34 results on '"Mileva-Seitz, Viara R."'
Search Results
2. How Being Mothered Affects the Development of Mothering
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Mileva-Seitz, Viara R., Fleming, Alison S., Deater-Deckard, Kirby, editor, and Panneton, Robin, editor
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- 2017
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3. The dopamine D4 receptor gene, birth weight, maternal depression, maternal attention, and the prediction of disorganized attachment at 36 months of age: A prospective gene × environment analysis
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Graffi, Justin, Moss, Ellen, Jolicoeur-Martineau, Alexia, Moss, Gal, Lecompte, Vanessa, Pascuzzo, Katherine, Babineau, Vanessa, Gordon-Green, Cathryn, Mileva-Seitz, Viara R., Minde, Klaus, Sassi, Roberto, Steiner, Meir, Kennedy, James L., Gaudreau, Helene, Levitan, Robert, Meaney, Michael J., and Wazana, Ashley
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- 2018
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4. Parent-child bed-sharing: The good, the bad, and the burden of evidence
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Mileva-Seitz, Viara R., Bakermans-Kranenburg, Marian J., Battaini, Chiara, and Luijk, Maartje P.C.M.
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- 2017
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5. Genetic mechanisms of parenting
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Mileva-Seitz, Viara R., Bakermans-Kranenburg, Marian J., and van IJzendoorn, Marinus H.
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- 2016
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6. The magnificent seven: A quantitative review of dopamine receptor d4 and its association with child behavior
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Pappa, Irene, Mileva-Seitz, Viara R., Bakermans-Kranenburg, Marian J., Tiemeier, Henning, and van IJzendoorn, Marinus H.
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- 2015
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7. Single Nucleotide Polymorphism Heritability of Behavior Problems in Childhood: Genome-Wide Complex Trait Analysis
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Pappa, Irene, Fedko, Iryna O., Mileva-Seitz, Viara R., Hottenga, Jouke-Jan, Bakermans-Kranenburg, Marian J., Bartels, Meike, van Beijsterveldt, Catharina E.M., Jaddoe, Vincent W.V., Middeldorp, Christel M., Rippe, Ralph C.A., Rivadeneira, Fernando, Tiemeier, Henning, Verhulst, Frank C., van IJzendoorn, Marinus H., and Boomsma, Dorret I.
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- 2015
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8. Are boys more sensitive to sensitivity? Parenting and executive function in preschoolers
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Mileva-Seitz, Viara R., Ghassabian, Akhgar, Bakermans-Kranenburg, Marian J., van den Brink, Jessica D., Linting, Marielle, Jaddoe, Vincent W.V., Hofman, Albert, Verhulst, Frank C., Tiemeier, Henning, and van IJzendoorn, Marinus H.
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- 2015
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9. DRD4 VNTRs, observed stranger fear in preschoolers and later ADHD symptoms
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Pappa, Irene, Mileva-Seitz, Viara R., Szekely, Eszter, Verhulst, Frank C., Bakermans-Kranenburg, Marian J., Jaddoe, Vincent W.V., Hofman, Albert, Tiemeier, Henning, and van IJzendoorn, Marinus H.
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- 2014
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10. Ethnic differences in prevalence and determinants of mother–child bed-sharing in early childhood
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Luijk, Maartje P.C.M., Mileva-Seitz, Viara R., Jansen, Pauline W., van IJzendoorn, Marinus H., Jaddoe, Vincent W.V., Raat, Hein, Hofman, Albert, Verhulst, Frank C., and Tiemeier, Henning
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- 2013
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11. Preschool family irregularity and the development of sleep problems in childhood: a longitudinal study
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Koopman‐Verhoeff, Maria Elisabeth, primary, Serdarevic, Fadila, additional, Kocevska, Desana, additional, Bodrij, F. Fenne, additional, Mileva‐Seitz, Viara R., additional, Reiss, Irwin, additional, Hillegers, Manon H.J., additional, Tiemeier, Henning, additional, Cecil, Charlotte A.M., additional, Verhulst, Frank C., additional, and Luijk, Maartje P.C.M., additional
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- 2019
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12. The bidirectional association between sleep problems and autism spectrum disorder: a population-based cohort study
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Verhoeff, Maria E., primary, Blanken, Laura M. E., additional, Kocevska, Desana, additional, Mileva-Seitz, Viara R., additional, Jaddoe, Vincent W. V., additional, White, Tonya, additional, Verhulst, Frank, additional, Luijk, Maartje P. C. M., additional, and Tiemeier, Henning, additional
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- 2018
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13. Heritability and genome-wide association analyses of sleep duration in children: The EAGLE Consortium
