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2. Effect of the Factor XIa Inhibitor Asundexian According to Baseline Infarct Pattern and on MRI Covert Infarct Outcomes

Author

Smith, Eric E., Shoamanesh, Ashkan, Xu, Lizhen, Heenan, Laura, Saad, Feryal, Colorado, Pablo, Chen, Chih-Hao, Lemmens, Robin, De Marchis, Gian Marco, Caso, Valeria, Masjuan, Jaime, Hirano, Teruyuki, Milanov, Ivan, Campbell, Bruce C.V., Mas, Jean-Louis, Connolly, Stuart J., Mundl, Hardi, Hart, Robert G., Bailey, P., Kleinig, T., Cordato, D., Choi, P., Garcia-Esperon, C., Chew, A., Cloud, G., Stanislaus, V., Krause, M., Priglinger, M., Grimley, R., Ghia, D., Sahathevan, R., Brown, H., Kwan, C., Devlin, M., Greisenegger, S., Bonelli-Nauer, S., Rath, J., Langer, A., Marko, M., Ferrari, J., Bernegger, A., Baumgartinger, M., Vigl, M., Krebs, S., Lang, W., Knoflach, M., Dejakum, B., Kiechl, S., Töll, T., Domig, L., Mutzenbach, J.S., Ganser, B., Hecker, C., Rösler, C., Bubel, N., Pikija, S., Zellner, T., Leitner, U., Berger, O., Surböck, B., Beirer, S., Staykov, D., Schrammel, D., Halilovic, A., Frattner, M., Barmherzigen, D., Lampl, C., Höfer, C., Nagl, S., Bocksrucker, C., Demeestere, J., Desfontaines, P., Ciobanu, C., De Pauw, A., Terwecoren, A., Hasenbroekx, M.C., Clement, F., De Klippel, N., Soors, P., Hermans, S., De Raedt, S., Vandervorst, F., Seynaeve, L., Fockaert, N., Smet, S., Rutgers, M., Del Gaudio, N., Paindeville, P., Staikov, I., Simeonova, A., Stoyanova, I., Cholakova, M., Mihnev, N., Petrova, T., Koralova, A., Dimov, D., Kuzev, Y., Danovska, M., Marinova, D., Marinova-Trifonova, D., Ovcharova, E., Mladenovski, I., Yanakieva, M., Stoev, P., Dimitrova, M., Todorova-Georgieva, S., Haralanov, L., Milkov, B., Solakov, D., Petkova, N., Ignatova-Valkova, V., Karabinov, V., Marinova, V., Miteva, Y., Andonova, V., Kasabova, D., Kostadinova, E., Shopova-Vrabcheva, Y., Gatev, D., Semova, D., Halil, E., Kaprelyan, A., Ivanov, B., Panov, G., Grudkova, M., Syuleyman, N., Kalpachki, R., Alexiev, F., Ivanova, I., Kancheva, K., Sakelarova, T., Maslarov, D., Drenska, D., Georgiev, V., Petrova, K., Petrova, N., Ivanova, I., Semerdjieva, N., Zhelyazkov, P., Spasova-Markova, S., Dong, X., Wang, D., Wang, S., Huang, W., Zhao, H., Wang, C., Jie, L., Xinyang, Y., Ping, Z., Dong, Q., Wang, Y., Fuling, Y., Yue, W., Liu, R., Yang, Y., Stetkarova, I., Mikulenka, P., Vasko, P., Peisker, T., Bar, M., Roubec, M., Mikulik, R., Cabukova, M., Vinklarek, J., Kovar, M., Pansky, M., Mencl, P., Skoda, O., Carek, M., Pernicka, M., Skodova, M., Geier, P., Cepkova, J., Drlik, J., Prax, T., Herzig, R., Krajickova, D., Vitkova, E., Haluskova, S., Vaclavik, D., Martinkova, J., Blejcharova, K., Tkacova, M., Pavlik, O., Nevšímalová, M., Rosol, J., Nevsimalova, M., Hruby, R., Iversen, H., Andersen, A.V., Rahimi, D., Christensen, H., Grundtvig, J., Hjort, N., Andersen, G., Sandal, B., Stilund, M., Modrau, B., Strade, A., Porobic, M., Andersen, S.D., Kruuse, C., Ölmestig, J., Kolmos, M., Parvez, A., Christensen, T., Stokholm, J., Jensen, H.B., Putaala, J., Strbian, D., Sibolt, G., Tiainen, M., Martinez-Majander, N., Curtze, S., Raty, S., Kraemer, Y., Roine, R., Aivo, J., Ruuskanen, J., Ylikotila, P., Roine, S., Hallikainen, M., Jakala, P., Kurl, S., Julkunen, V., Sibon, I., Olindo, S., Richard, S., Larrue, V., Gollion, C., Catala, H., Henon, H., Lucie, D.S., Nelly, D., Calvet, D., Malbranque, A., Mazé, B., Barbieux-Ghitu, C., Rosso, C., Samson, Y., Vannier, S., Moulin, T., Bonnet, L., Reiner, P., Buffon, F., Denier, C., Amri, K., Legris, N., Chassin, O., Selli, N., Mariana, S., Berrouschot, J., Stoll, A., Klunk, D., Keilitz, J., Neustadt, M., Zerrenner, S., Veltkamp, R., Hajjar, K., Heeger, A., Winezki, E., Apel, L., Pompsch, M., Mueller, P., Rappard, P., Auer, R., Ringleb, P.A., Berberich, A., Heyse, M., Mundiyanapurath, S., Reiff, T., Poli, S., Gomez-Exposito, A., Mengel, A., Tünnerhoff, J., Adeyemi, K., Poli, K., Kusch, V., Pelz, J., Michalski, D., Wartenberg, K., Althaus, K., Tavares, F., Mueller, S., Soda, H., Rascher, A., Hiermann, E., Weinhardt, R., Weissenborn, K., Leotescu, A., Grosse, G., Worthmann, H., Ernst, J., Gabriel, M., Schuppner, R., Schäfer, J.H., Charisse, D., Gruber, K., Kurka, N., Reitz, S.C., Pfeilschifter, W., Lee, J.I., Gliem, M., Moll, M., Steiner, T., Segura, L., Szegedi, N., Barandi, D., Uhrinakova, L., Czencz, M., Pasztor, M., Gyuker, N., Bartha, N.E., May, Z., Simony, Z., Szasz, G., Kakuk, I., Pető, N., Panczel, G.F., Olah, A., Racz, O., Balla, T., Horvath, B., Tuba, K., Czinderi, V., Klivenyi, P., Annus, A., Hertelendy, P., Szapary, L., Bosnyak, E., Kalmar, P., Karadi, Z., Cziba, L., Olah, L., Berki, A., Hudak, L., Kozák, M., Babel, S., Nemeth, L., Molnár, B., Simon, Z., Roveri, L., Cerri, F., Giacalone, G., Zini, A., Mauro, G., Asioli, G.M., Forlivesi, S., Arnone, G., Fiaccadori, A., Maria