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214 results on '"Milivojevic, Milan"'

5. Cell jamming and unjamming in development: physical aspects

Author

Pajic-Lijakovic, Ivana and Milivojevic, Milan

Subjects
Quantitative Biology - Cell Behavior
Abstract

Collective cell migration is essential for a wide range of biological processes such as: morphogenesis, wound healing, and cancer spreading. However, it is well known that migrating epithelial collectives frequently undergo jamming, stay trapped some period of time, and then start migration again. Consequently, only a part of epithelial cells actively contributes to the tissue development. In contrast to epithelial cells, migrating mesenchymal collectives successfully avoid the jamming. It has been confirmed that the epithelial unjamming cannot be treated as the epithelial-to-mesenchymal transition. Some other mechanism is responsible for the epithelial jamming/unjamming. Despite extensive research devoted to study the cell jamming/unjamming, we still do not understand the origin of this phenomenon. The origin is connected to physical factors such as: the cell compressive residual stress accumulation and surface characteristics of migrating (unjamming) and resting (jamming) epithelial clusters which depend primarily on the strength of cell-cell adhesion contacts and cell contractility. The main goal of this theoretical consideration is to clarify these cause-consequence relations., Comment: 18 pages, 4 figures

Published
2023

6. Physics of collective cell migration

Author

Pajic-Lijakovic, Ivana and Milivojevic, Milan

Subjects
Quantitative Biology - Cell Behavior, Quantitative Biology - Tissues and Organs
Abstract

Movement of cell clusters along extracellular matrices (ECM) during tissue development, wound healing, and early stage of cancer invasion involve various inter-connected migration modes such as: (1) cell movement within clusters, (2) cluster extension (wetting) and compression (de-wetting), and (3) directional cluster movement. It has become increasingly evident that dilational and volumetric viscoelasticity of cell clusters and their surrounding substrate significantly influence these migration modes through physical parameters such as: cell and matrix surface tensions, interfacial tension between cells and substrate, gradients of surface and interfacial tensions, as well as, the accumulation of cell and matrix residual stresses. Inhomogeneous distribution of cell surface tension along migrating cell cluster can appear as a consequence of different strength of cell-cell adhesion contacts and cell contractility between leader and follower cells. While the directional cell migration caused by the matrix stiffness gradient (i.e. durotaxis) has been widely elaborated, the structural changes of matrix surface caused by cell tractions which lead to the generation of the matrix surface tension gradient has not been considered yet. The main goal of this theoretical consideration is to clarify the roles of various physical parameters in collective cell migration based on the formulating biophysical model. This complex phenomenon is discussed on the model systems such as the movement of cell clusters on the collagen I gel matrix by simultaneously reviewing various experimental data with and without cells., Comment: 21 pages, 3 figures, 2 tables

Published
2023

7. Active wetting of epithelial tissues: modeling considerations

Author

Pajic-Lijakovic, Ivana and Milivojevic, Milan

Subjects
Quantitative Biology - Cell Behavior, Condensed Matter - Soft Condensed Matter, Physics - Biological Physics, Quantitative Biology - Tissues and Organs, review
Abstract

Morphogenesis, tissue regeneration and cancer invasion involve transitions in tissue morphology. These transitions, caused by collective cell migration (CCM), have been interpreted as active wetting/de-wetting transitions. This phenomenon is considered on model system such as wetting of cell aggregate on rigid substrate which includes cell aggregate movement and isotropic/anisotropic spreading of cell monolayer around the aggregate depending on the substrate rigidity and aggregate size. This model system accounts for the transition between 3D epithelial aggregate and 2D cell monolayer as a product of: (1) tissue surface tension, (2) surface tension of substrate matrix, (3) cell-matrix interfacial tension, (4) interfacial tension gradient, (5) viscoelasticity caused by CCM, and (6) viscoelasticity of substrate matrix. These physical parameters depend on the cell contractility and state of cell-cell and cell matrix adhesion contacts, as well as, the stretching/compression of cellular systems caused by CCM. Despite extensive research devoted to study cell wetting, we still do not understand interplay among these physical parameters which induces oscillatory trend of cell rearrangement. This review focuses on these physical parameters in governing the cell rearrangement in the context of epithelial aggregate wetting.de-wetting, and on the modelling approaches aimed at reproducing and understanding these biological systems. In this context, we do not only review previously-published bio-physics models for cell rearrangement caused by CCM, but also propose new extensions of those models in order to point out the interplay between cell-matrix interfacial tension and epithelial viscoelasticity and the role of the interfacial tension gradient in cell spreading., Comment: 25 pages, 2 figures, 1 table

