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2. Contemporary Training in American Critical Care Cardiology: Minnesota Critical Care Cardiology Education Summit: JACC Scientific Expert Panel

Author

Elliott, Andrea M., Bartos, Jason A., Barnett, Christopher F., Miller, P. Elliott, Roswell, Robert O., Alviar, Carlos, Bennett, Courtney, Berg, David D., Bohula, Erin A., Chonde, Meshe, Dahiya, Garima, Fleitman, Jessica, Gage, Ann, Hansra, Barinder S., Higgins, Andrew, Hollenberg, Steven M., Horowitz, James M., Jentzer, Jacob C., Katz, Jason N., Karpenshif, Yoav, Lee, Ran, Menon, Venu, Metkus, Thomas S., Mukundan, Srini, Rhinehart, Zachary J., Senman, Balimkiz, Senussi, Mourad, Solomon, Michael A., Vallabhajosyula, Saraschandra, and Dudzinski, David M.

Published
2024
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3. Current practices in the management of temporary mechanical circulatory support: A survey of CICU directors in North America

Author

Balgobind, Amrita, Pierce, Matthew, Alviar, Carlos, Barnett, Christopher, Barsness, Gregory, Chaudhry, Sunit-preet, Chonde, Meshe, Cooper, Howard, Daniels, Lori, Gidwani, Umesh, Fordyce, Christopher, Goldfarb, Michael, Katz, Jason N., Kontos, Michael, Kwon, Younghoon, Liebner, Evan, Liu, Shuangbo, Miller, P. Elliott, Newby, L.K., O'Brien, Connor, Papolos, Alexander, Pisani, Barbara, Potter, Brian, Proudfoot, Alastair, Roswell, Robert O., Sinha, Shashank S., Smith, Timothy D., Thompson, Andrea D., van Diepen, Sean, Zakaria, Sammy, Morrow, David, and Villela, Miguel Alvarez

Published
2024
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7. Complex Heart–Lung Ventilator Emergencies in the CICU

Author

Lopez, Mireia Padilla, Applefeld, Willard, Miller, P. Elliott, Elliott, Andrea, Bennett, Courtney, Lee, Burton, Barnett, Christopher, Solomon, Michael A., Corradi, Francesco, Sionis, Alessandro, Mireles-Cabodevila, Eduardo, Tavazzi, Guido, and Alviar, Carlos L.

Published
2024
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8. Early Serial Assessment of Aggregate Vasoactive Support and Mortality in Cardiogenic Shock: Insights From the Critical Care Cardiology Trials Network Registry

Author

Patel, Siddharth M., Berg, David D., Bohula, Erin A., Baird-Zars, Vivian M., Barsness, Gregory W., Chaudhry, Sunit-Preet, Chonde, Meshe D., Cooper, Howard A., Ginder, Curtis, Jentzer, Jacob C., Kontos, Michael C., Miller, P. Elliott, Newby, L. Kristin, O’Brien, Connor G., Park, Jeong-Gun, Pierce, Matthew J., Pisani, Barbara A., Potter, Brian J., Shah, Kevin S., Teuteberg, Jeffrey J., Katz, Jason N., van Diepen, Sean, and Morrow, David A.

Published
2024
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11. Pulmonary Artery Catheter Use and Mortality in the Cardiac Intensive Care Unit

Author

Kadosh, Bernard S., Berg, David D., Bohula, Erin A., Park, Jeong-Gun, Baird-Zars, Vivian M., Alviar, Carlos, Alzate, James, Barnett, Christopher F., Barsness, Gregory W., Burke, James, Chaudhry, Sunit-Preet, Daniels, Lori B., DeFilippis, Andrew, Delicce, Anthony, Fordyce, Christopher B., Ghafghazi, Shahab, Gidwani, Umesh, Goldfarb, Michael, Katz, Jason N., Keeley, Ellen C., Kenigsberg, Benjamin, Kontos, Michael C., Lawler, Patrick R., Leibner, Evan, Menon, Venu, Metkus, Thomas S., Miller, P. Elliott, O’Brien, Connor G., Papolos, Alexander I., Prasad, Rajnish, Shah, Kevin S., Sinha, Shashank S., Snell, R. Jeffrey, So, Derek, Solomon, Michael A., Ternus, Bradley W., Teuteberg, Jeffrey J., Toole, Joseph, van Diepen, Sean, Morrow, David A., and Roswell, Robert O.

