55 results on '"Mike Stark"'
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2. Chasing the Ghost Bear: On the Trail of America's Lost Super Beast
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Mike Stark
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- 2022
3. Chasing the Ghost Bear
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MIKE STARK
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- 2022
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4. Mayo controlled substance advisory group: A multidisciplinary approach to managing patients on chronic controlled substances
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Benjamin Lai, Julie Cunningham, Sarah Crane, halena gazelka, Gabrielle Melin, Kim Bremseth, Jordan Haag, Wesley Gilliam, Lucinda Hanson, and Mike Stark
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- 2022
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5. An object-oriented approach to parameterized software in Ada.
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Ed Seidewitz and Mike Stark
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- 1991
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6. Receitas: Dump Dinner! Pratos rápidos e fáceis para pessoas ocupadas
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Mike Stark and Mike Stark
- Abstract
Dump Dinner! Pratos rápidos e fáceis para pessoas ocupadas Pouco tempo? Procurando por receitas que sejam rápidas e eficientes para fazer enquanto mantem o orçamento? Bem, você veio ao lugar certo! Você sempre quis receitas fáceis que podem ser feitas em poucos minutos? Bem, você está no lugar certo. Dump Dinners são uma forma popular de cozinhar onde você pega ingredientes e coloca-os em uma forma ou uma Slow Cooker e, em seguida, cozinha por um período de tempo. Eles são populares por causa da baixa manutenção que eles têm e eles não demoram muito para se preparar. Para aqueles que estão sempre em movimento, os Dump Dinners são uma ótima maneira de permitir que sua família tenha a comida que eles desejam sem muita dificuldade. Este livro lhe dará receitas fáceis de Dump Dinner que funcionam bem e você só precisa colocá-las na panela. Você não precisa ser um cozinheiro profissional para fazer essas receitas e você pode fazer essas receitas sem nenhum problemas. Você também pode pegar tudo preparado, assim você pode simplesmente colocá-los no na forma ou na Slow Cooker e então poderá ter um jantar perfeito para você. Faça isso e você terá tudo o que quiser sem nenhum atraso. Então o que você está esperando? Estas deliciosas refeições que são realmente gostosas de comer enquanto, ao mesmo tempo, economiza tempo e dinheiro durante a preparação estão a poucos minutos de distância. Dentro deste livro de receitas você encontrará 25 refeições saudáveis que irão satisfazer a sua família noite após noite. Esse livro de receita responderá a pergunta que você fez no dia do casamento:'O que vamos fazer com todas estas Slow Cookers?'. Este livro não só responderá a essa pergunta, mas irá fornecer refeições saudáveis e manter seu orçamento familiar no caminho certo!
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- 2018
7. Towards a general object-oriented Ada lifecycle.
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Mike Stark and Ed Seidewitz
- Published
- 1987
8. Discovery of a Soft Spectral Component and Transient 22.7 Second Quasi‐periodic Oscillations of SAX J2103.5+4545
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Altan Baykal, J. H. Swank, Mike Stark, and Sıtkı Çağdaş İnam
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Physics ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics (astro-ph) ,FOS: Physical sciences ,Flux ,Spectral density ,Astronomy and Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,Radius ,Neutron star ,Amplitude ,Space and Planetary Science ,Black-body radiation ,Astrophysics::Earth and Planetary Astrophysics ,Emission spectrum ,Spectroscopy ,Astrophysics::Galaxy Astrophysics - Abstract
XMM-Newton observed SAX J2103.5+4545 on January 6, 2003, while RXTE was monitoring the source. Using RXTE-PCA dataset between December 3, 2002 and January 29, 2003, the spin period and average spin-up rate during the XMM-Newton observations were found to be $354.7940\pm0.0008$ s and $(7.4\pm0.9)\times10^{-13}$Hz s$^{-1}$ respectively. In the power spectrum of the 0.9-11 keV EPIC-PN lightcurve, we found quasi periodic oscillations around 0.044 Hz (22.7 s) with an rms fractional amplitude $\sim $6.6 %. We interpreted this QPO feature as the Keplerian motion of inhomogenuities through the inner disk. In the X-ray spectrum, in addition to the power law component with high energy cutoff and $\sim6.4$ keV fluorescent iron emission line (Baykal et al., 2002), we discovered a soft component consistent with a blackbody emission with ${\rm{kT}}\sim1.9$keV. The pulse phase spectroscopy of the source revealed that the blackbody flux peaked at the peak of the pulse with an emission radius $\sim 0.3$ km, suggesting the polar cap on the neutron star surface as the source of blackbody emission. The flux of the iron emission line at $\sim 6.42$ keV was shown to peak at the off-pulse phase, supporting the idea that this feature arises from fluorescent emission of the circumstellar material around the neutron star rather than the hot region in the vicinity of the neutron star polar cap., Comment: 16 pages 4 figures. Major revisions present. Accepted for publication in ApJ
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- 2004
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9. Doppler Modulation of X-Ray Lines in Cygnus X-3
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Mike Stark and Malinda Saia
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Physics ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics (astro-ph) ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,Compact star ,Ephemeris ,Spectral line ,Stars ,symbols.namesake ,Space and Planetary Science ,Observatory ,Magnitude (astronomy) ,symbols ,Astrophysics::Solar and Stellar Astrophysics ,Astrophysics::Earth and Planetary Astrophysics ,Doppler effect ,Astrophysics::Galaxy Astrophysics ,Line (formation) - Abstract
We measured Doppler shifts of three bright spectral lines in the X-ray emission from Cygnus X-3 as recorded by the Chandra X-Ray Observatory. Doppler shifts of lines associated with Si XIV and S XVI exhibit orbital modulation. The magnitude and phasing of this modulation relative to the orbital ephemeris indicate the location of the source of this emission within the wind emanating from the compact object's companion. These observations enable us to make an indirect measurement of the separation of the two stars. Under certain assumptions our observation of a line associated with Fe XXV also limits the mass of the compact object M < 3.6 MSun., 7 pages, 3 figures, Accepted for publication in The Astrophysical Journal Letters
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- 2003
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10. X‐Ray Spectra and Pulse Frequency Changes in SAX J2103.5+4545
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Altan Baykal, Mike Stark, and Jean H. Swank
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Physics ,Spectral index ,Accretion (meteorology) ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics (astro-ph) ,FOS: Physical sciences ,Flux ,Astronomy and Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,Luminosity ,Pulsar ,Space and Planetary Science ,Astrophysics::Solar and Stellar Astrophysics ,K-alpha ,Astrophysics::Earth and Planetary Astrophysics ,Emission spectrum ,Equivalent width ,Astrophysics::Galaxy Astrophysics - Abstract
The November 1999 outburst of the transient pulsar SAX J2103.5+4545 was monitored with the large area detectors of the Rossi X-Ray Timing Explorer until the pulsar faded after a year. The 358 s pulsar was spun up for 150 days, at which point the flux dropped quickly by a factor of 7, the frequency saturated and, as the flux continued to decline, a weak spin-down began. The pulses remained strong during the decay and the spin-up/flux correlation can be fit to the Ghosh and Lamb derivations for the spin-up caused by accretion from a thin, pressure-dominated disk, for a distance 3.2 kpc and a surface magnetic field 1.2 10^{13} Gauss. During the bright spin-up part of the outburst, the flux was subject to strong orbital modulation, peaking 3 days after periastron of the eccentric 12.68 day orbit, while during the faint part, there was little orbital modulation. The X-ray spectra were typical of accreting pulsars, describable by a cut-off power-law, with an emission line near the 6.4 keV of K alpha fluorescence from cool iron. The equivalent width of this emission did not share the orbital modulation, but nearly doubled during the faint phase, despite little change in the column density. The outburst could have been caused by an episode of increased wind from a Be star, such that a small accretion disk is formed during each periastron passage. A change in the wind and disk structure apparently occurred after 5 months such that the accretion rate was no longer modulated or the diffusion time was longer. The distance estimate implies the X-ray luminosity observed was between 1 10^{36} ergs s^{-1} and 6 \times 10^{34} ergs s^{-1}, with a small but definite correlation of the intrinsic power-law spectral index., Accepted for publication in Astrophysical Journal
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- 2002
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11. Differences between the two anomalous X-ray pulsars: variations in the spin-down rate of 1E 1048.1−5937 and an extended interval of quiet spin-down in 1E 2259+586
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Mike Stark, Jean H. Swank, Altan Baykal, M. Ali Alpar, and Tod E. Strohmayer
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Physics ,Accretion (meteorology) ,Pulsar ,Space and Planetary Science ,Astrophysics::High Energy Astrophysical Phenomena ,QUIET ,Phase (waves) ,Flux ,Astronomy and Astrophysics ,Astrophysics ,Noise (radio) ,Spin-½ ,Luminosity - Abstract
We analysed the RXTE archival data of 1E 1048.1-5937 covering a time span of more than one year. The spin down rate of this source decreases by 30 percent during the observation. We could not resolve the X-ray flux variations because of contamination by Eta Carinae. We find that the level of pulse frequency fluctuations of 1E 1048.1-5937 is consistent with typical noise levels of accretion powered pulsars. Recent RXTE observations of 1E 2259+586 have shown a constant spin down with a very low upper limit on timing noise. We used the RXTE archival X-ray observations of 1E 2259+586 to show that the intrinsic X-ray luminosity times series is also stable, with an rms fractional variation of less than 15 percent. The source could have been in a quiet phase of accretion with a constant X-ray luminosity and spin down rate.
