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Your search keyword '"Milkie D"' showing total 10 results
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10 results on '"Milkie D"'

2. Carbon Nanotube Aerogels

Author

Bryning, M. B., primary, Milkie, D. E., additional, Islam, M. F., additional, Hough, L. A., additional, Kikkawa, J. M., additional, and Yodh, A. G., additional

Published
2007
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10. A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster.

Author

Zheng Z, Lauritzen JS, Perlman E, Robinson CG, Nichols M, Milkie D, Torrens O, Price J, Fisher CB, Sharifi N, Calle-Schuler SA, Kmecova L, Ali IJ, Karsh B, Trautman ET, Bogovic JA, Hanslovsky P, Jefferis GSXE, Kazhdan M, Khairy K, Saalfeld S, Fetter RD, and Bock DD

Subjects
Animals, Brain anatomy & histology, Brain diagnostic imaging, Dendrites, Drosophila melanogaster anatomy & histology, Female, Microscopy, Electron methods, Mushroom Bodies, Neurons, Smell physiology, Software, Brain Mapping methods, Connectome methods, Nerve Net anatomy & histology
Abstract

Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only electron microscopy (EM) enables complete, unbiased mapping of synaptic connectivity; however, the fly brain is too large for conventional EM. We developed a custom high-throughput EM platform and imaged the entire brain of an adult female fly at synaptic resolution. To validate the dataset, we traced brain-spanning circuitry involving the mushroom body (MB), which has been extensively studied for its role in learning. All inputs to Kenyon cells (KCs), the intrinsic neurons of the MB, were mapped, revealing a previously unknown cell type, postsynaptic partners of KC dendrites, and unexpected clustering of olfactory projection neurons. These reconstructions show that this freely available EM volume supports mapping of brain-spanning circuits, which will significantly accelerate Drosophila neuroscience. VIDEO ABSTRACT., (Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2018
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