Published
2023
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13. Presentation and Outcomes of Patients With Preoperative Critical Illness Undergoing Cardiac Surgery

Author

Metkus, Thomas S., Alviar, Carlos L., Baird-Zars, Vivian M., Barsness, Gregory W., Berg, David D., Bohula, Erin A., Burke, James A., Fordyce, Christopher B., Guo, Jianping, Katz, Jason N., Keeley, Ellen C., Menon, Venu, Miller, P. Elliott, O'Brien, Connor G., Sinha, Shashank S., So, Derek, Ternus, Bradley W., Vadhar, Sagar, van Diepen, Sean, and Morrow, David A.

Published
2023
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18. Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials

Author

Ahmad, Tariq, Miller, P Elliott, McCullough, Megan, Desai, Nihar R, Riello, Ralph, Psotka, Mitchell, Böhm, Michael, Allen, Larry A, Teerlink, John R, Rosano, Giuseppe MC, and Lindenfeld, Joann

Subjects
Heart Disease, Clinical Trials and Supportive Activities, Cardiovascular, Clinical Research, Cardiotonic Agents, Chronic Disease, Clinical Trials as Topic, Exercise Tolerance, Heart Failure, Hemodynamics, Humans, Mortality, Myocardial Contraction, Quality of Life, Stroke Volume, Treatment Failure, Chronic heart failure, Inotropes, Clinical trials, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
Abstract

Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. However, they do not address the symptoms of heart failure that result from reductions in cardiac output and reserve. Over the last few decades, numerous attempts have been made to develop and test positive cardiac inotropes that improve cardiac haemodynamics. However, definitive clinical trials have failed to show a survival benefit. As a result, no positive inotrope is currently approved for long-term use in heart failure. The focus of this state-of-the-art review is to revisit prior clinical trials and to understand the causes for their findings. Using the learnings from those experiences, we propose a framework for future trials of such agents that maximizes their potential for success. This includes enriching the trials with patients who are most likely to derive benefit, using biomarkers and imaging in trial design and execution, evaluating efficacy based on a wider range of intermediate phenotypes, and collecting detailed data on functional status and quality of life. With a rapidly growing population of patients with advanced heart failure, the epidemiologic insignificance of heart transplantation as a therapeutic intervention, and both the cost and morbidity associated with ventricular assist devices, there is an enormous potential for positive inotropic therapies to impact the outcomes that matter most to patients.

Published
2019

20. Tracheostomy in Patients with Acute Myocardial Infarction and Respiratory Failure.

Author

Grammatico, Megan, Banna, Soumya, Shahu, Andi, Gastanadui, Maria Gabriela, Jimenez, Jose Victor, Heck, Cory, Arias-Olson, Abner, Thomas, Alexander, Ali, Tariq, and Miller, P. Elliott

Subjects
PLATELET aggregation inhibitors, HOSPITAL mortality, TRACHEOTOMY, RESPIRATORY insufficiency, ARTIFICIAL respiration
Abstract

