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1. 3-year results of the German nationwide survey on eye injuries caused by fireworks

Author

Gabel-Pfisterer, A., Boehringer, D., Agostini, H., Fuest, M., Walter, P., Botros, Y., Mueller, A., Al-Ashi, N., Lenglinger, M., Mueller, B., Schoenfeld, S., Seibel, I., Joussen, A., Breuss, H., Kuchenbecker, J., Foerster, M. H., Berthold, A., Wirbelauer, C., Hofmayer, H., Wachtlin, J., Palka, K., Niemeyer, M., Walla, T., Pham, D., Aisenbrey, S., Tatsiou, A., Walch, A., Burk, R., Schultz, T., Tsiampalis, N., Rehmann, J., Sliwowska, U., Schojai, M., Schulze, K., Kamguia, N., Wirtz, C., Dick, B., Voelker, D., Wintergerst, M., Pfau, M., Melzer, C., Hoegen, D., Bosch, F., Andresen, J. C., Krohne, T., Holz, F., Kathke, M., Sturm, A., Noske, W., Huebner, T., Brandner, S., Feldmann, M., Morsek, J., Rainer, O., Bartsch, H., Ewald, K., Chankiewitz, E., Siegmund, T., Bohlen, A., Mohr, A., Hecker, J., Strassburger, P., Furashova, O., Engelmann, K., Krieb, A., Emmerich, K., Grajewski, L., Krause, L., Jabur, A., Ruediger, K., Lehmann, F., Sachs, H., Matthee, E., Steindorf, F., Schnitzler, C., Neumann, I., Korbmacher, J., Geerling, G., Doulgkeridis, J., Erhard, J., Dahms-Dowidat, K., Kotiasvili, T., Jagow, B. V., Lieder, A., Blum, M., Westerkemper, H., Boehm, M., Bornfeld, N., Bechrakis, N., Schultheiss, M., Scheider, A., Mueller, M., Kohnen, T., Eckert, T., Eckardt, C., Wisniewska, M., Just, A., Jehle, V., Reinhard, T., Seewald, J., Mais, C., Basiakos, S., Osman, B., Xanthopoulou, E., Friedburg, B., Graef, M., Lorenz, B., Just, U., Naxer, S., Oterendorp, C., Bemme, S., Callizo, J., Feltgen, N., Hoerauf, H., Menges, A., Tost, F., Stahl, A., Huth, A., Viestenz, A., Bertram, P., Skevas, C., Kromer, R., Casagrande, M., Grohmann, C., Mehlan, J., Schindler, P., Spitzer, M., Schargus, M., Eddy, M., Schumacher, S., Keserue, M., Scheler, A., Stemplewitz, B., Schaudig, U., Abou Moulig, W., Framme, C., Rosenthal, A., Hesse, L., Kunz, L., Spira, C., Suffo, S., Seitz, B., Wietstock, G., Augsten, R., Meller, D., Mayer, M., Vanselow, K., Lieb, W., Beutner, A., Effert, R., Ehlken, C., Roider, J., Hueber, A., Cursiefen, K., Schrage, N., Kroeger, M., Viehweg, N., Meier, P., Unterlauft, J. D., Wiedemann, P., Hattenbach, L., Kakkassery, V., Ranjbar, M., Mohi, A., Grisanti, S., Bastron, I., Sarac, S., Kaskel-Paul, S., Stoffelns, B., Schuster, A., Pfeiffer, N., Schulze, S., Praskevas, A., Sekundo, W., Weigel, M., Thieme, H., Wolf, A., Vounotrypidis, E., Priglinger, S., Bechstein, L., Maier, M., Lohmann, C., Haritoglu, C., Alten, F., Eter, N., Klishko, V., Holland, U., Medra, A., Weber, A., Hoeh, H., Schmidbauer, J., RiveraGomez, C., Plantzas, K., Weiss, M., Hille, K., Hoehn, F., Schrader, M., Napholz, A., Tandogan, T., Walter, C., Zuehlsdorff-Uthke, M., Liekfeld, A., Blecha, C., Barth, T., Helbig, H., Juenemann, A., Decker, A., Kuehn, M., Ladewig, M., Lenhard, K., Lackner, B., Gekeler, F., Holzschuh, I., Boden, K. T., Szurmann, P., Faul, D., May-Endres, K., Press, U., Luttke, J., Ziemssen, F., Bartz-Schmidt, U., Cordes, J., Raber, F., Mikielewicz, M., Kammerer, J., Kupferschmid, S., Buchwald, H., Werner, J., Kampmeier, J., Bula, A., Krauss, P., Strzalkowski, P., Hillenkamp, J., Gabel-Pfisterer, A., Boehringer, D., Agostini, H., Fuest, M., Walter, P., Botros, Y., Mueller, A., Al-Ashi, N., Lenglinger, M., Mueller, B., Schoenfeld, S., Seibel, I., Joussen, A., Breuss, H., Kuchenbecker, J., Foerster, M. H., Berthold, A., Wirbelauer, C., Hofmayer, H., Wachtlin, J., Palka, K., Niemeyer, M., Walla, T., Pham, D., Aisenbrey, S., Tatsiou, A., Walch, A., Burk, R., Schultz, T., Tsiampalis, N., Rehmann, J., Sliwowska, U., Schojai, M., Schulze, K., Kamguia, N., Wirtz, C., Dick, B., Voelker, D., Wintergerst, M., Pfau, M., Melzer, C., Hoegen, D., Bosch, F., Andresen, J. C., Krohne, T., Holz, F., Kathke, M., Sturm, A., Noske, W., Huebner, T., Brandner, S., Feldmann, M., Morsek, J., Rainer, O., Bartsch, H., Ewald, K., Chankiewitz, E., Siegmund, T., Bohlen, A., Mohr, A., Hecker, J., Strassburger, P., Furashova, O., Engelmann, K., Krieb, A., Emmerich, K., Grajewski, L., Krause, L., Jabur, A., Ruediger, K., Lehmann, F., Sachs, H., Matthee, E., Steindorf, F., Schnitzler, C., Neumann, I., Korbmacher, J., Geerling, G., Doulgkeridis, J., Erhard, J., Dahms-Dowidat, K., Kotiasvili, T., Jagow, B. V., Lieder, A., Blum, M., Westerkemper, H., Boehm, M., Bornfeld, N., Bechrakis, N., Schultheiss, M., Scheider, A., Mueller, M., Kohnen, T., Eckert, T., Eckardt, C., Wisniewska, M., Just, A., Jehle, V., Reinhard, T., Seewald, J., Mais, C., Basiakos, S., Osman, B., Xanthopoulou, E., Friedburg, B., Graef, M., Lorenz, B., Just, U., Naxer, S., Oterendorp, C., Bemme, S., Callizo, J., Feltgen, N., Hoerauf, H., Menges, A., Tost, F., Stahl, A., Huth, A., Viestenz, A., Bertram, P., Skevas, C., Kromer, R., Casagrande, M., Grohmann, C., Mehlan, J., Schindler, P., Spitzer, M., Schargus, M., Eddy, M., Schumacher, S., Keserue, M., Scheler, A., Stemplewitz, B., Schaudig, U., Abou Moulig, W., Framme, C., Rosenthal, A., Hesse, L., Kunz, L., Spira, C., Suffo, S., Seitz, B., Wietstock, G., Augsten, R., Meller, D., Mayer, M., Vanselow, K., Lieb, W., Beutner, A., Effert, R., Ehlken, C., Roider, J., Hueber, A., Cursiefen, K., Schrage, N., Kroeger, M., Viehweg, N., Meier, P., Unterlauft, J. D., Wiedemann, P., Hattenbach, L., Kakkassery, V., Ranjbar, M., Mohi, A., Grisanti, S., Bastron, I., Sarac, S., Kaskel-Paul, S., Stoffelns, B., Schuster, A., Pfeiffer, N., Schulze, S., Praskevas, A., Sekundo, W., Weigel, M., Thieme, H., Wolf, A., Vounotrypidis, E., Priglinger, S., Bechstein, L., Maier, M., Lohmann, C., Haritoglu, C., Alten, F., Eter, N., Klishko, V., Holland, U., Medra, A., Weber, A., Hoeh, H., Schmidbauer, J., RiveraGomez, C., Plantzas, K., Weiss, M., Hille, K., Hoehn, F., Schrader, M., Napholz, A., Tandogan, T., Walter, C., Zuehlsdorff-Uthke, M., Liekfeld, A., Blecha, C., Barth, T., Helbig, H., Juenemann, A., Decker, A., Kuehn, M., Ladewig, M., Lenhard, K., Lackner, B., Gekeler, F., Holzschuh, I., Boden, K. T., Szurmann, P., Faul, D., May-Endres, K., Press, U., Luttke, J., Ziemssen, F., Bartz-Schmidt, U., Cordes, J., Raber, F., Mikielewicz, M., Kammerer, J., Kupferschmid, S., Buchwald, H., Werner, J., Kampmeier, J., Bula, A., Krauss, P., Strzalkowski, P., and Hillenkamp, J.

