952 results on '"Miller, Rachel L"'
Search Results
2. Development and Psychometric Validation of the Pandemic-Related Traumatic Stress Scale for Children and Adults
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Blackwell, Courtney K, Sherlock, Phillip, Jackson, Kathryn L, Hofheimer, Julie A, Cella, David, Algermissen, Molly A, Alshawabkeh, Akram N, Avalos, Lyndsay A, Bastain, Tracy, Blair, Clancy, Enlow, Michelle Bosquet, Brennan, Patricia A, Breton, Carrie, Bush, Nicole R, Chandran, Aruna, Collazo, Shaina, Conradt, Elisabeth, Crowell, Sheila E, Deoni, Sean, Elliott, Amy J, Frazier, Jean A, Ganiban, Jody M, Gold, Diane R, Herbstman, Julie B, Joseph, Christine, Karagas, Margaret R, Lester, Barry, Lasky-Su, Jessica A, Leve, Leslie D, LeWinn, Kaja Z, Mason, W Alex, McGowan, Elisabeth C, McKee, Kimberly S, Miller, Rachel L, Neiderhiser, Jenae M, O’Connor, Thomas G, Oken, Emily, O’Shea, T Michael, Pagliaccio, David, Schmidt, Rebecca J, Singh, Anne Marie, Stanford, Joseph B, Trasande, Leonardo, Wright, Rosalind J, Duarte, Cristiane S, and Margolis, Amy E
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Clinical and Health Psychology ,Social and Personality Psychology ,Psychology ,Behavioral and Social Science ,Clinical Research ,Mental Health ,Pediatric ,Brain Disorders ,Depression ,Neurosciences ,Pediatric Research Initiative ,Aetiology ,2.3 Psychological ,social and economic factors ,Mental health ,Good Health and Well Being ,United States ,Adolescent ,Pregnancy ,Humans ,Adult ,Child ,Female ,Male ,Pandemics ,Psychometrics ,Reproducibility of Results ,Anxiety ,Anxiety Disorders ,COVID-19 ,traumatic stress ,pandemic ,survey ,Mokken scaling ,Business and Management ,Cognitive Sciences ,Clinical Psychology ,Applied and developmental psychology ,Cognitive and computational psychology ,Social and personality psychology - Abstract
To assess the public health impact of the COVID-19 pandemic on mental health, investigators from the National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) research program developed the Pandemic-Related Traumatic Stress Scale (PTSS). Based on the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) acute stress disorder symptom criteria, the PTSS is designed for adolescent (13-21 years) and adult self-report and caregiver-report on 3-12-year-olds. To evaluate psychometric properties, we used PTSS data collected between April 2020 and August 2021 from non-pregnant adult caregivers (n = 11,483), pregnant/postpartum individuals (n = 1,656), adolescents (n = 1,795), and caregivers reporting on 3-12-year-olds (n = 2,896). We used Mokken scale analysis to examine unidimensionality and reliability, Pearson correlations to evaluate relationships with other relevant variables, and analyses of variance to identify regional, age, and sex differences. Mokken analysis resulted in a moderately strong, unidimensional scale that retained nine of the original 10 items. We detected small to moderate positive associations with depression, anxiety, and general stress, and negative associations with life satisfaction. Adult caregivers had the highest PTSS scores, followed by adolescents, pregnant/postpartum individuals, and children. Caregivers of younger children, females, and older youth had higher PTSS scores compared to caregivers of older children, males, and younger youth, respectively. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
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- 2023
3. The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort
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Knapp, Emily A, Kress, Amii M, Parker, Corette B, Page, Grier P, McArthur, Kristen, Gachigi, Kennedy K, Alshawabkeh, Akram N, Aschner, Judy L, Bastain, Theresa M, Breton, Carrie V, Bendixsen, Casper G, Brennan, Patricia A, Bush, Nicole R, Buss, Claudia, Camargo, Carlos A, Catellier, Diane, Cordero, José F, Croen, Lisa, Dabelea, Dana, Deoni, Sean, D’Sa, Viren, Duarte, Cristiane S, Dunlop, Anne L, Elliott, Amy J, Farzan, Shohreh F, Ferrara, Assiamira, Ganiban, Jody M, Gern, James E, Giardino, Angelo P, Towe-Goodman, Nissa R, Gold, Diane R, Habre, Rima, Hamra, Ghassan B, Hartert, Tina, Herbstman, Julie B, Hertz-Picciotto, Irva, Hipwell, Alison E, Karagas, Margaret R, Karr, Catherine J, Keenan, Kate, Kerver, Jean M, Koinis-Mitchell, Daphne, Lau, Bryan, Lester, Barry M, Leve, Leslie D, Leventhal, Bennett, LeWinn, Kaja Z, Lewis, Johnnye, Litonjua, Augusto A, Lyall, Kristen, Madan, Juliette C, McEvoy, Cindy T, McGrath, Monica, Meeker, John D, Miller, Rachel L, Morello-Frosch, Rachel, Neiderhiser, Jenae M, O’Connor, Thomas G, Oken, Emily, O’Shea, Michael, Paneth, Nigel, Porucznik, Christina A, Sathyanarayana, Sheela, Schantz, Susan L, Spindel, Eliot R, Stanford, Joseph B, Stroustrup, Annemarie, Teitelbaum, Susan L, Trasande, Leonardo, Volk, Heather, Wadhwa, Pathik D, Weiss, Scott T, Woodruff, Tracey J, Wright, Rosalind J, Zhao, Qi, Jacobson, Lisa P, and Outcomes, on behalf of program collaborators for Environmental Influences on Child Health
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Public Health ,Health Sciences ,Human Genome ,Prevention ,Nutrition ,Pediatric ,Behavioral and Social Science ,Genetics ,Clinical Research ,Pediatric Research Initiative ,2.2 Factors relating to the physical environment ,Aetiology ,Good Health and Well Being ,Child ,Humans ,United States ,Environmental Exposure ,Cohort Studies ,Child Health ,Air Pollution ,Outcome Assessment ,Health Care ,adolescent ,child ,child development ,child health ,child well-being ,cohort studies ,environmental exposure ,epidemiologic methods ,Mathematical Sciences ,Medical and Health Sciences ,Epidemiology - Abstract
The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of Health (NIH) in 2016 to improve children's health in the United States. The EWC harmonizes extant data and collects new data using a standardized protocol, the ECHO-Wide Cohort Data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but the frequency and timing of the visits vary across cohorts. As of March 4, 2022, the EWC cohorts contributed data from 60,553 children and consented 29,622 children for new EWCP data and biospecimen collection. The median (interquartile range) age of EWCP-enrolled children was 7.5 years (3.7-11.1). Surveys, interviews, standardized examinations, laboratory analyses, and medical record abstraction are used to obtain information in 5 main outcome areas: pre-, peri-, and postnatal outcomes; neurodevelopment; obesity; airways; and positive health. Exposures include factors at the level of place (e.g., air pollution, neighborhood socioeconomic status), family (e.g., parental mental health), and individuals (e.g., diet, genomics).
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- 2023
4. Synthetic Chemicals: What We Have Learned and Still Need to Learn About Their Associations with Childhood Allergy and Asthma
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Shah, Ami and Miller, Rachel L.