Objective: Patients with acute myocardial infarction (AMI) complicated by respiratory failure require antiplatelet regimens which often cannot be stopped and may increase bleeding from tracheostomy. However, there is limited available data on both the proportion of patients undergoing tracheostomy and the impact on antiplatelet regimens on outcomes. Methods: Utilizing the Vizient® Clinical Data Base, we identified patients ≥18 years admitted from 2015 to 2019 with a primary diagnosis of AMI and requiring invasive mechanical ventilation (IMV). We assessed for the incidence of patients undergoing tracheostomy, outcomes stratified by the timing of tracheostomy (≤10 vs >10 days), and the association between dual antiplatelet therapy (DAPT) use and in-hospital mortality. Results: We identified 26 435 patients presenting with AMI requiring IMV. The mean (SD) age was 66.8 (12.3) years and 33.4% were women. The incidence of tracheostomy was 6.0% (n = 1573), and the median IMV time to tracheostomy was 12 days, 55.6% of which underwent percutaneous and 44.4% underwent open tracheostomy. Over 90% (n = 1424) underwent tracheostomy (>10 days) and had a similar mortality when compared to early (≤10 days) tracheostomy (22.5% vs 22.8%, P = 0.94). On the day of tracheostomy, only 24.7% were given DAPT, which was associated with a lower mortality than those not on DAPT (17.4% vs 23.7%, P = 0.01). After multivariable adjustment, DAPT use on the day of tracheostomy remained associated with lower in-hospital mortality (odds ratio 0.68; 95% confidence interval: 0.49-0.94, P = 0.02). Tracheostomy complications were not different between groups (P > 0.05), but more patients in the DAPT group required post-tracheostomy blood transfusions (5.6% vs 2.7%, P = 0.01). Conclusion: Approximately 1 in 20 intubated AMI patients requires tracheostomy. The lack of DAPT interruption on the day of tracheostomy but not the timing of tracheostomy was associated with a lower in-hospital mortality. Our results suggest that DAPT should not be a barrier to tracheostomy for patients with AMI. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Epidemiology of cardiogenic shock using the Shock Academic Research Consortium (SHARC) consensus definitions.

Author

Berg, David D, Bohula, Erin A, Patel, Siddharth M, Alfonso, Carlos E, Alviar, Carlos L, Baird-Zars, Vivian M, Barnett, Christopher F, Barsness, Gregory W, Bennett, Courtney E, Chaudhry, Sunit-Preet, Fordyce, Christopher B, Ghafghazi, Shahab, Gidwani, Umesh K, Goldfarb, Michael J, Katz, Jason N, Menon, Venu, Miller, P Elliott, Newby, L Kristin, Papolos, Alexander I, and Park, Jeong-Gun

Published
2024
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23. The Impact of Depression on Outcomes in Patients With Heart Failure and Reduced Ejection Fraction Treated in the GUIDE-IT Trial

Author

CHOUAIRI, FOUAD, FUERY, MICHAEL A., MULLAN, CLANCY W., CARABALLO, CESAR, SEN, SOUNOK, MAULION, CHRISTOPHER, WILKINSON, SAMUEL T., SURTI, TORAL, MCCULLOUGH, MEGAN, MILLER, P. ELLIOTT, PACOR, JUSTIN, LEIFER, ERIC S., FELKER, G. MICHAEL, VELAZQUEZ, ERIC J., FIUZAT, MONA, O'CONNOR, CHRISTOPHER M., JANUZZI, JAMES L, DESAI, NIHAR R., and AHMAD, TARIQ

Published
2021
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25. Intercountry Differences in Guideline-Directed Medical Therapy and Outcomes Among Patients With Heart Failure

Author

Fuery, Michael A., Chouairi, Fouad, Januzzi, James L., Moe, Gordon W., Caraballo, Cesar, McCullough, Megan, Miller, P. Elliott, Reinhardt, Samuel W., Clark, Katherine, Oseran, Andrew, Milner, Aidan, Pacor, Justin, Kahn, Peter A., Singh, Avinainder, Ravindra, Neal, Guha, Avirup, Vadlamani, Lina, Kulkarni, Neeti S., Fiuzat, Mona, Felker, G. Michael, O’Connor, Christopher M., Ahmad, Tariq, Ezekowitz, Justin, and Desai, Nihar R.

