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The growing concern about microorganism infections, especially hospital-acquired infections, has driven the demand for effective and safe agents in recent years. Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3 nanoparticles (Fe2O3 NPs), and chitosan hydrogel beads in different concentrations. The characteristics and composition of the prepared materials were investigated by various techniques such as XRD, FESEM, and FTIR. The results indicate that the nanocomposites are synthesized successfully, and each component is present in hydrogel matrixes. Then, their biomedical properties, including antibacterial, antifungal, and antioxidant activity, were examined. Our findings demonstrate that the antimicrobial activity of nanocomposites significantly depends on the concentration of each component and their chemical groups. It shows itself in the result of the inhibitory zone of all bacteria or fungi samples. The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3 (CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01). In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01). According to our findings, we can say that these materials are promising biomaterials for inhibiting some infectious bacteria and fungi.

Objective Over the past decades, TNIP1 has been identified as a strong risk locus in multiple genome-wide association studies (GWAS), spanning multiple populations and various autoimmune diseases. TNIP1 is a polyubiquitin-binding protein that works as a physiological inhibitor of NF-κB and maintains immune homeostasis. Some studies have confirmed that TNIP1 is downregulated in autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In the current study, for the first time, we evaluated the possible association between rs6889239 polymorphism in the TNIP1 gene with the risk and clinical characteristics of RA and SLE in the Iranian population. Method In this case–control study, 115 patients with RA, 115 patients with SLE, and 115 unrelated healthy subjects were enrolled to estimate rs6889239 genotypes with real-time PCR high resolution melting (HRM) method. Results Our results demonstrated considerable associations between CC genotype and C allele of rs6889239 with augmented risk of SLE (OR for CC genotype= 2.23; 95%CI [1.175–4.307], OR for C allele= 1.84; 95%CI [1.254–2.720]). However, there was an insignificant association between genotypes and allele frequencies of rs6889239 with the occurrence risk of RA in the population under study ( p > 0.05). Additionally, stratification analysis specified that the C allele in rs6889239 was linked with the incidence of renal involvement in SLE patients and lower age of onset in the RA group ( p < 0.05). Conclusion These findings propose a significant association between TNIP1 polymorphism and higher risk of SLE and some clinical characteristics of RA and SLE.

Preeclampsia (PE) is a major complication of pregnancy and remains a leading cause of neonatal and maternal mortality worldwide. Several studies have revealed that the incidence of preeclampsia is high in mothers who carried a fetus with Rubinstein-Taybi Syndrome due to the mutation in CREBBP. We aimed to compare the expression level of the CERBBP gene between preeclamptic and healthy placenta in our study. The expression level of CREBBP gene was evaluated in a total of one hundred placental biopsies from PE patients and healthy pregnant women after delivery using quantitative real-time polymerase chain reaction (qRT-PCR). Moreover, the differential expression of CREBBP was assessed between the maternal and fetal sides of the placenta. Expression of the CREBBP gene was higher in preeclampsia patients compared with the controls (Fold change = 2.158; P = 0.018). Moreover, the gene expression was slightly higher in the fetal side of the placenta, although it was not significantly different (Fold change = 1.713, P = 0.254). Our findings show a role for CREBBP in the pathogenesis of PE. Due to the important role of CREBBP in angiogenesis and hypoxia, the gene may serve as a promising target in future studies.

Objective: To investigate the possible association of lncRNA HOTAIR rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. Method: The study subjects in...

Infantile neuroaxonal dystrophy is an autosomal recessive neurological disorder. Individuals with infantile neuroaxonal dystrophy experience progressive loss of vision, mental skills and muscular control, and other variable clinical signs. Pathogenic variants in the PLA2G6 gene, encoding phospholipase A2, are recognized to be the fundamental reason for infantile neuroaxonal dystrophy. This study aimed to detect pathogenic variant in a consanguine Iranian family with infantile neuroaxonal dystrophy.The mutation screening was done by whole exome sequencing followed by direct Sanger sequencing.We identified a homozygous insertion mutation, NM_003560: c.1548_1549insCG (p.G517Rfs*29) in exon 10 of PLA2G6 in the patient. The parents were heterozygous for variant.Because of the clinical heterogeneity and rarity of infantile neuroaxonal dystrophy, whole exome sequencing is critical to confirm the diagnosis and is an excellent tool for INAD management.

