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3 results on '"Militao, G. C. G."'

2. Cytotoxic Flavonoids from Platymiscium floribundum

Author

Falcao, M. J. C., Pouliquem, Y. B. M., Lima, M. A. S., Gramosa, N. V., Costa-Lotufo, L. V., Militao, G. C. G., Pessoa, C., Moraes, M. Odorico de, and Silveira, E. R.

Abstract

Two new isoflavonoids, 7-hydroxy-6,4‘-dimethoxy-isoflavonequinone (1) and 2‘-hydroxy-6,4‘,6‘ ‘,4‘ ‘‘-tetramethoxy-[7-O-7‘ ‘]-bisisoflavone (2), and seven other known flavonoids, 3-hydroxy-9-methoxypterocarpan (medicarpin), 3,10-dihydroxy-9-methoxypterocarpan, 3,9-dimethoxypterocarpan (homopterocarpin) (3), 2,3,9-trimethoxypterocarpan (4), 3,4-dihydroxy-9-methoxypterocarpan (vesticarpan) (5), 2‘,4,4‘-trihydroxychalcone (isoliquiritigenin), and 7,4‘-dihydroxyflavanone (liquiritigenin) (6), were isolated from the heartwood of Platymiscium floribundum. The structures of compounds 1 and 2 were established by spectroscopic methods. Compounds 3−6 showed cytotoxic activity when evaluated against five human cancer cell lines in vitro.

Published
2005

3. Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS)

Author

Daisy Jereissati Barbosa Lima, Edigênia Cavalcante da Cruz Araújo, Jurandy do Nascimento Silva, Antônia Maria das Graças Lopes Citó, Alessandro de Lima, Ruth Raquel Soares de Farias, Gardenia C.G. Militão, Cláudia Pessoa, Raffaele Capasso, Nayana Bruna Nery Monção, Marcília Pinheiro da Costa, Paulo Michel Pinheiro Ferreira, Mônica Regina Silva de Araújo, Mariana Helena Chaves, Silva, J. D. N., Moncao, N. B. N., de Farias, R. R. S., Cito, A. M. D. G. L., Chaves, M. H., Araujo, M. R. S. D., Lima, D. J. B., Pessoa, C., Lima, A. D., Araujo, E. C. D. C., Militao, G. C. G., Costa, M. P. D., Capasso, R., and Ferreira, P. M. P.

Subjects
Flora, Health, Toxicology and Mutagenesis, Zoology, Biology, Toxicology, medicine.disease_cause, Ecotoxicology, 01 natural sciences, environmental toxicology, Antioxidants, medicine, Cytotoxic T cell, Humans, Cells, Cultured, Ecosystem, Methylene Chloride, Plants, Medicinal, 010405 organic chemistry, Cytotoxins, Plant Extracts, genotoxicity, Cell Cycle, Antineoplastic Agents, Phytogenic, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Oxidative Stress, cell cycle arrest, Environmental toxicology, antitumoral action, Genotoxicity, Brazil, DNA Damage
Abstract

Caatinga flora which are found in a poor Brazilian region contain a substantial number of endemic taxa with biomedical and social importance for regional communities. This study examined the antioxidant and cytotoxic potential of 35 samples (extracts/fractions) from 12 Caatinga species and determined the antiproliferative and genotoxic action of dichloromethane fraction from Mimosa caesalpiniifolia stem bark (DC-Mca) on human and vegetal cells. Samples were assessed for chemopreventive ability, toxic effects on Artemia salina shrimp as well as cytotoxicity on tumor cell lines and erythrocytes. DC-Mca was also tested with respect to antiproliferative and genotoxic effects upon normal leukocytes and meristematic cells from A. cepa roots. Some extracts reduced free radical levels >95% and 7 samples exhibited a lethal concentration (LC) 50

Published
2020

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