303 results on '"Millman, R"'
Search Results
2. Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol
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Sydes, M.R., Spears, M.R., Mason, M.D., Clarke, N.W., Dearnaley, D.P., de Bono, J.S., Attard, G., Chowdhury, S., Cross, W., Gillessen, S., Malik, Z.I., Jones, R., Parker, C.C., Ritchie, A.W.S., Russell, J.M., Millman, R., Matheson, D., Amos, C., Gilson, C., Birtle, A., Brock, S., Capaldi, L., Chakraborti, P., Choudhury, A., Evans, L., Ford, D., Gale, J., Gibbs, S., Gilbert, D.C., Hughes, R., McLaren, D., Lester, J.F., Nikapota, A., O’Sullivan, J., Parikh, O., Peedell, C., Protheroe, A., Rudman, S.M., Shaffer, R., Sheehan, D., Simms, M., Srihari, N., Strebel, R., Sundar, S., Tolan, S., Tsang, D., Varughese, M., Wagstaff, J., Parmar, M.K.B., and James, N.D.
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- 2018
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3. Binaural summation of amplitude modulation involves weak interaural suppression
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Baker, D. H., Vilidaite, G., McClarnon, E., Valkova, E., Bruno, A., and Millman, R. E.
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- 2020
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4. Registered Replication Report: Study 1 From Finkel, Rusbult, Kumashiro, & Hannon (2002)
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Cheung, Irene, Campbell, Lorne, LeBel, Etienne P., Ackerman, R. A., Aykutoğlu, B., Bahník, Š., Bowen, J. D., Bredow, C. A., Bromberg, C., Caprariello, P. A., Carcedo, R. J., Carson, K. J., Cobb, R. J., Collins, N. L., Corretti, C. A., DiDonato, T. E., Ellithorpe, C., Fernández-Rouco, N., Fuglestad, P. T., Goldberg, R. M., Golom, F. D., Gündoğdu-Aktürk, E., Hoplock, L. B., Houdek, P., Kane, H. S., Kim, J. S., Kraus, S., Leone, C. T., Li, N. P., Logan, J. M., Millman, R. D., Morry, M. M., Pink, J. C., Ritchey, T., Luna, L. M. Root, Sinclair, H. C., Stinson, D. A., Sucharyna, T. A., Tidwell, N. D., Uysal, A., Vranka, M., Winczewski, L. A., and Yong, J. C.
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- 2016
5. LBA62 Comparison of abiraterone acetate and prednisolone (AAP) or combination enzalutamide (ENZ) + AAP for metastatic hormone sensitive prostate cancer (mHSPC) starting androgen deprivation therapy (ADT): Overall survival (OS) results of 2 randomised phase III trials from the STAMPEDE protocol
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Attard, G., primary, Murphy, L., additional, Clarke, N., additional, Cross, W., additional, Gillessen, S., additional, Amos, C., additional, Brawley, C., additional, Jones, R., additional, Pezaro, C., additional, Malik, Z., additional, Montazeri, A., additional, Millman, R., additional, Cook, A., additional, Gilbert, D., additional, Langley, R., additional, Parker, C., additional, Sydes, M., additional, Brown, L., additional, Parmar, M., additional, and James, N., additional
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- 2022
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6. Concluding Remarks
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Clarke, B., Grevholm, B., Millman, R., Peter-Koop, Andrea, editor, Wilson, Patricia, editor, Clarke, Barbara, editor, Grevholm, Barbro, editor, and Millman, Richard, editor
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- 2009
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7. Management of Patients with Advanced Prostate Cancer: Report from the Advanced Prostate Cancer Consensus Conference 2021
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Gillessen, S. Armstrong, A. Attard, G. Beer, T.M. Beltran, H. Bjartell, A. Bossi, A. Briganti, A. Bristow, R.G. Bulbul, M. Caffo, O. Chi, K.N. Clarke, C.S. Clarke, N. Davis, I.D. de Bono, J.S. Duran, I. Eeles, R. Efstathiou, E. Efstathiou, J. Ekeke, O.N. Evans, C.P. Fanti, S. Feng, F.Y. Fizazi, K. Frydenberg, M. George, D. Gleave, M. Halabi, S. Heinrich, D. Higano, C. Hofman, M.S. Hussain, M. James, N. Jones, R. Kanesvaran, R. Khauli, R.B. Klotz, L. Leibowitz, R. Logothetis, C. Maluf, F. Millman, R. Morgans, A.K. Morris, M.J. Mottet, N. Mrabti, H. Murphy, D.G. Murthy, V. Oh, W.K. Ost, P. O'Sullivan, J.M. Padhani, A.R. Parker, C. Poon, D.M.C. Pritchard, C.C. Rabah, D.M. Rathkopf, D. Reiter, R.E. Rubin, M. Ryan, C.J. Saad, F. Sade, J.P. Sartor, O. Scher, H.I. Shore, N. Skoneczna, I. Small, E. Smith, M. Soule, H. Spratt, D.E. Sternberg, C.N. Suzuki, H. Sweeney, C. Sydes, M.R. Taplin, M.-E. Tilki, D. Tombal, B. Türkeri, L. Uemura, H. Uemura, H. van Oort, I. Yamoah, K. Ye, D. Zapatero, A. Omlin, A.