Fontana Francesca, E., Allegra, G., Mosconi, M.G., Longoni, M., Terlizzi, R., Paolucci, M., Tassi, R., Franci, B., Lucani, B., Domenichelli, C., Paoletti, D., Acampa, M., Zedde, M.L., Pezzella, F.R., Mangiardi, M., Galizia, P., Anticoli, S., Scalise, S., Lattanzi, S., Norata, D., Cannuccia, M., Cavallini, A., Federica, F., Denaro, M.F., Tosi, P., Sonoda, K., Kawajiri, M., Kusano, Y., Haraguchi, K., Kawano, H., Terasaki, T., Kaneko, C., Murase, S., Kumagai, M., Murai, N., Miyazaki, Y., Mori, T., Hatano, T., Kawanishi, M., Ochiai, J., Ishihara, S., Uehara, T., Yasaka, M., Nakagawa, H., Makino, M., Yonehara, T., Fukushima, Y., Hirotsune, N., Sakai, N., Yamasaki, M., Coutinho, J., Wouters, A., den Hertog, H., Zwartbol, R., Beumer, D., Kerklaan, J., Hilkens, P., Schreuder, T., Propper, D., Slowik, A., Wlodarczyk, E., Wrona, P., Pulyk, R., Lasek-Bal, A., Kosarz-Lanczek, K., Puz, P., Bilik, M., Magielska, A., Zamiela – Żółciak, A., Ochocinska, L., Bahdasaryan, S., Stępień, A., Dębiec, A., Joanna, K., Pawel, M., Jacek, S., Daniel, P., Marta, S., Rejdak, K., Wojczal, J., Luchowski, P., Fryze, W., Wisniewska, A., Krzyzanowska, M., Skowron, P., Wolosz, A., Galan, A., Grzymala, K., Krajewska, M., Nowak, R., Kłos, M., Cruz, V., Castro, P., Ferro, J., Canhão, P., Gouveia, R., Inácio, N., Rodrigues, M., Rachão, A., Ionel, C., Pereira, L., Viana-Baptista, M., Machado, C., Fernandes, C., Sargento, J., Inácio, N., Timchenko, L., Mironova, J., Zhadan, O., Torgashova, A., Bazhenova, O., Barashenkova, M., Kireeva, M., Romadina, N., Stepanova, I., Lenskaya, L., Lukinykh, L., Vorontsova, T., Agafina, A., Fedorova, A., Yashina, A., Alasheev, A., Smolkin, A., Prazdnichkova, E., Lutskovich, O., Gonysheva, Y., Mordvintseva, E., Nechaev, A., Martynova, E., Fedoraeva, N., Vishnyakova, T., Popov, D., Merzliakova, A., Margarita, K., Rechkalova, L., Ilyina, A., Kurenkova, N., Barbarash, O., Bazdyrev, E., Zvereva, T., Hromova, A., Morkvenas, A., Postnikova, E., Kovalenko, G., Taran, I., Pavlov, L., Ott, M., Chernitsova, N., Vodopyanova, N., Drozdova, E., Korebo, E., Lobanova, M., Lazareva, N., Snegova, N., Nikolaeva, O., Kolesnikov, Y., Kosheleva, Y., Krastev, G., Tomasova, K., Danis, M., Mako, M., Jankovicova, Z., Stevkova, Z., Kovacik, M., Kubikova, T., Jarosova, A., Serdahely, V., Cilingova, I., Pribulova, I., Sedlak, J., Slebodova, K., Paldaufova, M., Risnovsky, R., Berndtova, B., Urbanova, I., Junas, R., Karapetian, S., Gurcik, L., Vantrobova, A., Verbovsky, F., Vanacka, K., Ferenc, M., Galik, P., Bucakova, S., Ferencova, M., Kubalova, P., Boksanska, Z., Zacharova, E., Mahundi, E., Judita, H., Bachnak, M., Turcani, P., Kvasnicova Kamenska, A., Jurik, M., Vestenicka, V., Kycina, M., Sagatova, E., Dvorak, M., Hlubekova, A., Kucera, C., Gernath, L., Ferenc, M., Frimmelova, P., Slebodnikova, J., Aksteinerova, N., Horny, V., Gregova, Z., Segura, T., Romero, C., Ayo, O., Masjuan Vallejo, J., Cruz, A., De felipe, A, Matute, M.C., Garcia, S., Tembl Ferrairo, J., Vielba, I., Morales Caba, L., Molina, C., Garcia-Tornel García-Camba, Á., Requena Ruiz, M., Noelia, R., Rodriguez-Yañez, M., Rodriguez Castro, E., Lopez, I., Santamaria, M., Arias, S., Purroy García, F., Vázquez Justes, D., Mauri Capdevila, G., Vicente Pascual, M., Martí Fabregas, J., Camps Renom, P., Rodríguez Campello, A., Giralt, E., Krupinski, J., Molina, J., Trillo Senin, C. Ramos Martin, S., De La Fuente Sanz, E., Moniche, F., Manuel, M.R., Pardo, B., Martínez, I., Hernández Pérez, M., Arenillas Lara, J.F., De Lera, M., Egido, J.A., Gomez Escalonilla, C., Guillan, M., Martinez, J., Lindgren, A., Andsberg, G., Wictor, L., Leonidou, M., Stenman, M., Dalberg, N., Laska, A.C., Grünfeldt, A., Lundström, A., Nadzjafov, E., Rooth, E., Dalenbring, I., Sandén, P., Johansson, E., Thomas, G., Zietz, A.V., Rudin, S., Dittrich, T.D., Lilian, K., Kägi, G., Vehoff, J., Arnold, M., Scutelnic, A., Clénin, L., Beyeler, M., Madlaine, M., Maamari, B., Siepen, B., Vynckier, J., Tarnutzer, A., Bertschi, D., Luciani, M., Cereda, C., Maulucci, F., Bianco, G., Shairin, S., Pihan, H.A., Salmen, S., Quinn, T., McAlpine, C., Wright, F., Kalladka, D., Taylor, E., Sohaa, J., Brown, Z., Dawson, J., Cameron, A., Muir, S., Dima, S., Khan, U., Zhang, L., Warburton, E., Chatterjee, K., Nallasivan, A., Curran, D., Haider, S., Ghani, U., Kenton, A., Dallol, B., Mirza, M., Menezes, B., Davies, R., Robinson, T.G., Manning, L., Sztriha, L., Phinney, T., Sethi, P., Altafullah, I., Sharaf, A., Ostrander, M., Renati, S., Burgin, W.S., Olds, K., Delio, P., Malek, A., Dissin, J., Khatri, P., Flaherty, M., Demel, S., and Dofitas, S.