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Marinelli, Marcella, Pappa, Irene, Bustamante, Mariona, Bonilla, Carolina, Suarez, Anna, Tiesler, Carla M, Vilor-Tejedor, Natalia, Zafarmand, Mohammad Hadi, Alvarez-Pedrerol, Mar, Andersson, Sture, Bakermans-Kranenburg, Marian J, Estivill, Xavier, Evans, David M, Flexeder, Claudia, Fons, Joan, Gonzalez, Juan R, Guxens, Monica, Huss, Anke, van IJzendoorn, Marinus H, Jaddoe, Vincent W V, Julvez, Jordi, Lahti, Jari, López-Vicente, Mónica, Lopez-Espinosa, Maria-Jose, Manz, Judith, Mileva-Seitz, Viara R, Perola, Markus, Pesonen, Anu-Katriina, Rivadeneira, Fernando, Salo, Perttu P, Shahand, Shayan, Schulz, Holger, Standl, Marie, Thiering, Elisabeth, Timpson, Nicholas J, Torrent, Maties, Uitterlinden, André G, Smith, George Davey, Estarlich, Marisa, Heinrich, Joachim, Räikkönen, Katri, Vrijkotte, Tanja G M, Tiemeier, Henning, Sunyer, Jordi, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), dIRAS RA-2, Child and Adolescent Psychiatry / Psychology, Research Methods and Techniques, Epidemiology, Erasmus MC other, Pediatrics, Internal Medicine, Public Health, Psychiatry, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), dIRAS RA-2, Amsterdam Cardiovascular Sciences, Amsterdam Public Health, Other Research, Public and occupational health, Epidemiology and Data Science, and Amsterdam Reproduction & Development (AR&D)
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Male ,0301 basic medicine ,Time Factors ,Adolescent ,Sleep Duration/Sleep Quality ,Population ,Single-nucleotide polymorphism ,Genome-wide association study ,Polymorphism, Single Nucleotide ,White People ,SNP heritability ,Cohort Studies ,03 medical and health sciences ,Quantitative Trait, Heritable ,0302 clinical medicine ,030225 pediatrics ,Physiology (medical) ,Genetic variation ,Humans ,SNP ,Medicine ,Longitudinal Studies ,Child ,education ,education.field_of_study ,business.industry ,Excessive sleep ,Heritability ,genome-wide association study (GWAS) ,medicine.disease ,3. Good health ,pathway analysis ,meta-analysis ,030104 developmental biology ,Diabetes Mellitus, Type 2 ,Child, Preschool ,Meta-analysis ,Female ,Neurology (clinical) ,Sleep ,business ,childhood sleep duration ,Snp Heritability ,Genome-wide Association Study (gwas) ,Childhood Sleep Duration ,Pathway Analysis ,Genome-Wide Association Study ,Demography - Abstract
STUDY OBJECTIVES: Low or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits.METHODS: We performed a population-based molecular genetic study, using data form the EArly Genetics and Life course Epidemiology (EAGLE) Consortium. 10,554 children of European ancestry were included in the discovery, and 1,250 children in the replication phase.RESULTS: We found evidence of significant but modest SNP heritability of sleep duration in children (SNP h(2) 0.14, 95% CI [0.05, 0.23]) using the LD score regression method. A novel region at chromosome 11q13.4 (top SNP: rs74506765, P = 2.27e-08) was associated with sleep duration in children, but this was not replicated in independent studies. Nominally significant genetic overlap was only found (rG = 0.23, P = 0.05) between sleep duration in children and type 2 diabetes in adults, supporting the hypothesis of a common pathogenic mechanism.CONCLUSIONS: The significant SNP heritability of sleep duration in children and the suggestive genetic overlap with type 2 diabetes support the search for genetic mechanisms linking sleep duration in children to multiple outcomes in health and disease.
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- 2016
14. Erratum
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Pappa, Irene, Fedko, Iryna O., Mileva-Seitz, Viara R., Hottenga, Jouke Jan, Bakermans-Kranenburg, Marian J., Bartels, Meike, Van Beijsterveldt, Catharina E.M., Jaddoe, Vincent W.V., Middeldorp, Christel M., Rippe, Ralph C.A., Rivadeneira, Fernando, Tiemeier, Henning, Verhulst, Frank C., Van IJzendoorn, Marinus H., Boomsma, Dorret I., Clinical Child and Family Studies, LEARN! - Child rearing, Biological Psychology, EMGO+ - Mental Health, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, Educational and Family Studies, and APH - Mental Health
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- 2015
15. Changes in face-specific neural processing explain reduced cuteness and approachability of infants with cleft lip
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Huffmeijer, Renske, primary, Eilander, Janna, additional, Mileva-Seitz, Viara R., additional, and Rippe, Ralph C. A., additional
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- 2017
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16. Mild perinatal adversities moderate the association between maternal harsh parenting and hair cortisol: Evidence for differential susceptibility
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Windhorst, Dafna A., primary, Rippe, Ralph C.A., additional, Mileva‐Seitz, Viara R., additional, Verhulst, Frank C., additional, Jaddoe, Vincent W.V., additional, Noppe, Gerard, additional, van Rossum, Elisabeth F.C., additional, van den Akker, Erica L.T., additional, Tiemeier, Henning, additional, van IJzendoorn, Marinus H., additional, and Bakermans‐Kranenburg, Marian J., additional
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- 2017
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17. A genome-wide approach to children's aggressive behavior : The EAGLE consortium.
