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45 results on '"Mima, Atsushi"'

1. Anti-integrin αvβ6 autoantibodies in patients with primary sclerosing cholangitis

Author

Yoshida, Hiroyuki, Shiokawa, Masahiro, Kuwada, Takeshi, Muramoto, Yuya, Ota, Sakiko, Nishikawa, Yoshihiro, Maeda, Hirona, Kakiuchi, Nobuyuki, Okamoto, Kanako, Yamazaki, Hajime, Yokode, Masataka, Nakamura, Takeharu, Matsumoto, Shimpei, Hirano, Tomonori, Okada, Hirokazu, Marui, Saiko, Sogabe, Yuko, Matsumori, Tomoaki, Mima, Atsushi, Uza, Norimitsu, Eso, Yuji, Takai, Atsushi, Takahashi, Ken, Ueda, Yoshihide, Kodama, Yuzo, Chiba, Tsutomu, and Seno, Hiroshi

Published
2023
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2. Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development

Author

Kuriyama, Katsutoshi, Kodama, Yuzo, Shiokawa, Masahiro, Nishikawa, Yoshihiro, Marui, Saiko, Kuwada, Takeshi, Sogabe, Yuko, Kakiuchi, Nobuyuki, Tomono, Teruko, Matsumori, Tomoaki, Mima, Atsushi, Morita, Toshihiro, Ueda, Tatsuki, Tsuda, Motoyuki, Yamauchi, Yuki, Sakuma, Yojiro, Ota, Yuji, Maruno, Takahisa, Uza, Norimitsu, Kageyama, Ryoichiro, Chiba, Tsutomu, and Seno, Hiroshi

Published
2021
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3. Prospective study of early chronic pancreatitis diagnosed based on the Japanese diagnostic criteria

Author

Masamune, Atsushi, Nabeshima, Tatsuhide, Kikuta, Kazuhiro, Hamada, Shin, Nakano, Eriko, Kume, Kiyoshi, Kanno, Atsushi, Sato, Ai, Tachibana, Yuichi, Inatomi, Osamu, Yamamoto, Satoshi, Ikeura, Tsukasa, Futagami, Seiji, Taguchi, Masashi, Hanada, Keiji, Shimizu, Kyoko, Kageoka, Masanobu, Saito, Tomotaka, Eguchi, Takaaki, Kubota, Kensuke, Takenaka, Mamoru, Mima, Atsushi, Irisawa, Atsushi, Ito, Tetsuhide, Andoh, Akira, Inui, Kazuo, Takeyama, Yoshifumi, Yamaue, Hiroki, Okazaki, Kazuichi, and Shimosegawa, Tooru

Published
2019
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4. Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis

Author

Nishikawa, Yoshihiro, Kodama, Yuzo, Shiokawa, Masahiro, Matsumori, Tomoaki, Marui, Saiko, Kuriyama, Katsutoshi, Kuwada, Takeshi, Sogabe, Yuko, Kakiuchi, Nobuyuki, Tomono, Teruko, Mima, Atsushi, Morita, Toshihiro, Ueda, Tatsuki, Tsuda, Motoyuki, Yamauchi, Yuki, Sakuma, Yojiro, Ota, Yuji, Maruno, Takahisa, Uza, Norimitsu, Uesugi, Motonari, Kageyama, Ryoichiro, Chiba, Tsutomu, and Seno, Hiroshi

Published
2019
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5. Effect of remote ischemia or nicorandil on myocardial injury following percutaneous coronary intervention in patients with stable coronary artery disease: A randomized controlled trial

Author

Miyoshi, Toru, Ejiri, Kentaro, Kohno, Kunihisa, Nakahama, Makoto, Doi, Masayuki, Munemasa, Mitsuru, Murakami, Masaaki, Takaishi, Atsushi, Kawai, Yusuke, Sato, Tetsuya, Sato, Katsumasa, Oka, Takefumi, Takahashi, Natsuki, Sakuragi, Satoru, Mima, Atsushi, Enko, Kenki, Hosogi, Shingo, Nanba, Seiji, Hirami, Ryoichi, Nakamura, Kazufumi, and Ito, Hiroshi

Published
2017
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6. Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model

Author

Ito, Ryo, primary, Kimura, Azuma, additional, Hirose, Yurie, additional, Hatano, Yu, additional, Mima, Atsushi, additional, Mae, Shin-Ichi, additional, Keidai, Yamato, additional, Nakamura, Toshihiro, additional, Fujikura, Junji, additional, Nishi, Yohei, additional, Ohta, Akira, additional, Toyoda, Taro, additional, Inagaki, Nobuya, additional, and Osafune, Kenji, additional

Published
2023
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7. Data from Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors