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- 2023
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5. Trajectory analysis of rhinitis in a birth cohort from lower-income New York City neighborhoods
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Flores, Nina M., Lovinsky-Desir, Stephanie, Divjan, Adnan, Hoepner, Lori A., Zou, Jungang, Miller, Rachel L., Herbstman, Julie B., Perera, Frederica P., Perzanowski, Matthew S., and Chen, Qixuan
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- 2024
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6. The Role of Childhood Asthma in Obesity Development
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Stratakis, Nikos, Garcia, Erika, Chandran, Aruna, Hsu, Tingju, Alshawabkeh, Akram, Aris, Izzuddin M, Aschner, Judy L, Breton, Carrie, Burbank, Allison, Camargo, Carlos A, Carroll, Kecia N, Chen, Zhanghua, Claud, Erika C, Dabelea, Dana, Dunlop, Anne L, Elliott, Amy J, Ferrara, Assiamira, Ganiban, Jody M, Gern, James E, Gold, Diane R, Gower, William A, Hertz-Picciotto, Irva, Karagas, Margaret R, Karr, Catherine J, Lester, Barry, Leve, Leslie D, Litonjua, Augusto A, Ludena, Yunin, McEvoy, Cindy T, Miller, Rachel L, Mueller, Noel T, O’Connor, Thomas G, Oken, Emily, O’Shea, T Michael, Perera, Frederica, Stanford, Joseph B, Rivera-Spoljaric, Katherine, Rundle, Andrew, Trasande, Leonardo, Wright, Rosalind J, Zhang, Yue, Zhu, Yeyi, Berhane, Kiros, Gilliland, Frank, and Chatzi, Lida
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Epidemiology ,Public Health ,Health Sciences ,Pediatric ,Asthma ,Nutrition ,Prevention ,Clinical Research ,Obesity ,Pediatric Research Initiative ,Lung ,Aetiology ,2.4 Surveillance and distribution ,2.1 Biological and endogenous factors ,Respiratory ,Metabolic and endocrine ,Adolescent ,Body Mass Index ,Child ,Female ,Humans ,Incidence ,Male ,Pediatric Obesity ,Proportional Hazards Models ,Risk Factors ,asthma ,obesity ,childhood ,asthma medication ,ECHO ,on behalf of program collaborators for Environmental Influences on Child Health Outcomes ,Statistics ,Public Health and Health Services ,Public health - Abstract
RationaleAsthma and obesity often co-occur. It has been hypothesized that asthma may contribute to childhood obesity onset.ObjectivesTo determine if childhood asthma is associated with incident obesity and examine the role of asthma medication in this association.MethodsWe studied 8,716 children between ages 6 and 18.5 years who were nonobese at study entry participating in 18 US cohorts of the Environmental influences on Child Health Outcomes program (among 7,299 children with complete covariate data mean [SD] study entry age = 7.2 [1.6] years and follow up = 5.3 [3.1] years).Measurements and main resultsWe defined asthma based on caregiver report of provider diagnosis. Incident obesity was defined as the first documented body mass index ≥95th percentile for age and sex following asthma status ascertainment. Over the study period, 26% of children had an asthma diagnosis and 11% developed obesity. Cox proportional hazards models with sex-specific baseline hazards were fitted to assess the association of asthma diagnosis with obesity incidence. Children with asthma had a 23% (95% confidence intervals [CI] = 4, 44) higher risk for subsequently developing obesity compared with those without asthma. A novel mediation analysis was also conducted to decompose the total asthma effect on obesity into pathways mediated and not mediated by asthma medication use. Use of asthma medication attenuated the total estimated effect of asthma on obesity by 64% (excess hazard ratios = 0.64; 95% CI = -1.05, -0.23).ConclusionsThis nationwide study supports the hypothesis that childhood asthma is associated with later risk of obesity. Asthma medication may reduce this association and merits further investigation as a potential strategy for obesity prevention among children with asthma.
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- 2022
7. Home and school pollutant exposure, respiratory outcomes, and influence of historical redlining
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Jung, Kyung Hwa, Argenio, Kira L., Jackson, Daniel J., Miller, Rachel L., Perzanowski, Matthew S., Rundle, Andrew G., Bacharier, Leonard B., Busse, William W., Cohen, Robyn T., Visness, Cynthia M., Gill, Michelle A., Gruchalla, Rebecca S., Hershey, Gurjit K., Kado, Rachel K., Sherenian, Michael G., Liu, Andrew H., Makhija, Melanie M., Pillai, Dinesh K., Rivera-Spoljaric, Katherine, Gergen, Peter J., Altman, Matthew C., Sandel, Megan T., Sorkness, Christine A., Kattan, Meyer, and Lovinsky-Desir, Stephanie
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- 2024
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8. Exploring the evidence for epigenetic regulation of environmental influences on child health across generations.
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Breton, Carrie V, Landon, Remy, Kahn, Linda G, Enlow, Michelle Bosquet, Peterson, Alicia K, Bastain, Theresa, Braun, Joseph, Comstock, Sarah S, Duarte, Cristiane S, Hipwell, Alison, Ji, Hong, LaSalle, Janine M, Miller, Rachel L, Musci, Rashelle, Posner, Jonathan, Schmidt, Rebecca, Suglia, Shakira F, Tung, Irene, Weisenberger, Daniel, Zhu, Yeyi, and Fry, Rebecca
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Animals ,Humans ,Obesity ,Birth Weight ,Environmental Exposure ,DNA Methylation ,Epigenesis ,Genetic ,Respiration ,Child ,Child Health ,Human Genome ,Genetics ,Pediatric ,Behavioral and Social Science ,Pediatric Research Initiative ,Basic Behavioral and Social Science ,Prevention ,2.2 Factors relating to the physical environment ,2.3 Psychological ,social and economic factors ,Generic health relevance - Abstract
Environmental exposures, psychosocial stressors and nutrition are all potentially important influences that may impact health outcomes directly or via interactions with the genome or epigenome over generations. While there have been clear successes in large-scale human genetic studies in recent decades, there is still a substantial amount of missing heritability to be elucidated for complex childhood disorders. Mounting evidence, primarily in animals, suggests environmental exposures may generate or perpetuate altered health outcomes across one or more generations. One putative mechanism for these environmental health effects is via altered epigenetic regulation. This review highlights the current epidemiologic literature and supporting animal studies that describe intergenerational and transgenerational health effects of environmental exposures. Both maternal and paternal exposures and transmission patterns are considered, with attention paid to the attendant ethical, legal and social implications.
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- 2021
9. Associations between mitochondrial biomarkers, urban residential exposures and childhood asthma outcomes over 6 months
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Miller, Rachel L., Rivera, Janelle, Lichtiger, Lydia, Govindarajulu, Usha S., Jung, Kyung Hwa, Lovinsky-Desir, Stephanie, Perera, Frederica, Balcer Whaley, Susan, Newman, Michelle, Grant, Torie L., McCormack, Meredith, Perzanowski, Matthew, and Matsui, Elizabeth C.
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- 2023
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10. Fungal diversity in homes and asthma morbidity among school-age children in New York City
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Cochran, Samuel J., Acosta, Luis, Divjan, Adnan, Lemons, Angela R., Rundle, Andrew G., Miller, Rachel L., Sobek, Edward, Green, Brett J., Perzanowski, Matthew S., and Dannemiller, Karen C.
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- 2023
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11. Prenatal airborne polycyclic aromatic hydrocarbon exposure, altered regulation of peroxisome proliferator-activated receptor gamma (Ppar)γ, and links with mammary cancer
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Lichtiger, Lydia, Jezioro, Jacqueline, Rivera, Janelle, McDonald, Jacob D., Terry, Mary Beth, Sahay, Debashish, and Miller, Rachel L.
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- 2023
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12. Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program
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Smith, P.B., Newby, K.L., Jacobson, L.P., Catellier, D.J., Gershon, R., Cella, D., Alshawabkeh, A., Aschner, J., Merhar, S., Ren, C., Reynolds, A., Keller, R., Pryhuber, G., Duncan, A., Lampland, A., Wadhawan, R., Wagner, C., Hudak, M., Mayock, D., Walshburn, L., Teitelbaum, S.L., Stroustrup, A., Trasande, L., Blair, C., Gatzke-Kopp, L., Swingler, M., Mansbach, J., Spergel, J., Puls, H., Stevenson, M., Bauer, C., Deoni, S., Duarte, C., Dunlop, A., Elliott, A., Croen, L., Bacharier, L., O’Connor, G., Kattan, M., Wood, R., Hershey, G., Ownby, D., Hertz-Picciotto, I., Hipwell, A., Karagas, M., Karr, C., Mason, A., Sathyanarayana, S., Lester, B., Carter, B., Neal, C., Smith, L., Helderman, J., Leve, L., Ganiban, J., Neiderhiser, J., Weiss, S., Zeiger, R., Tepper, R., Lyall, K., Landa, R., Ozonoff, S., Schmidt, R., Dager, S., Schultz, R., Piven, J., Volk, H., Vaidya, R., Obeid, R., Rollins, C., Bear, K., Pastyrnak, S., Lenski, M., Msall, M., Frazier, J., Washburn, L., Montgomery, A., Barone, C., McKane, P., Paneth, N., Elliott, M., Herbstman, J., Schantz, S., Porucznik, C., Silver, R., Conradt, E., Bosquet-Enlow, M., Huddleston, K., Bush, N., Nguyen, R., O'Connor, T., Samuels-Kalow, M., Miller, Rachel L., Schuh, Holly, Chandran, Aruna, Aris, Izzuddin M., Bendixsen, Casper, Blossom, Jeffrey, Breton, Carrie, Camargo, Carlos A., Jr., Canino, Glorisa, Carroll, Kecia N., Commodore, Sarah, Cordero, José F., Dabelea, Dana M., Ferrara, Assiamira, Fry, Rebecca C., Ganiban, Jody M., Gern, James E., Gilliland, Frank D., Gold, Diane R., Habre, Rima, Hare, Marion E., Harte, Robyn N., Hartert, Tina, Hasegawa, Kohei, Khurana Hershey, Gurjit K., Jackson, Daniel J., Joseph, Christine, Kerver, Jean M., Kim, Haejin, Litonjua, Augusto A., Marsit, Carmen J., McEvoy, Cindy, Mendonça, Eneida A., Moore, Paul E., Nkoy, Flory L., O’Connor, Thomas G., Oken, Emily, Ownby, Dennis, Perzanowski, Matthew, Rivera-Spoljaric, Katherine, Ryan, Patrick H., Singh, Anne Marie, Stanford, Joseph B., Wright, Rosalind J., Wright, Robert O., Zanobetti, Antonella, Zoratti, Edward, and Johnson, Christine C.