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Pappa, Irene, St Pourcain, Beate, Benke, Kelly, Cavadino, Alana, Hakulinen, Christian, Nivard, Michel G, Nolte, Ilja M, Tiesler, Carla M T, Bakermans-Kranenburg, Marian J, Davies, Gareth E, Evans, David M, Geoffroy, Marie-Claude, Grallert, Harald, Groen-Blokhuis, Maria M, Hudziak, James J, Kemp, John P, Keltikangas-Järvinen, Liisa, McMahon, George, Mileva-Seitz, Viara R, Motazedi, Ehsan, Power, Christine, Raitakari, Olli T, Ring, Susan M, Rivadeneira, Fernando, Rodriguez, Alina, Scheet, Paul A, Seppälä, Ilkka, Snieder, Harold, Standl, Marie, Thiering, Elisabeth, Timpson, Nicholas J, Veenstra, René, Velders, Fleur P, Whitehouse, Andrew J O, Smith, George Davey, Heinrich, Joachim, Hypponen, Elina, Lehtimäki, Terho, Middeldorp, Christel M, Oldehinkel, Albertine J, Pennell, Craig E, Boomsma, Dorret I, Tiemeier, Henning, Pappa, Irene, St Pourcain, Beate, Benke, Kelly, Cavadino, Alana, Hakulinen, Christian, Nivard, Michel G, Nolte, Ilja M, Tiesler, Carla M T, Bakermans-Kranenburg, Marian J, Davies, Gareth E, Evans, David M, Geoffroy, Marie-Claude, Grallert, Harald, Groen-Blokhuis, Maria M, Hudziak, James J, Kemp, John P, Keltikangas-Järvinen, Liisa, McMahon, George, Mileva-Seitz, Viara R, Motazedi, Ehsan, Power, Christine, Raitakari, Olli T, Ring, Susan M, Rivadeneira, Fernando, Rodriguez, Alina, Scheet, Paul A, Seppälä, Ilkka, Snieder, Harold, Standl, Marie, Thiering, Elisabeth, Timpson, Nicholas J, Veenstra, René, Velders, Fleur P, Whitehouse, Andrew J O, Smith, George Davey, Heinrich, Joachim, Hypponen, Elina, Lehtimäki, Terho, Middeldorp, Christel M, Oldehinkel, Albertine J, Pennell, Craig E, Boomsma, Dorret I, and Tiemeier, Henning
- Abstract
Individual differences in aggressive behavior emerge in early childhood and predict persisting behavioral problems and disorders. Studies of antisocial and severe aggression in adulthood indicate substantial underlying biology. However, little attention has been given to genome-wide approaches of aggressive behavior in children. We analyzed data from nine population-based studies and assessed aggressive behavior using well-validated parent-reported questionnaires. This is the largest sample exploring children's aggressive behavior to date (N = 18,988), with measures in two developmental stages (N = 15,668 early childhood and N = 16,311 middle childhood/early adolescence). First, we estimated the additive genetic variance of children's aggressive behavior based on genome-wide SNP information, using genome-wide complex trait analysis (GCTA). Second, genetic associations within each study were assessed using a quasi-Poisson regression approach, capturing the highly right-skewed distribution of aggressive behavior. Third, we performed meta-analyses of genome-wide associations for both the total age-mixed sample and the two developmental stages. Finally, we performed a gene-based test using the summary statistics of the total sample. GCTA quantified variance tagged by common SNPs (10-54%). The meta-analysis of the total sample identified one region in chromosome 2 (2p12) at near genome-wide significance (top SNP rs11126630, P = 5.30 × 10(-8) ). The separate meta-analyses of the two developmental stages revealed suggestive evidence of association at the same locus. The gene-based analysis indicated association of variation within AVPR1A with aggressive behavior. We conclude that common variants at 2p12 show suggestive evidence for association with childhood aggression. Replication of these initial findings is needed, and further studies should clarify its biological meaning. © 2015 Wiley Periodicals, Inc.