This paper proposes a certainty equivalence model predictive control (MPC) approach for the operation of islanded microgrids with a very high share of renewable energy sources. First, to make the MG model more realistic, the conversion losses of the storage units and the conversion losses of the power electronic devices are considered by the quadratic functions in the dynamic of units. Then, to mitigate the effect of errors in the storage units’ state of charge prediction, the conversion loss functions are reformulated by the mixed-integer linear inequality functions and included in the proposed scheme. Finally, the effectiveness of the proposed certainty MPC is verified by a numerical case study.

Biotinidase deficiency is an autosomal recessive inherited inborn error of biotin metabolism. Biotin as a water-soluble vitamin is the prosthetic group of biotin-dependent carboxylase enzymes, and by enhancing their function plays a key role in amino acid catabolism, fatty acid synthesis, and gluconeogenesis. Beyond its prosthetic group role, it has been recognized that biotin regulates the level of gene transcription in the eukaryotic cells, therefore any defect in these pathways causes a multisystem metabolic disorder characterized by neurological and cutaneous symptoms. We report the identification of a novel pathogenic variant in the BTD gene, c.528_542del15 (p.Asn197_Ser201del, UniProt P43251-1) in an Iranian consanguineous family with a severe form of the disease. The segregation analysis in the family was consistent with phenotype and the identified variant was predicated as a pathogenic mutation by the in-silico prediction tools. Computer structural modeling suggests the deleted amino acid residues are located near the biotinidase active site and disrupt the special conformations which are critical for the enzyme activity, and also N-glycosylation. This study further expands the mutation spectrum of the BTD gene underlying cause of profound biotinidase deficiency.

The mitochondrial damage has a pivotal role in triggering apoptosis and cell death. This study assessed the effect of silibinin on optical atrophy-1 (OPA1) and mitofusin-1 (MFN1) gene expression in liver tissue during hepatic warm ischemia-reperfusion (IR). Four groups of rats, eight rats each were designed: Vehicle: the rats received normal saline and encountered to laparotomy, Sili: silibinin (60 mg/kg) was administered to animals, IR: the rats received the normal saline and insulted by liver IR procedure, and IR + Sili: silibinin was injected to rats. All groups were subjected to the same process of injection of the solvent or silibinin (30 min before laparotomy or ischemia and immediately after the reperfusion), intraperitoneally (IP). After 3 h of reperfusion, blood and liver tissue samples were collected for future examinations. Our results showed no significant differences between the Vehicle and Sili groups in all assessed parameters. In IR + Sili, the increased serum levels of AST and ALT in comparison with the control group were markedly reduced by silibinin treatment. Silibinin lowered the elevated expression of OPA1 and MFN1 mRNAs in the IR group. Histology revealed silibinin could decline tissue degeneration compared to the IR group. Electron microscopy of control and silibinin groups showed no fusion of mitochondria and tissue degradation both of which were observed in the IR group. The extent of tissue destruction and mitochondrial fusion decreased significantly with silibinin treatment. Silibinin has a protective effect on liver cells against IR induced injuries by preserving mitochondrial membrane.

In this numerical study, natural flow and heat transfer of nanofluids with Al2O3, TiO2, Cu and CNT nanoparticles in a vertical channel with dimpled fins at Rayleigh number (Ra) of Ra = 3.25 × 107 to Ra = 1 × 108 are investigated by using the finite volume method. The obtained results revealed that, using CNT in volume fractions of 2% and 4% leads to significant heat transfer and at φ = 6%, using TiO2 nanoparticles has a great effect on Nu number enhancement. Also, using solid nanoparticles in base fluid causes more uniform heat transfer distribution, especially in areas close to heated surface and by adding more volume fraction in base fluid, temperature level reduces. In general, according to temperature contours, reduction of wall temperature depends on the increase of Ra and volume fraction and the type of solid nanoparticles.

