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8. Neoadjuvant chemotherapy for borderline resectable and upfront resectable pancreatic cancer increasing overall survival and disease-free survival?

Author

Fossaert, Violette, primary, Mimmo, Antonio, additional, Rhaiem, Rami, additional, Rached, Linda J., additional, Brasseur, Mathilde, additional, Brugel, Mathias, additional, Pegoraro, Francesca, additional, Sanchez, Stephane, additional, Bouché, Olivier, additional, Kianmanesh, Reza, additional, and Piardi, Tullio, additional more...

Published
2022
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13. Conversion during Minimally Invasive Left Pancreatectomy

Author

De Ponthaud, Charles, Nassar, Alexandra, Dokmak, Safi, Bertrand, Thibaud, De Martino, Julien, Pastier, Clément, Castel, Antoine, De Rosa, Raffaele, Boubaddi, Mehdi, Iben-Khayat, Abdallah, Giannone, Fabio, Jolly, Elsa, Garnier, Jonathan, Louis-Gaubert, Clément, Mazzotta, Alessandro D, André, Marie, Gagnière, Johan, Viennet, Manon, Souche, François-Régis, Kianmanesh, Reza, Lupinacci, Renato Micelli, Regimbeau, Jean-Marc, Paye, François, Addeo, Pietro, Laurent, Alexis, Vandermeulen, Morgan, Caiazzo, Robert, El Amrani, Mehdi, Tresallet, Christophe, Doussot, Alexandre, Brunel, Martin, Jouffret, Lionel, Pinto, Amandine, Valverde, Alain, Romero Vece, Rodolfo, Fara, Régis, Mahfouf, Samir, Darnis, Benjamin, Chamakhi, Amine, Thereaux, Jeremie, Lubrano, Jean, Girard, Edouard, Veziant, Julie, Birnbaum, David Jérémie, Danion, Jérôme, Corté, Helene, Zemour, Johanna, Piardi, Tullio, de Carbonnières, Anne, Ragot, Emilia, Zarzavadjian Le Bian, Alban, David, Patrice, Brunaud, Laurent, Lermite, Emilie, Chreim, Laura, Charlaix, Ana Lucia, Gugenheim, Jean, Schwarz, Lilian, Bigourdan, Jean Marc, Le Roy, Bertrand, Karam, Elias, Rhaiem, Rami, Fabre, Jean-Michel, Lequeu, Jean-Baptiste, Noirault, Marie, Ayav, Ahmet, Soubrane, Olivier, Regenet, Nicolas, Turrini, Olivier, Muscari, Fabrice, Pessaux, Patrick, Thébault, Baudouin, Laurent, Christophe, Sulpice, Laurent, Sauvanet, Alain, Fuks, David, Gaujoux, Sébastien, Talbi, Ghofran, Scesa, Jean Luc, Gailleton, Régis, Daskaliuk, Oktavian, Bensignor, Thierry, Goasguen, Nicolas, Kebir, Zakaria, Magallon, Cloe, Camerlo, Antoine, Bennani, Ali, Berkane, Salah, David, Marie, Lazaar, Hatim, Saint-Marc, Olivier, Baratte, Clément, Bihain, Florence, Leclerc, Julie, Peschaud, Frédérique, Dembinski, Jeanne, Sutter, Willy, Leourier, Pauline, Bougard, Marie, Sesmun, Evans, Turco, Célia, Heyd, Bruno, Marichez, Arthur, Chiche, Laurence, Mayet, Audrey, Badic, Bogdan, Lacroix, Coralie, Buc, Emmanuel, Aboukassem, Adnan, Marchese, Ugo, Tzedakis, Stylianos, Naveendran, Gaanan, Kuperas, Cyrille, Facy, Olivier, Abba, Julio, Chirica, Mircea, Bianchi, Giorgio, Cherif, Rim, Marcelle, Jérôme, Meurisse, Nicolas, De Roover, Arnaud, Piessen, Guillaume, Bonnin, Eloïse, Pattou, François, Zerbib, Philippe, Saudemont, Alain, Truant, Stéphanie, Christou, Niki, Taibi, Abdelkader, Labiad, Camélia, Moutardier, Vincent, Ansart, François, Bardol, Thomas, Iannelli, Antonio, Drai, Céline, Vix, Jean, Gouader, Amine, Vaillant, Jean Christophe, Rousseau, Géraldine, Faure, Jean Pierre, Mimmo, Antonio, Duval-Binet, Ambroise, Barreira Rodrigues, Samuel Dos Santos, Papet, Eloise, Pinson, Jean, Monge, Matthieu, Deyrat, Julie, Vuillermet, Cindy, Boullenois, Hortense, Deheppe, Jerome, Sauvanet, Pierre, Jeune, Florence, Bachellier, Philippe, Kock, Arne, Carrere, Nicolas, Maulat, Charlotte, Bucur, Petru, Salamé, Ephrem, Pegoraro, Francesca, Malgras, Brice, Karoui, Mehdi, Barra, Morgane, Tribillon, Ecoline, Palen, Anais, and Ewald, Jacques more...

