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2. Combined Computed Tomography Angiography-Computed Tomography Perfusion in the Identification and Prognostic Assessment of Myocardial Bridging from the CORE320 Study: 5-Year Follow-Up

Author

Gannon, Michael P., Cerci, Rodrigo J., Valdiviezo, Carolina, Ostovaneh, Mohammad R., Vavere, Andrea L., de Vasconcellos, Henrique Doria, Matheson, Matthew B., Cox, Christopher, Miller, Julie M., di Carli, Marcelo, Arbab-Zadeh, Armin, George, Richard T., Lima, João A.C., and Chen, Marcus Y.

Published
2023
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4. Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease — Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study

Author

Dewey, Marc, Rochitte, Carlos E., Ostovaneh, Mohammad R., Chen, Marcus Y., George, Richard T., Niinuma, Hiroyuki, Kitagawa, Kakuya, Laham, Roger, Kofoed, Klaus, Nomura, Cesar, Sakuma, Hajime, Yoshioka, Kunihiro, Mehra, Vishal C., Jinzaki, Masahiro, Kuribayashi, Sachio, Laule, Michael, Paul, Narinder, Scholte, Arthur J., Cerci, Rodrigo, Hoe, John, Tan, Swee Yaw, Rybicki, Frank J., Matheson, Matthew B., Vavere, Andrea L., Arai, Andrew E., Miller, Julie M., Cox, Christopher, Brinker, Jeffrey, Clouse, Melvin E., Di Carli, Marcelo, Lima, João A.C., and Arbab-Zadeh, Armin

Published
2021
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6. Comparative effectiveness of coronary artery stenosis and atherosclerotic plaque burden assessment for predicting 30-day revascularization and 2-year major adverse cardiac events

Author

Kishi, Satoru, Magalhães, Tiago A., Cerci, Rodrigo J., Zimmermann, Elke, Matheson, Matthew B., Vavere, Andrea, Tanami, Yutaka, Kitslaar, Pieter H., George, Richard T., Brinker, Jeffrey, Miller, Julie M., Clouse, Melvin E., Lemos, Pedro A., Niinuma, Hiroyuki, Reiber, Johan H. C., Kofoed, Klaus F., Rochitte, Carlos E., Rybicki, Frank J., Di Carli, Marcelo F., Cox, Christopher, Lima, Joao A. C., and Arbab-Zadeh, Armin

Published
2020
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11. Total coronary atherosclerotic plaque burden assessment by CT angiography for detecting obstructive coronary artery disease associated with myocardial perfusion abnormalities

Author

Kishi, Satoru, Magalhães, Tiago A., Cerci, Rodrigo J., Matheson, Matthew B., Vavere, Andrea, Tanami, Yutaka, Kitslaar, Pieter H., George, Richard T., Brinker, Jeffrey, Miller, Julie M., Clouse, Melvin E., Lemos, Pedro A., Niinuma, Hiroyuki, Reiber, Johan H.C., Rochitte, Carlos E., Rybicki, Frank J., Di Carli, Marcelo F., Cox, Christopher, Lima, Joao A.C., and Arbab-Zadeh, Armin

Published
2016
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12. Incremental diagnostic accuracy of computed tomography myocardial perfusion imaging over coronary angiography stratified by pre-test probability of coronary artery disease and severity of coronary artery calcification: The CORE320 study

Author

Sharma, Ravi K., Arbab-Zadeh, Armin, Kishi, Satoru, Chen, Marcus Y., Magalhães, Tiago A., George, Richard T., Dewey, Marc, Rybicki, Frank J., Kofoed, Klaus F., de Roos, Albert, Tan, Swee Yaw, Matheson, Matthew, Vavere, Andrea, Cox, Christopher, Clouse, Melvin E., Miller, Julie M., Brinker, Jeffery A., Arai, Andrew E., Di Carli, Marcelo F., Rochitte, Carlos E., and Lima, Joao A.C.

Published
2015
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14. Combined coronary angiography and myocardial perfusion by computed tomography in the identification of flow-limiting stenosis – The CORE320 study: An integrated analysis of CT coronary angiography and myocardial perfusion

Author

Magalhães, Tiago A., Kishi, Satoru, George, Richard T., Arbab-Zadeh, Armin, Vavere, Andrea L., Cox, Christopher, Matheson, Matthew B., Miller, Julie M., Brinker, Jeffrey, Di Carli, Marcelo, Rybicki, Frank J., Rochitte, Carlos E., Clouse, Melvin E., and Lima, João A.C.