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- 2016
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18. Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium
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LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), dIRAS RA-2, Marinelli, Marcella, Pappa, Irene, Bustamante, Mariona, Bonilla, Carolina, Suarez, Anna, Tiesler, Carla M, Vilor-Tejedor, Natalia, Zafarmand, Mohammad Hadi, Alvarez-Pedrerol, Mar, Andersson, Sture, Bakermans-Kranenburg, Marian J, Estivill, Xavier, Evans, David M, Flexeder, Claudia, Fons, Joan, Gonzalez, Juan R, Guxens, Monica, Huss, Anke, van IJzendoorn, Marinus H, Jaddoe, Vincent W V, Julvez, Jordi, Lahti, Jari, López-Vicente, Mónica, Lopez-Espinosa, Maria-Jose, Manz, Judith, Mileva-Seitz, Viara R, Perola, Markus, Pesonen, Anu-Katriina, Rivadeneira, Fernando, Salo, Perttu P, Shahand, Shayan, Schulz, Holger, Standl, Marie, Thiering, Elisabeth, Timpson, Nicholas J, Torrent, Maties, Uitterlinden, André G, Smith, George Davey, Estarlich, Marisa, Heinrich, Joachim, Räikkönen, Katri, Vrijkotte, Tanja G M, Tiemeier, Henning, Sunyer, Jordi, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), dIRAS RA-2, Marinelli, Marcella, Pappa, Irene, Bustamante, Mariona, Bonilla, Carolina, Suarez, Anna, Tiesler, Carla M, Vilor-Tejedor, Natalia, Zafarmand, Mohammad Hadi, Alvarez-Pedrerol, Mar, Andersson, Sture, Bakermans-Kranenburg, Marian J, Estivill, Xavier, Evans, David M, Flexeder, Claudia, Fons, Joan, Gonzalez, Juan R, Guxens, Monica, Huss, Anke, van IJzendoorn, Marinus H, Jaddoe, Vincent W V, Julvez, Jordi, Lahti, Jari, López-Vicente, Mónica, Lopez-Espinosa, Maria-Jose, Manz, Judith, Mileva-Seitz, Viara R, Perola, Markus, Pesonen, Anu-Katriina, Rivadeneira, Fernando, Salo, Perttu P, Shahand, Shayan, Schulz, Holger, Standl, Marie, Thiering, Elisabeth, Timpson, Nicholas J, Torrent, Maties, Uitterlinden, André G, Smith, George Davey, Estarlich, Marisa, Heinrich, Joachim, Räikkönen, Katri, Vrijkotte, Tanja G M, Tiemeier, Henning, and Sunyer, Jordi
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- 2016
19. Beyond main effects of gene-sets: harsh parenting moderates the association between a dopamine gene-set and child externalizing behavior
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Windhorst, Dafna A., primary, Mileva-Seitz, Viara R., additional, Rippe, Ralph C. A., additional, Tiemeier, Henning, additional, Jaddoe, Vincent W. V., additional, Verhulst, Frank C., additional, van IJzendoorn, Marinus H., additional, and Bakermans-Kranenburg, Marian J., additional
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- 2016
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20. An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication
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Rijlaarsdam, Jolien, primary, Pappa, Irene, additional, Walton, Esther, additional, Bakermans-Kranenburg, Marian J., additional, Mileva-Seitz, Viara R., additional, Rippe, Ralph C.A., additional, Roza, Sabine J., additional, Jaddoe, Vincent W.V., additional, Verhulst, Frank C., additional, Felix, Janine F., additional, Cecil, Charlotte A.M., additional, Relton, Caroline L., additional, Gaunt, Tom R., additional, McArdle, Wendy, additional, Mill, Jonathan, additional, Barker, Edward D., additional, Tiemeier, Henning, additional, and van IJzendoorn, Marinus H., additional
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- 2016
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21. ASSOCIATION BETWEEN INFANT NIGHTTIME-SLEEP LOCATION AND ATTACHMENT SECURITY: NO EASY VERDICT
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Mileva-Seitz, Viara R., primary, Luijk, Maartje P.C.M., additional, van Ijzendoorn, Marinus H., additional, Bakermans-Kranenburg, Marian J., additional, Jaddoe, Vincent W.V., additional, Hofman, Albert, additional, Verhulst, Frank C., additional, and Tiemeier, Henning, additional
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- 2015
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22. Changes in face-specific neural processing explain reduced cuteness and approachability of infants with cleft lip.
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Huffmeijer, Renske, Eilander, Janna, Mileva-Seitz, Viara R., and Rippe, Ralph C. A.