Published
2025
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20. Prospective Evaluation of Intrahepatic Microscopic Occult Tumor Foci in Patients with Numerous Colorectal Liver Metastases.

Author

Vigano, Luca, Di Tommaso, Luca, Mimmo, Antonio, Sollai, Mauro, Cimino, Matteo, Donadon, Matteo, Roncalli, Massimo, and Torzilli, Guido

Subjects
LIVER metastasis, MAGNETIC resonance imaging, COMPUTED tomography
Abstract

Background: Patients with numerous colorectal liver metastases (CLM) have high risk of early recurrence after liver resection (LR). The presence of intrahepatic occult microscopic metastases missed by imaging has been hypothesized, but it has never been assessed by pathology analyses. Methods: All patients with > 10 CLM who underwent LR between September 2015 and September 2016 were considered. A large sample of liver without evidence of disease ("healthy liver") was taken from the resected specimen and sent to the pathologist. One mm-thick sections were analyzed. Any metastasis, undetected by preoperative and intraoperative imaging, but identified by the pathologist was classified as occult microscopic metastasis. Results: Ten patients were prospectively enrolled (median number of CLM n = 15). In a per-lesion analysis, the sensitivity of computed tomography and magnetic resonance imaging was 91 and 98% respectively. The pathology examination confirmed all the CLM. All patients had an adequate sample of "healthy liver" (median number of examined blocks per sample n = 14 [5–33]). No occult microscopic metastases were detected. After a median follow-up of 15 months, 5 patients were disease-free. Recurrence was hepatic and bilobar in all patients. Conclusions: Clinically relevant occult microscopic disease in patients with numerous CLM is excluded. These results support the indication to resection in such patients and exclude the need for de principe major hepatectomy to increase the completeness of surgery. [ABSTRACT FROM AUTHOR] more...

Published
2019
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22. Absence of Viable HCC in the Native Liver Is an Independent Protective Factor of Tumor Recurrence After Liver Transplantation

Author

Montalti, Roberto, primary, Mimmo, Antonio, additional, Rompianesi, Gianluca, additional, Di Gregorio, Carmela, additional, Serra, Valentina, additional, Cautero, Nicola, additional, Ballarin, Roberto, additional, Spaggiari, Mario, additional, Tarantino, Giuseppe, additional, D’Amico, Giuseppe, additional, De Santis, Mario, additional, De Pietri, Lesley, additional, Troisi, Roberto I., additional, Gerunda, Giorgio E., additional, and Di Benedetto, Fabrizio, additional more...

Published
2014
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24. Absence of viable HCC in the native liver is an independent protective factor of tumor recurrence after liver transplantation

Author

Mario Spaggiari, Giuseppe Tarantino, Giuseppe D'Amico, Giorgio Enrico Gerunda, Lesley De Pietri, Roberto Ballarin, A. Mimmo, Valentina Serra, Roberto Montalti, Roberto Troisi, Gianluca Rompianesi, Carmela Di Gregorio, Nicola Cautero, Mario De Santis, Fabrizio Di Benedetto, Montalti, Roberto, Mimmo, Antonio, Rompianesi, Gianluca, Di Gregorio, Carmela, Serra, Valentina, Cautero, Nicola, Ballarin, Roberto, Spaggiari, Mario, Tarantino, Giuseppe, D'Amico, Giuseppe, De Santis, Mario, De Pietri, Lesley, Troisi, Roberto I, Gerunda, Giorgio E, and Di Benedetto, Fabrizio more...