Published
2021
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37. Extra-coronary calcification (aortic valve calcification, mitral annular calcification, aortic valve ring calcification and thoracic aortic calcification) in HIV seropositive and seronegative men: Multicenter AIDS Cohort Study

Author

Rezaeian, Panteha, Miller, P Elliott, Haberlen, Sabina A, Razipour, Aryabod, Bahrami, Hossein, Castillo, Romeo, Witt, Mallory D, Kingsley, Lawrence, Palella, Frank J, Nakanishi, Rine, Matsumoto, Suguru, Alani, Anas, Jacobson, Lisa P, Post, Wendy S, and Budoff, Matthew J

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, HIV/AIDS, Clinical Research, Infectious Diseases, Cardiovascular, Heart Disease - Coronary Heart Disease, Heart Disease, Infection, Good Health and Well Being, Adult, Aged, Aorta, Thoracic, Aortic Diseases, Aortic Valve, Aortography, Biomarkers, Calcinosis, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Coronary Vessels, HIV Infections, HIV Seronegativity, HIV Seropositivity, Heart Valve Diseases, Humans, Inflammation Mediators, Logistic Models, Male, Middle Aged, Mitral Valve, Multidetector Computed Tomography, Multivariate Analysis, Odds Ratio, Plaque, Atherosclerotic, Prevalence, Prognosis, Prospective Studies, Risk Factors, United States, Vascular Calcification, Extra-coronary calcification, HIV, Coronary plaque morphology, Inflammatory biomarkers, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences, Applied computing
Abstract

IntroductionPrevious studies have demonstrated an association between HIV infection and coronary artery disease (CAD); little is known about potential associations between HIV infection and extra-coronary calcification (ECC).MethodsWe analyzed 621 HIV infected (HIV+) and 384 HIV uninfected (HIV-) men from the Multicenter AIDS Cohort Study who underwent non-contrast computed tomography (CT) from 2010-2013. Agatston scores were calculated for mitral annular calcification (MAC), aortic valve calcification (AVC), aortic valve ring calcification (AVRC), and thoracic aortic calcification (TAC). The associations between HIV infection and the presence of each type of ECC (score > 0) were evaluated by multivariable logistic regression. We also evaluated the association of ECC with inflammatory biomarker levels and coronary plaque morphology.ResultsAmong HIV+ and HIV- men, the age-standardized prevalences were 15% for TAC (HIV+ 14%/HIV- 16%), 10% for AVC (HIV+ 11%/HIV- 8%), 24% for AVRC (HIV+ 23% HIV- 24%), and 5% for MAC (HIV+ 7%/HIV- 3%). After adjustment, HIV+ men had 3-fold greater odds of MAC compared to HIV- men (OR = 3.2, 95% CI: 1.5-6.7), and almost twice the odds of AVC (1.8, 1.1-2.9). HIV serostatus was not associated with TAC or AVRC. AVRC was associated with higher Il-6 and sCD163 levels. TAC was associated with higher ICAM-1, TNF-α RII, and Il-6 levels. AVC and AVRC calcification were associated with presence of non-calcified plaque in HIV+ but not HIV- men.ConclusionHIV infection is an independent predictor of MAC and AVC. Whether these calcifications predict mortality in HIV+ patients deserves further investigation.

Published
2016

38. Brief Report

Author

Miller, P Elliott, Haberlen, Sabina A, Brown, Todd T, Margolick, Joseph B, DiDonato, Joseph A, Hazen, Stanley L, Witt, Mallory D, Kingsley, Lawrence A, Palella, Frank J, Budoff, Matthew, Jacobson, Lisa P, Post, Wendy S, and Sears, Cynthia L

Subjects
HIV/AIDS, Prevention, Clinical Research, Nutrition, Atherosclerosis, Heart Disease - Coronary Heart Disease, Heart Disease, Cardiovascular, Good Health and Well Being, Coronary Stenosis, Gastrointestinal Microbiome, HIV Infections, HIV Seroprevalence, Humans, Male, Methylamines, Middle Aged, Prospective Studies, HIV, trimethylamine-N-oxide, coronary artery disease, Clinical Sciences, Public Health and Health Services, Virology
Abstract

Recent evidence has shown a complex relationship between the gut microbiota, dietary nutrients, and cardiovascular disease (CVD). Trimethylamine-N-oxide (TMAO) production, initiated by the microbiota, has been associated with CVD events. We sought to test if this association exists in HIV-infected persons. After adjusting for aspirin use and CVD risk factors, HIV-infected men were more likely to have coronary stenosis in the second and third TMAO quartiles compared with the first quartile, but did not differ significantly in the fourth quartile. We found an inverted U-shaped association between TMAO levels and the presence of coronary artery stenosis among HIV-infected men.