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- 2002
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12. The impact of Ada and object-oriented design in NASA Goddard's Flight Dynamics Division
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Sharon Waligora, John Bailey, and Mike Stark
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Object-oriented programming ,business.industry ,Computer science ,Fortran ,Programming language ,Computer programming ,Software development ,computer.software_genre ,Software quality ,Object-oriented design ,Ada ,Software ,General Earth and Planetary Sciences ,business ,Software engineering ,computer ,General Environmental Science ,computer.programming_language - Abstract
This paper presents the highlights and key findings of 10 years of use and study of Ada and object-oriented design in NASA Goddard's Flight Dynamics Division (FDD). In 1985, the Software Engineering Laboratory (SEL) began investigating how the Ada language might apply to FDD software development projects. Although they began cautiously using Ada on only a few pilot projects, they expected that, if the Ada pilots showed promising results, the FDD would fully transition its entire development organization from FORTRAN to Ada within 10 years. However, 10 years later, the FDD still produced 80 percent of its software in FORTRAN and had begun using C and C++, despite positive results on Ada projects. This paper presents the final results of a SEL study to quantify the impact of Ada in the FDD, to determine why Ada has not flourished, and to recommend future directions regarding Ada. Project trends in both languages are examined as are external factors and cultural issues that affected the infusion of this technology. The detailed results of this study were published in a formal study report [1] in March of 1995. This paper supersedes the preliminary results of this study that were presented at the Eighteenth Annual Software Engineering Workshop in 1993 [2].
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- 1997
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13. Pulse Arrival Time Glitches in GRO J1744−28
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Tod E. Strohmayer, Mike Stark, Altan Baykal, and Jean H. Swank
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Physics ,Accretion (meteorology) ,Astrophysics::High Energy Astrophysical Phenomena ,Phase (waves) ,Astronomy ,Astronomy and Astrophysics ,Astrophysics ,Light curve ,Glitch ,Pulse (physics) ,Superfluidity ,Neutron star ,Pulsar ,Space and Planetary Science - Abstract
We observe glitches in the arrival times of X-ray pulses from GRO J1744-28 associated with the large X-ray bursts observed from this source. In early observations, the pulse arrival time becomes delayed by 28 ms (6% of the 467 ms pulsar period) following bursts while the shape of the nearly sinusoidal light curve is essentially unchanged. This arrival-time lag decays exponentially over the next ~1000 s. In later observations, the observed phase lags are smaller, and eventually, some bursts appear to be accompanied by a small phase advance. While explanations of these observations that rely upon changes in the postburst accretion flow are natural, our observations present some problems for these explanations. It may be that this behavior can be understood by analogy with glitches in spinning-down radio pulsars, though this explanation has its own problems. Explained as a glitch, the phase shift is the result of coupling of the neutron star's crust to the crustal superfluid, which is spun up more slowly than the rest of the star, and the recovery is due to coupling between the crust and the core of the neutron star.
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- 1996
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14. The Main Characteristics of GRO J1744−28 Observed by the Proportional Counter Array Experiment on the [ITAL]Rossi X-Ray Timing Explorer[/ITAL]
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W. W. Zhang, Jean H. Swank, A. B. Giles, Edward H. Morgan, Keith Jahoda, Mike Stark, and Tod E. Strohmayer
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Physics ,Oscillation ,Astronomy ,Proportional counter ,Flux ,Astronomy and Astrophysics ,Astrophysics ,Intensity (physics) ,Luminosity ,symbols.namesake ,Amplitude ,Pulsar ,Space and Planetary Science ,Eddington luminosity ,symbols - Abstract
In this Letter, we provide an introduction to the main features seen in a series of observations of the bursting pulsar GRO J1744-28. The observations were made from 1996 January through May with the proportional counter array on the Rossi X-Ray Timing Explorer spacecraft. In the 2-10 keV band, GRO J1744-28 emitted large bursts of ~10 s duration at a rate of about 2 per hour. The peak flux during these bursts was ~6-40 times greater than that in the quiescent, or nonbursting, periods. For the earliest bursts, the inferred peak luminosity approaches 100 times the Eddington limit, which is suggestive of some kind of beaming mechanism. A range of smaller bursts and quasi-periodic oscillation features were also seen. All this activity was superposed on an almost perfect sinusoidal modulation at a frequency of 2.14 Hz with an amplitude of ~10% of the nonbursting flux. The source's persistent flux declined in a roughly linear trend from late January until mid-May, by which time its intensity was confused with several other sources.
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- 1996
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15. Generalized support software
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Mike Stark and Ed Seidewitz
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Software ,General Computer Science ,Human–computer interaction ,Computer science ,business.industry ,Experience report ,Domain analysis ,business - Published
- 1994
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16. Impacts of object-oriented technologies: Seven years of software engineering
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Mike Stark
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Object-oriented programming ,Engineering ,Hardware and Architecture ,business.industry ,Premise ,Factory (object-oriented programming) ,Software engineering ,business ,Software ,Information Systems - Abstract
This article examines the premise that object-oriented technology (OOT) is the most significant technology ever examined by the Software Engineering Laboratory (SEL). The evolution of the use of OOT in the SEL “Experience Factory” is described in terms of the SEL's original expectations, focusing on how successive generations of projects have used OOT. General conclusions are drawn on how the usage of the technology has evolved in this environment.
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- 1993
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17. Object-oriented programming: The promise and the reality
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Mary Beth Rosson, Iris Vessey, Shyam R. Chidamber, Mike Stark, Al Goerner, Jean Scholtz, and Robert L. Glass
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Technology education ,Engineering ,Object-oriented programming ,business.industry ,Software development ,Reuse ,Engineering management ,Naturalness ,Hardware and Architecture ,Center (algebra and category theory) ,Artificial intelligence ,State (computer science) ,business ,Software ,Information Systems ,Design technology - Abstract
This article summarizes a workshop organized and conducted by the authors on April 1 and 2, 1993, under the auspices of Portland State University and the Oregon Center for Advanced Technology Education. This workshop provided a uniquely comprehensive and realistic look at the state of the art and practice of object-oriented programming. Issues discussed at the workshop and summarized here include the naturalness of object-oriented technology, reuse potential, programming support and evaluation tools, and the cost of converting to an object-oriented design technology. The findings should be of interest to researchers, organizations, and individuals who are exploring and/or using the object-oriented approach to software development. The article concludes by offering some recommendations for the use of objectoriented technology.