Published
2015
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15. Accuracy of multidetector computed tomography for detection of coronary artery stenosis in acute coronary syndrome compared with stable coronary disease: A CORE64 multicenter trial substudy

Author

Sara, Leonardo, Rochitte, Carlos E., Lemos, Pedro A., Niinuma, Hiroyuki, Dewey, Marc, Shapiro, Edward P., Gottlieb, Ilan, Mansur, Antônio P., Nicolau, José C., Lardo, Albert C., Azevedo, Clerio F., Kalil-Filho, Roberto, Vavere, Andrea L., Cohn, Silvia, Cox, Christopher, Brinker, Jeffrey, Miller, Julie M., and Lima, João A.C.

Published
2014
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17. Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention: The PACIFY Randomized Clinical Trial (Platelet Aggregation With Ticagrelor Inhibition and Fentanyl)

Author

McEvoy, John W., Ibrahim, Khalil, Kickler, Thomas S., Clarke, William A., Hasan, Rani K., Czarny, Matthew J., Keramati, Ali R., Goli, Rakesh R., Gratton, Travis P., Brinker, Jeffrey A., Chacko, Matthews, Hwang, Chao-Wei, Johnston, Peter V., Miller, Julie M., Trost, Jeffrey C., Herzog, William R., Blumenthal, Roger S., Thiemann, David R., Resar, Jon R., and Schulman, Steven P.

Published
2018
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19. Impact of Teaching 21st Century Skills on Student Perceptions of Achievement

Author

Miller, Julie M. and Miller, Julie M.

Abstract

As student evaluations of achievement continue to be validated by test performance and quantitative data results, the gap between how students view their achievement in all aspects of their school career continues to lack the instruction of 21st century skills. This study was conducted over a four week period of time in a rural school classroom of 26 third grade students and one teacher-researcher. The study's focus was to determine if the direct teaching of 21st century skills would have an impact on what third graders perceived as achievement. The skills taught were creativity, communication, self-management, problem solving, and critical thinking. To begin the study, the students were asked to explain their understanding of what achievement meant to them. The results indicated a strong connection between grades and report cards as an indicator of achievement in school. The students also participated in a performance task in math within the first week of the study. They documented in their journals and achievement checklists how they showed creativity, stayed organized, managed their time, showed fairness, took turns speaking, and solved problems. During the second through fourth week of the study, the students were taught the 21st century skills, participated in morning meetings, solved performance tasks, and looked for achievement in every area of their school day. The field notes collected, journal entries written, achievement checklists completed, and performance assessments all demonstrated a change in the students' knowledge of achievement. Students shared their ideas during the fourth week through their journal entries and a post-anchor chart. The results indicated a connection to many forms of achievement not considered a part of quantitative data. Students began identifying achievement through quality relationships, communication, creativity within their work, situations of failure, solving problems different ways, listening with empathy, and critically t

Published
2022

20. Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study

Author

Vavere, Andrea L., Simon, Gregory G., George, Richard T., Rochitte, Carlos E., Arai, Andrew E., Miller, Julie M., Di Carli, Marcello, Zadeh, Armin A., Dewey, Marc, Niinuma, Hiroyuki, Laham, Roger, Rybicki, Frank J., Schuijf, Joanne D., Paul, Narinder, Hoe, John, Kuribyashi, Sachio, Sakuma, Hajime, Nomura, Cesar, Yaw, Tan Swee, Kofoed, Klaus F., Yoshioka, Kunihiro, Clouse, Melvin E., Brinker, Jeffrey, Cox, Christopher, and Lima, Joao A.C.