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CLEFT lip ,CUTENESS (Aesthetics) ,INFANT diseases ,FACIAL abnormalities ,EVOKED potentials (Electrophysiology) - Abstract
The current study investigated whether changes in the neural processing of faces of infants with a facial abnormality - a cleft lip - mediate effects of the cleft lip on judgments of infant cuteness and approachability. Event-related potentials (ERPs) in response to pictures of faces of healthy infants and infants with a cleft lip, and ratings of cuteness and approachability of these infant faces, were obtained from 30 females. Infants with a cleft lip were rated as less attractive (less cute and approachable) than healthy infants, and both the N170 and P2 components of the ERP were of reduced amplitude in response to pictures of infants with a cleft lip. Importantly, decreased configural processing of infant faces with a cleft lip, as evidenced by reduced N170 amplitudes, mediated the reduced attractiveness ratings for infants with a cleft lip compared to healthy infants. Our findings help elucidate the mechanisms behind the less favorable responses to infants with a cleft lip, highlighting the role of face-specific rather than domain-general neural processes. [ABSTRACT FROM AUTHOR]
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- 2018
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23. A genome-wide approach to children's aggressive behavior:The EAGLE consortium
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Pappa, Irene, primary, St Pourcain, Beate, additional, Benke, Kelly, additional, Cavadino, Alana, additional, Hakulinen, Christian, additional, Nivard, Michel G., additional, Nolte, Ilja M., additional, Tiesler, Carla M. T., additional, Bakermans-Kranenburg, Marian J., additional, Davies, Gareth E., additional, Evans, David M., additional, Geoffroy, Marie-Claude, additional, Grallert, Harald, additional, Groen-Blokhuis, Maria M., additional, Hudziak, James J., additional, Kemp, John P., additional, Keltikangas-Järvinen, Liisa, additional, McMahon, George, additional, Mileva-Seitz, Viara R., additional, Motazedi, Ehsan, additional, Power, Christine, additional, Raitakari, Olli T., additional, Ring, Susan M., additional, Rivadeneira, Fernando, additional, Rodriguez, Alina, additional, Scheet, Paul A., additional, Seppälä, Ilkka, additional, Snieder, Harold, additional, Standl, Marie, additional, Thiering, Elisabeth, additional, Timpson, Nicholas J., additional, Veenstra, René, additional, Velders, Fleur P., additional, Whitehouse, Andrew J. O., additional, Smith, George Davey, additional, Heinrich, Joachim, additional, Hypponen, Elina, additional, Lehtimäki, Terho, additional, Middeldorp, Christel M., additional, Oldehinkel, Albertine J., additional, Pennell, Craig E., additional, Boomsma, Dorret I., additional, and Tiemeier, Henning, additional
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- 2015
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24. Beyond the usual suspects: a multidimensional genetic exploration of infant attachment disorganization and security
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Pappa, Irene, primary, Szekely, Eszter, additional, Mileva-Seitz, Viara R., additional, Luijk, Maartje P.C.M., additional, Bakermans-Kranenburg, Marian J., additional, van IJzendoorn, Marinus H., additional, and Tiemeier, Henning, additional
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- 2015
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25. Is parent–child bed-sharing a risk for wheezing and asthma in early childhood?
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Luijk, Maartje P.C.M., primary, Sonnenschein-van der Voort, Agnes M.M., additional, Mileva-Seitz, Viara R., additional, Jansen, Pauline W., additional, Verhulst, Frank C., additional, Hofman, Albert, additional, Jaddoe, Vincent W.V., additional, de Jongste, Johan C., additional, van IJzendoorn, Marinus H., additional, Duijts, Liesbeth, additional, and Tiemeier, Henning, additional
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- 2014
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26. Differential susceptibility in a developmental perspective: DRD4 and maternal sensitivity predicting externalizing behavior
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Windhorst, Dafna A., primary, Mileva‐Seitz, Viara R., additional, Linting, Mariëlle, additional, Hofman, Albert, additional, Jaddoe, Vincent W.V., additional, Verhulst, Frank C., additional, Tiemeier, Henning, additional, van IJzendoorn, Marinus H., additional, and Bakermans‐Kranenburg, Marian J., additional
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- 2014
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27. ASSOCIATION BETWEEN INFANT NIGHTTIME-SLEEP LOCATION AND ATTACHMENT SECURITY: NO EASY VERDICT.
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Mileva ‐ Seitz, Viara R., Luijk, Maartje P.C.M., van Ijzendoorn, Marinus H., Bakermans ‐ Kranenburg, Marian J., Jaddoe, Vincent W.V., Hofman, Albert, Verhulst, Frank C., and Tiemeier, Henning
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INFANT psychology , *SLEEP , *ATTACHMENT behavior , *MOTHER-infant relationship , *QUESTIONNAIRES , *ODDS ratio - Abstract
ABSTRACT We tested whether mother-infant bed-sharing is associated with increased secure infant-mother attachment, a previously unexplored association. Frequency of bed-sharing and mothers' nighttime comforting measures at 2 months were assessed with questionnaires in 550 Caucasian mothers from a population-based cohort. Attachment security was assessed with the Strange Situation Procedure (M.D.S. Ainsworth, M.C. Blehar, E. Waters, & S. Wall, 1978) at 14 months. When using a dichotomous variable, 'never bed-sharing' (solitary sleepers) versus 'any bed-sharing,' the relative risk of being classified as insecurely attached for solitary-sleeping infants (vs. bed-sharers) was 1.21 (95% confidence interval: 1.05-1.40). In multivariate models, solitary sleeping was associated with greater odds of insecure attachment, adjusted odds ratio (OR): 1.50, 95% CI = 1.02-2.20) and, in particular, with greater odds of resistant attachment, adjusted OR = 1.74, 95% CI = 1.10-2.76); and with a lower attachment security score, β = −0.12, t(495) = −2.61, p = .009. However, we found no evidence of a dose-response association between bed-sharing and secure attachment when using a trichotomous bed-sharing variable based on frequency of bed-sharing. Our findings demonstrate some evidence that solitary sleeping is associated with insecure attachment. However, the lack of a dose-response association suggests that further experimental study is necessary before accepting common notions that sharing a bed leads to children who are better or not better adjusted. [ABSTRACT FROM AUTHOR]
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- 2016
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28. Differential susceptibility in a developmental perspective: DRD4 and maternal sensitivity predicting externalizing behavior.