Author

Yamauchi, Yuki, primary, Kodama, Yuzo, primary, Shiokawa, Masahiro, primary, Kakiuchi, Nobuyuki, primary, Marui, Saiko, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Morita, Toshihiro, primary, Matsumori, Tomoaki, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Nishikawa, Yoshihiro, primary, Kuriyama, Katsutoshi, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Masuda, Atsuhiro, primary, Tatsuoka, Hisato, primary, Yabe, Daisuke, primary, Minamiguchi, Sachiko, primary, Masui, Toshihiko, primary, Inagaki, Nobuya, primary, Uemoto, Shinji, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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8. Data from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma

Author

Morita, Toshihiro, primary, Kodama, Yuzo, primary, Shiokawa, Masahiro, primary, Kuriyama, Katsutoshi, primary, Marui, Saiko, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Matsumori, Tomoaki, primary, Kakiuchi, Nobuyuki, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Yamauchi, Yuki, primary, Nishikawa, Yoshihiro, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Nagasawa, Takashi, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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9. Supplementary Data from Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma

Author

Matsumori, Tomoaki, primary, Kodama, Yuzo, primary, Takai, Atsushi, primary, Shiokawa, Masahiro, primary, Nishikawa, Yoshihiro, primary, Matsumoto, Tomonori, primary, Takeda, Haruhiko, primary, Marui, Saiko, primary, Okada, Hirokazu, primary, Hirano, Tomonori, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Kakiuchi, Nobuyuki, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Morita, Toshihiro, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Yamauchi, Yuki, primary, Kuriyama, Katsutoshi, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Marusawa, Hiroyuki, primary, Kageyama, Ryoichiro, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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10. Figure S1 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma

Author

Morita, Toshihiro, primary, Kodama, Yuzo, primary, Shiokawa, Masahiro, primary, Kuriyama, Katsutoshi, primary, Marui, Saiko, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Matsumori, Tomoaki, primary, Kakiuchi, Nobuyuki, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Yamauchi, Yuki, primary, Nishikawa, Yoshihiro, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Nagasawa, Takashi, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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11. Table. S4 from Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma

Author

Matsumori, Tomoaki, primary, Kodama, Yuzo, primary, Takai, Atsushi, primary, Shiokawa, Masahiro, primary, Nishikawa, Yoshihiro, primary, Matsumoto, Tomonori, primary, Takeda, Haruhiko, primary, Marui, Saiko, primary, Okada, Hirokazu, primary, Hirano, Tomonori, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Kakiuchi, Nobuyuki, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Morita, Toshihiro, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Yamauchi, Yuki, primary, Kuriyama, Katsutoshi, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Marusawa, Hiroyuki, primary, Kageyama, Ryoichiro, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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12. Data from Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma

Author

Matsumori, Tomoaki, primary, Kodama, Yuzo, primary, Takai, Atsushi, primary, Shiokawa, Masahiro, primary, Nishikawa, Yoshihiro, primary, Matsumoto, Tomonori, primary, Takeda, Haruhiko, primary, Marui, Saiko, primary, Okada, Hirokazu, primary, Hirano, Tomonori, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Kakiuchi, Nobuyuki, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Morita, Toshihiro, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Yamauchi, Yuki, primary, Kuriyama, Katsutoshi, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Marusawa, Hiroyuki, primary, Kageyama, Ryoichiro, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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13. Table S1-3 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma

Author

Morita, Toshihiro, primary, Kodama, Yuzo, primary, Shiokawa, Masahiro, primary, Kuriyama, Katsutoshi, primary, Marui, Saiko, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Matsumori, Tomoaki, primary, Kakiuchi, Nobuyuki, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Yamauchi, Yuki, primary, Nishikawa, Yoshihiro, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Nagasawa, Takashi, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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14. Fig. S4 from Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma

Author

Matsumori, Tomoaki, primary, Kodama, Yuzo, primary, Takai, Atsushi, primary, Shiokawa, Masahiro, primary, Nishikawa, Yoshihiro, primary, Matsumoto, Tomonori, primary, Takeda, Haruhiko, primary, Marui, Saiko, primary, Okada, Hirokazu, primary, Hirano, Tomonori, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Kakiuchi, Nobuyuki, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Morita, Toshihiro, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Yamauchi, Yuki, primary, Kuriyama, Katsutoshi, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Marusawa, Hiroyuki, primary, Kageyama, Ryoichiro, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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15. Supplementary Data from Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors

Author

Yamauchi, Yuki, primary, Kodama, Yuzo, primary, Shiokawa, Masahiro, primary, Kakiuchi, Nobuyuki, primary, Marui, Saiko, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Morita, Toshihiro, primary, Matsumori, Tomoaki, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Nishikawa, Yoshihiro, primary, Kuriyama, Katsutoshi, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Masuda, Atsuhiro, primary, Tatsuoka, Hisato, primary, Yabe, Daisuke, primary, Minamiguchi, Sachiko, primary, Masui, Toshihiko, primary, Inagaki, Nobuya, primary, Uemoto, Shinji, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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16. Supplemental Legends from Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors

Author

Yamauchi, Yuki, primary, Kodama, Yuzo, primary, Shiokawa, Masahiro, primary, Kakiuchi, Nobuyuki, primary, Marui, Saiko, primary, Kuwada, Takeshi, primary, Sogabe, Yuko, primary, Tomono, Teruko, primary, Mima, Atsushi, primary, Morita, Toshihiro, primary, Matsumori, Tomoaki, primary, Ueda, Tatsuki, primary, Tsuda, Motoyuki, primary, Nishikawa, Yoshihiro, primary, Kuriyama, Katsutoshi, primary, Sakuma, Yojiro, primary, Ota, Yuji, primary, Maruno, Takahisa, primary, Uza, Norimitsu, primary, Masuda, Atsuhiro, primary, Tatsuoka, Hisato, primary, Yabe, Daisuke, primary, Minamiguchi, Sachiko, primary, Masui, Toshihiko, primary, Inagaki, Nobuya, primary, Uemoto, Shinji, primary, Chiba, Tsutomu, primary, and Seno, Hiroshi, primary

Published
2023
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Author

50737880, 80802785, 90839721, 90836032, 30447958, 80760587, 60594372, 90335266, Yoshida, Hiroyuki, Shiokawa, Masahiro, Kuwada, Takeshi, Muramoto, Yuya, Ota, Sakiko, Nishikawa, Yoshihiro, Maeda, Hirona, Kakiuchi, Nobuyuki, Okamoto, Kanako, Yamazaki, Hajime, Yokode, Masataka, Nakamura, Takeharu, Matsumoto, Shimpei, Hirano, Tomonori, Okada, Hirokazu, Marui, Saiko, Sogabe, Yuko, Matsumori, Tomoaki, Mima, Atsushi, Uza, Norimitsu, Eso, Yuji, Takai, Atsushi, Takahashi, Ken, Ueda, Yoshihide, Kodama, Yuzo, Chiba, Tsutomu, Seno, Hiroshi, 50737880, 80802785, 90839721, 90836032, 30447958, 80760587, 60594372, 90335266, Yoshida, Hiroyuki, Shiokawa, Masahiro, Kuwada, Takeshi, Muramoto, Yuya, Ota, Sakiko, Nishikawa, Yoshihiro, Maeda, Hirona, Kakiuchi, Nobuyuki, Okamoto, Kanako, Yamazaki, Hajime, Yokode, Masataka, Nakamura, Takeharu, Matsumoto, Shimpei, Hirano, Tomonori, Okada, Hirokazu, Marui, Saiko, Sogabe, Yuko, Matsumori, Tomoaki, Mima, Atsushi, Uza, Norimitsu, Eso, Yuji, Takai, Atsushi, Takahashi, Ken, Ueda, Yoshihide, Kodama, Yuzo, Chiba, Tsutomu, and Seno, Hiroshi

Published
2023

18. Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model

Author

70378743, 60593530, 80502947, Ito, Ryo, Kimura, Azuma, Hirose, Yurie, Hatano, Yu, Mima, Atsushi, Mae, Shin-Ichi, Keidai, Yamato, Nakamura, Toshihiro, Fujikura, Junji, Nishi, Yohei, Ohta, Akira, Toyoda, Taro, Inagaki, Nobuya, Osafune, Kenji, 70378743, 60593530, 80502947, Ito, Ryo, Kimura, Azuma, Hirose, Yurie, Hatano, Yu, Mima, Atsushi, Mae, Shin-Ichi, Keidai, Yamato, Nakamura, Toshihiro, Fujikura, Junji, Nishi, Yohei, Ohta, Akira, Toyoda, Taro, Inagaki, Nobuya, and Osafune, Kenji

Abstract

For pluripotent stem cell (PSC)-based regenerative therapy against diabetes, the differentiation efficiency to pancreatic lineage cells needs to be improved based on the mechanistic understanding of pancreatic differentiation. Here, we aimed to elucidate the molecular mechanisms underlying pancreatic endoderm differentiation by searching for factors that regulate a crucial pancreatic endoderm marker gene, NKX6.1. Unbiasedly screening an siRNA knockdown library, we identified a candidate transcription factor, HHEX. HHEX knockdown suppressed the expression of another pancreatic endoderm marker gene, PTF1A, as well as NKX6.1, independently of PDX1, a known regulator of NKX6.1 expression. In contrast, the overexpression of HHEX upregulated the expressions of NKX6.1 and PTF1A. RNA-seq analysis showed decreased expressions of several genes related to pancreatic development, such as NKX6.1, PTF1A, ONECUT1 and ONECUT3, in HHEX knockdown pancreatic endoderm. These results suggest that HHEX plays a key role in pancreatic endoderm differentiation.