Published
2011
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25. Effect of a Hospital and Postdischarge Quality Improvement Intervention on Clinical Outcomes and Quality of Care for Patients With Heart Failure With Reduced Ejection Fraction

Author

DeVore, Adam D., primary, Granger, Bradi B., additional, Fonarow, Gregg C., additional, Al-Khalidi, Hussein R., additional, Albert, Nancy M., additional, Lewis, Eldrin F., additional, Butler, Javed, additional, Piña, Ileana L., additional, Allen, Larry A., additional, Yancy, Clyde W., additional, Cooper, Lauren B., additional, Felker, G. Michael, additional, Kaltenbach, Lisa A., additional, McRae, A. Thomas, additional, Lanfear, David E., additional, Harrison, Robert W., additional, Disch, Maghee, additional, Ariely, Dan, additional, Miller, Julie M., additional, Granger, Christopher B., additional, and Hernandez, Adrian F., additional

Published
2021
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26. Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease — Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study:Combined CTA/CTP for Long-Term Patient Outcome

Author

Dewey, Marc, Rochitte, Carlos E., Ostovaneh, Mohammad R., Chen, Marcus Y., George, Richard T., Niinuma, Hiroyuki, Kitagawa, Kakuya, Laham, Roger, Kofoed, Klaus, Nomura, Cesar, Sakuma, Hajime, Yoshioka, Kunihiro, Mehra, Vishal C., Jinzaki, Masahiro, Kuribayashi, Sachio, Laule, Michael, Paul, Narinder, Scholte, Arthur J., Cerci, Rodrigo, Hoe, John, Tan, Swee Yaw, Rybicki, Frank J., Matheson, Matthew B., Vavere, Andrea L., Arai, Andrew E., Miller, Julie M., Cox, Christopher, Brinker, Jeffrey, Clouse, Melvin E., Di Carli, Marcelo, Lima, João A.C., Arbab-Zadeh, Armin, Dewey, Marc, Rochitte, Carlos E., Ostovaneh, Mohammad R., Chen, Marcus Y., George, Richard T., Niinuma, Hiroyuki, Kitagawa, Kakuya, Laham, Roger, Kofoed, Klaus, Nomura, Cesar, Sakuma, Hajime, Yoshioka, Kunihiro, Mehra, Vishal C., Jinzaki, Masahiro, Kuribayashi, Sachio, Laule, Michael, Paul, Narinder, Scholte, Arthur J., Cerci, Rodrigo, Hoe, John, Tan, Swee Yaw, Rybicki, Frank J., Matheson, Matthew B., Vavere, Andrea L., Arai, Andrew E., Miller, Julie M., Cox, Christopher, Brinker, Jeffrey, Clouse, Melvin E., Di Carli, Marcelo, Lima, João A.C., and Arbab-Zadeh, Armin

Abstract

Background: Few data exist on long-term outcome in patients undergoing combined coronary CT angiography (CTA) and myocardial CT perfusion imaging (CTP) as well as invasive coronary angiography (ICA) and single photon emission tomography (SPECT). Methods: At 16 centers, 381 patients were followed for major adverse cardiac events (MACE) for the CORE320 study. All patients underwent coronary CTA, CTP, and SPECT before ICA within 60 days. Prognostic performance according binary results (normal/abnormal) was assessed by 5-year major cardiovascular events (MACE) free survival and area under the receiver-operating-characteristic curve (AUC). Results: Follow up beyond 2-years was available in 323 patients. MACE-free survival rate was greater among patients with normal combined CTA-CTP findings compared to ICA-SPECT: 85 vs. 80% (95% confidence interval [CI] for difference 0.1, 11.3) though event-free survival time was similar (4.54 vs. 4.37 years, 95% CI for difference: -0.03, 0.36). Abnormal results by combined CTA-CTP was associated with 3.83 years event-free survival vs. 3.66 years after abnormal combined ICA-SPECT (95% CI for difference: -0.05, 0.39). Predicting MACE by AUC also was similar: 65 vs. 65 (difference 0.1; 95% CI -4.6, 4.9). When MACE was restricted to cardiovascular death, myocardial infarction, or stroke, AUC for CTA-CTP was 71 vs. 60 by ICA-SPECT (difference 11.2; 95% CI -1.0, 19.7). Conclusions: Combined CTA-CTP evaluation yields at least equal 5-year prognostic information as combined ICA-SPECT assessment in patients presenting with suspected coronary artery disease. Noninvasive cardiac CT assessment may eliminate the need for diagnostic cardiac catheterization in many patients. Clinical trial registration: NCT00934037.