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Windhorst, Dafna A., Mileva‐Seitz, Viara R., Linting, Mariëlle, Hofman, Albert, Jaddoe, Vincent W.V., Verhulst, Frank C., Tiemeier, Henning, van IJzendoorn, Marinus H., and Bakermans‐Kranenburg, Marian J.
- Abstract
ABSTRACT This study is the first to investigate the longitudinal effects of gene-environment interplay between DRD4 genotype and maternal sensitivity on child externalizing behavior. Multiple measures of maternal sensitivity (14, 36, and 48 months) and externalizing behavior (18 months, 36 months, and 5 years) were assessed in a large cohort study ( N = 548). Early maternal insensitivity (14 months) was associated with early externalizing behavior (18 months) in a for better and for worse manner, but only in children with at least one DRD4 7-repeat, consistent with a differential susceptibility model. Later insensitivity (48 months) predicted externalizing behavior at age 5 independent of DRD4 genotype. A structural equation model including all measures across time supported the differential susceptibility model: The overall effect of early maternal sensitivity on later externalizing behavior was significant only for children with a DRD4 7-repeat allele. The results highlight the importance of studying gene-environment interactions across development. © 2014 Wiley Periodicals, Inc. Dev Psychobiol 57: 35-49, 2015. [ABSTRACT FROM AUTHOR]
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- 2015
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29. A visual aid for computer-based analysis of sleep–wake state in rats
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Mileva-Seitz, Viara R., primary, Louis, Rhain P., additional, and Stephenson, Richard, additional
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- 2005
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30. A genome-wide approach to children's aggressive behavior: the EAGLE consortium
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Pappa, Irene, St Pourcain, Beate, Benke, Kelly, Cavadino, Alana, Hakulinen, Christian, Nivard, Michel G., Nolte, Ilja M., Tiesler, Carla M. T., Bakermans-Kranenburg, Marian J., Davies, Gareth E., Evans, David M., Geoffroy, Marie-Claude, Grallert, Harald, Groen-Blokhuis, Maria M., Hudziak, James J., Kemp, John P., Keltikangas-Järvinen, Liisa, McMahon, George, Mileva-Seitz, Viara R., Motazedi, Ehsan, Power, Christine, Raitakari, Olli T., Ring, Susan M., Rivadeneira, Fernando, Rodriguez, Alina, Scheet, Paul A., Seppälä, Ilkka, Snieder, Harold, Standl, Marie, Thiering, Elisabeth, Timpson, Nicholas J., Veenstra, René, Velders, Fleur P., Whitehouse, Andrew J. O., Smith, George Davey, Heinrich, Joachim, Hypponen, Elina, Lehtimäki, Terho, Middeldorp, Christel M., Oldehinkel, Albertine J., Pennell, Craig E., Boomsma, Dorret I., Tiemeier, Henning, Pappa, Irene, St Pourcain, Beate, Benke, Kelly, Cavadino, Alana, Hakulinen, Christian, Nivard, Michel G., Nolte, Ilja M., Tiesler, Carla M. T., Bakermans-Kranenburg, Marian J., Davies, Gareth E., Evans, David M., Geoffroy, Marie-Claude, Grallert, Harald, Groen-Blokhuis, Maria M., Hudziak, James J., Kemp, John P., Keltikangas-Järvinen, Liisa, McMahon, George, Mileva-Seitz, Viara R., Motazedi, Ehsan, Power, Christine, Raitakari, Olli T., Ring, Susan M., Rivadeneira, Fernando, Rodriguez, Alina, Scheet, Paul A., Seppälä, Ilkka, Snieder, Harold, Standl, Marie, Thiering, Elisabeth, Timpson, Nicholas J., Veenstra, René, Velders, Fleur P., Whitehouse, Andrew J. O., Smith, George Davey, Heinrich, Joachim, Hypponen, Elina, Lehtimäki, Terho, Middeldorp, Christel M., Oldehinkel, Albertine J., Pennell, Craig E., Boomsma, Dorret I., and Tiemeier, Henning
- Abstract
Individual differences in aggressive behavior emerge in early childhood and predict persisting behavioral problems and disorders. Studies of antisocial and severe aggression in adulthood indicate substantial underlying biology. However, little attention has been given to genome-wide approaches of aggressive behavior in children. We analyzed data from nine population-based studies and assessed aggressive behavior using well-validated parent-reported questionnaires. This is the largest sample exploring children's aggressive behavior to date (N = 18,988), with measures in two developmental stages (N = 15,668 early childhood and N = 16,311 middle childhood/early adolescence). First, we estimated the additive genetic variance of children's aggressive behavior based on genome-wide SNP information, using genome-wide complex trait analysis (GCTA). Second, genetic associations within each study were assessed using a quasi-Poisson regression approach, capturing the highly right-skewed distribution of aggressive behavior. Third, we performed meta-analyses of genome-wide associations for both the total age-mixed sample and the two developmental stages. Finally, we performed a gene-based test using the summary statistics of the total sample. GCTA quantified variance tagged by common SNPs (10–54%). The meta-analysis of the total sample identified one region in chromosome 2 (2p12) at near genome-wide significance (top SNP rs11126630, P = 5.30 × 10−8). The separate meta-analyses of the two developmental stages revealed suggestive evidence of association at the same locus. The gene-based analysis indicated association of variation within AVPR1A with aggressive behavior. We conclude that common variants at 2p12 show suggestive evidence for association with childhood aggression. Replication of these initial findings is needed, and further studies should clarify its biological meaning. © 2015 Wiley Periodicals, Inc.