Abstract

Background On festive days worldwide eyes are severely injured by fireworks. The data on the number and severity are to date not registered in Germany. Objective How frequent are firework-induced injuries in Germany, who are the affected, how serious are the injuries, which forms of treatment are necessary and how frequent are accompanying injuries? Method A German nationwide online-based survey was carried out in all inpatient eye departments and data over the last 3 consecutive years were descriptively analyzed. Results From New Years Eve 2016/2017, when 41 eye departments sent in data, the participation could be increased to 51 eye departments in 2018/2019. More than one third (33-39%) of all 1356 patients over 3 years were minors, 60% were younger than 25 years old and roughly 60% of patients were injured as bystanders or in an unclear situation. In total 25% of all eye injuries were considered severe and required inpatient treatment. Accompanying injuries of the other eye, the face and hands were more frequent in minors than in adults. Eyeball ruptures were reported in 10 minors and 38 adults over the 3 years. Conclusion Particularly minors and bystanders need better protection.

Published
2019

6. Pandemiebedingtes Verkaufsverbot von Feuerwerkskörpern in Deutschland führt zu einer deutlichen Abnahme der Augenverletzungen

Author

Gabel-Pfisterer, Ameli, Böhringer, Daniel, Agostini, Hansjürgen, Feuerwerks-Verletzungen-Studiengruppe, Botros, Y., Krieb, A., Emmerich, K.-H., Grajewski, L., Krause, L., Hoa, D. Q., Yilmaz, S., Jabur, A., Rüdiger, K., Boeker, T., Rashitova, D., Eberlein, G., Lehmann, F., Sachs, H., Matthee, E., Pillunat, L., Juergens, L., Kaya, S., Guthoff, R., Steindorf, F., Korbmacher, J., Geerling, G., Märtz, J., Widder, R., Rössler, G., Iseed, A., Doulgkeridis, J., Erhard, J., Tomalla, M., von Jagow, B., Filev, F., Schill, S., Kotiasvili, T., Kojetinski, C., Flach, A., Zollfrank, C., Lieder, A., Blum, M., Tourtas, T., Knorr, H., Kruse, F., Freimuth, M., Dalbah, S., Sokolenko, E., Mueller, A., Rating, P., Kiefer, T., Book, B., Westerkemper, H., Böhm, M., Bornfeld, N., Bechrakis, N., Schultheiss, M., Scheider, A., Pawlowczicz, K., Hagenbusch, J., Müller, M., Kohnen, T., Ahdab, K., Eckert, T., Eckardt, C., Wisniewska, M., Just, A., Laich, Y., Stifter, J., Avar, M., Gritzka, M., Jehle, V., Reinhard, T., Rab, S., Seewald, J., Mais, C., Basiakos, S., Osman, B., Xanthopoulou, E., Friedburg, B., Graef, M. H., Dempe, C., Lorenz, B., Just, U., Schrecker, J., Klemming, J., Drüke, D., Bemmer, L., Weiß, S., Take, P., Nguyen-Höhl, A., Oterendorp, C., Al-Ashi, N., Feltgen, N., Hoerauf, H., Prusiecki, I., Elle, J., Gundel, B., Bender, M. C., Menges, A., Tost, F., Stahl, A., Wienrich, R., Breuß, H., Huth, A., Viestenz, A., Ueberschaar, J., Daehn, T., Brooks, U., Schindler, P., Bigdon, E., Bertram, P., Skevas, C., Kromer, R., Kuchenbecker, J., Casagrande, M., Grohmann, C., Mehlan, J., Spitzer, M., Schargus, M., Eddy, M., Schumacher, S., Keserü, M., Scheler, A., Foerster, M. H., Stemplewitz, B., Schaudig, U., Herden, J., Haar, M., Tode, B., Junker, B., Abou