Objective: Preeclampsia (PE) is a pregnancy hypertensive disorder that affects both maternal and fetal health. Many studies have investigated possible mechanisms in the pathogenesis of PE although the role of the placenta is undeniable. Evaluation of placental-specific microRNAs may provide additional data about the pathogenic mechanism of PE. This study compared the expression levels of Hsa-miR-517a/b in placental tissues obtained from PE patients and healthy controls. Material and Methods: One hundred tissues were obtained from fetal and maternal sides of the placenta of PE patients and healthy controls. Expression analysis was performed using quantitative real-time polymerase chain reaction. Results: Hsa-miR-517a/b level was significantly decreased in PE compared to controls (expression ratio: 0.40; p=0.007). Down-regulation of Hsa-miR-517a/b was also detected in fetal-side placental samples when compared to maternal-side in PE (expression ratio: 0.33; p=0.04). Furthermore, decreased expression of Hsa-miR-517a/b was detected in fetal-side tissue from PE cases compared to fetal-side samples from healthy pregnancies (expression ratio: 0.36; p=0.03). In maternal-side placental samples the expression level did not differ between PE and healthy pregnancies (p=0.1). Conclusion: These results demonstrate a differential expression of Hsa-miR-517a/b within placentas in pregnancies affected by PE and between placentas from PE and healthy pregnancies. Further studies are required to investigate a possible role for Hsa-miR-517a/b in the pathogenesis of PE.

Background Musculoskeletal disorders (MSDs) of the upper extremities and computer use are common in modern societies, and both show a growing trend. This study was conducted to determine the posture and 3D moments of wrist and elbow joints at different keyboard distances on a desk. Methods Twelve healthy right-handed male volunteers attended the motion analysis laboratory. A keyboard was placed at three different distances from the participants' bodies while performing a standard computer task. The workstation was adjusted according to ANSI/HFES-100-2007 standard for each participant to maintain comfortable ergonomic posture for controlling confounding variables. Qualisys motion capture system, OpenSim software (Ver. 4.1), and visual analog scale (VAS) were used to collect and analyze the data. Also, SPSS (Ver.16) was used to descriptive, Friedman and Wilcoxon tests. Results The highest levels of wrist flexion and radial deviation as well as elbow flexion and pronation were observed when the keyboard was at the edge of the desk. When the keyboard was 8 cm away from the edge of the desk, the wrist flexion, deviation, and pronation had the least values. With increasing the distance of the keyboard from the edge of the desk, the range of motion (ROM) of the wrist flexion and deviation as well as elbow flexion, supination and pronation decreased. The joint moments were not significantly different for the different studied keyboard positions (P-value > 0.05). Conclusions However, a cut-off point has to be specified because large keyboard distances cause high extension and flexion of the limbs. The position of the keyboard relative to the body is an important parameter in computer work and has a significant impact on the posture of the upper extremities. A keyboard should be located at a distance that allows the upper extremities to remain in a neutral position so that the risk of MSDs is reduced.

The increasing need for therapeutic monoclonal antibodies (mAbs) entails the development of innovative and improved expression strategies. Chromatin insulators have been utilized for the enhancement of the heterologous proteins in mammalian cells.In the current study the Ccnb1ip1 gene insulator element was utilized to construct a novel vector system for the expression of an anti-CD52 mAb in Chinese hamster ovary (CHO) cells. The insulator containing (pIns-mAb) and control (pmAb) vectors were generated and stable cell pools were established using these constructs. The expression level in the cells created with pIns-mAb vector was calculated to be 233 ng/mL, and the expression rate in the control vector was 210 ng/mL, which indicated a 10.9% increase in mAb expression in pIns-mAb pool. In addition, analysis of mAb expression in clonal cells established from each pool showed a 10% increase in antibody productivity in the highest mAb producing clone derived from the pIns-mAb pool compared to the clone isolated from pmAb pool.More studies are needed to fully elucidate the effects of Ccnb1ip1 gene insulator on recombinant therapeutic protein expression in mammalian cells. The combination of this element with other chromatin-modifying elements might improve its augmentation effect which could pave the way for efficient and cost-effective production of therapeutic drugs.