Published
2023

19. Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice

Author

Sakuma, Yojiro, Kodama, Yuzo, Eguchi, Takaaki, Uza, Norimitsu, Tsuji, Yoshihisa, Shiokawa, Masahiro, Maruno, Takahisa, Kuriyama, Katsutoshi, Nishikawa, Yoshihiro, Yamauchi, Yuki, Tsuda, Motoyuki, Ueda, Tatsuki, Matsumori, Tomoaki, Morita, Toshihiro, Tomono, Teruko, Kakiuchi, Nobuyuki, Mima, Atsushi, Sogabe, Yuko, Marui, Saiko, Kuwada, Takeshi, Okada, Akihiko, Watanabe, Tomohiro, Nakase, Hiroshi, Chiba, Tsutomu, and Seno, Hiroshi

Published
2018
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20. Correction: CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma

Author

Morita, Toshihiro, primary, Kodama, Yuzo, additional, Shiokawa, Masahiro, additional, Kuriyama, Katsutoshi, additional, Marui, Saiko, additional, Kuwada, Takeshi, additional, Sogabe, Yuko, additional, Matsumori, Tomoaki, additional, Kakiuchi, Nobuyuki, additional, Tomono, Teruko, additional, Mima, Atsushi, additional, Ueda, Tatsuki, additional, Tsuda, Motoyuki, additional, Yamauchi, Yuki, additional, Nishikawa, Yoshihiro, additional, Sakuma, Yojiro, additional, Ota, Yuji, additional, Maruno, Takahisa, additional, Uza, Norimitsu, additional, Nagasawa, Takashi, additional, Chiba, Tsutomu, additional, and Seno, Hiroshi, additional

Published
2021
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21. Identification of an Anti–Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis

Author

Kuwada, Takeshi, primary, Shiokawa, Masahiro, additional, Kodama, Yuzo, additional, Ota, Sakiko, additional, Kakiuchi, Nobuyuki, additional, Nannya, Yasuhito, additional, Yamazaki, Hajime, additional, Yoshida, Hiroyuki, additional, Nakamura, Takeharu, additional, Matsumoto, Shimpei, additional, Muramoto, Yuya, additional, Yamamoto, Shuji, additional, Honzawa, Yusuke, additional, Kuriyama, Katsutoshi, additional, Okamoto, Kanako, additional, Hirano, Tomonori, additional, Okada, Hirokazu, additional, Marui, Saiko, additional, Sogabe, Yuko, additional, Morita, Toshihiro, additional, Matsumori, Tomoaki, additional, Mima, Atsushi, additional, Nishikawa, Yoshihiro, additional, Ueda, Tatsuki, additional, Matsumura, Kazuyoshi, additional, Uza, Norimitsu, additional, Chiba, Tsutomu, additional, and Seno, Hiroshi, additional

Published
2021
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22. This title is unavailable for guests, please login to see more information.

Author

50737880, 90839721, 60451811, 90836032, 00789638, 80802785, 30447958, 90335266, Kuwada, Takeshi, Shiokawa, Masahiro, Kodama, Yuzo, Ota, Sakiko, Kakiuchi, Nobuyuki, Nannya, Yasuhito, Yamazaki, Hajime, Yoshida, Hiroyuki, Nakamura, Takeharu, Matsumoto, Shimpei, Muramoto, Yuya, Yamamoto, Shuji, Honzawa, Yusuke, Kuriyama, Katsutoshi, Okamoto, Kanako, Hirano, Tomonori, Okada, Hirokazu, Marui, Saiko, Sogabe, Yuko, Morita, Toshihiro, Matsumori, Tomoaki, Mima, Atsushi, Nishikawa, Yoshihiro, Ueda, Tatsuki, Matsumura, Kazuyoshi, Uza, Norimitsu, Chiba, Tsutomu, Seno, Hiroshi, 50737880, 90839721, 60451811, 90836032, 00789638, 80802785, 30447958, 90335266, Kuwada, Takeshi, Shiokawa, Masahiro, Kodama, Yuzo, Ota, Sakiko, Kakiuchi, Nobuyuki, Nannya, Yasuhito, Yamazaki, Hajime, Yoshida, Hiroyuki, Nakamura, Takeharu, Matsumoto, Shimpei, Muramoto, Yuya, Yamamoto, Shuji, Honzawa, Yusuke, Kuriyama, Katsutoshi, Okamoto, Kanako, Hirano, Tomonori, Okada, Hirokazu, Marui, Saiko, Sogabe, Yuko, Morita, Toshihiro, Matsumori, Tomoaki, Mima, Atsushi, Nishikawa, Yoshihiro, Ueda, Tatsuki, Matsumura, Kazuyoshi, Uza, Norimitsu, Chiba, Tsutomu, and Seno, Hiroshi