Mouli, W., Volkmann, I., Framme, C., Scheuerle, A., Seibel, I., Auerbach, M., Beisse, C., Rohrschneider, K., Auffahrt, G., Mala, N., Rosenthal, A., Hesse, L., Daas, L., Flockerzie, E., Suffo, S., Böker, A., Seitz, B., Chrisoglou, N., Wietstock, G., Augsten, R., Meller, D., Althauspetervari, I., Rudolph, O., Floeter, C., Beutner, A., Effert, R., Greve, D., Mayer, M., Vanselow, K., Lieb, W., Kandzia, C., Purtskhvanidze, K., Ehlken, C., Roider, J., Hueber, A., Cursiefen, K., Edelmann, C., Lenglinger, M., Schrage, N., Kroeger, M., Viehweg, N., Meier, P., Unterlauft, J. D., Wiedemann, P., Rehak, M., Ziemssen, F., Rommel, F., Sonntag, S., Müller, B., Prasuhn, M., Pawlik, V., Kakkassery, V., Ranjbar, M., Mohi, A., Grisanti, S., Bastron, I., Dindin-Sarac, S., Kaskel-Paul, S., Rawohl, J., Schönfeld, S., Hattenbach, L., Stoffelns, B., Schuster, A., Pfeiffer, N., Besgen, V., Schröder, F., Schulze, S., Weber, N., Sekundo, W., Schuart, C., Renieri, G., Weigel, M., Thieme, H., Hagenau, F., Wolf, A., Vounotrypidis, E., Priglinger, S., Penkava, J., Klein, J., Bechstein, L., Joussen, A., Maier, M., Lohmann, C., Haritoglu, C., Alten, F., Eter, N., Brinkmann, C., Alshikh, F., Klishko, V., Holland, U., Medra, A., Kolarov, D., Weber, A., Höh, H., Pielen, A., Zschockelt, T., Luciani, F., Schmidbauer, J., Horn, P., Kodomskoi, L., Kuempel, H., Schwarz, P., Rivera Gomez, C., Plantzas, K., Weiss, M., Hille, K., Esper, G., Mazko, K., Kolbeck, L., Malek, S., Kupper, P., Grafmueller, S., Puk, C., Schrader, S., Darawsha, R., Bellios, N., Wulff, V., Ghaffary, A., Ghoreishi, A., Höhn, F., Napholz, A., Tandogan, T., Schmidt, L., Berthold, A., Ilski, P., Trossowski, C., Zühlsdorff-Utke, M., Liekfeld, A., Winter, I., Böhm, A., Blecha, C., Barth, T., Helbig, H., Rusch, W., Wirbelauer, C., Noerenberg, A., Juenemann, A., Fuchsluger, T. A., Matar, C., Zuche, M., Roehrig, S., Decker, A., Kühn, M., Ladewig, M., Schmidt-Wetter, J., Hofmayer, H., Machulla, R., Boateng, A.-F., Dias Blak, M., Krawczyk, S., Lenhard, K., Lackner, B., Gekeler, F., Mamacek, D., Wocker, L., Holzschuh, I., Wachtlin, J., Boden, K. T., Szurmann, P., Faul, D., May-Endres, K., Press, U., Luttke, J., Wolfram, L., Reichel, F., Seitz, I., Bartz-Schmidt, U., Speidel, A., Cordes, J., Raber, F., Mikielewicz, M., Kammerer, J., Kupferschmid, S., Buchwald, H., Werner, J., Meyer, J. F., Kampmeier, J., Dithmar, S., Fischer, G., Pruefke, C., Bula, A., Krauß, P., Strzalkowski, P., Hillenkamp, J., Macher, T., Kuerten, D., Palka, K., Niemeyer, M., Walla, T., Pham, D., Aisenbrey, S., Rieck, P., Verbeck, J., Tatsiou, A., Walch, A., Burk, R., Fuest, M., Schnober, G., Elling, M., Schultz, T., Tsiampalis, N., Rehmann, J., Sliwowska, U., Schojai, M., Schulze, K., Kamguia, N., Wirtz, C., Walter, P., Dick, B., Bourauel, L., Schützeichel, F. M., Völcker, D., Wintergerst, M., Pfau, M., Melzer, C., Hoegen, D., Bosch, F., Andresen, J. C., Wanjek-Meyer, K., Krohne, T., Holz, F. G., Fries, U., Koch, M., Kwasnicki, A., Kathke, M., Noske, W., Sturm, A., Chankiewitz, E., Monastoriotis, S., Kohen, L., Kemper, O., Hübner, T., Feldmann, M., Morsek, J., Rainer, O., Bartsch, H., Ewald, K., Brandter, S., Cil, M. U., Hartmann, K., Siegmund, T., Bohlen, A., Mohr, A., Wienigk, A., Hecker, J., Smetana, P., Furashova, O., Engelmann, K., Shtaya, M., and Müller, A.-K.