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education - Abstract
Background: Innovations in treatments, imaging, and molecular characterisation in advanced prostate cancer have improved outcomes, but various areas of management still lack high-level evidence to inform clinical practice. The 2021 Advanced Prostate Cancer Consensus Conference (APCCC) addressed some of these questions to supplement guidelines that are based on level 1 evidence. Objective: To present the voting results from APCCC 2021. Design, setting, and participants: The experts identified three major areas of controversy related to management of advanced prostate cancer: newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC), the use of prostate-specific membrane antigen ligands in diagnostics and therapy, and molecular characterisation of tissue and blood. A panel of 86 international prostate cancer experts developed the programme and the consensus questions. Outcome measurements and statistical analysis: The panel voted publicly but anonymously on 107 pre-defined questions, which were developed by both voting and non-voting panel members prior to the conference following a modified Delphi process. Results and limitations: The voting reflected the opinions of panellists and did not incorporate a standard literature review or formal meta-analysis. The answer options for the consensus questions received varying degrees of support from panellists, as reflected in this article and the detailed voting results reported in the Supplementary material. Conclusions: These voting results from a panel of experts in advanced prostate cancer can help clinicians and patients to navigate controversial areas of management for which high-level evidence is scant. However, diagnostic and treatment decisions should always be individualised according to patient characteristics, such as the extent and location of disease, prior treatment(s), comorbidities, patient preferences, and treatment recommendations, and should also incorporate current and emerging clinical evidence and logistic and economic constraints. Enrolment in clinical trials should be strongly encouraged. Importantly, APCCC 2021 once again identified salient questions that merit evaluation in specifically designed trials. Patient summary: The Advanced Prostate Cancer Consensus Conference is a forum for discussing current diagnosis and treatment options for patients with advanced prostate cancer. An expert panel votes on predefined questions focused on the most clinically relevant areas for treatment of advanced prostate cancer for which there are gaps in knowledge. The voting results provide a practical guide to help clinicians in discussing treatment options with patients as part of shared decision-making. © 2022 The Author(s)
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- 2022
8. Corrigendum to 'What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021' [Eur Urol 82(1):6–11] (European Urology (2022) 82(1) (6–11), (S0302283822016505), (10.1016/j.eururo.2022.02.010))
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Turco, F. Armstrong, A. Attard, G. Beer, T.M. Beltran, H. Bjartell, A. Bossi, A. Briganti, A. Bristow, R.G. Bulbul, M. Caffo, O. Chi, K.N. Clarke, C. Clarke, N. Davis, I.D. de Bono, J. Duran, I. Eeles, R. Efstathiou, E. Efstathiou, J. Evans, C.P. Fanti, S. Feng, F.Y. Fizazi, K. Frydenberg, M. George, D. Gleave, M. Halabi, S. Heinrich, D. Higano, C. Hofman, M.S. Hussain, M. James, N. Jones, R. Kanesvaran, R. Khauli, R.B. Klotz, L. Leibowitz, R. Logothetis, C. Maluf, F. Millman, R. Morgans, A.K. Morris, M.J. Mottet, N. Mrabti, H. Murphy, D.G. Murthy, V. Oh, W.K. Ekeke, O.N. Ost, P. O'Sullivan, J.M. Padhani, A.R. Parker, C. Poon, D.M.C. Pritchard, C.C. Rabah, D.M. Rathkopf, D. Reiter, R.E. Rubin, M. Ryan, C.J. Saad, F. Sade, J.P. Sartor, O. Scher, H.I. Shore, N. Skoneczna, I. Small, E. Smith, M. Soule, H. Spratt, D. Sternberg, C.N. Suzuki, H. Sweeney, C. Sydes, M. Taplin, M.-E. Tilki, D. Tombal, B. Türkeri, L. Uemura, H. Uemura, H. van Oort, I. Yamoah, K. Ye, D. Zapatero, A. Gillessen, S. Omlin, A.
- Abstract
The authors regret that Axel Heidenreich was added to the author list in error. The author list is now corrected as above, however the affiliations of remaining authors have been retained. The authors would like to apologise for any inconvenience caused. © 2022 The Author(s)
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- 2022
9. Associations of sleep disturbance and duration with metabolic risk factors in obese persons with type 2 diabetes: data from the Sleep AHEAD Study
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St-Onge MP, Zammit G, Reboussin DM, Kuna ST, Sanders MH, Millman R, Newman AB, Wadden TA, Wing RR, Pi-Sunyer FX, and Foster GD
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Psychiatry ,RC435-571 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Marie-Pierre St-Onge,1 Gary Zammit,2 David M Reboussin,3 Samuel T Kuna,4 Mark H Sanders,8 Richard Millman,6 Anne B Newman,5 Thomas A Wadden,4 Rena R Wing,6 F Xavier Pi-Sunyer,1 Gary D Foster7 Sleep AHEAD Research Group*1New York Obesity Research Center, St Luke's/Roosevelt Hospital, New York, NY, USA; 2Clinilabs, New York, NY, USA; 3Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA; 4Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA; 5Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA; 6Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA; 7Center for Obesity Research and Education, Temple University, Philadelphia, PA, USA; 8Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, PA, USA*A full list of the members of the Sleep AHEAD Research Group is available in an online appendixPurpose: Some studies have found an association between sleep disturbances and metabolic risk, but none has examined this association in individuals with type 2 diabetes. The objective of this study was to determine the relationship between sleep disturbances and metabolic risk factors in obese patients with type 2 diabetes.Patients and methods: This study was a cross-sectional examination of the relationship between sleep parameters (apnea/hypopnea index [AHI], time spent in various sleep stages) and metabolic risk markers (fasting glucose, hemoglobin A1c, lipids) using baseline data of the Sleep AHEAD cohort. Subjects (n = 305) were participants in Sleep AHEAD (Action for Health in Diabetes), a four-center ancillary study of the Look AHEAD study, a 16-center clinical trial of overweight and obese participants with type 2 diabetes, designed to assess the long-term effects of an intensive lifestyle intervention on cardiovascular events. All participants underwent one night of in-home polysomnography and provided a fasting blood sample. Regression analyses estimated the relationship between sleep variables and metabolic risk factors. Models were adjusted for study center, age, sex, race/ethnicity, waist circumference, smoking, alcohol intake, diabetes duration, and relevant medications.Results: Of 60 associations tested, only one was significant: fasting glucose was associated with sleep efficiency (estimate −0.53 ± [standard error] 0.26, P = 0.041). No associations were found between any of the sleep variables and lipid profile or hemoglobin A1c.Conclusions: The present data show only weak associations between select sleep variables and metabolic risk factors and do not provide strong support for a role of sleep on metabolic abnormalities in obese patients with type 2 diabetes.Keywords: obesity, obstructive sleep apnea, metabolic risk, sleep, diabetes
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- 2012
10. 801 EFFECTIVENESS OF HEARING REHABILITATION FOR CARE HOME RESIDENTS WITH DEMENTIA: A SYSTEMATIC REVIEW
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Cross, H, primary, Dawes, P, additional, Hooper, E, additional, Armitage, C J, additional, Leroi, I, additional, and Millman, R E, additional
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- 2022
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11. The Geometry of Connections
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Millman, R. S. and Stehney, Ann K.
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- 1973
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12. Some Unsettled Questions in Organization Theory
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Millman, R. William
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- 1964
13. Numerical Stability of a One-Evaluation Predictor-Corrector Algorithm for Numerical Solution of Ordinary Differential Equations
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Klopfenstein, R. W. and Millman, R. S.
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- 1968
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14. Measurement Reliability for Acupoint Activity Determined with the Prognos Ohmmeter
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Turner, L., Linden, W., Talbot Ellis, A., and Millman, R.