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- 2023
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13. Cancer Risk Reduction Through Education of Adolescents: Development of a Tailored Cancer Risk-Reduction Educational Tool
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Zeinomar, Nur, Grant-Alfieri, Amelia, Burke, Kimberly R., de Hoz, Milagros, Tehranifar, Parisa, Walker, Desiree A. H., Morton, Taylor, Shepard, Peggy, Herbstman, Julie B., Miller, Rachel L., Perera, Frederica, and Terry, Mary Beth
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- 2022
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14. Asthma Epigenetics: Elucidating an Expanding Paradigm
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Miller, Rachel L., Chen, James, and Michels, Karin B., editor
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- 2022
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15. Spring is associated with increased total and allergenic fungal concentrations in house dust from a pediatric asthma cohort in New York City
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Cochran, Samuel J., Acosta, Luis, Divjan, Adnan, Lemons, Angela R., Rundle, Andrew G., Miller, Rachel L., Sobek, Edward, Green, Brett J., Perzanowski, Matthew S., and Dannemiller, Karen C.
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- 2022
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16. Impact of SARS-CoV-2 lockdown on expansion of HIV transmission clusters among key populations: A retrospective phylogenetic analysis
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Miller, Rachel L., McLaughlin, Angela, Montoya, Vincent, Toy, Junine, Stone, Sarah, Harding, John, Liang, Richard H., Wong, Jason, Barrios, Rolando, Montaner, Julio S.G., and Joy, Jeffrey B.
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- 2022
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17. Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research.
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Terry, Mary Beth, Michels, Karin B, Brody, Julia Green, Byrne, Celia, Chen, Shiuan, Jerry, D Joseph, Malecki, Kristen MC, Martin, Mary Beth, Miller, Rachel L, Neuhausen, Susan L, Silk, Kami, Trentham-Dietz, Amy, and Breast Cancer and the Environment Research Program (BCERP)
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Breast Cancer and the Environment Research Program ,Animals ,Humans ,Breast Neoplasms ,Disease Susceptibility ,Risk Factors ,Environmental Exposure ,Maternal Exposure ,Pregnancy ,Menopause ,Puberty ,Research ,Time Factors ,Female ,Breast neoplasms ,Environment ,Pediatric Research Initiative ,Aging ,Prevention ,Breast Cancer ,Cancer ,Estrogen ,2.2 Factors relating to the physical environment ,Oncology & Carcinogenesis ,Oncology and Carcinogenesis - Abstract
BackgroundThe long time from exposure to potentially harmful chemicals until breast cancer occurrence poses challenges for designing etiologic studies and for implementing successful prevention programs. Growing evidence from animal and human studies indicates that distinct time periods of heightened susceptibility to endocrine disruptors exist throughout the life course. The influence of environmental chemicals on breast cancer risk may be greater during several windows of susceptibility (WOS) in a woman's life, including prenatal development, puberty, pregnancy, and the menopausal transition. These time windows are considered as specific periods of susceptibility for breast cancer because significant structural and functional changes occur in the mammary gland, as well as alterations in the mammary micro-environment and hormone signaling that may influence risk. Breast cancer research focused on these breast cancer WOS will accelerate understanding of disease etiology and prevention.Main textDespite the plausible heightened mechanistic influences of environmental chemicals on breast cancer risk during time periods of change in the mammary gland's structure and function, most human studies of environmental chemicals are not focused on specific WOS. This article reviews studies conducted over the past few decades that have specifically addressed the effect of environmental chemicals and metals on breast cancer risk during at least one of these WOS. In addition to summarizing the broader evidence-base specific to WOS, we include discussion of the NIH-funded Breast Cancer and the Environment Research Program (BCERP) which included population-based and basic science research focused on specific WOS to evaluate associations between breast cancer risk and particular classes of endocrine-disrupting chemicals-including polycyclic aromatic hydrocarbons, perfluorinated compounds, polybrominated diphenyl ethers, and phenols-and metals. We outline ways in which ongoing transdisciplinary BCERP projects incorporate animal research and human epidemiologic studies in close partnership with community organizations and communication scientists to identify research priorities and effectively translate evidence-based findings to the public and policy makers.ConclusionsAn integrative model of breast cancer research is needed to determine the impact and mechanisms of action of endocrine disruptors at different WOS. By focusing on environmental chemical exposure during specific WOS, scientists and their community partners may identify when prevention efforts are likely to be most effective.
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- 2019
18. Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma
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Prunicki, Mary, Stell, Laurel, Dinakarpandian, Deendayal, de Planell-Saguer, Mariangels, Lucas, Richard W, Hammond, S Katharine, Balmes, John R, Zhou, Xiaoying, Paglino, Tara, Sabatti, Chiara, Miller, Rachel L, and Nadeau, Kari C
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Biological Sciences ,Genetics ,Asthma ,Lung ,Clinical Research ,Prevention ,2.1 Biological and endogenous factors ,Aetiology ,Adolescent ,California ,Carbon Monoxide ,CpG Islands ,DNA Methylation ,Epigenesis ,Genetic ,Female ,Forkhead Transcription Factors ,Gene Expression Regulation ,Genetic Association Studies ,Humans ,Interleukin-10 ,Introns ,Male ,Nitrogen Dioxide ,Particulate Matter ,Promoter Regions ,Genetic ,Ambient air pollution ,Immune system ,Regulatory T cell ,Epigenetics ,Clinical Sciences ,Paediatrics and Reproductive Medicine - Abstract
BackgroundDNA methylation of CpG sites on genetic loci has been linked to increased risk of asthma in children exposed to elevated ambient air pollutants (AAPs). Further identification of specific CpG sites and the pollutants that are associated with methylation of these CpG sites in immune cells could impact our understanding of asthma pathophysiology. In this study, we sought to identify some CpG sites in specific genes that could be associated with asthma regulation (Foxp3 and IL10) and to identify the different AAPs for which exposure prior to the blood draw is linked to methylation levels at these sites. We recruited subjects from Fresno, California, an area known for high levels of AAPs. Blood samples and responses to questionnaires were obtained (n = 188), and in a subset of subjects (n = 33), repeat samples were collected 2 years later. Average measures of AAPs were obtained for 1, 15, 30, 90, 180, and 365 days prior to each blood draw to estimate the short-term vs. long-term effects of the AAP exposures.ResultsAsthma was significantly associated with higher differentially methylated regions (DMRs) of the Foxp3 promoter region (p = 0.030) and the IL10 intronic region (p = 0.026). Additionally, at the 90-day time period (90 days prior to the blood draw), Foxp3 methylation was positively associated with NO2, CO, and PM2.5 exposures (p = 0.001, p = 0.001, and p = 0.012, respectively). In the subset of subjects retested 2 years later (n = 33), a positive association between AAP exposure and methylation was sustained. There was also a negative correlation between the average Foxp3 methylation of the promoter region and activated Treg levels (p = 0.039) and a positive correlation between the average IL10 methylation of region 3 of intron 4 and IL10 cytokine expression (p = 0.030).ConclusionsShort-term and long-term exposures to high levels of CO, NO2, and PM2.5 were associated with alterations in differentially methylated regions of Foxp3. IL10 methylation showed a similar trend. For any given individual, these changes tend to be sustained over time. In addition, asthma was associated with higher differentially methylated regions of Foxp3 and IL10.