31. Preschool Children Without 7-repeat DRD4 Gene More Likely to Develop Disorganized Attachment Style.
- Author
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Graffi, Justin, Moss, Ellen, Jolicoeur-Martineau, Alexis, Moss, Gal, Lecompte, Vanessa, Pascuzzo, Katherine, Babineau, Vanessa, Gordon-Green, Cathryn, Mileva-Seitz, Viara R., Minde, Klaus, Sassi, Roberto, Carrey, Normand, Kennedy, James L., Gaudreau, Helene, Levitan, Robert, Meaney, Michael, and Wazana, Ashley
- Subjects
- *
ATTACHMENT behavior in children , *CHILD psychology , *DEPRESSION in children , *DOPAMINE receptors , *GENETIC polymorphisms , *LOW birth weight , *PATHOLOGICAL psychology , *PSYCHOLOGY - Abstract
Background: A disorganized attachment style is characterized by fearful and disoriented behaviours when a child is separated from their caregiver. Its presence is an early predictor of the later development of psychopathology, including depression. This study seeks to determine the effects of one environmental factor - the incidence of low birth weight - and one genetic factor - the presence of the long (7-repeat) polymorphism of the dopamine D4 receptor (DRD4) gene - on the development of disorganized attachment between the child and the mother. Methods: We sampled 251 mother-child dyads from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) project. We measured birth weight and DRD4 genotype, and assessed attachment style using modified separation-reunion procedure. Results: Birth weight did not have a significant effect on disorganized attachment (b=-0.001, t(230)=0.006, p=0.910). Presence of DRD4 7-repeat polymorphism had a significant negative effect on presence of disorganized attachment style (b=-1.196, t(230)=0.411, p=0.004). Conclusion: Children without the DRD4 7-repeat allele were more likely to display a disorganized attachment style compared to children with the DRD4 7-repeat allele. This indicates that the 7-repeat allele of the DRD4 gene may serve as a protective factor against disorganized attachment. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
32. Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium.
- Author
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Marinelli M, Pappa I, Bustamante M, Bonilla C, Suarez A, Tiesler CM, Vilor-Tejedor N, Zafarmand MH, Alvarez-Pedrerol M, Andersson S, Bakermans-Kranenburg MJ, Estivill X, Evans DM, Flexeder C, Forns J, Gonzalez JR, Guxens M, Huss A, van IJzendoorn MH, Jaddoe VW, Julvez J, Lahti J, López-Vicente M, Lopez-Espinosa MJ, Manz J, Mileva-Seitz VR, Perola M, Pesonen AK, Rivadeneira F, Salo PP, Shahand S, Schulz H, Standl M, Thiering E, Timpson NJ, Torrent M, Uitterlinden AG, Smith GD, Estarlich M, Heinrich J, Räikkönen K, Vrijkotte TG, Tiemeier H, and Sunyer J
- Subjects
- Adolescent, Child, Child, Preschool, Cohort Studies, Diabetes Mellitus, Type 2 epidemiology, Diabetes Mellitus, Type 2 genetics, Female, Humans, Longitudinal Studies, Male, Time Factors, White People genetics, Genome-Wide Association Study methods, Polymorphism, Single Nucleotide genetics, Quantitative Trait, Heritable, Sleep genetics
- Abstract
Study Objectives: Low or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits., Methods: We performed a population-based molecular genetic study, using data form the EArly Genetics and Life course Epidemiology (EAGLE) Consortium. 10,554 children of European ancestry were included in the discovery, and 1,250 children in the replication phase., Results: We found evidence of significant but modest SNP heritability of sleep duration in children (SNP h
2 0.14, 95% CI [0.05, 0.23]) using the LD score regression method. A novel region at chromosome 11q13.4 (top SNP: rs74506765, P = 2.27e-08) was associated with sleep duration in children, but this was not replicated in independent studies. Nominally significant genetic overlap was only found ( rG = 0.23, P = 0.05) between sleep duration in children and type 2 diabetes in adults, supporting the hypothesis of a common pathogenic mechanism., Conclusions: The significant SNP heritability of sleep duration in children and the suggestive genetic overlap with type 2 diabetes support the search for genetic mechanisms linking sleep duration in children to multiple outcomes in health and disease., (© 2016 Associated Professional Sleep Societies, LLC.)- Published