Published
2021

27. Computed tomography angiography and perfusion to assess coronary artery stenosis causing perfusion defects by single photon emission computed tomography: the CORE320 study

Author

Rochitte, Carlos E., George, Richard T., Chen, Marcus Y., Arbab-Zadeh, Armin, Dewey, Marc, Miller, Julie M., Niinuma, Hiroyuki, Yoshioka, Kunihiro, Kitagawa, Kakuya, Nakamori, Shiro, Laham, Roger, Vavere, Andrea L., Cerci, Rodrigo J., Mehra, Vishal C., Nomura, Cesar, Kofoed, Klaus F., Jinzaki, Masahiro, Kuribayashi, Sachio, de Roos, Albert, Laule, Michael, Tan, Swee Yaw, Hoe, John, Paul, Narinder, Rybicki, Frank J., Brinker, Jeffery A., Arai, Andrew E., Cox, Christopher, Clouse, Melvin E., Di Carli, Marcelo F., and Lima, Joao A.C.

Published
2014
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29. Diagnostic performance of coronary angiography by 64-row CT angiography

Author

Miller, Julie M., Rochitte, Carlos E., Dewey, Marc, Arbab-Zadeh, Armin, Hiroyuki Niinuma, Gottlieb, Iian, Paul, Narinder, Clouse, Melvin E., Shapiro, Edward P., Hoe, John, Lardo, Albert C., Bush, David E., de Roos, Albert, Cox, Christopher, Brinker, Jeffery, and Lima, Joao A.C.

Subjects
Coronary heart disease -- Care and treatment, Angiography -- Usage, Angiography -- Health aspects, Angiography -- Research
Abstract

The study aims to evaluate the accuracy of 64-row CT angiography in patients with suspected coronary heart disease. The results indicate that multidetector CT angiography is accurate in detecting obstructive coronary heart disease even though it cannot replace conventional coronary angiography.

Published
2008

33. 2012 American college of cardiology foundation/society for cardiovascular angiography and interventions expert consensus document on cardiac catheterization laboratory standards update: American college of cardiology foundation task force on expert consensus documents society of thoracic surgeons society for vascular medicine

Author

Bashore, Thomas M., Balter, Stephen, Barac, Ana, Byrne, John G., Cavendish, Jeffrey J., Chambers, Charles E., Hermiller, James Bernard, Jr, Kinlay, Scott, Landzberg, Joel S., Laskey, Warren K., McKay, Charles R., Miller, Julie M., Moliterno, David J., Moore, John W.M., Oliver-McNeil, Sandra M., Popma, Jeffrey J., Tommaso, Carl L., Harrington, Robert A., Bates, Eric R., Bhatt, Deepak L., Bridges, Charles R., Eisenberg, Mark J., Ferrari, Victor A., Fisher, John D., Gardner, Timothy, Gentile, Federico, Gilson, Michael F., Hlatky, Mark A., Jacobs, Alice K., Kaul, Sanjay, Moliterno, David J., Mukherjee, Debabrata, Rosenson, Robert S., Weitz, Howard H., and Wesley, Deborah J.

Published
2012
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34. Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure: Rationale and design of CONNECT-HF

Author

DeVore, Adam D., primary, Granger, Bradi B., additional, Fonarow, Gregg C., additional, Al-Khalidi, Hussein R., additional, Albert, Nancy M., additional, Lewis, Eldrin F., additional, Butler, Javed, additional, Piña, Ileana L., additional, Heidenreich, Paul A., additional, Allen, Larry A., additional, Yancy, Cyde W., additional, Cooper, Lauren B., additional, Felker, G. Michael, additional, Kaltenbach, Lisa A., additional, McRae, A. Thomas, additional, Lanfear, David E., additional, Harrison, Robert W., additional, Kociol, Robb D., additional, Disch, Maghee, additional, Ariely, Dan, additional, Miller, Julie M., additional, Granger, Christopher B., additional, and Hernandez, Adrian F., additional

Published
2020
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35. Gene Therapy

Author

Donahue, J. Kevin, primary, McDonald, Amy D., additional, Fraser, Heather, additional, Rade, Jeffrey J., additional, Miller, Julie M., additional, and Heldman, Alan H., additional