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- 2018
19. Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study
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Achten, Niek, Ainsworth, John, Akkerman, Nonna, Anderson, Elizabeth, Anderson, Larry J., Andrews, Howard, Armagost, Elizabeth, Aubuchon, Mary Ann, Bach, Julia, Bacharier, Leonard, Barnes, Kathrine L., Barone, Charles, Bauer, Irma, Beamer, Paloma, Becker, Patrice, Bednarek, Alyssa, Bellemore, Stacey, Bendixsen, Casper G., Biagini Myers, Jocelyn M., Billheimer, Dean, Billstrand, Christine, Birg, Geraldine, Blocki, Shirley, Bloomberg, Gordon, Bobbitt, Kevin, Bochkov, Yury, Bourgeois, Karen, Boushey, Homer, Brockman-Schneider, Rebecca, Brunwasser, Steven M., Budrevich, Richard, Burkle, Jeffrey W., Busse, William, Calatroni, Agustin, Campbell, Janice, Carlson-Dakes, Kirsten, Cassidy-Bushrow, Andrea, Chappell, James D., Chasman, Deborah, Chipps, Teresa M., Chirkova, Tatiana, Cole, Deanna, Connolly, Alexandra, Cootauco, Michelle, Costello, Kaitlin, Couch, Philip, Coull, Brent, Craven, Mark, Crisafi, Gina, Cruikshank, William, Curtsinger, Kristi, Custovic, Adnan, Das, Suman R., DaSilva, Douglas, Datta, Soma, Davidson, Brent, De La Ossa, Lydia, DeVries, Mark, Di, Qian, Dixon, Samara, Donnerbauer, Erin, Dorst, Marian, Doyle, Susan, Dresen, Amy, Dupont, William D., Durrange, Janet, Erickson, Heidi, Evans, Michael D., Ezell, Jerel, Farnham, Leanna, Filardo-Collins, Roxanne, Finazzo, Salvatore, Flege, Zachary, Fleurat, Conner, Floerke, Heather, Floerke, Dorothy, Foss, Terry, Freie, Angela, Frome, Wayne, Fye, Samantha, Gagalis, Lisa, Gammell, Rebecca, Gangnon, Ronald E., Ge, James E., Gebretsadik, Tebeb, Gergen, Peter, Gern, James E., Gibson, Heike, Gjerasi, Edlira, Gold, Diane R., Gonzalez, Nicole, Goodman, Kayla, Gress, Lisa, Grindle, Kristine, Groeschen, Taylor, Hallmark, Brian, Halonen, Marilyn, Hart, Jaime, Hartert, Tina V., Havstad, Suzanne, Heinritz, Patrick, Hensley Alford, Sharon, Herbstman, Julie, Hernandez, Kellie, Hoepner, Lori, Jackson, Daniel J., Jadhao, Samadhan J., Jaffee, Katy, James, Peter, Jezioro, Jacqueline, Jimenez Pescador, Marcia, Johnson, Christine C., Johnson, Tara, Johnson, Camille, Jones, Amelia, Jones, Kyra, Jones, Paul, Jordan, Carolina, Joseph, Christine LM, Kattan, Meyer, Keidel, Kristina, Keifer, Matthew C., Kelley, Rick, Khurana Hershey, Gurgit K., Kim, Haejin, Kloog, Itai, Koepel, Tammy Kronenwetter, Koerkenmeier, Clint, Ladick, Laura, Lamm, Carin, Larkin, Emma, Lederman, Howard, Lee-Parritz, Aviva, Leimenstoll, Stephanie, Lemanske, Jr., Robert F., LeMasters, Grace K., Levin, Albert M., Levine, Jessica, Liu, Xinhua, Liu, Zhouwen, Lopez, Silvia, Lothrop, Nathan, Lovinsky-Desir, Stephanie, Lukacs, Nicholas, Lynch, Susan, Lynch, Christian, Mann, Erik, Martin, Jennifer, Martin, Lisa, Martinez, Fernando D., Matsui, Elizabeth, McCauley, Katherine, Mccollum, Megan, McCullough, Judith, McKennon, Chris G., Meece, Jennifer, Mendonca, Eneida, Mikus, Lance, Miller, Rachel L., Minton, Patricia, Mitchell, Herman, Moon, Vicki, Moore, Paul E., Morgan, Wayne, Morgan, Valerie, Morgan, David, Murrison, Liza, Nicholas, Charlotte, Nicolae, Daniel, Nunez, Adam, O'Connor, George, O'Toole, Sharon, Ober, Carole, Olson, Brent F., Ong, Irene, Osmundson, Sarah, Ownby, Dennis, Pappas, Tressa, Perera, Frederica, Perzanowski, Matthew, Peterson, Edward, Pierce, Marcela, Price-Johnson, Penny, Rajamanickam, Victoria, Ramirez, Judyth, Ray, Kimberly, Renneberg, Megan, Requia, Weeberb, Riley, Kylie, Rivera, Janelle, Rivers, Neisha, Roberg, Kathy, Rogers, Theresa, Rosas-Salazar, Christian, Russell, Pat, Ryan, Patrick H., Sadovsky, Yoel, Salazar, Lisa, Sampson, Hugh, Sandel, Megan, Schoettler, Nathan, Schwartz, Joel, Scott, Dena, Seroogy, Christine M., Sharp, Renee, Shilts, Meghan H., Sigelman, Steve, Singh, Anne Marie, Sitarik, Alexandra, Smartt, Ernestine, Sorkness, Ronald, Sorkness, Christine, Spangenberg, Amber, Sperling, Rhoda, Spies, David, Stern, Debra A., Stoffel, Brandy, Peebles, R. Stokes, Stouffer, Gina, Strauchman Boyer, Cathey, Suddeuth, Caitlin, Tachinardi, Umberto, Tang, Deliang, Tang, Zhengzheng, Tate, Jena, Taylor, William, Tensing, Krista, Tesson, Elizabeth, Thompson, Kathy, Thompson, Emma, Tisler, Christopher, Togias, Alkis, Turi, Kedir, Turner, Victoria, Tuzova, Marina, VanWormer, Jeffrey J., Visness, Cynthia M., Vrtis, Rose, Wahlman, Anthony, Wang, Lena, Wegienka, Ganesa, Wells, Karen, Wentworth-Sheilds, William, Wheatley, Lisa, Whitney, Nitsa, Williams, L. Keoki, Witter, Frank, Wolfe, Christopher, Wood, Robert A., Woodcroft, Kimberley, Woodward, Kim B., Wright, Anne L., Wright, Rosalind, Wu, Pingsheng, Yaeger, Melissa, Yaniv, Perri, Zanobetti, Antonella, Zhang, Shirley, Zook, Patricia, Zoratti, Edward M., McKennan, Chris G, Magnaye, Kevin M, Altman, Matthew C, Washington, Charles, 3rd, Stanhope, Catherine, Naughton, Katherine A, Rosasco, Mario G, Bacharier, Leonard B, Gold, Diane R, Hartert, Tina, Khurana Hershey, Gurjit K, Hogarth, D Kyle, Jackson, Daniel J, Johnson, Christine C, Lemanske, Robert F, Lynch, Susan V, Mendonca, Eneida A, Miller, Rachel L, Naureckas, Edward T, O'Connor, George T, Seroogy, Christine M, White, Steven R, Wood, Robert A, Wright, Anne L, Zoratti, Edward M, Martinez, Fernando D, Nicolae, Dan L, Levin, Albert M, and Gern, James E
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- 2020
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20. Evaluating predictive relationships between wristbands and urine for assessment of personal PAH exposure
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Dixon, Holly M., Bramer, Lisa M., Scott, Richard P., Calero, Lehyla, Holmes, Darrell, Gibson, Elizabeth A., Cavalier, Haleigh M., Rohlman, Diana, Miller, Rachel L., Calafat, Antonia M., Kincl, Laurel, Waters, Katrina M., Herbstman, Julie B., and Anderson, Kim A.