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- 2010
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15. Poster abstracts
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Ferrie, J., Shipley, M., Cappuccio, F., Brunner, E., Miller, M., Kumari, M., Marmot, M., Coenen, A., Castillo, J. L., Araya, F., Bustamante, G., Montecino, L., Torres, C., Oporto, S., Gronli, J., Fiske, E., Murison, R., Bjorvatn, B., Sorensen, E., Ursin, R., Portas, C. M., Rajaraman, S., Gribok, A., Wesensten, N., Balkin, T., Reifman, J., Dursunoglu, N., Ozkurt, S., Baser, S., Delen, O., Sarikaya, S., Sadler, P., Mitchell, P., Françon, D., Decobert, M., Herve, B., Richard, A., Griebel, G., Avenet, P., Scatton, B., Fur, G. L., Eckert, D., Jordan, A., Wellman, A., Smith, S., Malhotra, A., White, D., Bruck, D., Thomas, I., Kritikos, A., Oertel, W., Stiasny-Kolster, K., Garcia-Borreguero, D., Poewe, W., Hoegl, B., Kohnen, R., Schollmayer, E., Keffel, J., Trenkwalder, C., Valle, A., Roizenblatt, S., Fregni, F., Boggio, P., Tufik, S., Ward, K., Robertson, L., Palmer, L., Eastwood, P., Hillman, D., Lee, J., Mukherjee, S., de Padova, V., Barbato, G., Ficca, G., Zilli, I., Salzarulo, P., Veldi, M., Hion, T., Vasar, V., Kull, M., Nowak, L., Davis, J., Latzer, Y., Tzischinsky, O., Crowley, S., Carskadon, M., Anca-Herschkovitsch, M., Frey, D., Ortega, J., Wiseman, C., Farley, C., Wright, K., Campbell, A., Neill, A., Spiegel, K., Leproult, R., Tasali, E., Scherberg, N., van Cauter, E., Noradina, A. T., Karim, N. A., Norlinah, I., Raymond, A. A., Sahathevan, R., Hamidon, B., Werth, E., Poryazova, R., Khatami, R., Bassetti, C., Beran, R. G., Ainley, L., Holand, G., Duncan, J., Kinney, H., Davis, B., Hood, B., Frey, S., Schmidt, C., Hofstetter, M., Peigneux, P., Cajochen, C., Hu, W.-P., Li, J.-D., Zhang, C., Boehmer, L., Siegel, J., Zhou, Q.-Y., Sagawa, Y., Kondo, H., Takemura, T., Kanayama, H., Kaneko, Y., Sato, M., Kanbayashi, T., Hishikawa, Y., Shimizu, T., Viola, A., James, L., Schlangen, L., Dijk, D.-J., Andretic, R., Kim, Y.-C., Han, K.-A., Jones, F., Greenspan, R., Sanford, L., Yang, L., Tang, X., Dieter, K., Uta, E., Sven, H., Richard, M., Oyane, N., Pallesen, S., Holsten, F., Inoue, Y., Fujita, M., Emura, N., Kuroda, K., Uchimura, N., Johnston, A., Astbury, J., Kennedy, G., Hoedlmoser, K., Schabus, M., Pecherstorfer, T., Moser, S., Gruber, G., Anderer, P., Klimesch, W., Naidoo, N., Ferber, M., Pack, A., Neu, D., Mairesse, O., Hoffmann, G., Dris, A., Lambrecht, L., Linkowski, P., Verbanck, P., Le Bon, O., Matsuura, N., Yamao, M., Adachi, N., Aritomi, R., Komada, Y., Tanaka, H., Shirakawa, S., Kondoh, H., Takemura, F., Ohnuma, S., Suzuki, M., Uemura, S., Iskra-Golec, I., Smith, L., Thanh, D.-V., Boly, M., Phillips, C., Steven, L., Luxen, A., Maquet, M., Jay, S., Dawson, D., Lamond, N., Basner, M., Fomberstein, K., Dinges, D., Ogawa, K., Nittono, H., Yamazaki, K., Hori, T., Glamann, C., Hornung, O., Hansen, M.-L, Danker-Hopfe, H., Jung, C., Kecklund, G., Anund, A., Peters, B., Åkerstedt, T., Verster, J., Roehrs, T., Mets, M., de Senerpont Domis, L., Olivier, B., Volkerts, E., Knutson, K., Lauderdale, D., Rathouz, P., Christie, M., Chen, L., Bolortuya, Y., Lee, E., Mckenna, J., Mccarley, R., Strecker, R., Tamaki, M., Matsuoka, T., Aritake, S., Suzuki, H., Kuriyama, K., Ozaki, A., Abe, Y., Enomoto, M., Tagaya, H., Mishima, K., Matsuura, M., Uchiyama, M., Lima-Pacheco, E., Davis, K., Sabourin, C., Lortie-Lussier, M., de Koninck, J., van Der Werf, Y., van Der Helm, E., Schoonheim, M., van Someren, E., Tokley, M., Ball, M., Sato, T., Ghilardi, M. F., Moisello, C., Bove, M., Busi, M., Pelosin, E., Tononi, G., Eguchi, N., Sakata, M., Urade, Y., Doe, N., Yoshihara, K., Abe, K., Manabe, Y., Iwatsuki, K., Hayashi, T., Shoji, M., Kamiya, T., Gooley, J., Brainard, G., Rajaratnam, S., Kronauer, R., Czeisler, C., Lockley, S., Phillips, A., Robinson, P., Burgess, H., Revell, V., Eastman, C., Bihari, S., Ramakrishnan, N., Camerino, D., Conway, P. M., Costa, G., Vandewalle, G., Albouy, G., Sterpenich, V., Darsaud, A., Rauchs, G., Berken, P.-Y, Balteau, E., Maquet, P., Tendero, J. A., Domenech, M. P., Isern, F. S., Martínez, C., Roure, N., Sancho, E. E., Moreno, C. R., Silva, M., Marqueze, E. C., Waage, S., Bobko, N., Chernyuk, V., Yavorskiy, Y., Saxvig, I., Sørensen, E., de Mello, M. T., Esteves, A., Teixeira, C., Bittencourt, L. R., Silva, R., Pires, M. L., Mottram, V., Middelton, B., Arendt, J., Amaral, O., Rodrigues, M., Pereira, C., Tavares, I., Baba, K., Honma, S., Honma, K.-I., Yamanaka, Y., Hashimoto, S., Tanahashi, Y., Nishide, S.-Y, Honma, K.-I, Sletten, T., Middleton, B., Lederle, K., Skene, D., Roth, T., Walsh, J., Hogben, A., Ellis, J., Archer, S., von Schantz, M., Chen, N.-H., Wang, P.-C., Chen, C.-W., Lin, Y., Shih, T.-S., Armstrong, S., Redman, J., Stephan, E., David, M., Delanaud, S., Chardon, K., Libert, J.-P., Bach, V., Telliez, F., Reid, K., Jaksa, A., Eisengart, J., Kane, P., Naylor, E., Zee, P., Viola, A. U., de Valck, E., Hofmans, J., Theuns, P., Cluydts, R., Alexander, G., Karel, M., Christina, R., Sohn, I.-K., Cho, I. H., Kim, S. J., Yu, S.-H., Kim, H., Yoo, S. Y., Koh, S.-H., Cho, S.