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This article is based on the empirical data gained from a previous study “Ethnic-confessional relations in the Republic of Sakha (Yakutia) in 2011- 2013”. In the mid-nineties in the 20th century, the number of nationalities that were nontypical for the Far East, Siberia and the Far North of Russia began to enlarge, and the trend continues year by year. According to the analysis results, people who migrate are attracted to the republic. The capital of the republic, the industrial cities of Yakutsk, Mirny, and Aldan, as well as the settlements of Niznij Bestyakh of the Megino-Kangalasskij district and Kysyl-Syr of the Viluiskij district, are the center of the migration stream. To define the ethnic and confessional complementariness of the local population, a test-scale by Yu.I Zhegusov was used. The authors of the study refused a simple dichotomous division of ‘insiders’ and ‘outsiders’, and suggested a more complicated structure. In ethnic-confessional complementariness, the following levels and degrees were used: positive complementariness is expressed as ‘insiders’ who may be closely related( friendly terms, blood relationship) neutral complementariness is expressed as ‘outsiders’ with whom one may co-exist, but avoids close relations negative complementariness is expressed as ‘outsiders’ who are undesirable to live in a neighborhood with critical level of complementariness is expressed as ‘enemies’ who constitute a danger and threat. On the whole, the research shows some peculiarities: Russians are mostly comfortable with representatives of other ethnic groups and religions. In Yakutia, they feel confident in the context of ethnic and migration process intensification. Yakuts show an alarmist public mood and worry about their future, and they are afraid of losing their ethnic status and national identity as a result of the uncontrollable process of migration and assimilation.

Introduction: The main finding of a large-scale collaborative study (Rees et al. Nat Neurosci 2020;23(2) 179-184), which focused on  de novo  mutations in schizophrenia, was the discovery of an enrichment of these mutations in the  SLC6A1  gene. This gene encodes the gamma-aminobutyric acid (GABA) transporter GAT1, thereby encouraging further research into novel schizophrenia targets within the GABA pathway. However, the gene was not highlighted in recent schizophrenia genetic studies, while typically pathogenic  SLC6A1  mutations result in epilepsy, motor dysfunction, autistic spectrum disorder (ASD) and developmental delay. The absence of genetic replication for  SLC6A1 's involvement in schizophrenia and the differing clinical spectrum for  SLC6A1  mutations led us to study in depth one of the only three original probands from the Rees et al. 2020 study. Objectives: In our comprehensive case study, we delved deep into the relationship between the SLC6A1 mutation and schizophrenia. Methods: Our subject, a patient who first presented with acute mania symptoms at age 15 and was later diagnosed with schizophrenia, carried the SLC6A1 Arg211Cys mutation. Over a detailed 25-year follow-up, we conducted an array of assessments and tests, including cognitive testing, personality assessments, EEG, and 1H-MRS. Results: Notably, we discovered abnormal GABA levels, potentially indicating a dysfunction in GABA reuptake, adding a new layer of complexity to our understanding. Further analysis revealed a significant correlation between the patient's clinical picture and a polygenic background, rather than the SLC6A1 mutation. Despite having a high polygenic risk score for bipolar disorder, the dominant features of his condition were more representative of schizophrenia. Interestingly, neither the patient nor his father, who also showed a higher BP PRS, had a diagnosis of bipolar disorder. The pathogenic significance of the mutation warrants investigation in cells of neuronal origin. We generated induced pluripotent stem cells (iPSC) from the patient and his parents. This approach provides us with a platform for future investigations into the pathogenic significance of the mutation in neuronal cells. The Human Pluripotent Stem Cell Registry accession numbers of those cells are MHRCCGi001-A (patient), MHRCCGi005-A (mother) and MHRCCGi004-A (father). Conclusions: In the presented case the clinical picture is rather explained by the polygenic background than by the SLC6A1 Arg211Cys mutation. The study is supported by Russian Science Foundation, grant 21-15-00124 (https://rscf.ru/project/21-15-00124) Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]