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- 2022
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21. African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans
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Washington, III, Charles, Dapas, Matthew, Biddanda, Arjun, Magnaye, Kevin M., Aneas, Ivy, Helling, Britney A., Szczesny, Brooke, Boorgula, Meher Preethi, Taub, Margaret A., Kenny, Eimear, Mathias, Rasika A., Barnes, Kathleen C., Khurana Hershey, Gurjit K., Kercsmar, Carolyn M., Gereige, Jessica D., Makhija, Melanie, Gruchalla, Rebecca S., Gill, Michelle A., Liu, Andrew H., Rastogi, Deepa, Busse, William, Gergen, Peter J., Visness, Cynthia M., Gold, Diane R., Hartert, Tina, Johnson, Christine C., Lemanske, Jr., Robert F., Martinez, Fernando D., Miller, Rachel L., Ownby, Dennis, Seroogy, Christine M., Wright, Anne L., Zoratti, Edward M., Bacharier, Leonard B., Kattan, Meyer, O’Connor, George T., Wood, Robert A., Nobrega, Marcelo A., Altman, Matthew C., Jackson, Daniel J., Gern, James E., McKennan, Christopher G., and Ober, Carole
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- 2022
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22. Exposure to polycyclic aromatic hydrocarbons during pregnancy and breast tissue composition in adolescent daughters and their mothers: a prospective cohort study
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Kehm, Rebecca D., Walter, E. Jane, Oskar, Sabine, White, Melissa L., Tehranifar, Parisa, Herbstman, Julie B., Perera, Frederica, Lilge, Lothar, Miller, Rachel L., and Terry, Mary Beth
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- 2022
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23. Vishniacozyma victoriae (syn. Cryptococcus victoriae) in the homes of asthmatic and non-asthmatic children in New York City
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Rush, Rachael E., Dannemiller, Karen C., Cochran, Samuel J., Haines, Sarah R., Acosta, Luis, Divjan, Adnan, Rundle, Andrew G., Miller, Rachel L., Perzanowski, Matthew S., Croston, Tara L., and Green, Brett J.
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- 2022
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24. Breast cancer family history and allele-specific DNA methylation in the legacy girls study
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Wu, Hui-Chen, Do, Catherine, Andrulis, Irene L, John, Esther M, Daly, Mary B, Buys, Saundra S, Chung, Wendy K, Knight, Julia A, Bradbury, Angela R, Keegan, Theresa HM, Schwartz, Lisa, Krupska, Izabela, Miller, Rachel L, Santella, Regina M, Tycko, Benjamin, and Terry, Mary Beth
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Biological Sciences ,Genetics ,Prevention ,Genetic Testing ,Breast Cancer ,Human Genome ,Cancer ,2.1 Biological and endogenous factors ,Aetiology ,Adolescent ,Alleles ,Breast Neoplasms ,Child ,CpG Islands ,DNA Methylation ,DNA-Binding Proteins ,Epigenesis ,Genetic ,Estrogen Receptor alpha ,Female ,Genome-Wide Association Study ,Haplotypes ,Humans ,Medical History Taking ,Polymorphism ,Single Nucleotide ,Quantitative Trait Loci ,Breast cancer family history ,DNA methylation ,mQTL ,white blood cells ,childhood and adolescent cohort ,white blood cells ,childhood and adolescent cohort ,Biochemistry and Cell Biology ,Medical Biochemistry and Metabolomics ,Developmental Biology ,Biochemistry and cell biology - Abstract
Family history, a well-established risk factor for breast cancer, can have both genetic and environmental contributions. Shared environment in families as well as epigenetic changes that also may be influenced by shared genetics and environment may also explain familial clustering of cancers. Epigenetic regulation, such as DNA methylation, can change the activity of a DNA segment without a change in the sequence; environmental exposures experienced across the life course can induce such changes. However, genetic-epigenetic interactions, detected as methylation quantitative trait loci (mQTLs; a.k.a. meQTLs) and haplotype-dependent allele-specific methylation (hap-ASM), can also contribute to inter-individual differences in DNA methylation patterns. To identify differentially methylated regions (DMRs) associated with breast cancer susceptibility, we examined differences in white blood cell DNA methylation in 29 candidate genes in 426 girls (ages 6-13 years) from the LEGACY Girls Study, 239 with and 187 without a breast cancer family history (BCFH). We measured methylation by targeted massively parallel bisulfite sequencing (bis-seq) and observed BCFH DMRs in two genes: ESR1 (Δ4.9%, P = 0.003) and SEC16B (Δ3.6%, P = 0.026), each of which has been previously implicated in breast cancer susceptibility and pubertal development. These DMRs showed high inter-individual variability in methylation, suggesting the presence of mQTLs/hap-ASM. Using single nucleotide polymorphisms data in the bis-seq amplicon, we found strong hap-ASM in SEC16B (with allele specific-differences ranging from 42% to 74%). These findings suggest that differential methylation in genes relevant to breast cancer susceptibility may be present early in life, and that inherited genetic factors underlie some of these epigenetic differences.
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- 2018
25. Indoor Environmental Factors May Modify the Response to Mouse Allergen Reduction Among Mouse-Sensitized and Exposed Children with Persistent Asthma
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Sadreameli, S. Christy, Ahmed, Ammara, Curtin-Brosnan, Jean, Perzanowski, Matthew S., Phipatanakul, Wanda, Balcer-Whaley, Susan, Divjan, Adnan, Peng, Roger D., Newman, Michelle, Cunningham, Amparito, Bollinger, Mary E., Wise, Robert A., Miller, Rachel L., and Matsui, Elizabeth C.
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- 2021
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26. Pediatric asthma incidence rates in the United States from 1980 to 2017
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Johnson, Christine C., Havstad, Suzanne L., Ownby, Dennis R., Joseph, Christine L.M., Sitarik, Alexandra R., Biagini Myers, Jocelyn, Gebretsadik, Tebeb, Hartert, Tina V., Khurana Hershey, Gurjit K., Jackson, Daniel J., Lemanske, Robert F., Jr., Martin, Lisa J., Zoratti, Edward M., Visness, Cynthia M., Ryan, Patrick H., Gold, Diane R., Martinez, Fernando D., Miller, Rachel L., Seroogy, Christine M., Wright, Anne L., and Gern, James E.
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- 2021
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27. Development and Outcomes of Returning Polycyclic Aromatic Hydrocarbon Exposure Results in the Washington Heights, NYC Community.
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Riley, Kylie W, Burke, Kimberly, Dixon, Holly, Holmes, Darrell, Calero, Lehyla, Barton, Michael, Miller, Rachel L, Bramer, Lisa M, Waters, Katrina M, Anderson, Kim A, Herbstman, Julie, and Rohlman, Diana
- Abstract
Report-back of research results (RBRR) is becoming standard practice for environmental health research studies. RBRR is thought to increase environmental health literacy (EHL), although standardized measurements are limited. For this study, we developed a report back document on exposure to air pollutants, Polycyclic Aromatic Hydrocarbons, during pregnancy through community engaged research and evaluated whether the report increased EHL. We used focus groups and surveys to gather feedback on the report document from an initial group of study participants (Group 1, n = 22) and then sent the revised report to a larger number of participants (Group 2, n = 168). We conducted focus groups among participants in Group 1 and discussed their suggested changes to the report and how those changes could be implemented. Participants in focus groups demonstrated multiple levels of EHL. While participant engagement critically informed report development, a survey comparing feedback from Group 1 (initial report) and Group 2 (revised report) did not show a significant difference in the ease of reading the report or knowledge gained about air pollutants. We acknowledge that our approach was limited by a lack of EHL tools that assess knowledge and behavior change, and a reliance on quantitative methodologies. Future approaches that merge qualitative and quantitative methodologies to evaluate RBRR and methodologies for assessing RBRR materials and subsequent changes in knowledge, attitudes, and behavior, may be necessary. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Rhinorrhea and watery eyes in infancy and risk of attention‐deficit hyperactivity disorder in school‐age children.
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Perzanowski, Matthew S., Rauh, Virginia, Ramphal, Bruce, Acosta, Luis, Hoepner, Lori, Rundle, Andrew G., Perera, Frederica P., Herbstman, Julie, Miller, Rachel L., and Margolis, Amy E.
- Abstract
Increased parasympathetic nervous system (PNS) activity is associated with attention‐deficit/hyperactivity disorder (ADHD) inattentive symptoms, but not hyperactive‐impulsive symptoms, and may contribute to inattentive subtype etiology. Guided by prior work linking infant rhinorrhea and watery eyes without a cold (RWWC) to PNS dysregulation, we examined associations between infant RWWC and childhood ADHD symptoms in a longitudinal cohort of Black and Latinx children living in the context of economic disadvantage (N = 301 youth: 158 females, 143 males). Infant RWWC predicted higher inattentive (relative risk [RR] 2.16, p <.001) but not hyperactive‐impulsive (RR 1.53, p =.065) ADHD symptoms (DuPaul scale), administered to caregivers at child age 8–14 years. Stratified analyses revealed that these associations were present in females but not males, who were three times more likely to have higher ADHD current total symptoms if they had infant RWWC than if they did not. Additionally, associations between RWWC and inattention symptoms were observed only in females. RWWC may thus serve as a novel risk marker of ADHD inattentive‐type symptoms, especially for females. [ABSTRACT FROM AUTHOR]
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- 2024
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29. Inverse associations of cord blood mitochondrial DNA copy number with childhood adiposity.