Published
2022

8. Marangoni effect and cell spreading

Author

Pajic-Lijakovic, Ivana and Milivojevic, MIlan

Subjects
Quantitative Biology - Cell Behavior
Abstract

Cells are very sensitive to the shear stress (SS). However, undesirable SS is generated during physiological process such as collective cell migration (CCM) and influences the biological processes such as morphogenesis, wound healing and cancer invasion. Despite extensive research devoted to study the stress generation caused by CCM, we still do not fully understand the main cause of SS generation. An attempt is made here to offer some answers to these questions by considering the rearrangement of cell monolayers. The SS generation represents a consequence of natural and forced convection. While forced convection is dependent on cell speed, the natural convection is induced by the gradient of tissue surface tension. The phenomenon is known as the Marangoni effect. The gradient of tissue surface tension induces directed cell spreading from the regions of lower tissue surface tension to the regions of higher tissue surface tension. This directed cell migration is described by the Marangoni flux. The phenomenon has been recognized during the rearrangement of (1) epithelial cell monolayers and (2) mixed cell monolayers made by epithelial and mesenchymal cells. The consequence of the Marangoni effect is an intensive spreading of cancer cells through an epithelium. In this work, a review of existing literature about SS generation caused by CCM is given along with the assortment of published experimental findings, in order to invite experimentalists to test given theoretical considerations in multicellular systems., Comment: 7837 words, 3 figures, 1 table, 64 references

Published
2021

9. Viscoelasticity and cell swirling motion

Author

Pajic-Lijakovic, Ivana and Milivojevic, Milan

Subjects
Quantitative Biology - Tissues and Organs, Quantitative Biology - Cell Behavior
Abstract

Although collective cell migration (CCM) is a highly coordinated and fine-tuned migratory mode, instabilities in the form of cell swirling motion (CSM) often occur. The CSM represents a product of the active turbulence obtained at low Reynolds number which has a feedback impact to various processes such as morphogenesis, wound healing, and cancer invasion. The cause of this phenomenon is related to the viscoelasticity of multicellular systems in the context of cell residual stress accumulation. Particular interest of this work is to: (1) emphasize the roles of cell shear and normal residual stress accumulated during CCM in the appearance of CSM and (2) consider the dynamics of CSM from the standpoint of rheology. Inhomogeneous distribution of the cell residual stress leads to a generation the viscoelastic force which acts to suppress CCM and can induces the system rapid stiffening. This force together with the surface tension force and traction force is responsible for the appearance of the CSM. In this work, a review of existing literature about viscoelasticity caused by CCM is given along with assortment of published experimental findings, in order to invite experimentalists to test given theoretical considerations in multicellular systems., Comment: 26 pages, 4 figures, 7719 words

Published
2021

10. Surface activity of cancer cells: the fusion of two cell aggregates

Author

Pajic-Lijakovic, Ivana and Milivojevic, Milan

Subjects
Quantitative Biology - Cell Behavior
Abstract

Although a good comprehension of how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been generated, the impact of collective migration on cellular rearrangement from subcellular to supracellular level remains less understood. Thus, considering collective cell migration (CCM) of cancer mesenchymal cells on one side and healthy epithelial cells on the other during the fusion of two cell aggregates could result in a powerful tool in order to address the contribution of structural changes at subcellular level which influence the cellular rearrangements and help to understand this important, but still controversial topic. While healthy epithelial cells undergo volumetric cell rearrangement driven by the tissue surface tension, which results in a collision of opposite directed velocity front near the contact point between two cell aggregates, mesenchymal cells follow quite different scenario. These cells are capable of reducing the surface tension and undergo surface cell rearrangement. The main goal of this contribution is to discuss the origin of surface activity of cancer cells by accounting for the crosstalk between cell-cell and cell-ECM adhesion contacts influenced by the cell contractility., Comment: 18 pages, 6 figures,5535 words

Published
2021

19. Biopolymers for Drug Delivery

Author

Hasnain, Md Saquib, Ahmed, Syed Anees, Alkahtani, Saad, Milivojevic, Milan, Kandar, Chandi Charan, Dhara, Amal Kumar, Nayak, Amit Kumar, Ikhmayies, Shadia Jamil, Series Editor, Nayak, Amit Kumar, editor, and Hasnain, Md Saquib, editor