Published
2021

23. Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma

Author

Matsumori, Tomoaki, primary, Kodama, Yuzo, additional, Takai, Atsushi, additional, Shiokawa, Masahiro, additional, Nishikawa, Yoshihiro, additional, Matsumoto, Tomonori, additional, Takeda, Haruhiko, additional, Marui, Saiko, additional, Okada, Hirokazu, additional, Hirano, Tomonori, additional, Kuwada, Takeshi, additional, Sogabe, Yuko, additional, Kakiuchi, Nobuyuki, additional, Tomono, Teruko, additional, Mima, Atsushi, additional, Morita, Toshihiro, additional, Ueda, Tatsuki, additional, Tsuda, Motoyuki, additional, Yamauchi, Yuki, additional, Kuriyama, Katsutoshi, additional, Sakuma, Yojiro, additional, Ota, Yuji, additional, Maruno, Takahisa, additional, Uza, Norimitsu, additional, Marusawa, Hiroyuki, additional, Kageyama, Ryoichiro, additional, Chiba, Tsutomu, additional, and Seno, Hiroshi, additional

Published
2020
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24. CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma

Author

Morita, Toshihiro, primary, Kodama, Yuzo, additional, Shiokawa, Masahiro, additional, Kuriyama, Katsutoshi, additional, Marui, Saiko, additional, Kuwada, Takeshi, additional, Sogabe, Yuko, additional, Matsumori, Tomoaki, additional, Kakiuchi, Nobuyuki, additional, Tomono, Teruko, additional, Mima, Atsushi, additional, Ueda, Tatsuki, additional, Tsuda, Motoyuki, additional, Yamauchi, Yuki, additional, Nishikawa, Yoshihiro, additional, Sakuma, Yojiro, additional, Ota, Yuji, additional, Maruno, Takahisa, additional, Uza, Norimitsu, additional, Nagasawa, Takashi, additional, Chiba, Tsutomu, additional, and Seno, Hiroshi, additional

Published
2020
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25. A novel technique for mapping biopsy of bile duct cancer

Author

Okada, Hirokazu, additional, Uza, Norimitsu, additional, Matsumori, Tomoaki, additional, Matsumoto, Shimpei, additional, Muramoto, Yuya, additional, Ota, Sakiko, additional, Nakamura, Takeharu, additional, Yoshida, Hiroyuki, additional, Hirano, Tomonori, additional, Kuwada, Takeshi, additional, Marui, Saiko, additional, Sogabe, Yuko, additional, Morita, Toshihiro, additional, Kakiuchi, Nobuyuki, additional, Mima, Atsushi, additional, Ueda, Tatsuki, additional, Nishikawa, Yoshihiro, additional, Tsuda, Motoyuki, additional, Maruno, Takahisa, additional, Shiokawa, Masahiro, additional, Takahashi, Ken, additional, Taura, Kojiro, additional, Minamiguchi, Sachiko, additional, Kodama, Yuzo, additional, and Seno, Hiroshi, additional

Published
2020
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26. Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors

Author

Yamauchi, Yuki, primary, Kodama, Yuzo, additional, Shiokawa, Masahiro, additional, Kakiuchi, Nobuyuki, additional, Marui, Saiko, additional, Kuwada, Takeshi, additional, Sogabe, Yuko, additional, Tomono, Teruko, additional, Mima, Atsushi, additional, Morita, Toshihiro, additional, Matsumori, Tomoaki, additional, Ueda, Tatsuki, additional, Tsuda, Motoyuki, additional, Nishikawa, Yoshihiro, additional, Kuriyama, Katsutoshi, additional, Sakuma, Yojiro, additional, Ota, Yuji, additional, Maruno, Takahisa, additional, Uza, Norimitsu, additional, Masuda, Atsuhiro, additional, Tatsuoka, Hisato, additional, Yabe, Daisuke, additional, Minamiguchi, Sachiko, additional, Masui, Toshihiko, additional, Inagaki, Nobuya, additional, Uemoto, Shinji, additional, Chiba, Tsutomu, additional, and Seno, Hiroshi, additional

Published
2020
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27. A novel technique for mapping biopsy of bile duct cancer.

