274 results on '"Miligi L"'
Search Results
2. Smoking and Hematolymphopoietic Malignancies
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Stagnaro, E., Ramazzotti, V., Crosignani, P., Fontana, A., Masala, G., Miligi, L., Nanni, O., Neri, M., Rodella, S., Costantini, A. Seniori, Tumino, R., Viganò, C., Vindigni, C., and Vineis, P.
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- 2001
3. Coffee consumption and risk of non-Hodgkin’s lymphoma: evidence from the Italian multicentre case–control study
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Parodi, Stefano, Merlo, Franco Domenico, Stagnaro, Emanuele, Crosignani, P., Fontana, A., Miligi, L., Masala, G., Nanni, O., Ramazzotti, V., Rodella, S., Costantini, A. Seniori, Tumino, R., Viganò, C., Vindigni, C., Vineis, P., and On behalf of the Working Group for the Epidemiology of Hematolymphopoietic Malignancies in Italy
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- 2017
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4. Occupational exposure to trichloroethylene and risk of non-Hodgkin lymphoma and its major subtypes: a pooled linterLlymph analysis
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Cocco, P, Vermeulen, R, Flore, V, Nonne, T, Campagna, M, Purdue, M, Blair, A, Monnereau, A, Orsi, L, Clavel, J, Becker, N, de Sanjosé, S, Foretova, L, Staines, A, Maynadié, M, Nieters, A, Miligi, L, Mannetje, A 't, Kricker, A, Brennan, P, Boffetta, P, Lan, Q, and Rothman, N
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- 2013
- Full Text
- View/download PDF
5. Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer
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Besson, C., Moore, A., Vajdic, C.M., de Sanjose, S., Camp, N.J., Smedby, K.E., Shanafelt, T.D., Morton, L.M., Brewer, J.D., Zablotska, L., Chung, C.C., Teras, L.R., Kleinstern, G., Monnereau, A., Kane, E., Benavente, Y., Purdue, M.P., Birmann, B.M., Link, B.K., Vermeulen, R.C.H., Spinelli, J.J., Albanes, D., Arslan, A.A., Miligi, L., Molina, T.J., Skibola, C.F., Cozen, W., Staines, A., Caporaso, N.E., Giles, G.G., Southey, M.C., Milne, R.L., Tinker, L.F., Severson, R.K., Melbye, M., Adami, H.-O., Glimelius, B., Bracci, P.M., Conde, L., Glenn, M., Curtin, K., Lan, Q., Zheng, T., Weinstein, S., Brooks-Wilson, A.R., Diver, W.R., Clavel, J., Vineis, P., Weiderpass, E., Becker, N., Boffetta, P., Brennan, P., Foretova, L., Maynadie, M., Weinberg, J.B., Sanna, S., Gambelunghe, A., Jackson, R.D., Hjalgrim, H., North, K.E., McKay, J., Offit, K., Vijai, J., Nieters, A., Engels, E.A., Chanock, S.J., Rothman, N., Cerhan, J.R., Slager, S.L., Han, J., Berndt, S.I., IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2
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0301 basic medicine ,Oncology ,medicine.medical_specialty ,Skin Neoplasms ,Epidemiology ,Chronic lymphocytic leukemia ,Single-nucleotide polymorphism ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,0302 clinical medicine ,Polygenic risk score ,immune system diseases ,Risk Factors ,Polymorphism (computer science) ,hemic and lymphatic diseases ,Internal medicine ,Pleiotropism ,Genetics ,medicine ,Genetic predisposition ,Humans ,Basal cell carcinoma ,neoplasms ,Pleiotropy ,business.industry ,General Medicine ,Odds ratio ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,NMSC ,030104 developmental biology ,Carcinoma, Basal Cell ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Skin cancer ,business ,CLL - Abstract
Background Epidemiological studies have demonstrated a positive association between chronic lymphocytic leukaemia (CLL) and non-melanoma skin cancer (NMSC). We hypothesized that shared genetic risk factors between CLL and NMSC could contribute to the association observed between these diseases. Methods We examined the association between (i) established NMSC susceptibility loci and CLL risk in a meta-analysis including 3100 CLL cases and 7667 controls and (ii) established CLL loci and NMSC risk in a study of 4242 basal cell carcinoma (BCC) cases, 825 squamous cell carcinoma (SCC) cases and 12802 controls. Polygenic risk scores (PRS) for CLL, BCC and SCC were constructed using established loci. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results Higher CLL-PRS was associated with increased BCC risk (OR4th-quartile-vs-1st-quartile = 1.13, 95% CI: 1.02–1.24, Ptrend = 0.009), even after removing the shared 6p25.3 locus. No association was observed with BCC-PRS and CLL risk (Ptrend = 0.68). These findings support a contributory role for CLL in BCC risk, but not for BCC in CLL risk. Increased CLL risk was observed with higher SCC-PRS (OR4th-quartile-vs-1st-quartile = 1.22, 95% CI: 1.08–1.38, Ptrend = 1.36 × 10–5), which was driven by shared genetic susceptibility at the 6p25.3 locus. Conclusion These findings highlight the role of pleiotropy regarding the pathogenesis of CLL and NMSC and shows that a single pleiotropic locus, 6p25.3, drives the observed association between genetic susceptibility to SCC and increased CLL risk. The study also provides evidence that genetic susceptibility for CLL increases BCC risk.
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- 2021
6. Wireless phone use in childhood and adolescence and neuroepithelial brain tumours: Results from the international MOBI-Kids study
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Castaño-Vinyals, G, Sadetzki, S, Vermeulen, R, Momoli, F, Kundi, M, Merletti, F, Maslanyj, M, Calderon, C, Wiart, J, Lee, A-K, Taki, M, Sim, M, Armstrong, B, Benke, G, Schattner, R, Hutter, H-P, Krewski, D, Mohipp, C, Ritvo, P, Spinelli, J, Lacour, B, Remen, T, Radon, K, Weinmann, T, Petridou, E Th, Moschovi, M, Pourtsidis, A, Oikonomou, K, Kanavidis, P, Bouka, E, Dikshit, R, Nagrani, R, Chetrit, A, Bruchim, R, Maule, M, Migliore, E, Filippini, G, Miligi, L, Mattioli, S, Kojimahara, N, Yamaguchi, N, Ha, M, Choi, K, Kromhout, H, Goedhart, G, 't Mannetje, A, Eng, A, Langer, C E, Alguacil, J, Aragonés, N, Morales-Suárez-Varela, M, Badia, F, Albert, A, Carretero, G, Cardis, E, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2
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Adult ,Male ,Adolescent ,Radio Waves ,Cell phones ,Socio-culturale ,Brain tumors ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Electromagnetic Fields ,Economica ,Environmental Science(all) ,Tumors cerebrals ,Humans ,GE1-350 ,Mobile phones ,030212 general & internal medicine ,Child ,Wireless phones ,Brain tumours ,Young people ,Extremely low frequency electromagnetic fields ,Radiofrequency radiation ,General Environmental Science ,Brain Neoplasms ,Ambientale ,Glioma ,3. Good health ,Environmental sciences ,Telèfon mòbil ,030220 oncology & carcinogenesis ,Case-Control Studies ,Cell Phone - Abstract
In recent decades, the possibility that use of mobile communicating devices, particularly wireless (mobile and cordless) phones, may increase brain tumour risk, has been a concern, particularly given the considerable increase in their use by young people. MOBI-Kids, a 14-country (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, the Netherlands, New Zealand, Spain) case-control study, was conducted to evaluate whether wireless phone use (and particularly resulting exposure to radiofrequency (RF) and extremely low frequency (ELF) electromagnetic fields (EMF)) increases risk of brain tumours in young people. Between 2010 and 2015, the study recruited 899 people with brain tumours aged 10 to 24 years old and 1,910 controls (operated for appendicitis) matched to the cases on date of diagnosis, study region and age. Participation rates were 72% for cases and 54% for controls. The mean ages of cases and controls were 16.5 and 16.6 years, respectively; 57% were males. The vast majority of study participants were wireless phones users, even in the youngest age group, and the study included substantial numbers of long-term (over 10 years) users: 22% overall, 51% in the 20-24-year-olds. Most tumours were of the neuroepithelial type (NBT; n = 671), mainly glioma. The odds ratios (OR) of NBT appeared to decrease with increasing time since start of use of wireless phones, cumulative number of calls and cumulative call time, particularly in the 15-19 years old age group. A decreasing trend in ORs was also observed with increasing estimated cumulative RF specific energy and ELF induced current density at the location of the tumour. Further analyses suggest that the large number of ORs below 1 in this study is unlikely to represent an unknown causal preventive effect of mobile phone exposure: they can be at least partially explained by differential recall by proxies and prodromal symptoms affecting phone use before diagnosis of the cases. We cannot rule out, however, residual confounding from sources we did not measure. Overall, our study provides no evidence of a causal association between wireless phone use and brain tumours in young people. However, the sources of bias summarised above prevent us from ruling out a small increased risk. Funding for the coordination of the MOBI-Kids study was obtained from the European Community's Seventh Framework Programme under grant agreements number 226873 and 603794, and from the Spanish Ministry of Science and Innovation (MINECO). In Spain, additional funding was obtained from the Spanish Health Research Fund (FIS) of the National Institute for Health Carlos III, and from the Junta de Andalucía, Consejería de Salud. Proyecto PI-0317-2010. ISGlobal also acknowledges support from the Spanish Ministry of Science, Innovation and Universities through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), support from the Generalitat de Catalunya through the CERCA Program and support from the Secretariat of Universities and Research of the Department of Business and Knowledge of the Generalitat of Catalonia through AGAUR (the Catalan Agency for Management of University and Research Grants) (Project 2017 SGR 1487). Australian participation in MOBI-Kids was supported by the Australian National Health and Medical Research Council with a five-year research grant (grant number: 546130). Austrian participation in MOBI-Kids was partly supported by a grant from the Ministry of Science. In Canada, participation in MOBI-Kids was supported by a university-industry partnership grant from the Canadian Institutes of Health Research (CIHR), reference number 110835, with the Canadian Wireless Telecommunications Association (CWTA) serving as the industrial partner. CWTA provides technical information on wireless telecommunications in Canada and facilitates access to billing records from Canadian network operators, but has no involvement in the design, conduct, analysis, or interpretation of the MOBI-KIDS study. French participation was also supported by the French National Agency for Sanitary Safety of Food, Environment and Labour (ANSES, contract FSRF2008-3), French National Cancer Institute (INCa), Pfizer Foundation and League against cancer. The German study centre received additional funding from the Federal Office for Radiation Protection (BfS) under grant number 3609S30010. In Greece, the study was partially supported by the Hellenic Society for Social Pediatrics and Health Promotion, ELKE (Special Account for Research Grants of the National and Kapodistrian University of Athens) and GGET (General Secretariat for Research and Technology). Mobi-Kids India was supported by Board of Research in Nuclear Sciences (BRNS, sanction no: 2013/38/01-BRNS).