Published
2020
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22. List of contributors

Author

Abo Dena, Ahmed S., primary, Acquah, Caleb, additional, Ahmed, Tanvir, additional, Ajit, Azilah, additional, Al-Awthan, Yahya S., additional, Albuquerque, Tânia, additional, Anil, Sukumaran, additional, Apolonio–Hernandez, Nuvia Marina, additional, Atanase, Leonard Ionut, additional, Bahattab, Omar, additional, Behera, Anindita, additional, Bilal, Muhammad, additional, Bugarski, Branko, additional, Campa-Mada, A.C., additional, Carbajal-Valenzuela, Ireri Alejandra, additional, Carvajal-Millan, E., additional, Chen, Long, additional, Cheng, Wai Teng, additional, Colmenarez Lobo, Custodiana A., additional, Costa, Diana, additional, Costa, Eduardo, additional, Dalavi, Pandurang Appana, additional, Danquah, Michael K., additional, De Anda-Flores, Y., additional, Deshmukh, Harshal, additional, Dhara, Amal Kumar, additional, El-Sherbiny, Ibrahim M., additional, Faria, Rúben, additional, Feregrino-Pérez, Ana Angelica, additional, Figueroa-Pizano, M.D., additional, Gamage, D.A.S., additional, González-Arias, Beatriz, additional, Govindan, Natanamurugaraj, additional, Guevara-González, Ramón Gerardo, additional, Gutierrez-Chavez, Diana Vanesa, additional, Hasnain, Md Saquib, additional, Hossain, Shafiul, additional, Imran, Muhammad, additional, Iqbal, Hafiz M.N., additional, Jeevanandam, Jaison, additional, Jimenez-Hernandez, Alejandra, additional, Jin, Zhengyu, additional, Kabir, Sumaya F., additional, Kanny, Krishnan, additional, Lakkakula, Jaya, additional, Lizardi-Mendoza, J., additional, Machado, Manuela, additional, Madhujith, T., additional, Maniam, Gaanty Pragas, additional, Manzano, Verónica E., additional, Martínez-López, A.L., additional, Martínez-Robinson, K.G., additional, McClements, David Julian, additional, Miao, Ming, additional, Milivojevic, Milan, additional, Minhajul Islam, Md., additional, Mok Tsze Chung, Aurelie Sarah, additional, Mubarak, Mohammad S., additional, Muhammad, Naveed, additional, Munir, Hira, additional, Murugan, Sesha Subramanian, additional, Nayak, Amit Kumar, additional, Neves, Ana R., additional, Olatunde, Ahmed, additional, Pajic-Lijakovic, Ivana, additional, Pal, Dilipkumar, additional, Papagiannopoulos, Aristeidis, additional, Pintado, Manuela, additional, Popa, Marcel, additional, Qamar, Sarmad Ahmad, additional, Quintela, Telma, additional, Racovita, Stefania, additional, Rafeeq, Hamza, additional, Rahim, Mohd Hasbi Ab., additional, Rahman, Ashiqur, additional, Rahman, Mohammed Mizanur, additional, Raj, Khushboo, additional, Rane, Ajay Vasudeo, additional, Rascón-Chu, A., additional, Rauf, Abdur, additional, Repetto, Evangelina, additional, Rico-García, Enrique, additional, Saha, Supriyo, additional, Sazedul Islam, Md., additional, Shahruzzaman, Md., additional, Silva, Sara, additional, Sousa, Ângela, additional, Sulaiman, Ahmad Ziad, additional, Sultana, Sabrina, additional, Tan, Joash Ban Lee, additional, Tanori-Cordova, J., additional, Teo, Yong Kiat, additional, Tiwari, Himja, additional, torres-Pacheco, Irineo, additional, Tufail, Tabussam, additional, Vasiliu, Silvia, additional, Venkatesan, Jayachandran, additional, Vlassi, Eleni, additional, Wagh, Nilesh Shirish, additional, Wedamulla, N.E., additional, Yadav, Deepti, additional, and Yang, Zhongyu, additional

Published
2022
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24. Physics of cancer spreading through epithelium

Author

Pajic-Lijakovic, Ivana, Milivojevic, Milan, McClintock, Peter V. E., Pajic-Lijakovic, Ivana, Milivojevic, Milan, and McClintock, Peter V. E.

