Search

Your search keyword '"Millot, Jean-Louis"' showing total 137 results
Start Over Author "Millot, Jean-Louis"
137 results on '"Millot, Jean-Louis"'

2. The Fate of Transplanted Olfactory Progenitors Is Conditioned by the Cell Phenotypes of the Receiver Brain Tissue in Cocultures

Author

Pourié Grégory, Akchiche Nassila, Millot Jean-Louis, Guéant Jean-Louis, Daval Jean-Luc, and Bossenmeyer-Pourié Carine

Subjects
cellular therapy, olfactory progenitors, circuit integration, cortex, hippocampus, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Among the numerous candidates for cell therapy of the central nervous system (CNS), olfactory progenitors (OPs) represent an interesting alternative because they are free of ethical concerns, are easy to collect, and allow autologous transplantation. In the present study, we focused on the optimization of neuron production and maturation. It is known that plated OPs respond to various trophic factors, and we also showed that the use of Nerve Growth Factor (NGF) allowed switching from a 60/40 neuron/glia ratio to an 80/20 one. Nevertheless, in order to focus on the integration of OPs in mature neural circuits, we cocultured OPs in primary cultures obtained from the cortex and hippocampus of newborn mice. When dissociated OPs were plated, they differentiated into both glial and neuronal phenotypes, but we obtained a 1.5-fold higher viability in cortex/OP cocultures than in hippocampus/OP ones. The fate of OPs in cocultures was characterized with different markers such as BrdU, Map-2, and Synapsin, indicating a healthy integration. These results suggest that the integration of transplanted OPs might by affected by trophic factors and the environmental conditions/cell phenotypes of the host tissue. Thus, a model of coculture could provide useful information on key cell events for the use of progenitors in cell therapy.

Published
2020
Full Text
View/download PDF

9. Left: right differences in psychophysical and electrodermal measures of olfactory thresholds and their relation to electrodermal indices of hemispheric asymmetries

Author

Brand, Gerard, Millot, Jean-Louis, Jacquot, Laurence, Thomas, Stephanie, and Wetzel, Sonia

Subjects
Cognition -- Research, Health, Psychology and mental health
Abstract

The study of lateralization processes in olfaction in human subjects has given rise to many contradictory findings. Indeed, sensorial cerebral asymmetry in olfaction depends on several factors (nature of task, quality of stimulus, characteristics of subjects, etc.) and could be also related to differences between the nostrils. In this field, few studies have assessed simultaneously the left-right nostril differences and the hemispheric asymmetry. The present work dealt with this question in the same population with the same odorants, procedures, and stimulations. Seven different concentrations of four specific odorants (two pleasant and two unpleasant) were used by single nostril stimulation with 30 dextral subjects (20 women and 10 men). Threshold detection in unilateral stimulation was investigated using electrodermal response to confirm the first psychophysic measure. Moreover, bilateral recordings of electrodermal activity (EDA) with unilateral stimulation were used as a measure of functional hemispheric asymmetry. Analysis showed no differences between the two nostrils for the threshold detection regardless of the method used (psychophysic or EDA response). However, most subjects presented a constant direction of dectrodermal asymmetry whichever nostril was stimulated and whichever odorant stimulus used. The constant bilateral differences in EDA recordings are discussed in terms of asymmetrical activation of the hemispheres.

Published
2004

10. Sex differences in human olfaction: between evidence and enigma

Author

Brand, Gerard and Millot, Jean-Louis

Subjects
Sex differences (Psychology) -- Research, Smell -- Demographic aspects, Smell -- Testing, Sex differences -- Research, Health, Psychology and mental health, Science and technology
Abstract

The sex of individuals plays an important part in determining their olfactory abilities, with females generally being superior to males. The present review examines the way in which sex differences influence sensitivity, identification, familiarity, and recognition of odours. It also examines whether sex differences are more pronounced with some odours than others, and how sex differences are affected by the manner of testing. Two different explanations for the superiority of females over males in olfaction are evaluated.