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- 2022
7. Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure
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Magnani C., Silvestri S., Angelini A., Ranucci A., Azzolina D., Cena T., Chellini E., Merler E., Pavone V., Miligi L., Gorini G., Bressan V., Girardi P., Bauleo L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Mattioli S., Baldassarre A., Barone-Adesi F., Musti M., Mirabelli D., Pirastu R., Marinaccio A., Massari S., Ferrante D, Working Group, Ballarin MN, Brentisci C, Cortini B, Curti S, Gangemi M, Gioffrè F, Legittimo P, Mangone L, Marinelli F, Marinilli P, Panato C, Roncaglia F, Storchi C, Stura A, Vicentini M, Verdi S, Nannavecchia AM, Bisceglia L, Magnani C., Silvestri S., Angelini A., Ranucci A., Azzolina D., Cena T., Chellini E., Merler E., Pavone V., Miligi L., Gorini G., Bressan V., Girardi P., Bauleo L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Mattioli S., Baldassarre A., Barone-Adesi F., Musti M., Mirabelli D., Pirastu R., Marinaccio A., Massari S., Ferrante D, Working Group, Ballarin MN, Brentisci C, Cortini B, Curti S, Gangemi M, Gioffrè F, Legittimo P, Mangone L, Marinelli F, Marinilli P, Panato C, Roncaglia F, Storchi C, Stura A, Vicentini M, Verdi S, Nannavecchia AM, and Bisceglia L
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Risk ,Mesothelioma ,Lung Neoplasms ,Pleural Neoplasms ,Socio-culturale ,Asbesto ,Cohort Studies ,Cause of Death ,Occupational Exposure ,Asbestos ,Glassworks ,Rolling stock ,Shipyards ,Humans ,Industry ,Peritoneal Neoplasms ,Retrospective Studies ,Mineral Fibers ,Ovarian Neoplasms ,Construction Materials ,Ambientale ,Italy ,Urinary Bladder Neoplasms ,Asbestosis ,Glasswork ,Female - Abstract
Italy has been a large user of asbestos and asbestos containing materials until the 1992 ban. We present a pooled cohort study on long-term mortality in exposed workers.Pool of 43 Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding, glasswork, harbors, insulation and other industries). SMRs were computed by industrial sector for the 1970-2010 period, for the major causes, using reference rates by age, sex, region and calendar period.The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Asbestos exposure was estimated at the plant and period levels. Asbestos related mortality was significantly increased. All industrial sectors showed increased mortality from pleural malignancies, and most also from peritoneal and lung cancer and asbestosis, with exposure related trend. Increased mortality was also observed for ovarian cancer and for bladder cancer.The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. A large increase in mortality from asbestosis was observed.
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- 2020
8. Factors Affecting Asbestosis Mortality Among Asbestos-Cement Workers in Italy
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Girardi P., Merler E., Ferrante D., Silvestri S., Chellini E., Angelini A., Luberto F., Fedeli U., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Miligi L., Perticaroli P., Pettinari A., Cuccaro F., Nannavecchia A. M., Bisceglia L., Marinaccio A., Pavone V. L. M., Magnani C., Working Group, Ancona L., Baldassarre A., Brentisci C., Cortini B., Curti S., Gangemi M., Gorini G., Legittimo P., Marinelli F., Marinilli P., Bressan V., Mattioli S., Ranucci A., Romeo E., Scarnato C., Storchi C., Stura A., Verdi S., Girardi P., Merler E., Ferrante D., Silvestri S., Chellini E., Angelini A., Luberto F., Fedeli U., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Miligi L., Perticaroli P., Pettinari A., Cuccaro F., Nannavecchia A.M., Bisceglia L., Marinaccio A., Pavone V.L.M., Magnani C., Working Group, Ancona L., Baldassarre A., Brentisci C., Cortini B., Curti S., Gangemi M., Gorini G., Legittimo P., Marinelli F., Marinilli P., Bressan V., Mattioli S., Ranucci A., Romeo E., Scarnato C., Storchi C., Stura A., and Verdi S.
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Male ,Asbestos, Serpentine ,Asbestosis ,Cumulative Exposure ,Asbesto ,cohort mortality study ,medicine.disease_cause ,Asbestos ,Settore MED/01 - Statistica Medica ,NO ,03 medical and health sciences ,asbestos exposure ,0302 clinical medicine ,Occupational Exposure ,Chrysotile ,Medicine ,Humans ,030212 general & internal medicine ,Asbestos-related diseases ,Asbestos-related disease ,business.industry ,Asbestos exposure ,Cohort mortality study ,Retrospective assessment ,asbestos-related diseases ,asbestosis ,retrospective assessment ,Public Health, Environmental and Occupational Health ,Asbestosi ,Middle Aged ,medicine.disease ,030210 environmental & occupational health ,Asbestos cement ,Cohort effect ,Italy ,Cohort ,Female ,business ,Settore SECS-S/01 - Statistica ,Demography ,Human - Abstract
Objectives This study was performed with the aim of investigating the temporal patterns and determinants associated with mortality from asbestosis among 21 cohorts of Asbestos-Cement (AC) workers who were heavily exposed to asbestos fibres. Methods Mortality for asbestosis was analysed for a cohort of 13 076 Italian AC workers (18.1% women). Individual cumulative asbestos exposure index was calculated by factory and period of work weighting by the different composition of asbestos used (crocidolite, amosite, and chrysotile). Two different approaches to analysis, based on Standardized Mortality Ratios (SMRs) and Age-Period-Cohort (APC) models were applied. Results Among the considered AC facilities, asbestos exposure was extremely high until the end of the 1970s and, due to the long latency, a peak of asbestosis mortality was observed after the 1990s. Mortality for asbestosis reached extremely high SMR values [SMR: males 508, 95% confidence interval (CI): 446–563; females 1027, 95% CI: 771–1336]. SMR increased steeply with the increasing values of cumulative asbestos exposure and with Time Since the First Exposure. APC analysis reported a clear age effect with a mortality peak at 75–80 years; the mortality for asbestosis increased in the last three quintiles of the cumulative exposure; calendar period did not have a significant temporal component while the cohort effect disappeared if we included in the model the cumulative exposure to asbestos. Conclusions Among heaviest exposed workers, mortality risk for asbestosis began to increase before 50 years of age. Mortality for asbestosis was mainly determined by cumulative exposure to asbestos.
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- 2019
9. Delayed Infection, Family Size and Malignant Lymphomas
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Vineis, P., Miligi, L., Crosignani, P., Fontana, A., Masala, G., Nanni, O., Ramazzotti, V., Rodella, S., Stagnaro, E., Tumino, R., Viganò, C., Vindigni, C., and Costantini, A. Seniori
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- 2000
10. Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy
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Luberto F., Ferrante D., Silvestri S., Angelini A., Cuccaro F., Nannavecchia A. M., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Chellini E., Miligi L., Perticaroli P., Pettinari A., Bressan V., Merler E., Girardi P., Bisceglia L., Marinaccio A., Massari S., Magnani C., Working group, Curti S., Mattioli S., Luberto F., Ferrante D., Silvestri S., Angelini A., Cuccaro F., Nannavecchia A.M., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Chellini E., Miligi L., Perticaroli P., Pettinari A., Bressan V., Merler E., Girardi P., Bisceglia L., Marinaccio A., Massari S., Magnani C., Working group, Curti S., and Mattioli S.
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Male ,Mesothelioma ,Asbestos, Asbestos-cement, Dose response relationship, Mesothelioma, Lung cancer, Ovarian Cancer, Epidemiology ,Time Factors ,Epidemiology ,Health, Toxicology and Mutagenesis ,Asbestosis ,Physiology ,Cumulative Exposure ,medicine.disease_cause ,Cohort Studies ,Neoplasms ,Chrysotile ,Asbestos-related diseases ,0303 health sciences ,lcsh:Public aspects of medicine ,Middle Aged ,Asbestos-cement ,Asbestos cement ,Ovarian Cancer ,Italy ,Dose response relationship ,lcsh:Industrial medicine. Industrial hygiene ,Female ,Lung cancer ,Settore SECS-S/01 - Statistica ,Adult ,Asbesto ,Asbestos ,Settore MED/01 - Statistica Medica ,NO ,03 medical and health sciences ,lcsh:RC963-969 ,Young Adult ,Sex Factors ,Occupational Exposure ,medicine ,Humans ,business.industry ,Research ,Public Health, Environmental and Occupational Health ,030311 toxicology ,lcsh:RA1-1270 ,medicine.disease ,business - Abstract
Background Despite the available information on cancer risk, asbestos is used in large areas in the world, mostly in the production of asbestos cement. Moreover, questions are raised regarding the shape of the dose response relation, the relation with time since exposure and the association with neoplasms in various organs. We conducted a study on the relationship between cumulative asbestos exposure and mortality from asbestos related diseases in a large Italian pool of 21 cohorts of asbestos-cement workers with protracted exposure to both chrysotile and amphibole asbestos. Methods The cohort included 13,076 workers, 81.9% men and 18.1% women, working in 21 Italian asbestos-cement factories, with over 40 years of observation. Exposure was estimated by plant and period, and weighted for the type of asbestos used. Data were analysed with consideration of cause of death, cumulative exposure and time since first exposure (TSFE), and by gender. SMRs were computed using reference rates by region, gender and calendar time. Poisson regression models including cubic splines were used to analyse the effect of cumulative exposure to asbestos and TSFE on mortality for asbestos-related diseases. 95% Confidence Intervals (CI) were computed according to the Poisson distribution. Results Mortality was significantly increased for ‘All Causes’ and ‘All Malignant Neoplasm (MN)’, in both genders. Considering asbestos related diseases (ARDs), statistically significant excesses were observed for MN of peritoneum (SMR: men 14.19; women 15.14), pleura (SMR: 22.35 and 48.10), lung (SMR: 1.67 and 1.67), ovary (in the highest exposure class SMR 2.45), and asbestosis (SMR: 507 and 1023). Mortality for ARDs, in particular pleural and peritoneal malignancies, lung cancer, ovarian cancer and asbestosis increased monotonically with cumulative exposure. Pleural MN mortality increased progressively in the first 40 years of TSFE, then reached a plateau, while peritoneal MN showed a continuous increase. The trend of lung cancer SMRs also showed a flattening after 40 years of TSFE. Attributable proportions for pleural, peritoneal, and lung MN were respectively 96, 93 and 40%. Conclusions Mortality for ARDs was associated with cumulative exposure to asbestos. Risk of death from pleural MN did not increase indefinitely with TSFE but eventually reached a plateau, consistently with reports from other recent studies. Electronic supplementary material The online version of this article (10.1186/s12940-019-0510-6) contains supplementary material, which is available to authorized users.
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- 2019
11. Role of asbestos clearance in explaining long-term risk of pleural and peritoneal cancer: a pooled analysis of cohort studies
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Barone-Adesi F., Ferrante D., Chellini E., Merler E., Pavone V., Silvestri S., Miligi L., Gorini G., Bressan V., Girardi P., Ancona L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Curti S., Baldassarre A., Cena T., Angelini A., Marinaccio A., Mirabelli D., Musti M., Pirastu R., Ranucci A., Magnani C., Working Group, Mattioli S., Barone-Adesi F., Ferrante D., Chellini E., Merler E., Pavone V., Silvestri S., Miligi L., Gorini G., Bressan V., Girardi P., Ancona L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Curti S., Baldassarre A., Cena T., Angelini A., Marinaccio A., Mirabelli D., Musti M., Pirastu R., Ranucci A., Magnani C., Working Group, and Mattioli S.