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- 1993
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18. New limit on the rate-density of evaporating black holes
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D. D. Weeks, David A. Williams, G. M. Dion, C. Y. Chang, Mike Stark, M. L. Chen, C. Dion, A. L. Shoup, R. L. Burman, J. P. Wu, G. E. Allen, W. Zhang, J. A. Goodman, S. R. Klein, P. Chumney, C. M. Hoffman, T. J. Haines, S. D. Biller, D. E. Dorfan, M. Cavalli-Sforza, G. B. Yodh, D. M. Schmidt, D. G. Coyne, R. Schnee, C. Sinnis, D. E. Nagle, D. Berley, Luke Zoltan Kelley, T. Yang, M. Harmon, D. E. Alexandreas, and R. W. Ellsworth
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Black hole ,Physics ,Astrophysics::High Energy Astrophysical Phenomena ,Gamma ray ,Orders of magnitude (length) ,General Physics and Astronomy ,Astrophysics ,Emission spectrum ,Gamma-ray burst ,Energy source ,Upper and lower bounds ,Spectral line - Abstract
Data taken with the CYGNUS detector between 1989 September and 1993 January have been used to search for 1 s bursts of ultrahigh-energy gamma rays from point sources at arbitrary locations in the northern sky. We find no evidence for such bursts. We set a theory-dependent upper limit on the rate-density of evaporating black holes of 8.5\ifmmode\times\else\texttimes\fi{}${10}^{5}$ ${\mathrm{pc}}^{\mathrm{\ensuremath{-}}3}$ ${\mathrm{yr}}^{\mathrm{\ensuremath{-}}1}$ at the 99% C.L. When the same emission spectrum is used to recalculate previous upper limits based on direct searches, this limit is the most restrictive by nearly 2 orders of magnitude.
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- 1993
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19. Shenzi 16-Inch Oil Export SCR CVA Verification
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Paul Stanton, Ruxin Song, Weiyong Qiu, Rene Casadaban, and Mike Stark
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Environmental science - Abstract
Abstract In 2006 Enterprise developed a 16-inch oil export system from Shenzi field located in Green Canyon Block 653 in the Gulf of Mexico, approximately 120 nautical miles offshore in approximately 4,375 ft of water depth. The oil export system is attached to the Shenzi TLP host facility. The 16-inch oil export SCR system is subject to the CVA (Certified Verification Agent) verification required by MMS (Minerals Management Service) 30 CFR Part 250 [Ref. 1]. NTL No. 2007-G14 [Ref. 2] was issued pursuant to 30 CFR 250.103 to provide clarification and guidance for pipeline riser design, fabrication, and installation under the platform verification program specified in 30 CFR 250.909 through 918. This paper summarizes the 16-inch oil export SCR CVA verification procedure. This paper presents a systematic SCR CVA verification procedure. The CVA verification procedure includes SCR CVA verification preparation, and verification of SCR design, fabrication, and installation. The verification procedure and table formats developed are unique and applicable to other types of pipeline risers in the Gulf of Mexico. Introduction The Shenzi field is located in the deepwater central Gulf of Mexico approximately 120 miles from the Louisiana coast. The field comprises Green Canyon Blocks 609, 610, 653, and 654. Water depth at the site is approximately 4,300 ft. Figure 1 presents the Shenzi Field layout [Ref. 3]. The Shenzi Oil Export Pipeline and SCR will transport crude oil from BHP Billiton's Tension Leg Platform (TLP) in Green Canyon Block 653 in approximately 4500 fsw to the Ship Shoal 332B Platform in approximately 435 fsw. Figure 2 presents an artist's rendering of the Shenzi TLP [Ref. 3]. 30 CFR Part 250 was published in the Federal Register on July 19, 2005. The rule became effective on August 18, 2005. 30 CFR 250.909 through 250.918 applies to new pipeline risers attached to the floating platforms in the Gulf of Mexico. The rule defines the CVA nomination, CVA's primary responsibilities, CVA's primary duties during the design phase, CVA's primary duties during the fabrication phase, and the CVA's primary duties during the installation phase. The detailed engineering design of Shenzi 16-inch oil export SCR started at the beginning of 2006. So it was one of the earliest SCRs subjected to the CVA program. This paper presents a systematic SCR CVA verification procedure developed during Shenzi 16-inch oil export SCR CVA verification project. The verification procedure includes SCR CVA verification preparation, SCR design CVA verification, SCR fabrication CVA verification, and SCR installation CVA verification. The verification procedure and table formats developed are unique and applicable to other types of pipeline risers in the Gulf of Mexico. SCR Design Data SCR Data The API 5L X-65 steel grade has been selected for the oil export SCR. Table 1 summarizes the oil export SCR data, pipe wall thickness tolerances, corrosion allowance, SCR coating data, and VIV suppression device data. Internal Fluid, Design Pressure and Temperature Design pressure and temperature are 3,540 psig and 140 ?F. For normal operating condition, the pressure and temperature are 3,220 psig and 120 ?F. For hurricane shut-down condition, the pressure and temperature are 3,540 psig and 120 ?F. The oil density is 54.0 pcf and the pressure reference elevation is 200 ft above mean sea level for all conditions.
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- 2009
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20. Feasibility of Using Stress Joint in an Existing Flexible Joint Receptacle for a Deepwater SCR
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Mike Stark, Paul Barnett, Basim B. Mekha, and Alok Kumar
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Engineering ,Flexibility (anatomy) ,business.industry ,Structural engineering ,Welding ,Finite element method ,law.invention ,Stress (mechanics) ,medicine.anatomical_structure ,law ,Hull ,Catenary ,medicine ,Bending moment ,business ,Joint (geology) - Abstract
In recent years, most fluid produced or exported has been transported using steel catenary risers (SCRs) attached to deepwater floating structures. The SCRs are terminated at the floating structures using Top Termination Units (TTUs) such as flexible joints or tapered stress joints. The flexible joints are usually designed to allow the riser to rotate with the floating structure motion and reduce the amount of moments transferred to the hull structure. The flexible joints depend on the flexibility and compressibility of the elastomer layers to allow for the rotation of the SCR. The stress joints, alternatively, provide fixed support at the hull and thus larger bending moment that has to be accounted for in the hull design. The stress joints can be made of steel or titanium material. The SCR TTU’s receptacle, which will be welded to the hull porch and contains the TTU basket, has to be designed to meet the force and reaction requirements associated with the selected TTU type. However, in some cases which could be due to failure of the TTU to meet the expected life or the operational requirements, the operators may have to replace the damaged TTU with another one or with a different TTU type. A few examples are available in the Gulf of Mexico. Recently the Flexible Joint TTU of the Independent Hub 20-inch export SCR had an operational problem. During the course of investigating the related issues and studying possible solutions, one option considered was the feasibility of replacing the Flexible Joint (FJ) with Titanium Tapered Stress Joint (TSJ). This paper highlights the issues that have to be considered in the design of the FJ existing receptacle to accommodate the force reactions of a Titanium TSJ. These issues are addressed and the results of the detailed finite element analysis performed are provided. The analysis conclusions, which are related to the feasibility of the existing receptacle to receive the loads imposed by TSJ and the modifications required to achieve this, are presented.Copyright © 2009 by ASME
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- 2009
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21. DW RUPE: A New Deepwater Pipeline Repair Capability for the Gulf of Mexico and Other Deepwater Regions
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Armando Rebello, Mike Stark, Ray R. Ayers, Eric Gage, and Steve Hoysan
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Environmental science ,Pipeline (software) ,Marine engineering - Abstract
Abstract Described herein is a chronology for developing a deepwater pipeline repair system and cooperative ownership group for affecting emergency repairs of damaged pipelines. Using a Joint Industry Project (JIP) funding model, technology development started in 2004, and continued as Hurricanes Katrina and Rita hit in 2005, and resulted in the formation of DW RUPE - Pipelines Co-Ownership Group in May of 2007. Included in this paper is a description of the repair methods developed, and repair tools being procured and developed for affecting 10 to 24 inch ANSI pipeline repairs in 1,000 to 10,000 feet of water. A recently-developed spreadsheet-based pipe lifting analysis laptop computing tool is described for use in planning pipe lifting and cutting operations for a specific emergency pipeline repair operation in deep water. Background on the Formation of DW RUPE In 2004 Phase 1 of a JIP was formed to develop a low CAPEX emergency repair capability for pipelines and flowlines in water depths in the 1,000-10,000 ft range, in the US Gulf of Mexico. Stress Subsea, Inc. (SSI) performed a Failure Mode and Effects Analysis, conducted interviews with suppliers and operators and included input from the JIP Steering Committee. Phase 1 JIP Conclusions As a result from DW RUPE, Phase 1, the following conclusions were drawn for export pipelines:The probability of needing a deepwater repair is low, but the consequences resulting from pipeline damage are high. Because of this, the project agreed upon pursuing a low CAPEX repair solution, recognizing the need to minimize capital expenditures since the probabilities of occurrence are low.The most likely damage types are wet and dry buckles caused by anchor snags (the DW RUPE shallower water depth range is 1,000 ft., hence anchoring damage is still a consideration).Potential repair solutions for a low CAPEX pipeline repair and a low CAPEX flowline repair are different.Traditionally a leak clamp and a spool piece connector set are needed for each pipe size. The project pursued a new paradigm of adapting and employing full structural clamps in place of connectors. This allows two clamps to be used in a spool piece repair or one of the structural clamps to be used alone for a pinhole leak from a cracked weld. Two clamps serve the same function as two connectors and a clamp (Pipeline Repair), thus reducing the CAPEX investment for inventory.Cracked welds are the most likely cause for pinhole leaks. Full structural clamps are advised to arrest crack propagation (Pipeline Repair).
