements. The P-values for the differences in PFM measurements between the groups, and between the pre- and post- intervention measurements within the SESdS group, were 0.001 and 0.004 for power, 0.015 and 0.011 for strength, and 0.012 and 0.034 for endurance, respectively. In addition, in the PISQ, there were significant differences between the groups and between the pre- and post-intervention measurements within the SESdS group in the partner-related domain (between groups: P=0.003; within SESdS group: P=0.024) and total score (between groups: P

The purpose of this study was to develop a vertical seismic isolation device essential for the three-dimensional seismic isolation design of nuclear power plant equipment. The vertical seismic isolation device in this study has a concept that can be integrally combined with a conventional laminated rubber bearing, a horizontal seismic isolator with a design vertical load of 10 kN. To develop the vertical seismic isolation device, the vertical spring and the seismic energy dissipation device capable of limiting the vertical displacement of the spring were designed and their performances were verified through actual tests. In this study, the target elevation of the floor is 136 ft, where safety-related nuclear equipment, such as cabinet and remote shutdown console, etc., is installed. The sensitivity studies were carried out to investigate the optimal design vertical isolation frequencies for the target building elevation. Based on the results of the sensitivity study, a disc spring and a helical coil spring were selected for the vertical stiffness design, and the steel damper was selected for the seismic energy dissipation, and their performance characteristics were tested to confirm the design performance. For the steel damper, three types were designed and their energy dissipation characteristics by hysteretic behavior were confirmed by the inelastic finite element analyses and the tests in static fully reversed cyclic conditions. Through the study of the vertical seismic isolation device, it was found that 2.5 Hz~3.0 Hz is appropriate for the optimal design vertical isolation. With results of the vertical seismic isolation performance analysis, the appropriate number of steel dampers are proposed to limit the vertical seismic displacement of the spring within the static displacement range by the design vertical load.