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Oncology ,Adult ,Male ,medicine.medical_specialty ,Time Factors ,Time Factor ,Adolescent ,Pleural Neoplasms ,asbestos ,epidemiology ,mesothelioma ,Asbesto ,medicine.disease_cause ,Asbestos ,Settore MED/01 - Statistica Medica ,NO ,03 medical and health sciences ,Peritoneal Neoplasm ,Young Adult ,0302 clinical medicine ,Internal medicine ,Occupational Exposure ,Epidemiology ,medicine ,Humans ,Pleural Neoplasm ,Mesothelioma ,Young adult ,Peritoneal Neoplasms ,business.industry ,Public Health, Environmental and Occupational Health ,Cancer ,asbestos, epidemiology, mesothelioma, Adolescent, Adult, Italy ,Middle Aged ,Models, Theoretical ,medicine.disease ,030210 environmental & occupational health ,Occupational Disease ,Occupational Diseases ,asbestos, epidemiology, mesothelioma ,Italy ,030220 oncology & carcinogenesis ,Female ,business ,Human ,Cohort study - Abstract
ObjectivesModels based on the multistage theory of cancer predict that rates of malignant mesothelioma continuously increase with time since first exposure (TSFE) to asbestos, even after the end of external exposure. However, recent epidemiological studies suggest that mesothelioma rates level off many years after first exposure to asbestos. A gradual clearance of asbestos from the lungs has been suggested as a possible explanation for this phenomenon. We analysed long-term trends of pleural and peritoneal cancer mortality in subjects exposed to asbestos to evaluate whether such trends were consistent with the clearance hypothesis.MethodsWe used data from a pool of 43 Italian asbestos cohorts (51 801 subjects). The role of asbestos clearance was explored using the traditional mesothelioma multistage model, generalised to include a term representing elimination of fibres over time.ResultsRates of pleural cancer increased until 40 years of TSFE, but remained stable thereafter. On the other hand, we observed a monotonic increase of peritoneal cancer with TSFE. The model taking into account asbestos clearance fitted the data better than the traditional one for pleural (p=0.004) but not for peritoneal (p=0.09) cancer.ConclusionsRates of pleural cancer do not increase indefinitely after the exposure to asbestos, but eventually reach a plateau. This trend is well described by a model accounting for a gradual elimination of the asbestos fibres. These results are relevant for the prediction of future rates of mesothelioma and in asbestos litigations.
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- 2019
12. Occupational exposure to trichloroethylene and risk of non-Hodgkin lymphoma and its major subtypes: a pooled IinterLlymph analysis
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Cocco, P, Vermeulen, R, Flore, V, Nonne, T, Campagna, M, Purdue, M, Blair, A, Monnereau, A, Orsi, L, Clavel, J, Becker, N, de Sanjosé, S, Foretova, L, Staines, A, Maynadié, M, Nieters, A, Miligi, L, ‘t Mannetje, A, Kricker, A, Brennan, P, Boffetta, P, Lan, Q, and Rothman, N
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- 2013
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13. Genetically Determined Height and Risk of Non-hodgkin Lymphoma
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Moore, A., Kane, E., Panagiotou, O.A., Teras, L.R., Monnereau, A., Wong Doo, N., Machiela, M.J., Skibola, C.F., Slager, S.L., Salles, G., Camp, N.J., Bracci, P.M., Nieters, A., Vermeulen, R.C.H., Vijai, J., Smedby, K.E., Vajdic, C.M., Cozen, W., Spinelli, J.J., Hjalgrim, H., Giles, G.G., Link, B.K., Clavel, J., Arslan, A.A., Purdue, M.P., Tinker, L.F., Albanes, D., Ferri, G.M., Habermann, T.M., Adami, H.-O., Becker, N., Benavente, Y., Bisanzi, S., Boffetta, P., Brennan, P., Brooks-Wilson, A.R., Canzian, F., Conde, L., Cox, D.G., Curtin, K., Foretova, L., Gapstur, S.M., Ghesquières, H., Glenn, M., Glimelius, B., Jackson, R.D., Lan, Q., Liebow, M., Maynadie, M., McKay, J., Melbye, M., Miligi, L., Milne, R.L., Molina, T.J., Morton, L.M., North, K.E., Offit, K., Padoan, M., Piro, S., Ravichandran, V., Riboli, E., de Sanjose, S., Severson, R.K., Southey, M.C., Staines, A., Stewart, C., Travis, R.C., Weiderpass, E., Weinstein, S., Zheng, T., Chanock, S.J., Chatterjee, N., Rothman, N., Birmann, B.M., Cerhan, J.R., Berndt, S.I., IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2
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follicular lymphoma ,non-Hodgkin lymphoma ,polygenic risk score ,diffuse large B-celllymphoma ,chronic lymphocytic leukemia ,genetics ,marginal zone lymphoma ,height - Abstract
Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
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- 2020
14. Occupational Pesticide Use and Risk of Non-Hodgkin Lymphoma
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De Roos, A.J., primary, Schinasi, L.H., additional, Miligi, L., additional, Spinelli, J.J., additional, Cerhan, J.R., additional, Fritschi, L., additional, Hofmann, J.N., additional, Monnereau, A., additional, Baris, D., additional, Benevente, Y., additional, Benke, G., additional, Clavel, J., additional, de Sanjose, S., additional, Huynh, T., additional, Piro, S., additional, Slager, S.L., additional, Vajdic, C., additional, Wang, S.S., additional, Zhang, Y., additional, tMannetje, A., additional, Bernstein, L., additional, and Cocco, P., additional
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- 2020
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15. Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)
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Kamper-Jørgensen, M., Rostgaard, K., Glaser, S. L., Zahm, S. H., Cozen, W., Smedby, K. E., Sanjosé, S., Chang, E. T., Zheng, T., La Vecchia, C., Serraino, D., Monnereau, A., Kane, E. V., Miligi, L., Vineis, P., Spinelli, J. J., McLaughlin, J. R., Pahwa, P., Dosman, J. A., Vornanen, M., Foretova, L., Maynadie, M., Staines, A., Becker, N., Nieters, A., Brennan, P., Boffetta, P., Cocco, P., and Hjalgrim, H.
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- 2013
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16. Cigarette smoking and alcohol consumption as determinants of survival in non-Hodgkin's lymphoma: a population-based study
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Battaglioli, T., Gorini, G., Costantini, A. Seniori, Crosignani, P., Miligi, L., Nanni, O., Stagnaro, E., Tumino, R., and Vineis, P.
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- 2006
- Full Text
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17. Risk of nasopharyngeal cancer in productive sectors and formaldehyde exposure in bakeries industry
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Miligi, L, primary, Massari, S, additional, Paredes Alpaca, R I, additional, Piro, S, additional, Airoldi, C, additional, Ranucci, A, additional, Romeo, E, additional, Scondotto, S, additional, Cenni, A, additional, and Aprea, M C, additional
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- 2020
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18. Cancer cluster and citizen alarms: epidemiological and statistical approaches
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Miligi, L, primary, Stoppa, G, additional, Piro, S, additional, Caldarella, A, additional, Intrieri, T, additional, Mannesci, G, additional, Ferrari, C, additional, Biggeri, A, additional, and Catelan, D, additional
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- 2020
- Full Text
- View/download PDF
19. AMIANTO
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Comba, Pietro, Minoia, C, Carnevale, F, Marsili, Daniela, Ferrante, D., Chellini, E., Merler, E., Pavone, V., Silvestri, S., Miligi, L., Gorini, G., Bressan, V., Girardi, P., Ancona, L., Romeo, E., Luberto, F., Sala, O., Scarnato, C., Menegozzo, S., Oddone, E., Tunesi, S., Perticaroli, P., Pettinari, A., Cuccaro, F., Mattioli, S., Baldassarre, A., Angelini, A., Barone Adesi, F., Cena, T., Legittimo, P., Marinaccio, A., Mirabelli, D., Musti, M., Pirastu, R., and Ranucci, A. e Magnani C.
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- 2019
20. AMIANTO
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Comba, P, Minoia, C, Carnevale, F, Marsili, D, Ferrante, D., Chellini, E., Merler, E., Pavone, V., Silvestri, S., Miligi, L., Gorini, G., Bressan, V., Girardi, P., Ancona, L., Romeo, E., Luberto, F., Sala, O., Scarnato, C., Menegozzo, S., Oddone, E., Tunesi, S., Perticaroli, P., Pettinari, A., Cuccaro, F., Mattioli, S., Baldassarre, A., Angelini, A., Barone Adesi, F., Cena, T., Legittimo, P., Marinaccio, A., Mirabelli, D., Musti, M., Pirastu, R., and Ranucci, A. e Magnani C.
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Settore MED/01 - Statistica Medica - Published
- 2019
21. Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: Findings from the Childhood Leukaemia International Consortium (CLIC)
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Talibov, M. Olsson, A. Bailey, H. Erdmann, F. Metayer, C. Magnani, C. Petridou, E. Auvinen, A. Spector, L. Clavel, J. Roman, E. Dockerty, J. Nikkilä, A. Lohi, O. Kang, A. Psaltopoulou, T. Miligi, L. Vila, J. Cardis, E. Schüz, J.
- Abstract
Objectives Previously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium. Methods We pooled 11 case-control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated by linking jobs to an ELF-MF job-exposure matrix (JEM). Logistic regression models were used to estimate ORs and 95% CIs in pooled analyses and meta-analyses. Results ORs from pooled analyses for paternal ELF-MF exposure >0.2 microtesla (μT) at conception were 1.04 (95% CI 0.95 to 1.13) for ALL and 1.06 (95% CI 0.87 to 1.29) for AML, compared with ≤0.2 μT. Corresponding ORs for maternal ELF-MF exposure during pregnancy were 1.00 (95% CI 0.89 to 1.12) for ALL and 0.85 (95% CI 0.61 to 1.16) for AML. No trends of increasing ORs with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses. Conclusions In this large international dataset applying a comprehensive quantitative JEM, we did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia. © © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
- Published
- 2019
22. Alcohol consumption and risk of Hodgkinʼs lymphoma and multiple myeloma: a multicentre case–control study
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Gorini, G., Stagnaro, E., Fontana, V., Miligi, L., Ramazzotti, V., Amadori, D., Rodella, S., Tumino, R., Crosignani, P., Vindigni, C., Fontana, A., Vineis, P., and Costantini, A. Seniori
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- 2007
23. Cytogenetic biomonitoring of styrene-exposed plastic boat builders
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Artuso, M., Angotzi, G., Bonassi, S., Bonatti, S., De Ferrari, M., Gargano, D., Lastrucci, L., Miligi, L., Sbrana, C., and Abbondandolo, A.
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- 1995
- Full Text
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24. Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study
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Miligi L, Benvenuti A, Salvan A, Tozzi GA, Ranucci A, Legittimo P, Bisanti L, Zambon P, Cannizzaro S, Kirchmayer U, Cocco P, Celentano E, Assennato G, Merlo DF, Mosciatti P, Minelli L, Cuttini M, Torregrossa V, Lagorio S, Haupt R, Risica S, Polichetti A, SETIL Working Group, Magnani C., MATTIOLI, STEFANO, RONDELLI, ROBERTO, Miligi L, Benvenuti A, Mattioli S, Salvan A, Tozzi GA, Ranucci A, Legittimo P, Rondelli R, Bisanti L, Zambon P, Cannizzaro S, Kirchmayer U, Cocco P, Celentano E, Assennato G, Merlo DF, Mosciatti P, Minelli L, Cuttini M, Torregrossa V, Lagorio S, Haupt R, Risica S, Polichetti A, SETIL Working Group, Magnani C., Miligi, L., Benvenuti, A., Mattioli, S., Salvan, A., Tozzi, G., Ranucci, A., Legittimo, P., Rondelli, R., Bisanti, L., Zambon, P., Cannizzaro, S., Kirchmayer, U., Cocco, P., Celentano, E., Assennato, G., Merlo, D., Mosciatti, P., Minelli, L., Cuttini, M., Torregrossa, V., Lagorio, S., Haupt, R., Risica, S., Polichetti, A., and Magnani, C.