Author

Okada, Hirokazu, Uza, Norimitsu, Matsumori, Tomoaki, Matsumoto, Shimpei, Muramoto, Yuya, Ota, Sakiko, Nakamura, Takeharu, Yoshida, Hiroyuki, Hirano, Tomonori, Kuwada, Takeshi, Marui, Saiko, Sogabe, Yuko, Morita, Toshihiro, Kakiuchi, Nobuyuki, Mima, Atsushi, Ueda, Tatsuki, Nishikawa, Yoshihiro, Tsuda, Motoyuki, Maruno, Takahisa, and Shiokawa, Masahiro

Subjects
CHOLANGIOCARCINOMA, INTRAHEPATIC bile ducts, BIOPSY, BILE duct tumors, ENDOSCOPIC retrograde cholangiopancreatography, BILE ducts
Abstract

BACKGROUND : Accurate preoperative assessment of the longitudinal extension of perihilar cholangiocarcinoma (PHCC) is essential for treatment planning. Mapping biopsies for PHCC remain challenging owing to technical difficulties and insufficient sample amounts. The aim of this study was to investigate the usefulness of a novel technique for mapping biopsies of PHCC. METHODS : Our novel method focused on a biliary stent delivery system for mapping biopsies. Fifty patients with PHCC undergoing endoscopic transpapillary mapping biopsy using the novel method were reviewed from August 2015 to June 2019. RESULTS : The median number of biopsy samples was six (range 1 - 17), and the rate of adequate sampling was 91.4 % (266 /291). Biopsy from the intrahepatic bile duct was possible in 82.0 % of patients (41 /50), and negative margins were confirmed in the resected specimens from 34 /39 patients who underwent surgery (87.2 %). None of the patients had post-endoscopic retrograde cholangiopancreatography pancreatitis. CONCLUSIONS : With our novel method, accurate assessment of the longitudinal extension of PHCC might be expected with minimal trauma to the duodenal papilla. [ABSTRACT FROM AUTHOR]

Published
2021
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28. Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice

Author

30447958, 50737880, 40760567, 80802785, 90839721, 90335266, Sakuma, Yojiro, Kodama, Yuzo, Eguchi, Takaaki, Uza, Norimitsu, Tsuji, Yoshihisa, Shiokawa, Masahiro, Maruno, Takahisa, Kuriyama, Katsutoshi, Nishikawa, Yoshihiro, Yamauchi, Yuki, Tsuda, Motoyuki, Ueda, Tatsuki, Matsumori, Tomoaki, Morita, Toshihiro, Tomono, Teruko, Kakiuchi, Nobuyuki, Mima, Atsushi, Sogabe, Yuko, Marui, Saiko, Kuwada, Takeshi, Okada, Akihiko, Watanabe, Tomohiro, Nakase, Hiroshi, Chiba, Tsutomu, Seno, Hiroshi, 30447958, 50737880, 40760567, 80802785, 90839721, 90335266, Sakuma, Yojiro, Kodama, Yuzo, Eguchi, Takaaki, Uza, Norimitsu, Tsuji, Yoshihisa, Shiokawa, Masahiro, Maruno, Takahisa, Kuriyama, Katsutoshi, Nishikawa, Yoshihiro, Yamauchi, Yuki, Tsuda, Motoyuki, Ueda, Tatsuki, Matsumori, Tomoaki, Morita, Toshihiro, Tomono, Teruko, Kakiuchi, Nobuyuki, Mima, Atsushi, Sogabe, Yuko, Marui, Saiko, Kuwada, Takeshi, Okada, Akihiko, Watanabe, Tomohiro, Nakase, Hiroshi, Chiba, Tsutomu, and Seno, Hiroshi

Abstract

Severe acute pancreatitis is a lethal inflammatory disease frequently accompanied by pancreatic necrosis. We aimed to identify a key regulator in the development of pancreatic necrosis. A cytokine/chemokine array using sera from patients with acute pancreatitis (AP) revealed that serum CXCL16 levels were elevated according to the severity of pancreatitis. In a mouse model of AP, Cxcl16 expression was induced in pancreatic acini in the late phase with the development of pancreatic necrosis. Cxcl16⁻/⁻ mice revealed similar sensitivity as wild-type (WT) mice to the onset of pancreatitis, but better resisted development of acinar cell necrosis with attenuated neutrophil infiltration. A cytokine array and immunohistochemistry revealed lower expression of Ccl9, a neutrophil chemoattractant, in the pancreatic acini of Cxcl16⁻/⁻ mice than WT mice. Ccl9 mRNA expression was induced by stimulation with Cxcl16 protein in pancreatic acinar cells in vitro, suggesting a Cxcl16/Ccl9 cascade. Neutralizing antibody against Cxcl16 ameliorated pancreatic injury in the mouse AP model with decreased Ccl9 expression and less neutrophil accumulation. In conclusion, Cxcl16 expressed in pancreatic acini contributes to the development of acinar cell necrosis through the induction of Ccl9 and subsequent neutrophil infiltration. CXCL16 could be a new therapeutic target in AP.