Abstract

Many cancers spread across the epithelium and physics is needed to describe the process. Cell dynamics at the normal epithelium/cancer biointerface play a crucial role in the progression of the disease. An altered arrangement of epithelial cells significantly impacts progression, so that a detailed understanding of the biological and physical mechanisms governing the interface dynamics provides a promising basis for cancer prevention. The biological mechanisms involve cell signalling and gene expression, while the physical mechanisms are associated with the interplay between physical properties such as the epithelium-cancer interfacial tension, the epithelial surface tension, and the compressive stress within the epithelium. Despite extensive in vitro research on epithelium/cancer co-cultured cell systems, the influence of these physical parameters on cell reorganization remains incomplete. This review provides an account of what is known about the physical processes involved in cell reorganization within epithelium/cancer cell clusters and the dissemination of cancer within co-cultured systems.

Published
2024

28. List of Contributors

Author

Akinyi, Teckla, primary, Balland, Martial, additional, Barriga, Elias H., additional, Betz, Timo, additional, Bhatt, Manish, additional, Borja, Cristian, additional, Boudou, Thomas, additional, Brochard-Wyart, Françoise, additional, Cappello, Giovanni, additional, Catheline, Stefan, additional, Clark, Andrew G., additional, Cloutier, Guy, additional, Espina, Jaime A., additional, Gonzalez-Rodriguez, David, additional, Grasland-Mongrain, Pol, additional, Guevorkian, Karine, additional, Milivojevic, Milan, additional, Moral, Elena, additional, Muñoz, Jose J., additional, Pajic-Lijakovic, Ivana, additional, Petrolli, Vanni, additional, and Saraiva, Joana E., additional

Published
2021
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32. Biopolymers for Drug Delivery

Author

Hasnain, Md Saquib, primary, Ahmed, Syed Anees, additional, Alkahtani, Saad, additional, Milivojevic, Milan, additional, Kandar, Chandi Charan, additional, Dhara, Amal Kumar, additional, and Nayak, Amit Kumar, additional

Published
2020
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41. List of contributors

Author

Abbasi, Yasir Faraz, primary, Ahmed, Syed Anees, additional, Aminabhavi, Tejraj M., additional, Anda-Flores, Yubia De, additional, Anil, Sukumaran, additional, Ansari, Mohammad Tahir, additional, Arafa, Mona F., additional, Bala, Esha, additional, Bera, Hriday, additional, Bugarski, Branko, additional, Campa-Mada, Alma C., additional, Carvajal-Millan, Elizabeth, additional, Castro, Pedro M., additional, Chandra Nandy, Bankim, additional, Chaturvedi, Kiran, additional, Chee, Bor Shin, additional, D'Accorso, Norma B., additional, De, Arnab, additional, de Barros Dias, Mabilly Cox Holanda, additional, Dey, Sanjay, additional, Dugge, Tanavi, additional, El Maghraby, Gamal M., additional, Ferreira da Silva, Classius, additional, Ganguly, Kuntal, additional, Gomez-Rodriguez, Gabriel H., additional, Hans, Neha, additional, Hasnain, Md Saquib, additional, Jain, Ankit, additional, Jain, Sanjay K., additional, Jana, Sougata, additional, Jana, Subrata, additional, Kumar Dubey, Sunil, additional, Lazim, Nurul Asmak Md, additional, Liu, Yiyang, additional, Lizardi-Mendoza, Jaime, additional, Lowe, Baboucarr, additional, Madureira, Ana Raquel, additional, Maiti, Sabyasachi, additional, Manzano, Verónica E., additional, Milivojevic, Milan, additional, Morás, Ana Moira, additional, More, Uttam A., additional, Moura, Dinara Jaqueline, additional, Mozammil Hasnain, S M, additional, Muhamad, Ida Idayu, additional, Naik, Balaram, additional, Nanda, Sitansu Sekhar, additional, Narayan De, Jayanta, additional, Nayak, Amit Kumar, additional, Noolvi, Malleshappa N., additional, Nugent, Michael, additional, Pacho, María Natalia, additional, Pajic-Lijakovic, Ivana, additional, Panda, Pritish Kumar, additional, Pang, Zhiqing, additional, Parcha, Versha, additional, Patra, Sanjukta, additional, Pedroso Yoshida, Cristiana Maria, additional, Pintado, Manuela E., additional, Rao, Sneha S., additional, Rao, M.E. Bhanoji, additional, Rascón-Chu, Agustin, additional, Reddy, Kakarla Raghava, additional, Rekha, P.D., additional, Samanta, Amalesh, additional, Sami, Farheen, additional, Saraf, Shivani, additional, Sarangi, Manoj Kumar, additional, Sarmento, Bruno, additional, Selvakumaran, Suguna, additional, Sen, Kalyan Kumar, additional, Severino, Patrícia, additional, Shariatinia, Zahra, additional, Shiva, Niharika, additional, Singha, Siddhartha, additional, Singhvi, Gautam, additional, Souto, Eliana Maria, additional, Steffens, Luiza, additional, Tabish, Mohammad, additional, Tanori-Cordova, Judith, additional, Tiwari, Ankita, additional, Venkatesan, Jayachandran, additional, Verma, Amit, additional, Yassue-Cordeiro, Patrícia Hissae, additional, Yi, Dong Kee, additional, and Zhu, Yuefei, additional