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Male ,Toxicology ,Economica ,Pregnancy ,hemic and lymphatic diseases ,Epidemiology ,Child ,Multivariate Analysi ,parental exposure ,Incidence ,Lymphoma, Non-Hodgkin ,Incidence (epidemiology) ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Occupational exposure ,Epidemiologic Studie ,Italy ,Maternal Exposure ,Chemical Industry ,Child, Preschool ,Prenatal Exposure Delayed Effects ,Solvent ,Paternal Exposure ,Female ,Survival Analysi ,HYDROCARBONS ,Case-Control Studie ,Risk assessment ,Human ,medicine.medical_specialty ,Logistic Model ,Adolescent ,Socio-culturale ,Context (language use) ,Risk Assessment ,Prenatal Exposure Delayed Effect ,Hazardous Substances ,Age Distribution ,Environmental health ,medicine ,Humans ,Sex Distribution ,Survival analysis ,ACUTE LYMPHOBLASTIC-LEUKEMIA ,business.industry ,Public Health, Environmental and Occupational Health ,Case-control study ,Ambientale ,medicine.disease ,Survival Analysis ,Non-Hodgkin's lymphoma ,Epidemiologic Studies ,Logistic Models ,solvents ,Hazardous Substance ,Case-Control Studies ,Multivariate Analysis ,business - Abstract
AIM: In the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin's Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures. METHODS: All cases of childhood leukaemia and non-Hodgkin's lymphoma (NHL) in children aged 0-10 years were identified. Controls were chosen at random from the local population in each region. Parents were interviewed using a structured questionnaire. The collected data were blindly reviewed by expert industrial hygienists in order to estimate exposure to a list of agents. Statistical analyses were performed for each agent using unconditional multivariable logistic regression models, taking into account timing of exposure. RESULTS: 683 cases of acute childhood leukaemia, 97 cases of NHL and 1044 controls were identified. Increased risk of childhood leukaemia was found for maternal exposure to aliphatic (OR 4.3) or aromatic hydrocarbons (OR 3.8) in the preconception period, and for paternal exposure to diesel exhaust (OR 1.4), lead exposure (OR 1.7) and mineral oils (OR 1.4)[corrected]. Risk of NHL appeared to be related to paternal exposure to oxygenated solvents (OR 2.5) and petrol exhaust (OR 2.2). CONCLUSIONS: We found increased risk for childhood leukaemia associated with maternal occupational exposure to aromatic and aliphatic hydrocarbons, particularly in the preconception period; increased risks were also observed for paternal exposure to diesel exhaust fumes, mineral oils and lead. The risk of NHL appeared to be related to paternal exposure to oxygenated solvent and petrol exhausts.
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- 2013
25. [SENTIERI - Epidemiological study of residents in national priority contaminated sites: incidence of mesothelioma]
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Binazzi, A, Bruno, C, Comba, P, Conti, S, Corfiati, M, Fazzo, L, Manno, V, Marinaccio, A, Menegozzo, S, Minelli, G, Pasetto, R, Pirastu, R, Zona, A, ANGELILLO, Italo Francesco, Canessa, Pa, Cauzillo, G, Cavone, D, Chellini, E, Cocchioni, M, De Michieli, P, Forastiere, F, Davoli, M, Di Giammarco, A, Gennaro, V, Giaimo, M, Gioffrè, F, Mangone, L, Mazzoleni, G, Mensi, C, Merler, E, Merletti, F, Merseburger, A, Miligi, L, Mirabelli, D, Musti, M, Negro, C, Nicita, C, Pascucci, C, Riboldi, L, Romanelli, A, Schallemberg, G, Stracci, F, Trafficante, L, Tumino, R., Binazzi, A, Bruno, C, Comba, P, Conti, S, Corfiati, M, Fazzo, L, Manno, V, Marinaccio, A, Menegozzo, S, Minelli, G, Pasetto, R, Pirastu, R, Zona, A, Angelillo, Italo Francesco, Canessa, Pa, Cauzillo, G, Cavone, D, Chellini, E, Cocchioni, M, De Michieli, P, Forastiere, F, Davoli, M, Di Giammarco, A, Gennaro, V, Giaimo, M, Gioffrè, F, Mangone, L, Mazzoleni, G, Mensi, C, Merler, E, Merletti, F, Merseburger, A, Miligi, L, Mirabelli, D, Musti, M, Negro, C, Nicita, C, Pascucci, C, Riboldi, L, Romanelli, A, Schallemberg, G, Stracci, F, Trafficante, L, and Tumino, R.
- Abstract
The purpose of SENTIERI-ReNaM Project is to describe mesothelioma incidence in the Italian National Priority Contaminated Sites (NPCSs). The present report deals with 39 NPCSs (20 in Northern Italy, 8 in Central Italy and 11 in Southern Italy). Asbestos is specifically mentioned in the regulatory acts of recognition for 10 NPCSs and it is the only agent that has determined environmental contamination in 3 of them (Casale Monferrato, Broni, and Bari). The timeframe of the study is 2000-2011 for 34 out of 39 sites. The corresponding reference periods for the sites of Latium, Campania, Umbria, and Bolzano Province are, respectively, 2001-2011, 2005-2011, and 2006-2011. Standardized Incidence Ratios (SIRs) for mesothelioma, with their corresponding 90% Confidence Intervals, have been estimated for all sites. The interpretation of the study findings has been based on anamnestic information made available by the Italian National Mesothelioma Registry (ReNaM), and completed thanks to knowledge derived from the international scientific literature. In men, mesothelioma incidence has shown excesses in 27/39 sites and defects in the remaining 12; in women, excesses have been reported in 20 sites, defects in 15, and no cases have been detected in the remaining 4 sites. The highest annual incidence rates have been observed in the sites characterized only by the presence of asbestos- cement factories (Broni and Casale Monferrato): respectively, 98.0 and 68.6 per 100,000 per year in men, 72.1 and 45.8 in women. Besides these two sites, the highest rates have been observed in the sites with naval shipyards: 13.2 in men and 2.5 in women. Excesses of mesothelioma incidence have been confirmed (with respect to previous observations) in the sites of Broni, Casale Monferrato, Balangero, and in the coastal areas of Trieste, La Spezia, Venice, and Leghorn. Balangero has been the major European chrysotile quarry, while the other sites are characterized by the presence of naval shipyards with demonstrated use of asbestos before it was banned in 1992. An excess of mesothelioma incidence has also been confirmed in the site of Biancavilla, characterized by the presence of the fluoro-edenite fibrous amphibole, classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC). An increased incidence of mesothelioma was also observed in the areas where no direct use of asbestos had previously been documented, like Cengio and Saliceto (chemical industry), Falconara on Sea (oil refinery), and Litorale Domizio Flegreo and Agro Aversano (a large area including multiple hazardous waste dumping sites). These findings show that a relevant proportion of Italian mesothelioma cases is concentrated in NPCSs. About 1,500 extra cases of mesothelioma have been estimated in the overall series of 39 sites (2000-2011), corresponding to 125 extra cases per year. The excess has concerned the sites with manufacture of asbestos-cement products, but also the areas with asbestos quarries, naval shipyards, illegal hazardous waste dumping sites with asbestos-containing materials, petrochemical industries, refineries and steel plants. In some sites, particularly Casale Monferrato and Broni, analytical epidemiological studies have shown the causal role of not only occupational, but also environmental exposures, with special reference to paving of gardens and courtyards with asbestos-cement industry by-products. The main novelty generated by the collaborative SENTIERI-ReNaM Project concerns the detection of significant mesothelioma excesses not only in sites where asbestos is explicitly reported as a source of contamination, but also in a number of areas defined "of national interest" for environmental cleanup due to other sources of pollution. This confirms that the range of economic activities and working and living environments affected by asbestos exposure is very wide and it is not restricted to the industrial sectors characterized by the direct use of this material.
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- 2016
26. SENTIERI-ReNaM: Valutazione globale del carico di mesotelioma
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Binazzi A, GdL SENTIERI-ReNaM., Bruno, C, Comba, PAOLO GIOVANNI, Conti, S, Corfiati, M, Fazzo, L, Manno, V, Marinaccio, A, Menegozzo, S, Minelli, Giuditta, Pasetto, R, Pirastu, R, Zona, A, Angelillo, I, Canessa, Pa, Cauzillo, G, Cavone, D, Chellini, E, Cocchioni, M, De Michieli, P, Forastiere, F, Davoli, M, Di Giammarco, A, Gennaro, V, Giaimo, M, Gioffrè, F, Mangone, L, Mazzoleni, G, Mensi, C, Merler, E, Merletti, F, Merseburger, A, Miligi, L, Mirabelli, D, Musti, M, Negro, C, Nicita, C, Pascucci, C, Riboldi, Lorenzo, Romanelli, A, Schallemberg, G, Stracci, F, Trafficante, Luigi Alberto, and Tumino, R.
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Mesothelioma ,Male ,Risk ,Epidemiology ,Incidence ,Asbestos ,Burden of illness ,Italy ,National Priority Contaminated Sites - NPCSs ,Carcinogens, Environmental ,Confidence Intervals ,Female ,Health Surveys ,Humans ,Industry ,Occupational Exposure ,Registries ,Environmental Exposure ,Environmental Pollution ,Hazardous Waste Sites ,Public Health, Environmental and Occupational Health ,Environmental and Occupational Health ,Environmental ,Carcinogens ,Public Health - Published
- 2017
27. Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukemia
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Law, PJ, Berndt, SI, Speedy, HE, Camp, NJ, Sava, GP, Skibola, CF, Holroyd, A, Joseph, V, Sunter, NJ, Nieters, A, Bea, S, Monnereau, A, Martin-Garcia, D, Goldin, LR, Clot, G, Teras, LR, Quintela, I, Birmann, BM, Jayne, S, Cozen, W, Majid, A, Smedby, KE, Dearden, C, Brooks-Wilson, AR, Hall, AG, Purdue, MP, Mainou-Fowler, T, Vajdic, CM, Jackson, GH, Cocco, P, Marr, H, Zhang, Y, Zheng, T, Giles, GG, Lawrence, C, Call, TG, Liebow, M, Melbye, M, Glimelius, B, Mansouri, L, Glenn, M, Curtin, K, Diver, WR, Link, BK, Conde, L, Bracci, PM, Holly, EA, Jackson, RD, Tinker, LF, Benavente, Y, Boffetta, P, Brennan, P, Maynadie, M, McKay, J, Albanes, D, Weinstein, S, Wang, Z, Caporaso, NE, Morton, LM, Severson, RK, Riboli, E, Vineis, P, Vermeulen, RCH, Southey, MC, Milne, RL, Clavel, J, Topka, S, Spinelli, JJ, Kraft, P, Grazia Ennas, M, Summerfield, G, Ferri, GM, Harris, RJ, Miligi, L, Pettitt, AR, North, KE, Allsup, DJ, Fraumeni, JF, Bailey, JR, Offit, K, Pratt, G, Hjalgrim, H, Pepper, C, Chanock, SJ, Fegan, C, Rosenquist, R, De Sanjose, S, Carracedo, A, Dyer, MJS, Catovsky, D, Campo, E, Cerhan, JR, Allan, JM, Rothman, N, Houlston, R, and Slager, S
- Subjects
RISK ,CHROMATIN ,Science & Technology ,LOCI ,VARIANTS ,DISEASE ,Multidisciplinary Sciences ,TRANSCRIPTION FACTORS ,MD Multidisciplinary ,IMPUTATION ,Science & Technology - Other Topics ,BREAST-CANCER ,COMMON VARIATION ,METAANALYSIS - Abstract
Several chronic lymphocytic leukemia (CLL) susceptibility loci have been reported, however much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1000 Genomes and UK10K data, totaling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P = 5.04x10-13), 1q42.13 (rs41271473, P = 1.06x10-10), 4q24 (rs71597109, P = 1.37x10-10), 4q35.1 (rs57214277, P = 3.69x10-8), 6p21.31 (rs3800461, P = 1.97x10-8), 11q23.2 (rs61904987, P = 2.64x10-11), 18q21.1 (rs1036935, P = 3.27x10-8), 19p13.3 (rs7254272, P = 4.67x10-8) and 22q13.33 (rs140522, P = 2.70x10-9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for key determinants of B-cell development and immune response.