Acute lymphoid leukemia (ALL) is the largest subset of hematologic malignancies, accounting for approximately 70%-80% of childhood leukemia, and is most common at age 4 years. The aim of this study was to define the frequency of chromosomal abnormalities in pediatric ALL.In this 11-year retrospective study, we investigated 99 patients which referred to our department due to ALL from 2010 to 2020. The age group of the patients ranged from 6 months to 14 years with a mean of 6.71 ± 4.09 years. Clinical and diagnostic findings were extracted from patients' medical records.We showed cytogenetic abnormalities of 99 pediatric ALL patients, including 78 pre-B-ALL, 9 common B-ALL, and 12 T-ALL cases. The 5-year overall survival rate (OSR) and event-free survival (EFS) of all cytogenetic abnormalities (Our results emphasized the importance of the cytogenetic findings in evaluating the survival outcomes, which allows identifying a variety of OSR and EFS, because some of the cytogenetic abnormalities may interfere with the death and prognosis.

Preeclampsia (PE) is a major complication of pregnancy and remains a leading cause of neonatal and maternal mortality worldwide. Several studies have revealed that the incidence of preeclampsia is high in mothers who carried a fetus with Rubinstein-Taybi Syndrome due to the mutation in CREBBP. We aimed to compare the expression level of the CERBBP gene between preeclamptic and healthy placenta in our study. The expression level of CREBBP gene was evaluated in a total of one hundred placental biopsies from PE patients and healthy pregnant women after delivery using quantitative real-time polymerase chain reaction (qRT-PCR). Moreover, the differential expression of CREBBP was assessed between the maternal and fetal sides of the placenta. Expression of the CREBBP gene was higher in preeclampsia patients compared with the controls (Fold change = 2.158; P = 0.018). Moreover, the gene expression was slightly higher in the fetal side of the placenta, although it was not significantly different (Fold change = 1.713, P = 0.254). Our findings show a role for CREBBP in the pathogenesis of PE. Due to the important role of CREBBP in angiogenesis and hypoxia, the gene may serve as a promising target in future studies.

This paper focuses on solving the problem of voltage restoration in droop-controlled inverter-based islanded micro-grids (MGs) under communication delays. To this aim, we propose a novel robust distributed secondary controller which is the combination between an integral sliding mode controller and a linear consensus scheme with constant weights. Lyapunov analysis and Linear Matrix Inequalities (LMI) are employed together to demonstrate the associated stability and convergence features. The allowable upper bound for communication delays is also estimated by linear matrix inequalities. Regulating the MG’s voltages to the associated reference values additionally taken into account by developing an optimization algorithm to find the optimal constant control gains. Finally, simulation results show the effectiveness of the proposed solution.

Background Anterior cruciate ligament trauma is one of the most common knee injuries in professional athletes. This study aimed to investigate the effects of kinesio taping on kinesiophobia, balance, and functional performance in athletes after anterior cruciate ligament reconstruction. Methods This randomized, placebo-controlled clinical trial was performed on 20 athletes with anterior cruciate ligament reconstruction (mean age 32.3 ± 6.2 years) at the time of return to sport. The subjects were randomly assigned to the kinesio tape (KT) group (n = 10) or placebo KT group (n = 10). While subjects under taped, the following outcomes were measured at baseline, 10 minutes after the intervention, and 2 days later. Kinesiophobia, balance, strength, and functional / agility performance were assessed by the Tampa Scale, Y balance test (YBT), single-leg hops, and 10-yard extremity functional test, respectively. Results The results did not show a significant difference between-group post-intervention differences in kinesiophobia (Mean between-group difference = − 6.30, 95% CI = − 4.35 to 1.42, P-value = 0.17). Likewise, no significant statistical difference was observed between two study groups in terms of YBT scores (Mean between-group difference ranged over = − 6.30, 95% CI = − 1.1 to 4.7, the effect sizes ranged over = 0.01 to 0.31), P-value > 0.05), Single Leg Hop (Mean between-group difference = − 0.48, 95% CI for difference ranged over = − 10.3 to 9.3, effect size = 0.001, P-value = 0.918), and 10 Yard test scores (Mean between-group difference = − 0.30, 95% CI = (− 1.3 to 0.75), effect size = 0.02, P-value = 0.55) at 2 days after the KT. In the KT and placebo KT groups, RMANOVA indicated that the differences in all variables scores were significant over time with large effect sizes (effect size ranged over = 0.94–0.99; all P-value Conclusion This study gives no support for any beneficial effect of kinesio taping on the reduction of kinesiophobi or improvement of balance score and functional performance in athletes with post anterior cruciate ligament reconstruction. Trial registration This study was registered in the Iranian Clinical Trial Center with the code IRCT20190130042556N1, registered 12 February 2019.