Abstract

Die Ophthalmologie 119(12), 1257-1266 (2022). doi:10.1007/s00347-022-01778-1, Published by Springer Medizin, Berlin ; Heidelberg

Published
2022
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7. [Recanalisation by Probing with a Bicanalicular Silicone Tube (Oggel Silicone Intubation) in Patients with Acquired Lacrimal Stenosis].

Author

Baier MA, Mikielewicz M, Lang GK, and Kampmeier J

Subjects
Constriction, Pathologic, Humans, Intubation, Intubation, Intratracheal, Retrospective Studies, Silicones, Treatment Outcome, Dacryocystorhinostomy, Lacrimal Apparatus, Lacrimal Duct Obstruction diagnosis, Lacrimal Duct Obstruction therapy, Nasolacrimal Duct surgery
Abstract

Objectives: Recanalisation and bicanalicular splinting with silicone tube is one therapeutic option for acquired lacrimal duct stenosis, and restenosis is frequently achieved. The aim was to determine the therapeutic success of Oggel silicone intubation after lacrimal syringing and probing. We also analysed other characteristics of the complaint and compared the therapeutic success with published results., Methods: Therapeutic success was defined as subjective absence of complaints. Other complaint features - directly after explantation of the Oggel tube, one month after explantation and one year after explantation - were retrospectively collected by a patient questionnaire, and a questionnaire for the attending ophthalmologist. These were completed with information from the patient's file. We included 82 procedures performed at the Dept. of Ophthalmology, University of Ulm, between 2006 and 2015. Statistical testing of the impact of risk factors on therapeutic success was performed, using logistic regression analysis and the Mann-Whitney U test. Subgroups were compared using Pearson-Chi-square and Fisher's exact tests and a Kaplan-Meier analysis was also performed., Results: Therapeutic success could be documented in 80.8% of patients after explantation of the Oggel tube, in 61.6% of patients after one month and in 42.5% of patients at one year (n = 82). There were no significant differences between the subgroups of stenosis localisation, or the patients' age or sex. There was also no significant influence of the patient's age, the preoperative duration of complaints or risk factors predisposing for lacrimal duct stenosis. For the observation period of one year, the Kaplan-Meier analysis gave a probability of complaint-freeness of 52.2% for the patient group, as well as a mean duration of the complaint-free period of 34.2 weeks., Conclusion: The results allow a prognostic assessment of the therapeutic success in the absence of significant differences in the subgroups. The therapeutic success of bicanalicular silicone intubation with the Oggel tube was in the lower third of comparable studies. The results conform to the observation that there is a progressive decline of therapeutic success. The comparison of the literature turned out to be methodically more difficult due to differences in study characteristics. Standardisation would make sense for future studies., Competing Interests: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht., (Thieme. All rights reserved.)