- Published
- 2016
28. Air pollution and childhood leukaemia: a nationwide case-control study in Italy
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Badaloni, C., Ranucci, A., Cesaroni, G., Zanini, G., Vienneau, D., Al Aidrous, F., De Hoogh, K., Magnani, C., Forastiere, F., Mattioli, Stefano, Miligi, L., Rondelli, R., Salvan, A., Masera, G., Rizzari, C., Bisanti, L., Zambon, P., Greco, A., Cannizzaro, S., Gafa, L., Luzzatto, L. L., Benvenuti, A., Michelozzi, P., Kirchmayer, U., Cocco, P., Galassi, C., Celentano, E., Guarino, E., Assennato, G., de Nichilo, G., Merlo, D. F., Bocchini, V., Mosciatti, P., Minelli, L., Chiavarini, M., Cuttini, M., Casotto, V., Torregrossa, M. V., Valenti, R. M., Haupt, R., Lagorio, S., Risica, S., Polichetti, A., Bochicchio, F., Nuccetelli, C., Biddau, P., Arico, M., De Salvo, G. L., Locatelli, F., Pession, Andrea, Varotto, S., Poggi, V., Massaglia, P., Monetti, D., Targhetta, R., Bernini, G., Pannelli, F., Sampietro, G., Schiliro, G., Pulsoni, A., Badaloni, C., Ranucci, A., Cesaroni, G., Zanini, G., Vienneau, D., Al-Aidrous, F., De Hoogh, K., Magnani, C., Forastiere, F., C. Badaloni, A. Ranucci, G. Cesaroni, G. Zanini, D. Vienneau, F. Al-Aidrou, K. De Hoogh, C. Magnani, F. Forastiere, S. Mattioli, L. Miligi, R. Rondelli, A. Salvan, G. Masera, C. Rizzari, L. Bisanti, P. Zambon, A. Greco, S. Cannizzaro, L. Gafa, L. L. Luzzatto, A. Benvenuti, P. Michelozzi, U. Kirchmayer, P. Cocco, C. Galassi, E. Celentano, E. Guarino, G. Assennato, G. de Nichilo, D. F. Merlo, V. Bocchini, P. Mosciatti, L. Minelli, M. Chiavarini, M. Cuttini, V. Casotto, M. V. Torregrossa, R. M. Valenti, R. Haupt, S. Lagorio, S. Risica, A. Polichetti, F. Bochicchio, C. Nuccetelli, P. Biddau, M. Arico, G. L. De Salvo, F. Locatelli, A. Pession, S. Varotto, V. Poggi, P. Massaglia, D. Monetti, R. Targhetta, G. Bernini, F. Pannelli, G. Sampietro, G. Schiliro, and A. Pulsoni
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Male ,Pediatrics ,Air pollution ,NO2 ,Land use Regression Model ,Logistic regression ,medicine.disease_cause ,Economica ,Residence Characteristics ,USE REGRESSION-MODELS ,Medicine ,Child ,Children ,Vehicle Emissions ,General Environmental Science ,USE REGRESSION-MODELS, RESIDENTIAL TRAFFIC DENSITY, MAGNETIC-FIELDS, POOLED ANALYSIS, RISK-FACTOR, CANCER, EXPOSURE, CHILDREN, NO2, ASSOCIATION ,Leukemia ,Incidence ,Incidence (epidemiology) ,ASSOCIATION ,CANCER ,Childhood leukaemia ,Italy ,Child, Preschool ,Female ,Case-Control Studie ,Human ,medicine.medical_specialty ,Socio-culturale ,MAGNETIC-FIELDS ,POOLED ANALYSIS ,RISK-FACTOR ,Air Pollution ,Occupational Exposure ,Environmental health ,Traffic Indicator ,Humans ,EXPOSURE ,RESIDENTIAL TRAFFIC DENSITY ,Exposure assessment ,Vehicle Emission ,business.industry ,Public Health, Environmental and Occupational Health ,Case-control study ,Ambientale ,Infant ,Carcinogens, Environmental ,Automobile ,Case-Control Studies ,Residence Characteristic ,Dispersion Model ,Etiology ,General Earth and Planetary Sciences ,Particulate Matter ,Residence ,business ,Automobiles - Abstract
Objectives Leukaemia is the most common cancer in children, but its aetiology is still poorly understood. We tested the hypothesis that traffic-related air pollution is associated with paediatric leukaemia because of chronic exposure to several potential carcinogens. Methods The Italian SETIL study (Study on the aetiology of lymphohematopoietic malignancies in children) was conducted in 14 Italian regions. All incident cases of leukaemia in children aged ≤10 years from these regions (period 1998–2001) were eligible for enrolment. Two controls per case, matched on birth date, gender and region of residence were randomly selected from the local population registries. Exposure assessment at birth residence included traffic indicators (distance to main roads and length of main roads within 100 m) and estimates of pollutants concentrations (particulate matter -PM 2.5 and PM 10 - and gases -NO 2 and O 3 -) from national dispersion model and land use regression models. The association between the exposure variables and leukaemia was assessed by logistic regression analyses. Results Participation rates were 91.4% among cases and 69.2% in controls; 620 cases (544 acute lymphocytic and 76 acute non-lymphocytic leukaemia) and 957 controls were included. Overall, when considering the residence at birth, 35.6% of cases and 42.4% of controls lived along busy roads, and the mean annual PM 10 levels were 33.3 (SD=6.3) and 33.4 µg/m 3 (SD=6.5), respectively. No association was found, and all ORs, independent of the method of assessment and the exposure windows, were close to the null value. Conclusions Using various exposure assessment strategies, air pollution appears not to affect the incidence of childhood leukaemia.
- Published
- 2013
29. Italian multicentricepidemiological case control strudy on risk factors for childhood leukemia,non hodgkin limphoma and neuroblastoma:study population and prevalence of risk factors in Italy
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Magnani, C, Mattioli, S, Miligi, L, Ranucci, A, Rondelli, R, Salvan, A, Bisanti, L, Masera, G, Rizzari, C, Zambon, P, Cannizzaro, S, Gafà, L, Luzzatto, LL, Benvenuti, A, Michelozzi, P, Kirchmayer, U, Cocco, P, Biddau, P, Galassi, C, Celentano, E, Guarino, E, Assennato, G, Nichilo, GD, Merlo, DF, Bocchini, V, Pannelli, F, Mosciatti, P, Minelli, L, Chiavarini, M, Cuttini, M, Casotto, V, Forastiere, F, Haupt, R, Lagorio, S, Risica, S, Polichetti, A., TORREGROSSA, Maria Valeria, VALENTI, Rosalia Maria, Magnani, C, Mattioli, S, Miligi, L, Ranucci, A, Rondelli, R, Salvan, A, Bisanti, L, Masera, G, Rizzari, C, Zambon, P, Cannizzaro, S, Gafà, L, Luzzatto, LL, Benvenuti, A, Michelozzi, P, Kirchmayer, U, Cocco, P, Biddau, P, Galassi, C, Celentano, E, Guarino, E, Assennato, G, Nichilo, GD, Merlo, DF, Bocchini, V, Pannelli, F, Mosciatti, P, Minelli, L, Chiavarini, M, Cuttini, M, Casotto, V, Torregrossa, MV, Valenti, RM, Forastiere, F, Haupt, R, Lagorio, S, Risica, S, and Polichetti, A
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Settore MED/42 - Igiene Generale E Applicata ,childhood leukemia, childhood neoplasm - Abstract
Background Aetiology of childhood leukaemia and childhood neoplasm is poorly understood. Information on the prevalence of risk factors in the childhood population is limited. SETIL is a population based case/control study on childhood leukaemia, conducted with two companion studies on non-Hodgkin Lymphoma (NHL) and neuroblastoma. The study relies on questionnaire interviews and 50 Hz magnetic field (ELF-MF) indoor measurements. This paper discusses the SETIL study design and includes descriptive information. Methods The study was carried out in 14 Italian regions (78.3% of Italian population aged 0?10). It included leukaemia, NHL and neuroblastoma cases incident in 0?10 year olds in 1998-2001,registered by the Italian Association of Paediatric Haematology and Oncology (AIEOP)(accrual over 95% of estimated incidence). Two controls for each leukaemia case were randomly sampled from the Local Health Authorities rolls, matched by gender, birthdate and residence. The same controls were used in NHL and neuroblastoma studies. Parents were interviewed at home on: physical agents (ELF-MF and ionizing radiation), chemicals (smoking, solvents, traffic, insecticides), occupation, medical and personal history of children and parents, infectious diseases, immunizations and associated factors. Occupational exposure was collected using job specific modules. ELF-MF was measured in the main rooms (spot measurement) and close to child?s bed (48 hours measurement). Results The study included: 683 leukaemia cases (87% ALL, 13% AnLL), 97 NHL, 155 neuroblastomas, and 1044 controls.ELF-MF long term measurements were obtained for 61.1% of controls and 81.6% of leukaemia cases; 8.8% of controls were exposed at over 0.1 microTesla (μT), 3.5% and 2.1% at respectively over 0.2 and 0.3 μT. 25% of controls? fathers had smoked over 10 cigarettes/day during the year of conception, varying according to education and region. Maternal smoking was less common (71.4% did not smoke in pregnancy). Maternal passive smoking during pregnancy was reported by 31.2% of controls; the child?s passive smoking for 28.6%. Occupational exposure to solvents was estimated in 18.3% of controls? fathers and 7.7% of mothers. Contact with public was more frequent among mothers (36.1%) than fathers (23.4%). Conclusions SETIL represents a data source on exposure of Italian children to a broad array of potential carcinogenic factors.