Published
2024
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3. Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial

Author

Shoamanesh, Ashkan, Mundl, Hardi, Smith, Eric E, Masjuan, Jaime, Milanov, Ivan, Hirano, Teruyuki, Agafina, Alina, Campbell, Bruce, Caso, Valeria, Mas, Jean-Louis, Dong, Qiang, Turcani, Peter, Christensen, Hanne, Ferro, Jose M, Veltkamp, Roland, Mikulik, Robert, De Marchis, Gian Marco, Robinson, Thompson, Lemmens, Robin, Stepien, Adam, Greisenegger, Stefan, Roine, Risto, Csiba, Laszlo, Khatri, Pooja, Coutinho, Jonathan, Lindgren, Arne G, Demchuk, Andrew M, Colorado, Pablo, Kirsch, Bodo, Neumann, Christoph, Heenan, Laura, Xu, Lizhen, Connolly, Stuart J, and Hart, Robert G

Published
2022
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5. Association between pain threshold and manifested pain assessed using a PD-specific pain scale in Parkinson's disease.

Author

Stoyanova-Piroth, Galina, Milanov, Ivan, and Stambolieva, Katerina

Subjects
PAIN threshold, PARKINSON'S disease, NOCICEPTIVE pain, PAIN measurement, MOVEMENT disorders
Abstract