Published
2007
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36. Focal modification of electrical conduction in the heart by viral gene transfer

Author

Kevin Donahue, J., Heldman, Alan W., Fraser, Heather, McDonald, Amy D., Miller, Julie M., Rade, Jeffrey J., Eschenhagen, Thomas, and Marban, Eduardo

Subjects
Arrhythmia -- Genetic aspects, Arrhythmia -- Care and treatment, Arrhythmia -- Research, Genetic transformation -- Usage, Genetic transformation -- Methods, Radiofrequency ablation -- Health aspects
Abstract

Modern treatment of cardiac arrhythmias is limited to pharmacotherapy, radiofrequency ablation, or implantable devices. Antiarrhythmic medications suppress arrhythmias, but their systemic effects are often poorly tolerated and their proarrhythmic tendencies increase mortality. Radiofrequency ablation can cure only a limited number of arrhythmias. Implantable devices can be curative for bradyarrhythmias and lifesaving for tachyarrhythmias, but require a lifetime commitment to repeated procedures, are a significant expense, and may lead to severe complications. One possibility is the use of gene therapy as an antiarrhythmic strategy. As an initial attempt to explore this option, we focused on genetic modification of the atrioventricular node. First, we developed an intracoronary perfusion model for gene delivery, building on our previous work in isolated cardiac myocytes and hearts perfused ex vivo. Using this method, we infected porcine hearts with Ad[beta]gal (recombinant adenovirus expressing Escherichia coli [beta]-galactosidase) or with AdG[sub.i] (adenovirus encoding the G[alpha][sub.i2] subunit). We hypothesized that excess G[alpha][sub.i2] would mimic the effects of [beta]-adreneric antagonists, in effect creating a localized [beta]-blockade. G[alpha][sub.i2] overexpression suppressed baseline atrioventricular conduction and slowed the heart rate during atrial fibrillation without producing complete heart block. In contrast, expression of the reporter gene [beta]-galactosidase had no electrophysiological effects. Our results demonstrate the feasibility of using myocardial gene transfer strategies to treat common arrhythmias., Author(s): J. Kevin Donahue (corresponding author) [1, 2]; Alan W. Heldman [2]; Heather Fraser [1]; Amy D. McDonald [1]; Julie M. Miller [2]; Jeffrey J. Rade [2]; Thomas Eschenhagen [3]; [...]

Published
2000
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39. Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998

Author

Alexander, John H., Greenbaum, Adam B., Hudson, Michael P., Kong, David F., Miller, Julie M., Tung, Chen Y., and Whellan, David J.

Subjects
Cardiology, Universities and colleges, Health
Abstract

Byline: John H. Alexander, Adam B. Greenbaum, Michael P. Hudson, David F. Kong, Julie M. Miller, Chen Y. Tung, David J. Whellan Author Affiliation: Durham, NC Article Note: (footnote) [star] From the Division of Cardiology, Department of Medicine, Duke University Medical Center., [star][star] Am Heart J 1998;136:176-9. , a 0002-8703/98/$5.00 + 0 4/1/91704

Published
1998

42. TransRadial Education And Therapeutics (TREAT): Shifting the balance of safety and efficacy of antithrombotic agents in percutaneous coronary intervention: A report from the Cardiac Safety Research Consortium

Author

Hess, Connie N., Rao, Sunil V., Kong, David F., Miller, Julie M., Anstrom, Kevin J., Bertrand, Olivier F., Collet, Jean-Philippe, Effron, Mark B., Eloff, Benjamin C., Fadiran, Emmanuel O., Farb, Andrew, Gilchrist, Ian C., Holmes, David R., Jacobs, Alice K., Kaul, Prashant, Newby, Kristin L., Rutledge, David R., Tavris, Dale R., Tsai, Thomas T., White, Roseann M., Peterson, Eric D., and Krucoff, Mitchell W.