-J., Rotenberg, L., Silva-Costa, A., Griep, R. H., Amely, T., Kennedy, G. A., Pavlis, A., Thompson, B., Pierce, R., Howard, M., Briellmann, R., Venkateswaran, S., Blunden, S., Krawczyk, E., Blake, J., Gururajan, R., Kerr, D., Matuisi, T., Iwasaki, M., Yamasita, N., Iemura, A., Ohya, T., Yanagawa, T., Misa, R., Coleman, G., Conduit, R., Duce, B., Hukins, C., Nyandaiti, Y. W., Bamaki, S., Mohammed, A., Kwajarfa, S., Veeramachaneni, S. P., Murthy, A., Wilson, A., Maul, J., Hall, G., Stick, S., Moseley, L., Gradisar, M., Kurihara, T., Yamamoto, M., Yamamoto, S., Kuranari, M., Sparks, C. B., Bartle, A., Beckert, L., Latham-Smith, F. B., Hilton, J., Whitehead, B., Gulliver, T., Salvini, A., Grahame, S., Swift, M., Laybutt, N., Sharon, D., Mack, C., Hymell, B., Perrine, B., Ideshita, K., Taira, M., Matuo, A., Furutani, M., van Dongen, H., Mott, C., Huang, J.-K., Mollicone, D. J., Mckenzie, F., Dinges, David, Barnes, M., Rochford, P., Churchward, T., O’Donoghue, F., Penzel, T., Fietze, I., Canisius, S., Bekiaris, E., Terrill, P. I., Wilson, S., Suresh, S., Cooper, D., Suzuki, T., Ouchi, K., Moriya, A., Kameyama, K., Takahashi, M., Büttner, A., Rühle, K.-H., Wang, D., Wong, K., Dungan, II, G., Grunstein, R., Davidson, P., Jones, R., Gergely, V., Mashima, K., Miyazaki, S., Tanaka, T., Okawa, M., Yamada, N., Wyner, A., Raizen, D., Galante, R., Ng, A. K., Koh, T. S., Lim, L. L., Puvanendran, K., Peiris, M., Bones, P., Roebuck, T., Ho, S., Szollosi, I., Naughton, M., Williams, G., Parsley, C., Harris, M.-A., Thornton, A., Ruehland, W., Banks, S., Arroyo, S., Carroll, K., Pilmore, J., Stewart, C., Hamilton, G., van Acker, F., Cvetkovic, D., Holland, G., Cosic, I., Tolson, J., Worsnop, C., Cresswell, P., Hart, I., Bouarab, M., Delechelle, E., Drouot, X., Acebo, C., Singh, P., Lakey, T., Schachter, L., Rand, J., Collin, H., Snyder, E., Ma, J., Svetnick, V., Deacon, S., Dana, B., Konstanze, D., Uwe, M., Ingo, F., Thomas, P., Ivar, R., Mackiewicz, M., Shockley, K., Romer, M., Zimmerman, J., Baldwin, D., Jensen, S., Churchill, G., Paigen, B., Imeri, L., Ferrari, L., Bianchi, S., Dossena, S., Garofoli, A., Mangieri, M., Tagliavini, F., Forloni, G., Chiesa, R., Pedrazzoli, M., Pereira, D., Veauny, M., Bodenmann, S., Hohoff, C., Freitag, C., Deckert, J., Rétey, J., Landolt, H.-P., Strohl, K., Price, E., Yamauchi, M., Dostal, J., Feng, P., Han, F., Havekes, R., Novati, A., Hagewoud, R., Barf, P., van Der Borght, K., van Der Zee, E., Meerlo, P., Ruby, P., Caclin, A., Boulet, S., Delpuech, C., Morlet, D., Veasey, S., Aton, S., Jha, S., Coleman, T., Seibt, J., Frank, M., Lack, L., Churches, O., Feng, S. Y. S., Cassaglia, P., Yu, V. Y. H., Walker, A. M., Kohler, M., Kennedy, D., Martin, J., van Den Heuvel, C., Lushington, K., Herron, K., Khurana, C., Sterr, A., Olivadoti, M., Toth, L., Opp, M., Dang-Vu, T., Degueldre, C., Gais, S., Dang-Vu, T. T., Desseilles, M., Philips, C., Chijavadze, E., Babilodze, M., Chkhartishvili, E., Nachkebia, N., Mchedlidze, O., Dzadzamia, S., Griffiths, R., Walker, A., Horovitz, S., Fukunaga, M., Carr, W., Picchioni, D., de Zwart, J., van Gelderen, P., Braun, A., Duyn, J., Hanlon, E. H., Faraguna, U., Vyazovskiy, V., Cirelli, C., Ocampo-Garcés, A., Ibáñez, F., López, S., Vivaldi, E., Torrealba, F., Romanowski, C. P. N., Fenzl, T., Flachskamm, C., Deussing, J., Kimura, M., Tarokh, L., van Reen, E., Dorn, H., Velluti, R., Qu, W.-M., Huang, Z.-L., Hayaishi, O., Pedemonte, M., Drexler, D., Pol-Fernández, D., Bernhardt, V., Lopez, C., Rodriguez-Servetti, Z., Romanowski, C., Polta, S., Yassouridis, A., Abe, T., Takahashi, K., Koyama, Y., Kayama, Y., Lin, J.-S., Sakai, K., Gulia, K., Karashima, A., Shimazaki, M., Katayama, N., Nakao, M., Winsky-Sommerer, R., Knapman, A., Tobler, I., Altena, E., Sanz-Arigita, E., Chang, F.-C., Lu, C.-Y., Yi, P.-L., Hsiao, Y.-Z., Lowden, A., Nilsson, J., Hillert, L., Wiholm, C., Kuster, N., Arnetz, B., Szameitat, A., Shen, S., Daurat, A., Tiberge, M., Sok, N., D’Ortho, M. P. I. A., Karasinsky, P., Kohlmeier, K., Wess, J., Leonard, C., Kristensen, M., Kalinchuk, A., Porkka-Heiskanen, T., Mccarley, R. 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16. Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019[Formula presented]
- Author
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Gillessen, S. Attard, G. Beer, T.M. Beltran, H. Bjartell, A. Bossi, A. Briganti, A. Bristow, R.G. Chi, K.N. Clarke, N. Davis, I.D. de Bono, J. Drake, C.G. Duran, I. Eeles, R. Efstathiou, E. Evans, C.P. Fanti, S. Feng, F.Y. Fizazi, K. Frydenberg, M. Gleave, M. Halabi, S. Heidenreich, A. Heinrich, D. Higano, C.T.S. Hofman, M.S. Hussain, M. James, N. Kanesvaran, R. Kantoff, P. Khauli, R.B. Leibowitz, R. Logothetis, C. Maluf, F. Millman, R. Morgans, A.K. Morris, M.J. Mottet, N. Mrabti, H. Murphy, D.G. Murthy, V. Oh, W.K. Ost, P. O'Sullivan, J.M. Padhani, A.R. Parker, C. Poon, D.M.C. Pritchard, C.C. Reiter, R.E. Roach, M. Rubin, M. Ryan, C.J. Saad, F. Sade, J.P. Sartor, O. Scher, H.I. Shore, N. Small, E. Smith, M. Soule, H. Sternberg, C.N. Steuber, T. Suzuki, H. Sweeney, C. Sydes, M.R. Taplin, M.-E. Tombal, B. Türkeri, L. van Oort, I. Zapatero, A. Omlin, A.