Background: The neurodegenerative process in Parkinson's disease (PD) affects both dopaminergic and non-dopaminergic structures, which determine the wide range of motor and non-motor symptoms (NMS), including different types of pain. Diverse mechanisms contribute to pain in PD. Abnormal nociceptive processing is considered a distinctive feature of the disease. Objective: In the present study, we used a validated PD-specific pain assessment tool to investigate self-reported pain in PDpatients and to analyze the association with the objective pain threshold. Methods: The RIII component of the nociceptive flexor reflex was assessed in 35 patients with PD and was compared to 40 healthy controls. Self-reported pain was measured using the Bulgarian version of the King's Parkinson's Disease Pain Scale (KPPS-BG). A correlation analysis was used to investigate the relationship between the objective nociceptive threshold and PD pain as assessed by KPPS-BG. Results: PD patients had a significantly lower RIII threshold than control individuals (the mean SD value was 6.24 ± 1.39 vs. 10.33 ± 1.64) when assessed in the "off" state. A statistically significant (p < 0.05) fairly negative Spearman's correlation was observed between the decreased spinal nociceptive threshold and fluctuation-related pain (-0.31). Domain 4, "nocturnal pain" (-0.21), and the KPPS-BG total score (-0.21) showed a weak negative correlation. An insignificant positive correlation was found between domain 6--"discoloration, edema/swelling"--and the RIII threshold. A higher Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III score and modified Hoehn and Yahr (H&Y) scale are associated with a decreased nociceptive flexor reflex threshold. Conclusion: The results of the present study demonstrate the important role of increased spinal nociception in the occurrence of pain, which is associated with fluctuations and, to a lesser extent, nocturnal pain. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Consensus guidelines for botulinum toxin therapy: general algorithms and dosing tables for dystonia and spasticity

Author

Dressler, Dirk, Altavista, Maria Concetta, Altenmueller, Eckart, Bhidayasiri, Roongroj, Bohlega, Saeed, Chana, Pedro, Chung, Tae Mo, Colosimo, Carlo, Fheodoroff, Klemens, Garcia-Ruiz, Pedro J., Jeon, Beomseok, Jin, Lingjing, Kanovsky, Petr, Milanov, Ivan, Micheli, Federico, Orlova, Olga, Pandey, Sanjay, Pirtosek, Zvezdan, Relja, Maja, Rosales, Raymond, Sagástegui-Rodríguez, José Alberto, Shahidi, Gholam Ali, Timerbaeva, Sofia, Wan, Xinhua, Walter, Uwe, and Saberi, Fereshte Adib

Published
2021
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11. The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study

Author

Drulovic, Jelena, primary, Pekmezovic, Tatjana, additional, Tamas, Olivera, additional, Adamec, Ivan, additional, Aleksic, Dejan, additional, Andabaka, Marko, additional, Basic Kes, Vanja, additional, Butkovic Soldo, Silva, additional, Cukic, Mirjana, additional, Despinic, Livija, additional, Dincic, Evica, additional, Djelilovic Vranic, Jasminka, additional, Grgic, Sanja, additional, Habek, Mario, additional, Hristova, Sonya Ivanova, additional, Ivanovic, Jovana, additional, Jovanovic, Aleksa, additional, Jovicevic, Vanja, additional, Krbot Skoric, Magdalena, additional, Kuzmanovski, Igor, additional, Maric, Gorica, additional, Mesaros, Sarlota, additional, Milanov, Ivan Gospodinov, additional, Miletic Drakulic, Svetlana, additional, Sinanovic, Osman, additional, Skarpa Prpic, Ingrid, additional, Sremec, Josip, additional, Tadic, Daliborka, additional, Toncev, Gordana, additional, and Sokic, Dragoslav, additional

Published
2023
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13. Levodopa-carbidopa intestinal gel in advanced Parkinson's: Final results of the GLORIA registry

Author

Amalia, Ene, Arnold, Guy, Bajenaru, Ovidiu, Bergmans, Bruno, Bjornara, Kari Anne, Blackie, Jeff, Bode, Matthias, Bourgeois, Paul, Bohlhalter, Stephan, Buraga, Ioan, Burkhard, Pierre R., Busson, Philippe, Calopa, Matilde, Clausen, Jesper, Danielsen, Erik Hvid, Defebvre, Luc, Delvaux, Valerie, Dethy, Sophie, Dietrichs, Espen, De Fabregues, Oriol, Gerhard, Ransmayr, Gusmaroli, Graziano, Hahn, Kirsten, Hauptmann, Björn, Henriksen, Tove, Hernandez-Vara, Jorge, Jeanjean, A., Kaiserova, Michaela, Kassubek, Jan, Kimber, Thomas, Konitsiotis, Spyridon, Krüger, Rejko, Kulisevsky, Jaime, Leenders, Jo, Lundqvist, Christofer, Ory Magne, F., Marano, Pietro, Milanov, Ivan, Modugno, Nicola, Misbahuddin, Anjum, Nevrly, Martin, Panayiotis, Zikos, Pedersen, Kenn Freddy, Pedersen, Stephen W., Perju-Dumbrava, Lacramioara, Ponsen, M.M., Popescu, Bogdan O., Rijntjes, Michel, Puente, V., Redecker, Christoph, Schrader, Christoph, Sensi, Mariachiara, Simu, Mihaela, Spanaki, Cleanthe, Storch, Alexander, Storstein, Anette, Tomantschger, Volker, van der Linden, Chris, van Laar, T., Viallet, F., Witjas, Tatiana, Wolz, Martin, Zibetti, Maurizio, Van Zandijcke, Michel, Antonini, Angelo, Poewe, Werner, Chaudhuri, K. Ray, Jech, Robert, Pickut, Barbara, Pirtošek, Zvezdan, Szasz, Jozsef, Valldeoriola, Francesc, Winkler, Christian, Bergmann, Lars, Yegin, Ashley, Onuk, Koray, Barch, David, and Odin, Per

Published
2017
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14. A new approach for objective monitoring of the pharmacological-treatment response in recurrent depressions.