Published
2013
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43. Coronary Calcium Characteristics as Predictors of Major Adverse Cardiac Events in Symptomatic Patients:Insights From the CORE320 Multinational Study

Author

Lo-Kioeng-Shioe, Mallory S., Vavere, Andrea L., Arbab-Zadeh, Armin, Schuijf, Joanne D., Rochitte, Carlos E., Chen, Marcus Y., Rief, Matthias, Kofoed, Klaus F., Clouse, Melvin E., Scholte, Arthur J., Miller, Julie M., Betoko, Aisha, Blaha, Michael J., Cox, Christopher, Deckers, Jaap W., Lima, Joao A.C., Lo-Kioeng-Shioe, Mallory S., Vavere, Andrea L., Arbab-Zadeh, Armin, Schuijf, Joanne D., Rochitte, Carlos E., Chen, Marcus Y., Rief, Matthias, Kofoed, Klaus F., Clouse, Melvin E., Scholte, Arthur J., Miller, Julie M., Betoko, Aisha, Blaha, Michael J., Cox, Christopher, Deckers, Jaap W., and Lima, Joao A.C.

Abstract

Background: The predictive value of coronary artery calcium (CAC) has been widely studied; however, little is known about specific characteristics of CAC that are most predictive. We aimed to determine the independent associations of Agatston score, CAC volume, CAC area, CAC mass, and CAC density score with major adverse cardiac events in patients with suspected coronary artery disease. Methods and Results: A total of 379 symptomatic participants, aged 45 to 85 years, referred for invasive coronary angiography, who underwent coronary calcium scanning and computed tomography angiography as part of the CORE320 (Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320 Detector Computed Tomography) study, were included. Agatston score, CAC volume, area, mass, and density were computed on noncontrast images. Stenosis measurements were made on contrast-enhanced images. The primary outcome of 2-year major adverse cardiac events (30 revascularizations [>182 days of index catheterization], 5 myocardial infarctions, 1 cardiac death, 9 hospitalizations, and 1 arrhythmia) occurred in 32 patients (8.4%). Associations were estimated using multivariable proportional means models. Median age was 62 (interquartile range, 56–68) years, 34% were women, and 56% were white. In separate models, the Agatston, volume, and density scores were all significantly associated with higher risk of major adverse cardiac events after adjustment for age, sex, race, and statin use; density was the strongest predictor in all CAC models. CAC density did not provide incremental value over Agatston score after adjustment for diameter stenosis, age, sex, and race. Conclusions: In symptomatic patients, CAC density was the strongest independent predictor of major adverse cardiac events among CAC scores, but it did not provide incremental value beyond the Agatston score after adjustment for diameter stenosis.

Published
2019

44. The DNA strand in DNA.RNA hybrid duplexes is neither B-form nor A-form in solution

Author

Salazar, Miguel, Fedoroff, Oleg Y., Miller, Julie M., Ribiero, N. Susan, and Reid, Brian R.

Subjects
Nucleic acid hybridization -- Research, Conformational analysis -- Research, Biological sciences, Chemistry
Abstract

The structure of the DNA.RNA hybrid (GTCACATG).(caugugac) was analyzed using J-coupling and two-dimensional-NOE studies. Results indicated that the duplex did not exhibit a B-form conformation on solution which is converse to previous studies on the central hexamer. RNA residues retained their conformation although DNA sugars assumed an intermediate conformation at the O4 prime-endo range. These suggested the influence of the RNA strand on the conformation of its DNA counterpart. The DNA.RNA hybrid duplexes do not exhibit an all-C2-endo B type or an all C3-endo A type of conformmation in solution.

Published
1993

45. Financial Incentives to Increase Stool Collection Rates for Microbiome Studies in Adult Bone Marrow Transplant Patients

Author

Thompson, Jillian C., primary, Ren, Yi, additional, Romero, Kristi M., additional, Lew, Meagan V., additional, Bush, Amy T., additional, Messina, Julia A., additional, Jung, Sin-Ho, additional, Miller, Julie M., additional, Zenko, Zachary, additional, Jenq, Robert R., additional, Peled, Jonathan U., additional, van den Brink, Marcel R.M., additional, Chao, Nelson J., additional, and Sung, Anthony D., additional

Published
2019
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46. Coronary Calcium Characteristics as Predictors of Major Adverse Cardiac Events in Symptomatic Patients: Insights From the CORE320 Multinational Study