Published
2020
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8. Experimental protocols for ex vivo lens stretching tests to investigate the biomechanics of the human accommodation apparatus.

Author

Pinilla Cortés L, Burd HJ, Montenegro GA, D'Antin JC, Mikielewicz M, Barraquer RI, and Michael R

Subjects
Adult, Aged, Aged, 80 and over, Aging physiology, Anterior Eye Segment physiopathology, Biomechanical Phenomena, Ciliary Body physiopathology, Humans, In Vitro Techniques methods, Middle Aged, Models, Biological, Presbyopia physiopathology, Stress, Mechanical, Accommodation, Ocular physiology, Lens, Crystalline physiopathology
Abstract

Purpose: To explore alternative experimental protocols to investigate the biomechanical behavior of the crystalline lens and zonules using ex vivo stretching., Methods: Radial stretching tests were conducted on the anterior segment (consisting of lens, zonules, ciliary body, and sclera) of four pairs of presbyopic human donor eyes. A simple mechanical model is used to describe the behavior of the anterior segment when tested in this way. Each pair of samples was initially stretched with the ciliary body intact. One sample was retested after cutting the ciliary body radially, and the other sample was retested after removing the lens., Results: The external forces needed to stretch the sample with the ciliary body intact were significantly greater than for the tests in which the ciliary body had been cut. The forces measured with the ciliary body intact and lens in situ were comparable to the sum of the forces measured in the tests in which the ciliary body had been cut (lens in situ) and the forces measured in the tests on the intact ciliary body with the lens removed., Conclusions: When stretching tests are conducted on the anterior segment, significant circumferential tensions develop in the ciliary body. This means that the forces applied to the lens and zonules cannot be related directly to the forces applied by the external loading system. If radial cuts are introduced in the ciliary body prior to testing, however, then this difficulty does not arise.

Published
2015
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9. Elastic properties of human lens zonules as a function of age in presbyopes.

Author

Michael R, Mikielewicz M, Gordillo C, Montenegro GA, Pinilla Cortés L, and Barraquer RI

Subjects
Aged, Aged, 80 and over, Elasticity, Female, Humans, Male, Middle Aged, Stress, Mechanical, Aging physiology, Lens Capsule, Crystalline physiology, Presbyopia physiopathology
Abstract

Purpose: To investigate the elastic properties of human lens zonules as a function of age in presbyopes., Methods: We studied 16 presbyopic human donor eyes (ages 47-97). Anterior eye sections with crystalline lens, zonules, ciliary body, and sclera were stretched radially. The stretching device consisted of a chamber filled with balanced salt solution and eight radial hooks to hold the anterior eye section. Radial stretching was created with a stepper motor connected to a digital outside micrometer for linear displacement and digital balance for force measurement. Three eye globes were used to test our methodology. For 13 eye globes, the spring constant, elastic modulus of the zonular system, and Young's modulus of the zonules were calculated., Results: We found linear dependence for force-elongation and force-strain relationships at all ages. In young presbyopic eyes (ages 47-60), the Young's modulus of the zonules was 340 mN/mm(2), whereas in older eyes (ages 83-97) it was significantly lower at 270 mN/mm(2). However, the correlation coefficient between Young's modulus and age (47-97 years) was not significant with P = 0.063., Conclusions: The zonular system in presbyopic eyes was linear elastic, and the Young's modulus of the zonules decreased 20% from presbyopic age to late presbyopic age. However, there was no significant correlation between Young's modulus and age in presbyopes.

Published
2012
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