- 2016
- Full Text
- View/download PDF
33. A genome-wide approach to children's aggressive behavior: The EAGLE consortium.
- Author
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Pappa I, St Pourcain B, Benke K, Cavadino A, Hakulinen C, Nivard MG, Nolte IM, Tiesler CM, Bakermans-Kranenburg MJ, Davies GE, Evans DM, Geoffroy MC, Grallert H, Groen-Blokhuis MM, Hudziak JJ, Kemp JP, Keltikangas-Järvinen L, McMahon G, Mileva-Seitz VR, Motazedi E, Power C, Raitakari OT, Ring SM, Rivadeneira F, Rodriguez A, Scheet PA, Seppälä I, Snieder H, Standl M, Thiering E, Timpson NJ, Veenstra R, Velders FP, Whitehouse AJ, Smith GD, Heinrich J, Hypponen E, Lehtimäki T, Middeldorp CM, Oldehinkel AJ, Pennell CE, Boomsma DI, and Tiemeier H
- Subjects
- Adolescent, Aggression psychology, Behavior, Child, Female, Genetic Association Studies methods, Genetic Predisposition to Disease genetics, Genetic Variation, Genetics, Behavioral methods, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide genetics, Receptors, Vasopressin genetics, Receptors, Vasopressin physiology, Surveys and Questionnaires, Aggression physiology
- Abstract
Individual differences in aggressive behavior emerge in early childhood and predict persisting behavioral problems and disorders. Studies of antisocial and severe aggression in adulthood indicate substantial underlying biology. However, little attention has been given to genome-wide approaches of aggressive behavior in children. We analyzed data from nine population-based studies and assessed aggressive behavior using well-validated parent-reported questionnaires. This is the largest sample exploring children's aggressive behavior to date (N = 18,988), with measures in two developmental stages (N = 15,668 early childhood and N = 16,311 middle childhood/early adolescence). First, we estimated the additive genetic variance of children's aggressive behavior based on genome-wide SNP information, using genome-wide complex trait analysis (GCTA). Second, genetic associations within each study were assessed using a quasi-Poisson regression approach, capturing the highly right-skewed distribution of aggressive behavior. Third, we performed meta-analyses of genome-wide associations for both the total age-mixed sample and the two developmental stages. Finally, we performed a gene-based test using the summary statistics of the total sample. GCTA quantified variance tagged by common SNPs (10-54%). The meta-analysis of the total sample identified one region in chromosome 2 (2p12) at near genome-wide significance (top SNP rs11126630, P = 5.30 × 10(-8) ). The separate meta-analyses of the two developmental stages revealed suggestive evidence of association at the same locus. The gene-based analysis indicated association of variation within AVPR1A with aggressive behavior. We conclude that common variants at 2p12 show suggestive evidence for association with childhood aggression. Replication of these initial findings is needed, and further studies should clarify its biological meaning. © 2015 Wiley Periodicals, Inc., (© 2015 Wiley Periodicals, Inc.)
- Published
- 2016
- Full Text
- View/download PDF
34. Is parent-child bed-sharing a risk for wheezing and asthma in early childhood?
- Author
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Luijk MP, Sonnenschein-van der Voort AM, Mileva-Seitz VR, Jansen PW, Verhulst FC, Hofman A, Jaddoe VW, de Jongste JC, van IJzendoorn MH, Duijts L, and Tiemeier H
- Subjects
- Adult, Age Factors, Child, Child, Preschool, Cohort Studies, Female, Humans, Infant, Male, Netherlands epidemiology, Parents, Prospective Studies, Respiratory Tract Infections epidemiology, Respiratory Tract Infections etiology, Risk Factors, Asthma diagnosis, Asthma epidemiology, Asthma etiology, Bedding and Linens adverse effects, Bedding and Linens statistics & numerical data, Crowding
- Abstract
Household crowding can place young children at risk for respiratory infections which subsequently provoke asthma symptoms. However, crowding might also protect against asthma, in accordance with the hygiene hypothesis. We tested if parent-infant bed-sharing, an important dimension of household crowding, increases or decreases the risk for asthma. In a population-based prospective cohort (N = 6160) we assessed bed-sharing at 2 and 24 months; wheezing between 1 and 6 years of age; and asthma at 6 years of age. Generalised estimating equation models were used to assess repeated measures of wheezing and asthma. We found no association between bed-sharing in early infancy and wheezing or diagnosis of asthma. By contrast, we found a positive association between bed-sharing in toddlerhood and both wheezing (OR 1.42, 95% CI 1.15-1.74) and asthma (OR 1.57, 95% CI 1.03-2.38). Wheezing was not associated with bed-sharing when using cross-lagged modelling. This study suggests that bed-sharing in toddlerhood is associated with an increased risk of asthma at later ages, and not vice versa. Further studies are needed to explore the underlying causal mechanisms., (Copyright ©ERS 2015.)
- Published
- 2015
- Full Text
- View/download PDF
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