- Abstract
At the Advanced Prostate Cancer Consensus Conference (APCCC) 2019, 10 important areas of controversy in advanced prostate cancer management were identified and discussed, and experts voted on 123 predefined consensus questions. The full report of the results is summarised here. © 2020 The Authors Background: Innovations in treatments, imaging, and molecular characterisation in advanced prostate cancer have improved outcomes, but there are still many aspects of management that lack high-level evidence to inform clinical practice. The Advanced Prostate Cancer Consensus Conference (APCCC) 2019 addressed some of these topics to supplement guidelines that are based on level 1 evidence. Objective: To present the results from the APCCC 2019. Design, setting, and participants: Similar to prior conferences, experts identified 10 important areas of controversy regarding the management of advanced prostate cancer: locally advanced disease, biochemical recurrence after local therapy, treating the primary tumour in the metastatic setting, metastatic hormone-sensitive/naïve prostate cancer, nonmetastatic castration-resistant prostate cancer, metastatic castration-resistant prostate cancer, bone health and bone metastases, molecular characterisation of tissue and blood, inter- and intrapatient heterogeneity, and adverse effects of hormonal therapy and their management. A panel of 72 international prostate cancer experts developed the programme and the consensus questions. Outcome measurements and statistical analysis: The panel voted publicly but anonymously on 123 predefined questions, which were developed by both voting and nonvoting panel members prior to the conference following a modified Delphi process. Results and limitations: Panellists voted based on their opinions rather than a standard literature review or formal meta-analysis. The answer options for the consensus questions had varying degrees of support by the panel, as reflected in this article and the detailed voting results reported in the Supplementary material. Conclusions: These voting results from a panel of prostate cancer experts can help clinicians and patients navigate controversial areas of advanced prostate management for which high-level evidence is sparse. However, diagnostic and treatment decisions should always be individualised based on patient-specific factors, such as disease extent and location, prior lines of therapy, comorbidities, and treatment preferences, together with current and emerging clinical evidence and logistic and economic constraints. Clinical trial enrolment for men with advanced prostate cancer should be strongly encouraged. Importantly, APCCC 2019 once again identified important questions that merit assessment in specifically designed trials. Patient summary: The Advanced Prostate Cancer Consensus Conference provides a forum to discuss and debate current diagnostic and treatment options for patients with advanced prostate cancer. The conference, which has been held three times since 2015, aims to share the knowledge of world experts in prostate cancer management with health care providers worldwide. At the end of the conference, an expert panel discusses and votes on predefined consensus questions that target the most clinically relevant areas of advanced prostate cancer treatment. The results of the voting provide a practical guide to help clinicians discuss therapeutic options with patients as part of shared and multidisciplinary decision making. © 2020 The Authors
- Published
- 2020
17. Individual differences in physiological responses to effortful listening
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Wang, X., Alhanbali, S., Millman, R., Munro, K., and Simpson, D.
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- 2023
- Full Text
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18. 611O Abiraterone acetate plus prednisolone for hormone-naïve prostate cancer (PCa): Long-term results from metastatic (M1) patients in the STAMPEDE randomised trial (NCT00268476)
- Author
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James, N., primary, Rush, H., additional, Clarke, N., additional, Attard, G., additional, Cook, A., additional, Dearnaley, D., additional, Gillessen, S., additional, Hoyle, A., additional, Jones, R., additional, Millman, R., additional, Birtle, A., additional, Chowdhury, S., additional, Gale, J., additional, Malik, Z., additional, O'Sullivan, J., additional, Pezaro, C., additional, Sheehan, D., additional, Tanguay, J., additional, Parmar, M.K., additional, and Sydes, M.R., additional
- Published
- 2020
- Full Text
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19. Corrigendum to Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial
- Author
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Clarke, N.W., primary, Ali, A., additional, Ingleby, F.C., additional, Hoyle, A., additional, Amos, C.L., additional, Attard, G., additional, Brawley, C.D., additional, Calvert, J., additional, Chowdhury, S., additional, Cook, A., additional, Cross, W., additional, Dearnaley, D.P., additional, Douis, H., additional, Gilbert, D., additional, Gillessen, S., additional, Jones, R.J., additional, Langley, R.E., additional, MacNair, A., additional, Malik, Z., additional, Mason, M.D., additional, Matheson, D., additional, Millman, R., additional, Parker, C.C., additional, Ritchie, A.W.S., additional, Rush, H., additional, Russell, J.M., additional, Brown, J., additional, Beesley, S., additional, Birtle, A., additional, Capaldi, L., additional, Gale, J., additional, Gibbs, S., additional, Lydon, A., additional, Nikapota, A., additional, Omlin, A., additional, O’Sullivan, J.M., additional, Parikh, O., additional, Protheroe, A., additional, Rudman, S., additional, Srihari, N.N., additional, Simms, M., additional, Tanguay, J.S., additional, Tolan, S., additional, Wagstaff, J., additional, Wallace, J., additional, Wylie, J., additional, Zarkar, A., additional, Sydes, M.R., additional, Parmar, M.K.B., additional, and James, N.D., additional
- Published
- 2020
- Full Text
- View/download PDF
20. Docetaxel for hormone-naïve prostate cancer: Results from long-term follow-up of metastatic (M1) patients in the STAMPEDE randomised trial (NCT00268476) and sub-group analysis by metastatic burden
- Author
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Clarke, N.W., primary, Ali, A., additional, Ingleby, F.C., additional, Hoyle, A., additional, Calvert, J., additional, Attard, G., additional, Chowdhury, S., additional, Dearnaley, D., additional, Douis, H., additional, Gillessen, S., additional, Jones, R., additional, Malik, Z., additional, Mason, M.D., additional, Millman, R., additional, Parker, C., additional, Rush, H.L., additional, Omlin, A.G., additional, Sydes, M.R., additional, Parmar, M.K.B., additional, and James, N.D., additional
- Published
- 2019
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21. DataViewer3D: An open-source, cross-platform multi-modal neuroimaging data visualization tool
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Gouws, A D, Woods, W, Millman, R E, Morland, A B, and Green, G
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- 2009
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22. Are oral appliances a substitute for nasal positive airway pressure?