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- 2014
30. Risk of neuroblastoma, maternal characteristics and perinatal exposures: the SETIL study
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Parodi S, Merlo DF, Ranucci A, Miligi L, Benvenuti A, Rondelli R, Magnani C, Haupt R, Mattioli S, Salvan A, Masera G, Rizzari C, Bisanti L, Zambon P, Greco Veneto A, Cannizzaro S, Gafà L, Luzzatto LL, Michelozzi P, Kirchmayer U, Cocco P, Galassi C, Celentano E, Guarino E, Assennato G, de Nichilo G, Bocchini V, Mosciatti P, Pubblica S, Minelli L, Chiavarini M, Cuttini M, Casotto V, Torregrossa MV, Valenti RM, Forastiere F, Lagorio S, Risica S, Polichetti A, Bochicchio F, Nuccetelli C, Biddau P, Aricò M, DeSalvo GL, Locatelli F, Pession A, Varotto S, Poggi V, Massaglia P, Monetti D, Targhetta R, Bernini G, Lippi A, Nardi M, Acquaviva A, Pannelli F, Tumori R, Sampietro G, Schilirò G, Pulsoni A, Legittimo P, Barone Adesi F, Cavariani F, Belletti I, Troeschel L, Calisti R, Marche C, Silvestri S, Sommani L, Farioli A, Tozzi GA, Terracini B, Paolucci G, Andreuccetti D, Anglesio L, Bertolotti M, Bevitori P, Biancotto R, Biggeri A, Bucci S, Comba P, Crosignani P, d'Amore G, Duglio E, Erna M, Ferrante D, Gelli L, Gilardetti M, Guidotti P, Lombardi M, Loomis D, Magnoni M, Merletti F, Miceli G, Mozzo P, Poggi A, Pons O, Rasulo A, Roletti S, Rosa M, Mestre V, Ru O, Russo G, Sgorbati G, Simonato L, Sivo D, Stievano B, Tofani S, Troti F, Tumino R, Valle M, Vecchia P, Erminio G, Galleni B., PANICO, SALVATORE, Parodi, Stefano, Merlo, Domenico Franco, Ranucci, Alessandra, Miligi, Lucia, Benvenuti, Alessandra, Rondelli, Roberto, Magnani, Corrado, Haupt, Riccardo, [ .., Mattioli, Stefano, ], Parodi, S, Merlo, Df, Ranucci, A, Miligi, L, Benvenuti, A, Rondelli, R, Magnani, C, Haupt, R, Mattioli, S, Salvan, A, Masera, G, Rizzari, C, Bisanti, L, Zambon, P, Greco Veneto, A, Cannizzaro, S, Gafà, L, Luzzatto, Ll, Michelozzi, P, Kirchmayer, U, Cocco, P, Galassi, C, Celentano, E, Guarino, E, Assennato, G, de Nichilo, G, Bocchini, V, Mosciatti, P, Pubblica, S, Minelli, L, Chiavarini, M, Cuttini, M, Casotto, V, Torregrossa, Mv, Valenti, Rm, Forastiere, F, Lagorio, S, Risica, S, Polichetti, A, Bochicchio, F, Nuccetelli, C, Biddau, P, Aricò, M, Desalvo, Gl, Locatelli, F, Pession, A, Varotto, S, Poggi, V, Massaglia, P, Monetti, D, Targhetta, R, Bernini, G, Lippi, A, Nardi, M, Acquaviva, A, Pannelli, F, Tumori, R, Sampietro, G, Schilirò, G, Pulsoni, A, Legittimo, P, Barone Adesi, F, Cavariani, F, Belletti, I, Troeschel, L, Calisti, R, Marche, C, Silvestri, S, Sommani, L, Farioli, A, Tozzi, Ga, Terracini, B, Paolucci, G, Andreuccetti, D, Anglesio, L, Bertolotti, M, Bevitori, P, Biancotto, R, Biggeri, A, Bucci, S, Comba, P, Crosignani, P, D'Amore, G, Duglio, E, Erna, M, Ferrante, D, Gelli, L, Gilardetti, M, Guidotti, P, Lombardi, M, Loomis, D, Magnoni, M, Merletti, F, Miceli, G, Mozzo, P, Panico, Salvatore, Poggi, A, Pons, O, Rasulo, A, Roletti, S, Rosa, M, Mestre, V, Ru, O, Russo, G, Sgorbati, G, Simonato, L, Sivo, D, Stievano, B, Tofani, S, Troti, F, Tumino, R, Valle, M, Vecchia, P, Erminio, G, and Galleni, B.
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Cancer Research ,Pediatrics ,medicine.medical_specialty ,Epidemiology ,Socio-culturale ,ELF magnetic fields ,ELF magnetic field ,Nervous System Malformation ,Neuroblastoma ,Economica ,Work related exposure ,parental occupation ,male ,Pregnancy ,Risk Factors ,maternal exposure ,medicine ,Parental occupation ,Maternal characteristic ,Neurofibromatosis ,humans ,Neurofibromatosi ,neurofibromatosis ,business.industry ,Risk Factor ,Incidence (epidemiology) ,case-control studies ,Ambientale ,Congenital malformations ,nervous system malformations ,Odds ratio ,medicine.disease ,Pregnancy Complication ,Pregnancy Complications ,female ,Oncology ,congenital malformations ,maternal characteristics ,neuroblastoma ,incidence ,Etiology ,Congenital malformation ,Case-Control Studie ,business ,Human - Abstract
Purpose: Neuroblastoma (NB) is the most common extra-cranial paediatric solid tumour. Incidence peaks in infancy, suggesting a role of in-utero and neonatal exposures but its aetiology is largely unknown. The aim of the present study is to evaluate the association between maternal characteristics and perinatal factors with the risk of NB, using data from the SETIL database. Methods: SETIL is a large Italian population-based case-control study established to evaluate several potential cancer risk factors in 0-10 year olds. Information about maternal characteristics, reproductive history, environmental and occupational exposures during pregnancy, as well as newborns' characteristics were obtained using a structured questionnaire. Extremely low frequency magnetic field (ELF-MF) home exposure was measured. The study included 1044 healthy controls and 153 NB cases, diagnosed between 1998 and 2001. Results: A twofold risk was associated to exposure in pregnancy to chemical products for domestic work and to hair dye. The risk associated with the latter was higher among 0-17 month old children (OR. =. 5.5, 95%CI: 1.0-29.3). Risk was increased for children whose mothers had suffered work related exposure in the preconception period to solvents (OR. =. 2.0 95%CI: 1.0-4.1) and in particular to aromatic hydrocarbons (OR. =. 9.2, 95%CI: 2.4-34.3). No association was observed with ELF-MF exposure. A higher risk was found among children with congenital malformations (OR. =. 4.9, 95%CI: 1.8-13.6) or neurofibromatosis (2 cases and 0 controls, p=. 0.016). Conclusions: Our study suggests maternal exposure to hair dyes and aromatic hydrocarbons plays a role and deserves further investigation. The association with congenital malformations might also be explained by over-diagnosis.External exposure, in particular during and before pregnancy might contribute to NB occurrence.
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- 2014
31. [SENTIERI-ReNaM: Discussion and concluding remarks]
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Zona, Amerigo, Fazzo, Lucia, Binazzi, Alessandra, Bruno, Caterina, Corfiati, Marisa, Comba, Pietro, Conti, Susanna, Menegozzo, Simona, Nicita, Carmela, Pasetto, Roberto, Pirastu, Roberta, Marinaccio, Alessandro, Binazzi A, GdL SENTIERI-ReNaM., Bruno, C, Comba, P, Conti, S, Corfiati, M, Fazzo, L, Manno, V, Marinaccio, A, Menegozzo, S, Minelli, G, Pasetto, R, Pirastu, R, Zona, A, Angelillo, I, Canessa, Pa, Cauzillo, G, Cavone, D, Chellini, E, Cocchioni, M, De Michieli, P, Forastiere, F, Davoli, M, Di Giammarco, A, Gennaro, V, Giaimo, M, Gioffrè, F, Mangone, L, Mazzoleni, G, Mensi, C, Merler, E, Merletti, F, Merseburger, A, Miligi, L, Mirabelli, D, Musti, M, Negro, C, Nicita, C, Pascucci, C, Riboldi, L, Romanelli, A, Schallemberg, G, Stracci, F, Trafficante, L, and Tumino, R.
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Male ,Mesothelioma ,Risk ,Incidence ,Asbestos ,Environmental Exposure ,Health Surveys ,Carcinogens, Environmental ,Environmental ,Italy ,Occupational Exposure ,Hazardous Waste Sites ,Carcinogens ,Confidence Intervals ,Humans ,Industry ,Female ,Registries ,Environmental Pollution - Abstract
SENTIERI-ReNaM Project analysed the incidence of malignant mesothelioma (MM) for the period 2000-2011 in 39 National Priority Contaminated Sites (NPCSs), and assessed the overall impact of mesothelioma in different types of NPCSs. In the study period, 2,683 incident cases of malignant mesothelioma were recorded: 1,998 males (74.5%), 685 females (25.5%). Excluding cases with non attributable exposure and those non interviewed, exposure was identified in 1,926 cases (70% of all cases): 1,541 males (occupational exposure: 1,414; environmental exposure: 82), 385 females (occupational exposure: 103; environmental exposure: 141). Women experienced mainly environmental and domestic exposures to asbestos. Standard Incidence Ratio (SIR) excesses were observed in men in 27 out of 39 NPCSs and defects in the remaining 12; in women, 20 NPCSs showed SIR excesses, defects in 15; in 4 NPCSs no MM cases occurred among female population. The highest rates were found in NPCSs with asbestos-cement plants (Broni and Casale Monferrato), respectively, 98 per 100,000 per year and 68.6 in men, 72.1 and 45.8 in women. Excluding these two sites, the highest incidence rates were found in the group with harbours and shipyards, where the rates were, respectively, 13.2 among men and 2.5 among women. The results of this report will be communicated to national and local institutions, as well as to NPCSs resident populations.
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- 2016
32. [SENTIERI-ReNaM: Results]
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Binazzi, Alessandra, Zona, Amerigo, Marinaccio, Alessandro, Bruno, Caterina, Corfiati, Marisa, Fazzo, Lucia, Menegozzo, Simona, Nicita, Carmela, Pasetto, Roberto, Pirastu, Roberta, De Santisi, Marco, Comba, Pietro, Binazzi A, GdL SENTIERI-ReNaM., Bruno, C, Comba, PAOLO GIOVANNI, Conti, S, Corfiati, M, Fazzo, L, Manno, V, Marinaccio, A, Menegozzo, S, Minelli, G, Pasetto, R, Pirastu, R, Zona, A, Angelillo, I, Canessa, Pa, Cauzillo, G, Cavone, D, Chellini, E, Cocchioni, M, De Michieli, P, Forastiere, F, Davoli, M, Di Giammarco, A, Gennaro, V, Giaimo, M, Gioffrè, F, Mangone, L, Mazzoleni, G, Mensi, C, Merler, E, Merletti, F, Merseburger, A, Miligi, L, Mirabelli, D, Musti, M16, 17 Negro, C, Nicita, C, Pascucci, C, Riboldi, L, Romanelli, A, Schallemberg, G, Stracci, F, Trafficante, L, and Tumino, R.
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Male ,Mesothelioma ,Risk ,Incidence ,Asbestos ,Environmental Exposure ,Health Surveys ,Carcinogens, Environmental ,Environmental ,Italy ,Occupational Exposure ,Hazardous Waste Sites ,Carcinogens ,Confidence Intervals ,Humans ,Industry ,Female ,Registries ,Environmental Pollution - Abstract
Mesothelioma incidence has been analyzed in National Priority Contaminated Sites (NPCSs) to estimate the health impact of asbestos exposure on resident people. The burden of professional and environmental exposures has been identified through data of the Regional Operational Centres (CORs), made available by the Italian National Mesothelioma Registry (ReNaM). An excess of mesothelioma incidence is confirmed in sites with a known past history of direct use of asbestos, such as Balangero, Casale Monferrato, Broni, Bari-Fibronit, and in coastal areas, where shipyards, harbours and other industries that involved a wide use of asbestos are represented (e.g., Trieste, La Spezia, Venice, and Leghorn). An excess of mesothelioma has been observed in settings where the asbestos is not mentioned as contaminant in the decree that included these sites among NPCSs, such as Cengio and Saliceto in Northern Italy; Falconara Marittima and the Bacino Idrografico Fiume Sacco in the Central Italy; the Litorale Domizio Flegreo and Agro Aversano, Milazzo, and Gela in the Southern Italy. Observed excess in the various NPCSs confirms the large-scale occurrence in contaminated Italian sites of a significant amount of total mesothelioma cases observed at national level. The analysis of occupational risk in epidemiological studies with an ecological design helps in defining the contribution of different factors to the overall risk.
