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Your search keyword '"Milazzo, Jean-Pierre"' showing total 12 results
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12 results on '"Milazzo, Jean-Pierre"'

12. [Cryopreservation of testicular tissue in children].

Author

Rives N, Milazzo JP, Travers A, Arkoun B, Bironneau A, Sibert L, Liard-Zmuda A, Marie-Cardine A, Schneider P, Vannier JP, and Macé B

Subjects
Adolescent, Animals, Antineoplastic Agents adverse effects, Child, Child, Preschool, Humans, Infant, Infertility, Male etiology, Male, Neoplasms therapy, Radiotherapy adverse effects, Seminiferous Tubules, Spermatogonia, Testis drug effects, Testis radiation effects, Transplantation, Autologous, Transplantation, Heterotopic, Cryopreservation methods, Fertility Preservation methods, Infertility, Male prevention & control, Replantation, Testis surgery
Abstract

The toxicity of cancer therapies can affect all organs and tissues. Some treatments damage spermatogonial stem cells (SSCs), with a risk of infertility. Storage and reimplantation of frozen testicular tissue is a recent approach tofertilitypreservationfor young boys. However, thawed frozen prepubertal testicular tissue must undergo a maturation process to restore sperm production. This process, currently being studied in animal models, can be achieved by in vivo transplantation of SSCs into seminiferous tubules or by testicular grafting, possibly following in vitro maturation.

Published
2013

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