Published
2016

42. HIV and coronary arterial remodeling from the Multicenter AIDS Cohort Study (MACS)

Author

Miller, P Elliott, Haberlen, Sabina A, Metkus, Thomas, Rezaeian, Panteha, Palella, Frank, Kingsley, Lawrence A, Witt, Mallory D, George, Richard T, Jacobson, Lisa P, Brown, Todd T, Budoff, Matthew, and Post, Wendy S

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Cardiovascular, HIV/AIDS, Heart Disease - Coronary Heart Disease, Infectious Diseases, Clinical Research, Atherosclerosis, Heart Disease, Prevention, Aging, Infection, Acquired Immunodeficiency Syndrome, Adult, Aged, CD4-Positive T-Lymphocytes, Cholesterol, Cohort Studies, Coronary Angiography, Coronary Stenosis, Coronary Vessels, HIV Infections, Humans, Male, Middle Aged, Multivariate Analysis, Myocardial Infarction, Odds Ratio, Plaque, Atherosclerotic, Risk Factors, Systole, Coronary disease, Imaging, Epidemiology, AIDS, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivePositive remodeling (PR), a coronary artery characteristic associated with risk for myocardial infarction (MI), may be more prevalent in HIV-infected (HIV+) people. We evaluated the prevalence of PR using coronary CT angiography (CCTA) in HIV+ and HIV-uninfected (HIV-) men.MethodsMen enrolled in the Multicenter AIDS Cohort Study underwent CCTA if they were 40-70 years, had normal kidney function and no history of coronary revascularization. Multivariable logistic regression models were used to estimate the odds ratio (OR) of PR by HIV serostatus, adjusting for demographics and coronary artery disease (CAD) risk factors. Analysis of PR among atherosclerotic segments further adjusted for plaque type and stenosis.ResultsThe prevalence of PR was 8.4% versus 12.1% (p = 0.10) for HIV- and HIV + men, respectively. After demographic adjustment, HIV + men had twice the odds of PR [OR 2.01(95% CI 1.20-3.38)], which persisted after CAD risk factor adjustment [1.76(1.00-3.10)]. Higher systolic blood pressure, total cholesterol, diabetes medication use, older age, segment number with plaque present, mixed and non-calcified plaque, and stenosis>50%, were associated with increased odds of PR, while higher HDL cholesterol, higher nadir CD4 count, and black race were associated with lower PR odds. Among atherosclerotic segments, the association between HIV infection and PR persisted, but was not statistically significantly.ConclusionHIV+ men have more positively remodeled arterial segments, which may be due to more coronary segments with atherosclerosis or HIV-related immunosuppression. Further studies are needed to evaluate whether PR contributes to higher rates of MI in HIV+ individuals.

Published
2015

45. Comparison of Racial Differences in Plaque Composition and Stenosis Between HIV-Positive and HIV-Negative Men from the Multicenter AIDS Cohort Study

Author

Miller, P Elliott, Budoff, Matthew, Zikusoka, Michelle, Li, Xiuhong, Palella, Frank, Kingsley, Lawrence A, Witt, Mallory D, Sharrett, A Richey, Jacobson, Lisa P, and Post, Wendy S

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Behavioral and Social Science, Heart Disease - Coronary Heart Disease, Clinical Research, Biomedical Imaging, Cardiovascular, Atherosclerosis, HIV/AIDS, Heart Disease, Aged, Calcinosis, Coronary Angiography, Coronary Artery Disease, Cross-Sectional Studies, HIV, HIV Seronegativity, HIV Seropositivity, Humans, Male, Middle Aged, Prevalence, Prognosis, Racial Groups, Retrospective Studies, Risk Factors, Tomography, X-Ray Computed, United States, Continental Population Groups, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