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Reddam, Aalekhya, Bloomquist, Tessa R., Covell, Lindsey T., Hu, Heng, Oberfield, Sharon E., Gallagher, Dympna, Miller, Rachel L., Goldsmith, Jeff, Rundle, Andrew G., Baccarelli, Andrea A., Herbstman, Julie B., and Kupsco, Allison
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CORD blood ,MITOCHONDRIAL DNA ,AFRICAN American children ,OBESITY ,ADIPOSE tissues - Abstract
Objective: The objective of this study was to examine associations between umbilical cord mitochondrial DNA copy number (mtDNAcn) and adiposity across childhood. Methods: In a prospective birth cohort of Dominican and African American children from New York City, New York (1998–2006), mtDNAcn was measured in cord blood. Children (N = 336) were evaluated for their height, weight, and bioimpedance at age 5, 7, 9, and 11 years. We used linear mixed‐effects models to assess associations of mtDNAcn tertiles in cord blood with child BMI, BMI z scores, fat mass index, and body fat percentage. Latent class growth models and interactions between mtDNAcn and child age or child age2 were used to assess associations between age and adiposity trajectories. Results: BMI was, on average, 1.5 kg/m2 higher (95% CI: 0.58, 2.5) in individuals with mtDNAcn in the low‐ compared with the middle‐mtDNAcn tertile. Results were similar for BMI z score, fat mass index, and body fat percentage. Moreover, children in the low‐mtDNAcn group had increased odds of being in an "increasing" or "high‐stable" adiposity class. Conclusions: Lower mtDNAcn at birth may predict greater childhood adiposity, highlighting the potential key role of perinatal mitochondrial function in adiposity during development. [ABSTRACT FROM AUTHOR]
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- 2024
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30. Report of prenatal maternal demoralization and material hardship and infant rhinorrhea and watery eyes
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Conrad, Laura A., Rauh, Virginia A., Hoepner, Lori A., Acosta, Luis M., Perera, Frederica P., Rundle, Andrew G., Arteaga-Solis, Emilio, Miller, Rachel L., and Perzanowski, Matthew S.
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- 2020
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31. Trees, tensions, and transactional communities: Problematizing frameworks for energy poverty alleviation in the Rhino Camp refugee settlement, Uganda
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Miller, Rachel L. and Ulfstjerne, Michael A.
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- 2020
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32. Children and Young Adults Who Received Tracheostomies or Were Initiated on Long-Term Ventilation in PICUs*
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Edwards, Jeffrey D, Houtrow, Amy J, Lucas, Adam R, Miller, Rachel L, Keens, Thomas G, Panitch, Howard B, and Dudley, R Adams
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Clinical Research ,Patient Safety ,Pediatric ,Respiratory ,Good Health and Well Being ,Adolescent ,Child ,Child ,Preschool ,Chronic Disease ,Cross-Sectional Studies ,Female ,Healthcare Disparities ,Humans ,Infant ,Intensive Care Units ,Pediatric ,Male ,North America ,Practice Patterns ,Physicians' ,Respiration ,Artificial ,Respiratory Insufficiency ,Retrospective Studies ,Tracheostomy ,Young Adult ,chronic disease ,intensive care units ,pediatric ,respiratory insufficiency ,tracheostomy ,Nursing ,Paediatrics and Reproductive Medicine ,Pediatrics - Abstract
ObjectivesTo characterize patients who received tracheostomies for airway compromise or were initiated on long-term ventilation for chronic respiratory failure in PICUs and to examine variation in the incidence of initiation, patient characteristics, and modalities across sites.DesignRetrospective cross-sectional analysis.SettingsSeventy-three North American PICUs that participated in the Virtual Pediatric Systems, LLC.PatientsPICU patients admitted between 2009 and 2011.InterventionsNone.Measurements and main resultsAmong 115,437 PICU patients, 1.8% received a tracheostomy or were initiated on long-term ventilation; 1,034 received a tracheostomy only, 717 were initiated on invasive ventilation, and 381 were initiated on noninvasive ventilation. Ninety percent had substantial chronic conditions and comorbidities, including more than 50% with moderate or worse cerebral disability upon discharge. Seven percent were initiated after a catastrophic injury/event. Across sites, there was variation in incidence of tracheotomy and initiation of long-term ventilation, ranging from 0% to 4.6%. There also was variation in patient characteristics, time to tracheotomy, number of extubations prior to tracheostomy, and the use of invasive ventilation versus noninvasive ventilation.ConclusionsAlthough the PICU incidence of initiation of tracheostomies and long-term ventilation was relatively uncommon, it suggests that thousands of children and young adults receive these interventions each year in North American PICUs. The majority of them have conditions and comorbidities that impose on-going care needs, beyond those required by artificial airways and long-term ventilation themselves.
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- 2016
33. Trajectory analysis of rhinitis in a birth cohort from lower-income New York City neighborhoods
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Flores, Nina M., primary, Lovinsky-Desir, Stephanie, additional, Divjan, Adnan, additional, Hoepner, Lori A., additional, Zou, Jungang, additional, Miller, Rachel L., additional, Herbstman, Julie B., additional, Perera, Frederica P., additional, Perzanowski, Matthew S., additional, and Chen, Qixuan, additional
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- 2023
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34. The Role of Childhood Asthma in Obesity Development: A Nationwide U.S. Multi-cohort Study
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Stratakis, Nikos, Garcia, Erika, Chandran, Aruna, Hsu, Tingju, Alshawabkeh, Akram, Aris, Izzuddin M., Aschner, Judy L., Breton, Carrie, Burbank, Allison, Camargo, Carlos A., Jr, Carroll, Kecia N., Chen, Zhanghua, Claud, Erika C., Dabelea, Dana, Dunlop, Anne L., Elliott, Amy J., Ferrara, Assiamira, Ganiban, Jody M., Gern, James E., Gold, Diane R, Gower, William A., Hertz-Picciotto, Irva, Karagas, Margaret R., Karr, Catherine J., Lester, Barry, Leve, Leslie D., Litonjua, Augusto A., Ludena, Yunin, McEvoy, Cindy T., Miller, Rachel L., Mueller, Noel T., O’Connor, Thomas G., Oken, Emily, O’Shea, T. Michael, Perera, Frederica, Stanford, Joseph B., Rivera-Spoljaric, Katherine, Rundle, Andrew, Trasande, Leonardo, Wright, Rosalind J., Zhang, Yue, Zhu, Yeyi, Berhane, Kiros, Gilliland, Frank, and Chatzi, Lida
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- 2021
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35. Advances in drug allergy, urticaria, angioedema, and anaphylaxis in 2018
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Miller, Rachel L., Shtessel, Maria, Robinson, Lacey B., and Banerji, Aleena
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- 2019
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36. Environmental medical epigenetics: A review of epigenetically induced medical risks generated from exposures in our air, food, and personal products
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Miller, Rachel L., primary and Oh, Jessica, additional
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- 2021
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37. Contributors
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Abi Khalil, Charbel, primary, Akins, Robert E., additional, Alenghat, T., additional, Allen, Emily G, additional, Altorok, N., additional, Altucci, Lucia, additional, Balcerczyk, Aneta, additional, Barragán, Isabel, additional, Biesiekierska, Marta, additional, Biradar, Vinayak S., additional, Blossom, Sarah J., additional, Chaves, Patricia, additional, Chen, D., additional, Chen, Hong, additional, Chen, Shijia Alexia, additional, Cheng, Baoli, additional, Chun, P., additional, Ciesielski, Oskar, additional, Colon-Diaz, Maricarmen, additional, Cox, O.H., additional, Cozma, Angela, additional, Cui, Xiaolong, additional, Dekker, F.J., additional, Dell’Aversana, Carmela, additional, Demirdizen, Engin, additional, Deng, Jiali, additional, Deobagkar, Deepti D., additional, Dvir-Ginzberg, Mona, additional, Ehnes, Devon, additional, Eissenberg, J.C., additional, Elosegui, Perla M., additional, Fodor, Adriana, additional, Ganesan, A., additional, Giorgio, Cristina, additional, Guo, Mengying, additional, Hall, J.G., additional, Hashimoto-Hill, S., additional, Imam, Mustapha Umar, additional, Ismail, Maznah, additional, Jaramillo, Alexander J., additional, Jennings, M.P., additional, Jin, Peng, additional, Johnson, A.C., additional, Kahaleh, B., additional, Kelly, D.R., additional, Koliada, Alexander, additional, Kolliputi, Narasaiah, additional, Kumar, Ashok, additional, Lee, R.S., additional, Levenson, Anait S., additional, Levy, Shiri, additional, Ligon, C.O., additional, Liguori, Maria, additional, Liu, Ji, additional, Louwies, T., additional, Lu, Qianjin, additional, Luo, Shuaihantian, additional, Lushchak, Oleh, additional, Meerveld, B. Greenwood-Van, additional, Miller, Rachel L., additional, Nagaraja, V., additional, Navada, Shyamala C., additional, Nuzziello, Nicoletta, additional, Oh, Jessica, additional, Oltra, Elisa, additional, Onieva, Juan Luis, additional, Ooi, Der Jiun, additional, Pirola, Luciano, additional, Proschinger, S., additional, Rajpathak, Shriram N., additional, Robinson, Karyn G., additional, Roman, Gabriela, additional, Ruohola-Baker, Hannele, additional, Rusu, Adriana, additional, Sanusi, Kamaldeen Olalekan, additional, Schenk, A., additional, Seib, K.L., additional, Sgueglia, Giulia, additional, Shu, Liqi, additional, Singh, J., additional, Sitar-Tăut, Adela, additional, Soto, Edwin Y., additional, Suharoschi, Ramona, additional, Tajbakhsh, J., additional, Tambaro, Francesco Paolo, additional, Taranda, Julian, additional, Thoutam, Akshaya, additional, Tollefsbol, Trygve O., additional, Trojer, P., additional, Turcan, Sevin, additional, Uthman, Yaaqub Abiodun, additional, Vaiserman, Alexander, additional, Vulturar, Romana, additional, Wang, Huan, additional, Wapenaar, H., additional, Weksberg, R., additional, Xiao, Junjie, additional, Xu, Guanying Bianca, additional, Zeng, Chang, additional, Zhang, Wei, additional, Zhang, Zhou, additional, and Zimmer, P., additional
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- 2021
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38. Cohort Profile: The Mothers and Newborns (MN) Cohort of the Columbia Center for Children's Environmental Health.