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- 2016
33. Home pesticide exposures and risk of childhood leukemia: Findings from the childhood leukemia international consortium
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Bailey, H.D. Infante-Rivard, C. Metayer, C. Clavel, J. Lightfoot, T. Kaatsch, P. Roman, E. Magnani, C. Spector, L.G. Th. Petridou, E. Milne, E. Dockerty, J.D. Miligi, L. Armstrong, B.K. Rudant, J. Fritschi, L. Simpson, J. Zhang, L. Rondelli, R. Baka, M. Orsi, L. Moschovi, M. Kang, A.Y. Schüz, J.
- Abstract
Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case-control studies in the Childhood Leukemia International Consortium. Exposure data were harmonized into compatible formats. Pooled analyses were undertaken using multivariable unconditional logistic regression. The odds ratio (ORs) for acute lymphoblastic leukemia (ALL) associated with any pesticide exposure shortly before conception, during pregnancy and after birth were 1.39 (95% confidence interval [CI]: 1.25, 1.55) (using 2,785 cases and 3,635 controls), 1.43 (95% CI: 1.32, 1.54) (5,055 cases and 7,370 controls) and 1.36 (95% CI: 1.23, 1.51) (4,162 cases and 5,179 controls), respectively. Corresponding ORs for risk of acute myeloid leukemia (AML) were 1.49 (95% CI: 1.02, 2.16) (173 cases and 1,789 controls), 1.55 (95% CI: 1.21, 1.99) (344 cases and 4,666 controls) and 1.08 (95% CI: 0.76, 1.53) (198 cases and 2,655 controls), respectively. There was little difference by type of pesticide used. The relative similarity in ORs between leukemia types, time periods and pesticide types may be explained by similar exposure patterns and effects across the time periods in ALL and AML, participants' exposure to multiple pesticides, or recall bias. Although some recall bias is likely, until a better study design can be found to investigate the associations between home pesticide use and childhood leukemia in an equally large sample, it would appear prudent to limit the use of home pesticides before and during pregnancy, and during childhood. What's new? Some studies have suggested that early pesticide exposure may increase the risk of childhood leukemia. In this investigation, the authors pooled individual level data from twelve previous case-control studies to further examine this question. They found an association between home pesticide exposure before birth and during a child's early years and acute lymphoblastic leukemia (ALL) and with exposure before birth and acute myeloid leukemia (AML). These results indicate that it would be prudent for parents to limit the use of home pesticides before and after a child's birth. © 2015 UICC.
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- 2015
34. TOBACCO SMOKE AND RISK OF CHILDHOOD LEUKAEMIA: FINDINGS FROM THE SETIL CASE-CONTROL STUDY
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Farioli, A., Legittimo, P., Stefano Mattioli, Miligi, L., Benvenuti, A., Ranucci, A., Salvan, A., Magnani, C., Farioli, A, Legittimo, P, Mattioli, S, Miligi, L, Benvenuti, A, Ranucci, A, Salvan, A, and Magnani, C
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Economica ,Socio-culturale ,Leukaemia ,smoking - Abstract
Introduction. Tobacco smoke could cause childhood leukaemia through at least two different pathways: 1) prenatal parental smoking; 2) childhood exposure to environmental tobacco smoke (ETS). Objectives. To explore these two possible risk factors for acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML), we analyzed data collected in a large case control study (SETIL) primarily designed to evaluate the role of electromagnetic fields in childhood haematopoietic malignancies. Methods.We focused on incident cases (with informed consent) of ALL (n=602) and AML (n=83) in 14 Italian Regions during 1998- 2001, individually matched (2:1) by age, sex and Region with controls randomly drawn from the general population (matching was broken in the present analysis). We conducted separate logistic regressions for ALL and AML, conditioned to Region and adjusted for child age and sex. Results. Analysis of AML data showed a 3-way interaction (p=0.003) between paternal preconception smoking, maternal smoking during pregnancy, and maternal age. Remarkably, heavy smokers (>10 cigarettes/day) appeared to be at raised risk of having a child affected by childhood AML when maternal age was =1 cigarette/day) to ETS (OR 1.5; 95%CI 1.1-2.0; reference, never exposed); intriguingly, risk appeared more pronounced (OR 2.5; 95%CI 1.4-4.4) in “late-onset” cases (age >=6 years). No association was detected with prenatal exposure. Conclusion.We hypothesize that young maternal age could modulate risks of childhood AML determined by parental smoking (plausibly due to age-related metabolic differences). This study also supports the concept that childhood exposure to ETS could be a risk factor for ALL.
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- 2010
35. Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: Findings from the childhood leukemia international consortium
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Bailey, H.D. Fritschi, L. Infante-Rivard, C. Glass, D.C. Miligi, L. Dockerty, J.D. Lightfoot, T. Clavel, J. Roman, E. Spector, L.G. Kaatsch, P. Metayer, C. Magnani, C. Milne, E. Polychronopoulou, S. Simpson, J. Rudant, J. Sidi, V. Rondelli, R. Orsi, L. Kang, A.Y. Petridou, E. Schüz, J.
- Abstract
Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Pooled individual analyses were undertaken using unconditional logistic regression. Using exposure data from mothers of 8,236 cases, and 14,850 controls, and from fathers of 8,169 cases and 14,201 controls the odds ratio (OR) for maternal exposure during pregnancy and the risk of acute lymphoblastic leukemia (ALL) was 1.01 [95% confidence interval (CI) 0.78, 1.30] and for paternal exposure around conception 1.20 (95% 1.06, 1.38). For acute myeloid leukemia (AML), the OR for maternal exposure during pregnancy was 1.94 (CI 1.19, 3.18) and for paternal exposure around conception 0.91 (CI 0.66, 1.24.) based on data from 1,329 case and 12,141 control mothers, and 1,231 case and 11,383 control fathers. Our finding of a significantly increased risk of AML in the offspring with maternal exposure to pesticides during pregnancy is consistent with previous reports. We also found a slight increase in risk of ALL with paternal exposure around conception which appeared to be more evident in children diagnosed at the age of 5 years or more and those with T cell ALL which raises interesting questions on possible mechanisms. What's new? When parents are exposed to pesticides during pregnancy or conception, does this increase the risk of leukemia in their child? The answer is yes. Using pooled individual level occupational pesticide exposure data from 13 case-control studies the authors found an increased risk of acute myeloid leukemia with maternal exposure during pregnancy and a slightly increased risk of acute lymphoblastic leukemia with paternal exposure around conception. The next step is to get more detailed information on pesticide types and protective measures during application before conclusive recommendations for pesticide use in the workforce can be made. © 2014 UICC.
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- 2014
36. The MOBI-Kids study protocol: Challenges in assessing childhood and adolescent exposure to electromagnetic fields from wireless telecommunication technologies and possible association with brain tumor risk
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Sadetzki, S. Langer, C.E. Bruchim, R. Kundi, M. Merletti, F. Vermeulen, R. Kromhout, H. Ae-Kyoung, L. Maslanyj, M. Sim, M.R. Taki, M. Wiart, J. Armstrong, B. Milne, E. Benke, G. Schattner, R. Hutter, H.-P. Woehrer, A. Krewski, D. Mohipp, C. Momoli, F. Ritvo, P. Spinelli, J. Lacour, B. Delmas, D. Remen, T. Radon, K. Weinmann, T. Klostermann, S. Heinrich, S. Petridou, E. Bouka, E. Panagopoulou, P. Dikshit, R. Nagrani, R. Even-Nir, H. Chetrit, A. Maule, M. Migliore, E. Filippini, G. Miligi, L. Mattioli, S. Yamaguchi, N. Kojimahara, N. Ha, M. Choi, K.-H. Mannetje, A. Eng, A. Woodward, A. Carretero, G. Alguacil, J. Aragones, N. Suare-Varela, M.M. Goedhart, G. Schouten-van Meeteren, A.A.Y.N. Reedijk, A.A.M.J. Cardis, E.
- Abstract
The rapid increase in mobile phone use in young people has generated concern about pos- sible health effects of exposure to radiofrequency (RF) and extremely low frequency (ELF) electromagnetic fields (EMF). MOBI-Kids, a multinational case-control study, investigates the potential effects of childhood and adolescent exposure to EMF from mobile communi- cations technologies on brain tumor risk in 14 countries. The study, which aims to include approximately 1,000 brain tumor cases aged 10-24 years and two individually matched controls for each case, follows a common protocol and builds upon the methodological experience of the INTERPHONE study. The design and conduct of a study on EMF expo- sure and brain tumor risk in young people in a large number of countries is complex and poses methodological challenges.This manuscript discusses the design of MOBI-Kids and describes the challenges and approaches chosen to address them, including: (1) the choice of controls operated for suspected appendicitis, to reduce potential selection bias related to lowresponse rates among population controls; (2) investigating a young study population spanning a relatively wide age range; (3) conducting a large, multinational epidemiologi- cal study, while adhering to increasingly stricter ethics requirements; (4) investigating a rare and potentially fatal disease; and (5) assessing exposure to EMF from communication technologies. Our experience in thus far developing and implementing the study protocol indicates that MOBI-Kids is feasible and will generate results that will contribute to the understanding of potential brain tumor risks associated with use of mobile phones and other wireless communications technologies among young people. © 2014.
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- 2014
37. Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium
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Bailey, H.D. Fritschi, L. Metayer, C. Infante-Rivard, C. Magnani, C. Petridou, E. Roman, E. Spector, L.G. Kaatsch, P. Clavel, J. Milne, E. Dockerty, J.D. Glass, D.C. Lightfoot, T. Miligi, L. Rudant, J. Baka, M. Rondelli, R. Amigou, A. Simpson, J. Kang, A.Y. Moschovi, M. Schüz, J.
- Abstract
Purpose: It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring. Methods: We obtained individual level data from 13 case–control studies participating in the Childhood Leukemia International Consortium. Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression. Results: Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93 [95 % confidence interval (CI) 0.76, 1.14]. Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95 % CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95 % CI 0.65, 1.41) and 1.31 (95 % CI 0.38, 4.47), respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest. Conclusions: Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed. © 2014, Springer International Publishing Switzerland.