- Published
- 2008
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22. Timing Studies on RXTE Observations of SAX J2103.5+4545
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Altan Baykal, Arif Emre Erkoca, C. M. Heffner, Mike Stark, Jean H. Swank, and Sıtkı Çağdaş İnam
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Orbital elements ,Physics ,media_common.quotation_subject ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics (astro-ph) ,Flux ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,Orbital period ,01 natural sciences ,Power law ,Spectral line ,Pulsar ,13. Climate action ,Space and Planetary Science ,0103 physical sciences ,Eccentricity (behavior) ,010306 general physics ,010303 astronomy & astrophysics ,Noise (radio) ,media_common - Abstract
SAX J2103.5+4545 has been continuously monitored for $\sim $ 900 days by Rossi X-ray Timing Explorer (RXTE) since its outburst in July 2002. Using these observations and previous archival RXTE observations of SAX J2103.5+4545, we refined the binary orbital parameters and find the new orbital period as P= (12.66536 $\pm $ 0.00088) days and the eccentricity as 0.4055$\pm$ 0.0032. With these new orbital parameters, we constructed the pulse frequency and pulse frequency derivative histories of the pulsar and confirmed the correlation between X-ray flux and pulse frequency derivative presented by Baykal, Stark and Swank (2002). We constructed the power spectra for the fluctuations of pulse frequency derivatives and found that the power law index of the noise spectra is 2.13 $\pm$ 0.6. The power law index is consistent with random walk in pulse frequency derivative and is the steepest among the HMXRBs. X-ray spectra analysis confirmed the inverse correlation trend between power-law index and X-ray flux found by Baykal, Stark and Swank (2002)., Comment: 23 pages, 7 figures, revised version accepted for publication in MNRAS
- Published
- 2006
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23. Calibration of the Rossi X-ray Timing Explorer Proportional Counter Array
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Yana L. Radeva, Keith Jahoda, William W. Zhang, Jean H. Swank, Arnold H. Rots, Mike Stark, Tod E. Strohmayer, and Craig B. Markwardt
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Physics ,Photon ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics (astro-ph) ,X-ray ,Astrophysics::Instrumentation and Methods for Astrophysics ,Proportional counter ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,Crab Nebula ,Pulsar ,Space and Planetary Science ,Calibration ,Energy (signal processing) - Abstract
We present the calibration and background model for the Proportional Counter Array (PCA) aboard the Rossi X-ray Timing Explorer (RXTE). The energy calibration is systematics limited below 10 keV with deviations from a power-law fit to the Crab nebula plus pulsar less than 1%. Unmodelled variations in the instrument background amount to less than 2% of the observed background below 10 keV and less than 1% between 10 and 20 keV. Individual photon arrival times are accurate to 4.4 micro-seconds at all times during the mission and to 2.5 micro-seconds after 29 April 1997. The peak pointing direction of the five collimators is known to a precision of a few arc-seconds, 77 pages, 34 figures. accepted by Ap J Supplement for April 2006 issue. This paper and additional calibration information are available from http://universe.gsfc.nasa.gov/xrays/programs/rxte/pca/ pcapage.html. Revised version contains minor changes to match accepted version
- Published
- 2005
24. Adopting and Institutionalizing a Product Line Culture
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David M. Weiss, Mike Stark, Charles W. Krueger, Günter Böckle, Julio Cesar Sampaio do Prado Leite, Jesús Bermejo Muñoz, Peter Knauber, Frank van der Linden, and Linda Northrop
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Engineering management ,Work (electrical) ,Operations research ,Computer science ,business.industry ,Product line ,Software development ,Domain engineering ,Plan (drawing) ,Business case ,Software product line ,business - Abstract
The strengths of product line engineering have been described before. But how can an organization make the move from developing one-of products to product line engineering without major interruptions in the day-today work? This paper describes how to perform the transition to product line engineering and lists the various strategies for such a transition. It also describes how to create an adoption plan and how to institutionalize product line engineering in an organization.
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- 2002
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25. Quantifying Product Line Benefits
- Author
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Peter Knauber, Günter Böckle, Mike Stark, Julio Cesar Sampaio do Prado Leite, Jesús Bermejo Muñoz, David M. Weiss, Linda Northrop, and Frank van der Linden
- Subjects
Engineering ,Software ,Quality management ,Risk analysis (engineering) ,business.industry ,Time to market ,Systems engineering ,Product (category theory) ,Reuse ,Business case ,business ,Software product line ,Product engineering - Abstract
Software product lines promise benefits like development and maintenance effort reduction, time to market decrease, and quality improvement, all resulting from planned and systematic reuse of common core assets. However, very little quantitative data has been measured so far to prove these promises. This paper formulates and discusses 7 hypotheses on howthe promised advantages would look like in a quantitative way. It is meant to be a starting point for discussion on how to quantify which product line benefits and how they can be measured.