Published
2018

29. Laminin 511 is a target antigen in autoimmune pancreatitis

Author

Shiokawa, Masahiro, primary, Kodama, Yuzo, additional, Sekiguchi, Kiyotoshi, additional, Kuwada, Takeshi, additional, Tomono, Teruko, additional, Kuriyama, Katsutoshi, additional, Yamazaki, Hajime, additional, Morita, Toshihiro, additional, Marui, Saiko, additional, Sogabe, Yuko, additional, Kakiuchi, Nobuyuki, additional, Matsumori, Tomoaki, additional, Mima, Atsushi, additional, Nishikawa, Yoshihiro, additional, Ueda, Tatsuki, additional, Tsuda, Motoyuki, additional, Yamauchi, Yuki, additional, Sakuma, Yojiro, additional, Maruno, Takahisa, additional, Uza, Norimitsu, additional, Tsuruyama, Tatsuaki, additional, Mimori, Tsuneyo, additional, Seno, Hiroshi, additional, and Chiba, Tsutomu, additional

Published
2018
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31. Su1325 - A Novel Anti-Tumorigenic Role of Cxcl12/Cxcr4 Signaling in Pancreatic Cancer Development via Shh Expression

Author

Morita, Toshihiro, primary, Kodama, Yuzo, additional, Seno, Hiroshi, additional, Uza, Norimitsu, additional, Shiokawa, Masahiro, additional, Maruno, Takahisa, additional, Tsuda, Motoyuki, additional, Ueda, Tatsuki, additional, Nishikawa, Yoshihiro, additional, Yamauchi, Yuki, additional, Matsumori, Tomoaki, additional, Kakiuchi, Nobuyuki, additional, Tomono, Teruko, additional, Mima, Atsushi, additional, Kuwada, Takeshi, additional, Marui, Saiko, additional, Sogabe, Yuko, additional, Okada, Hirokazu, additional, Hirano, Tomonori, additional, Sakuma, Yojiro, additional, and Kuriyama, Katsutoshi, additional

Published
2018
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33. Distinctive Role of RB and P53 in the Development of Pancreatic Neuroendocrine Tumors

Author

Yamauchi, Yuki, primary, Kodama, Yuzo, additional, Sogabe, Yuko, additional, Kuwada, Takeshi, additional, Marui, Saiko, additional, Mima, Atsushi, additional, Tomono, Teruko, additional, Morita, Toshihiro, additional, Kakiuchi, Nobuyuki, additional, Matsumori, Tomoaki, additional, Nishikawa, Yoshihiro, additional, Ueda, Tatsuki, additional, Tsuda, Motoyuki, additional, Kuriyama, Katsutoshi, additional, Sakuma, Yojiro, additional, Maruno, Takahisa, additional, Shiokawa, Masahiro, additional, Uza, Norimitsu, additional, and Seno, Hiroshi, additional

Published
2017
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34. Comparable effect of aliskiren or a diuretic added on an angiotensin II receptor blocker on augmentation index in hypertension: a multicentre, prospective, randomised study

Author

Miyoshi, Toru, primary, Murakami, Takashi, additional, Sakuragi, Satoru, additional, Doi, Masayuki, additional, Nanba, Seiji, additional, Mima, Atsushi, additional, Tominaga, Youkou, additional, Oka, Takafumi, additional, Kajikawa, Yutaka, additional, Nakamura, Kazufumi, additional, and Ito, Hiroshi, additional

Published
2017
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36. 691 Biphasic Role of HES1 in Pancreatic Development

Author

Kuriyama, Katsutoshi, primary, Kodama, Yuzo, additional, Shiokawa, Masahiro, additional, Kakiuchi, Nobuyuki, additional, Matsumori, Tomoaki, additional, Mima, Atsushi, additional, Tomono, Teruko, additional, Nishikawa, Yoshihiro, additional, Tsuda, Motoyuki, additional, Ueda, Tatsuki, additional, Yamauchi, Yuki, additional, Sakuma, Yojiro, additional, Ota, Yuji, additional, Maruno, Takahisa, additional, Uza, Norimitsu, additional, Seno, Hiroshi, additional, and Chiba, Tsutomu, additional

Published
2016
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37. Sa1481 Chemokine CXCL16 Plays a Critical Role in the Development of Severe Acute Pancreatitis

Author

Sakuma, Yojiro, primary, Kodama, Yuzo, additional, Matsumori, Tomoaki, additional, Tomono, Teruko, additional, Kakiuchi, Nobuyuki, additional, Mima, Atsushi, additional, Yamauchi, Yuki, additional, Nishikawa, Yoshihiro, additional, Tsuda, Motoyuki, additional, Ueda, Tatsuki, additional, Kuriyama, Katsutoshi, additional, Maruno, Takahisa, additional, Ota, Yuji, additional, Shiokawa, Masahiro, additional, Tsuji, Yoshihisa, additional, Uza, Norimitsu, additional, Watanabe, Tomohiro, additional, Nakase, Hiroshi, additional, Seno, Hiroshi, additional, and Chiba, Tsutomu, additional

Published
2016
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38. Tu1489 Role of Activation-Induced Cytidine Deaminase (Aid) in Pancreatic Cancer Development