Previous studies demonstrated that blacks have less coronary artery calcification (CAC) than whites. We evaluated racial differences in plaque composition and stenosis in the Multicenter AIDS Cohort Study. HIV-positive and HIV-negative men underwent noncontrast cardiac computed tomography (CT) if they were aged 40 to 70 years, weighed 50% on CTA. The association of presence and extent of plaque with race was determined after adjustment for HIV serostatus, cardiovascular risk factors, and measures of socioeconomic status. The prevalences of any plaque on CTA and noncalcified plaque were not different between black and white men; however, black men had lower prevalences of CAC (prevalence ratio [PR] 0.79, p = 0.01), calcified plaque (PR 0.69, p = 0.002), and stenosis >50% (PR 0.59, p = 0.009). There were no associations between black race and extent of plaque in fully adjusted models. Using log-linear regression, black race was associated with a lower extent of any plaque on CTA in HIV-positive men (estimate = -0.24, p = 0.051) but not in HIV-negative men (0.12, p = 0.50, HIV interaction p = 0.005). In conclusion, a lower prevalence of CAC in black compared with white men appears to reflect less calcification of plaque and stenosis rather than a lower overall prevalence of plaque.

Published
2014

46. Need for a Cardiogenic Shock Team Collaborative--Promoting a Team-Based Model of Care to Improve Outcomes and Identify Best Practices.

Author

Senman, Balimkiz, Jentzer, Jacob C., Barnett, Christopher F., Bartos, Jason A., Berg, David D., Chih, Sharon, Drakos, Stavros G., Dudzinski, David M., Elliott, Andrea, Gage, Ann, Horowitz, James M., Miller, P. Elliott, Sinha, Shashank S., Tehrani, Behnam N., Yuriditsky, Eugene, Vallabhajosyula, Saraschandra, and Katz, Jason N.

Published
2024
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47. Development and validation of a novel score to predict brain death after out-of-hospital cardiac arrest

Author

Kitlen, Eva, primary, Kim, Noah, additional, Rubenstein, Alexandra, additional, Keenan, Caitlyn, additional, Garcia, Gabriella, additional, Khosla, Akhil, additional, Johnson, Jennifer, additional, Miller, P. Elliott, additional, Wira, Charles, additional, Greer, David, additional, Gilmore, Emily J., additional, and Beekman, Rachel, additional

Published
2023
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50. Prognostic significance of haemodynamic parameters in patients with cardiogenic shock

Author

Berg, David D, primary, Kaur, Gurleen, additional, Bohula, Erin A, additional, Baird-Zars, Vivian M, additional, Alviar, Carlos L, additional, Barnett, Christopher F, additional, Barsness, Gregory W, additional, Burke, James A, additional, Chaudhry, Sunit-Preet, additional, Chonde, Meshe, additional, Cooper, Howard A, additional, Daniels, Lori B, additional, Dodson, Mark W, additional, Gerber, Daniel A, additional, Ghafghazi, Shahab, additional, Gidwani, Umesh K, additional, Goldfarb, Michael J, additional, Guo, Jianping, additional, Hillerson, Dustin, additional, Kenigsberg, Benjamin B, additional, Kochar, Ajar, additional, Kontos, Michael C, additional, Kwon, Younghoon, additional, Lopes, Mathew S, additional, Loriaux, Daniel B, additional, Miller, P Elliott, additional, O’Brien, Connor G, additional, Papolos, Alexander I, additional, Patel, Siddharth M, additional, Pisani, Barbara A, additional, Potter, Brian J, additional, Prasad, Rajnish, additional, Rowsell, Robert O, additional, Shah, Kevin S, additional, Sinha, Shashank S, additional, Smith, Timothy D, additional, Solomon, Michael A, additional, Teuteberg, Jeffrey J, additional, Thompson, Andrea D, additional, Zakaria, Sammy, additional, Katz, Jason N, additional, van Diepen, Sean, additional, and Morrow, David A, additional

Published
2023
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