Published
2001

11. Behavioral lateralization during spontaneous smelling tasks

Author

Millot, Jean-Louis and Brand, Gerard

Subjects
Smell -- Physiological aspects, Left- and right-handedness -- Research, Psychophysiology -- Research, Health, Psychology and mental health
Abstract

The smelling behavior of 52 right-handed subjects was videotaped during tasks involving identification and recognition of different odors. Analysis showed that men more often used the right nostril than the left whatever the odor. There was no significant difference for the women. These results support a more marked cerebral asymmetry in men than in women and a main involvement of the right cerebral hemisphere in the olfactory processes at least by right-handed men.

Published
2000

16. Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse

Author

Peterschmitt, Yvan, Abdoul-Azize, Souleymane, Murtaza, Babar, Barbier, Marie, Khan, Amira Sayed, Millot, Jean-Louis, Khan, Naim Akhtar, Laboratoire de Neurosciences Intégratives et Cliniques - UFC (EA 481) (NEURO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe NuTox (LNC - U1231) (NUTOX), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), and Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement

Subjects
Male, linoleic acid, lcsh:TX341-641, gustation, Article, Reward, Neural Pathways, Zif-268, Animals, Early Growth Response Protein 1, Glucose Transporter Type 1, c-Fos, Neuronal Plasticity, Behavior, Animal, Brain-Derived Neurotrophic Factor, Brain, Taste Perception, Taste Buds, fat taste, Mice, Inbred C57BL, BDNF, Taste, Glut-1, Proto-Oncogene Proteins c-fos, lcsh:Nutrition. Foods and food supply, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, hedonic
Abstract

International audience; The origin of spontaneous preference for dietary lipids in humans and rodents is debated, though recent compelling evidence has shown the existence of fat taste that might be considered a sixth taste quality. We investigated the implication of gustatory and reward brain circuits, triggered by linoleic acid (LA), a long-chain fatty acid. The LA was applied onto the circumvallate papillae for 30 min in conscious C57BL/6J mice, and neuronal activation was assessed using c-Fos immunohistochemistry. By using real-time reverse transcription polymerase chain reaction (RT-qPCR), we also studied the expression of mRNA encoding brain-derived neurotrophic factor (BDNF), Zif-268, and Glut-1 in some brain areas of these animals. LA induced a significant increase in c-Fos expression in the nucleus of solitary tract (NST), parabrachial nucleus (PBN), and ventroposterior medialis parvocellularis (VPMPC) of the thalamus, which are the regions known to be activated by gustatory signals. LA also triggered c-Fos expression in the central amygdala and ventral tegmental area (VTA), involved in food reward, in conjunction with emotional traits. Interestingly, we noticed a high expression of BDNF, Zif-268, and Glut-1 mRNA in the arcuate nucleus (Arc) and hippocampus (Hipp), where neuronal activation leads to memory formation. Our study demonstrates that oral lipid taste perception might trigger the activation of canonical gustatory and reward pathways.

Published
2018
Full Text
View/download PDF

17. Assessment of Olfactory Perception in Individuals with Motion Sickness

Author

Jacquot, Laurence, Millot, Jean-Louis, Paillard, Aurora, Jacquot, Laurence, Millot, Jean-Louis, and Paillard, Aurora

Abstract

BACKGROUND: Individuals who experience motion sickness (MS) frequently mention the presence of smells in the environment as a factor favoring the occurrence of MS symptoms. The aim of the present work was to compare olfactory function in MS sensitive (MS+) and insensitive (MS-) subjects. METHODS: Olfactory testing included determination of odor detection thresholds, subjective evaluation of the quality (intensity, hedonicity, and familiarity) of three different odorants (limonene, isovaleric acid, and petrol) as well as measures of skin conductance responses to these three odorants. RESULTS: Results showed no difference in olfactory sensitivity between MS+ and MS- subjects. However, findings of both subjective (odor quality self-rating) and objective (psychophysiological responses) measures did reveal that the affective response to petrol odor was significantly different in MS+ and in MS- subjects. Indeed, on a scale from 0 (unpleasant) to 10 (pleasant) MS+ subjects rated petrol odor as more unpleasant (mean = 2.52) than MS- subjects (mean = 4.15) and rise-time of skin conductance responses to petrol odor was significantly longer in MS+ (mean = 5.98 s) compared to MS- subjects (mean = 3.22 s). DISCUSSION: Our study delves further into the knowledge of the relationship between motion sickness and olfaction by demonstrating a modified olfactory perception in motion sickness sensitive subjects at both the psychophysical and psychophysiological levels.