Author

Ota, Yuji, primary, Kodama, Yuzo, additional, Sawai, Yugo, additional, Kakiuchi, Nobuyuki, additional, Tomono, Teruko, additional, Matsumori, Tomoaki, additional, Mima, Atsushi, additional, Yamauchi, Yuki, additional, Nishikawa, Yoshihiro, additional, Tsuda, Motoyuki, additional, Kuriyama, Katsutoshi, additional, Sakuma, Yojiro, additional, Ueda, Tatsuki, additional, Maruno, Takahisa, additional, Shiokawa, Masahiro, additional, Uza, Norimitsu, additional, Marusawa, Hiroyuki, additional, Seno, Hiroshi, additional, and Chiba, Tsutomu, additional

Published
2016
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39. Pathogenicity of IgG in patients with IgG4-related disease

Author

Shiokawa, Masahiro, primary, Kodama, Yuzo, additional, Kuriyama, Katsutoshi, additional, Yoshimura, Kenichi, additional, Tomono, Teruko, additional, Morita, Toshihiro, additional, Kakiuchi, Nobuyuki, additional, Matsumori, Tomoaki, additional, Mima, Atsushi, additional, Nishikawa, Yoshihiro, additional, Ueda, Tatsuki, additional, Tsuda, Motoyuki, additional, Yamauchi, Yuki, additional, Minami, Ryuki, additional, Sakuma, Yojiro, additional, Ota, Yuji, additional, Maruno, Takahisa, additional, Kurita, Akira, additional, Sawai, Yugo, additional, Tsuji, Yoshihisa, additional, Uza, Norimitsu, additional, Matsumura, Kazuyoshi, additional, Watanabe, Tomohiro, additional, Notohara, Kenji, additional, Tsuruyama, Tatsuaki, additional, Seno, Hiroshi, additional, and Chiba, Tsutomu, additional

Published
2016
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44. [A Case of Rectal Cancer with Portal Vein Tumor Thrombosis Successfully Treated with First-Line Panitumumab Monotherapy].

Author

Takahara B, Mima A, Sasaki K, and Mima K

Subjects
Aged, Combined Modality Therapy, Humans, Male, Neoplasm Staging, Panitumumab, Proto-Oncogene Proteins genetics, Proto-Oncogene Proteins p21(ras), Rectal Neoplasms complications, Rectal Neoplasms genetics, Rectal Neoplasms pathology, ras Proteins genetics, Antibodies, Monoclonal therapeutic use, Antineoplastic Agents therapeutic use, Portal Vein pathology, Rectal Neoplasms drug therapy, Thrombosis etiology
Abstract

The patient was a 66-year-old man with progressive rectal cancer and portal vein tumor thrombosis near the porta hepatis. A subileus further complicated the situation. Therefore, an abdominoperineal resection was performed. As the KRAS gene was the wild-type gene, we administered panitumumab monotherapy every 2 weeks after the operation. Two months after the operation, the tumor marker levels were normal and the tumor size was reduced. Hence, oral capecitabine, with 1-week administration followed by 1-week of rest, was added to the therapy. In the 12 months after the operation, panitumumab was stopped once, and treatment with capecitabine alone was continued in the same schedule. As of 26 months, the disease showed a partial response using capecitabine alone. We report our experience of a case of rectal cancer with portal vein tumor thrombosis that was successfully treated with panitumumab.

Published
2015

45. [CT enterography with polyethylene glycol electrolyte solution for diagnosis of Crohn's disease].

Author

Ohana M, Mima A, Sonoyama H, Kikuchi S, Okabe M, Morisawa T, Shio S, Miyajima S, Kida H, Okano A, Okinaga S, Kusumi F, and Nabeshima M

Subjects
Adolescent, Adult, Aged, Electrolytes, Female, Humans, Intestine, Small diagnostic imaging, Male, Middle Aged, Tomography, X-Ray Computed, Contrast Media, Crohn Disease diagnostic imaging, Polyethylene Glycols
Abstract

This study aimed to assess the diagnostic usefulness of CT enterography (CTE) in Crohn's disease in Japanese patients. A total of 32 cases with bowel symptoms underwent CT enterography with polyethylene glycol electrolyte solution as oral contrast medium, among which 18 were clinically diagnosed as Crohn's disease and 14 were not: ulcerative colitis 1, Beçhet disease 1, simple ulcer 1, inflammatory bowel disease without definite diagnosis 5 and bowel symptoms of unknown origin 6. The incidence of bowel wall thickening, mural hyperenhancement, "the comb sign", mesenteric lymph nodes swelling, and stenosis were significantly higher in Crohn's disease than in other disease. Moreover, uneven bowel wall thickening and unilateral mural hyperenhancement on CTE were characteristic features of Crohn's disease, which our original quantitative evaluation with imaging analysis could support. Consequently, CTE is useful in Japanese patients with Crohn's disease.

Published
2012

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