- Published
- 2002
- Full Text
- View/download PDF
26. Discovery of the Orbit of the Transient X ray Pulsar SAX J2103.5+4545
- Author
-
Mike Stark, Altan Baykal, and Jean H. Swank
- Subjects
Physics ,Brightness ,media_common.quotation_subject ,Astrophysics (astro-ph) ,FOS: Physical sciences ,Astronomy and Astrophysics ,Orbital eccentricity ,Astrophysics ,Orbital period ,Light curve ,Orbit ,Pulsar ,Space and Planetary Science ,Sky ,media_common ,X-ray pulsar - Abstract
Using X-ray data from the Rossi X-Ray Timing Explorer (RXTE), we carried out pulse timing analysis of the transient X-ray pulsar SAX J2103.5+4545. An outburst was detected by All Sky Monitor (ASM) October 25 1999 and reached a peak X-ray brightness of 27 mCrab October 28. Between November 19 and December 27, the RXTE/PCA carried out pointed observations which provided us with pulse arrival times. These yield an eccentric orbit (e= 0.4 \pm 0.2) with an orbital period of 12.68 \pm 0.25 days and light travel time across the projected semimajor axis of 72 \pm 6 sec. The pulse period was measured to be 358.62171 \pm 0.00088 s and the spin-up rate (2.50 \pm 0.15) \times 10^{-13} Hz s^{-1}. The ASM data for the February to September 1997 outburst in which BeppoSAX discovered SAX J2103.5+4545 (Hulleman, in't Zand and Heise 1998) are modulated at time scales close to the orbital period. Folded light curves of the 1997 ASM data and the 1999 PCA data are similar and show that the intensity increases at periastron passages., To appear in The Astrophysical Journal (Letters)
- Published
- 2000
27. The Pulsar in GRO J1744-28 at Low Flux
- Author
-
A. M. Ahearn, L. J. Duva, Mike Stark, and Keith Jahoda
- Subjects
Physics ,Flux (metallurgy) ,Pulsar ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics (astro-ph) ,Astrophysics::Instrumentation and Methods for Astrophysics ,FOS: Physical sciences ,Astrophysics::Solar and Stellar Astrophysics ,Astrophysics ,Accretion (astrophysics) - Abstract
The Bursting Pulsar, GRO J1744-28, has been observed with the Rossi X-ray Timing Explorer (RXTE) regularly since the launch of the satellite in December 1995. This accretion driven pulsar has undergone two outbursts which have been accompanied by significant spin-up of the pulsar. Between these two outbursts, the pulsar was detectable during each observation down to fluxes perhaps one thousandth of the persistent flux at the peak of the first outburst. We observe evidence of a change in the sign of the frequency derivative during the faintest period but the relationship between the observed luminosity and the frequency derivative is complex., 4 pages, 2 figures, AIP Proceedings LaTex format, to appear in "Accretion Processes in Astrophysical Systems", Proc. of the 8th Annual Astrophysics Conference in Maryland, S. S. Holt & T. Kallman (eds.)
- Published
- 1997
28. Determination of peak fluxes and α for bursts from GRO J1744-28
- Author
-
Jean H. Swank, Mike Stark, Keith Jahoda, and Tod E. Strohmayer
- Subjects
Physics ,Peak response ,Bursting ,Neutron star ,Flux (metallurgy) ,Pulsar ,X-ray binary ,Astronomy ,Proportional counter ,Astrophysics ,Luminosity - Abstract
The Rossi X-ray Timing Explorer (RXTE) has been monitoring the Bursting Pulsar, GRO J1744-28, since Jan. 1996. Large deadtimes in the proportional counter array (PCA) have made measurements of the peak flux during bursts problematic, therefore the value α, of the ratio of time averaged persistent luminosity to time averaged burst luminosity, has not been well determined. The value of α has important implications for understanding the nature of the bursts. Some RXTE observations begun after the recent reemergence of GRO J1744-28 in Dec. 1996 were performed with the source offset from the axis of peak PCA response. This reduces the deadtime in the PCA and allows a more precise determination of burst peak fluxes and thus α. These observations provide an understanding of the deadtime processes during periods when the source was viewed at peak response. Between 17–24 January 1997 we estimate that α was ≈34. Based on similarity of the overall lightcurve and countrate, this value is also appropriate for the peri...
- Published
- 1997
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- View/download PDF
29. In-orbit performance and calibration of the Rossi X-ray Timing Explorer (RXTE) Proportional Counter Array (PCA)
- Author
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Keith Jahoda, Jean H. Swank, Edward H. Morgan, William W. Zhang, Tod E. Strohmayer, Mike Stark, and A. B. Giles
- Subjects
Physics ,Astrophysics::High Energy Astrophysical Phenomena ,media_common.quotation_subject ,Astronomy ,Proportional counter ,Astrophysics ,Scintillator ,Orbital mechanics ,Sky ,Orbit (dynamics) ,Calibration ,Satellite ,Circular orbit ,media_common - Abstract
The proportional counter array (PCA) is designed to perform microsecond timing of bright galactic sources and broad band, confusion limited, studies of faint extragalactic sources in the 2 - 60 keV x-ray band. The PCA was launched as part of the Rossi X-ray Timing Explorer (RXTE) satellite into a circular orbit of altitude 580 km and 23 degrees inclination on December 30, 1995. The mission contains three experiments: a set of large area xenon proportional counters sensitive from 2 - 60 keV (proportional counter array: PCA), a set of large area sodium iodide scintillators sensitive from 15 - 200 keV (high energy x-ray timing experiment: HEXTE), and three wide field of view scanning detectors which monitor most of the sky each orbit (all sky monitor: ASM). The goals of the mission are summarized by Swank et al. We present performance and calibration data on the measured and predicted in-orbit background, energy response, relative and absolute timing performance, and the operational possibilities made available with the high performance experiment data system (EDS) designed and built by MIT.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
- Published
- 1996
- Full Text
- View/download PDF
30. Yeast Gene Analysis
- Author
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Ian Stansfield, Mike Stark, Ian Stansfield, and Mike Stark
- Subjects
- Genetics--Technique, Yeast--Genetics, Microbiology--Technique
- Abstract
Focusing on Saccharomyces cerevisiae, the second edition of Yeast Gene Analysis represents a major reworking of the original edition, with many completely new chapters and major revisions to all previous chapters. Originally published shortly after completion of the yeast genome sequence, the new edition covers many of the major genome-wide strategies that have been developed since then such as microarray analysis of transcription, synthetic gene array studies, protein microarrays and chemical genetic approaches. It represents a valuable resource for any research laboratory using budding yeast as their experimental system in which to identify new yeast gene functions. The chapters are written in a readable style with useful background information, technical tips and specific experimental protocols included as appropriate, enabling both the novice and the experienced yeast researcher to adopt new procedures with confidence. - New chapters on: Strain construction; genome-wide two-hybrid approaches; use of microarrays for transcript analysis; real-time analysis of chromosome behaviour and FRET; synthetic gene array technology and protein arrays; chemical genomics and yeast prions; RNA gene analysis and mitochondrial gene function analysis; phylogenetic footprinting; discovering human gene function and predicting yeast gene function
- Published
- 2007
31. Evolving toward object-oriented technology in large organizations (panel)
- Author
-
Mohamed E. Fayad, Brad Balfour, Mike Stark, Bernard Rosenfeld, and Steven D. Litvintchouk
- Subjects
Knowledge management ,General Computer Science ,business.industry ,Computer science ,business ,Object oriented technology ,Software engineering ,Computer Graphics and Computer-Aided Design ,Software - Published
- 1993
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- View/download PDF
32. Impacts of object-oriented technologies
- Author
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Mike Stark
- Subjects
Programming in the large and programming in the small ,Object-oriented programming ,business.industry ,Computer science ,Programming language ,Computer programming ,Software development ,computer.software_genre ,Extensible programming ,Inductive programming ,Engineering management ,System programming ,Extreme programming practices ,Procedural programming ,High-level programming language ,Component-based software engineering ,Software construction ,Programming paradigm ,Factory (object-oriented programming) ,Fifth-generation programming language ,business ,computer ,Declarative programming ,Programming language theory - Abstract
This paper examines the premise that object-oriented technology (OOT) is the most significant technology ever examined by the Software Engineering Laboratory. The evolution of the use of OOT in the Software Engineering Laboratory (SEL) 'Experience Factory' is described in terms of the SEL's original expectations, focusing on how successive generations of projects have used OOT. General conclusions are drawn on how the usage of the technology has evolved in this environment.