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Millman, R P and Rosenberg, C L
- Published
- 2002
23. Radiotherapy (RT) to the primary tumour for men with newly-diagnosed metastatic prostate cancer (PCa): Survival results from STAMPEDE
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Parker, C.C., primary, James, N.D., additional, Brawley, C., additional, Clarke, N.W., additional, Attard, G., additional, Chowdhury, S., additional, Cross, W., additional, Dearnaley, D.P., additional, Gilson, C.E., additional, Jones, R., additional, Mason, M.D., additional, Millman, R., additional, Gillessen, S., additional, Eswar, C., additional, Gale, J., additional, Lester, J., additional, Sheehan, D., additional, Tran, A., additional, Parmar, M.K., additional, and Sydes, M.R., additional
- Published
- 2018
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24. Effects of menopause and nasal occlusion on breathing during sleep.
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Carskadon, M A, Bearpark, H M, Sharkey, K M, Millman, R P, Rosenberg, C, Cavallo, A, Carlisle, C, and Acebo, C
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- 1997
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25. Efficacy of a Herbst mandibular advancement device in obstructive sleep apnea.
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Eveloff, S E, Rosenberg, C L, Carlisle, C C, and Millman, R P
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- 1994
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26. The role of inflammation in the association between gestational diabetes and obstructive sleep apnea: A pilot study
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Bublitz, MH, primary, Carpenter, M, additional, Amin, S, additional, Okun, ML, additional, Millman, R, additional, De La Monte, SM, additional, and Bourjeily, G, additional
- Published
- 2018
- Full Text
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27. 020 Sexual Distress and Vaginal Symptom Severity in Women Diagnosed with Cancer: Impact of a Vaginal Health Workshop
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Millman, R., primary, Sears, C., additional, Jacox, N., additional, Booker, R., additional, Beck, A., additional, Santos-Iglesias, P., additional, Robinson, J., additional, and Walker, L., additional
- Published
- 2018
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28. 0808 A Prospective Study of Self-Reported Sleep After a Delay in School Start Times
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Sharkey, K M, primary, Millman, R P, additional, and Carskadon, M A, additional
- Published
- 2018
- Full Text
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29. 844O - Docetaxel for hormone-naïve prostate cancer: Results from long-term follow-up of metastatic (M1) patients in the STAMPEDE randomised trial (NCT00268476) and sub-group analysis by metastatic burden
- Author
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Clarke, N.W., Ali, A., Ingleby, F.C., Hoyle, A., Calvert, J., Attard, G., Chowdhury, S., Dearnaley, D., Douis, H., Gillessen, S., Jones, R., Malik, Z., Mason, M.D., Millman, R., Parker, C., Rush, H.L., Omlin, A.G., Sydes, M.R., Parmar, M.K.B., and James, N.D.
- Published
- 2019
- Full Text
- View/download PDF
30. Adding abiraterone acetate plus prednisolone (AAP) or docetaxel for patients (pts) with high-risk prostate cancer (PCa) starting long-term androgen deprivation therapy (ADT): Directly randomised data from STAMPEDE (NCT00268476)
- Author
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Sydes, M.R., primary, Mason, M.D., additional, Spears, M.R., additional, Clarke, N.W., additional, Dearnaley, D., additional, Ritchie, A.W.S., additional, Russell, M., additional, Gilson, C., additional, Jones, R., additional, de Bono, J., additional, Gillessen, S., additional, Millman, R., additional, Tolan, S., additional, Wagstaff, J., additional, Chowdhury, S., additional, Lester, J., additional, Sheehan, D., additional, Gale, J., additional, Parmar, M.K., additional, and James, N.D., additional
- Published
- 2017
- Full Text
- View/download PDF
31. LBA5_PR - Radiotherapy (RT) to the primary tumour for men with newly-diagnosed metastatic prostate cancer (PCa): Survival results from STAMPEDE
- Author
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Parker, C.C., James, N.D., Brawley, C., Clarke, N.W., Attard, G., Chowdhury, S., Cross, W., Dearnaley, D.P., Gilson, C.E., Jones, R., Mason, M.D., Millman, R., Gillessen, S., Eswar, C., Gale, J., Lester, J., Sheehan, D., Tran, A., Parmar, M.K., and Sydes, M.R.
- Published
- 2018
- Full Text
- View/download PDF
32. Registered Replication Report
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Cheung, I., primary, Campbell, L., additional, LeBel, E. P., additional, Ackerman, R. A., additional, Aykutoğlu, B., additional, Bahník, Š., additional, Bowen, J. D., additional, Bredow, C. A., additional, Bromberg, C., additional, Caprariello, P. A., additional, Carcedo, R. J., additional, Carson, K. J., additional, Cobb, R. J., additional, Collins, N. L., additional, Corretti, C. A., additional, DiDonato, T. E., additional, Ellithorpe, C., additional, Fernández-Rouco, N., additional, Fuglestad, P. T., additional, Goldberg, R. M., additional, Golom, F. D., additional, Gündoğdu-Aktürk, E., additional, Hoplock, L. B., additional, Houdek, P., additional, Kane, H. S., additional, Kim, J. S., additional, Kraus, S., additional, Leone, C. T., additional, Li, N. P., additional, Logan, J. M., additional, Millman, R. D., additional, Morry, M. M., additional, Pink, J. C., additional, Ritchey, T., additional, Root Luna, L. M., additional, Sinclair, H. C., additional, Stinson, D. A., additional, Sucharyna, T. A., additional, Tidwell, N. D., additional, Uysal, A., additional, Vranka, M., additional, Winczewski, L. A., additional, and Yong, J. C., additional
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- 2016
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33. The fabrication of ceramic-coated carbon fibre duplex elements
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Chappell, M. J. and Millman, R. S.
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- 1974
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34. The application of self adjusting interfaces to the design of fibrous composites
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Morley, J. G. and Millman, R. S.
