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156 results on '"Millar, Seán R."'

20. Anthropometric measures, predicted visceral adipose tissue and biomarkers of chronic inflammation.

Author

Millar, Seán R., Perry, Ivan J., and Phillips, Catherine M.

Subjects
*ADIPOSE tissues, *LEUKOCYTE count, *ADIPOSE tissue diseases
Abstract

Background: Evidence has linked low‐grade systemic inflammation and visceral adipose tissue (VAT) with development of chronic conditions. Cytokines and select proteins released by VAT may promote a low‐grade inflammatory response. A number of equations have been developed to estimate VAT levels. In this study, we compared predicted VAT equation relationships with biomarkers of inflammation. Methods: This was a cross‐sectional study of 2038 men and women aged 46–73 years. Correlation and linear regression analyses were performed to examine inflammatory biomarker relationships with four commonly assessed anthropometric measures and 10 predicted VAT equations. Results: Compared with anthropometric measures, predicted VAT equations were found to explain a greater proportion of variance in CRP (R2 =.075, p =.001), IL‐6 (R2 =.060, p =.001), TNF‐α (R2 =.017, p =.005), resistin (R2 =.011, p =.012), monocyte (R2 =.027, p =.001), eosinophil (R2 =.012, p =.01) and basophil (R2 =.015, p =.002) levels in males, and a greater variance in concentrations of C3 (R2 =.175, p =.001), IL‐6 (R2 =.090, p =.001), TNF‐α (R2 =.036, p =.001), adiponectin (R2 =.121, p =.001), the adiponectin‐to‐leptin ratio (R2 =.444, p =.001), resistin (R2 =.025, p =.001), white blood cell count (R2 =.057, p =.001), neutrophils (R2 =.061, p =.001) and lymphocytes (R2 =.020, p =.001) in females. Conclusion: Equations for assessing VAT levels might be useful to characterise metabolic health. Further studies that examine predicted VAT relationships with disease and mortality outcomes are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Examining the Usefulness of the Charlson Comorbidity Index to Predict Early Mortality in Patients with Acute Myeloid Leukaemia

Author

Bakri Mohamed, Mohamed, primary, Millar, Seán R, additional, Mykytiv, Vitaliy, additional, McMorrow, Rose, additional, Donnelly, Conan, additional, Walsh, Paul M, additional, O'Leary, Eamonn, additional, Orfali, Nina, additional, Murphy, Philip, additional, Browne, Paul V., additional, Quinn, John, additional, O'Gorman, Peter, additional, Clifford, Ruth, additional, El Hassadi, Ezzat, additional, Gilligan, Oonagh, additional, Krawczyk, Janusz, additional, O'Dwyer, Michael E., additional, Szegezdi, Eva, additional, and Cahill, Mary R, additional

Published
2021
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43. Comparing Cannabis Use Disorder in the General Population with Cannabis Treatment Seekers Using Multi-Source National Datasets: Who Receives Treatment?

Author

Mongan, Deirdre, Carew, Anne Marie, O'Neill, Derek, Millar, Seán R., Lyons, Suzi, Galvin, Brian, and Smyth, Bobby P.

Subjects
MARIJUANA abuse, DEMOGRAPHIC surveys
Abstract

Introduction: Given the increased prevalence of cannabis use in Ireland and increase in cannabis potency, this study aimed to estimate the size of the potential population in Ireland that may be in need of cannabis treatment and the percentage of people with cannabis use disorder (CUD) who actually access treatment. We also compared the profile of those with CUD in the general population to those who receive treatment for their cannabis use to explore whether certain subgroups are more or less likely to enter treatment. Method: This was a retrospective, multi-source database study. Data were obtained from (1) Ireland's 2014/2015 national general population survey (GPS) on drug use and (2) treatment data from the Irish National Drug Treatment Reporting System (NDTRS) for 2015. The profiles of GPS cases with CUD and NDTRS cases were compared using 2-sided t tests designed for independent samples. Results: The prevalence of last year cannabis use among adults aged 15 and older was 6.5% and the prevalence of CUD was 2.6%, representing 94,515 of the Irish population. A total of 4,761 cases entered treatment for problem cannabis use. NDTRS treatment cases were significantly more likely than GPS cases to be unemployed (63.7% vs. 26.6%) and have no or primary level only educational attainment (56.3% vs. 21.2%). Over half (53.3%) of NDTRS cases first used cannabis before the age of 15 years, compared to 14.7% of CUD cases in the population. Discussion/Conclusion: Our findings suggest that earlier users and those with more complex or disadvantaged lives are more likely to seek treatment. A broad population health approach that engages multiple sectors such as health, social welfare, and education is recommended to ensure that there is increased opportunity for people with CUD to be identified and signposted towards treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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