- Published
- 1993
- Full Text
- View/download PDF
33. Observation of shadowing of ultrahigh-energy cosmic rays by the Moon and the Sun
- Author
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R. L. Talaga, J. Lloyd-Evans, D. E. Alexandreas, P. R. Vishwanath, M. K. Gilra, M. E. Potter, R. L. Burman, G. B. Yodh, C. M. Hoffman, D. A. Krakauer, P. W. Kwok, D. Berley, Mike Stark, S. Gupta, X. Q. Lu, C. Y. Chang, W. Zhang, R. C. Allen, G. M. Dion, D. R. Cady, V. D. Sandberg, R. W. Ellsworth, D. E. Nagle, Brenda Dingus, T. J. Haines, S. D. Biller, and J. A. Goodman
- Subjects
Physics ,Photon ,genetic structures ,integumentary system ,Degree (graph theory) ,Physics::Instrumentation and Detectors ,Astrophysics::High Energy Astrophysical Phenomena ,Astronomy ,Cosmic ray ,Astrophysics ,Particle detector ,Radiation flux ,Air shower ,High Energy Physics::Experiment ,Angular resolution ,Astrophysics::Earth and Planetary Astrophysics ,Energy (signal processing) - Abstract
Data from an extensive air shower detector of ultrahigh-energy cosmic rays shows shadowing of the cosmic-ray flux by the Moon and the Sun with significance of 4.9 standard deviations. This is the first observation of such shadowing. The effect has been used to determine that the angular resolution of the detector is 0.75{degree} {sub {minus}0.90{degree}}{sup +0.13{degree}}.
- Published
- 1991
34. The showerfront time-structure of ‘‘anomalous muon’’ events associated with Hercules X-1
- Author
-
Mike Stark, D. E. Nagle, J. A. Goodman, D. R. Cady, G. M. Dion, M. E. Potter, D. A. Krakauer, P. W. Kwok, C. M. Hoffman, J. Lloyd-Evans, C. Y. Chang, R. L. Burman, D. Berley, W. P. Zhang, G. B. Yodh, B. L. Dingus, D. E. Alexandreas, C. Dion, V. D. Sandberg, Presented by S. Biller, X. Q. Lu, R. W. Ellsworth, P. R. Vishwanath, T. J. Haines, and S. D. Biller
- Subjects
Physics ,Stars ,Muon ,Astronomy ,Cosmic ray ,Cosmic muons ,Astrophysics ,Anomalous behavior ,Time structure ,Lepton - Abstract
The 11 ‘‘in‐phase’’ source events from the 1986 muon‐rich bursts associated with Hercules X‐1 (previously reported by this group) have been studied for indications of further anomalous behavior. The most significant effect observed resulted from an analysis of the showerfront time‐structures of these events. This analysis was then applied a priori to the rest of the source day, where an additional ∼9 signal events are expected to remain. The same effect was observed at a chance probability level of ∼0.1%.
- Published
- 1991
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- View/download PDF
35. UHE point source survey at Cygnus experiment
- Author
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G. M. Dion, R. C. Allen, W. P. Zhang, D. Berley, P. R. Vishwanath, R. L. Talaga, J. Lloyd-Evans, Mike Stark, B. L. Dingus, X. Q. Lu, R. L. Burman, T. J. Haines, S. D. Biller, P. W. Kwok, G. B. Yodh, M. E. Potter, J. A. Goodman, R. Cady, D. E. Alexandreas, M. K. Gilra, V. D. Sandberg, D. E. Nagle, R. W. Ellsworth, C. M. Hoffman, and C. Y. Chang
- Subjects
Physics ,Crab Nebula ,Pulsar ,Sky ,Point source ,media_common.quotation_subject ,Binary star ,Astronomy ,Cosmic ray ,Astrophysics ,Right ascension ,Declination ,media_common - Abstract
A new method of searching for UHE point source has been developed. With a data sample of 150 million events, we have surveyed the sky for point sources over 3314 locations (1.4°
- Published
- 1991
- Full Text
- View/download PDF
36. JASA: A prototype water-Čerenkov air-shower detector
- Author
-
P. W. Kwok, C. M. Hoffman, R. S. Delay, D. Berley, E. Horch, C. Dion, X. Q. Lu, H. Ferguson, Mike Stark, R. Svoboda, R. W. Ellsworth, G. B. Yodh, J. A. Goodman, and T. J. Haines
- Subjects
Physics ,Pilot experiment ,Optics ,Air shower ,business.industry ,Detector ,Measuring instrument ,Astronomy ,Cosmic ray ,business ,Gamma detection ,Particle detector - Abstract
A small pilot experiment to examine the use of the water‐Cerenkov technique for air shower detection was installed near the center of the CYGNUS air shower array. Preliminary results showing general agreement with simulations are presented. Thus, the technique promises to offer significant advances for VHE‐UHE γ‐ray astronomy.
- Published
- 1991
- Full Text
- View/download PDF
37. A search for UHE cosmic ray from the Crab pulsar/nebula
- Author
-
D. A. Krakauer, P. W. Kwok, J. Lloyd-Evans, V. D. Sandberg, C. Y. Chang, Mike Stark, B. L. Dingus, D. Berley, G. M. Dion, P.R. Vishwanath, D. R. Cady, Presented by G. Dion, X. Q. Lu, D. E. Alexandreas, E. W. Ellsworth, M. E. Potter, R. L. Burman, T. J. Haines, S. D. Biller, G. B. Yodh, D. A. Nagle, J. A. Goodman, C. Dion, C. M. Hoffman, and W. P. Zhang
- Subjects
Physics ,Nebula ,Crab Nebula ,Air shower ,Pulsar ,Crab Pulsar ,Astronomy ,Flux ,Cosmic ray ,Astrophysics ,Gamma-ray burst - Abstract
A preliminary search is made for continuously pulsed, and burst, emission from the Crab pulsar or its nebula at ultra‐high energies using the CYGNUS air shower experiment. No evidence is found for pulsed emission over the entire data set of 1,075 days searched. A 90% confidence upper limit for the flux of cosmic rays at the interpulse phase is 6.9×10−14 cm−2s−1 above 50 TeV. A single day (JD=2447644.5,UTC=66700s to JD=2447645.5,UTC=11200s), is found to have a 4.1 σ excess corresponding to a chance probability of 2.2%; no evidence of the pulsar period is found on this day.
- Published
- 1991
- Full Text
- View/download PDF
38. Search for UHE emission from 4U0115+63
- Author
-
D. E. Nagle, D. Berley, D. A. Krakauer, P. W. Kwok, P. R. Vishwanath, J. A. Goodman, B. L. Dingus, R. C. Allen, D. R. Cady, W. P. Zhang, J. Lloyd-Evans, D. Dion, X. Q. Lu, G. M. Dion, S. Gupta, R. L. Burman, R. L. Talaga, D. E. Alexandreas, C. M. Hoffman, T. J. Haines, S. D. Biller, V. D. Sandberg, G. B. Yodh, C. Y. Chang, R. W. Ellsworth, M. E. Potter, Presented by D. E. Alexandreas, and Mike Stark
- Subjects
Physics ,Neutron star ,Air shower ,Pulsar ,Binary star ,X-ray binary ,Astronomy ,Flux ,Cosmic ray ,Astrophysics ,Orbital period - Abstract
We report here the preliminary results of our observations of the sporadic X‐binary system 4U0115+63. The CYGNUS air shower array has been collecting data since April 1986. No significant excess is seen from the direction of this source, nor any correlation with its 24‐day orbital period. A 90% confidence‐level upper limit on the flux from 4U0115+63 is 2.8×10−13 cm−2 s−1 above 50 TeV. This flux limit is considerably lower than those reported by other UHE experiments. Search for periodicity at the neutron star frequency is in progress.
- Published
- 1991
- Full Text
- View/download PDF
39. Recent data from the CYGNUS experiment
- Author
-
J. A. Goodman, R. Cady, J. Lloyd-Evans, D. E. Nagle, R. L. Burman, D. Berley, P. R. Vishwanath, B. L. Dingus, G. B. Yodh, Mike Stark, R. C. Allen, R. L. Talaga, D. E. Alexandreas, G. M. Dion, T. J. Haines, S. D. Biller, X. Q. Lu, C. M. Hoffman, V. D. Sandberg, W. P. Zhang, C. Y. Chang, R. W. Ellsworth, M. E. Potter, D. A. Krakauer, and P. W. Kwok
- Subjects
Physics ,Astrophysics::High Energy Astrophysical Phenomena ,Milky Way ,Astronomy ,Astrophysics ,Galaxy ,Radiation flux ,Air shower ,Crab Nebula ,Pulsar ,Physics::Accelerator Physics ,Angular resolution ,Gamma-ray burst ,Astrophysics::Galaxy Astrophysics - Abstract
Data from the CYGNUS extensive air shower experiment at Los Alamos, NM has been analyzed to study the angular resolution of the array, and to search for point sources in the galaxy. Results on searches for steady emission from Cyg X‐3, Her X‐1 and the Crab nebula are presented.