Author

Dimitrov, Rumen, Haralanova, Evelina, Milanov, Ivan, Ognyanov, Sava, Parvova, Iva, and Milushev, Emil

Subjects
MENTAL depression, PHARMACODYNAMICS, PSYCHOMOTOR disorders, PSYCHOPHARMACOLOGY, CLINICAL trials
Abstract

Depressive disorders are among the most important psychiatric problems. In everyday clinical practice, their symptoms and, respectively, their response to pharmacological treatment are both evaluated and measured subjectively. In the present paper, we apply a new approach for objective monitoring of the pharmacological-treatment response in patients with recurrent depressions. The applied method is user-friendly, easy-to-perform, and not time-consuming (1 test = 1 min), thus allowing repeatable examinations of many patients. The results show that the pre-treatment examination could discriminate between patients and healthy controls by revealing objectively measurable psychomotor retardation (in terms of locomotor hypo-activity and brady-reactivity) in the depressive group. After effective psychopharmacological treatment in a psychiatric clinic, the revealed psychomotor retardation is significantly improved (although not fully normalized) during the post-treatment examination at the time of discharge. The conclusion is that the new approach is reliable and sensitive enough to serve as a surrogate pharmacodynamic biomarker in patients with recurrent depressions. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Trigeminal Neuralgia

Author

Milanov, Ivan, Grozeva, Vesselina, Martelletti, Paolo, Series editor, Jensen, Rigmor, Series editor, Siva, Aksel, editor, and Lampl, Christian, editor

Published
2015
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19. COST-EFFECTIVENESS OF DISEASE-MODIFYING TREATMENTS FOR MULTIPLE SCLEROSIS IN BULGARIA BASED ON EVIDENCE FROM REAL WORLD SETTINGS.

Author

DIMITROVA, MARIA, SEITARIDOU, YOANA, LAZAROVA, RUMYANA, PETROVA, GUENKA, MITOV, KONSTANTIN, MILANOV, IVAN, MARINOV, LYUBOMIR, KAMUSHEVA, MARIA, and PANAYOTOV, PAVEL

Subjects
MULTIPLE sclerosis, COST effectiveness, MEDICAL care costs, GROSS domestic product
Abstract

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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20. Abstract WMP120: Development Of Smartphone Enabled Machine Learning Algorithms For Autonomous Stroke Detection

Author

Raychev, Radoslav I, primary, Saver, Jeffrey L, additional, Liebeskind, David S, additional, Penkov, Svetlin, additional, Angelov, Daniel, additional, Stoev, Krasimir, additional, Todorv, Todor, additional, Sakelarova, Teodora, additional, Kalpachka, Dobrinka, additional, Pelyova, Hristiana, additional, Ruseva, Rostislava, additional, Velcheva, Svetlana, additional, Kostadinova, Emanuela, additional, Dimov, Denislav, additional, Anna, Kolarova, additional, Manolova, Teodora, additional, Alexiev, Filip, additional, and Milanov, Ivan, additional

Published
2023
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23. Efficacy and safety of adjunctive padsevonil in adults with drug‐resistant focal epilepsy: Results from two double‐blind, randomized, placebo‐controlled trials

Author

Rademacher, Michael, primary, Toledo, Manuel, additional, Van Paesschen, Wim, additional, Liow, Kore K., additional, Milanov, Ivan G., additional, Esch, Maria‐Luise, additional, Wang, Nan, additional, MacPherson, Merran, additional, Byrnes, William J., additional, Minh, Timothy D. C., additional, Webster, Elizabeth, additional, and Werhahn, Konrad J., additional

Published
2022
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32. The development and use of the European academy of neurology guideline on palliative care in advanced progressive multiple sclerosis

Author

Solari, Alessandra, Giordano, Andrea, Garriga, Jaume Sastre, Kopke, Sascha, Rahn, Anne, Kleiter, Ingo, Aleksovska, Katina, Battaglia, Mario, Bay, Jette, Copetti, Massimiliano, Drulovic, Jelena, Kooij, Liesbeth, Mens, John, Murillo, Edwin Meza, Milanov, Ivan, Milo, Ron, Pekmezovic, Tatjana, Vosburgh, Janine, Silber, Eli, Veronese, Simone, Patti, Francesco, Voltz, Raymond, and Oliver, David

Published
2021
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33. Morphometry and Stiffness of Red Blood Cells—Signatures of Neurodegenerative Diseases and Aging

Author

Strijkova-Kenderova, Velichka, primary, Todinova, Svetla, additional, Andreeva, Tonya, additional, Bogdanova, Desislava, additional, Langari, Ariana, additional, Danailova, Avgustina, additional, Krumova, Sashka, additional, Zlatareva, Elena, additional, Kalaydzhiev, Nikolay, additional, Milanov, Ivan, additional, and Taneva, Stefka G., additional

Published
2021
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36. Structured Q1 headache services as the solution to the ill-health burden of headache: 1. Rationale and description