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- 1974
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35. 19LBA Docetaxel (Doc) +/− zoledronic acid (ZA) for hormone-naive prostate cancer: First overall survival results from STAMPEDE & treatment effects within subgroups (NCT00268476)
- Author
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James, N.D., primary, Sydes, M.R., additional, Mason, M.D., additional, Clarke, N.W., additional, Dearnaley, D.P., additional, Spears, M.R., additional, Millman, R., additional, Parker, C.C., additional, Ritchie, A.W.S., additional, Russell, J.M., additional, Staffurth, J., additional, Jones, R.J., additional, Cathomas, R., additional, Robinson, A., additional, Chowdhury, S., additional, Tsang, D., additional, Brock, S., additional, Parikh, O., additional, Graham, J.D., additional, and Parmar, M.K.B., additional
- Published
- 2015
- Full Text
- View/download PDF
36. Magnetoencephalography to investigate central perception of exercise-induced breathlessness in people with chronic lung disease: a feasibility pilot
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Johnson, M. J., primary, Simpson, M. I., additional, Currow, D. C., additional, Millman, R. E., additional, Hart, S. P., additional, and Green, G., additional
- Published
- 2015
- Full Text
- View/download PDF
37. LBA31_PR - Adding abiraterone acetate plus prednisolone (AAP) or docetaxel for patients (pts) with high-risk prostate cancer (PCa) starting long-term androgen deprivation therapy (ADT): Directly randomised data from STAMPEDE (NCT00268476)
- Author
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Sydes, M.R., Mason, M.D., Spears, M.R., Clarke, N.W., Dearnaley, D., Ritchie, A.W.S., Russell, M., Gilson, C., Jones, R., de Bono, J., Gillessen, S., Millman, R., Tolan, S., Wagstaff, J., Chowdhury, S., Lester, J., Sheehan, D., Gale, J., Parmar, M.K., and James, N.D.
- Published
- 2017
- Full Text
- View/download PDF
38. O9 Survival with newly-diagnosed metastatic prostate cancer in the “docetaxel era”: Data from around 700 patients in the control arm of the STAMPEDE trial (NCT00268476)
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James, N.D., primary, Clarke, N.W., additional, Mason, M.D., additional, Spears, M.R., additional, Aebersold, D., additional, Dearnaley, D.P., additional, De Bono, J.S., additional, Millman, R., additional, Parker, C.C., additional, Parmar, M.K.B., additional, Ritchie, A.W.S., additional, Russell, M., additional, Thalmann, G.N., additional, and Sydes, M.R., additional
- Published
- 2013
- Full Text
- View/download PDF
39. Second-order modulation detection thresholds for pure-tone and narrow-band noise carriers
- Author
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Lorenzi, C., primary, Simpson, M. I. G., additional, Millman, R. E., additional, Griffiths, T. D., additional, Woods, W. P., additional, Rees, A., additional, and Green, G. G. R., additional
- Published
- 2001
- Full Text
- View/download PDF
40. Psychiatric Comorbidity in Methadone Maintained Patients
- Author
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Mason, B. J., primary, Kocsis, J. H., additional, Melia, D., additional, Khuri, E. T., additional, Sweeney, J., additional, Wells, A., additional, Borg, L., additional, Millman, R. B., additional, and Kreek, M. J., additional
- Published
- 1998
- Full Text
- View/download PDF
41. A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the Sleep AHEAD study.
- Author
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Foster GD, Borradaile KE, Sanders MH, Millman R, Zammit G, Newman AB, Wadden TA, Kelley D, Wing RR, Pi-Sunyer FX, Reboussin D, Kuna ST, and Sleep AHEAD Research Group of Look AHEAD Research Group
- Published
- 2009
- Full Text
- View/download PDF
42. Local antibody production and respiratory syncytial virus infection in children with leukaemia
- Author
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Taylor, C. E., primary, Craft, A. W., additional, Kernahan, J., additional, Millman, R., additional, Reid, M. M., additional, Scott, R., additional, and Toms, G. L., additional
- Published
- 1990
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- View/download PDF
43. The History of Management Thought.
- Author
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Millman, R. William
- Subjects
MANAGEMENT education ,THEORY-practice relationship ,SCHOLARS ,THEORISTS ,MANAGERIAL economics ,DECISION theory ,INDUSTRIAL management education ,STRATEGIC planning ,INDUSTRIAL productivity ,EDUCATION - Abstract
The article presents the results of a workshop on the history of management thought. Panelists were asked to discuss those individuals who have contributed the most to the practice of management, subsequent theory formation, and research of management. Conversation focused on the contributions of Alfred Sloan, Mary Parker Follett, Sune Carlson, Whiting Williams, William Foote Whyte, Alexander Leighton, and Fred Fiedler, among many others. The author finds that the informal discussion also led to conversations around the scope of management science, the interrelationship of management with other disciplines, how the development of management thought contributes to today's concerns, and whether management theory can exist independently of value systems, culture, and institutions.
- Published
- 1969
- Full Text
- View/download PDF
44. Comparative Views on Behavioral Science Findings.
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Lundberg, Craig C. and Millman, R. William
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SOCIAL sciences & management ,MANAGEMENT science research ,SOCIAL science research ,ORGANIZATIONAL behavior ,ORGANIZATIONAL effectiveness ,INDUSTRIAL management research ,PSYCHOLOGICAL research ,BEHAVIORAL research ,KNOWLEDGE gap theory ,INTERPROFESSIONAL relations ,INTELLECTUAL cooperation - Abstract
A study is presented that examines the extent to which the ideas and practices of individuals in managerial positions are congruent with the findings in behavioral science. The author aims to assess the effectiveness of the social and behavioral sciences in the field of management due to their increased popularity in research. The author notes that research in these areas has been increasing dramatically; however, the application of that research, by managers, does not appear to have matched the pace of researchers. The author discusses several possibilities for this, noting that gaps in communication between the two groups and differing areas of focus may help explain the problem.
- Published
- 1967
- Full Text
- View/download PDF
45. A General Systems approach to the Analysis of Managerial Functions.
- Author
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MILLMAN, R. WILLIAM
- Subjects
INDUSTRIAL management ,TRADITION (Philosophy) ,ORGANIZATION ,MANAGEMENT ,COMMUNICATION in management ,ORGANIZATIONAL behavior ,COMPETITION ,MANAGEMENT communication systems ,STRATEGIC planning ,ORGANIZATIONAL goals ,TELECOMMUNICATION systems ,MANAGEMENT science - Abstract
The need for an alternative approach to the analysis of managerial functions arises front the inherent limitations of the "traditional approach.'' (1) The traditionalists have not distinguished between true principles or facts and recommendations about what practice should be. (2) The validity of the "traditional approach" and its conclusions has not been demonstrated. (3) The acceptability of the approach and its conclusions rests in large measure upon frequent repetition by writers in the field. (4) The universality of application sought by the traditionalists is retarded by the very nature of their approach. These limitations impair the effectiveness and weaken the contribution of the traditional analysis. [ABSTRACT FROM AUTHOR]