- Published
- 1991
- Full Text
- View/download PDF
40. Study of Cygnus X-3 at ultrahigh energies during the 1989 radio outbursts
- Author
-
M. E. Potter, R. L. Talaga, R. L. Burman, S. D. Biller, X. Q. Lu, R. Cady, J. A. Goodman, P. R. Vishwanath, C. M. Hoffman, V. D. Sandberg, Mike Stark, J. Lloyd-Evans, G. M. Dion, R. W. Ellsworth, W. Zhang, C. Y. Chang, G. B. Yodh, R. C. Allen, D. E. Nagle, Brenda Dingus, D. Berley, D. E. Alexandreas, and Todd Haines
- Subjects
Physics ,Muon ,X-ray binary ,General Physics and Astronomy ,Flux ,Astronomy ,Statistical analysis ,Cosmic ray ,Astrophysics ,Gamma-ray burst ,Radio astronomy - Abstract
A unique feature of Cygnus X-3 is that occasionally it has large radio outbursts that begin very abruptly and last for several days. Several experiments in the past have claimed to observe signals above 1 TeV correlated with these radio bursts; the most recent bursts occurred in June and July 1989. No significant signal was observed by the CYGNUS experiment over time scales longer than a day during this time; a 90%-confidence-level limit of 3.0{times}10{sup {minus}13} cm{sup {minus}2} s{sup {minus}1} is placed on the flux above 50 TeV during the period from 15 May to 31 July 1989.
- Published
- 1990
41. On designing parametrized systems using Ada
- Author
-
Mike Stark
- Subjects
Computer science ,Programming language ,computer.software_genre ,computer - Published
- 1990
- Full Text
- View/download PDF
42. Search for ultra-high energy radiation from gamma-ray bursts
- Author
-
D. D. Weeks, R. Schnee, G. E. Allen, G. B. Yodh, Luke Zoltan Kelley, T. Yang, J. A. Goodman, G. M. Dion, D. E. Alexandreas, M. Harmon, P. Chumney, C. Sinnis, M. Cavalli-Sforza, C. M. Hoffman, A. L. Shoup, D. E. Dorfan, M. L. Chen, C. Y. Chang, S. C. Schaller, J. P. Wu, Mike Stark, T. J. Haines, S. D. Biller, C. Dion, David A. Williams, D. E. Nagle, D. Berley, R. L. Burman, D. M. Schmidt, R. W. Ellsworth, D. G. Coyne, S. R. Klein, and W. P. Zhang
- Subjects
Physics ,Photon ,Space and Planetary Science ,Astronomy ,Astronomy and Astrophysics ,Gamma-ray astronomy ,Astrophysics ,Gamma-ray burst ,Astronomical spectroscopy ,Radiofrequency radiation - Published
- 1994
- Full Text
- View/download PDF
43. Search for Ultra--High-Energy Point-Source Emission over Various Timescales
- Author
-
M. L. Chen, G. E. Allen, David R. Williams, S. R. Klein, W. P. Zhang, D. C. Coyne, R. Schnee, P. Chumney, C. Dion, S. C. Schaller, Mike Stark, G. M. Dion, J. P. Wu, C. Y. Chang, D. M. Schmidt, D. E. Alexandreas, M. Cavalli-Sforza, A. L. Shoup, C. M. Hoffman, Luke Zoltan Kelley, T. Yang, R. L. Burman, J. A. Goodman, G. B. Yodh, T. J. Haines, D. E. Nagle, S. D. Biller, M. Harmon, R. W. Ellsworth, C. Sinnis, D. D. Weeks, D. E. Dorfan, and D. Berley
- Subjects
Physics ,High energy ,Space and Planetary Science ,Point source ,Astronomy ,Astronomy and Astrophysics ,Astrophysics - Published
- 1994
- Full Text
- View/download PDF
44. Search for Emission of Ultra--High-Energy Radiation from Active Galactic Nuclei
- Author
-
A. L. Shoup, D. E. Dorfan, D. E. Nagle, C. M. Hoffman, Luke Zoltan Kelley, T. Yang, P. Chumney, S. R. Klein, W. P. Zhang, D. D. Weeks, R. W. Ellsworth, R. L. Burman, G. M. Dion, M. Cavalli-Sforza, T. J. Haines, S. D. Biller, Mike Stark, David A. Williams, S. C. Schaller, C. Sinnis, D. Berley, D. E. Alexandreas, G. E. Allen, J. P. Wu, J. A. Goodman, G. B. Yodh, C. Y. Chang, M. L. Chen, D. C. Coyne, R. Schnee, and C. Dion
- Subjects
Physics ,Active galactic nucleus ,biology ,Flux ,Astronomy ,Astronomy and Astrophysics ,Astrophysics ,Radiation ,biology.organism_classification ,Space and Planetary Science ,Egret ,BL Lac object ,Radiofrequency radiation ,Continuous emission - Abstract
The CYGNUS air-shower array has been used to search for emission of ultra-high-energy gamma radiation from 13 active galactic nuclei (AGNs) that were detected by EGRET. The data set spans the period 1986 April 2 to 1993 January 1. The data set has been searched for continuous emission, for emission on the time scale of 1 week, and for emission on the time scale of 1 day. No evidence for emission from any of the AGNs on any of the time scales examined was found. The 90% Confidence Level (CL) upper limit to the continuous flux from Mrk 421 above 50 TeV is 7.5×10 -14 cm -1 s -1
- Published
- 1993
- Full Text
- View/download PDF
45. A synonymous germline variant in a gene encoding a cell adhesion molecule is associated with cutaneous mast cell tumour development in Labrador and Golden Retrievers.
- Author
-
Deborah Biasoli, Lara Compston-Garnett, Sally L Ricketts, Zeynep Birand, Celine Courtay-Cahen, Elena Fineberg, Maja Arendt, Kim Boerkamp, Malin Melin, Michele Koltookian, Sue Murphy, Gerard Rutteman, Kerstin Lindblad-Toh, and Mike Starkey
- Subjects
Genetics ,QH426-470 - Abstract
Mast cell tumours are the most common type of skin cancer in dogs, representing a significant concern in canine health. The molecular pathogenesis is largely unknown, but breed-predisposition for mast cell tumour development suggests the involvement of inherited genetic risk factors in some breeds. In this study, we aimed to identify germline risk factors associated with the development of mast cell tumours in Labrador Retrievers, a breed with an elevated risk of mast cell tumour development. Using a methodological approach that combined a genome-wide association study, targeted next generation sequencing, and TaqMan genotyping, we identified a synonymous variant in the DSCAM gene on canine chromosome 31 that is associated with mast cell tumours in Labrador Retrievers. DSCAM encodes a cell-adhesion molecule. We showed that the variant has no effect on the DSCAM mRNA level but is associated with a significant reduction in the level of the DSCAM protein, suggesting that the variant affects the dynamics of DSCAM mRNA translation. Furthermore, we showed that the variant is also associated with mast cell tumours in Golden Retrievers, a breed that is closely related to Labrador Retrievers and that also has a predilection for mast cell tumour development. The variant is common in both Labradors and Golden Retrievers and consequently is likely to be a significant genetic contributor to the increased susceptibility of both breeds to develop mast cell tumours. The results presented here not only represent an important contribution to the understanding of mast cell tumour development in dogs, as they highlight the role of cell adhesion in mast cell tumour tumourigenesis, but they also emphasise the potential importance of the effects of synonymous variants in complex diseases such as cancer.