Author

Steiner, Timothy J. Jensen, Rigmor Katsarava, Zaza Stovner, Lars Jacob Uluduz, Derya Adarmouch, Latifa Al Jumah, Mohammed Al Khathaami, Ali M. Ashina, Messoud Braschinsky, Mark Broner, Susan Eliasson, Jon H. Gil-Gouveia, Raquel and Gomez-Galvan, Juan B. Gudmundsson, Larus S. Herekar, Akbar A. and Kawatu, Nfwama Kissani, Najib Kulkarni, Girish Baburao and Lebedeva, Elena R. Leonardi, Matilde Linde, Mattias and Luvsannorov, Otgonbayar Maiga, Youssoufa Milanov, Ivan and Mitsikostas, Dimos D. Musayev, Teymur Olesen, Jes Osipova, Vera Paemeleire, Koen Peres, Mario F. P. Quispe, Guiovanna and Rao, Girish N. Risal, Ajay de la Torre, Elena Ruiz and Saylor, Deanna Togha, Mansoureh Yu, Sheng-Yuan Zebenigus, Mehila Zewde, Yared Zenebe Zidverc-Trajkovic, Jasna Tinelli, Michela Global Campaign Against Headache

Abstract

In countries where headache services exist at all, their focus is usually on specialist (tertiary) care. This is clinically and economically inappropriate: most headache disorders can effectively and more efficiently (and at lower cost) be treated in educationally supported primary care. At the same time, compartmentalizing divisions between primary, secondary and tertiary care in many health-care systems create multiple inefficiencies, confronting patients attempting to navigate these levels (the “patient journey”) with perplexing obstacles. High demand for headache care, estimated here in a needs-assessment exercise, is the biggest of the challenges to reform. It is also the principal reason why reform is necessary. The structured headache services model presented here by experts from all world regions on behalf of the Global Campaign against Headache is the suggested health-care solution to headache. It develops and refines previous proposals, responding to the challenge of high demand by basing headache services in primary care, with two supporting arguments. First, only primary care can deliver headache services equitably to the large numbers of people needing it. Second, with educational supports, they can do so effectively to most of these people. The model calls for vertical integration between care levels (primary, secondary and tertiary), and protection of the more advanced levels for the minority of patients who need them. At the same time, it is amenable to horizontal integration with other care services. It is adaptable according to the broader national or regional health services in which headache services should be embedded. It is, according to evidence and argument presented, an efficient and cost-effective model, but these are claims to be tested in formal economic analyses.

Published
2021

37. Structured Q1 headache services as the solution to the ill-health burden of headache:1. Rationale and description

Author

Steiner, Timothy J., Jensen, Rigmor, Katsarava, Zaza, Stovner, Lars Jacob, Uluduz, Derya, Adarmouch, Latifa, Al Jumah, Mohammed, Al Khathaami, Ali M., Ashina, Messoud, Braschinsky, Mark, Broner, Susan, Eliasson, Jon H., Gil-Gouveia, Raquel, Gómez-Galván, Juan B., Gudmundsson, Larus S., Herekar, Akbar A., Kawatu, Nfwama, Kissani, Najib, Kulkarni, Girish Baburao, Lebedeva, Elena R., Leonardi, Matilde, Linde, Mattias, Luvsannorov, Otgonbayar, Maiga, Youssoufa, Milanov, Ivan, Mitsikostas, Dimos D., Musayev, Teymur, Olesen, Jes, Osipova, Vera, Paemeleire, Koen, Peres, Mario F. P., Quispe, Guiovanna, Rao, Girish N., Risal, Ajay, de la Torre, Elena Ruiz, Saylor, Deanna, Togha, Mansoureh, Yu, Sheng-Yuan, Zebenigus, Mehila, Zewde, Yared Zenebe, Zidverc-Trajković, Jasna, and Tinelli, Michela

Subjects
services, Medizin, UNITED-STATES, UTILIZATION, DISEASE, TENSION-TYPE HEADACHE, Headache disorders, Medicine and Health Sciences, SYSTEMATIC ANALYSIS, NATIONAL BURDEN, Public health, Global Campaign against headache, Health-technology assessment, DISABILITY, Global, GLOBAL BURDEN, CARE, Primary care, Health policy, PREVALENCE, Campaign against headache, Needs assessment, MIGRAINE, Barriers to care, Service organization and delivery, Structured headache services, Structured headache
Abstract

In countries where headache services exist at all, their focus is usually on specialist (tertiary) care. This is clinically and economically inappropriate: most headache disorders can effectively and more efficiently (and at lower cost) be treated in educationally supported primary care. At the same time, compartmentalizing divisions between primary, secondary and tertiary care in many health-care systems create multiple inefficiencies, confronting patients attempting to navigate these levels (the “patient journey”) with perplexing obstacles. High demand for headache care, estimated here in a needs-assessment exercise, is the biggest of the challenges to reform. It is also the principal reason why reform is necessary. The structured headache services model presented here by experts from all world regions on behalf of the Global Campaign against Headache is the suggested health-care solution to headache. It develops and refines previous proposals, responding to the challenge of high demand by basing headache services in primary care, with two supporting arguments. First, only primary care can deliver headache services equitably to the large numbers of people needing it. Second, with educational supports, they can do so effectively to most of these people. The model calls for vertical integration between care levels (primary, secondary and tertiary), and protection of the more advanced levels for the minority of patients who need them. At the same time, it is amenable to horizontal integration with other care services. It is adaptable according to the broader national or regional health services in which headache services should be embedded. It is, according to evidence and argument presented, an efficient and cost-effective model, but these are claims to be tested in formal economic analyses. CA extern