Published
2019
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42. List of Contributors

Author

Agarwal, Charu, primary, Akturk, Omer, additional, Albers, Rebecca Faggion, additional, Andronescu, Ecaterina, additional, Arcos, D., additional, Balanc, Bojana, additional, Batra, Sonali, additional, Bugarski, Branko, additional, Csóka, Levente, additional, da Silva, Mônica Freitas, additional, da Silva, Tiago Luis, additional, de Jesus, Marcelo Bispo, additional, de Moraes, Daniel Angeli, additional, de Queiróz, Daniely Ferreira, additional, de Souza, Caio Guilherme Secco, additional, Erdemli, Ozge, additional, Fang, Ruina, additional, Florea, Denisa-Alexandra, additional, Gómez-Cerezo, N., additional, Grumezescu, Alexandru Mihai, additional, Grumezescu, Valentina, additional, Hatami, Mohammad, additional, Heeg, Jan, additional, Hryniewicz, Tadeusz, additional, Jose, Ajith James, additional, Kellomäki, Minna, additional, Kordas, Krisztian, additional, Kumar, Kuldeep, additional, Levic, Steva, additional, Liu, Wei, additional, Lorite, Gabriela Simone, additional, Ma, Jinju, additional, Malavika, C., additional, Malorny, Winfried, additional, Mendonça, Monique Culturato Padilha, additional, Milivojevic, Milan, additional, Mohl, Melinda, additional, Nedovic, Viktor, additional, Neves, Herbert Rodrigo, additional, Owaid, Mustafa Nadhim, additional, Pajic-Lijakovic, Ivana, additional, Perecin, Caio José, additional, Pitkänen, Olli, additional, Radosevic, Radenko, additional, Rawat, Shweta, additional, Rokosz, Krzysztof, additional, Saxena, Jyoti, additional, Schütz, Antje, additional, Sharma, Sumit, additional, Singh, Apoorva, additional, Singh, Rupinder, additional, Singh, Sunpreet, additional, Souza Junior, João Batista, additional, Stepczyńska, Magdalena, additional, Stevanovic-Dajic, Zora, additional, Tapio Koivisto, Janne, additional, Thomas, Paulose, additional, Trifkovic, Kata, additional, Tunali, Beste Cagdas, additional, Vallet-Regí, M., additional, Varanda, Laudemir Carlos, additional, Verma, Neelam, additional, Wienecke, Marion, additional, and Yao, Xinding, additional

Published
2019
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45. Physics of cancer spreading through epithelium.

Author

Pajic-Lijakovic, Ivana, Milivojevic, Milan, and McClintock, Peter V. E.

Subjects
*INTERFACIAL tension, *INTERFACE dynamics, *CANCER invasiveness, *SURFACE tension, *EPITHELIAL cells
Abstract

Many cancers spread across the epithelium and physics is needed to describe the process. Cell dynamics at the normal epithelium/cancer biointerface play a crucial role in the progression of the disease. An altered arrangement of epithelial cells significantly impacts progression, so a detailed understanding of the biological and physical mechanisms governing the interface dynamics provides a promising basis for cancer prevention. The biological mechanisms involve cell signalling and gene expression, while the physical mechanisms are associated with the interplay between physical properties such as the epithelium-cancer interfacial tension, the epithelial surface tension, and the compressive stress within the epithelium. Despite extensive in vitro research on epithelium/cancer co-cultured cell systems, the influence of these physical parameters on cell reorganisation remains incomplete. This review provides an account of what is known about the physical processes involved in cell reorganisation within epithelium/cancer cell clusters and the dissemination of cancer within co-cultured systems. [ABSTRACT FROM AUTHOR]

Published
2023
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