- Published
- 1962
- Full Text
- View/download PDF
46. Simple predictors of uvulopalatopharyngoplasty outcome in the treatment of obstructive sleep apnea.
- Author
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Millman, Richard P., Carlisle, Carol C., Rosenberg, Cynthia, Kahn, Douglas, McRae, Robert, Kramer, Naomi R., Millman, R P, Carlisle, C C, Rosenberg, C, Kahn, D, McRae, R, and Kramer, N R
- Subjects
SLEEP apnea syndromes ,PHARYNX surgery ,POLYSOMNOGRAPHY - Abstract
Study Objective: Our objective was to determine whether baseline polysomnography, cephalometry, and anthropometry data could predict uvulopalatopharyngoplasty (UPPP) success or failure.Design: We retrospectively reviewed polysomnography, cephalometry, and anthropometry data from patients who underwent UPPP for obstructive sleep apnea (OSA).Setting: A university medical center.Patients: OSA was diagnosed by polysomnography in 46 patients who underwent UPPP surgery for their sleep disorder.Interventions: UPPP surgery with/or without tonsillectomy.Measurements and Results: The mean patient age was 43 years, and the mean body mass index was 32.5 kg/m(2). The mean presurgical apnea-hypopnea index (AHI) was 45, and the mean baseline nadir oxygen saturation was 81%. Successful surgery was defined as a reduction in AHI to < 10 or to < 20 with a 50% reduction from the patient's baseline AHI. Of the 46 patients, 16 were successfully treated and 30 did not respond to surgical treatment. A mandibular-hyoid distance (MP-H) > 20 mm was found to be significantly (p = 0.05) predictive of failure of UPPP. When stepwise regression analysis was performed utilizing postsurgical AHI as the dependent variable and presurgical AHI, age, body mass index, baseline nadir O(2) saturation, and five cephalometric measurements as independent variables, MP-H distance significantly (r = 0.524; p = 0.01) correlated positively with postsurgical AHI. The distance between the superior point of a line-constructed plane of the sphenoidale (parallel to Frankfort horizontal) and a point at the intersection of the palatal plane perpendicular to the hyoid correlated negatively with postsurgical AHI (r = 0.586; p = 0.05). By creating a logistic model of this data, an MP-H distance < 21 mm, an angle created by point A to the nasion to point B < 3 degrees, and the presence of a baseline AHI < 38 enhanced the predictability of UPPP success.Conclusions: The presence of a baseline AHI < 38 and an MP-H < or = 20 mm, and the absence of retrognathia are predictors of improvement after UPPP. Based on these findings, we would advocate the continued evaluation of cephalometric measurements and careful consideration of surgical treatment options for OSA. [ABSTRACT FROM AUTHOR]- Published
- 2000
- Full Text
- View/download PDF
47. Alcohol Use in Youthful Methadone-Maintained Former Heroin Addicts: Liver Impairment and Treatment Outcome.
- Author
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Hartman, N., Kreek, M. J., Ross, A., Khuri, E., Millman, R. B., and Rodriguez, R.
- Abstract
Combined alcohol abuse and narcotic dependency is now recognized as a common problem in adults but has not been well characterized in adolescents, nor have the effects of combined substance abuse on liver function in this age group been assessed. Forty-four youthful former heroin addicts (27 males (M) and 17 females (F)) on methadone maintenance therapy were interviewed in detail about past and present alcohol use and underwent physical examination. Liver function studies and tests for hepatitis B antigen and antibody were performed. Four and onehalf years later, 28 of these patients still in treatment or willing to return for study purposes were similarly reevaluated. The original sample included 15 whose alcohol intake was high (12 M + 3 F: group A) and 29 whose intake was low or absent (15 M + 14 F: group N). Sixty-six per cent of group A patients and 58% of group N patients remained in treatment at the second time point. Group A had significantly greater abnormalities in liver function than group N with evidence of progression over 4 1/2 years, based both on physical examination and blood chemistry results. Seventy-five per cent of the patients had evidence of exposure to hepatitis B virus (anti HB. positive) in 1981 while 7% demonstrated antigenemia. The results demonstrate that: (1) alcohol abuse is common among adolescents and young adults in methadone maintenance therapy; (2) that it is associated with significant acute or chronic liver impairment; (3) exposure to HE virus is endemic in youthful former heroin addicts; and (4) the retention of alcohol-abusing patients in methadone treatment and drug-free follow-up is as great as with non-alcohol abusing patients. [ABSTRACT FROM AUTHOR]
- Published
- 1983
- Full Text
- View/download PDF
48. Abnormalities in the flow-volume loop in obstructive sleep apnoea sitting and supine.
- Author
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Shore, E T and Millman, R P
- Abstract
We evaluated the effect of posture on the sensitivity and specificity of abnormalities in the flow-volume loop in 30 patients with suspected obstructive sleep apnoea. Flow-volume loops were judged as abnormal if the FEF50/FIF50 ratio was greater than 1 or if the sawtooth sign was judged to be present by at least two of three chest physicians. Detailed nocturnal recordings confirmed the presence of obstructive sleep apnoea in 17 of the 30 patients. Our results showed that both the sensitivity and the specificity of each of the flow-volume criteria for the diagnosis of obstructive sleep apnoea were higher when the loops were recorded in the supine than when they were recorded in the sitting position. The sensitivities were low, however, even with the supine posture--sawtoothing 41% and FEF50/FIF50 ratio greater than 1 47%. The highest sensitivity (71%) was obtained by considering a positive result as being the presence of either of the abnormalities in either the sitting or the supine posture. This sensitivity of the flow-volume loop was too low to recommend it as a routine screening test for the diagnosis of obstructive sleep apnoea but the presence of the sawtooth sign had a high specificity (92%) for the diagnosis of obstructive sleep apnoea. Furthermore, there was a greater fall in oxygen saturation in patients with apnoea who had sawtoothing than in those without sawtoothing. The presence of the sawtooth sign should increase the suspicion of sleep apnoea and suggest the need for further investigation. The effect of posture on the occurrence of abnormalities in the flow-volume loop suggests that position alters the configuration of the upper airway. [ABSTRACT FROM AUTHOR]
- Published
- 1984
49. Effect of aging on ventilatory response to exercise and CO2.
- Author
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BRISCHETTO, M. J., MILLMAN, R. P., PETERSON, D. D., SILAGE, D. A., and PACK, A. I.
- Published
- 1984
- Full Text
- View/download PDF
50. A preliminary investigation of the properties of plastically-deforming two-part composite reinforcement.
- Author
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Millman, R S and Morley, J G
- Published
- 1975
- Full Text
- View/download PDF
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