- Published
- 2019
- Full Text
- View/download PDF
46. A search of the northern sky for ultra-high-energy point sources
- Author
-
P. R. Vishwanath, S. D. Biller, V. D. Sandberg, D. E. Alexandreas, R. W. Ellsworth, Todd Haines, C. Dion, C. M. Hoffman, R. L. Burman, D. A. Krakauer, P. W. Kwok, D. E. Nagle, C. Y. Chang, G. M. Dion, D. Berley, D. R. Cady, M. E. Potter, Brenda Dingus, B. K. Fujikawa, Mike Stark, S. J. Freedman, W. P. Zhang, J. A. Goodman, X. Q. Lu, G. B. Yodh, and C. Sinnis
- Subjects
Physics ,Point source ,media_common.quotation_subject ,Gamma ray ,Flux ,Astronomy and Astrophysics ,Cosmic ray ,Astrophysics ,Radiation ,Declination ,Air shower ,Space and Planetary Science ,Sky ,media_common - Abstract
A search has been made for steady emission or ultra-high-energy radiation from individual point sources over most or the northern sky. Over 2×10 8 air showers induced by primary particles or energy greater than about 10 TeV were recorded from 1986 April until 1991 May by the CYGNUS air shower array. No statistically significant excess above the background from the isotropic flux or cosmic rays was found for any direction in the sky from 0° to 80° declination. In addition, 49 specific potential sources were examined, and none showed a statistically significant excess or events
- Published
- 1991
- Full Text
- View/download PDF
47. Building an all-hazards agricultural emergency response system to maintain business continuity and promote the sustainable supply of food and agricultural products
- Author
-
Marie Culhane, Carol Cardona, Timothy J. Goldsmith, Kaitlyn St. Charles, Greg Suskovic, Beth Thompson, and Mike Starkey
- Subjects
emergency response ,emergency preparedness ,agriculture ,food security ,Agriculture ,Food processing and manufacture ,TP368-456 - Abstract
The response to an agricultural emergency that threatens to destroy crops or animals requires a rapid, coordinated state-level response from the outset. An authority should be established at the local level to initiate and enforce food embargoes, quarantine livestock or poultry premises, depopulate affected or potentially affected animals, and provide indemnity, when appropriate, for those depopulated animals or destroyed products. Depending on the scale of the threat, industry needs, state resources, and response capacity, the authority for these activities currently resides with the state and is supported by federal agencies. However, an all-encompassing all-hazards agricultural emergency response system can be constructed through collaborations with agricultural industry, state responders, and federal agencies. The formed response should include development of permitting guidance for controlled harvest and movement of unaffected crops, animals, and animal products. The ultimate goal is to effectively manage the emergency yet maintain agricultural business continuity.
- Published
- 2018
- Full Text
- View/download PDF
48. Identification of molecular genetic contributants to canine cutaneous mast cell tumour metastasis by global gene expression analysis.
- Author
-
Kelly Bowlt Blacklock, Zeynep Birand, Deborah Biasoli, Elena Fineberg, Sue Murphy, Debs Flack, Joyce Bass, Stefano Di Palma, Laura Blackwood, Jenny McKay, Trevor Whitbread, Richard Fox, Tom Eve, Stuart Beaver, and Mike Starkey
- Subjects
Medicine ,Science - Abstract
Cutaneous mast cell tumours are one of the most common canine cancers. Approximately 25% of the tumours metastasise. Activating c-kit mutations are present in about 20% of tumours, but metastases occur in the absence of mutations. Tumour metastasis is associated with significantly diminished survival in spite of adjuvant chemotherapy. Available prognostic tests do not reliably predict whether a tumour will metastasise. In this study we compared the global expression profiles of 20 primary cutaneous mast cell tumours that metastasised with those of 20 primary tumours that did not metastasise. The objective was to identify genes associated with mast cell tumour metastatic progression that may represent targets for therapeutic intervention and biomarkers for prediction of tumour metastasis. Canine Gene 1.1 ST Arrays were employed for genome-wide expression analysis of formalin-fixed, paraffin-embedded biopsies of mast cell tumours borne by dogs that either died due to confirmed mast cell tumour metastasis, or were still alive more than 1000 days post-surgery. Decreased gene expression in the metastasising tumours appears to be associated with a loss of cell polarity, reduced cell-cell and cell-ECM adhesion, and increased cell deformability and motility. Dysregulated gene expression may also promote extracellular matrix and base membrane degradation, suppression of cell cycle arrest and apoptosis, and angiogenesis. Down-regulation of gene expression in the metastasising tumours may be achieved at least in part by small nucleolar RNA-derived RNA and microRNA-effected gene silencing. Employing cross-validation, a linear discriminant analysis-based classifier featuring 19 genes that displayed two-fold differences in expression between metastasising and non-metastasising tumours was estimated to classify metastasising and non-metastasising tumours with accuracies of 90-100% and 70-100%, respectively. The differential expression of 9 of the discriminator genes was confirmed by quantitative reverse transcription-PCR.
- Published
- 2018
- Full Text
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49. Toward a general object-oriented software development methodology
- Author
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Mike Stark and Ed Seidewitz
- Subjects
Computer science ,Programming language ,business.industry ,Software development ,computer.software_genre ,Software sizing ,Software construction ,Component-based software engineering ,General Earth and Planetary Sciences ,Software design ,Software system ,Computer-aided software engineering ,business ,Software engineering ,computer ,General Environmental Science ,Booch method - Abstract
An object is an abstract software model of a problem domain entity. Objects are packages of both data and operations of that data (Goldberg 83, Booch 83). The Ada (tm) package construct is representative of this general notion of an object. Object-oriented design is the technique of using objects as the basic unit of modularity in systems design. The Software Engineering Laboratory at the Goddard Space Flight Center is currently involved in a pilot program to develop a flight dynamics simulator in Ada (approximately 40,000 statements) using object-oriented methods. Several authors have applied object-oriented concepts to Ada (e.g., Booch 83, Cherry 85). It was found that these methodologies are limited. As a result a more general approach was synthesized with allows a designer to apply powerful object-oriented principles to a wide range of applications and at all stages of design. An overview is provided of this approach. Further, how object-oriented design fits into the overall software life-cycle is considered.
- Published
- 1987
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50. Genome-Wide Analysis Identifies Germ-Line Risk Factors Associated with Canine Mammary Tumours.
- Author
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Malin Melin, Patricio Rivera, Maja Arendt, Ingegerd Elvers, Eva Murén, Ulla Gustafson, Mike Starkey, Kaja Sverdrup Borge, Frode Lingaas, Jens Häggström, Sara Saellström, Henrik Rönnberg, and Kerstin Lindblad-Toh
- Subjects
Genetics ,QH426-470 - Abstract
Canine mammary tumours (CMT) are the most common neoplasia in unspayed female dogs. CMTs are suitable naturally occurring models for human breast cancer and share many characteristics, indicating that the genetic causes could also be shared. We have performed a genome-wide association study (GWAS) in English Springer Spaniel dogs and identified a genome-wide significant locus on chromosome 11 (praw = 5.6x10-7, pperm = 0.019). The most associated haplotype spans a 446 kb region overlapping the CDK5RAP2 gene. The CDK5RAP2 protein has a function in cell cycle regulation and could potentially have an impact on response to chemotherapy treatment. Two additional loci, both on chromosome 27, were nominally associated (praw = 1.97x10-5 and praw = 8.30x10-6). The three loci explain 28.1±10.0% of the phenotypic variation seen in the cohort, whereas the top ten associated regions account for 38.2±10.8% of the risk. Furthermore, the ten GWAS loci and regions with reduced genetic variability are significantly enriched for snoRNAs and tumour-associated antigen genes, suggesting a role for these genes in CMT development. We have identified several candidate genes associated with canine mammary tumours, including CDK5RAP2. Our findings enable further comparative studies to investigate the genes and pathways in human breast cancer patients.
- Published
- 2016
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