Published
2018

25. Rôle du langage intérieur dans la flexibilité mentale – Étude électromyographique

Author

Laurent, Lucie, Millot, Jean-Louis, Andrieu, Patrice, Camos, Valérie, Floccia, Caroline, Mathy, Fabien, Bases, Corpus, Langage, UMR 7320, Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) (NEURO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Nanomédecine, imagerie, thérapeutique - UFC (UR 4662) (NIT / NANOMEDECINE), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] (LEAD), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB), Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Neurosciences Intégratives et Cliniques - UFC ( NEURO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Nanomédecine, imagerie, thérapeutique - UFC ( NIT / NANOMEDECINE ), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] ( LEAD ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Franche-Comté ( UFC ), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (EA 481) (NEURO), and Nanomédecine, imagerie, thérapeutique - UFC (EA 4662) (NIT / NANOMEDECINE)

Subjects
[ SHS.LANGUE ] Humanities and Social Sciences/Linguistics, [ SCCO.LING ] Cognitive science/Linguistics, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, [SCCO.LING]Cognitive science/Linguistics, [SCCO.LING] Cognitive science/Linguistics, [SHS.LANGUE] Humanities and Social Sciences/Linguistics, linguistique
Abstract

no abstract

Published
2013

26. Quel est le rôle du langage intérieur dans les fonctions exécutives ? Une approche électromyographique laryngée de l'alternance de tâches

Author

Mathy, Fabien, Millot, Jean-Louis, Université de Franche-Comté ( UFC ), Laboratoire de Neurosciences Intégratives et Cliniques - UFC ( NEURO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) (NEURO), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and Laboratoire de Neurosciences Intégratives et Cliniques - UFC (EA 481) (NEURO)

Subjects
[ SHS.LANGUE ] Humanities and Social Sciences/Linguistics, [ SCCO.LING ] Cognitive science/Linguistics, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, [SCCO.LING]Cognitive science/Linguistics
Abstract

no abstract

Published
2013

27. Production de langage intériorisé dans l'exécution d'activités complexes alternées en fonction de l'âge

Author

Laurent, Lucie, Millot, Jean-Louis, Andrieu, Patrice, Camos, Valérie, Floccia, Caroline, Mathy, Fabien, Laboratoire de Neurosciences Intégratives et Cliniques - UFC ( NEURO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Nanomédecine, imagerie, thérapeutique - UFC ( NIT / NANOMEDECINE ), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] ( LEAD ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Franche-Comté ( UFC ), Bases, Corpus, Langage, UMR 7320, Laboratoire de Neurosciences Intégratives et Cliniques - UFC (EA 481) (NEURO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Nanomédecine, imagerie, thérapeutique - UFC (EA 4662) (NIT / NANOMEDECINE), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] (LEAD), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB), Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) (NEURO), and Nanomédecine, imagerie, thérapeutique - UFC (UR 4662) (NIT / NANOMEDECINE)

Subjects
[ SHS.LANGUE ] Humanities and Social Sciences/Linguistics, [ SCCO.LING ] Cognitive science/Linguistics, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, [SCCO.LING]Cognitive science/Linguistics, [SCCO.LING] Cognitive science/Linguistics, [SHS.LANGUE] Humanities and Social Sciences/Linguistics, linguistique
Abstract

no abstract

Published
2012

28. Inner speech and task switching in adults

Author

Laurent, Lucie, Millot, Jean-Louis, Andrieu, Patrice, Camos, Valérie, Floccia, Caroline, Mathy, Fabien, Laboratoire de Neurosciences Intégratives et Cliniques - UFC ( NEURO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Nanomédecine, imagerie, thérapeutique - UFC ( NIT / NANOMEDECINE ), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] ( LEAD ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Franche-Comté ( UFC ), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) (NEURO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Nanomédecine, imagerie, thérapeutique - UFC (UR 4662) (NIT / NANOMEDECINE), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] (LEAD), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB), Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (EA 481) (NEURO), Nanomédecine, imagerie, thérapeutique - UFC (EA 4662) (NIT / NANOMEDECINE), and Bases, Corpus, Langage, UMR 7320