Published
2021
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41. Repetitive Transcranial Magnetic Stimulation Over Two Target Areas, Sham Stimulation and Topiramate in The Treatment of Chronic Migraine

Author

Todorov, Vasil, Bogdanova, Dessislava, Tonchev, Pencho, and Milanov, Ivan

Subjects
chronic migraine rTMS
Abstract

Compared with the patients with episodic migraine those with chronic migraine (CM) have worst quality of life and more severe headache related disability. Topiramate is among the few preventive treatments available so far. We investigated the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1), left dorsolateral prefrontal cortex (lDLPFC), sham stimulation and topiramate for CM treatment. One hundred and thirty-seven patients were randomized into four groups. We evaluated the patients at baseline, in month 1 and in month 2 after treatment for change of the frequency of headache, symptomatic medication use, headache intensity (VAS) and the result on Headache Impact Test – 6. Compared to baseline there was significant improvement of all investigated headache characteristics in the groups with active treatment (rTMS M1, rTMS lDLPFC, topiramate) both in month 1 and 2. In month 1, the two real rTMS groups showed statistically significant improvement compared to sham stimulation. There were no significant differences between the two active rTMS groups and the topiramate group in month 1 or in month 2. There were no serious adverse events. High frequency rTMS over M1 and lDLPFC shows effectiveness for CM treatment. There are no significant differences between the two target regions. The most prominent effect is observed during the first month after stimulation.

Published
2020

42. ESO897156 Supplemental material - Supplemental material for Enhancing and accelerating stroke treatment in Eastern European region: Methods and achievement of the ESO EAST program

Author

Mikulík, Robert, Caso, Valeria, Bornstein, Natan M, Svobodová, Veronika, Pezzella, Francesca Romana, Grecu, Andreea, Simsic, Steven, Gdovinova, Zuzana, Członkowska, Anna, Mishchenko, Tamara S, Flomin, Yuriy, Milanov, Ivan G, Andonova, Silva, Tiu, Cristina, Arsovska, Anita, Budinčević, Hrvoje, Groppa, Stanislav A, Bereczki, Daniel, Kõrv, Janika, Kharitonova, Tatiana, and Vosko, Milan R

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, ESO897156 Supplemental material for Enhancing and accelerating stroke treatment in Eastern European region: Methods and achievement of the ESO EAST program by Robert Mikulík, Valeria Caso, Natan M Bornstein, Veronika Svobodová, Francesca Romana Pezzella, Andreea Grecu, Steven Simsic, Zuzana Gdovinova, Anna Członkowska, Tamara S Mishchenko, Yuriy Flomin, Ivan G Milanov, Silva Andonova, Cristina Tiu, Anita Arsovska, Hrvoje Budinčević, Stanislav A Groppa, Daniel Bereczki, Janika Kõrv, Tatiana Kharitonova and Milan R Vosko in European Stroke Journal

Published
2020
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43. Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial

Author

Krauss, Gregory L., Krauss, Gregory L., Klein, Pavel, Brandt, Christian, Lee, Sang Kun, Milanov, Ivan, Milovanović, Maja, Steinhoff, Bernhard J., Kamin, Marc, Krauss, Gregory L., Krauss, Gregory L., Klein, Pavel, Brandt, Christian, Lee, Sang Kun, Milanov, Ivan, Milovanović, Maja, Steinhoff, Bernhard J., and Kamin, Marc

Abstract

Background More than a third of patients with epilepsy are treatment resistant, and thus new, more effective therapies to achieve seizure freedom are needed. Cenobamate (YKP3089), an investigational antiepileptic drug, has shown broad-spectrum anticonvulsant activity in preclinical studies and seizure models. We aimed to evaluate the safety, efficacy, and tolerability of adjunctive cenobainate in patients with uncontrolled focal (partial)-onset epilepsy. Methods We did a multicentre, double-blind, randomised, placebo-controlled, dose-response study at 107 epilepsy and neurology centres in 16 countries. Adult patients (aged 18-70 years) with focal seizures despite treatment with 1-3 antiepileptic drugs were randomly assigned (1:1:1:1) via an interactive web response system, by block sizes of 4 within each country, to adjuvant once daily oral cenobamate at dose groups of 100 mg, 200 mg, or 400 mg, or placebo following an 8-week baseline assessment. Patients, investigators, and study personnel were masked to treatment assignment. The study included a 6-week titration phase and 12-week maintenance phase. The primary efficacy outcomes were percentage change in 28-day focal seizure frequency (focal aware motor, focal impaired awareness, or focal to bilateral tonic-clonic seizures) from baseline analysed in the modified intention-to-treat population (>= 1 dose and any post-baseline seizure data) and responder rates (a50% reduction) analysed in the maintenance phase population (>= 1 dose in the maintenance phase and any maintenance phase seizure data). The primary efficacy outcomes were analysed using a hierarchal step-down procedure comparing 200 mg versus placebo, 400 mg versus placebo, then 100 mg versus placebo. Safety and tolerability were compared descriptively across treatment groups for all randomised patients. This study is registered with ClinicalTrials.gov, number NCT01866111. Findings Between July 31, 2013, and June 22,2015,437 patients were randomly assigned to