Author

Lo‐Kioeng‐Shioe, Mallory S., primary, Vavere, Andrea L., additional, Arbab‐Zadeh, Armin, additional, Schuijf, Joanne D., additional, Rochitte, Carlos E., additional, Chen, Marcus Y., additional, Rief, Matthias, additional, Kofoed, Klaus F., additional, Clouse, Melvin E., additional, Scholte, Arthur J., additional, Miller, Julie M., additional, Betoko, Aisha, additional, Blaha, Michael J., additional, Cox, Christopher, additional, Deckers, Jaap W., additional, and Lima, Joao A. C., additional

Published
2019
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47. Prognostic Value of Combined CT Angiography and Myocardial Perfusion Imaging versus Invasive Coronary Angiography and Nuclear Stress Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events: The CORE320 Multicenter Study

Author

Chen, Marcus Y., Rochitte, Carlos E., Arbab-Zadeh, Armin, Dewey, Marc, George, Richard T., Miller, Julie M., Niinuma, Hiroyuki, Yoshioka, Kunihiro, Kitagawa, Kakuya, Sakuma, Hajime, Laham, Roger, Vavere, Andrea L., Cerci, Rodrigo J., Mehra, Vishal C., Nomura, Cesar, Kofoed, Klaus F., Jinzaki, Masahiro, Kuribayashi, Sachio, Scholte, Arthur J., Laule, Michael, Tan, Swee Yaw, Hoe, John, Paul, Narinder, Rybicki, Frank J., Brinker, Jeffrey A., Arai, Andrew E., Matheson, Matthew B., Cox, Christopher, Clouse, Melvin E., Di Carli, Marcelo F., and Lima, João A. C.

Subjects
Male, Tomography, Emission-Computed, Single-Photon, Computed Tomography Angiography, Hemodynamics, Myocardial Perfusion Imaging, Coronary Artery Disease, Middle Aged, Coronary Angiography, Prognosis, Sensitivity and Specificity, Survival Analysis, Surveys and Questionnaires, Humans, Female, Prospective Studies, Original Research, Aged
Abstract

Purpose To compare the prognostic importance (time to major adverse cardiovascular event [MACE]) of combined computed tomography (CT) angiography and CT myocardial stress perfusion imaging with that of combined invasive coronary angiography (ICA) and stress single photon emission CT myocardial perfusion imaging. Materials and Methods This study was approved by all institutional review boards, and written informed consent was obtained. Between November 2009 and July 2011, 381 participants clinically referred for ICA and aged 45-85 years were enrolled in the Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-Detector Row Computed Tomography (CORE320) prospective multicenter diagnostic study. All images were analyzed in blinded independent core laboratories, and a panel of physicians adjudicated all adverse events. MACE was defined as revascularization (30 days after index ICA), myocardial infarction, or cardiac death; hospitalization for chest pain or congestive heart failure; or arrhythmia. Late MACE was defined similarly, except for patients who underwent revascularization within the first 182 days after ICA, who were excluded. Comparisons of 2-year survival (time to MACE) used standard Kaplan-Meier curves and restricted mean survival times bootstrapped with 2000 replicates. Results An MACE (49 revascularizations, five myocardial infarctions, one cardiac death, nine hospitalizations for chest pain or congestive heart failure, and one arrhythmia) occurred in 51 of 379 patients (13.5%). The 2-year MACE-free rates for combined CT angiography and CT perfusion findings were 94% negative for coronary artery disease (CAD) versus 82% positive for CAD and were similar to combined ICA and single photon emission CT findings (93% negative for CAD vs 77% positive for CAD, P.001 for both). Event-free rates for CT angiography and CT perfusion versus ICA and single photon emission CT for either positive or negative results were not significantly different for MACE or late MACE (P.05 for all). The area under the receiver operating characteristic curve (AUC) for combined CT angiography and CT perfusion (AUC = 68; 95% confidence interval [CI]: 62, 75) was similar (P = .36) to that for combined ICA and single photon emission CT (AUC = 71; 95% CI: 65, 79) in the identification of MACE at 2-year follow-up. Conclusion Combined CT angiography and CT perfusion enables similar prediction of 2-year MACE, late MACE, and event-free survival similar to that enabled by ICA and single photon emission CT.