This paper deals with the problem of voltage and frequency restoration in droop-controlled inverter-based islanded microgrids (MGs). The problem is solved using a novel tracking consensus secondary control protocol based on the sliding-mode approach, which not only guarantees the exact finite-time restoration among voltages and frequencies of an inverter-based islanded microgrid, but also preserves the active power sharing among distributed generations (DGs). For each distributed generator with no direct access to reference values, a finite-time distributed estimator is locally designed and implemented in each DG unit to provide the reference value of frequency and voltage in a finite time. Lyapunov analysis is employed to verify the associated stability and fast convergence time of the proposed controller. Finally, simulation results are are presented and analyzed to confirm the effectiveness of the proposed approach.

Background Wolfram's syndrome (WFS) is a hereditary (autosomal recessive) neurodegenerative disorder. The clinical features are related to diabetes insipidus, diabetes mellitus, optic atrophy, and deafness (DIDMOAD) with other variable clinical manifestations. Pathogenic variants in the WFS1 gene, encoding wolframin, are known to be the main cause of Wolfram's syndrome. In this study, we present the clinical and genetic characteristics of two WFS patients from an Iranian family. Methods The mutation screening was performed by polymerase chain reaction (PCR) followed by direct Sanger sequencing of all exons from two affected WFS. Results The complete Sanger sequencing of the WFS1 gene detected a homozygous missense variant, c.2207G>A (p.Gly736Asp), in the eighth exon of the WFS1 gene. Both cases developed all the major symptoms of the disease, interestingly, except hearing loss. Conclusions Because of the rarity and clinical heterogeneity of WFS, the molecular genetic assay is essential to confirm the diagnosis and management of the WFS patients.

Uterine leiomyoma (ULM) is the most common gynecological tumor. Recent studies have revealed the role of hypovitaminosis D as a major risk factor in the disease development. CYP24A, a mitochondrial enzyme that catalyzes the degradation of 1,25(OH)2D3, is reported to be over-expressed in several human cancers. In this study, we aimed to investigate the expression level of CYP24A1 in leiomyoma samples compared with the adjacent tissues regarding the MED12 mutation profile. In the present study, 61 ULMs and adjacent tissue samples were collected from 51 women undergoing hysterectomy and myomectomy. The samples were Sanger sequenced for MED12 mutation, and the expression level of CYP24A1 was evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). The results demonstrated that CYP24A1 gene was ectopically expressed in 18% of uterine leiomyoma tissues, although this expression was independent of the MED12 mutation profile. The findings of the present study support current evidence that dysregulation of vitamin D signaling and metabolic pathways may be involved in at least some subtypes of ULMs.

Background : This study aimed to investigate the effects of Kinesio Taping on Kinesiophobia (fear of re-injury), balance and functional performance in athletes after anterior cruciate ligament reconstruction. Methods: This randomized, placebo-controlled clinical trial was performed on 20 athletes with anterior cruciate ligament reconstruction (mean age 32.35 ± 6.25 years) at the time of return to sport. The participants were selected using purposive sampling approach and they were randomly assigned to kinesio tape group (n=10) or placebo kinesio tape group (n=10). While subjects under taped, the following outcomes were measured at baseline, ten minutes after the intervention, and two days later. Kinesiophobia, balance, strength, functional / agility performance was assessed by Tampa Scale, Y balance test (YBT), single leg hops and 10-yard extremity functional test, respectively. Data were analyzed using the repeated measure analysis of variance (RMANOVA) in the SPSS v.23. Results: Two days after Kinesio taping, the difference between the scores obtained in the first and the second measurements for all variables in the kinesio tape group was not significantly different rather than placebo kinesio tape group (all P> 0.05). The difference between scores of the third and the first measurements of all variables was also not significantly different in the kinesio tape group compared to the placebo kinesio tape group (all P> 0.05). In the kinesio tape and placebo kinesio tape groups, RMANOVA indicated that the differences in all variables scores were significant over time (P < 0.001), Sidak post-hoc test indicated that the differences between the first and the second measurements, as well as between the first and the third measurements were significant (P < 0.001). Conclusion: This study gives no support for any beneficial effect of kinesio taping on reduction of kinesiophobi or improvement of balance score and functional performance in athletes with post anterior cruciate ligament reconstruction. Trial registration: This study was registered in the Iranian Clinical Trial Center with the code IRCT20190130042556N1, https://www.irct.ir/trial/37312, registered 12 February 2019.