Subjects
[ SHS.LANGUE ] Humanities and Social Sciences/Linguistics, [ SCCO.LING ] Cognitive science/Linguistics, [SCCO.LING] Cognitive science/Linguistics, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, [SCCO.LING]Cognitive science/Linguistics, [SHS.LANGUE] Humanities and Social Sciences/Linguistics, linguistique
Abstract

no abstract

Published
2012

30. Is there a relationship between odors and motion sickness?

Author

Quarck, Gaëlle, Etard, Olivier, Lamôré, Maryam, Millot, Jean-Louis, Jacquot, Laurence, Denise, Pierre, Paillard, Aurora, Quarck, Gaëlle, Etard, Olivier, Lamôré, Maryam, Millot, Jean-Louis, Jacquot, Laurence, Denise, Pierre, and Paillard, Aurora

Abstract

Poster

Published
2014

34. Olfactory perception and motion sickness

Author

Paillard, Aurora, Jacquot, Laurence, Millot, Jean-Louis, Paillard, Aurora, Jacquot, Laurence, and Millot, Jean-Louis

Abstract

The motion complexity of modern vehicles may cause several symptoms as nausea, headache, postural discomfort and unsteadiness that are classified within the broad definition of motion sickness (Golding, 2005). Whereas the scientific community renews efforts to develop some behavioural and pharmaceutical techniques to sup- press motion sickness, this problem is not resolved yet. Interestingly, several authors proposed that unpleasant odors could contribute to motion sickness (Glaser, 1959; Turner and Griffin, 1999; Fessler and Arguello, 2004). However, the relation between olfactory system and motion sickness has not been previously investigated. For this purpose, subjects were recruited among healthy and non-smoker women fulfilling Golding’s (1998) Motion Sickness Susceptibility Questionnaire (MSSQ). Subjects were divided in two groups: (1) subjects who are very sensitive to motion sickness (N=10), (2) subjects who are not sensitive to motion sickness (N=10). We compared with usual psychophysics methods the olfactory sensitivity (i.e. threshold testing with the odor of n-butanol), and the self-ratings of intensity, familiarity and hedonic valence of a panel of seventeen odorants. Our results showed: (i) a poor olfactory sensitivity in subjects sensitive to motion sickness (Intergroup T-test, T=2.63), (ii) that motion sickness sensitive subjects judged the odor of leather as more unpleasant than the other group (Inter- group T-test, T=-3.53), (iii) motion sickness sensitive subjects judged the odor of petrol as more unpleasant (Intergroup T-test, T=-3.46) and more familiar than the other group (Intergroup T- test, T=2.43). The present results pointed out some differences on olfactory perception relative to motion sickness susceptibility. Herz (2005) high- lighted that the emotional context in which an odor is encountered could influence odor hedonic perception and odor-related behaviour. Thus, we could proposed that subjects who are very sensitive to motion

Published
2010

45. Book Reviews

Author

Taylor, Nicola, primary, Lobban, Richard A., additional, Millot, Jean-Louis, additional, Beck, Alan M., additional, and Rowan, Andrew N., additional

Published
2000
Full Text
View/download PDF

50. L'Homme et l'Animal: un Débat de Société.

Author

Millot, Jean-Louis

Subjects
HUMAN-animal relationships, NONFICTION
Abstract

The article reviews the book "L'Homme et l'Animal: un Débat de Société (Humans and Animals: a Social Debate)," edited by Arouna P. Ouédrago and Pierre Le Neindre.

Published
2000

Catalog

Books, media, physical & digital resources
See catalog results