Published
2017

48. Coronary Artery Disease: Analysis of Diagnostic Performance of CT Perfusion and MR Perfusion Imaging in Comparison with Quantitative Coronary Angiography and SPECT—Multicenter Prospective Trial

Author

Rief, Matthias, primary, Chen, Marcus Y., additional, Vavere, Andrea L., additional, Kendziora, Benjamin, additional, Miller, Julie M., additional, Bandettini, W. Patricia, additional, Cox, Christopher, additional, George, Richard T., additional, Lima, João, additional, Di Carli, Marcelo, additional, Plotkin, Michail, additional, Zimmermann, Elke, additional, Laule, Michael, additional, Schlattmann, Peter, additional, Arai, Andrew E., additional, and Dewey, Marc, additional

Published
2018
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50. Prognostic value of combined CT angiography and myocardial perfusion imaging versus invasive coronary angiography and nuclear stress perfusion imaging in the prediction of major adverse cardiovascular events:The CORE320 multicenter study

Author

Chen, Marcus Y., Rochitte, Carlos E., Arbab-Zadeh, Armin, Dewey, Marc, George, Richard T., Miller, Julie M., Niinuma, Hiroyuki, Yoshioka, Kunihiro, Kitagawa, Kakuya, Sakuma, Hajime, Laham, Roger, Vavere, Andrea L., Cerci, Rodrigo J., Mehra, Vishal C., Nomura, Cesar, Kofoed, Klaus F., Jinzaki, Masahiro, Kuribayashi, Sachio, Scholte, Arthur J., Laule, Michael, Tan, Swee Yaw, Hoe, John, Paul, Narinder, Rybicki, Frank J., Brinker, Jeffrey A., Arai, Andrew E., Matheson, Matthew B., Cox, Christopher, Clouse, Melvin E., Di Carli, Marcelo F., Lima, João A.C., Chen, Marcus Y., Rochitte, Carlos E., Arbab-Zadeh, Armin, Dewey, Marc, George, Richard T., Miller, Julie M., Niinuma, Hiroyuki, Yoshioka, Kunihiro, Kitagawa, Kakuya, Sakuma, Hajime, Laham, Roger, Vavere, Andrea L., Cerci, Rodrigo J., Mehra, Vishal C., Nomura, Cesar, Kofoed, Klaus F., Jinzaki, Masahiro, Kuribayashi, Sachio, Scholte, Arthur J., Laule, Michael, Tan, Swee Yaw, Hoe, John, Paul, Narinder, Rybicki, Frank J., Brinker, Jeffrey A., Arai, Andrew E., Matheson, Matthew B., Cox, Christopher, Clouse, Melvin E., Di Carli, Marcelo F., and Lima, João A.C.

Abstract

Purpose: To compare the prognostic importance (time to major adverse cardiovascular event [MACE]) of combined computed tomography (CT) angiography and CT myocardial stress perfusion imaging with that of combined invasive coronary angiography (ICA) and stress single photon emission CT myocardial perfusion imaging. Materials and Methods: This study was approved by all institutional review boards, and written informed consent was obtained. Between November 2009 and July 2011, 381 participants clinically referred for ICA and aged 45-85 years were enrolled in the Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-Detector Row Computed Tomography (CORE320) prospective multicenter diagnostic study. All images were analyzed in blinded independent core laboratories, and a panel of physicians adjudicated all adverse events. MACE was defined as revascularization (>30 days after index ICA), myocardial infarction, or cardiac death; hospitalization for chest pain or congestive heart failure; or arrhythmia. Late MACE was defined similarly, except for patients who underwent revascularization within the first 182 days after ICA, who were excluded. Comparisons of 2-year survival (time to MACE) used standard Kaplan-Meier curves and restricted mean survival times bootstrapped with 2000 replicates. Results: An MACE (49 revascularizations, five myocardial infarctions, one cardiac death, nine hospitalizations for chest pain or congestive heart failure, and one arrhythmia) occurred in 51 of 379 patients (13.5%). The 2-year MACE-free rates for combined CT angiography and CT perfusion findings were 94% negative for coronary artery disease (CAD) versus 82% positive for CAD and were similar to combined ICA and single photon emission CT findings (93% negative for CAD vs 77% positive for CAD, P < .001 for both). Event-free rates for CT angiography and CT perfusion versus ICA and single photon emission CT for either positive or negative results were not

Published
2017

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