In this chapter, some recent results of applications of sliding-mode control strategies for solving the AC microgrid secondary restoration control problem are discussed. The control problem is formulated in a distributed way in accordance with the leader–follower consensus paradigm thus avoiding centralized decision-making. The control schemes are robust in the sense that the voltage and frequency restoration of an inverter-based islanded microgrid is achieved under severe uncertainties affecting the grid and load dynamical models and parameters. In this chapter, two distributed sliding-mode-based control strategies are discussed. The first approach performs the task in finite time exploiting instantaneous communications among distributed generators, whereas the second one attains the goal with an exponential convergence rate by taking into account delayed communications among generators. Both the proposed strategies yield continuous control actions, with discontinuous time derivative, that can safely be pulse-width modulated by a fixed-frequency carrier, as required to not hurt the switching power artifacts. The performance of the proposed schemes is analyzed by means of Lyapunov tools and verified by means of numerical simulations taken in different operative scenarios.

Background: This study aimed to investigate the effects of Kinesio Taping on Kinesiophobia (fear of re-injury), balance and functional performance in athletes after anterior cruciate ligament reconstruction.Methods: This randomized, placebo-controlled clinical trial was performed on 20 athletes with anterior cruciate ligament reconstruction (mean age 32.35 ± 6.25 years) at the time of return to sport. The participants were selected using purposive sampling approach and they were randomly assigned to kinesio tape group (n=10) or placebo kinesio tape group (n=10). While subjects under taped, the following outcomes were measured at baseline, ten minutes after the intervention, and two days later. Kinesiophobia, balance, strength, functional / agility performance was assessed by Tampa Scale, Y balance test (YBT), single leg hops and 10-yard extremity functional test, respectively. Data were analyzed using the repeated measure analysis of variance (RMANOVA) in the SPSS v.23.Results: Two days after Kinesio taping, the difference between the scores obtained in the first and the second measurements for all variables in the kinesio tape group was not significantly different rather than placebo kinesio tape group (all P> 0.05). The difference between scores of the third and the first measurements of all variables was also not significantly different in the kinesio tape group compared to the placebo kinesio tape group (all P> 0.05). In the kinesio tape and placebo kinesio tape groups, RMANOVA indicated that the differences in all variables scores were significant over time (P < 0.001), Sidak post-hoc test indicated that the differences between the first and the second measurements, as well as between the first and the third measurements were significant (P < 0.001).Conclusion: Kinesio taping reduced kinesiophobia and provided more improvement in balance, agility and functional performance of athletes with anterior cruciate ligament reconstruction, but these effects were too small to be clinically worthwhile. Trial registration: This study was registered in the Iranian Clinical Trial Center with the code IRCT20190130042556N1, https://www.irct.ir/trial/37312, registered 12 February 2019. Keywords: Kinesio tape, Anterior cruciate ligament reconstruction, Fear, Physical Functional Performance, Balance

In this study, laminar and steady flow of hybrid Al2O3–Cu/water nanofluid is done for volume fraction of solid nanoparticles 0–2% in a double-layered microchannel with sinusoidal walls. The results of this study show that the sinusoidal shape of the microchannel walls has a strong effect on increasing heat transfer, and increasing solid nanoparticle volume fraction in base fluid can have a significant difference for increasing Nusselt number, so that the value of Nusselt number for solid nanoparticles volume fraction of 2% for Re = 50, 300, 700 and 1200 experiences 23%, 22% 19% and 13% increase compared with the base fluid. By increasing fluid viscosity, the shear stress especially in the areas close to wall and in fluid layers is increased and this factor can increase pressure drop in higher solid nanoparticles volume fractions. The static temperature profiles are affected by hot surfaces and their sinusoidal shapes in lower Reynolds numbers, and the curve for temperature of flow centerline for Re = 700 and 1200 is straight lines. Therefore, the usage of it for Reynolds numbers above 700 is not recommended.