Published
2020

44. EAN Guideline on Palliative Care of People with Severe, Progressive Multiple Sclerosis

Author

Solari, Alessandra, Giordano, Andrea, Sastre-Garriga, Jaume, Koepke, Sascha, Rahn, Anne C., Kleiter, Ingo, Aleksovska, Katina, Battaglia, Mario A., Bay, Jette, Copetti, Massimiliano, Drulovic, Jelena, Kooij, Liesbeth, Mens, John, Meza Murillo, Edwin R., Milanov, Ivan, Milo, Ron, Pekmezovic, Tatiana, Vosburgh, Janine, Silber, Eli, Veronese, Simone, Patti, Francesco, Voltz, Raymond, Oliver, David J., Solari, Alessandra, Giordano, Andrea, Sastre-Garriga, Jaume, Koepke, Sascha, Rahn, Anne C., Kleiter, Ingo, Aleksovska, Katina, Battaglia, Mario A., Bay, Jette, Copetti, Massimiliano, Drulovic, Jelena, Kooij, Liesbeth, Mens, John, Meza Murillo, Edwin R., Milanov, Ivan, Milo, Ron, Pekmezovic, Tatiana, Vosburgh, Janine, Silber, Eli, Veronese, Simone, Patti, Francesco, Voltz, Raymond, and Oliver, David J.

Abstract

Background and Purpose: Patients with severe, progressive multiple sclerosis (MS) have complex physical and psychosocial needs, typically over several years. Few treatment options are available to prevent or delay further clinical worsening in this population. The objective was to develop an evidence-based clinical practice guideline for the palliative care of patients with severe, progressive MS. Methods: This guideline was developed using the Grading of Recommendations Assessment, Development and Evaluation methodology. Formulation of the clinical questions was performed in the Patients-Intervention-Comparator-Outcome format, involving patients, carers and healthcare professionals (HPs). No uniform definition of severe MS exists: in this guideline, constant bilateral support required to walk 20 m without resting (Expanded Disability Status Scale score >6.0) or higher disability is referred to. When evidence was lacking for this population, recommendations were formulated using indirect evidence or good practice statements were devised. Results: Ten clinical questions were formulated. They encompassed general and specialist palliative care, advance care planning, discussing with HPs the patient's wish to hasten death, symptom management, multidisciplinary rehabilitation, interventions for caregivers and interventions for HPs. A total of 34 recommendations (33 weak, 1 strong) and seven good practice statements were devised. Conclusions: The provision of home-based palliative care (either general or specialist) is recommended with weak strength for patients with severe, progressive MS. Further research on the integration of palliative care and MS care is needed. Areas that currently lack evidence of efficacy in this population include advance care planning, the management of symptoms such as fatigue and mood problems, and interventions for caregivers and HPs.

Published
2020

45. Palliative care in multiple sclerosis: European guideline

Author

Solari, Alessandra, Oliver, David, Giordano, Andrea, Sastre-Garriga, Jaume, Koepke, Sascha, Rahn, Anne C., Kleiter, Ingo, Aleksovska, Katina, Battaglia, Mario A., Bay, Jette, Copetti, Massimiliano, Drulovic, Jelena, Kooij, Liesbeth, Mens, John, Meza Murillo, Edwin R., Milanov, Ivan, Milo, Ron, Pekmezovic, Tatjana, Vosburgh, Janine, Silber, Eli, Veronese, Simone, Patti, Francesco, Voltz, Raymond, Solari, Alessandra, Oliver, David, Giordano, Andrea, Sastre-Garriga, Jaume, Koepke, Sascha, Rahn, Anne C., Kleiter, Ingo, Aleksovska, Katina, Battaglia, Mario A., Bay, Jette, Copetti, Massimiliano, Drulovic, Jelena, Kooij, Liesbeth, Mens, John, Meza Murillo, Edwin R., Milanov, Ivan, Milo, Ron, Pekmezovic, Tatjana, Vosburgh, Janine, Silber, Eli, Veronese, Simone, Patti, Francesco, and Voltz, Raymond

Published
2020

48. Implementation and impact of headache guidelines

Author

Diener, Hans-Christoph, primary, Antoncai, Fabio, additional, Couturier, Emile, additional, Goadsby, Peter J, additional, Jensen, Rigmor, additional, M Láinez, Jose, additional, Lipton, Richard B, additional, Milanov, Ivan, additional, Mitsikostas, Dimos, additional, Sandor, Peter, additional, Schoenen, Jean, additional, Valade, Dominique, additional, and Wysocka-Bakowska, Maria, additional

Published
2010
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50. Palliative care in multiple sclerosis: European guideline

Author

Solari, Alessandra, primary, Oliver, David, additional, Solari, Alessandra, additional, Giordano, Andrea, additional, Sastre-Garriga, Jaume, additional, Köpke, Sascha, additional, Rahn, Anne C., additional, Kleiter, Ingo, additional, Aleksovska, Katina, additional, Battaglia, Mario A., additional, Bay, Jette, additional, Copetti, Massimiliano, additional, Drulovic, Jelena, additional, Kooij, Liesbeth, additional, Mens, John, additional, Meza Murillo, Edwin R., additional, Milanov, Ivan, additional, Milo, Ron, additional, Pekmezovic, Tatjana, additional, Vosburgh, Janine, additional, Silber, Eli, additional, Veronese, Simone, additional, Patti, Francesco, additional, and Voltz, Raymond, additional

Published
2020
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