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- 2014
38. MOBI-KIDS STUDY: EXPOSURE TO COMMUNICATION TECHNOLOGIES AND BRAIN TUMOUR RISK IN CHILDREN AND ADOLESCENTS
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Maule, MILENA MARIA, Cardis, E., Eastman Langer, C., Sadetzki, S., Filippini, G., Farinotti, M., Miligi, L., Mattioli, S., Merletti, Franco, and MOBI KIDS Study Group
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- 2014
39. Setil:Italian multicentric epidemiological study on risk factors for childhood leukemia, non Hodgkin lymphoma and neuroblastoma
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Magnani,C, TORREGROSSA, Maria Valeria, V, Assennato,G, Bisanti,L, Cannizzaro,S, Celentano,E, Cocco,L, Cuttini,M, DeSalvo,G, Forastiere,F, Haupt,R, Lagorio,S, Mattioli,S, Merlo,F, Michelozzi,P, Miligi,L, Magnani,C, Torregrossa,M,V, Assennato,G, Bisanti,L, Cannizzaro,S, Celentano,E, Cocco,L, Cuttini,M, DeSalvo,G, Forastiere,F, Haupt,R, Lagorio,S, Mattioli,S, Merlo,F, Michelozzi,P, and Miligi,L
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epidemiology, risk factors, leukemia ,Settore MED/42 - Igiene Generale E Applicata - Published
- 2008
40. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
- Author
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Berndt, S.I., Skibola, C.F., Joseph, V., Camp, N.J., Nieters, A., Wang, Z., Cozen, W., Monnereau, A., Wang, S.S., Kelly, R.S., Lan, Q., Teras, L.R., Chatterjee, N., Chung, C.C., Yeager, M., Brooks-Wilson, A.R., Hartge, P., Purdue, M.P., Birmann, B.M., Armstrong, B.K., Cocco, P., Zhang, Y., Severi, G., Zeleniuch-Jacquotte, A., Lawrence, C., Burdette, L., Yuenger, J., Hutchinson, A., Jacobs, K.B., Call, T.G., Shanafelt, T.D., Novak, A.J., Kay, N.E., Liebow, M., Wang, A.H., Smedby, K.E., Adami, H.-O., Melbye, M., Glimelius, B., Chang, E.T., Glenn, M., Curtin, K., Cannon-Albright, L.A., Jones, B., Diver, W.R., Link, B.K., Weiner, G.J., Conde, L., Bracci, P.M., Riby, J., Holly, E.A., Smith, M.T., Jackson, R.D., Tinker, L.F., Benavente, Y., Becker, N., Boffetta, P., Brennan, P., Foretova, L., Maynadie, M., McKay, J., Staines, A., Rabe, K.G., Achenbach, S.J., Vachon, C.M., Goldin, L.R., Strom, S.S., Lanasa, M.C., Spector, L.G., Leis, J.F., Cunningham, J.M., Weinberg, J.B., Morrison, V.A., Caporaso, N.E., Norman, A.D., Linet, M.S., De Roos, A.J., Morton, L.M., Severson, R.K., Riboli, E., Vineis, P., Kaaks, R., Trichopoulos, D., Masala, G., Weiderpass, E., Chirlaque, M.-D., Vermeulen, R.C.H., Travis, R.C., Giles, G.G., Albanes, D., Virtamo, J., Weinstein, S., Clavel, J., Zheng, T., Holford, T.R., Offit, K., Zelenetz, A., Klein, R.J., Spinelli, J.J., Bertrand, K.A., Laden, F., Giovannucci, E., Kraft, P., Kricker, A., Turner, J., Vajdic, C.M., Ennas, M.G., Ferri, G.M., Miligi, L., Liang, L., Sampson, J., Crouch, S., Park, J.-H., North, K.E., Cox, A., Snowden, J.A., Wright, J., Carracedo, A., Lopez-Otin, C., Bea, S., Salaverria, I., Martin-Garcia, D., Campo, E., Jr, F.J.F., de Sanjose, S., Hjalgrim, H., Cerhan, J.R., Chanock, S.J., Rothman, N., and Slager, S.L.
- Abstract
Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 × 10−14), 18q21.33 (BCL2, P = 7.76 × 10−11), 11p15.5 (C11orf21, P = 2.15 × 10−10), 4q25 (LEF1, P = 4.24 × 10−10), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 × 10−9), 9p21.3 (CDKN2B-AS1, P = 1.27 × 10−8), 18q21.32 (PMAIP1, P = 2.51 × 10−8), 15q15.1 (BMF, P = 2.71 × 10−10) and 2p22.2 (QPCT, P = 1.68 × 10−8), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 × 10−18). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 × 10−8) and 5p15.33 (TERT, P = 1.92 × 10−7). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.
- Published
- 2013
41. Rischio da radiazione solare ultravioletta nei lavoratori outdoor: piano mirato della Regione Toscana
- Author
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Miligi, L., Benvenuti, A., Legittimo, P., Badiali, Am, Cacciarini, V., Chiarugi, A., Crocetti, E., Alberghini Maltoni, S., Pinto, I., Zipoli, G., Grifoni, D., Carnevale, F., Pimpinelli, N., Cherubini Di Simplicio, F., Poggiali, S., PIETRO SARTORELLI, Sirna, R., Amati, R., Centi, L., Festa, G., Fiumalbi, C., Fedi, A., Giglioli, S., Mancini, R., Panzone, T., Petrioli, G., Trombetti, A., and Volpi, D.
- Published
- 2013
42. The Childhood Leukemia International Consortium
- Author
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Metayer, C. Milne, E. Clavel, J. Infante-Rivard, C. Petridou, E. Taylor, M. Schüz, J. Spector, L.G. Dockerty, J.D. Magnani, C. Pombo-de-Oliveira, M.S. Sinnett, D. Murphy, M. Roman, E. Monge, P. Ezzat, S. Mueller, B.A. Scheurer, M.E. Armstrong, B.K. Birch, J. Kaatsch, P. Koifman, S. Lightfoot, T. Bhatti, P. Bondy, M.L. Rudant, J. O'Neill, K. Miligi, L. Dessypris, N. Kang, A.Y. Buffler, P.A.
- Abstract
Background: Acute leukemia is the most common cancer in children under 15 years of age; 80% are acute lymphoblastic leukemia (ALL) and 17% are acute myeloid leukemia (AML). Childhood leukemia shows further diversity based on cytogenetic and molecular characteristics, which may relate to distinct etiologies. Case-control studies conducted worldwide, particularly of ALL, have collected a wealth of data on potential risk factors and in some studies, biospecimens. There is growing evidence for the role of infectious/immunologic factors, fetal growth, and several environmental factors in the etiology of childhood ALL. The risk of childhood leukemia, like other complex diseases, is likely to be influenced both by independent and interactive effects of genes and environmental exposures. While some studies have analyzed the role of genetic variants, few have been sufficiently powered to investigate gene-environment interactions. Objectives: The Childhood Leukemia International Consortium (CLIC) was established in 2007 to promote investigations of rarer exposures, gene-environment interactions and subtype-specific associations through the pooling of data from independent studies. Methods: By September 2012, CLIC included 22 studies (recruitment period: 1962-present) from 12 countries, totaling approximately 31. 000 cases and 50. 000 controls. Of these, 19 case-control studies have collected detailed epidemiologic data, and DNA samples have been collected from children and child-parent trios in 15 and 13 of these studies, respectively. Two registry-based studies and one study comprising hospital records routinely obtained at birth and/or diagnosis have limited interview data or biospecimens. Conclusions: CLIC provides a unique opportunity to fill gaps in knowledge about the role of environmental and genetic risk factors, critical windows of exposure, the effects of gene-environment interactions and associations among specific leukemia subtypes in different ethnic groups. © 2013 Elsevier Ltd.
- Published
- 2013
43. Analisi microgeografica dell’incidenza di tumori del sistema linfoematopoietico in una area della regione toscana
- Author
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Minichilli, F, Mugnaini, E, Vigotti, MARIA ANGELA, Miligi, L, Scala, D, Bianchi, F, Cori, L, Battisti, F, and Petronio, M. G.
- Published
- 2013
44. Cluster di leucemie nel Comune di Montopoli in Valdarno
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Petronio, Mg, Mugnaini, E, Franchini, M, Vigotti, MARIA ANGELA, Miligi, L, Bianchi, F, Protti, Ma, Minniti, C, Scala, D, Cavazza, E, Balli, M, and Guarducci, S.
- Published
- 2011
45. Parental Tobacco Smoking and the Risk of Acute Myeloid Leukemia in Children: the Childhood Leukemia International Consortium (CLIC).
- Author
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Metayer, C., primary, Roman, E., additional, Petridou, E., additional, Mejía Aranguré, J. M., additional, Schüz, J., additional, Magnani, C., additional, Mora, A. M., additional, Mueller, B., additional, Koifman, S., additional, Dockerty, J., additional, Lightfoot, T., additional, Hatzipanatelis, E., additional, Rudant, J., additional, Flores-Lujano, J., additional, Kaatsch, P., additional, Miligi, L., additional, Wesseling, C., additional, Doody, D. R., additional, Pombo-de-Oliveira, M. S., additional, Kang, A. Y., additional, McCauley, K., additional, and Clavel, J., additional
- Published
- 2015
- Full Text
- View/download PDF
46. SETIL Study (Italian epidemiological study on the aetiology of childhood leukemia, lymphoma and neuroblastoma): risk of childhood cancers in relation to parental occupational exposure
- Author
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Miligi, L., Magnani, C., Benvenuti, A., Legittimo, P., Mattioli, S., Salvan, A., Ranucci, A., and SETIL Working Group
- Published
- 2010
47. Un sistema di monitoraggio per i tumori di origine professionale
- Author
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Crosignani, P., Nesti, M., Audisio, R., Amendola, P., Cavuto, S., Scaburri, A., Zambon, P., Nedoclan, Giovanni, Stracci, F., Pannelli, F., Miligi, L., Vercelli, M., P., Crosignani, M., Nesti, R., Audisio, P., Amendola, S., Cavuto, A., Scaburri, P., Zambon, Nedoclan, Giovanni, F., Stracci, F., Pannelli, L., Miligi, and M., Vercelli
- Published
- 2005
48. Il progetto italiano per il monitoraggio dei tumori professionali (OCCAM): nuovi risultati
- Author
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Crosignani, P, Nesti, M, Audisio, R, Amendola, P, Scaburri, A, Vercelli, Marina, Zambon, P, Pannelli, F, LA ROSA, F, Nedocian, G, and Miligi, L.
- Subjects
monitoring ,occupational cancers - Published
- 2004
49. Medical History, Lifestyle, Family History, and Occupational Risk Factors for Follicular Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
- Author
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Linet, M. S., primary, Vajdic, C. M., additional, Morton, L. M., additional, de Roos, A. J., additional, Skibola, C. F., additional, Boffetta, P., additional, Cerhan, J. R., additional, Flowers, C. R., additional, de Sanjose, S., additional, Monnereau, A., additional, Cocco, P., additional, Kelly, J. L., additional, Smith, A. G., additional, Weisenburger, D. D., additional, Clarke, C. A., additional, Blair, A., additional, Bernstein, L., additional, Zheng, T., additional, Miligi, L., additional, Clavel, J., additional, Benavente, Y., additional, and Chiu, B. C. H., additional
- Published
- 2014
- Full Text
- View/download PDF
50. Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project
- Author
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Morton, L. M., primary, Sampson, J. N., additional, Cerhan, J. R., additional, Turner, J. J., additional, Vajdic, C. M., additional, Wang, S. S., additional, Smedby, K. E., additional, de Sanjose, S., additional, Monnereau, A., additional, Benavente, Y., additional, Bracci, P. M., additional, Chiu, B. C. H., additional, Skibola, C. F., additional, Zhang, Y., additional, Mbulaiteye, S. M., additional, Spriggs, M., additional, Robinson, D., additional, Norman, A. D., additional, Kane, E. V., additional, Spinelli, J. J., additional, Kelly, J. L., additional, Vecchia, C. L., additional, Dal Maso, L., additional, Maynadie, M., additional, Kadin, M. E., additional, Cocco, P., additional, Costantini, A. S., additional, Clarke, C. A., additional, Roman, E., additional, Miligi, L., additional, Colt, J. S., additional, Berndt, S. I., additional, Mannetje, A., additional, de Roos, A. J., additional, Kricker, A., additional, Nieters, A., additional, Franceschi, S., additional, Melbye, M., additional, Boffetta, P., additional, Clavel, J., additional, Linet, M. S., additional, Weisenburger, D. D., additional, and Slager, S. L., additional
- Published
- 2014
- Full Text
- View/download PDF
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