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Riley, Kylie W, Guo, Jia, Wang, Shuang, Factor-Litvak, Pam, Miller, Rachel L, Andrews, Howard, Hoepner, Lori A, Margolis, Amy E, Rauh, Virginia, Rundle, Andrew, Perera, Frederica, and Herbstman, Julie B
- Subjects
PREMATURE infants ,IMMUNOGLOBULIN E ,INFANTS ,WHEEZE ,CHILDREN'S health ,WECHSLER Intelligence Scale for Children ,NEWBORN infants - Abstract
The given text describes the Mothers and Newborns (MN) Cohort study conducted by the Columbia Center for Children's Environmental Health. The study focuses on the impact of prenatal and early-life environmental exposures on children's health outcomes, with a specific emphasis on minority populations. The cohort consists of 727 women and their children from Northern Manhattan and the south Bronx in New York City. Data collected includes exposure to environmental pollutants, social risk factors, and health outcomes such as birth outcomes, neurodevelopment, asthma, and obesity. The study aims to contribute to scientific understanding and inform policymakers about the associations between environmental toxicants and health outcomes. The text also includes a table presenting data collected in the study, which can be useful for library patrons conducting research on these specific topics. The study has found associations between prenatal exposure to pollutants and various adverse outcomes in children. Interested researchers can access the de-identified data through the CCCEH's Data Coordinating Center. [Extracted from the article]
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- 2024
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39. PM2.5 Is Insufficient to Explain Personal PAH Exposure.
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Bramer, Lisa M., Dixon, Holly M., Rohlman, Diana, Scott, Richard P., Miller, Rachel L., Kincl, Laurel, Herbstman, Julie B., Waters, Katrina M., and Anderson, Kim A.
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MACHINE learning ,AIR quality indexes ,PARTICULATE matter ,AIR quality ,TOBACCO smoke ,POLYCYCLIC aromatic hydrocarbons ,AIR pollutants - Abstract
To understand how chemical exposure can impact health, researchers need tools that capture the complexities of personal chemical exposure. In practice, fine particulate matter (PM2.5) air quality index (AQI) data from outdoor stationary monitors and Hazard Mapping System (HMS) smoke density data from satellites are often used as proxies for personal chemical exposure, but do not capture total chemical exposure. Silicone wristbands can quantify more individualized exposure data than stationary air monitors or smoke satellites. However, it is not understood how these proxy measurements compare to chemical data measured from wristbands. In this study, participants wore daily wristbands, carried a phone that recorded locations, and answered daily questionnaires for a 7‐day period in multiple seasons. We gathered publicly available daily PM2.5 AQI data and HMS data. We analyzed wristbands for 94 organic chemicals, including 53 polycyclic aromatic hydrocarbons. Wristband chemical detections and concentrations, behavioral variables (e.g., time spent indoors), and environmental conditions (e.g., PM2.5 AQI) significantly differed between seasons. Machine learning models were fit to predict personal chemical exposure using PM2.5 AQI only, HMS only, and a multivariate feature set including PM2.5 AQI, HMS, and other environmental and behavioral information. On average, the multivariate models increased predictive accuracy by approximately 70% compared to either the AQI model or the HMS model for all chemicals modeled. This study provides evidence that PM2.5 AQI data alone or HMS data alone is insufficient to explain personal chemical exposures. Our results identify additional key predictors of personal chemical exposure. Plain Language Summary: Tools are needed to determine how chemical exposures may affect people's health. It is not understood how air quality data from stationary air monitors and smoke density data from satellites align with personal chemical exposure data from silicone wristbands; we present the first study to evaluate this. In this study, people wore wristbands, carried phones to track their locations, and answered questions for a week in different seasons. We also collected fine particulate matter data from outdoor monitors and satellites and tested the wristbands for 94 different chemicals. The results showed that the wristband data, along with other information like where people spent time and the air quality, varied between seasons. We used machine learning models to predict personal chemical exposure using only the data from monitors or satellites, and then using a mix of data from both, along with additional data about the environment and people's behaviors. Models that used a mix of data were much better at predicting exposure compared to using just one type of data. This study tells us that using fine particulate data from monitors or satellites is not enough to understand personal chemical exposure. Key Points: Explaining personal chemical exposures required more than fine particulate matter air quality index (AQI) or hazard mapping system dataModels with variables in addition to fine particulate matter AQI increased predictive accuracy of exposureHeavy wildfire smoke was measured during the study [ABSTRACT FROM AUTHOR]
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- 2024
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40. Supplementary Figure S1 from Socioeconomic Status at Birth and Breast Tissue Composition in Adolescence and Adulthood
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Kehm, Rebecca D., primary, Lilge, Lothar, primary, Walter, E. Jane, primary, White, Melissa, primary, Herbstman, Julie B., primary, Perera, Frederica P., primary, Miller, Rachel L., primary, Terry, Mary Beth, primary, and Tehranifar, Parisa, primary
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- 2023
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41. Data from Socioeconomic Status at Birth and Breast Tissue Composition in Adolescence and Adulthood
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Kehm, Rebecca D., primary, Lilge, Lothar, primary, Walter, E. Jane, primary, White, Melissa, primary, Herbstman, Julie B., primary, Perera, Frederica P., primary, Miller, Rachel L., primary, Terry, Mary Beth, primary, and Tehranifar, Parisa, primary
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- 2023
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42. Supplementary Table S1 from Socioeconomic Status at Birth and Breast Tissue Composition in Adolescence and Adulthood
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Kehm, Rebecca D., primary, Lilge, Lothar, primary, Walter, E. Jane, primary, White, Melissa, primary, Herbstman, Julie B., primary, Perera, Frederica P., primary, Miller, Rachel L., primary, Terry, Mary Beth, primary, and Tehranifar, Parisa, primary
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- 2023
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43. Performance of the Pediatric Asthma Risk Score across Diverse Populations
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Biagini, Jocelyn M., primary, Martin, Lisa J., additional, He, Hua, additional, Bacharier, Leonard B., additional, Gebretsadik, Tebeb, additional, Hartert, Tina V., additional, Jackson, Daniel J., additional, Kim, Haejin, additional, Miller, Rachel L., additional, Rivera-Spoljaric, Katherine, additional, Schauberger, Eric M., additional, Singh, Anne Marie, additional, Visness, Cynthia M., additional, Wegienka, Ganesa, additional, Ownby, Dennis R., additional, Gold, Diane R., additional, Martinez, Fernando D., additional, Johnson, Christine C., additional, Wright, Anne L., additional, Gern, James E., additional, and Khurana Hershey, Gurjit K., additional
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- 2023
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44. Molecular Mechanisms Controlling Immunoglobulin E Responses
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Miller, Rachel L., primary and Rothman, Paul B., additional
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- 2020
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45. Air pollution, urgent asthma medical visits and the modifying effect of neighborhood asthma prevalence
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Lovinsky-Desir, Stephanie, Acosta, Luis M., Rundle, Andrew G., Miller, Rachel L., Goldstein, Inge F., Jacobson, Judith S., Chillrud, Steven N., and Perzanowski, Matthew S.