Subjects
Adult, Male, Sorafenib, medicine.medical_specialty, Carcinoma, Hepatocellular, Cirrhosis, Radiofrequency ablation, medicine.medical_treatment, Liver transplantation, Gastroenterology, law.invention, law, Internal medicine, medicine, HCC, liver transplantation, Humans, Multivariate Analysi, Aged, Transplantation, business.industry, Liver Neoplasms, Multimodal therapy, Odds ratio, Middle Aged, medicine.disease, digestive system diseases, Liver Transplantation, Liver Neoplasm, Hepatocellular carcinoma, Multivariate Analysis, Female, Neoplasm Recurrence, Local, Percutaneous ethanol injection, business, Human, medicine.drug
Abstract

Background: Prognostic factors for hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) are still a matter of debate. The absence of viable tumor in the native liver, due to effectiveness of pre-LT locoregional treatment or liver resection, is an intriguing prognostic factor that had never been evaluated. Methods: Between November 2000 and December 2011, 210 LTs were performed in patients with evidence of HCC and cirrhosis. Results: Fifty-three (25.2%) patients did not show any evidence of active residual HCC in the native liver (Group NVH), whereas 157 (74.8%) patients showed viable HCC (Group VH). All patients in Group NVH were treated before LT with a multimodal approach combining transarterial chemoembolization, liver resection, radiofrequency ablation, percutaneous ethanol injection, or sorafenib, whereas, in Group VH, 110 of the 157 (70.1%) patients received bridging therapy (P more...

Published
2014

25. Early use of mammalian target of rapamycin inhibitors is an independent risk factor for incisional hernia development after liver transplantation

Author

Roberto, Montalti, Antonio, Mimmo, Gianluca, Rompianesi, Valentina, Serra, Nicola, Cautero, Roberto, Ballarin, Nicola, De Ruvo, Robert, Cunningham Gerring, Giorgio, Enrico Gerunda, Fabrizio, Di Benedetto, Montalti, Roberto, Mimmo, Antonio, Rompianesi, Gianluca, Serra, Valentina, Cautero, Nicola, Ballarin, Roberto, De Ruvo, Nicola, Cunningham Gerring, Robert, Enrico Gerunda, Giorgio, and Di Benedetto, Fabrizio more...

Subjects
Male, Hernia, Time Factors, Logistic Model, Time Factor, Sex Factor, Kaplan-Meier Estimate, Risk Assessment, Immunosuppressive Agent, adverse effects/mortality, Sex Factors, Retrospective Studie, Risk Factors, Odds Ratio, Humans, Abdominal, Multivariate Analysi, Retrospective Studies, antagonists /&/ inhibitors, Chi-Square Distribution, TOR Serine-Threonine Kinase, Risk Factor, Chi-Square Distribution, Female, Hernia, etiology/mortality, Humans, Immunosuppressive Agents, adverse effects, Italy, Kaplan-Meier Estimate, Liver Transplantation, adverse effects/mortality, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Retrospective Studies, Risk Assessment, Risk Factors, Sex Factors, TOR Serine-Threonine Kinases, antagonists /&/ inhibitors, Time Factors, Treatment Outcome, TOR Serine-Threonine Kinases, Middle Aged, etiology/mortality, Hernia, Abdominal, Liver Transplantation, Logistic Models, Treatment Outcome, Italy, Multivariate Analysis, adverse effects, Female, Immunosuppressive Agents, Human
Abstract

Incisional hernias (IHs) are common complications after liver transplantation (LT) with a reported incidence of 1.7% to 34.3%. The purpose of this retrospective study was to evaluate the risk factors for IH development after LT with a focus on the role of immunosuppressive therapy during the first month after LT. We analyzed 373 patients who underwent LT and divided them into 2 groups according to their postoperative course: an IH group (121 patients or 32.4%) and a no-IH group (252 patients or 67.6%). A univariate analysis demonstrated that the following were risk factors related to IH development: male sex (P = 0.03), a body mass index ≥ 29 kg/m(2) (P = 0.005), LT after 2004 (P = 0.02), a Model for End-Stage Liver Disease (MELD) score ≥ 22 (P = 0.01), and hepatitis B virus infection (P = 0.01). The highest incidence of IHs was found in patients treated with mammalian target of rapamycin (mTOR) inhibitors (54.5%, P = 0.004). A multivariate analysis revealed male sex (P = 0.03), a pretransplant MELD score ≥ 22 (P = 0.04), and the use of mTOR inhibitors (P = 0.001) to be independent risk factors for IHs after LT. In conclusion, immunosuppressive therapy with mTOR inhibitors is an important independent risk factor for IH development after LT. To reduce the incidence of IHs, mTOR inhibitors should be avoided until the fourth month after LT unless their use is deemed to be strictly necessary. more...

Published
2012