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- 2019
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46. Secondhand smoke in combination with ambient air pollution exposure is associated with increased CpG methylation and decreased expression of IFN-gamma in T effector cells and Foxp3 in T regulatory cells in children
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Kohli, Arunima, Garcia, Marco A, Miller, Rachel L, Maher, Christina, Humblet, Olivier, Hammond, S, and Nadeau, Kari
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Abstract Background Secondhand smoke (SHS) and ambient air pollution (AAP) exposures have been associated with increased prevalence and severity of asthma and DNA modifications of immune cells. In the current study, we examined the association between SHS and AAP with DNA methylation and expression of interferon-gamma (IFN-γ) and forkhead box protein 3 (Foxp3) in T cell populations. Methods Subjects 7–18 years old were recruited from Fresno (high AAP; n = 62) and Stanford, CA (low AAP; n = 40) and divided into SHS-exposed (Fresno: n = 31, Stanford: n = 6) and non-SHS-exposed (nSHS; Fresno: n = 31, Stanford: n = 34) groups. T cells purified from peripheral blood were assessed for levels of DNA methylation and expression of IFN-γ (in effector T cells) or Foxp3 (in regulatory T cells). Results Analysis showed a significant increase in mean % CpG methylation of IFN-γ and Foxp3 associated with SHS exposure (IFN-γ: FSHS 62.10%, FnSHS 41.29%, p
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- 2012
47. Cord blood versus age 5 mononuclear cell proliferation on IgE and asthma
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Chang, Carolyn, Gauvey-Kern, Kevin, Johnson, Alina, Kelvin, Elizabeth A, Chew, Ginger L, Perera, Frederica, and Miller, Rachel L
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Abstract Background Fetal immune responses following exposure of mothers to allergens during pregnancy may influence the subsequent risk of childhood asthma. However, the association of allergen-induced cord blood mononuclear cell (CBMC) proliferation and cytokine production with later allergic immune responses and asthma has been controversial. Our objective was to compare indoor allergen-induced CBMC with age 5 peripheral blood mononuclear cell (PBMC) proliferation and determine which may be associated with age 5 allergic immune responses and asthma in an inner city cohort. Methods As part of an ongoing cohort study of the Columbia Center for Children's Environmental Health (CCCEH), CBMCs and age 5 PBMCs were cultured with cockroach, mouse, and dust mite protein extracts. CBMC proliferation and cytokine (IL-5 and IFN-γ) responses, and age 5 PBMC proliferation responses, were compared to anti-cockroach, anti-mouse, and anti-dust mite IgE levels, wheeze, cough, eczema and asthma. Results Correlations between CBMC and age 5 PBMC proliferation in response to cockroach, mouse, and dust mite antigens were nonsignificant. Cockroach-, mouse-, and dust mite-induced CBMC proliferation and cytokine responses were not associated with allergen-specific IgE at ages 2, 3, and 5, or with asthma and eczema at age 5. However, after adjusting for potential confounders, age 5 cockroach-induced PBMC proliferation was associated with anti-cockroach IgE, total IgE, and asthma (p < 0.05). Conclusion In contrast to allergen-induced CBMC proliferation, age 5 cockroach-induced PBMC proliferation was associated with age 5 specific and total IgE, and asthma, in an inner-city cohort where cockroach allergens are prevalent and exposure can be high.
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- 2010
48. Socioeconomic Status at Birth and Breast Tissue Composition in Adolescence and Adulthood
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Kehm, Rebecca D., primary, Lilge, Lothar, additional, Walter, E. Jane, additional, White, Melissa, additional, Herbstman, Julie B., additional, Perera, Frederica P., additional, Miller, Rachel L., additional, Terry, Mary Beth, additional, and Tehranifar, Parisa, additional
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- 2023
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49. Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program
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Miller, Rachel L., primary, Schuh, Holly, additional, Chandran, Aruna, additional, Aris, Izzuddin M., additional, Bendixsen, Casper, additional, Blossom, Jeffrey, additional, Breton, Carrie, additional, Camargo, Carlos A., additional, Canino, Glorisa, additional, Carroll, Kecia N., additional, Commodore, Sarah, additional, Cordero, José F., additional, Dabelea, Dana M., additional, Ferrara, Assiamira, additional, Fry, Rebecca C., additional, Ganiban, Jody M., additional, Gern, James E., additional, Gilliland, Frank D., additional, Gold, Diane R., additional, Habre, Rima, additional, Hare, Marion E., additional, Harte, Robyn N., additional, Hartert, Tina, additional, Hasegawa, Kohei, additional, Khurana Hershey, Gurjit K., additional, Jackson, Daniel J., additional, Joseph, Christine, additional, Kerver, Jean M., additional, Kim, Haejin, additional, Litonjua, Augusto A., additional, Marsit, Carmen J., additional, McEvoy, Cindy, additional, Mendonça, Eneida A., additional, Moore, Paul E., additional, Nkoy, Flory L., additional, O’Connor, Thomas G., additional, Oken, Emily, additional, Ownby, Dennis, additional, Perzanowski, Matthew, additional, Rivera-Spoljaric, Katherine, additional, Ryan, Patrick H., additional, Singh, Anne Marie, additional, Stanford, Joseph B., additional, Wright, Rosalind J., additional, Wright, Robert O., additional, Zanobetti, Antonella, additional, Zoratti, Edward, additional, Johnson, Christine C., additional, Smith, P.B., additional, Newby, K.L., additional, Jacobson, L.P., additional, Catellier, D.J., additional, Gershon, R., additional, Cella, D., additional, Alshawabkeh, A., additional, Aschner, J., additional, Merhar, S., additional, Ren, C., additional, Reynolds, A., additional, Keller, R., additional, Pryhuber, G., additional, Duncan, A., additional, Lampland, A., additional, Wadhawan, R., additional, Wagner, C., additional, Hudak, M., additional, Mayock, D., additional, Walshburn, L., additional, Teitelbaum, S.L., additional, Stroustrup, A., additional, Trasande, L., additional, Blair, C., additional, Gatzke-Kopp, L., additional, Swingler, M., additional, Mansbach, J., additional, Spergel, J., additional, Puls, H., additional, Stevenson, M., additional, Bauer, C., additional, Deoni, S., additional, Duarte, C., additional, Dunlop, A., additional, Elliott, A., additional, Croen, L., additional, Bacharier, L., additional, O’Connor, G., additional, Kattan, M., additional, Wood, R., additional, Hershey, G., additional, Ownby, D., additional, Hertz-Picciotto, I., additional, Hipwell, A., additional, Karagas, M., additional, Karr, C., additional, Mason, A., additional, Sathyanarayana, S., additional, Lester, B., additional, Carter, B., additional, Neal, C., additional, Smith, L., additional, Helderman, J., additional, Leve, L., additional, Ganiban, J., additional, Neiderhiser, J., additional, Weiss, S., additional, Zeiger, R., additional, Tepper, R., additional, Lyall, K., additional, Landa, R., additional, Ozonoff, S., additional, Schmidt, R., additional, Dager, S., additional, Schultz, R., additional, Piven, J., additional, Volk, H., additional, Vaidya, R., additional, Obeid, R., additional, Rollins, C., additional, Bear, K., additional, Pastyrnak, S., additional, Lenski, M., additional, Msall, M., additional, Frazier, J., additional, Washburn, L., additional, Montgomery, A., additional, Barone, C., additional, McKane, P., additional, Paneth, N., additional, Elliott, M., additional, Herbstman, J., additional, Schantz, S., additional, Porucznik, C., additional, Silver, R., additional, Conradt, E., additional, Bosquet-Enlow, M., additional, Huddleston, K., additional, Bush, N., additional, Nguyen, R., additional, O'Connor, T., additional, and Samuels-Kalow, M., additional
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- 2023
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50. Distribution and Determinants of Mouse Allergen Exposure in Low-Income New York City Apartments
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Chew, Ginger L., Perzanowski, Matthew S., Miller, Rachel L., Correa, Juan C., Hoepner, Lori A., Jusino, Carlos M., Becker, Mark G., and Kinney, Patrick L.
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- 2003
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